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https://www.readbyqxmd.com/read/28646228/coronal-mass-ejections-are-not-coherent-magnetohydrodynamic-structures
#1
M J Owens, M Lockwood, L A Barnard
Coronal mass ejections (CMEs) are episodic eruptions of solar plasma and magnetic flux that travel out through the solar system, driving extreme space weather. Interpretation of CME observations and their interaction with the solar wind typically assumes CMEs are coherent, almost solid-like objects. We show that supersonic radial propagation of CMEs away from the Sun results in geometric expansion of CME plasma parcels at a speed faster than the local wave speed. Thus information cannot propagate across the CME...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28646021/eif1ax-and-nras-mutations-co-occur-and-cooperate-in-low-grade-serous-ovarian-carcinomas
#2
Dariush Etemadmoghadam, Walid J Azar, Ying Lei, Tania Moujaber, Dale W Garsed, Catherine Kennedy, Sian Fereday, Chris Mitchell, Yoke-Eng Chiew, Joy Hendley, Australian Ovarian Cancer Study Group, Raghwa Sharma, Paul Harnett, Jason Li, Elizabeth L Christie, Ann-Marie Patch, Joshy George, George Au-Yeung, Gisela Mir Arnau, Timothy P Holloway, Timothy Semple, John V Pearson, Nicola Waddell, Sean Grimmond, Martin Köbel, Helen Rizos, Ivan Lomakin, David D L Bowtell, Anna DeFazio
Low-grade serous ovarian carcinomas (LGSC) are associated with a poor response to chemotherapy and are molecularly characterized by RAS pathway activation. Using exome and whole genome sequencing we identified recurrent mutations in the protein translational regulator EIF1AX and in NF1, USP9X, KRAS, BRAF and NRAS. RAS pathway mutations were mutually exclusive, however we found significant co-occurrence of mutations in NRAS and EIF1AX Missense EIF1AX mutations were clustered at the N-terminus of the protein in a region associated with its role in ensuring translational initiation fidelity...
June 23, 2017: Cancer Research
https://www.readbyqxmd.com/read/28645112/tap63%C3%AE-and-%C3%AE-np63%C3%AE-are-regulated-by-rbm38-via-mrna-stability-and-have-an-opposing-function-in-growth-suppression
#3
Wensheng Yan, Yanhong Zhang, Xinbin Chen
The p63 gene is expressed as TAp63 from the P1 promoter and as ΔNp63 from the P2 promoter. Through alternative splicing, five TA and five ΔN isoforms (α-ε) are expressed. Isoforms α-β and δ share an identical 3' untranslated region (3'UTR) whereas isoform γ has a unique 3'UTR. Recently, we found that RBM38 RNA-binding protein is a target of p63 and RBM38 in turn regulates p63α/β expression via mRNA stability. However, it is uncertain whether p63γ has a unique biological activity and whether p63γ is regulated by RBM38...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28644818/fabrication-and-optical-properties-of-nanostructured-plasmonic-al2o3-au-al2o3-al2o3-metamaterials
#4
Hicham Bakkali, Eduardo Blanco, Manuel Dominguez, Jose S Garitaonandia
Discontinuous multilayer (DML) thin films, which consist of nano-granular metals (NGMs) embedded in a dielectric matrix, have attracted significant interest as engineered plasmonic metamaterials. In this study, a systematic layer-by-layer deposition of three-dimensional sub-wavelength periodic plasmonic DML structures via the radio frequency sputtering of a composite target has been reported. The overall optical response of the DML films composed of AuAl2O3 NGM homogenous layers, which are periodically sandwiched between two amorphous Al2O3 layers, are studied using reflection spectroscopic ellipsometry and transmission spectroscopy techniques...
June 23, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28644668/strong-light-matter-interactions-in-single-open-plasmonic-nanocavities-at-the-quantum-optics-limit
#5
Renming Liu, Zhang-Kai Zhou, Yi-Cong Yu, Tengwei Zhang, Hao Wang, Guanghui Liu, Yuming Wei, Huanjun Chen, Xue-Hua Wang
Reaching the quantum optics limit of strong light-matter interactions between a single exciton and a plasmon mode is highly desirable, because it opens up possibilities to explore room-temperature quantum devices operating at the single-photon level. However, two challenges severely hinder the realization of this limit: the integration of single-exciton emitters with plasmonic nanostructures and making the coupling strength at the single-exciton level overcome the large damping of the plasmon mode. Here, we demonstrate that these two hindrances can be overcome by attaching individual J aggregates to single cuboid Au@Ag nanorods...
June 9, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28644612/suppressing-isomerization-of-phosphine-protected-au9-cluster-by-bond-stiffening-induced-by-a-single-pd-atom-substitution
#6
Seiji Yamazoe, Shota Matsuo, Satoru Muramatsu, Shinjiro Takano, Kiyofumi Nitta, Tatsuya Tsukuda
The fluxional nature of small gold clusters has been exemplified by reversible isomerization between [Au9(PPh3)8](3+) with a crown motif (Au9(C)) and that with a butterfly motif (Au9(B)) induced by association and dissociation with compact counteranions (NO3(-), Cl(-)). However, structural isomerization was suppressed by substitution of the central Au atom of the Au9 core in [Au9(PPh3)8](3+) with a Pd atom: [PdAu8(PPh3)8](2+) with a crown motif (PdAu8(C)) did not isomerize to that with a butterfly motif (PdAu8(B)) upon association with the counteranions...
June 23, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28644502/au3-%C3%AE-3-s-0e-elementary-block-new-insights-into-ligated-gold-clusters-with-%C3%AE-3-sulfido-motifs
#7
Wen Wu Xu, Xiao Cheng Zeng, Yi Gao
An understanding of the structural stability and formation mechanism of ligated gold nanoclusters with triply coordinated μ3-sulfido (μ3-S) motifs is important not only for gold chemistry but also for the design of more effective catalysts or drug carriers for various applications. In this article, a new elementary block Au3(μ3-S) with zero valence electrons [referred to as Au3(μ3-S)(0e)] has been identified, which describes all crystallized ligated gold clusters with μ3-S motifs, in conjunction with the previously reported Au3(2e) and Au4(2e) elementary blocks, in a grand unified model (GUM)...
June 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28644380/adenosine-triphosphate-encapsulated-liposomes-with-plasmonic-nanoparticles-for-surface-enhanced-raman-scattering-based-immunoassays
#8
Xuan-Hung Pham, Eunil Hahm, Tae Han Kim, Hyung-Mo Kim, Sang Hun Lee, Yoon-Sik Lee, Dae Hong Jeong, Bong-Hyun Jun
In this study, we prepared adenosine triphosphate (ATP) encapsulated liposomes, and assessed their applicability for the surface enhanced Raman scattering (SERS)-based assays with gold-silver alloy (Au@Ag)-assembled silica nanoparticles (NPs; SiO₂@Au@Ag). The liposomes were prepared by the thin film hydration method from a mixture of l-α-phosphatidylcholine, cholesterol, and PE-PEG2000 in chloroform; evaporating the solvent, followed by hydration of the resulting thin film with ATP in phosphate-buffered saline (PBS)...
June 23, 2017: Sensors
https://www.readbyqxmd.com/read/28644355/outpatient-liver-biopsy-in-children-safety-feasibility-and-economic-impact
#9
Rishi Bolia, Judy Matta, Rohan Malik, Winita Hardikar
Liver biopsy is a valuable tool. Even though outpatient liver biopsies are routinely performed in adults, there are no clear recommendations on its safety and feasibility in children. We reviewed the records of children who underwent a percutaneous liver biopsy at our institution between January 2005 and June 2015. A total of 626 biopsies were performed on 497 patients (250 boys, median age 6 [0.2-19.3] years). Abnormal liver function tests for investigation 288 (46%) was the most common indication. Thirty (4...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28644152/incorporating-hypr-de-noising-within-iterative-pet-reconstruction-hypr-osem
#10
Ju-Chieh Kevin Cheng, Julian C Matthews, Vesna Sossi, Jose Anton-Rodriguez, Andre Salomon, Ronald Boellaard
HighlY constrained back-PRojection (HYPR) is a post-processing de-noising technique originally developed for time-resolved Magnetic Resonance Imaging. It has been recently applied to dynamic imaging for Positron Emission Tomography (PET) and shown promising results. In this work, we have developed an iterative reconstruction algorithm (HYPR-OSEM) which improves the signal-to-noise ratio (SNR) in static imaging (i.e. single frame reconstruction) by incorporating HYPR de-noising directly within the ordered subsets expectation maximization (OSEM) algorithm...
June 23, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28644016/color-tunable-and-white-light-luminescence-in-lanthanide-dicyanoaurate-coordination-polymers
#11
Ryan J Roberts, Debbie Le, Daniel B Leznoff
The new lanthanide-dicyanoaurate coordination polymers [(n)Bu4N]2[Ln(NO3)4Au(CN)2] (Ln = Sm, Dy) and Sm[Au(CN)2]3·3H2O were prepared and structurally characterized and their luminescence spectra described. The emissions of solid-solutions of [(n)Bu4N]2[Ln(NO3)4Au(CN)2] (Ln = Ce, Sm, Eu, Tb, and Dy) were explored with an emphasis on their capacity for luminescent color tuning and white-light emission via the selection of composition, excitation wavelength, and temperature. Specifically, the binary solid-solutions [(n)Bu4N]2[Ce0...
June 23, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28644005/from-electrochemistry-to-electroluminescence-development-and-application-in-ratiometric-aptasensor-for-aflatoxin-b1
#12
Long Wu, Fan Ding, Wenmin Yin, Jing Ma, Biru Wang, Axiu Nie, Heyou Han
Aflatoxin B1 (AFB1), one of the most toxic chemical carcinogens, has been widely studied. It remains challenging to develop simple, accurate and sensitive analytical methods for the detection of AFB1 in food matrices. In this work, based on dual-signaling strategy, a ratiometric aptasensor was designed and verified for the accurate and sensitive detection of AFB1. The electrochemical method was first used as a model to verify the specific interaction between AFB1 and the aptamer, in which ferrocene (Fc) and methylene blue (MB) anchored DNA sequences were acted as dual signals...
June 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28643795/the-genomic-landscape-of-tuberous-sclerosis-complex
#13
Katie R Martin, Wanding Zhou, Megan J Bowman, Juliann Shih, Kit Sing Au, Kristin E Dittenhafer-Reed, Kellie A Sisson, Julie Koeman, Daniel J Weisenberger, Sandra L Cottingham, Steven T DeRoos, Orrin Devinsky, Mary E Winn, Andrew D Cherniack, Hui Shen, Hope Northrup, Darcy A Krueger, Jeffrey P MacKeigan
Tuberous sclerosis complex (TSC) is a rare genetic disease causing multisystem growth of benign tumours and other hamartomatous lesions, which leads to diverse and debilitating clinical symptoms. Patients are born with TSC1 or TSC2 mutations, and somatic inactivation of wild-type alleles drives MTOR activation; however, second hits to TSC1/TSC2 are not always observed. Here, we present the genomic landscape of TSC hamartomas. We determine that TSC lesions contain a low somatic mutational burden relative to carcinomas, a subset feature large-scale chromosomal aberrations, and highly conserved molecular signatures for each type exist...
June 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28643724/successful-surgical-management-of-bilateral-epiretinal-membrane-in-a-child-with-only-caf%C3%A3-au-lait-spots
#14
Swetha Sara Philip, Thomas Kuriakose, Geeta Chacko
A 6-year-old boy diagnosed as anisometropic amblyopia, with only café-au-lait spots and a family history of neurofibromatosis, presented with decrease in vision in the both eyes. Dilated fundus examination showed epiretinal membrane in both eyes over the macula. He underwent successful surgical management of the epiretinal membrane.
June 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28643433/electrochemical-ters-elucidates-potential-induced-molecular-reorientation-of-adenine-au-111
#15
Natalia Martín Sabanés, Tatsuhiko Ohto, Denis Andrienko, Yuki Nagata, Katrin F Domke
Electrochemical surface activity arises from the interaction and geometric arrangement of molecules at electrified interfaces. We present a novel electrochemical tip-enhanced Raman spectroscope that can access the vibrational fingerprint of less than 100 small, non-resonant molecules adsorbed at atomically flat Au electrodes to study their adsorption geometry and chemical reactivity as a function of applied potential. Combining experimental and simulation data for showcase adenine/Au(111), we conclude that protonated physisorbed adenine adapts a tilted orientation at low potentials while it is vertically adsorbed around the potential of zero charge...
June 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28643414/associating-and-dissociating-nanodimer-analysis-for-quantifying-ultra-small-amounts-of-dna
#16
Keunsuk Kim, Jeong-Wook Oh, Young Kwang Lee, Jiwoong Son, Jwa-Min Nam
Amplification- and enzyme-free quantification of DNA at ultra-low concentrations, on the orders of 10-1,000 targets, is highly beneficial, but is extremely challenging. To address this challenge, true detection signals should be reliably discriminated from false or noise signals. Here, we developed the dynamically associating and dissociating nanodimer analysis (ADNA) method that allows for collecting maximum detection signals from true target-binding events while keeping nonspecific signals at minimum level...
June 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28643041/skull-fracture-with-effacement-of-the-superior-sagittal-sinus-following-drone-impact-a-case-report
#17
Lawrance K Chung, Yuri Cheung, Carlito Lagman, Nicholas Au Yong, Duncan Q McBride, Isaac Yang
BACKGROUND: The popularity of unmanned aerial vehicles, or drones, raises safety concerns as they become increasingly common for commercial, personal, and recreational use. Collisions between drones and people may result in serious injuries. CASE REPORT: A 13-year-old male presented with a comminuted depressed skull fracture causing effacement of the superior sagittal sinus secondary to a racing drone impact. The patient experienced a brief loss of consciousness and reported lower extremity numbness and weakness after the accident...
June 22, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28642435/a-catalytic-fluoride-rebound-mechanism-for-c-sp-3-cf3-bond-formation
#18
Mark D Levin, Tiffany Q Chen, Megan E Neubig, Cynthia M Hong, Cyril A Theulier, Ilia J Kobylianskii, Mustafa Janabi, James P O'Neil, F Dean Toste
The biological properties of trifluoromethyl compounds have led to their ubiquity in pharmaceuticals, yet their chemical properties have made their preparation a substantial challenge, necessitating innovative chemical solutions. We report the serendipitous discovery of a borane-catalyzed formal C(sp(3))-CF3 reductive elimination from Au(III) that accesses these compounds by a distinct mechanism proceeding via fluoride abstraction, migratory insertion, and C-F reductive elimination to achieve a net C-C bond construction...
June 23, 2017: Science
https://www.readbyqxmd.com/read/28642235/atomic-layered-au-clusters-on-%C3%AE-moc-as-catalysts-for-the-low-temperature-water-gas-shift-reaction
#19
Siyu Yao, Xiao Zhang, Wu Zhou, Rui Gao, Wenqian Xu, Yifan Ye, Lili Lin, Xiaodong Wen, Ping Liu, Bingbing Chen, Ethan Crumlin, Jinghua Guo, Zhijun Zuo, Weizhen Li, Jinglin Xie, Li Lu, Christopher J Kiely, Lin Gu, Chuan Shi, José A Rodriguez, Ding Ma
The water-gas shift (WGS) reaction (CO+H2O=H2+CO2) is an essential process for hydrogen generation and CO removal in various energy-related chemical operations. This equilibrium-limited reaction is favored at a low working temperature. Potential application in fuel cells also requires a WGS catalyst to be highly active, stable and energy-efficient and match the working temperature of on-site hydrogen generation and consumption units. We synthesized Au layered clusters on an α-MoC substrate to create an interfacial catalyst system for the ultra-low-temperature WGS reaction...
June 22, 2017: Science
https://www.readbyqxmd.com/read/28640995/colloidal-gold-nanoparticles-induce-changes-in-cellular-and-subcellular-morphology
#20
Xiaowei Ma, Raimo Hartmann, Dorleta Jimenez de Aberasturi, Fang Yang, Stefaan J H Soenen, Bella B Manshian, Jonas Franz, Daniel Valdeperez, Beatriz Pelaz, Neus Feliu, Norbert Hampp, Christoph Riethmüller, Henning Vieker, Natalie Frese, Armin Gölzhäuser, Michael Simonich, Robert L Tanguay, Xing-Jie Liang, Wolfgang J Parak
Exposure of cells to colloidal nanoparticles (NPs) can have concentration-dependent harmful effects. Mostly, such effects are monitored with biochemical assays or probes from molecular biology, i.e. viability assays, gene expression profiles, etc., neglecting that the presence of NPs can also drastically affect cellular morphology. In the case of polymer-coated Au NPs we demonstrate that upon NP internalization, cells undergo lysosomal swelling, alterations in mitochondrial morphology, disturbances in actin and tubulin cytoskeleton and associated signaling, and reduction of focal adhesion contact area and number of filopodia...
June 22, 2017: ACS Nano
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