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endobronchial valves

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https://www.readbyqxmd.com/read/27920518/significant-lung-volume-reduction-with-endobronchial-valves-in-a-patient-despite-the-presence-of-microcollaterals-masked-by-low-flow-chartis-phenotype
#1
Yan Yin, Gang Hou, Felix J Herth, Xiao-Bo Wang, Qiu-Yue Wang, Jian Kang
Satisfactory functional outcomes following bronchoscopic lung volume reduction (BLVR) using endobronchial valves (EBVs) depend on the absence of collateral ventilation (CV) between the target and adjunct lobes. The Chartis system has proven to be useful for determining whether CV is present or absent, but this system can also erroneously indicate the absence of CV, which can lead to BLVR failure. Here, we describe low-flow Chartis phenotype in the target lobe resulted in difficult judgment of existence of CV...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27814898/endobronchial-valve-therapy-for-a-refractory-air-leak-after-lung-transplantation-in-a-patient-with-multiple-connective-tissue-disorders
#2
John R Spratt, Eitan Podgaetz, Gabriel Loor, Sara J Shumway
No abstract text is available yet for this article.
October 24, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27806368/endobronchial-valves-for-emphysema-time-to-push-the-envelope
#3
Zaid Zoumot, Samuel V Kemp, Pallav L Shah
No abstract text is available yet for this article.
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27806152/bronchoscopic-management-of-prolonged-air-leaks-with-endobronchial-valves-in-a-veteran-population
#4
Lorraine D Cornwell, Ramola Panchal, Faisal G Bakaeen, Shuab Omer, Ourania Preventza, Donald R Lazarus, Roberto F Casal
No abstract text is available yet for this article.
November 2, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27797610/endobronchial-valves-as-a-treatment-for-emphysema-moving-out-of-the-shadow-of-lung-volume-reduction-surgery
#5
Nicholas S Hopkinson
No abstract text is available yet for this article.
November 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27776598/endobronchial-valve-treatment-of-destructive-multidrug-resistant-tuberculosis
#6
A Levin, S Sklyuev, I Felker, E Tceymach, D Krasnov
BACKGROUND: In accordance with the existing hypothesis, the application of an endobronchial valve (EbV) leads to selective curative atelectasis of the affected part of the lung, contributing to early closure of cavities. OBJECTIVE: To assess the effect of EbV treatment on the course of tuberculosis (TB). METHODS: We compared the efficacy of EbV treatment and complex second-line treatment in treating patients with destructive pulmonary multidrug-resistant TB (MDR-TB)...
November 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27742781/endobronchial-valves-for-bronchopleural-fistula-pitfalls-and-principles
#7
Dany Gaspard, Thaddeus Bartter, Ziad Boujaoude, Haroon Raja, Rohan Arya, Nikhil Meena, Wissam Abouzgheib
BACKGROUND: Placement of endobronchial valves for bronchopleural fistula (BPF) is not always straightforward. A simple guide to the steps for an uncomplicated procedure does not encompass pitfalls that need to be understood and overcome to maximize the efficacy of this modality. OBJECTIVES: The objective of this study was to discuss examples of difficult cases for which the placement of endobronchial valves was not straightforward and required alterations in the usual basic steps...
October 14, 2016: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/27739872/the-clinical-significance-of-collateral-ventilation
#8
Peter B Terry, Richard J Traystman
Oxygen delivery and carbon dioxide removal being critical to cell survival, mammals have developed collateral vascular and ventilation systems to ensure tissue viability. Collateral ventilation, defined as ventilation of alveoli via pathways that bypass normal airways, is present in humans and many other species. The presence of collateral ventilation can be beneficial in certain disease states, whereas its relative absence can predispose to other diseases. These well defined anatomical pathways contribute little to ventilation in normal humans, but modulate ventilation perfusion imbalance in a variety of diseases, including obstructive diseases, such as asthma and emphysema...
December 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27728916/lobar-collapse-therapy-using-endobronchial-valves-as-a-new-complementary-approach-to-treat-cavities-in-multidrug-resistant-tuberculosis-and-difficult-to-treat-tuberculosis-a-case-series
#9
Lorenzo Corbetta, Ariela Tofani, Flavio Montinaro, Lucio Michieletto, Loris Ceron, Chiara Moroni, Pier Giorgio Rogasi
BACKGROUND: The poor treatment outcomes of multidrug-resistant tuberculosis (TB) and the emergence of extensively drug-resistant TB and extremely and totally drug-resistant TB highlight the urgent need for new antituberculous drugs and other adjuvant treatment approaches. OBJECTIVES: We have treated cavitary tuberculosis by the application of endobronchial one-way valves (Zephyr®; Pulmonx Inc., Redwood City, Calif., USA) to induce lobar volume reduction as an adjunct to drug treatment...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27701180/bilateral-endoscopic-lung-volume-reduction-in-patients-with-severe-emphysema
#10
Franziska C Trudzinski, Philipp M Lepper, Daniela Leppert, Frank Langer, Christian Lensch, Monika Flaig, Robert Bals, Heinrike Wilkens, Peter Minko, Sebastian Fähndrich
Reducing hyperinflated areas in chronic obstructive pulmonary disease, either surgically or endoscopically, leads to improvement of functional parameters. It is unclear if bilateral treatment with endobronchial valves (EBV) aiming at total lobar occlusion is beneficial. The aim of this study was to assess the results after staged bilateral endoscopic treatment with EBV. This is a retrospective analysis of patients with severe airflow obstruction, who were treated bilaterally with EBV in two stages, aiming at subsequent atelectasis...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27693408/lung-volume-reduction-for-emphysema
#11
Pallav L Shah, Felix J Herth, Wouter H van Geffen, Gaetan Deslee, Dirk-Jan Slebos
Advanced emphysema is a lung disease in which alveolar capillary units are destroyed and supporting tissue is lost. The combined effect of reduced gas exchange and changes in airway dynamics impairs expiratory airflow and leads to progressive air trapping. Pharmacological therapies have limited effects. Surgical resection of the most destroyed sections of the lung can improve pulmonary function and exercise capacity but its benefit is tempered by significant morbidity. This issue stimulated a search for novel approaches to lung volume reduction...
September 29, 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27647978/management-of-prolonged-pulmonary-air-leaks-with-endobronchial-valve-placement
#12
Charles Bakhos, Peter Doelken, Stevan Pupovac, Ashar Ata, Tom Fabian
BACKGROUND: Prolonged pulmonary air leaks (PALs) are associated with increased morbidity and extended hospital stay. We sought to investigate the role of bronchoscopic placement of 1-way valves in treating this condition. METHODS: We queried a prospectively maintained database of patients with PAL lasting more than 7 days at a tertiary medical center. Main outcome measures included duration of chest tube placement and hospital stay before and after valve deployment...
July 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/27603781/endoscopic-lung-volume-reduction-using-endobronchial-valves-in-patients-with-severe-emphysema-and-very-low-fev1
#13
Franziska C Trudzinski, Anna J Höink, Daniela Leppert, Sebastian Fähndrich, Heinrike Wilkens, Thomas P Graeter, Frank Langer, Robert Bals, Peter Minko, Philipp M Lepper
BACKGROUND: Patients with a forced expiratory volume in 1 s (FEV1) below 20% of the predicted normal values (pred.) and either homogeneous emphysema or low diffusing capacity for carbon monoxide (DLCO) have a high risk for adverse events including death when undergoing surgical lung volume reduction. OBJECTIVES: We hypothesized that selected patients can benefit from endoscopic lung volume reduction (eLVR) despite a very low FEV1. METHODS: This study is a retrospective analysis of consecutive patients with severe airflow obstruction, an FEV1 ≤20% of pred...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27580428/endobronchial-valve-therapy-in-patients-with-homogeneous-emphysema-results-from-the-impact-study
#14
Arschang Valipour, Dirk-Jan Slebos, Felix Herth, Kaid Darwiche, Manfred Wagner, Joachim H Ficker, Christoph Petermann, Ralf-Harto Hubner, Franz Stanzel, Ralf Eberhardt
RATIONALE: Endobronchial valves (EBV) have been successfully used in patients with severe heterogeneous emphysema to improve lung physiology. Limited available data suggests that EBVs are also effective in homogeneous emphysema. OBJECTIVE: To evaluate the efficacy and safety of EBV in patients with homogeneous emphysema with absence of collateral ventilation assessed by Chartis. METHODS: Prospective, multicenter 1:1 randomized controlled trial of EBV plus standard-of-care (SoC) or (SoC) alone...
August 31, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27577190/predicting-lung-volume-reduction-after-endobronchial-valve-therapy-is-maximized-using-a-combination-of-diagnostic-tools
#15
T David Koster, Eva M van Rikxoort, Ralf-Harto Huebner, Felix Doellinger, Karin Klooster, Jean-Paul Charbonnier, Sri Radhakrishnan, Felix J F Herth, Dirk-Jan Slebos
BACKGROUND: Bronchoscopic lung volume reduction using one-way endobronchial valves (EBVs) has been proven to be effective in patients with severe emphysema. However, the selection of patients without collateral ventilation prior to treatment is critical for procedural success. Collateral ventilation can be assessed directly with the Chartis system or indirectly using computed tomography (CT) fissure analysis. OBJECTIVES: We retrospectively evaluated the diagnostic value of a combination of the quantitative CT interlobar fissure completeness score (FCS) and Chartis in predicting responders to EBV therapy...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27562904/a-long-term-follow-up-investigation-of-endobronchial-valves-in-emphysema-the-live-study-study-protocol-and-six-month-interim-analysis-results-of-a-prospective-five-year-observational-study
#16
Dirk Skowasch, Andreas Fertl, Björn Schwick, Harald Schäfer, Andreas Hellmann, Felix J F Herth
BACKGROUND: Randomized controlled trials indicate that significant lung volume reduction (ELVR) can be obtained with Zephyr® valves by occluding the target lobe in the absence of collateral ventilation, leading to relevant functional benefits in advanced emphysema patients. OBJECTIVES: To observe the long-term effects of endobronchial valve (EBV) implantation in emphysema patients screened by Chartis assessment in the context of daily pulmonology practice. METHODS: The LIVE Study is a prospective, observational, open-label, single-arm, multicenter trial conducted in Germany...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27525462/survival-after-endobronchial-valve-placement-for-emphysema-a-10-year-follow-up-study
#17
Justin Garner, Samuel V Kemp, Tudor P Toma, David M Hansell, Michael I Polkey, Pallav L Shah, Nicolas S Hopkinson
No abstract text is available yet for this article.
August 15, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27510260/endobronchial-valves-to-treat-a-recurrent-giant-emphysematous-bulla-after-bullectomy
#18
Mei Ding, Ya-Dong Gao, Li Dai, Xin Li, Jiong Yang
No abstract text is available yet for this article.
September 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27492521/improvement-of-physical-activity-after-endobronchial-valve-treatment-in-emphysema-patients
#19
Jorine E Hartman, Karin Klooster, Dirk-Jan Slebos, Nick H T Ten Hacken
RATIONALE: Bronchoscopic lung volume reduction using endobronchial valves is a promising treatment for severe emphysema patients without collateral ventilation. Physical activity is an important contributing factor for the autonomy, morbidity and mortality of these patients. OBJECTIVE: We investigated the impact of endobronchial valve treatment on physical activity in severe emphysema patients. METHODS: Physical activity was measured for 7 days by a triaxial accelerometer at baseline and 6 months follow-up after EBV treatment, and compared with standard medical care in a randomized controlled trial...
August 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27454477/endobronchial-valve-migration-a-whistle-blower
#20
Alfonso Fiorelli, Alfonso Reginelli, Mario Santini
No abstract text is available yet for this article.
July 2016: Journal of Bronchology & Interventional Pulmonology
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