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nickel toxicity

Xuejing Cui, Bin Wan, Liang-Hong Guo, Yu Yang, Xiao-Min Ren
Co-existence of nanomaterials and environmental pollutants requires in-depth understanding of combined toxicity and underlying mechanism. In this work, we found that co-exposure to the mixture of non-cytotoxic level of single-walled carbon nanotubes (SWCNTs) (10 µg/mL) and Ni2+ (20 µM) induced significant cytotoxicity in macrophages. However, almost equal amount of intracellular Ni2+ was detected after Ni2+/SWCNT co-exposure or Ni2+ single exposure, indicating no enhanced cellular uptake of Ni2+ occurred...
October 17, 2016: Environmental Science & Technology
Imed-Eddine Kadi, Faouzi Dahdouh
Nickel is an abundant carcinogenic and nephrotoxic metal whose activity leads to renal impairment. Previous studies have shown a protective effect of simultaneous vitamin C administration on acute and chronic nickel toxicity. However, very little research relating to the effect of vitamin C pretreatment in preventing nickel-induced acute nephrotoxicity is available. Therefore, the present study aimed to determine the efficiency of vitamin C (VC) pretreatment in preventing acute renal toxicity of nickel. Mice were pretreated orally with vitamin C (16...
September 1, 2016: Arhiv za Higijenu Rada i Toksikologiju
Lu Kong, Xiaojie Gao, Jiaqian Zhu, Ting Zhang, Yuying Xue, Meng Tang
To investigate the reproductive toxicity and underlying mechanism of nickel nanoparticles (Ni NPs), Caenorhabditis elegans (C. elegans) were treated with/without 1.0, 2.5, and 5.0 μg cm(-2) of Ni NPs or nickel microparticles (Ni MPs). Generation time, fertilized egg numbers, spermatide activation and motility were detected. Results indicated, under the same treatment doses, that Ni NPs induced higher reproductive toxicity to C. elegans than Ni MPs. Reproductive toxicities observed in C. elegans included a decrease in brood size, fertilized egg and spermatide activation, but an increase in generation time and out-of-round spermatids...
October 17, 2016: Environmental Toxicology
Leanne Stannard, Shareen H Doak, Ann Doherty, Gareth J Jenkins
Humans are exposed to carcinogens through air, water, food and tobacco smoke. Nickel chloride (NiCl2 ) is a toxic and carcinogenic environmental and occupational pollutant, which was previously classified as a non-genotoxic carcinogen, and thought to not directly alter the DNA. Non-genotoxic carcinogens like NiCl2 are difficult to detect in vitro, hence a heavy reliance on animal studies exists. NiCl2 has previously been classified as a non-genotoxic carcinogen (NGTC); however, after studying the effect of NiCl2 on many mechanistic endpoints, it has become clear that NiCl2 behaves more like a genotoxic carcinogen...
October 17, 2016: Basic & Clinical Pharmacology & Toxicology
R Jiménez-Ballesta, F J García-Navarro, S Bravo, J A Amorós, C Pérez-de-Los-Reyes, M Mejías
Contamination of aquatic systems with potentially toxic trace elements (PTEs) is a major problem throughout the world. The National Park Tablas de Daimiel (NPTD) is considered to make up one of the two most important wetlands in the Biosphere Reserve called "Wet Spot." Since PTEs are good indicator of the prevailing environmental conditions and possible contamination, soil samples collected from 43 sites were analyzed in order to investigate the levels and its distribution of these elements, in the inundated floodplain area of the NPTD wetland...
October 14, 2016: Environmental Geochemistry and Health
Teik Min Chong, Wai-Fong Yin, Jian-Woon Chen, Samuel Mondy, Catherine Grandclément, Denis Faure, Yves Dessaux, Kok-Gan Chan
Trace metals are required in many cellular processes in bacteria but also induce toxic effects to cells when present in excess. As such, various forms of adaptive responses towards extracellular trace metal ions are essential for the survival and fitness of bacteria in their environment. A soil Pseudomonas putida, strain S13.1.2 has been isolated from French vineyard soil samples, and shown to confer resistance to copper ions. Further investigation revealed a high capacity to tolerate elevated concentrations of various heavy metals including nickel, cobalt, cadmium, zinc and arsenic...
December 2016: AMB Express
Ahmet Topal, Muhammed Atamanalp, Ertan Oruç, Hüseyin Serkan Erol
We investigated changes in nuclear factor kappa B (NFkB) activity, antioxidant responses and histopathological effects in the liver, gill and kidney tissues of rainbow trout exposed to nickel chloride (Ni). Two different concentrations (1 mg/L and 2 mg/L) were administrated to fish for 21 days. Tissues were taken from all fish for NFkB activity, histopathological examination and determination of superoxide dismutase (SOD), catalase (CAT) enzyme activity and of lipid peroxidation (LPO), and glutathione (GSH) levels...
January 2017: Chemosphere
Ning Wang, Christopher D Ivey, Christopher G Ingersoll, William G Brumbaugh, David Alvarez, Edward J Hammer, Candice R Bauer, Tom Augspurger, Sandy Raimondo, M Christopher Barnhart
Freshwater mussels, one of the most imperiled groups of animals in the world, are generally under-represented in toxicity databases used for the development of ambient water quality criteria (WQC) and other environmental guidance values. Acute 96-h toxicity tests were conducted to evaluate the sensitivity of 5 species of juvenile mussels from 2 families and 4 tribes to 10 chemicals (ammonia, metals, major ions, and organic compounds), and to "screen" 10 additional chemicals (mainly organic compounds) with a commonly tested mussel species, fatmucket (Lampsilis siliquoidea)...
October 4, 2016: Environmental Toxicology and Chemistry
Deepak Pant, Tenzin Dolker
The research reports a novel green method to use citrus fruits for the management of spent NMC based lithium ion batteries (LIBs). Citrus fruit juice (CJ) can provide an excellent chemical combination to remove the binder and support the leaching with efficiency in between 94% to 100%. CJ have many advantages in LIBs recycling as an economic and green method due to rich in many organic acids like citric and malic acid as complexing agents with ascorbic acid and citrus flavonoids, for the reduction of many heavy metals...
September 30, 2016: Waste Management
Xu Zhen, Wei Cheng Ng, Fendy, Yen Wah Tong, Yanjun Dai, Koon Gee Neoh, Chi-Hwa Wang
In Singapore, approximately 30t/day of carbon-based solid waste are produced from petrochemical processes. This carbon black waste has been shown to possess physical properties that are characteristic of a good adsorbent such as high external surface area. Therefore, there is a growing interest to reutilize and process this carbon black waste into secondary materials such as adsorbents. However, the carbon black waste obtained from petrochemical industries may contain heavy metals that are hazardous to human health and the environment, hence restricting its full potential for re-utilization...
September 20, 2016: Journal of Hazardous Materials
Zafar Iqbal Khan, Kafeel Ahmad, Sumaira Yasmeen, Nudrat Aisha Akram, Muhammad Ashraf, Naunain Mehmood
Metal buildup was estimated in potato (Solanum tuberosum L.), grown in central Punjab, Pakistan. This crop was irrigated with multiple water sources like ground, sewage and canal water. Concentrations of different metals like zinc (Zn), arsenic (As), lead (Pb), iron (Fe), nickel (Ni), molybdenum (Mo), copper (Cu), and selenium (Se) were assessed in the potato crop irrigated with different types of waters. Sewage water treated crop and soil had higher metal concentrations than those treated with other two treatments...
January 2017: Chemosphere
Lucas A R Leite, Natacha H O Pedro, Rodney K de Azevedo, Angela Kinoshita, Roseli F Gennari, Shigueo Watanabe, Vanessa D Abdallah
Pollution in aquatic ecosystems due to negative human activities remains a problem in both freshwater and marine environments and is an ongoing subject of research. Several studies have shown that some fish parasites can be used as a tool for biomonitoring because they demonstrate higher metal accumulation capacity compared to their host tissues. However, compared to acanthocephalans, information regarding the absorption mechanisms and accumulation rates in nematodes is relatively limited. Here, we evaluated the potential of larvae Contracaecum sp...
September 25, 2016: Science of the Total Environment
Manon Gault, Agnès Rodrigue
Ni is recognized as an element that is toxic to humans, acting as an allergen and a carcinogenic agent, and it is also toxic to plants. The toxicity of Ni has been understudied in microorganisms. The data presented here were obtained by submitting the model bacterium Escherichia coli K-12 to nickel stress. To identify expressed genes, RNA-Seq was performed. Bacteria were exposed to 50 µM NiCl2 during 10 min. Exposure to Ni lead to the deregulation of 57% of the E. coli transcripts. Further analysis using DAVID identified most affected biological pathways...
December 2016: Data in Brief
Lucie Dohnalova, Pavel Bucek, Petr Vobornik, Vlastimil Dohnal
Nickel is a metal that can be present in products containing hardened edible oils, possibly as leftover catalyst from the vegetable oil hardening process. Nickel may cause toxic effects including the promotion of cancer and contact allergy. In this work, nickel content was determined in hydrogenated vegetable fats and confectionery products, made with these fats, available on the Czech market using newly developed method combining microwave digestion and graphite furnace AAS. While concentrations of 0.086±0...
February 15, 2017: Food Chemistry
Barbara Zambelli, Vladimir N Uversky, Stefano Ciurli
The interplay of the presence of nickel and protein disorder in processes affecting human health is the focus of the present review. Many systems involving nickel as either a cofactor or as a toxic contaminant are characterized by large disorder. The role of nickel in the biochemistry of bacterial enzymes is discussed here, covering both the beneficial effects of nickel in the human microbiota as well as the role of nickel-depending bacteria in human pathogenesis. In addition, the hazardous health effects caused by nickel exposure to humans, namely nickel-induced carcinogenesis and allergy, are triggered by non-specific interactions of nickel with macromolecules and formation of reactive compounds that mediate cellular damage...
September 17, 2016: Biochimica et Biophysica Acta
Christian E Schlekat, Emily R Garman, Marnix Lu Vangheluwe, G Allen Burton
To assess nickel (Ni) toxicity and behavior in freshwater sediments, a large-scale laboratory and field sediment testing program was conducted. The program used an integrative testing strategy to generate scientifically based threshold values for Ni in sediments and to develop integrated equilibrium partitioning-based bioavailability models for assessing risks of Ni to benthic ecosystems. The sediment testing program was a multi-institutional collaboration that involved extensive laboratory testing, field validation of laboratory findings, characterization of Ni behavior in natural and laboratory conditions, and examination of solid phase Ni speciation in sediments...
October 2016: Integrated Environmental Assessment and Management
David M Costello, Chad R Hammerschmidt, G Allen Burton
Metals in sediment can be complexed by minerals, partition between solid and aqueous phases, and cause toxicity at high concentrations. We studied how the oxidation of surface sediment that occurs during aging alters the partitioning and toxicity of Ni. Two sediments (Burntwood and Raisin) were amended with Ni, equilibrated, incubated in a flow-through flume, and examined for sediment physicochemistry and toxicity to Hyalella azteca (7 day growth). Through time, the sediment surface (5 mm) was oxidized, acid-volatile sulfide concentrations declined in Raisin sediment, and amorphous Fe oxides increased...
October 18, 2016: Environmental Science & Technology
Yue Ge, Maribel Bruno, Najwa Haykal-Coates, Kathleen Wallace, Debora Andrews, Adam Swank, Witold Winnik, Jeffrey A Ross
Understanding the mechanisms underlying toxicity initiated by nickel, a ubiquitous environmental contaminant and known human carcinogen is necessary for proper assessment of its risks to human and environment. Among a variety of toxic mechanisms, disruption of protein responses and protein response-based biochemical pathways represents a key mechanism through which nickel induces cytotoxicity and carcinogenesis. To identify protein responses and biochemical pathways that are critical to nickel-induced toxicity responses, we measured cytotoxicity and changes in expression and phosphorylation status of 14 critical biochemical pathway regulators in human BEAS-2B cells exposed to four concentrations of nickel using an integrated proteomic approach...
2016: PloS One
Francesca Gissi, Jennifer L Stauber, Monique T Binet, Lisa A Golding, Merrin S Adams, Christian E Schlekat, Emily R Garman, Dianne F Jolley
The South East Asian Melanesian (SEAM) region contains the world's largest deposits of nickel lateritic ores. Environmental impacts may occur if mining operations are not adequately managed. Effects data for tropical ecosystems are required to assess risks of contaminant exposure and to derive water quality guidelines (WQG) to manage these risks. Currently, risk assessment tools and WQGs for the tropics are limited due to the sparse research on how contaminants impact tropical biota. As part of a larger project to develop appropriate risk assessment tools to ensure sustainable nickel production in SEAM, nickel effects data were required...
November 2016: Environmental Pollution
Masashi Kato, Mohammad Daud Azimi, Said Hafizullah Fayaz, Muhammad Dawood Shah, Md Zahirul Hoque, Nobuyuki Hamajima, Shoko Ohnuma, Tomomi Ohtsuka, Masao Maeda, Masafumi Yoshinaga
Toxic elements in drinking water have great effects on human health. However, there is very limited information about toxic elements in drinking water in Afghanistan. In this study, levels of 10 elements (chromium, nickel, copper, arsenic, cadmium, antimony, barium, mercury, lead and uranium) in 227 well drinking water samples in Kabul, Afghanistan were examined for the first time. Chromium (in 0.9% of the 227 samples), arsenic (7.0%) and uranium (19.4%) exceeded the values in WHO health-based guidelines for drinking-water quality...
December 2016: Chemosphere
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