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https://www.readbyqxmd.com/read/28227440/graphene-neural-interfaces-for-artifact-free-optogenetics
#1
Hongming Lyu, Xin Liu, Nick Rogers, Vikash Gilja, Duygu Kuzum, Hongming Lyu, Xin Liu, Nick Rogers, Vikash Gilja, Duygu Kuzum, Nick Rogers, Vikash Gilja, Xin Liu, Duygu Kuzum, Hongming Lyu
Light-induced artifacts in metal-based microelectrodes significantly limit simultaneous use of electrophysiology with optogenetics or optical imaging. In this work, we systematically investigate light-induced artifacts in Au and transparent graphene electrodes fabricated in the same batch. We demonstrate that the Au electrodes show light artifacts resembling genuine local field potentials, while graphene electrodes are free of light-induced artifacts. With its other desirable properties including high mechanical strength, good conductivity, transparency, and biocompatibility, graphene electrodes show great promise for combining electrical and optical modalities in the same experiment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226902/investigation-on-the-hermeticity-of-an-implantable-package-with-32-feedthroughs-for-neural-prosthetic-applications
#2
Lorenzo Bisoni, Matthias Mueller, Paul Cvancara, Caterina Carboni, Roberto Puddu, Luigi Raffo, Massimo Barbaro, Thomas Stieglitz, Lorenzo Bisoni, Matthias Mueller, Paul Cvancara, Caterina Carboni, Roberto Puddu, Luigi Raffo, Massimo Barbaro, Thomas Stieglitz, Roberto Puddu, Luigi Raffo, Lorenzo Bisoni, Matthias Mueller, Paul Cvancara, Caterina Carboni, Massimo Barbaro, Thomas Stieglitz
This paper presents an implantable package aimed at hosting a bidirectional neural interface for neural prosthetic applications. The package has been conceived to minimize the invasivity for the patient, for this reason a cylindrical container with an outer diameter of 7 mm and a length of 21 mm has been designed. The package, realized in alumina (Al2O3), presents 32 hermetic feedthroughs located at the top and bottom base of the cylinder. The hermetic housing has been assembled using a low-temperature soldering method based on a previous platinum/gold (Pt/Au) metallization of the ceramic parts...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226517/phase-to-amplitude-coupling-as-a-potential-biomarker-for-creative-ideation-an-eeg-study
#3
Mina Marmpena, Stavros I Dimitriadis, Nitish Thakor, Anastasios Bezerianos, Mina Marmpena, Stavros I Dimitriadis, Nitish Thakor, Anastasios Bezerianos, Stavros I Dimitriadis, Mina Marmpena, Nitish Thakor, Anastasios Bezerianos
The most consistent finding of creative ideation in the neuroscientific study of creativity is the increment of EEG α power. However, the majority of existing studies focused only on ERP experimental paradigms while only a few analyzed time-related changes of EEG α power patterns during the time unlocked creation of ideas. Here, we designed an experimental paradigm where the participants were asked to generate alternative uses of everyday objects (AU task). For the control task, we adopted an Object Characteristics (OC) task, for which participants were asked to list typical characteristics or properties of an object...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225605/electrostatic-control-of-regioselectivity-in-au-i-catalyzed-hydroarylation
#4
Vivian M Lau, William C Pfalzgraff, Thomas E Markland, Matthew W Kanan
Competing pathways in catalytic reactions often involve transition states with very different charge distributions, but this difference is rarely exploited to control selectivity. The proximity of a counterion to a charged catalyst in an ion paired complex gives rise to strong electrostatic interactions that could be used to energetically differentiate transition states. Here we investigate the effects of ion pairing on the regioselectivity of the hydroarylation of 3-substituted phenyl propargyl ethers catalyzed by cationic Au(I) complexes, which forms a mixture of 5- and 7-substituted 2H-chromenes...
February 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28225258/nanoparticle-based-discrimination-of-single-nucleotide-polymorphism-in-long-dna-sequences
#5
Maria Sanroman-Iglesias, Charles Lawrie, Luis M Liz-Marzán, Marek Grzelczak
Circulating DNA (ctDNA) and specifically the detection cancer-associated mutations in liquid biopsies promises to revolutionize cancer detection. The main difficulty however is that the length of typical ctDNA fragments (~150 bases) can form secondary structures potentially obscuring the mutated fragment from detection. We show that an assay based on gold nanoparticles (65 nm) stabilized with DNA (Au@DNA) can discriminate single nucleotide polymorphism in clinically-relevant DNA sequences (70-140 bases). The preincubation step was crucial to this process, allowing sequential bridging of Au@DNA, so that single base mutation can be discriminated, down to 100 pM concentration...
February 22, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28225117/gold-nanoparticles-and-the-corresponding-filter-membrane-as-chemosensors-and-adsorbents-for-dual-signal-amplification-detection-and-fast-removal-of-mercury-ii
#6
Gaosong Chen, Jun Hai, Hao Wang, Weisheng Liu, Fengjuan Chen, Baodui Wang
Nowadays, the development of a multifunction system for the simultaneous multiple signal amplification detection and fast removal of Hg(2+) remains a major challenge. Herein, we for the first time used gold nanoparticles (Au NPs) and the corresponding filter membrane as chemosensors and adsorbents for dual signal amplification detection and fast removal of Hg(2+). Such a system was based on the formation of gold amalgam and a gold amalgam-based reaction between rhodamine B (RhB) and NaBH4 with fluorescence and colorimetric sensing functions...
February 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28225053/genetically-predicted-milk-consumption-and-bone-health-ischemic-heart-disease-and-type-2-diabetes-a-mendelian-randomization-study
#7
Q Yang, S L Lin, S L Au Yeung, M K Kwok, L Xu, G M Leung, C M Schooling
BACKGROUND/OBJECTIVES: Milk provides protein and micronutrients, and is recommended by some dietary guidelines, particularly for bone health. Meta-analysis of small randomized controlled trials suggests that milk may increase bone mineral density, but they are very heterogeneous. No randomized controlled trial has assessed the effects of milk on major chronic diseases. Previous Mendelian randomization studies of milk did not consider bone health, found no effects on ischemic heart disease (IHD) or type 2 diabetes (T2D) but higher body mass index...
February 22, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28224132/dataset-of-longitudinal-analysis-of-tear-cytokine-levels-cd4-cd8-counts-and-hiv-viral-load-in-dry-eye-patients-with-hiv-infection
#8
Praveen Kumar Balne, Rupesh Agrawal, Veonice Bijin Au, Bernett Lee, Eileen Loo, Louis Tong, Arkasubhra Ghosh, Stephen C Teoh, John Connolly, Petrina Tan
The data presented in this article shows the longitudinal analysis of tear fluid cytokine profiles, blood CD4 and CD8 counts and HIV viral load in 34 dry eye patients with HIV infection during the HAART therapy. Clinical samples were collected from HIV patients with dry eye disease at the time of presentation to the clinic (visit 1), three months (visit 2) and 6 months (visit 3) after the presentation. At each time point tear samples were evaluated for 41 cytokines using Luminex bead based multiplex assay and blood samples were tested for HIV viral load and CD4 and CD8 counts...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28223551/magnetic-tuning-of-upconversion-luminescence-in-au-nagdf-sub-4-sub-yb-sup-3-sup-er-sup-3-sup-nanocomposite
#9
Gangtao Dai, Zhiqiang Zhong, Xiaofeng Wu, Shiping Zhan, Shigang Hu, Pan Hu, Junshan Hu, Shaobing Wu, Junbo Han, Yunxin Liu
Lanthanide doped upconversion nanoparticles NaGdF4:Yb3+/Er3+ received increasing attention due to their unique optical-magnetic bifunctional properties. Here, we show that the luminescent intensity from NaGdF4:Yb3+/Er3+ nanoparticles decreases monotonously with increasing the applied magnetic field from 0 to 37.1 T, while Plasmon enhanced upconversion luminescence in Au/NaGdF4:Yb3+/Er3+ nanocomposite is independent from a magnetic field lower than 6 T. The surface plasmon resonances could compensate for the energetic mismatching between the excitation light and the energy level gaps induced by magnetic field and enhance the radiative efficiency that are main factors for achieving this stable upconversion emission in this nanocomposite under a magnetic field not higher than 6 T...
February 22, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28223472/overexpression-of-sarcoendoplasmic-reticulum-calcium-atpase-2a-promotes-cardiac-sympathetic-neurotransmission-via-abnormal-endoplasmic-reticulum-and-mitochondria-ca-2-regulation
#10
Julia Shanks, Neil Herring, Errin Johnson, Kun Liu, Dan Li, David J Paterson
Reduced cardiomyocyte excitation-contraction coupling and downregulation of the SERCA2a (sarcoendoplasmic reticulum calcium ATPase 2a) is associated with heart failure. This has led to viral transgene upregulation of SERCA2a in cardiomyocytes as a treatment. We hypothesized that SERCA2a gene therapy expressed under a similar promiscuous cytomegalovirus promoter could also affect the cardiac sympathetic neural axis and promote sympathoexcitation. Stellate neurons were isolated from 90 to 120 g male, Sprague-Dawley, Wistar Kyoto, and spontaneously hypertensive rats...
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28223153/evaluations-of-implementation-at-early-adopting-lung-cancer-screening-programs-lessons-learned
#11
Yaron B Gesthalter, Elisa Koppelman, Rendelle Bolton, Christopher G Slatore, Sue H Yoon, Hilary C Cain, Nichole T Tanner, David H Au, Jack A Clark, Renda Soylemez Wiener
BACKGROUND: Guidelines recommend lung cancer screening and it is currently being adopted nationwide. The American College of Chest Physicians advises inclusion of specific programmatic components to ensure high-quality screening. However, little is known about how lung cancer screening has been implemented in practice. We sought to evaluate the experience of early-adopting programs, characterize barriers faced, and identify strategies to achieve successful implementation. METHODS: We performed qualitative evaluations of lung cancer screening implementation at three Veterans Health Administration facilities, conducting semi-structured interviews with key staff (n=29)...
February 18, 2017: Chest
https://www.readbyqxmd.com/read/28222043/electrostatic-effects-of-au-nanoparticles-on-near-infrared-photoluminescence-from-si-sige-due-to-nanoscale-metal-semiconductor-contact
#12
Yefei Yin, Ze Wang, Shuguang Wang, Yujie Bai, Zuimin Jiang, Zhenyang Zhong
The photoluminescence from the Si and the SiGe is comprehensively modified by the Au NPs under the excitation without the surface plasmon resonance. Moreover, it sensitively depends on the size of the Au NPs, the excitation power and the thickness of Si between the Au NPs and the SiGe. A model is proposed in terms of the electrostatic effects of the naturally charged Au NPs due to the electron transferring through the nanoscale metal/semiconductor Schottky junction without an external bias and an external injection of carriers...
February 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28221811/deformation-localisation-in-molecular-layers-constrained-between-self-assembled-au-nanoparticles
#13
Guillaume Copie, Moussa Biaye, Heinrich Diesinger, Thierry Mélin, Christophe Krzeminski, Fabrizio Cleri
The localised deformation of molecular monolayers constrained between the spherical surfaces of Au nanoparticles is studied by means of molecular dynamics simulations. Alkyl or polyethylene glycol long-chain molecules were homogeneously distributed over the curved Au surface, pushed against each other by repeated cycles of force relaxation and constant-volume equilibration, at temperatures increasing from 50 to 300K, before being slowly quenched down to near-zero temperature. Plots of minimum configurational energy can be obtained as a function of the nanoparticle distance, according to different directions of approach; therefore, such simulations describe a range of deformations, from perfectly uniaxial compression, to a combination of compression and shear...
February 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28221757/cooperative-electron-phonon-coupling-and-buckled-structure-in-germanene-on-au-111
#14
Jincheng Zhuang, Nan Gao, Zhi Li, Xun Xu, Jiaou Wang, Jijun Zhao, Shi Xue Dou, Yi Du
Germanene, single-atom-thick germanium nanosheet in a honeycomb lattice, was proposed to be a Dirac-fermion material beyond graphene. We performed scanning tunneling microscopy and in-situ Raman spectroscopy studies combined with first-principles calculations on the atomic structures, and the electronic and phonon properties of germanene on Au(111). The low-buckled 1×1 germanene honeycomb lattice was determined to exist in an unexpected rectangular √7×√7 superstructure. Through in-situ Raman measurements, distinctive vibrational phonon modes were discovered in √7×√7 germanene, revealing the special coupling between Dirac fermion and lattice vibrations, namely, electron-phonon coupling (EPC)...
February 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28221733/regional-lung-ventilation-pattern-in-preschool-children-with-bronchopulmonary-dysplasia-is-modified-by-bronchodilator-response
#15
Wojciech Durlak, Małgorzata Klimek, Przemko Kwinta
BACKGROUND: Bronchopulmonary dysplasia (BPD) remains a significant long-term complication of prematurity. A standardized method of pulmonary function testing is still not available in preschool children with BPD. We investigated the feasibility of Electrical Impedance Segmentography (EIS) monitoring in this group and the impact of bronchodilator response (BDR) to salbutamol on the pattern of lung ventilation. METHODS: We conducted a follow-up study of 4-year-old premature children who had been treated in the tertiary NICU...
March 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28221715/hybrid-nanoparticle-pyramids-for-intracellular-dual-micrornas-biosensing-and-bioimaging
#16
Si Li, Liguang Xu, Maozhong Sun, Xiaoling Wu, Liqiang Liu, Hua Kuang, Chuanlai Xu
This study strategically fabricates multifunctional nanopyramids to allow the ultrasensitive quantification of dual microRNAs (miR-203(b) and miR-21) in living cells and their responsive bioimaging in vivo. The nanopyramids, composed of Au-Cu9 S5 nanoparticles (NPs), upconversion NPs (UCNPs), and Ag2 S NPs, emit two luminescent signals simultaneously with excitation at 808 nm, arising from the UCNPs at 541 nm in the visible region and from the Ag2 S NPs at 1227 nm in the second window of near-infrared (NIR-II) region...
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28220973/enzyme-controlled-nanodevice-for-acetylcholine-triggered-cargo-delivery-based-on-janus-au-mesoporous-silica-nanoparticles
#17
Antoni Llopis-Lorente, Paula Diez, Cristina de la Torre, Alfredo Sanchez, Felix Sancenon, Elena Aznar, Maria D Marcos, Paloma Martínez-Ruíz, Ramón Martínez-Máñez, Reynaldo Villalonga
This work reports a new gated nanodevice for acetylcholine-triggered cargo delivery. We prepared and characterized Janus Au-mesoporous silica nanoparticles functionalized with acetylcholinesterase on the Au face and with supramolecular β-cyclodextrin:benzimidazole inclusion complexes as caps on the mesoporous silica face. The nanodevice is able to selectively deliver the cargo in the presence of acetylcholine via enzyme-mediated acetylcholine hydrolysis, locally lowering the pH and opening the supramolecular gate...
February 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28220682/the-treadmill-of-production-and-the-positional-economy-of-consumption
#18
Dean Curran
The theory of the treadmill of production highlights how the constant search for economic growth leads to advanced economies being stuck on a "treadmill," where their well-being is not improved by economic growth, yet the impacts of this pursuit of growth causes massive, unsustainable environmental damages. In interrogating the specific driving force that keeps the irrational system of the treadmill so powerfully in place, the theory of the treadmill of production focuses on how those who control the production process, corporations, are the primary agents driving the treadmill, while also highlighting how the state and workers generally continue to provide support for the treadmill's continued reproduction...
February 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28220680/an-environmental-sociology-for-the-anthropocene
#19
Gary Bowden
Attention to the relationship between nature and society has been a defining feature of environmental sociology since its inception. Early research, incorporating insights from ecology, argued for the need to (1) theorize the causal connections between nature and society and (2) contextualize those connections in terms of biophysical limits resulting from resource scarcity. Over the past two decades, partly in response to new forms of existential threat such as climate change, the treatment of nature and society as distinct entities has given way to a focus on socio-natural assemblages...
February 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28220679/the-lac-m%C3%A3-gantic-derailment-corporate-regulation-and-neoliberal-sovereignty
#20
David Tyler Dunford
On July 6, 2013, Montreal, Maine, and Atlantic railcar 5017 hauling 72 tanker cars of Bakken crude oil derailed over the town of Lac-Mégantic, Quebec. The town erupted in a fiery inferno as 5,560,000 liters of highly flammable Bakken crude oil exploded over the town, killing 47 people and contaminating 558,000 tons of soil and local waterways. While Montreal, Maine, and Atlantic Rail Chairman Edward Burkhardt initially blamed the derailment on the lone engineer and local firefighters, this study shows how Transport Canada and the rail industry undermined regulatory and safety measures for several years before the derailment...
February 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
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