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https://www.readbyqxmd.com/read/28230312/five-year-cost-effectiveness-of-patient-empowerment-programme-pep-for-type-2-diabetes-mellitus-in-primary-care
#1
J X Lian, Sarah M McGhee, C So, J Chau, Carlos Kh Wong, William Cw Wong, Cindy Lk Lam
This study evaluated the short-term cost-effectiveness of the Patient Empowerment Programme (PEP) for diabetes mellitus in Hong Kong. Propensity score matching was used to select a matched group of PEP and non-PEP subjects. A societal perspective was adopted to estimate the cost of PEP. The outcome measures were the cumulative incidence of all-cause mortality and diabetic complication over a five-year follow-up and the number needed to treat (NNT) to avoid one event. The incremental cost-effectiveness ratio (ICER) of cost per event avoided was calculated using the PEP cost per subject multiplied by the NNT...
February 23, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28227243/assessment-of-pre-ejection-period-in-ambulatory-subjects-using-seismocardiogram-in-a-wearable-blood-pressure-monitor
#2
Guanqun Zhang, Amber C Cottrell, Isaac C Henry, Devin B McCombie, Guanqun Zhang, Amber C Cottrell, Isaac C Henry, Devin B McCombie, Isaac C Henry, Devin B McCombie, Amber C Cottrell, Guanqun Zhang
The ability to monitor arterial blood pressure continuously with unobtrusive body worn sensors may provide a unique and potentially valuable assessment of a patient's cardiovascular health. Pulse wave velocity (PWV) offers an attractive method to continuously monitoring blood pressure. However, PWV technologies based on timing measurements between the ECG and a distal PPG suffer from inaccuracies on mobile patients due to the confounding influence of pre-ejection period (PEP). In this paper, we presented a wearable, continuous blood pressure monitor (ViSi Mobile) that can measure and track changes in PEP...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223798/transferrin-receptor-targeted-ph-sensitive-micellar-system-for-diminution-of-drug-resistance-and-targetable-delivery-in-multidrug-resistant-breast-cancer
#3
Wei Gao, Guihua Ye, Xiaochuan Duan, Xiaoying Yang, Victor C Yang
The emergence of drug resistance is partially associated with overproduction of transferrin receptor (TfR). To overcome multidrug resistance (MDR) and achieve tumor target delivery, we designed a novel biodegradable pH-sensitive micellar system modified with HAIYPRH, a TfR ligand (7pep). First, the polymers poly(l-histidine)-coupled polyethylene glycol-2000 (PHIS-PEG2000) and 7pep-modified 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000 (7pep-DSPE-PEG2000) were synthesized, and the mixed micelles were prepared by blending of PHIS-PEG2000 and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000 (DSPE-PEG2000) or 7pep-DSPE-PEG2000 (7-pep HD micelles)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28223382/in-vitro-and-in-vivo-activity-of-omadacycline-against-two-biothreat-pathogens-bacillus-anthracis-and-yersinia-pestis
#4
Judith Steenbergen, S Ken Tanaka, Lynda L Miller, Stephanie A Halasohoris, Jeremy R Hershfield
Introduction: The in vitro activity and in vivo efficacy of omadacycline (OMC) were evaluated against the causative pathogens of anthrax and plague, Bacillus anthracis and Yersinia pestis, respectively.Methods: Minimum inhibitory concentrations (MICs) of OMC were determined by microbroth dilution according to CLSI guidelines for 30 isolates each of Y. pestis and B. anthracis The in vivo efficacy of omadacycline was studied at a range of dosages in both a post exposure prophylaxis (PEP) murine model of anthrax and plague as well as in a delayed treatment model of inhalational anthrax...
February 21, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28222578/the-effects-of-prevent-injury-and-enhance-performance-program-in-a-female-soccer-team
#5
Cristina Rodríguez, Soledad Echegoyen, Takeshi Aoyama
BACKGROUND: The purpose of this study is to evaluate the changes of muscle strength in lower limbs and knee valgus alignment using the Prevent Injury and Enhance Performance Program (PEP program) to prevent ACL injuries in female soccer players during an entire season. METHODS: A longitudinal and prospective study was done in twenty female soccer players at the Universidad Nacional Autónoma de México, from a senior team. During 24 weeks the training program was applied three times a week as a part of the team workouts...
February 21, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28221200/pathogenic-link-between-postextubation-pneumonia-and-ventilator-associated-pneumonia-an-experimental-study
#6
Emanuele Rezoagli, Alberto Zanella, Massimo Cressoni, Lorenzo De Marchi, Theodor Kolobow, Lorenzo Berra
BACKGROUND: The presence of an endotracheal tube is the main cause for developing ventilator-associated pneumonia (VAP), but pneumonia can still develop in hospitalized patients after endotracheal tube removal (postextubation pneumonia [PEP]). We hypothesized that short-term intubation (24 hours) can play a role in the pathogenesis of PEP. To test such hypothesis, we initially evaluated the occurrence of lung colonization and VAP in sheep that were intubated and mechanically ventilated for 24 hours...
February 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28216188/rationale-and-support-for-a-one-health-program-for-canine-vaccination-as-the-most-cost-effective-means-of-controlling-zoonotic-rabies-in-endemic-settings
#7
REVIEW
Robert P Lavan, Alasdair I MacG King, David J Sutton, Kaan Tunceli
Although dog vaccination has been demonstrated to reduce and eliminate rabies in humans, during meetings there are often calls for further pilot studies. The assembled data proves that a widespread approach is now required. While zoonotic rabies has a minimal presence in developed nations, it is endemic throughout most of Asia and Africa, where it is considered to be a neglected tropical disease. In these areas, rabies causes an estimated annual mortality of at least 55,000 human deaths. Worldwide rabid dogs are the source of the vast majority of human rabies exposures...
February 16, 2017: Vaccine
https://www.readbyqxmd.com/read/28209101/role-of-heart-rate-variability-in-predicting-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis
#8
Y Tryliskyy, G J Bryce
INTRODUCTION: Early recognition of post-ERCP pancreatitis (PEP) would help deliver an appropriate discharge plan following ERCP. Functioning of the autonomic nervous system can be measured using non-invasive heart rate variability techniques (HRV) and provides quantitative information about the modulation of cardiac vagal and sympathetic activity. Pain evoked sympathetic activation is a well-known phenomenon, as exhibited in those suffering PEP. The aim of this study is to determine if a single post-procedural measurement of HRV identifies those at risk of developing PEP...
September 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/28196066/cancer-related-fatigue-management-evaluation-of-a-patient-education-program-with-a-large-scale-randomised-controlled-trial-the-peps-fatigue-study
#9
A Bourmaud, A Anota, C Moncharmont, F Tinquaut, M Oriol, V Trillet-Lenoir, A Bajard, S Parnalland, C Rotonda, F Bonnetain, D Pérol, F Chauvin
BACKGROUND: To assess the efficacy of a patient educational program built according to guidelines that aims at reducing cancer-related fatigue (CRF). METHODS: Randomised controlled trial, multicentre, comparing a patient education program, vs the standard of care. Patients were adult cancer outpatients with any tumour site. The primary outcome was fatigue severity assessed with a visual analogical scale (VAS), between the day of randomisation and week 7. Secondary outcomes were fatigue assessed with other scales, health-related quality of life, anxiety and depression...
February 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28194668/value-of-raw-rhubarb-solution-in-the-precaution-of-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-in-patients-with-high-risk-factors-a-predictive-random-compared-research-in-one-center
#10
Chong Wang, Qirui Li, Peng Ye, Sheng Zeng, Guo-Hua Li, You-Xiang Chen, Xiao-Jiang Zhou, Nong-Hua Lv
BACKGROUND AND AIMS: Post-ERCP pancreatitis and hyperamylasemia are common complications of endoscopic retrograde cholangiopancreatography (ERCP), especially in high-risk patients. The aim of this study is to evaluate whether a raw rhubarb solution can reduce the incidence of PEP and post-ERCP hyperamylasemia. METHODS: From October 2012 to October 2013, 2100 patients received ERCP in our Endoscopic Center. Five hundred patients with high-risk factors were enrolled randomly into the raw rhubarb group (RG, 250 cases drank a raw rhubarb soak solution per 3 h until defecation after ERCP) and the control group (CG, 250 cases drank water after ERCP) in the study...
February 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28194450/assessment-of-the-adjuvant-activity-of-mesoporous-silica-nanoparticles-in-recombinant-mycoplasma-hyopneumoniae-antigen-vaccines
#11
Veridiana Gomes Virginio, Natalia Costantin Bandeira, Fernanda Munhoz Dos Anjos Leal, Marcelo Lancellotti, Arnaldo Zaha, Henrique Bunselmeyer Ferreira
The adjuvant potential of two mesoporous silica nanoparticles (MSNs), SBa-15 and SBa-16, was assessed in combination with a recombinant HSP70 surface polypeptide domain from Mycoplasma hyopneumoniae, the etiological agent of porcine enzootic pneumonia (PEP). The recombinant antigen (HSP70212-600), previously shown as immunogenic in formulation with classic adjuvants, was used to immunize BALB/c mice in combination with SBa-15 or SBa-16 MSNs, and the effects obtained with these formulations were compared to those obtained with alum, the adjuvant traditionally used in anti-PEP bacterins...
January 2017: Heliyon
https://www.readbyqxmd.com/read/28193422/sulphonated-modification-of-polysaccharides-from-pleurotus-eryngii-and-streptococcus-thermophilus-ascc-1275-and-antioxidant-activities-investigation-using-ccd-and-caco-2-cell-line-models
#12
Siqian Li, Nagendra P Shah
Polysaccharides extracted from Pleurotus eryngii (PEPS) and Streptococcus thermophilus ASCC 1275 (EPS) were sulphonated and their composition determined. Antioxidant activities of crude and sulphonated polysaccharides (S.PEPS and S.EPS) were investigated using the ABTS radical scavenging test and CCD and Caco-2 cell models. Degrees of sulphonation for S.PEPS and S.EPS were 0.73 and 0.37, respectively. Results showed that S.PEPS and S.EPS had significantly higher scavenging capacities than PEPS and EPS in the ABTS radical scavenging test...
June 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28190830/f%C3%A3-rster-resonance-energy-transfer-mediated-photoluminescence-quenching-in-stoichiometrically-assembled-cdse-zns-quantum-dot-peptide-labeled-black-hole-quencher-conjugates-for-matrix-metalloproteinase-2-sensing
#13
Sreenadh Sasidharan Pillai, Hiroshi Yukawa, Daisuke Onoshima, Vasudevanpillai Biju, Yoshinobu Baba
The steady state and time-resolved photoluminescence quenching of streptavidin modified CdSe/ZnS quantum dots (QDs) instigated by biotin-peptide-BHQ-1 (biotin-pep-BHQ-1) molecule was investigated. Here, we have achieved an efficient photoluminescence (PL) quenching of QDs with the conjugation of dark quencher (black hole quencher-BHQ) molecules intermediated with the GPLGVRGK peptide. The luminescence of streptavidin-QDs585 was decreased upon titration with a nano molar concentration of the biotin-GPLGVRGK-BHQ-1 molecule...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28185786/the-course-of-negative-symptoms-in-first-episode-schizophrenia-and-its-predictors-a-prospective-two-year-follow-up-study
#14
Gisela Mezquida, Bibiana Cabrera, Miquel Bioque, Silvia Amoretti, Antonio Lobo, Ana González-Pinto, Ana Espliego, Iluminada Corripio, Eduard Vieta, Josefina Castro-Fornieles, Daniel Bergé, Maria J Escartí, Ángela Ibañez, Rafael Penadés, Ana M Sánchez-Torres, Miguel Bernardo
AIMS: This study aimed to investigate the course of negative symptoms and its stability over a two-year period following a first-episode schizophrenia (FES) and the possible predictors of higher severity in this symptomatology after this period. METHODS: In this longitudinal two-year prospective follow-up study we included 268 patients with a FES, according to DSM-IV. Analysis of variance was conducted in patients who completed the full follow-up to study changes in negative symptoms over three visits...
February 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28179063/modelling-gene-environment-interaction-in-first-episodes-of-psychosis
#15
Miguel Bernardo, Miquel Bioque, Bibiana Cabrera, Antonio Lobo, Ana González-Pinto, Laura Pina, Iluminada Corripio, Julio Sanjuán, Anna Mané, Josefina Castro-Fornieles, Eduard Vieta, Celso Arango, Gisela Mezquida, Patricia Gassó, Mara Parellada, Jerónimo Saiz-Ruiz, Manuel J Cuesta, Sergi Mas
INTRODUCTION: Recent research demonstrates the heterogeneous etiology of psychotic disorders, where gen-environment (GxE) interaction plays a key role. Large genetic studies have linked many genetic variants with schizophrenia, but each variant is only associated with a small effect and the GxE interaction contribution has not been evaluated. METHODS: The PEPs Project was designed to carefully collect a large amount of genetic and environmental exposure data of 335 FEP patients and 253 matched healthy controls...
February 5, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28178088/aggressive-hydration-with-lactated-ringer-solution-in-prevention-of-postendoscopic-retrograde-cholangiopancreatography-pancreatitis-a-meta-analysis-of-randomized-controlled-trials
#16
Zhi-Feng Zhang, Zhi-Jun Duan, Li-Xia Wang, Gang Zhao, Wu-Guo Deng
BACKGROUND: Pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP). The results of previous studies evaluating aggressive hydration with lactated Ringer solution for reducing the incidence of post-ERCP pancreatitis (PEP) are inconsistent. AIM: We performed a meta-analysis to determine whether aggressive hydration with lactated Ringer solution reduced PEP. METHODS: Randomized controlled trials (RCTs) comparing aggressive hydration with standard hydration with the same lactated Ringer solution for prophylaxis of PEP were searched in PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL databases...
March 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28177705/aerobic-capacity-is-not-improved-following-10-day-supplementation-with-peppermint-essential-oil
#17
Kyle Shepherd, Daniel James Peart
This study examined the effects of peppermint essential oil (PEP) on aerobic capacity. Seven healthy participants performed a graded maximal exercise test following 10-days of ingesting either PEP or a control in a randomised cross-over design. There was no significant difference between control and PEP trials for expired gas variables (V ̇O2 peak 3.54 vs. 3.52 L/min) or performance measures (time to exhaustion 583.33 vs. 587.04 seconds). Similarly, resting cardio-pulmonary measures were also unchanged between visits...
January 30, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28171691/toward-routine-use-of-nonsteroidal-anti-inflammatory-drugs-for-patients-undergoing-endoscopic-retrograde-cholangiopancreatography
#18
EDITORIAL
Tsuyoshi Hamada, Yousuke Nakai, Hiroyuki Isayama, Kazuhiko Koike
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used pharmacological prevention strategy for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP).(1,2) Experimental data suggest that NSAIDs, a group of inhibitors of PTGS1 (cyclooxygenase-1 or COX-1) and PTGS2 (cyclooxygenase-2 or COX-2), can prevent PEP through inhibition of phospholipase A2 which plays a key role in triggering inflammatory response in the pancreas.(3) Given accumulating evidence from clinical trials, peri-procedural use of rectal NSAIDs is considered as an established strategy for prevention of PEP, at least for patients who have risk factors for PEP including younger age, suspected sphincter of Oddi dysfunction as an indication, and a history of pancreatitis...
February 7, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28170304/hiv-pre-exposure-prophylaxis-and-postexposure-prophylaxis-in-japan-context-of-use-and-directions-for-future-research-and-action
#19
Anthony S DiStefano, Makiko Takeda
Biomedical HIV prevention strategies are playing an increasingly prominent role in addressing HIV epidemics globally, but little is known about their use in Japan, where persistent HIV disparities and a recently stable, but not declining, national epidemic indicate the need for evolving approaches. We conducted an ethnographic study to determine the context of pre-exposure prophylaxis (PrEP) and postexposure prophylaxis (PEP) use and to identify directions for future research and action in Japan. We used data from observational fieldwork in the Kansai region and Tokyo Metropolitan Area (n = 178 persons observed), qualitative interviews (n = 32), documents and web-based data sources (n = 321), and email correspondences (n = 9) in the period 2013-2016...
February 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28169914/cardiac-autonomic-function-and-hot-flashes-among-perimenopausal-and-postmenopausal-women
#20
Carolyn J Gibson, Wendy Berry Mendes, Michael Schembri, Deborah Grady, Alison J Huang
OBJECTIVE: Abnormalities in autonomic function are posited to play a pathophysiologic role in menopausal hot flashes. We examined relationships between resting cardiac autonomic activity and hot flashes in perimenopausal and postmenopausal women. METHODS: Autonomic function was assessed at baseline and 12 weeks among perimenopausal and postmenopausal women (n = 121, mean age 53 years) in a randomized trial of slow-paced respiration for hot flashes. Pre-ejection period (PEP), a marker of sympathetic activation, was measured with impedance cardiography...
February 6, 2017: Menopause: the Journal of the North American Menopause Society
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