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https://www.readbyqxmd.com/read/28822516/comparison-of-yoga-and-walking-exercise-on-cardiac-time-intervals-as-a-measure-of-cardiac-function-in-elderly-with-increased-pulse-pressure
#1
Satish Gurunathrao Patil, Shankargouda S Patil, Manjunatha R Aithala, Kusal Kanti Das
OBJECTIVE: Arterial aging along with increased blood pressure(BP) has become the major cardiovascular(CV) risk in elderly. The aim of the study was to compare the effects of yoga program and walking-exercise on cardiac function in elderly with increased pulse pressure (PP). METHODS: An open label, parallel-group randomized controlled study design was adopted. Elderly individuals aged ≥60 years with PP≥60mmHg were recruited for the study. Yoga (study) group (n=30) was assigned for yoga training and walking (exercise) group (n=30) for walking with loosening practices for one hour in the morning for 6days in a week for 3 months...
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28813291/an-ecological-model-of-mediators-of-change-in-couple-relationship-education
#2
REVIEW
W Kim Halford, Christopher A Pepping
Couple Relationship Education (RE) seeks to enrich couples' relationships, and assist them to manage stressful life events [1]. In the current paper we present an ecological model of couple relationships intended to guide the practice of RE, analyze the mediators of RE effects, and suggest future research needs to assess moderators and mediators of RE effects in order to enhance the impact of RE.
February 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28813188/cannabis-related-problems-and-social-anxiety-the-mediational-role-of-post-event-processing
#3
Anthony H Ecker, Julia D Buckner
BACKGROUND: Cannabis is the most commonly used illicit drug in the US, and is associated with a range of psychological, social, and physical health-related problems. Individuals who endorse elevated levels of social anxiety are especially at risk for experiencing cannabis-related problems, including cannabis use disorder, despite not using cannabis more often than those with more normative social anxiety. Identification of mechanisms that underlie the relationship between social anxiety and cannabis-related problems may inform treatment and prevention efforts...
August 16, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28806429/current-concepts-of-bruxism
#4
Daniele Manfredini, Junia Serra-Negra, Fabio Carboncini, Frank Lobbezoo
Bruxism is a common phenomenon, and emerging evidence suggests that biologic, psychologic, and exogenous factors have greater involvement than morphologic factors in its etiology. Diagnosis should adopt the grading system of possible, probable, and definite. In children, it could be a warning sign of certain psychologic disorders. The proposed mechanism for the bruxism-pain relationship at the individual level is that stress sensitivity and anxious personality traits may be responsible for bruxism activities that may lead to temporomandibular pain, which in turn is modulated by psychosocial factors...
August 14, 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/28801243/peroxiredoxin-2-plays-a-pivotal-role-as-multimodal-cytoprotector-in-the-early-phase-of-pulmonary-hypertension
#5
Enrica Federti, Alessandro Matte', Alessandra Ghigo, Immacolata Andolfo, Cimino James, Angela Siciliano, Christophe Leboeuf, Anne Janin, Francesco Manna, Soo Young Choi, Achille Iolascon, Elisabetta Beneduce, Davide Melisi, Dae Won Kim, Sonia Levi, Lucia De Franceschi
Pulmonary-artery-hypertension (PAH) is a life-threatening and highly invalidating chronic disorder. Chronic oxidation contributes to lung damage and disease progression. Peroxiredoxin-2 (Prx2) is a typical 2-cysteine (Cys) peroxiredoxin but its role on lung homestasis is yet to be fully defined. Here, we showed that Prx2(-/-) mice displayed chronic lung inflammatory disease associated with (i) abnormal pulmonary vascular dysfunction; and (ii) increased markers of extracellular-matrix remodeling. Hypoxia was used to induce PAH...
August 8, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28793778/peroxiredoxin-2-a-novel-regulator-of-iron-homeostasis-in-ineffective-erythropoiesis
#6
Alessandro Matte, Luigia De Falco, Enrica Federti, Anna Cozzi, Achille Iolascon, Sonia Levi, Narla Mohandas, Alberto Zamo, Mariasole Bruno, Christophe Leboeuf, Anne Janin, Angela Siciliano, Thomas Ganz, Giorgia Federico, Francesca Carlomagno, Sebastian Mueller, Ines Silva, Carmine Carbone, Davide Melisi, D W Kim, Soo Young Choi, Lucia DE Franceschi
AIMS: Iron-overload (IO) is a life-threatening complication of chronic hemolytic disorders such as β-thalassemia. IO results in severe cellular oxidative damage, leading to organ failure. Peroxiredoxin-2 (Prx2), a typical 2-cysteine-(Cys)-peroxiredoxin, is an important component of cyto-protective system, but its response to IO is still to be fully defined. RESULTS: We studied the effects of IO on Prx2-knockout mice (Prx2-/-). The absence of Prx2 enhanced toxicity due to IO on erythropoiesis...
August 10, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28790976/factors-affecting-measurement-of-salivary-cortisol-and-secretory-immunoglobulin-a-in-field-studies-of-athletes
#7
Barry Thomas Pritchard, Warren Stanton, Roger Lord, Peter Petocz, Gert-Jan Pepping
AIMS: Biological and lifestyle factors, such as daily rhythm, caffeine ingestion, recent infection, and antibiotic intake, have been shown to influence measurements of salivary cortisol (SC) and secretory immunoglobulin A (sIgA). Current methodology in unsynchronized, field-based biomarker studies does not take these effects into account. Moreover, very little is known about the combined effects of biological and lifestyle factors on SC and sIgA. This study supports development of a protocol for measuring biomarkers from saliva collected in field studies by examining the individual and combined effects of these factors on SC and sIgA...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28790847/combined-detection-of-dickkopf-1-subtype-classification-autoantibodies-as-biomarkers-for-the-diagnosis-and-prognosis-of-non-small-cell-lung-cancer
#8
Lei Shen, Xiaoguang Wu, Jinjing Tan, Meng Gu, Yu Teng, Zitong Wang, Wentao Yue
PURPOSE: This study aims to identify the clinical significance of serum autoantibodies against dickkopf-1 (DKK1) and evaluate their feasibility in the immunodiagnosis and prognosis of non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN: Epitope mapping by peptide microarray-based serum screening of NSCLC patients (n=72) and healthy controls (n=16) was performed. Indirect ELISA with peptides was used to measure the serum levels of autoantibodies in 206 NSCLC patients and 99 healthy controls...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28782091/infant-parasympathetic-and-sympathetic-activity-during-baseline-stress-and-recovery-interactions-with-prenatal-adversity-predict-physical-aggression-in-toddlerhood
#9
J Suurland, K B van der Heijden, S C J Huijbregts, S H M van Goozen, H Swaab
Exposure to prenatal adversity is associated with aggression later in life. Individual differences in autonomic nervous system (ANS) functioning, specifically nonreciprocal activation of the parasympathetic (PNS) and sympathetic (SNS) nervous systems, increase susceptibility to aggression, especially in the context of adversity. Previous work examining interactions between early adversity and ANS functioning in infancy is scarce and has not examined interaction between PNS and SNS. This study examined whether the PNS and SNS moderate the relation between cumulative prenatal risk and early physical aggression in 124 children (57% male)...
August 7, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28781960/dimerization-facilitates-the-conformational-transitions-for-bacterial-phosphotransferase-enzyme-i-autophosphorylation-in-an-allosteric-manner
#10
Ko On Lee, Young-Joo Yun, Iktae Kim, Jeong-Yong Suh
The bacterial phosphotransferase system is central to sugar uptake and phosphorylation. Enzyme I (EI), the first enzyme of the system, autophosphorylates as a dimer using phosphoenolpyruvate (PEP), but it is not clearly understood how dimerization activates the enzyme activity. Here, we show that EI dimerization is important for proper conformational transitions and the domain association required for the autophosphorylation. EI(G356S) with reduced dimerization affinity and lower autophosphorylation activity revealed that significantly hindered conformational transitions are required for the phosphoryl transfer reaction...
August 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28775288/a-polypeptide-from-the-junction-region-sequence-of-ews-fli1-inhibits-ewing-s-sarcoma-cells-interacts-with-the-ews-fli1-and-partner-proteins
#11
Krishna Priya Thangaretnam, Gopal Gopisetty, Priya Ramanathan, Thangarajan Rajkumar
The EWS-FLI1 chimeric protein uniquely expressed in Ewing's sarcoma has an obligate role in its aetiology. In our previous report we showed that ectopic expression of the DNA sequences form the junction region (a.a 251-280) can inhibit Ewing's sarcoma cell growth. In the present report, we introduced a peptide (TAT/NLS/EWS-PEP) comprising of thirty amino acids spanning the junction in conjunction with HIV-1-trans-activating (TAT) and nuclear localization signal sequence (NLS). Peptide uptake and localization studies revealed presence of peptide in ~99% of transduced cells and in the nucleus...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28774803/temporal-stability-and-drivers-of-change-in-cardiac-autonomic-nervous-system-activity
#12
Mandy X Hu, Femke Lamers, Brenda W J H Penninx, Eco J C de Geus
OBJECTIVES: This study determined temporal stability of ambulatory measured cardiac autonomic activity for different time periods and investigated potential drivers of changes in this activity. METHODS: Data was drawn from baseline (n=2379), 2-year (n=2245), and 6-year (n=1876) follow-up from the Netherlands Study of Depression and Anxiety. Cardiac autonomic activity was measured with heart rate (HR), respiratory sinus arrhythmia (RSA) and pre-ejection period (PEP)...
July 27, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28774566/correlation-between-anthrax-lethal-toxin-neutralizing-antibody-levels-and-survival-in-guinea-pigs-and-nonhuman-primates-vaccinated-with-the-av7909-anthrax-vaccine-candidate
#13
Vladimir Savransky, Jeffry D Shearer, Melicia R Gainey, Daniel C Sanford, Gloria S Sivko, Gregory V Stark, Na Li, Boris Ionin, Michael J Lacy, Mario H Skiadopoulos
The anthrax vaccine candidate AV7909 is being developed as a next generation vaccine for a post-exposure prophylaxis (PEP) indication against anthrax. AV7909 consists of the Anthrax Vaccine Adsorbed (AVA, BioThrax®) bulk drug substance adjuvanted with the immunostimulatory oligodeoxynucleotide (ODN) compound, CPG 7909. The addition of CPG 7909 to AVA enhances both the magnitude and the kinetics of antibody responses in animals and human subjects, making AV7909 a suitable next-generation vaccine for use in a PEP setting...
July 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28771483/myeloid-specific-deletion-of-nox2-prevents-the-metabolic-and-neurologic-consequences-of-high-fat-diet
#14
Jennifer K Pepping, Bolormaa Vandanmagsar, Sun-Ok Fernandez-Kim, Jingying Zhang, Randall L Mynatt, Annadora J Bruce-Keller
High fat diet-induced obesity is associated with inflammatory and oxidative signaling in macrophages that likely participates in metabolic and physiologic impairment. One key factor that could drive pathologic changes in macrophages is the pro-inflammatory, pro-oxidant enzyme NADPH oxidase. However, NADPH oxidase is a pleiotropic enzyme with both pathologic and physiologic functions, ruling out indiscriminant NADPH oxidase inhibition as a viable therapy. To determine if targeted inhibition of monocyte/macrophage NADPH oxidase could mitigate obesity pathology, we generated mice that lack the NADPH oxidase catalytic subunit NOX2 in myeloid lineage cells...
2017: PloS One
https://www.readbyqxmd.com/read/28760263/time-series-analysis-and-mortality-model-of-dog-bite-victims-presented-for-treatment-at-a-referral-clinic-for-rabies-exposure-in-monrovia-liberia-2010-2013
#15
Ayodeji O Olarinmoye, Johnson F Ojo, Ayotunde J Fasunla, Olayinka O Ishola, Fahnboah G Dakinah, Charles K Mulbah, Khalid Al-Hezaimi, Babasola O Olugasa
We developed time trend model, determined treatment outcome and estimated annual human deaths among dog bite victims (DBVs) from 2010 to 2013 in Monrovia, Liberia. Data obtained from clinic records included victim's age, gender and site of bite marks, site name of residence of rabies-exposed patients, promptness of care sought, initial treatment and post-exposure-prophylaxis (PEP) compliance. We computed DBV time-trend plot, seasonal index and year 2014 case forecast. Associated annual human death (AHD) was estimated using a standardized decision tree model...
August 2017: Spatial and Spatio-temporal Epidemiology
https://www.readbyqxmd.com/read/28760196/effects-of-pep-1-fk506bp-on-cyst-formation-in-polycystic-kidney-disease
#16
Hyo Sang Jo, Won Sik Eum, Eun Young Park, Je Young Ko, Do Yeon Kim, Dae Won Kim, Min Jea Shin, Ora Son, Su Bin Cho, Jung Hwan Park, Chi Hern Lee, Eun Ji Yeo, Hyeon Ji Yeo, Yeon Joo Choi, Jong Kyu Youn, Sung-Woo Cho, Jinseu Park, Jong Hoon Park, Soo Young Choi
Polycystic kidney disease (PKD) is one of the most common inherited disorders, whereby progressive cyst formation in the kidney leads to renal failure. FK506 binding protein 12 (FK506BP) is an immunophilin protein which performs multiple functions including regulation of cell signaling and survival. In this study, we determined the roles of PEP-1-FK506BP on cell proliferation and cyst formation in PKD cells. Purified PEP-1-FK506BP transduced into PKD cells and markedly inhibited cell proliferation. Also, PEP-1-FK506BP drastically inhibited the expression levels of p-Akt, p-p70S6K, p-mTOR, and p-ERK in PKD cells...
July 28, 2017: BMB Reports
https://www.readbyqxmd.com/read/28753003/site-of-tagging-influences-the-ochratoxin-recognition-by-peptide-nfo4-a-molecular-dynamics-study
#17
Aby A Thyparambil, Tigran M Abramyan, Ingrid Bazin, Anthony Guiseppi-Elie
Molecular recognition by synthetic peptides is growing in importance in the design of biosensing elements used in the detection and monitoring of a wide variety of hapten bioanlaytes. Conferring specificity via bioimmobilization and subsequent recovery and purification of such sensing elements are aided by the use of affinity tags. However, the tag and its site of placement can potentially compromise the hapten recognition capabilities of the peptide, necessitating a detailed experimental characterization and optimization of the tagged molecular recognition entity...
August 16, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28751898/comparative-analysis-of-chloroplast-psbd-promoters-in-terrestrial-plants
#18
Shuichi Shimmura, Mikio Nozoe, Shota Kitora, Satoko Kin, Shigeru Matsutani, Yoko Ishizaki, Yoichi Nakahira, Takashi Shiina
The transcription of photosynthesis genes encoded by the plastid genome is mainly mediated by a prokaryotic-type RNA polymerase called plastid-encoded plastid RNA polymerase (PEP). Standard PEP-dependent promoters resemble bacterial sigma-70-type promoters containing the so-called -10 and -35 elements. On the other hand, an unusual light- and stress-responsive promoter (psbD LRP) that is regulated by a 19-bp AAG-box immediately upstream of the -35 element has been mapped upstream of the psbD-psbC operon in some angiosperms...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28739808/experiences-of-hiv-postexposure-prophylaxis-pep-among-highly-exposed-men-who-have-sex-with-men-msm
#19
Romain Palich, Guillaume Martin-Blondel, Lise Cuzin, Jean-Yves Le Talec, Pierre Boyer, Patrice Massip, Pierre Delobel
OBJECTIVES: HIV postexposure prophylaxis (PEP) is indicated after sexual exposure with high risk of transmission. Men who have sex with men (MSM) are the main target of PEP. The aim of our study was to investigate the experience and shortcomings of PEP among people with a high risk of HIV exposure. DESIGN AND METHODS: Subjects with ongoing follow-up for HIV infection and PEP history were selected for the qualitative study. Semistructured interviews were conducted at the patients' homes...
July 24, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28734720/rectal-nonsteroidal-anti-inflammatory-drugs-administration-is-effective-for-the-prevention-of-post-ercp-pancreatitis-an-updated-meta-analysis-of-randomized-controlled-trials
#20
Chong Yang, Yanting Zhao, Wentao Li, Shikai Zhu, Hongji Yang, Yu Zhang, Xi Liu, Nan Peng, Ping Fan, Xin Jin
BACKGROUND: Acute pancreatitis is one of the most common complications of endoscopic retrograde cholangiopancreatography (ERCP). Whether the prophylactic administration of rectal non-steroidal anti-inflammatory drugs (NSAIDs) peri-ERCP is effective in preventing post-ERCP pancreatitis (PEP) remains controversial. The aim of this study was to assess the effect of rectal NSAIDs on PEP. METHODS: A systematic search of literature databases (Cochrane Library, PubMed, EMBASE, and Web of Science) was performed to identify eligible randomized controlled trials (RCTs)...
July 17, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
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