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transplant infetion

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https://www.readbyqxmd.com/read/27794456/infections-of-the-central-nervous-system-following-unrelated-donor-umbilical-cord-blood-transplantation-or-hla-matched-sibling-transplantation
#1
Aitana Balaguer, Luis Bataller, Ignacio Lorenzo, Isidro Jarque, Miguel Salavert, Eva González, José Luis Piñana, Teresa Sevilla, Pau Montesinos, Gloria Iacoboni, Nuria Muelas, Samuel Romero, Carlos Carretero, Juan Montoro, Maria Jose Ibáñez-Juliá, Guillermo Sanz, Miguel Ángel Sanz, Jaime Sanz
We analyzed the incidence, clinical characteristics, prognostic factors and outcome of CNS infections in consecutive patients with receiving umbilical cord blood transplantation (UCBT) (n = 343) or HLA-matched sibling donor stem cell transplantation (MST) (n = 366). Thirty-four CNS infections were documented at a median time of 116 days after transplant (range, 7-1161). The cumulative incidence (CI) risk of developing a CNS infection was 0.6% at day +30, 2.3% at day +90 and 4.9% at 5 years. The 5-year CI of CNS infection was 8...
October 26, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/235488/t-lymphocyte-function-as-the-principal-target-of-lymphocytic-choriomeningitis-virus-induced-immunosuppression
#2
K Bro-Jorgensen, F Güttler, P N Jorgensen, M Volkert
Plaque-forming cell responses against sheep erythrocytes, Escherichia coli lipopolysaccharide, pneumococcal polysaccharide, and polyvinylpyrrolidone were examined in mice infected with lymphocytic choriomeningitis virus. A 92 to 96 percent reduction of the thymus-dependent anti-sheep erythrocyte responses was observed 2 to 4 weeks after infection. However, the thymus-independent responses against the three other antigens were close to normal at all stages of the infetion. Studies on allograft immunity of infected C3H mice against DBA/2 mastocytoma cells revealed a severe suppression of the T cell-mediated cytotoxic response which was temporally related to the impaired humoral responsiveness against sheep erythrocytes...
April 1975: Infection and Immunity
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