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https://www.readbyqxmd.com/read/27933728/sequential-change-detection-and-monitoring-of-temporal-trends-in-random-effects-meta-analysis
#1
Samson Henry Dogo, Allan Clark, Elena Kulinskaya
Temporal changes in magnitude of effect sizes reported in many areas of research are a threat to the credibility of the results and conclusions of meta-analysis. Numerous sequential methods for meta-analysis have been proposed to detect changes and monitor trends in effect sizes so that meta-analysis can be updated when necessary and interpreted based on the time it was conducted. The difficulties of sequential meta-analysis under the random-effects model are caused by dependencies in increments introduced by the estimation of the heterogeneity parameter τ(2) ...
December 8, 2016: Research Synthesis Methods
https://www.readbyqxmd.com/read/27933679/supplementation-with-nutrients-modulating-insulin-like-growth-factor-1-negatively-correlated-with-changes-in-the-levels-of-pro-inflammatory-cytokines-in-community-dwelling-elderly-people-at-risk-of-undernutrition
#2
M Kim, M Kim, Y J Lee, H J Song, J K Shim, D H Chang, W K Yu, S-H Lee, J H Lee
BACKGROUND: Suboptimal nutrition accompanied by chronic low-grade increases in circulating cytokine levels is more common in elderly people. We explored the improvement in nutritional status, especially in the level of insulin-like growth factor-1 (IGF-1) and its relationship with changes in circulating cytokine levels, after providing extra protein and energy content to community-dwelling older adults at risk of undernutrition. METHODS: Sixty nondiabetic subjects, aged ≥65 years and living independently in a community for elderly people, with a serum pre-albumin level ≤30 mg dL(-1) and a body mass index <25 kg m(-2) , were recruited...
December 9, 2016: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/27933678/trends-in-serious-quit-attempts-in-the-united-states-2009-2014
#3
Joe G Gitchell, Saul Shiffman, Mark A Sembower
BACKGROUND AND AIMS: Quitting smoking is the most potent way to reduce the health risks associated with smoking cigarettes, and public health objectives in the USA include dramatic increases in the proportion of smokers making a serious quit attempt each year. The U.S. Centers for Disease Control and Prevention (CDC) has, since 2000, set as its Healthy People 2020 objective to get 80% of smokers to make a serious quit attempt per year. This study assessed the trend in quit attempts from 2009 to 2014...
December 9, 2016: Addiction
https://www.readbyqxmd.com/read/27933667/a-mobile-web-based-system-can-improve-positive-airway-pressure-adherence
#4
Jordanna M Hostler, Karen L Sheikh, Teotimo F Andrada, Andrei Khramtsov, Paul R Holley, Aaron B Holley
SleepMapper is a mobile, web-based system that allows patients to self-monitor their positive airway pressure therapy, and provides feedback and education in real time. In addition to the usual, comprehensive support provided at our clinic, we gave the SleepMapper to 30 patients initiating positive airway pressure. They were compared with patients initiating positive airway pressure at our clinic without SleepMapper (controls) to determine whether SleepMapper affected adherence. A total of 61 patients had polysomnographic and adherence data analysed, 30 were given SleepMapper and 31 received our standard of care...
December 8, 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/27933666/risk-of-stroke-and-recurrence-after-af-ablation-in-patients-with-an-initial-event-free-period-of-12-months
#5
Simon Kochhäuser, Pouria Alipour, Tanjah Haig-Carter, Kathleen Trought, Philip Hache, Yaariv Khaykin, Zaev Wulffhart, Alfredo Pantanomd, Bernice Tsang, David Birnie, Atul Verma
INTRODUCTION: Because of the unclear prognostic effects of ablation of atrial fibrillation (AF), oral anticoagulation (OAC) is often continued after ablation even in asymptomatic patients. We sought to determine the frequency of stroke and AF recurrence in patients on and off therapeutic OAC one year after a successful AF ablation. METHODS AND RESULTS: Patients that underwent AF ablation and were free of AF 12 months after ablation were selected from our AF database...
December 9, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27933656/change-in-trabecular-bone-score-tbs-with-antiresorptive-therapy-does-not-predict-fracture-in-women-the-manitoba-bmd-cohort
#6
William D Leslie, Sumit R Majumdar, Uzanne N Morin, Didier Hans, Lisa M Lix
Bone mineral density (BMD) and trabecular bone score (TBS), along with additional clinical risk factors, can be used to identify individuals at high fracture risk. Whether change in TBS in untreated or treated women independently affects fracture risk is unclear. Using the Manitoba (Canada) DXA Registry containing all BMD results for the population we identified 9044 women age >40 years with two consecutive DXA scans and who were not receiving osteoporosis treatment at baseline (baseline mean age 62 ± 10 years)...
December 8, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27933650/up-regulation-of-microrna-133a-inhibits-the-mek-erk-signaling-pathway-to-promote-cell-apoptosis-and-enhance-radio-sensitivity-by-targeting-egfr-in-esophageal-cancer-in-vivo-and-in-vitro
#7
Qing-Shan Yang, Li-Peng Jiang, Chun-Yan He, Yu-Na Tong, Yuan-Yuan Liu
This study aims to explore how microRNA-133a (miR-133a) affects cell apoptosis and radio-sensitivity by targeting EGFR via regulating MEK/ERK pathway in esophageal cancer (EC). A total of 358 EC patients were selected and assigned into the resistant and sensitive groups. Human EC KYSE 150 cell line was assigned into the blank, negative control (NC), miR-133a mimic, miR-133a inhibitors, si-EGFR, miR-133a inhibitors + si-EGFR groups after transfection. MiR-133a and EGFR mRNA expressions were detected by qRT-PCR and EGFR, MEK/ERK pathway-related protein expressions were detected by Western blotting...
December 8, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27933637/association-of-temporal-variations-in-staffing-with-hospital-acquired-pressure-injury-in-military-hospitals
#8
Patricia A Patrician, Mary S McCarthy, Pauline Swiger, Dheeraj Raju, Sara Breckenridge-Sproat, Xiaogang Su, Kelly H Randall, Lori A Loan
To more precisely evaluate the effects of nurse staffing on hospital-acquired pressure injury (HAPI) development, data on nursing care hours per patient day (NCHPPD), nursing skill mix, patient turnover (i.e., admissions, transfers, and discharges), and patient acuity were merged with patient information from pressure injury prevalence surveys that were collected annually for the Military Nursing Outcomes Database (MilNOD) project. The MilNOD included staffing and adverse events from 56 medical-surgical, stepdown, and critical care units in 13 military hospitals over a 4-year-period...
December 9, 2016: Research in Nursing & Health
https://www.readbyqxmd.com/read/27933615/immediate-release-versus-controlled-release-carbamazepine-in-the-treatment-of-epilepsy
#9
REVIEW
Graham Powell, Matthew Saunders, Alexandra Rigby, Anthony G Marson
BACKGROUND: Carbamazepine (CBZ) is a commonly used drug for epilepsy that is associated with troublesome adverse events including dizziness, double vision, drowsiness, poor co-ordination and unsteadiness. These adverse events often occur during peaks in drug plasma concentration. These adverse events may limit the daily dose of CBZ that can be tolerated and reduce the chances of seizure control in patients who require high doses. A controlled-release formulation of CBZ delivers the same dose over a longer period of time when compared to a standard immediate-release formulation, thereby reducing post-dose peaks in CBZ plasma concentration and potentially reducing adverse events...
December 8, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27933580/headache-service-quality-evaluation-of-quality-indicators-in-14-specialist-care-centres
#10
Sara Schramm, Derya Uluduz, Raquel Gil Gouveia, Rigmor Jensen, Aksel Siva, Ugur Uygunoglu, Giorgadze Gvantsa, Maka Mania, Mark Braschinsky, Elena Filatova, Nina Latysheva, Vera Osipova, Kirill Skorobogatykh, Julia Azimova, Andreas Straube, Ozan Emre Eren, Paolo Martelletti, Valerio De Angelis, Andrea Negro, Mattias Linde, Knut Hagen, Aleksandra Radojicic, Jasna Zidverc-Trajkovic, Ana Podgorac, Koen Paemeleire, Annelien De Pue, Christian Lampl, Timothy J Steiner, Zaza Katsarava
BACKGROUND: The study was a collaboration between Lifting The Burden (LTB) and the European Headache Federation (EHF). Its aim was to evaluate the implementation of quality indicators for headache care Europe-wide in specialist headache centres (level-3 according to the EHF/LTB standard). METHODS: Employing previously-developed instruments in 14 such centres, we made enquiries, in each, of health-care providers (doctors, nurses, psychologists, physiotherapists) and 50 patients, and analysed the medical records of 50 other patients...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27933515/serum-bilirubin-concentrations-and-incident-coronary-heart-disease-risk-among-patients-with-type-2-diabetes-the-dongfeng-tongji-cohort
#11
Jing Wang, Xiaofen Wu, Yaru Li, Xu Han, Hua Hu, Fei Wang, Caizheng Yu, Xiulou Li, Kun Yang, Jing Yuan, Ping Yao, Xiaoping Miao, Sheng Wei, Youjie Wang, Weihong Chen, Yuan Liang, Huan Guo, Handong Yang, Tangchun Wu, Xiaomin Zhang, Meian He
AIMS: Elevated serum bilirubin levels are associated with decreased coronary heart disease (CHD) risk in cross-sectional studies among diabetic patients, but prospective evidence is limited. We investigated the relationship of serum bilirubin levels with incident CHD risk among type 2 diabetes patients. METHODS: In a prospective study of 2918 type 2 diabetes embedded in the Dongfeng-Tongji cohort, serum total bilirubin (TBil), direct bilirubin (DBil), and indirect bilirubin (IBil) were measured at baseline...
December 8, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27933415/association-between-gamma-glutamyltransferase-and-albuminuria-in-nondiabetic-adults-with-normal-renal-function
#12
Sun-Hye Ko, Myong Ki Baeg, Kyung-Do Han, Seung-Yeon Ko, Sae-Bom Shin, Seung-Hyun Ko, Yu-Bae Ahn
BACKGROUND: Serum gamma-glutamyltransferase (GGT) has been associated with albuminuria in diabetes patients, but it has not been investigated in the general population. We aimed to investigate the association between serum GGT and albuminuria in the nondiabetic Korean population with normal kidney function. METHODS: Study participants (3948; 1549 men and 2399 women) with an estimated glomerular filtration rate ≥60 mL/min/1.73 m(2) were analyzed from the fifth Korean National Health and Nutrition Examination Survey (2011)...
December 9, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27933409/imaging-trends-in-suspected-appendicitis-a-canadian-perspective
#13
Victoria F Tan, Michael N Patlas, Douglas S Katz
PURPOSE: The purpose of our study was to assess trends in the imaging of suspected appendicitis in adult patients in emergency departments of academic centers in Canada. METHODS: A questionnaire was sent to all 17 academic centers in Canada to be completed by a radiologist who works in emergency radiology. The questionnaires were sent and collected over a period of 4 months from October 2015 to February 2016. RESULTS: Sixteen centers (94%) responded to the questionnaire...
December 8, 2016: Emergency Radiology
https://www.readbyqxmd.com/read/27933385/outcomes-and-prognostic-factors-for-squamous-cell-carcinoma-of-the-oral-tongue-in-young-adults-a-single-institution-case-matched-analysis
#14
Pierre Blanchard, Farid Belkhir, Stéphane Temam, Clément El Khoury, Francesca De Felice, Odile Casiraghi, Anna Patrikidou, Haitham Mirghani, Antonin Levy, Caroline Even, Philippe Gorphe, France Nguyen, François Janot, Yungan Tao
There is controversy regarding prognosis and treatment of young patients with oral cavity cancer compared to their older counterparts. We conducted a retrospective case-matched analysis of all adult patients younger than 40 years and treated at our institution for a squamous cell carcinoma of the oral cavity. Only non-metastatic adult patients (age >18) with oral tongue cancer were eventually included and matched 1:1 with patients over 40 years of age, at least 20 years older than the cases, with same T and N category and treatment period...
December 8, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27933377/radiofrequency-ablation-of-hepatocellular-carcinoma-with-a-nodule-in-nodule-appearance-long-term-follow-up-and-clinical-implications
#15
Tae Wook Kang, Hyunchul Rhim, Kyoung Doo Song, Min Woo Lee, Dong Ik Cha, Sang Yun Ha, Joong Hyun Ahn
PURPOSE: Hepatocellular carcinoma (HCC) with a "nodule-in-nodule" (NIN) appearance has unique histological characteristics as an early HCC. We assessed long-term therapeutic outcomes of radiofrequency ablation (RFA) in HCC patients considering this appearance. MATERIALS AND METHODS: Our Institutional Review Board approved this retrospective study, and the requirement for written informed consent was waived. Between May 2006 and April 2012, a total of 572 patients underwent RFA for single HCC as a first-line treatment...
December 8, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27933342/prediction-of-nk-cell-licensing-level-in-selection-of-hematopoietic-stem-cell-donor-initial-results
#16
Marta Rogatko-Koroś, Renata Mika-Witkowska, Katarzyna Bogunia-Kubik, Barbara Wysoczańska, Emilia Jaskuła, Katarzyna Kościńska, Klaudia Nestorowicz, Joanna Dziopa, Urszula Szlendak, Sławomir Gwozdowicz, Elżbieta Graczyk-Pol, Andrzej Lange, Jacek Nowak
Natural killer (NK) cell licensing status depends on clonal expression of inhibitory killer cell immunoglobulin-like receptors (iKIR) and short term HLA environment. Licensed NK cells are more efficient in tumor killing than unlicensed NK cells. Cognate KIR-HLA pairs in hematopoietic stem cell transplant (HSCT) donor and recipient are decisive for the possible change in the NK cell licensing status after HSCT. We assessed clinical outcomes in 297 patients with lymphoproliferative or myeloproliferative malignancies, or myelodysplastic syndrome in a model with upward licensing, downward resetting, and unchanged licensing genetics status after T cell replate HSCT from unrelated donors...
December 8, 2016: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/27933307/impact-of-intravenous-infusion-time-on-aav8-vector-pharmacokinetics-safety-and-liver-transduction-in-cynomolgus-macaques
#17
Jenny A Greig, Jayme Ml Nordin, Erin Bote, Leah Makaron, Mason E Garnett, Lisa M Kattenhorn, Peter Bell, Tamara Goode, James M Wilson
Systemically delivered adeno-associated viral (AAV) vectors are now in early-phase clinical trials for a variety of diseases. While there is a general consensus on inclusion and exclusion criteria for each of these trials, the conditions under which vectors are infused vary significantly. In this study, we evaluated the impact of intravenous infusion rate of AAV8 vector in cynomolgus macaques on transgene expression, vector clearance from the circulation, and potential activation of the innate immune system...
2016: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/27933262/software-project-management-tools-in-global-software-development-a-systematic-mapping-study
#18
Saad Yasser Chadli, Ali Idri, Joaquín Nicolás Ros, José Luis Fernández-Alemán, Juan M Carrillo de Gea, Ambrosio Toval
Global software development (GSD) which is a growing trend in the software industry is characterized by a highly distributed environment. Performing software project management (SPM) in such conditions implies the need to overcome new limitations resulting from cultural, temporal and geographic separation. The aim of this research is to discover and classify the various tools mentioned in literature that provide GSD project managers with support and to identify in what way they support group interaction. A systematic mapping study has been performed by means of automatic searches in five sources...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933228/who-inrud-prescribing-indicators-and-prescribing-trends-of-antibiotics-in-the-accident-and-emergency-department-of-bahawal-victoria-hospital-pakistan
#19
Muhammad Atif, Muhammad Azeem, Muhammad Rehan Sarwar, Samia Shahid, Sidra Javaid, Huria Ikram, Uzma Baig, Shane Scahill
A descriptive, retrospective and cross sectional study was conducted to assess the prescribing practices and antibiotic use patterns in the Accident and Emergency department of the Bahawal Victoria Hospital, Bahawalpur, Pakistan. A sample of 4320 prescriptions (systematic random sampling) was drawn out of a total of 1,080,000 prescriptions written during the period 1st January-31st December 2014. The standard World Health Organization/International Network for Rational Use of Drugs prescribing indicators were used to determine the prescribing practices of physicians...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933217/poly-isoprenecarboxylates-from-glucose-via-anhydromevalonolactone
#20
Nicolas R Ball-Jones, Grant W Fahnhorst, Thomas R Hoye
A short and efficient synthesis of a series of isoprenecarboxylic acid esters (ICAEs) and their corresponding polymers is presented. The base-catalyzed eliminative ring-opening of anhydromevalonolactone (3) provides isoprenecarboxylic acid (6-H), which was further transformed to the ICAEs. Reversible addition-fragmentation chain-transfer (RAFT) polymerization was used to synthesize high molecular weight (>100 kg mol(-1)) poly(isoprenecarboxylates) with dispersities (Đ) of ca. 1.5. The glass transition temperatures (Tg) and entanglement molecular weights (Me) of the poly(isoprenecarboxylates) were determined and showed similar trends to the Tg and Me values for analogous poly(acrylate esters)...
October 18, 2016: ACS Macro Letters
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