Read by QxMD icon Read


Junchun Wang, Jinjin Guo, Junjun Zhang, Wenjuan Zhang, Yuzhong Zhang
C-reactive protein (CRP) is a widely accepted biomarker of cardiovascular disease and inflammation. In this study, a RNA aptamer-based electrochemical sandwich type aptasensor for CRP detection was described using the functionalized silica microspheres as immunoprobes. Silica microspheres (Si MSs), which have good monodispersity and uniform shape, were firstly synthesized. The silica microspheres functionlized with gold nanoparticles (Au NPs) provided large surface area for immobilizing signal molecules (Zinc ions, Zn(2+)) and antibodies (Ab)...
April 13, 2017: Biosensors & Bioelectronics
Julia Keith, Fu-Qiang Gao, Raza Noor, Alex Kiss, Gayathiri Balasubramaniam, Kelvin Au, Ekaterina Rogaeva, Mario Masellis, Sandra E Black
White matter hyperintensities (WMH) are prevalent. Although arteriolar disease has been implicated in their pathogenesis, venous pathology warrants consideration. We investigated relationships of WMH with histologic venous, arteriolar and white matter abnormalities and correlated findings with premortem neuroimaging. Three regions of periventricular white matter were sampled from archived autopsy brains of 24 pathologically confirmed Alzheimer disease (AD) and 18 age-matched nonAD patients. Using trichrome staining, venous collagenosis (VC) of periventricular veins (<150 µm in diameter) was scored for severity of wall thickening and occlusion; percent stenosis by collagenosis of large caliber (>200 µm) veins (laVS) was measured...
April 1, 2017: Journal of Neuropathology and Experimental Neurology
Rhys Heffernan, Yuedong Yang, Kuldip Paliwal, Yaoqi Zhou
Motivation: The accuracy of predicting protein local and global structural properties such as secondary structure and solvent accessible surface area has been stagnant for many years because of the challenge of accounting for non-local interactions between amino acid residues that are close in three-dimensional structural space but far from each other in their sequence positions. All existing machine-learning techniques relied on a sliding window of 10-20 amino acid residues to capture some "short to intermediate" non-local interactions...
April 18, 2017: Bioinformatics
Shouting Zhang, Zhuoyue Zhang, Tiansheng Wang, Dongxu Zhang, Xuemei Li, Zhonghua Xue, Duoliang Shan, Xiaoquan Lu
Herein, we present a catalysis-based, label-free, and efficient strategy for a rapid, high-throughput, highly selective and ultrasensitive naked-eye colorimetric assay of Au(3+) in aqueous solutions, based on the gold amalgam-stimulated peroxidase mimetic activity.
April 21, 2017: Chemical Communications: Chem Comm
Naema Othman, Pierre Berini
We propose and investigate a Schottky contact detector where the contact metal is a nanoscale metal stripe waveguide supporting surface plasmons with strong localization along the Schottky contact. We consider Au for the metal stripe, p-doped silicon for the semiconductor, operation in the infrared (at λ<sub>0</sub>=1550  nm), and internal photoemission as the sub-bandgap detection mechanism. We find that the main surface plasmon mode of operation of the Au stripe exhibits diverging real and imaginary parts of n<sub>eff</sub> with decreasing stripe dimensions, commensurate with increasing confinement...
April 20, 2017: Applied Optics
In-Bok Baek, Sangwon Byun, Bong Kuk Lee, Jin-Hwa Ryu, Yarkyeon Kim, Yong Sun Yoon, Won Ik Jang, Seongjae Lee, Han Young Yu
Using doubly-clamped silicon (Si) microbeam resonators, we demonstrate sub-attogram per Hertz (ag/Hz) mass sensitivity, which is extremely high sensitivity achieved by micro-scale MEMS mass sensors. We also characterize unusual buckling phenomena of the resonators. The thin-film based resonator is composed of a Si microbeam surrounded by silicon nitride (SiN) anchors, which significantly improve performance by providing fixation on the microbeam and stabilizing oscillating motion. Here, we introduce two fabrication techniques to further improve the mass sensitivity...
April 21, 2017: Scientific Reports
Yintao Liu, Renxu Jia, Yucheng Wang, Ziyang Hu, Yuming Zhang, Tiqiang Pang, Yuejin Zhu, Suzhen Luan
The zero drift can severely deteriorate the stability of light-dark current ratio, detectivity and responsivity of the photodetectors. In this paper, the effects of [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) doped perovskite based photodetector device on the inhibition of zero drift under dark state are discusses. Two kinds of photodetectors (Au/CH3NH3PbIxCl3-x/Au and Au/CH3NH3PbIxCl3-x:PCBM/Au) are prepared, and the materials and photodetector devices are measured by scanning electron microscope, X-ray diffraction, photoluminescence, ultra-violet absorption spectra, current-voltage and current-time...
April 21, 2017: ACS Applied Materials & Interfaces
Chang Lu, Zhicheng Huang, Biwu Liu, Yibo Liu, Yibin Ying, Juewen Liu
Attaching DNA to nanomaterials is the basis for DNA-directed assembly, sensing, and drug delivery using such hybrid materials. Poly-cytosine (poly-C) DNA is a high affinity ligand for four types of commonly used nanomaterials, including nanocarbons (graphene oxide and single-walled carbon nanotubes), transition metal dichalcogenides (MoS2 and WS2 ), metal oxides (Fe3 O4 and ZnO), and metal nanoparticles (Au and Ag). Compared to other homo-DNA sequences, poly-C DNA has the highest affinity for the first three types of materials...
April 21, 2017: Angewandte Chemie
Günther Krämer, Florian Hausen, Roland Bennewitz
The confinement of liquids in nanometer-scale gaps can lead to changes in their viscous shear properties. For liquids of polar molecules, the charge state of the confining surfaces has a significant influence on the structure in the confined liquid. Here we report on the implementation of dynamic shear force microscopy in an electrochemical cell. Lateral oscillations of the tip of an atomic force microscope were magnetically activated at a frequency of about 50 kHz. The damping of the lateral tip oscillation was recorded as a function of the tip-sample distance and of the electrode potential at the surface of a Au(100) single crystal electrode...
April 21, 2017: Faraday Discussions
Xin Gao, Xiangxuan Liu, Zuoming Zhu, Ying Gao, Qingbo Wang, Fei Zhu, Zheng Xie
In this paper, we propose a nanostructure with Au nanoparticles (NPs), as electron sinks, located at the most outside layer of CdS sensitized TiO2 nanorod arrays (TiO2 NRAs/CdS/Au). By the introduction of Au NPs, TiO2 NRAs/CdS/Au performs higher visible light photocatalytic capacity in the degradation of unsymmetrical dimethylhydrazine wastewater than TiO2 NRAs/CdS. The optimal deposition time for Au NPs is 30 s. The visible light induced degradation ability of TiO2 NRAs/CdS/Au (30 s) is 1.4 times that of TiO2 NRAs/CdS...
April 20, 2017: Scientific Reports
Masashi Nakamura, Takahiro Banzai, Yuto Maehata, Osamu Endo, Hiroo Tajiri, Osami Sakata, Nagahiro Hoshi
Understanding the electrocrystallization mechanisms of metal cations is of importance for many industrial and scientific fields. We have determined the transitional structures during underpotential deposition (upd) of various metal cations on Au(111) electrode using time-resolved surface X-ray diffraction and step-scan IR spectroscopy. At the initial stage of upd, a characteristic intensity transient appears in the time-resolved crystal truncation rod depending on metal cations. Metal cations with relatively high coordination energies of hydration water are deposited in two steps: first, the hydrated metal cations approached the surface and are metastably located at the outer Helmholtz plane, then they are deposited via the destruction of the hydration shell...
April 20, 2017: Scientific Reports
Michaela Lang, David Berry, Katharina Passecker, Ildiko Mesteri, Sabin Bhuju, Florian Ebner, Vitaly Sedlyarov, Rayko Evstatiev, Kyle Dammann, Alexander Loy, Orest Kuzyk, Pavel Kovarik, Vineeta Khare, Martin Beibel, Guglielmo Roma, Nicole Meisner-Kober, Christoph Gasche
HuR is an RNA-binding protein implicated in immune homeostasis and various cancers, including colorectal cancer. HuR binding to AU-rich elements within the 3' untranslated region of mRNAs encoding oncogenes, growth factors, and various cytokines leads message stability and translation. In this study, we evaluated HuR as a small-molecule target for preventing colorectal cancer in high-risk groups such as those with familial adenomatosis polyposis (FAP) or inflammatory bowel disease (IBD). In human specimens, levels of cytoplasmic HuR were increased in colonic epithelial cells from patients with IBD, IBD-cancer, FAP-adenoma, and colorectal cancer, but not in patients with IBD-dysplasia...
February 20, 2017: Cancer Research
Xing Huang, Jing Xu, Lin Chen, Yu Wang, Xiaobin Gu, Xuerong Peng, Guangyou Yang
BACKGROUND: Codon usage bias (CUB) is an important evolutionary feature in genomes that has been widely observed in many organisms. However, the synonymous codon usage pattern in the genome of T. multiceps remains to be clarified. In this study, we analyzed the codon usage of T. multiceps based on the transcriptome data to reveal the constraint factors and to gain an improved understanding of the mechanisms that shape synonymous CUB. RESULTS: Analysis of a total of 8,620 annotated mRNA sequences from T...
April 20, 2017: BMC Genomics
Martin Schade, Steffen Franzka, Nils Hartmann
Laser microprocessing of highly oriented pyrolytic graphite (HOPG) in conjunction with chemical functionalization routines are used to fabricate functional micro-sized domains. Infrared and Auger electron spectroscopy, contact angle measurements and electron microscopy are used for characterization of laser-fabricated structures. HOPG samples are coated with alkylsiloxane monolayers. Laser-induced bromination of coated HOPG samples in gaseous bromine is carried out using a microfocused laser beam at a wavelength of 514 nm and 1/e2 laser spot diameter of about 3 µm...
April 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Andrea E Schlather, Alejandro Manjavacas, Adam Lauchner, Valeria Spolon Marangoni, Christopher J DeSantis, Peter Nordlander, Naomi J Halas
There is currently a worldwide need to develop efficient photocatalytic materials that can reduce the high energy cost of common industrial chemical processes. One possible solution focuses on metallic nanoparticles (NPs) that can act as efficient absorbers of light due to their surface plasmon resonance. Recent work indicates that small NPs, when photoexcited, may allow for efficient electron or hole transfer necessary for photocatalysis. Here we investigate the mechanisms behind hot hole carrier dynamics by studying the photo-driven oxidation of citrate ions on Au@SiO2@Au core-shell nanoparticles...
April 20, 2017: Journal of Physical Chemistry Letters
Vincenzo Amendola, Roberto Pilot, Marco Frasconi, Onofrio M Maragò, Maria Antonia Iatì
In the last two decades, plasmon resonance in gold nanoparticles (Au NPs) has been the subject of intense research efforts. Plasmon physics is intriguing and its precise modelling proved to be challenging. In fact, plasmons are highly responsive to a multitude of factors, either intrinsic to the Au NPs or from the environment, and recently the need emerged for the correction of standard electromagnetic approaches with quantum effects. Applications related to plasmon absorption and scattering in Au NPs are impressively numerous, ranging from sensing to photothermal effects to cell imaging...
May 24, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Sujay A Chopade, Jesus G Au, Ziang Li, Peter W Schmidt, Marc A Hillmyer, Timothy P Lodge
Mechanically robust polymer electrolyte membranes (PEMs) exhibiting high ionic conductivity at ambient temperature are a prerequisite for next-generation electrochemical devices. We utilized a polymerization-induced microphase separation (PIMS) strategy to prepare nanostructured materials comprising continuous conducting nanochannels intertwined with a mechanically and thermally robust cross-linked polymeric framework. Addition of succinonitrile (SN) rendered the poly(ethylene oxide)/lithium (Li) salt conducting domains completely amorphous, resulting in outstanding conductivities (∼0...
April 20, 2017: ACS Applied Materials & Interfaces
A Le Beulze, S Gomez-Graña, H Gehan, S Mornet, S Ravaine, M Correa-Duarte, L Guerrini, R A Alvarez-Puebla, E Duguet, E Pertreux, A Crut, P Maioli, F Vallée, N Del Fatti, O Ersen, M Treguer-Delapierre
Raspberry-like nano-objects made of large plasmonic satellites (>10 nm) covering a central dielectric particle have many potential applications as photonic materials, superlenses and (bio-) sensors, but their synthesis remains challenging. Herein, we show how to build stable and robust raspberry-like nano-systems with close-packed satellites, by combining monodisperse silica particles (80 or 100 nm diameter) and oppositely charged noble metal nanoparticles (Au or Ag) with well-defined sizes (10-50 nm). The spectral characteristics of their associated plasmonic resonances (wavelength, linewidth, extinction cross-section) and the electromagnetic coupling between satellites were observed using the spatial modulation spectroscopy technique and interpreted through a numerical model...
April 20, 2017: Nanoscale
Weixuan Zhang, Tong Wu, Rongyao Wang, Xiangdong Zhang
We report here the chiroptical amplification effect occurring in the hybrid systems consisting of chiral molecules and Si nanostructures. Under resonant excitation of circularly polarized light, the hybrid systems show strong CD induction signals at the optical frequency, which arise from both the electric and magnetic responses of the Si nanostructures. More interestingly, the induced CD signals from Si-based dielectric nanoantennas are always larger than that from Au-based plasmonic counterparts. The related physical origin was disclosed...
April 20, 2017: Nanoscale
Yu-Chen Karen Chen-Wiegart, Ross Harder, David C Dunand, Ian McNulty
We studied the evolution of dealloying-induced strain along the {111} in a Ag-Au nano-crystal in situ, during formation of nanoporous gold at the initial stage of dealloying using Bragg coherent X-ray diffractive imaging. The strain magnitude with maximum probability in the crystal doubled in 10 s of dealloying. Although formation of nano-pores just began at the surface, the greatest strain is located 60-80 nm deep within the crystal. Dealloying induced a compressive strain in this region, indicating volume shrinkage occurred during pore formation...
April 20, 2017: Nanoscale
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"