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Mogammad Shaheed Soeker, Olumide Ayoola Olaoye
BACKGROUND: Stroke has been identified as a global cause of neurological disability with a resultant burden shared not only by the survivor but also by society. The resumption of an individual's role as a worker after having a stroke, is an important rehabilitation goal. South-West Nigeria has experienced a high incidence and prevalence of stroke, leaving a quarter of survivors with severe disabilities and difficulties in community integration after rehabilitation. OBJECTIVE: The study was aimed at exploring and describing the experiences of rehabilitated stroke survivors and perceptions of stakeholders about stroke survivors returning to work in South-West Nigeria...
August 14, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
S E Samaei, A Tirgar, N Khanjani, M Mostafaee, M Bagheri Hosseinabadi
BACKGROUND: Musculoskeletal Disorders (MSDs) are among the most common occupational disorders in many countries and have an increasing trend. OBJECTIVE: The present study was conducted in order to determine the prevalence rate of MSDs in different body regions and the effect of personal factors on the prevalence rate of MSDs among rubber industry workers. METHODS: This analytical and cross-sectional study was performed on 206 workers of an Iranian rubber factory in 2014...
August 14, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
Quan Nha Hong, Marie-France Coutu, Djamal Berbiche
BACKGROUND: The Work Role Functioning Questionnaire (WRFQ) was developed to assess workers' perceived ability to perform job demands and is used to monitor presenteeism. Still few studies on its validity can be found in the literature. OBJECTIVE: The purpose of this study was to assess the items and factorial composition of the Canadian French version of the WRFQ (WRFQ-CF). METHODS: Two measurement approaches were used to test the WRFQ-CF: Classical Test Theory (CTT) and non-parametric Item Response Theory (IRT)...
August 14, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
Ismail El Moudden, Mounir Ouzir, Souad ElBernoussi
BACKGROUND: Speech disorders such as dysphonia and dysarthria represent an early and common manifestation of Parkinson's disease. Class prediction is an essential task in automatic speech treatment, particularly in the Parkinson's disease case. Many classification experiments have been performed which focus on the automatic detection of Parkinson's disease patients from healthy speakers but results are still not optimistic. A major problem in accomplishing this task is high dimensionality of speech data...
August 9, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Aikaterini Oikonomidi, Domilė Tautvydaitė, Mehdi M Gholamrezaee, Hugues Henry, Michael Bacher, Julius Popp
BACKGROUND: Macrophage migration inhibitory factor (MIF) is a pro-inflammatory protein playing a regulatory role in the immune response. First evidence from in vitro and animal studies suggests that MIF may be involved in the development of Alzheimer's disease (AD) pathology. OBJECTIVE: To address in older subjects (i) the relationships between AD pathology and MIF plasma and cerebrospinal fluid (CSF) levels; and (ii) to investigate whether increased MIF-related systemic and CNS inflammation is associated with clinical disease progression...
August 16, 2017: Journal of Alzheimer's Disease: JAD
Sejun Oh, Minhee Kim, Minyoung Lee, Taeyeong Kim, Dongshin Lee, Bumchul Yoon
BACKGROUND: Myofascial trigger points (MTrPs) are related to low back pain and back muscle stiffening, and secondarily to movement impairment. MTrP therapy with an inflatable ball would improve clinical outcomes for chronic non-specific low back pain (CNSLBP) after 6 weeks. OBJECTIVE: The aim of this study was to investigate the effects of MTrPs with an inflatable ball for the elderly with CNSLBP. METHODS: Fifteen elderly patients with chronic non-specific low back pain were evaluated for pain, pressure sensitivity, and physical function at baseline and 1, 3, and 6 weeks of therapy...
August 4, 2017: Journal of Back and Musculoskeletal Rehabilitation
Hong-Wei Wang, Wen-Peng Zhao, Jing Liu, Pan-Pan Tan, Cai Zhang, Bian-Hua Zhou
The present study was conducted to investigate the mechanisms of excessive-fluoride-induced reduction of oocyte development potential in mice. The development morphology of oocyte and the changes of pathomorphology in ovary were observed. The protein expression levels of apoptosis factors, including Bax, Bcl-2, casepase-3, casepase-9 and cytochrome c, and the mRNA expression levels of antioxidant enzymes, including SOD1, GSH-Px1, CAT and inducible nitric oxide synthase were measured by Western blot and real-time PCR, respectively...
August 14, 2017: Chemosphere
Shubo Fang, Qu Cui, Brian Matherne, Aixin Hou
This study initiated an in-situ soil experimental system to quantify the annual dynamics of polychlorinated biphenyl (PCB) congener's concentrations and accumulation rates in soil from atmosphere deposition in a rural-urban fringe, and correlated them by landscape physical and demographic variables in the area. The results showed that the concentrations of all PCB congeners significantly increased with the sampling time (p < 0.05); nearly all the PCB congener concentrations decreased while moving outwards from the urban center...
August 13, 2017: Chemosphere
Violet Oloibiri, Sam De Coninck, Michael Chys, Kristof Demeestere, Stijn W H Van Hulle
The combination of fluorescence excitation-emission matrices (EEM), parallel factor analysis (PARAFAC) and self-organizing maps (SOM) is shown to be a powerful tool in the follow up of dissolved organic matter (DOM) removal from landfill leachate by physical-chemical treatment consisting of coagulation, granular activated carbon (GAC) and ion exchange. Using PARAFAC, three DOM components were identified: C1 representing humic/fulvic-like compounds; C2 representing tryptophan-like compounds; and C3 representing humic-like compounds...
August 11, 2017: Chemosphere
Xiaoling Li, Yongzhen Peng, Baikun Li, Changyong Wu, Liang Zhang, Yaqian Zhao
The effects of two alkali agents, NaOH and Ca(OH)2, on enhancing waste activated sludge (WAS) fermentation and short chain fatty acids (SCFAs) accumulation were studied in semi-continuous stirred tank reactors (semi-CSTR) at different sludge retention time (SRT) (2-10 d). The optimum SRT for SCFAs accumulation of NaOH and Ca(OH)2 adding system was 8 d and 10 d, respectively. Results showed that the average organics yields including soluble chemical oxygen demand (SCOD), protein, and carbohydrate in the NaOH system were as almost twice as that in the Ca(OH)2 system...
August 8, 2017: Chemosphere
Chen Xiao, Zidong Liu, Dapeng Li, Mohamed M Refaey, Rong Tang, Li Li, Xi Zhang
Nitrite has the potential to disturb thyroid hormone homeostasis, but little is known about the underlying mechanisms. In the present study, juvenile grass carp (Ctenopharyngodon idellus) were exposed to various concentrations of nitrite (0, 0.5, 1, 4, and 16 mg/L, respectively). Serum concentrations of triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), 3,3,5'-triiodothyronine (rT3), thyroid-stimulating hormone (TSH), and the activity of iodothyronine deiodinases were assayed at 0, 12, 24, 48, and 96 h after exposure...
August 8, 2017: Chemosphere
Paola Salvati, Olga Petrucci, Mauro Rossi, Cinzia Bianchi, Aurora A Pasqua, Fausto Guzzetti
Floods and landslides are frequent and destructive geo-hydrological hazards that cause harm to people every year. We analysed data on 1292 landslide and 771 flood fatalities that occurred in Italy in the 50-year period 1965-2014, to determine the dependence of the fatalities on gender and age and the circumstances of death by type of hazard. The multinomial probability mass function of the expected fatalities by gender and age, as reported by national census data, were estimated and compared with the observed landslide and flood fatalities...
August 18, 2017: Science of the Total Environment
Yue Zhang, Xuejie Ye, Tianjun Yang, Jinling Li, Long Chen, Wei Zhang, Xuejun Wang
Coal combustion is the most significant anthropogenic mercury emission source in China. In 2013, China signed the Minamata Convention affirming that mercury emissions should be controlled more strictly. Therefore, an evaluation of the costs associated with atmospheric mercury emission reductions from China's coal combustion is essential. In this study, we estimated mercury abatement costs for coal combustion in China for 2010, based on a provincial technology-based mercury emission inventory. In addition, four scenarios were used to project abatement costs for 2020...
August 18, 2017: Science of the Total Environment
John W Redhead, Linda May, Tom H Oliver, Perrine Hamel, Richard Sharp, James M Bullock
A wide variety of tools aim to support decision making by modelling, mapping and quantifying ecosystem services. If decisions are to be properly informed, the accuracy and potential limitations of these tools must be well understood. However, dedicated studies evaluating ecosystem service models against empirical data are rare, especially over large areas. In this paper, we report on the national-scale assessment of a new ecosystem service model for nutrient delivery and retention, the InVEST Nutrient Delivery Ratio model...
August 18, 2017: Science of the Total Environment
Pingting Zhu, Yu Wu, Aihua Yang, Xingsheng Fu, Ming Mao, Zhaoguo Liu
Tumor angiogenesis and inflammation, which play important roles in mediating tumor proliferation and growth, should be inhibited to effectively regulate tumor progression. Catalpol, a main active ingredient extracted from Rehmannia glutinosa, has various pharmacological actions including anti-apoptotic, anti-inflammatory, hypoglycemic and anti-cancer properties. However, the pharmacological effect of catalpol on colon cancer remains largely unknown. The aim of this study was to investigate the effects of catalpol on the proliferation, growth, invasion, tumor angiogenesis and inflammation of CT26 colon cancer in vitro and in vivo...
August 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Wafa Ben Cherif Khedhaier, Ichrak Dridi, Karim Aouam, Mossadok Ben-Attia, Alain Reinberg, Naceur A Boughattas
PURPOSE: This study aims to investigate whether valproic acid (VPA) anticonvulsant activity varied according to circadian dosing-time in mice. METHODS: VPA was administered to mice at four circadian stages (1, 7, 13 and 19h after light onset, (HALO)). The controls received a saline injection followed by a s.c. injection of pentylenetetrazol (PTZ) 30min later. In pretreated animals, VPA was administered 30min before PTZ administration. RESULTS: The results obtained showed that VPA-induced anticonvulsant activity depends on circadian dosing-time in mice...
August 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yuwan Zhao, Zuolei Jing, Jian Lv, Zhiwei Zhang, Jintao Lin, Xuejiao Cao, Zinan Zhao, Pixu Liu, Weifeng Mao
Berberine (BBR) is an isoquinoline alkaloid isolated from Cotridis rhizoma and exhibits multiple biological roles including anti-microbe, anti-inflammation and anti-tumor activities. In this study, two triple-negative breast cancer cell (TNBC) lines, MDA-MB-231 and BT549, were used to investigate the effect of BBR on growth of TNBC in vitro and in vivo. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to evaluate the viability of cells treated with BBR. After 48h treatments, a 50% inhibitory concentration (IC50) of BBR to BT549 and MDA-MB-231 cells are at 16...
August 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Mamilla R Charan Raja, Anand Babu Velappan, Davidraj Chellappan, Joy Debnath, Santanu Kar Mahapatra
Visceral leishmaniasis (VL) is a life threatening infectious disease caused by Leishmania donovani. It leads to the severe immune suppression in the host defense system. Higher cytotoxicity, rigorous side effects and lower therapeutic indexes (TI) of current antileishmanial drugs have created a necessity to develop new molecules with better antileishmanial activity and high TI value. In this study, we have synthesized 36 derivatives of eugenol and screened them for their activity against promastigote and amastigote forms of L...
August 12, 2017: European Journal of Medicinal Chemistry
Jiří Vávra, Miroslav Hyliš, Ivan Fiala, Veronika Sacherová, Charles R Vossbrinck
Structural, molecular and life cycle data are presented for two microsporidian species of the genus Berwaldia: B. singularis Larsson, 1981 (type species of the genus) and B. schaefernai Vávra and Larsson, 1994, parasites of Daphnia pulex Leydig, 1860 and Daphnia galeata Sars, 1863, respectively. Analysis of the SSU rDNA gene confirmed the species status of both species and showed that the GenBank sequence data submitted previously in GenBank for the genus Berwaldia, are from microsporidia that are not Berwaldia...
August 3, 2017: European Journal of Protistology
Roger Sun, Stéphane Champiat, Laurent Dercle, Sandrine Aspeslagh, Eduardo Castanon, Elaine Johanna Limkin, Capucine Baldini, Sophie Postel-Vinay, Antoine Hollebecque, Christophe Massard, Samy Ammari, Eric Deutsch, Jean-Charles Soria, Aurélien Marabelle, Charles Ferté
INTRODUCTION: A number of phase I immunotherapy trials for cancer patients incorporate the absolute lymphocyte count (ALC) as an inclusion criteria. This study aims to assess whether ALC is associated with a lack of response to anti-PD-1/PD-L1 in early clinical trials. METHODS: All consecutive patients treated with anti-PD-1/PD-L1 monotherapy in phase I trials in our institution between December 2011 and January 2014 were reviewed. Baseline ALC, neutrophil-to-lymphocyte ratio (NLR), Royal-Marsden Hospital (RMH) prognostic score, objective response rate (ORR) and disease control rate (DCR = SD + PR + CR, stable disease (SD), partial response (PR), complete response (CR)) defined by Response Evaluation Criteria In Solid Tumours (RECIST) version 1...
August 18, 2017: European Journal of Cancer
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