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https://www.readbyqxmd.com/read/27561836/counterpoint-appropriately-ambiguous-the-disc-osteophyte-complex
#1
J S Ross
No abstract text is available yet for this article.
August 25, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27509467/unsuspected-cervical-osteophytes-and-complex-endoscopy-there-is-cause-for-concern
#2
Fabio Sbaraglia, Giorgia Spinazzola, Guido Costamagna, Maria Sammartino
No abstract text is available yet for this article.
2016: Endoscopy
https://www.readbyqxmd.com/read/27355728/regression-of-anterior-disc-osteophyte-complex-following-cervical-laminectomy-and-fusion-for-cervical-spondylotic-myelopathy
#3
Adedayo O Ashana, Jeremiah R Cohen, Brandon Evans, Langston T Holly
STUDY DESIGN: Retrospective case control study. OBJECTIVE: To investigate whether posterior cervical laminectomy and fusion modifies the natural course of anterior disc-osteophyte complex in patients with multilevel CSM. SUMMARY OF BACKGROUND DATA: Dorsal migration of the spinal cord is the main purported mechanism of spinal cord decompression following cervical laminectomy and fusion but other potential mechanisms have received scant attention in the literature...
June 28, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/26542671/effect-of-antiresorptive-and-anabolic-bone-therapy-on-development-of-osteoarthritis-in-a-posttraumatic-rat-model-of-oa
#4
Cedo M Bagi, Edwin Berryman, David E Zakur, Dean Wilkie, Catharine J Andresen
INTRODUCTION: Osteoarthritis (OA) is a leading cause of disability, but despite the high unmet clinical need and extensive research seeking dependable therapeutic interventions, no proven disease-modifying treatment for OA is currently available. Due to the close interaction and interplay between the articular cartilage and the subchondral bone plate, it has been hypothesized that antiresorptive drugs can also reduce cartilage degradation, inhibit excessive turnover of the subchondral bone plate, prevent osteophyte formation, and/or that bone anabolic drugs might also stimulate cartilage synthesis by chondrocytes and preserve cartilage integrity...
November 6, 2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26458934/complex-cervical-spondylotic-myelopathy-a-report-of-two-cases-and-literature-review
#5
Zhuo Ma, Xun Ma, Huilin Yang, Haoyu Feng, Chen Chen
STUDY DESIGN: A report of two cases with complex cervical spondylotic myelopathy (CSM) and review of the literature. OBJECTIVE: To describe two unique patients with complex CSM due to simultaneous anomalies as anteroposterior compressions of the spinal cord in both upper and lower cervical spine, caused by hypertrophic transverse ligament of atlas (TLA), dysplasia of the posterior arch of atlas, disc herniation, hypertrophic ligamentum flavum and osteophytes. METHODS: We present such two cases with clinical, imageological presentations, and describe the surgical procedure, to which both patients responded favorably...
May 2016: European Spine Journal
https://www.readbyqxmd.com/read/26362437/differential-interactive-effects-of-cartilage-traumatization-and-blood-exposure-in-vitro-and-in-vivo
#6
Helga Joos, Frank Leucht, Jana Riegger, Cathrin Hogrefe, Jörg Fiedler, Lutz Dürselen, Heiko Reichel, Anita Ignatius, Rolf E Brenner
BACKGROUND: Sport injuries of the knee often lead to posttraumatic arthritis. In addition to direct damage of the cartilage, trauma-associated intra-articular bleeding may cause hemarthrosis. Both blood exposure and trauma are known to induce cell death and inflammation and to enhance proteoglycan release in cartilage. HYPOTHESIS: Blood exposure increases chondrocyte death as well as inflammatory and degenerative processes in traumatized cartilage. STUDY DESIGN: Controlled laboratory study...
November 2015: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/25746115/predictors-of-intramedullary-lesion-expansion-rate-on-mr-images-of-patients-with-subaxial-spinal-cord-injury
#7
Elizabeth Le, Bizhan Aarabi, David S Hersh, Kathirkamanthan Shanmuganathan, Cara Diaz, Jennifer Massetti, Noori Akhtar-Danesh
OBJECT Studies of preclinical spinal cord injury (SCI) in rodents indicate that expansion of intramedullary lesions (IMLs) seen on MR images may be amenable to neuroprotection. In patients with subaxial SCI and motor-complete American Spinal Injury Association (ASIA) Impairment Scale (AIS) Grade A or B, IML expansion has been shown to be approximately 900 μm/hour. In this study, the authors investigated IML expansion in a cohort of patients with subaxial SCI and AIS Grade A, B, C, or D. METHODS Seventy-eight patients who had at least 2 MRI scans within 6 days of SCI were enrolled...
June 2015: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/25504962/obesity-and-osteoarthritis-more-than-just-wear-and-tear-pivotal-roles-for-inflamed-adipose-tissue-and-dyslipidaemia-in-obesity-induced-osteoarthritis
#8
REVIEW
Eva Thijssen, Arjan van Caam, Peter M van der Kraan
OA is a degenerative joint disease characterized by articular cartilage degradation, osteophyte formation, synovitis, and subchondral bone sclerosis. One of OAs main risk factors is obesity. To date, it is not fully understood how obesity results in OA. Historically, this link was ascribed to excessive joint loading as a result of increased body weight. However, the association between obesity and OA in non-weight-bearing joints suggests a more complex aetiology for obesity-induced OA. In the present review, the link between obesity and OA is discussed...
April 2015: Rheumatology
https://www.readbyqxmd.com/read/25469492/regression-of-anterior-disc-osteophyte-complex-following-cervical-laminectomy-and-fusion-for-cervical-spondylotic-myelopathy
#9
Adedayo O Ashana, Jeremiah R Cohen, Brandon Evans, Langston T Holly
STUDY DESIGN: Retrospective case control study. OBJECTIVE: To investigate whether posterior cervical laminectomy and fusion modifies the natural course of anterior disc-osteophyte complex in patients with multilevel CSM. SUMMARY OF BACKGROUND DATA: Dorsal migration of the spinal cord is the main purported mechanism of spinal cord decompression following cervical laminectomy and fusion but other potential mechanisms have received scant attention in the literature...
December 2, 2014: Journal of Spinal Disorders & Techniques
https://www.readbyqxmd.com/read/25035839/intraarticular-injections-corticosteroid-hyaluronic-acid-platelet-rich-plasma-for-the-knee-osteoarthritis
#10
REVIEW
Egemen Ayhan, Hayrettin Kesmezacar, Isik Akgun
Osteoarthritis (OA) is a complex "whole joint" disease pursued by inflammatory mediators, rather than purely a process of "wear and tear". Besides cartilage degradation, synovitis, subchondral bone remodeling, degeneration of ligaments and menisci, and hypertrophy of the joint capsule take parts in the pathogenesis. Pain is the hallmark symptom of OA, but the extent to which structural pathology in OA contributes to the pain experience is still not well known. For the knee OA, intraarticular (IA) injection (corticosteroids, viscosupplements, blood-derived products) is preferred as the last nonoperative modality, if the other conservative treatment modalities are ineffective...
July 18, 2014: World Journal of Orthopedics
https://www.readbyqxmd.com/read/24938198/the-sources-of-pain-in-osteoarthritis-a-pathophysiological-review
#11
REVIEW
F Salaffi, A Ciapetti, M Carotti
The pain of osteoarthritis (OA) has multifaceted etiologies within and outside the joint. It is believed to be driven by both nociceptive and neuropathic mechanisms, as well as abnormal excitability in the pain pathways of the peripheral and central nervous system. Inflammation in the joint triggers a cascade of events that leads to peripheral sensitization, increased sensitivity of nociceptive primary afferent neurons, and hyperexcitability of the nociceptive neurons in the central nervous system. Pain receptors have been found in the synovium, ligaments, capsule, subchondral bone and surrounding tissues, with the exception of articular cartilage...
June 6, 2014: Reumatismo
https://www.readbyqxmd.com/read/24820146/wnt-signaling-in-ankylosing-spondylitis
#12
REVIEW
Maripat Corr
The mechanisms that lead to bony fusion in ankylosing spondylitis (AS) are yet to be fully defined. In recent years, there have been several advances in our understanding of this complex disease. Here, the potential impact of the Wnt signaling pathway will be discussed. This pathway is involved in bone morphogenesis and homeostasis. Perturbations in the normal regulation have been implicated in abnormal bone formation (e.g., osteophytes). Levels of Wnt regulatory proteins like Dickkopf have been investigated as potential biomarkers of disease...
June 2014: Clinical Rheumatology
https://www.readbyqxmd.com/read/24815367/cortical-shell-unwrapping-for-vertebral-body-abnormality-detection-on-computed-tomography
#13
Jianhua Yao, Joseph E Burns, Hector Muñoz, Ronald M Summers
The vertebral body is the main axial load-bearing structure of the spinal vertebra. Assessment of acute injury and chronic deformity of the vertebral body is difficult to assess accurately and quantitatively by simple visual inspection. We propose a cortical shell unwrapping method to examine the vertebral body for injury such as fractures and degenerative osteophytes. The spine is first segmented and partitioned into vertebrae. Then the cortical shell of the vertebral body is extracted using deformable dual-surface models...
October 2014: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/24556480/radiographic-clinical-and-magnetic-resonance-imaging-analysis-of-insertional-achilles-tendinopathy
#14
Priya Ponnapula Sundararajan, Troy Scott Wilde
The surgical correction of insertional Achilles tendinopathy (IAT) repair typically involves tendon debridement, osteophyte removal, lengthening of the gastroc-soleus complex, and resection of the posterior superior calcaneal eminence. Limited evidence has supported decompression of the superior calcaneal prominence, because this step has had a pronounced association with the surgical treatment of Haglund's syndrome. To appreciate the posterior calcaneal abnormality, 20 lateral weightbearing radiographs of asymptomatic patients were compared with 20 lateral weightbearing radiographs of patients with symptomatic IAT...
March 2014: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/24490089/inadvertent-subdural-injection-during-cervical-transforaminal-epidural-steroid-injection
#15
Kesavan Sadacharam, Jeffrey D Petersohn, Michael S Green
Serious complications following cervical epidural steroid injection are rare. Subdural injection of local anesthetic and steroid represents a rare but potentially life threatening complication. A patient presented with left sided cervical pain radiating into the left upper extremity with motor deficit. MRI showed absent lordosis with a broad left paramedian disc-osteophyte complex impinging the spinal cord at C5-6. During C5-6 transforaminal epidural steroid injection contrast in AP fluoroscopic view demonstrated a subdural contrast pattern...
2013: Case Reports in Anesthesiology
https://www.readbyqxmd.com/read/24449579/brief-report-carboxypeptidase-b-serves-as-a-protective-mediator-in-osteoarthritis
#16
Christin M Lepus, Jason J Song, Qian Wang, Catriona A Wagner, Tamsin M Lindstrom, Constance R Chu, Jeremy Sokolove, Lawrence L Leung, William H Robinson
OBJECTIVE: We previously demonstrated that carboxypeptidase B (CPB) protects against joint erosion in rheumatoid arthritis by inactivating complement component C5a. We also found that levels of CPB are abnormally high in the synovial fluid of individuals with another joint disease, osteoarthritis (OA). We undertook this study to investigate whether CPB plays a role in the pathogenesis of OA. METHODS: We compared the development of OA in CPB-deficient (Cpb2(-/-) ) mice and wild-type mice by subjecting them to medial meniscectomy and histologically assessing cartilage damage, osteophyte formation, and synovitis in the stifle joints 4 months later...
January 2014: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/24285494/the-coupling-of-bone-and-cartilage-turnover-in-osteoarthritis-opportunities-for-bone-antiresorptives-and-anabolics-as-potential-treatments
#17
REVIEW
M A Karsdal, A C Bay-Jensen, R J Lories, S Abramson, T Spector, P Pastoureau, C Christiansen, M Attur, K Henriksen, S R Goldring, V Kraus
Osteoarthritis (OA) is the most common form of arthritic disease, and a major cause of disability and impaired quality of life in the elderly. OA is a complex disease of the entire joint, affecting bone, cartilage and synovium that thereby presents multiple targets for treatment. This manuscript will summarise emerging observations from cell biology, preclinical and preliminary clinical trials that elucidate interactions between the bone and cartilage components in particular. Bone and cartilage health are tightly associated...
February 2014: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/24158743/amputation-versus-functional-reconstruction-in-the-management-of-complex-hind-foot-injuries-caused-by-land-mine-explosions-a-long-term-retrospective-comparison
#18
COMPARATIVE STUDY
Bahtiyar Demiralp, Tolga Ege, Ozkan Kose, Yuksel Yurttas, Mustafa Basbozkurt
The purpose of this study is to compare the long-term clinical outcomes of patients who were treated with either hind foot reconstruction or amputation in complex hind foot injuries accompanied with bone and soft tissue loss due to land-mine explosions. Between 1994 and 2004, all patients with hind foot complex injuries due to land-mine explosion, who were operated in our clinic, were enrolled to the study. All patients were evaluated with Short-Form 36 (SF-36), Foot and Ankle Disability Index (FADI) and Body Image Quality of Life Inventory (BIQLI) after a mean of 15...
May 2014: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/24122333/carboxypeptidase-b-serves-as-a-protective-mediator-in-osteoarthritis
#19
Christin M Lepus, Jason J Song, Qian Wang, Catriona A Wagner, Tamsin M Lindstrom, Constance R Chu, Jeremy Sokolove, Lawrence L Leung, William H Robinson
Objective: We previously demonstrated that carboxypeptidase B (CPB) protects against joint erosion in rheumatoid arthritis by inactivating complement component C5a. We also found that levels of CPB are abnormally high in the synovial fluid of individuals with another joint disease, osteoarthritis (OA). In this study, we investigated whether CPB has a role in the pathogenesis of OA. Methods: We compared the development of OA in CPB-deficient (Cpb2(-/-) ) mice and wild-type mice by subjecting them to medial meniscectomy and four months later histologically assessing cartilage damage, osteophyte formation, and synovitis in the mouse stifle joints...
October 7, 2013: Arthritis and Rheumatism
https://www.readbyqxmd.com/read/23813020/alterations-of-the-subchondral-bone-in-osteochondral-repair-translational-data-and-clinical-evidence
#20
REVIEW
P Orth, M Cucchiarini, D Kohn, H Madry
Alterations of the subchondral bone are pathological features associated with spontaneous osteochondral repair following an acute injury and with articular cartilage repair procedures. The aim of this review is to discuss their incidence, extent and relevance, focusing on recent knowledge gained from both translational models and clinical studies of articular cartilage repair. Efforts to unravel the complexity of subchondral bone alterations have identified (1) the upward migration of the subchondral bone plate, (2) the formation of intralesional osteophytes, (3) the appearance of subchondral bone cysts, and (4) the impairment of the osseous microarchitecture as potential problems...
June 28, 2013: European Cells & Materials
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