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nickel toxicity

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https://www.readbyqxmd.com/read/29471240/a-multiregional-survey-of-nickel-in-outdoor-air-particulate-matter-in-china-implication-for-human-exposure
#1
Han Li, Yanjian Wan, Xiao Chen, Lu Cheng, Xueyu Yang, Wei Xia, Shunqing Xu, Hongling Zhang
Nickel is a widespread environmental contaminant, and it is toxic to humans in certain forms at high doses. Despite this, nationwide data on nickel in outdoor air particulate matter and human exposure to nickel through inhalation in China are limited. In the present study, 662 outdoor air samples from seven representative provinces such as Shanghai, Hubei, Hunan, Hebei, Guangdong, Yunnan, and Shanxi were collected between March 2013 and February 2014 and analyzed by inductively coupled plasma mass spectrometry...
February 19, 2018: Chemosphere
https://www.readbyqxmd.com/read/29459162/enrichment-spatial-distribution-of-potential-ecological-and-human-health-risk-assessment-via-toxic-metals-in-soil-and-surface-water-ingestion-in-the-vicinity-of-sewakht-mines-district-chitral-northern-pakistan
#2
Inayat Ur Rehman, Muhammad Ishaq, Liaqat Ali, Sardar Khan, Imtiaz Ahmad, Imran Ud Din, Hameed Ullah
This study focuses on enrichment, spatial distribution, potential ecological risk index (PERI) and human health risk of various toxic metals taken via soil and surface water in the vicinity of Sewakht mines, Pakistan. The samples of soils (n = 54) of different fields and surface water (n = 38) were analyzed for toxic metals including cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), manganese (Mn), lead (Pb), nickel (Ni), zinc (Zn) and molybdenum (Mo). Soil pollution level was evaluated using pollution indices including geo-accumulation index (Igeo), contamination factor (CF), degree of contamination (CD), enrichment factor (EF) and PERI...
February 16, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29456201/modular-radical-cross-coupling-with-sulfones-enables-access-to-sp-3-rich-fluoro-alkylated-scaffolds
#3
Rohan R Merchant, Jacob T Edwards, Tian Qin, Monika M Kruszyk, Cheng Bi, Guanda Che, Deng-Hui Bao, Wenhua Qiao, Lijie Sun, Michael R Collins, Olugbeminiyi O Fadeyi, Gary M Gallego, James J Mousseau, Philippe Nuhant, Phil S Baran
Cross-coupling chemistry is widely applied to carbon-carbon bond formation in the synthesis of medicines, agrochemicals, and other functional materials. Recently single-electron-induced variants of this reaction class have proven particularly useful in the formation of C(sp2 )-C(sp3 ) linkages, though certain compound classes have remained a challenge. Here we report the use of sulfones to activate the alkyl coupling partner in nickel-catalyzed radical cross-coupling with aryl zinc reagents. This method's tolerance of fluoroalkyl substituents proved particularly advantageous for the streamlined preparation of pharmaceutically-oriented fluorinated scaffolds that previously required multiple steps, toxic reagents, and non-modular retrosynthetic blueprints...
February 18, 2018: Science
https://www.readbyqxmd.com/read/29453538/nickel-oxide-nanoparticles-induced-transcriptomic-alterations-in-hepg2-cells
#4
Quaiser Saquib, Maqsood A Siddiqui, Javed Ahmad, Sabiha M Ansari, Mohammad Faisal, Rizwan Wahab, Abdulrahman A Alatar, Abdulaziz A Al-Khedhairy, Javed Musarrat
Nickel oxide nanoparticles (NiO-NPs) are increasingly used and concerns have been raised on its toxicity. Although a few studies have reported the toxicity of NiO-NPs, a comprehensive understanding of NiO-NPs toxicity in human cells is still lagging. In this study, we integrated transcriptomic approach and genotoxic evidence to depict the mechanism of NiO-NPs toxicity in human hepatocellular carcinoma (HepG2) cells. DNA damage analysis was done using comet assay, which showed 26-fold greater tail moment in HepG2 cells at the highest concentration of 100 μg/ml...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29447378/trace-metal-metabolism-in-plants
#5
Elisa Andresen, Edgar Peiter, Hendrik Küpper
Many trace metals are essential micronutrients, but also potent toxins. Due to natural and anthropogenic causes, vastly different trace metal concentrations occur in various habitats, ranging from deficient to toxic levels. Therefore, one focus of plant research is on the response to trace metals in terms of uptake, transport, sequestration, speciation, physiological use, deficiency, toxicity, and detoxification. In this review, we cover most of these aspects for the essential micronutrients copper, iron, manganese, molybdenum, nickel, and zinc to provide a broader overview than found in other recent reviews, to cross-link aspects of knowledge in this very active research field that are often seen in a separated way...
February 13, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29437544/applicability-of-an-in-vitro-gastrointestinal-digestion-method-to-evaluation-of-toxic-elements-bioaccessibility-from-algae-for-human-consumption
#6
Donatella Desideri, Carla Roselli, Laura Feduzi, Lucia Ugolini, Maria Assunta Meli
This study aimed to investigate the bioaccessibility of toxic elements, including aluminum (Al), arsenic (As), nickel (Ni), cadmium (Cd), and lead (Pb) in five commercial algae consumed by humans in Italy. The degree of bioaccessibility of these elements may have important implications for human health. Simulation of gastrointestinal tract (GIT) digestion was divided into three stages through use of synthetic saliva, gastric, and bile-pancreas solutions. After pre-treatment with a saliva solution, seaweed samples underwent one of the following treatments: (1) simulated gastric digestion only or (2) simulated complete GIT digestion (gastric digestion followed by bile-pancreas digestion)...
February 13, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29427928/facile-synthesis-of-hierarchical-nickel-iii-oxide-nanostructure-a-synergistic-remediating-action-towards-water-contaminants
#7
Sayan Dey, Soumik Podder, A Roychowdhury, Dipankar Das, Chandan Kr Ghosh
Heavy metal ion removal from consumable water is an indispensable need to maintain healthy life. Therefore cost effective and highly efficient sorbents are strongly needed to pose threat to real water pollution. Nanomaterials are widely used to maintain clean aqueous system in a very cost effective way with high removal efficiency. In this present work, pure coral like Ni2O3 nanostructures were prescribed for Cr(VI) remediation which were prepared by two step synthesis procedure at room temperature. The single hierarchical morphology as confirmed from HRTEM (size∼200 nm) were subjected to toxic Cr(VI) ion removal experiments...
February 7, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29423633/nickel-oxide-nio-nanoparticles-disturb-physiology-and-induce-cell-death-in-the-yeast-saccharomyces-cerevisiae
#8
Cátia A Sousa, Helena M V M Soares, Eduardo V Soares
The increasing use of nanoparticles (NPs) has spurred concerns about their toxic effects. This work aimed to assess the potential hazards of nickel oxide (NiO) NPs using the yeast Saccharomyces cerevisiae as a cell model. Yeast cells exposed for 6 h to 100 mg/L NiO NPs presented reduced metabolic activity (esterase activity and FUN-1 dye processing) and enhanced accumulation of reactive oxygen species. NiO NPs induced the loss of cell viability in a dose-dependent manner. Study of the dissolution of NiO NPs in aqueous media, together with the toxicological data, suggests that the nickel released by the NPs cannot explain all the toxic effects observed in S...
February 8, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29423230/review-of-carcinogenicity-of-hexavalent-chrome-and-proposal-of-revising-approval-standards-for-an-occupational-cancers-in-korea
#9
Jungwon Kim, Sangyun Seo, Yangho Kim, Dae Hwan Kim
Background: The objective of this study is to suggest revised recognition standards for occupational disease due to chromium (VI) by reflecting recent domestic and international research works and considering domestic exposure status with respect to target organs, exposure period, and cumulative exposure dose in relation to the chromium (VI)-induced occupational disease compensation. Methods: In this study, the reports published by major international institutions such as World Health Organization (WHO) International Agency for Research on Cancer (IARC) (2012), Occupational Safety and Health Administration (OSHA) (2006), National Institute for Occupational Safety and Health (NIOSH) (2013), American Conference of Governmental Industrial Hygienists (ACGIH) (2004), National Toxicology Program (NTP) (2014), and Agency for Toxic Substances and Disease Registry (ASTDR) (2012) were reviewed and the recent research works searched by PubMed were summarized...
2018: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29420949/nickel-mediated-allosteric-manipulation-of-g-quadruplex-dnazyme-for-highly-selective-detection-of-histidine
#10
Zijun Li, Jian Zhao, Zhaoyin Wang, Zhihui Dai
Since abnormal metabolism of histidine (His) is defined as an indicator of several diseases, detection of His in biological fluids becomes increasingly urgent to us. However, due to similar structures and properties of different amino acids, selective quantification of His is difficulty, and typically needs the participation of special reagents. In this work, we report for the first time that nickel ions (Ni2+) can induce the allostery of G-quadruplex, and is thus able to manipulate the activity of G-quadruplex DNAzyme...
May 30, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29417696/structure-and-function-of-the-bacillithiol-s-transferase-bsta-from-staphylococcus-aureus
#11
Joel W Francis, Christopher J Royer, Paul D Cook
Bacillithiol is a low-molecular weight thiol produced by many gram-positive organisms, including Staphylococcus aureus and Bacillus anthracis. It is the major thiol responsible for maintaining redox homeostasis and cellular detoxification, including inactivation of the antibiotic fosfomycin. The metal-dependent bacillithiol transferase BstA is likely involved in these sorts of detoxification processes, but the exact substrates and enzyme mechanism have not been identified. Here we report the 1.34 Å resolution X-ray crystallographic structure of BstA from S...
February 8, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29413098/status-and-interrelationship-of-toenail-elements-in-pacific-children
#12
Shamshad Karatela, Neil I Ward, Irene Suilan Zeng, Janis Paterson
OBJECTIVE: Elemental deficiencies or in excess effects growth and development. Pacific population are at a disadvantage due to food insecurity as compared to New Zealand European households. This study aims to evaluate the status and interrelationship of elements (essential, non-essential and toxic) in nine-year-old Pacific children who were part of the Pacific Island Families Study living in New Zealand. MATERIALS AND METHODS: This observational study included 278 eligible nine-year-old children...
March 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29391828/toxic-elements-as-biomarkers-for-breast-cancer-a-meta-analysis-study
#13
REVIEW
Leila Jouybari, Marzieh Saei Ghare Naz, Akram Sanagoo, Faezeh Kiani, Fatemeh Sayehmiri, Kourosh Sayehmiri, Ali Hasanpour Dehkordi
Aims and background: Breast cancer (BC) is responsible for a large proportion of incidence of cancer in the world. Identifying the risk factors contributing to the incidence of BC is crucial to find efficient preventive and management strategies for this disease. Several studies have examined Arsenic (As), Cadmium (Cd), and Nickel (Ni) as risk factors for BC. The present study aimed at studying the link between As, Cd, and Ni concentrations and BC by using a meta-analysis. Materials and methods: All case-control studies addressing the relationship between As, Cd, and Ni concentrations with BC were identified through electronic search databases (Scopus, ISI Web of Science, PubMed, EmBase, and Cochrane Library)...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29379996/toxicity-of-nickel-on-the-selected-species-of-marine-diatoms-and-copepods
#14
Karthikeyan Panneerselvam, Shambanagouda Rudragouda Marigoudar, Mohan Dhandapani
Toxicity values for nickel on marine diatoms and copepods were derived based on bioassay tests. The 96 h IC50 of nickel on diatoms, Odontella mobiliensis and Coscinodiscus centralis were 0.31 ± 0.01 and 0.62 ± 0.02 mg/L and LC50 values on copepods, Oithona similis and Acartia danae were 2.78 ± 0.14 and 2.34 ± 0.32 mg/L, respectively. The species mean chronic values of nickel were 0.016, 0.17, 0.57 and 0.42 mg/L for O. mobiliensis, C. centralis, O. similis and A. danae, respectively...
January 29, 2018: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29365163/extra-articular-retained-missiles-is-surveillance-of-lead-levels-needed
#15
Walter N Nickel, Theodore J Steelman, Zena R Sabath, Benjamin K Potter
Background: Although gunshot wounds are relatively common, lead toxicity associated with extra-articular retained missiles (EARMs) is an uncommon, yet potentially devastating, complication. Although the risk of lead toxicity with intra-articular retained missiles is well known, EARMs are routinely left in situ or only removed in selected circumstances secondary to the relatively rare occurrence of complications. Methods: We first describe a patient with systemic lead poisoning associated with retained lead fragments after a gunshot-induced left femoral shaft fracture...
January 22, 2018: Military Medicine
https://www.readbyqxmd.com/read/29351606/analysis-of-metal-tolerance-in-rhizobium-leguminosarum-strains-isolated-from-an-ultramafic-soil
#16
Laura Rubio-Sanz, Belén Brito, Jose Palacios
Natural habitats containing high amounts of heavy metals provide a valuable source of bacteria adapted to deal with metal toxicity. A functional analysis of the population of legume endosymbiotic bacteria in an ultramafic soil was undertaken by studying a collection of Rhizobium leguminosarum bv viciae (Rlv) isolates obtained using pea as trap plant. One of the isolates, Rlv UPM1137, was selected on the basis of its higher tolerance to nickel and cobalt and presence of inducible mechanisms for such tolerance...
January 17, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29331719/regulated-effects-of-prorocentrum-donghaiense-lu-exudate-on-nickel-bioavailability-when-cultured-with-different-nitrogen-sources
#17
Xu-Guang Huang, Shun-Xing Li, Feng-Jiao Liu, Wang-Rong Lan
Exudates by marine phytoplankton and metals coexist in the seawater, but little is known about their interaction. In this study, cultures of Prorocentrum donghaiense Lu were grown in urea and ammonium, and then exposed to different Ni ion levels in order to study the effects of Ni ions on algal growth. The regulatory mechanisms of P. donghaiense Lu for coping with different Ni ion levels was investigating by characterizing dissolved organic carbon (DOC), carbohydrate and protein content released per cell, hydropathy properties (hydrophilic and hydrophobic fractions) and thiol compounds (cysteine-like or glutathione-like)...
January 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29324691/physiological-and-comparative-genomic-analysis-of-arthrobacter-sp-srs-w-1-2016-provides-insights-on-niche-adaptation-for-survival-in-uraniferous-soils
#18
Ashvini Chauhan, Ashish Pathak, Rajneesh Jaswal, Bobby Edwards Iii, Demario Chappell, Christopher Ball, Reyna Garcia-Sillas, Paul Stothard, John Seaman
Arthrobacter sp. strain SRS-W-1-2016 was isolated on high concentrations of uranium (U) from the Savannah River Site (SRS) that remains co-contaminated by radionuclides, heavy metals, and organics. SRS is located on the northeast bank of the Savannah River (South Carolina, USA), which is a U.S. Department of Energy (DOE) managed ecosystem left historically contaminated from decades of nuclear weapons production activities. Predominant contaminants within the impacted SRS environment include U and Nickel (Ni), both of which can be transformed microbially into less toxic forms via metal complexation mechanisms...
January 11, 2018: Genes
https://www.readbyqxmd.com/read/29321978/toxicity-of-formulants-and-heavy-metals-in-glyphosate-based-herbicides-and-other-pesticides
#19
N Defarge, J Spiroux de Vendômois, G E Séralini
The major pesticides of the world are glyphosate-based herbicides (GBH), and their toxicity is highly debated. To understand their mode of action, the comparative herbicidal and toxicological effects of glyphosate (G) alone and 14 of its formulations were studied in this work, as a model for pesticides. GBH are mixtures of water, with commonly 36-48% G claimed as the active principle. As with other pesticides, 10-20% of GBH consist of chemical formulants. We previously identified these by mass spectrometry and found them to be mainly families of petroleum-based oxidized molecules, such as POEA, and other contaminants...
2018: Toxicology Reports
https://www.readbyqxmd.com/read/29320235/a-limited-survey-of-metal-content-in-blue-jack-mackerel-trachurus-picturatus-obtained-from-markets-in-the-canary-islands
#20
Carmen Rubio, Laura Acosta, Gara Luis-González, Dailos González-Weller, Consuelo Revert, Arturo Hardisson, Ángel Gutiérrez
The levels of 20 metals (aluminum, boron, barium, calcium, cadmium, cobalt, chromium, copper, iron, potassium, lithium, magnesium, manganese, molybdenum, sodium, nickel, lead, strontium, vanadium, and zinc) were analyzed in muscle and liver tissue of Trachurus picturatus marketed in the Canary Islands (Spain) by using inductively coupled plasma optical emission spectrometry. In the liver samples, the mean concentrations in milligrams per kilogram wet weight (wt) of Al (14.7), B (0.99), Ba (1.64), Ca (314), Cd (2...
January 10, 2018: Journal of Food Protection
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