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https://www.readbyqxmd.com/read/28694031/in-vivo-induction-of-regulatory-t-cells-promotes-allergen-tolerance-and-suppresses-allergic-contact-dermatitis
#1
Stephen C Balmert, Cara Donahue, John R Vu, Geza Erdos, Louis D Falo, Steven R Little
Allergic contact dermatitis (ACD) is a common T-cell mediated inflammatory skin condition, characterized by an intensely pruritic rash at the site of contact with allergens like poison ivy or nickel. Current clinical treatments use topical corticosteroids, which broadly and transiently suppress inflammation and symptoms of ACD, but fail to address the underlying immune dysfunction. Here, we present an alternative therapeutic approach that teaches the immune system to tolerate contact allergens by expanding populations of naturally suppressive allergen-specific regulatory T cells (Tregs)...
July 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28666216/assessment-of-28-trace-elements-and-17-amino-acid-levels-in-muscular-tissues-of-broiler-chicken-gallus-gallus-suffering-from-arsenic-trioxide
#2
Si-Wen Li, Ying He, Hong-Jing Zhao, Yu Wang, Juan-Juan Liu, Yi-Zhi Shao, Jing-Lun Li, Xiao Sun, Li-Na Zhang, Ming-Wei Xing
The contents of 28 trace elements, 17 amino acid were evaluated in muscular tissues (wings, crureus and pectoralis) of chickens in response to arsenic trioxide (As2O3). A total of 200 one-day-old male Hy-line chickens were fed either a commercial diet (C-group) or an As2O3 supplement diet containing 7.5mg/kg (L-group), 15mg/kg (M-group) or 30mg/kg (H-group) As2O3 for 90 days. The elements content was analyzed by inductively coupled plasma mass spectrometry (ICP-MS). Under As2O3 exposure, the concentration of As were elevated 8...
June 27, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28643849/prevalence-of-exposure-of-heavy-metals-and-their-impact-on-health-consequences
#3
Kanwal Rehman, Fiza Fatima, Iqra Waheed, Muhammad Sajid Hamid Akash
Even in the current era of growing technology, the concentration of heavy metals present in drinking water is still not within the recommended limits as set by the regulatory authorities in different countries of the world. Drinking water contaminated with heavy metals namely; arsenic, cadmium, nickel, chromium, mercury, chromium, zinc and lead is becoming a major health concern for public and health care professionals. Occupational exposure to heavy metals is known to occur by the utilization of these metals in various industrial processes and/or contents including color pigments and alloys...
June 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28539940/horizontal-and-vertical-distribution-of-heavy-metals-in-farm-produce-and-livestock-around-lead-contaminated-goldmine-in-dareta-and-abare-zamfara-state-northern-nigeria
#4
O E Orisakwe, O O Oladipo, G C Ajaezi, N A Udowelle
Background. Hitherto studies in response to the June 2010 lead poisoning, Zamfara State, Nigeria, have focused on clinical interventions without information on livestock and other metals. Objective. This study has investigated the distribution of heavy metals in farm produce and livestock around lead-contaminated goldmine in Dareta and Abare, Zamfara State, Nigeria. Methods. Vegetables, soil, water, blood, and different meat samples were harvested from goat, sheep, cattle, and chicken from Dareta, Abare, and Gusau communities...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28335315/oxidation-of-co-and-methanol-on-pd-ni-catalysts-supported-on-different-chemically-treated-carbon-nanofibers
#5
Juan Carlos Calderón, Miguel Rios Ráfales, María Jesús Nieto-Monge, Juan Ignacio Pardo, Rafael Moliner, María Jesús Lázaro
In this work, palladium-nickel nanoparticles supported on carbon nanofibers were synthesized, with metal contents close to 25 wt % and Pd:Ni atomic ratios near to 1:2. These catalysts were previously studied in order to determine their activity toward the oxygen reduction reaction. Before the deposition of metals, the carbon nanofibers were chemically treated in order to generate oxygen and nitrogen groups on their surface. Transmission electron microscopy analysis (TEM) images revealed particle diameters between 3 and 4 nm, overcoming the sizes observed for the nanoparticles supported on carbon black (catalyst Pd-Ni CB 1:2)...
October 18, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28128086/vesicular-contact-reaction-may-progress-into-erythema-multiforme
#6
Magdalena Czarnecka-Operacz, Dorota Jenerowicz, Joanna Szulczyńska-Gabor, Ewa Teresiak-Mikołajczak, Joanna Szyfter-Harris, Monika Bowszyc-Dmochowska
Dear Editor, Erythema multiforme is considered an acute skin condition, characterized by a self-limiting and sometimes recurrent course. It is regarded as a type IV hypersensitivity reaction associated with certain infections, medications, and other various triggers. Allergic contact dermatitis is in turn a delayed type of induced allergy as a result of cutaneous contact with a specific allergen to which the patient develops specific sensitivity. This type of cutaneous reaction is associated with inflammation manifesting with erythema, edema, and vesicles...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28064036/effects-of-specimen-size-and-mix-ratio-on-the-nickel-migration-behavior-of-landfill-waste-mixed-mortar
#7
M Aminul Haque
Landfill solid waste management system poses the potential source of silent wide-spread heavy metals like nickel poisoning in the entire ecosystem of nearby environment. Nickel containing demolish solid wastes are disposed at landfill zones to a great extent from where nickel migrate into the food chain through the surface water body as well as groundwater. Consequently, nickel exposure may cause different environmental problems. From this sense, it may be an attractive proposal to recycle the waste as a sustainable product...
April 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28059410/enhanced-electrooxidation-of-glucose-at-nano-chitosan-niooh-modified-gc-electrode-fuel-blends-and-hydrocarbon-impurities
#8
Gumaa A El-Nagar, Christina Roth
The current study addresses, for the first time, the promoting effect of some selected fuel blending components, such as methanol (MeOH), ethanol (EtOH) and acetaldehyde (ACTA), on the glucose electrooxidation at a nano-chitosan-NiOOH modified GC electrode (nano-CS-NiOOH/GC). Blending glucose with different molar ratios of MeOH, EtOH and ACTA results in a significant enhancement in the fuel utilization, NiOOH oxidation capacity and turnover number of oxidized glucose molecules compared to the pure fuels. For instance, the use of glucose fuel blends composed of 40% of glucose with 60% of either MeOH, EtOH and ACTA results in 10, 8 and 5 times higher glucose activity of the nano-CS-NiOOH/GC electrode compared to using glucose as a pure fuel, respectively...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28043279/-a-case-of-acute-poisoning-caused-by-ingestion-of-nickel-sulfate
#9
C J Xue, Y J Xia, Q Ye
No abstract text is available yet for this article.
November 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28043274/-high-resolution-ct-features-of-pulmonary-injury-induced-by-acute-nickel-carbonyl-poisoning
#10
S H Jin, Q Zhang, J Wang
No abstract text is available yet for this article.
November 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28029760/evidence-of-sulfate-dependent-anaerobic-methane-oxidation-within-an-area-impacted-by-coalbed-methane-related-gas-migration
#11
Amy L Wolfe, Richard T Wilkin
We evaluated water quality characteristics in the northern Raton Basin of Colorado and documented the response of the Poison Canyon aquifer system several years after upward migration of methane gas occurred from the deeper Vermejo Formation coalbed production zone. Results show persistent secondary water quality impacts related to the biodegradation of methane. We identify four distinct characteristics of groundwater-methane attenuation in the Poison Canyon aquifer: (i) consumption of methane and sulfate and production of sulfide and bicarbonate, (ii) methane loss coupled to production of higher molecular weight (C2+) gaseous hydrocarbons, (iii) patterns of (13)C enrichment and depletion in methane and dissolved inorganic carbon, and (iv) a systematic shift in sulfur and oxygen isotope ratios of sulfate, indicative of microbial sulfate reduction...
January 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/27669512/is-geo-environmental-exposure-a-risk-factor-for-multiple-sclerosis-a-population-based-cross-sectional-study-in-south-western-sardinia
#12
Maria Cristina Monti, Davide Guido, Cristina Montomoli, Claudia Sardu, Alessandro Sanna, Salvatore Pretti, Lorena Lorefice, Maria Giovanna Marrosu, Paolo Valera, Eleonora Cocco
BACKGROUND: South-Western Sardinia (SWS) is a high risk area for Multiple Sclerosis (MS) with high prevalence and spatial clustering; its population is genetically representative of Sardinians and presents a peculiar environment. We evaluated the MS environmental risk of specific heavy metals (HM) and geographical factors such as solar UV exposure and urbanization by undertaking a population-based cross-sectional study in SWS. METHODS: Geochemical data on HM, UV exposure, urbanization and epidemiological MS data were available for all SWS municipalities...
2016: PloS One
https://www.readbyqxmd.com/read/27581664/presentations-to-an-urban-emergency-department-in-switzerland-due-to-acute-%C3%AE-hydroxybutyrate-toxicity
#13
Evangelia Liakoni, Fabio Walther, Christian H Nickel, Matthias E Liechti
BACKGROUND: γ-Hydroxybutyrate (GHB) is a drug of abuse with dose-dependent sedative effects. Systematic data on the acute toxicity of GHB from emergency department (ED) presentations over a long period of time are currently missing from the literature. The present study described the clinical features of GHB toxicity. METHODS: Retrospective case series of GHB intoxications seen in an urban ED. RESULTS: From January 2002 to September 2015, 78 GHB-related intoxication cases were recorded (71 % male patients)...
August 31, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27511528/nickel-catalyzed-transfer-hydrogenation-of-ketones-using-ethanol-as-a-solvent-and-a-hydrogen-donor
#14
Nahury Castellanos-Blanco, Alma Arévalo, Juventino J García
We report a nickel(0)-catalyzed direct transfer hydrogenation (TH) of a variety of alkyl-aryl, diaryl, and aliphatic ketones with ethanol. This protocol implies a reaction in which a primary alcohol serves as a hydrogen atom source and solvent in a one-pot reaction without any added base. The catalytic activity of the nickel complex [(dcype)Ni(COD)] (e) (dcype: 1,2-bis(dicyclohexyl-phosphine)ethane, COD: 1,5-cyclooctadiene), towards transfer hydrogenation (TH) of carbonyl compounds using ethanol as the hydrogen donor was assessed using a broad scope of ketones, giving excellent results (up to 99% yield) compared to other homogeneous phosphine-nickel catalysts...
September 14, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27221878/high-cadmium-levels-in-cured-meat-products-marketed-in-nigeria-implications-for-public-health
#15
Olufunmilayo E Adejumo, Pius S Fasinu, Judith E Odion, Boladale O Silva, Timothy O Fajemirokun
Heavy metals are known to disrupt important physiological processes in living cells, and have been responsible for various pathological conditions with possible contributions to cancer development. Food contamination have been identified as one of the ways humans are exposed to heavy metals. In developing countries like Nigeria, the regulatory framework for enforcing compliance with globally acceptable exposure to deleterious contaminants is poor. In the current study, thirteen samples of cured meat products of diverse origin marketed in South-west Nigeria were evaluated for lead, cadmium, chromium and nickel contents using the atomic absorption spectroscopy technique...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27150911/a-review-of-pitfalls-and-progress-in-chelation-treatment-of-metal-poisonings
#16
REVIEW
Ole Andersen, Jan Aaseth
Most acute and chronic human metal poisonings are due to oral or inhalation exposure. Almost 80% of published animal experiments on chelation in metal poisoning used single or repeated intraperitoneal, intramuscular or intravenous administration of metal and chelator, impeding extrapolation to clinical settings. Intramuscular administration of dimercaptopropanol (BAL) has until now been used in acute arsenic, lead, and mercury poisonings, but repeated BAL administration increased the brain uptake of As, Pb and Hg in experimental animals...
December 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/26900394/health-status-of-male-steel-workers-at-an-electric-arc-furnace-eaf-in-trentino-italy
#17
Roberto Cappelletti, Marcello Ceppi, Justina Claudatus, Valerio Gennaro
BACKGROUND: The aim of this retrospective cohort study was to determine if the workers of an Electric Arc Furnace (EAF), which recycles scrap, had higher mortality and morbidity due to possible exposure to pollutants at work. EAFs do not run on coke ovens. In EAFs 40 % of the particulate matter (PM) is made up of PM 2.5. The foundry dust contained iron, aluminum, zinc, manganese, lead, chromium, nickel, cadmium, mercury, arsenic, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls and dioxins...
2016: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/26648509/a-high-performing-sulfur-tolerant-and-redox-stable-layered-perovskite-anode-for-direct-hydrocarbon-solid-oxide-fuel-cells
#18
Hanping Ding, Zetian Tao, Shun Liu, Jiujun Zhang
Development of alternative ceramic oxide anode materials is a key step for direct hydrocarbon solid oxide fuel cells (SOFCs). Several lanthanide based layered perovskite-structured oxides demonstrate outstanding oxygen diffusion rate, favorable electronic conductivity, and good oxygen surface exchange kinetics, owing to A-site ordered structure in which lanthanide and alkali-earth ions occupy alternate (001) layers and oxygen vacancies are mainly located in [LnOx] planes. Here we report a nickel-free cation deficient layered perovskite, (PrBa)0...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26602295/highly-active-and-durable-methanol-oxidation-electrocatalyst-based-on-the-synergy-of-platinum-nickel-hydroxide-graphene
#19
Wenjing Huang, Hongtao Wang, Jigang Zhou, Jian Wang, Paul N Duchesne, David Muir, Peng Zhang, Na Han, Feipeng Zhao, Min Zeng, Jun Zhong, Chuanhong Jin, Yanguang Li, Shuit-Tong Lee, Hongjie Dai
Active and durable electrocatalysts for methanol oxidation reaction are of critical importance to the commercial viability of direct methanol fuel cell technology. Unfortunately, current methanol oxidation electrocatalysts fall far short of expectations and suffer from rapid activity degradation. Here we report platinum-nickel hydroxide-graphene ternary hybrids as a possible solution to this long-standing issue. The incorporation of highly defective nickel hydroxide nanostructures is believed to play the decisive role in promoting the dissociative adsorption of water molecules and subsequent oxidative removal of carbonaceous poison on neighbouring platinum sites...
November 25, 2015: Nature Communications
https://www.readbyqxmd.com/read/26484131/genome-wide-gene-expression-profiling-of-acute-metal-exposures-in-male-zebrafish
#20
Christine E Baer, Danielle L Ippolito, Naissan Hussainzada, John A Lewis, David A Jackson, Jonathan D Stallings
To capture global responses to metal poisoning and mechanistic insights into metal toxicity, gene expression changes were evaluated in whole adult male zebrafish following acute 24 h high dose exposure to three metals with known human health risks. Male adult zebrafish were exposed to nickel chloride, cobalt chloride or sodium dichromate at concentrations corresponding to their respective 96 h LC20, LC40 and LC60 (i.e. 96 h concentrations at which 20%, 40% and 60% lethality is expected, respectively). Histopathology was performed on a subset of metal-exposed zebrafish to phenotypically anchor transcriptional changes associated with each metal exposure...
December 2014: Genomics Data
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