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https://www.readbyqxmd.com/read/28423562/circulating-tumor-cells-in-early-stage-lung-adenocarcinoma-a-case-series-report-and-literature-review
#1
Xu-Rui Jin, Lu-Yao Zhu, Kai Qian, Yong-Geng Feng, Jing-Hai Zhou, Ru-Wen Wang, Li Bai, Bo Deng, Naixin Liang, Qun-You Tan
PURPOSE: The study aimed to monitor circulating tumor cells (CTCs) in early stage lung adenocarcinoma patients. RESULTS: CTCs were characterized and classified to epithelial (E-) CTCs, mesenchymal (M-) CTCs and epithelial- mesenchymal (E&M-) CTCs, as per epithelial-mesenchymal transition(EMT) biomarkers. CTCs could not be found in healthy controls. However, in cohort A, CTCs were found in 17 (17/18) cases. Detection rate of E-CTCs was lower (5/18) compared with M-CTC (10/18) or E&M-CTC (14/18)...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422382/quantum-dots-based-fluorescence-resonance-energy-transfer-biosensor-for-monitoring-cell-apoptosis
#2
Chunchuan Gu
The development of advanced methods for accurately monitoring cell apoptosis has extensive significance in the diagnostic and pharmaceutical fields. In this study, we developed a rapid, sensitive and selective approach for the detection of cell apoptosis by combining the site-specific recognition and cleavage of the DEVD-peptide with quantum dots (QDs)-based fluorescence resonance energy transfer (FRET). Firstly, biotin-peptide was conjugated on the surface of AuNPs to form AuNPs-pep through the formation of an Au-S bond...
April 19, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28421186/cost-description-and-comparative-cost-efficiency-of-post-exposure-prophylaxis-and-canine-mass-vaccination-against-rabies-in-n-djamena-chad
#3
Rolande Mindekem, Monique Sarah Lechenne, Kemdongarti Service Naissengar, Assandi Oussiguéré, Bidjeh Kebkiba, Daugla Doumagoum Moto, Idriss Oumar Alfaroukh, Laurent Tinoanga Ouedraogo, Sahidou Salifou, Jakob Zinsstag
Rabies claims approximately 59,000 human lives annually and is a potential risk to 3.3 billion people in over 100 countries worldwide. Despite being fatal in almost 100% of cases, human rabies can be prevented by vaccinating dogs, the most common vector, and the timely administration of post-exposure prophylaxis (PEP) to exposed victims. For the control and prevention of human rabies in N'Djamena, the capital city of Chad, a free mass vaccination campaign for dogs was organized in 2012 and 2013. The campaigns were monitored by parallel studies on the incidence of canine rabies based on diagnostic testing of suspect animals and the incidence of human bite exposure recorded at selected health facilities...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28418324/prosody-perception-and-production-in-children-with-hearing-loss-and-age-and-gender-matched-controls
#4
Rose Thomas Kalathottukaren, Suzanne C Purdy, Elaine Ballard
BACKGROUND: Auditory development in children with hearing loss, including the perception of prosody, depends on having adequate input from cochlear implants and/or hearing aids. Lack of adequate auditory stimulation can lead to delayed speech and language development. Nevertheless, prosody perception and production in people with hearing loss have received less attention than other aspects of language. The perception of auditory information conveyed through prosody using variations in the pitch, amplitude, and duration of speech is not usually evaluated clinically...
April 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28416980/comparison-of-the-measured-pre-ejection-periods-and-left-ventricular-ejection-times-between-echocardiography-and-impedance-cardiography-for-optimizing-cardiac-resynchronization-therapy
#5
Kazuki Noda, Hideaki Endo, Takahide Kadosaka, Takashi Nakata, Tasuku Watanabe, Yosuke Terui, Shoko Kajitani, Yuto Monnma, Kenjiro Sato, Masanori Kanazawa, Sota Nakajima, Masateru Kondo, Tohru Takahashi, Akihiro Nakamura, Eiji Nozaki
BACKGROUND: The pre-ejection period (PEP) and left ventricular ejection time (LVET) are easily measured by impedance cardiography (ICG). We hypothesized that the PEP/LVET measured by ICG would correlate with that measured by echocardiography, and that PEP/LVET measured by ICG would be useful for cardiac resynchronization therapy (CRT) optimization. METHODS: Newly CRT implanted patients were optimized by echocardiography. The PEP/LVET was measured by echocardiography and ICG in two different settings: optimized setting and right ventricle (RV)-only pacing...
April 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28415898/-31-phosphorus-magnetic-resonance-spectroscopy-of-the-liver-for-evaluating-inflammation-and-fibrosis-in-autoimmune-hepatitis
#6
Lauri Puustinen, Antti Hakkarainen, Reetta Kivisaari, Sonja Boyd, Urpo Nieminen, Martti Färkkilä, Nina Lundbom, Perttu Arkkila
BACKGROUND: Liver biopsy is the gold standard in evaluating inflammation and fibrosis in autoimmune hepatitis. AIMS: In search of non-invasive follow-up tools in autoimmune hepatitis, we evaluated (31)phosphorus magnetic resonance spectroscopy ((31)P MRS). METHODS: Twelve consecutive AIH patients (mean age 42.8 years, 10 women) underwent liver biopsy, routine laboratory liver function tests, which were compared to findings in (31)P MRS and transient elastography (TE)...
April 17, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28414557/polydopamine-and-peptide-decorated-doxorubicin-loaded-mesoporous-silica-nanoparticles-as-a-targeted-drug-delivery-system-for-bladder-cancer-therapy
#7
Yi Wei, Li Gao, Lu Wang, Lin Shi, Erdong Wei, Baotong Zhou, Li Zhou, Bo Ge
We reported a simple polydopamine (PDA)-based surface modification method to prepare novel targeted doxorubicin-loaded mesoporous silica nanoparticles and peptide CSNRDARRC conjugation (DOX-loaded MSNs@PDA-PEP) for enhancing the therapeutic effects on bladder cancer. Drug-loaded NPs were characterized in terms of size, size distribution, zeta potential, transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) surface area and drug loading content. In vitro drug release indicated that DOX-loaded MSNs@PDA and MSNs@PDA-PEP had similar release kinetic profiles of DOX...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28413818/data-on-enhanced-expression-and-purification-of-camelid-single-domain-antibodies-from-escherichia-coli-classical-inclusion-bodies
#8
Maristella Maggi, Claudia Scotti
Heterologous expression of high amounts of recombinant proteins is a milestone for research and industrial purposes. Single domain antibodies (sdAbs) are heavy-chain only antibody fragments with applications in the biotechnological, medical and industrial fields. The simple nature and small size of sdAbs allows for efficient expression of the soluble molecule in different hosts. However, in some cases, it results in low functional protein yield. To overcome this limitation, expression of a 6xHistag sdAb was attempted in different conditions in Escherichia coli BL21(DE3) cells...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28411506/the-ten-year-course-of-depression-in-primary-care-and-long-term-effects-of-psychoeducation-psychiatric-consultation-and-cognitive-behavioral-therapy
#9
Henk Jan Conradi, Elisabeth H Bos, Jan H Kamphuis, Peter de Jonge
BACKGROUND: While the majority of depressed patients are treated in primary care, long-term follow-up data on the naturalistic course of depression and treatment effectiveness in this setting are scarce. This study examined the ten-year course of depression in primary care patients who had participated in a randomized clinical trial aiming at enhancement of depression outcomes. METHODS: Of the original sample (n=267), 166 patients participated in the ten-year follow-up; missingness was random...
March 30, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28407206/pre-ejection-period-reactivity-to-reward-is-associated-with-anhedonic-symptoms-of-depression-among-adolescents
#10
Joshua J Ahles, Amy H Mezulis, Sheila E Crowell
Pre-ejection period (PEP) reactivity to reward has been posited as a specific index of behavioral approach and incentive motivation, suggesting it might be uniquely associated with the affective and motivational deficits of anhedonia. This study evaluated PEP reactivity to a reward task as a predictor of depressive symptoms among adolescents, examining global depressive symptoms as well as specific anhedonic and nonanhedonic symptoms clusters. Participants included 76 adolescents, ages 11-15 years (52% female)...
April 13, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28406045/a-methacrylic-hyaluronic-acid-derivative-for-potential-application-in-oral-treatment-of-celiac-disease
#11
Giovanna Pitarresi, Fabio Salvatore Palumbo, Daniela Triolo, Calogero Fiorica, Gaetano Giammona
OBJECTIVE: Aim of this work was the synthesis of a methacrylic hyaluronic acid derivative and the production, via photocrosslinking, of related hydrogels loaded with an endopeptidase intended for a potential oral treatment of celiac disease. METHODS: The methacrylic derivative of hyaluronic acid (HA) was prepared through a one-pot procedure involving the reaction with ethylenediamine (EDA) and methacrylic anhydride (MA). The obtained derivative, named HA-EDA-MA, was used to prepare photocrosslinked hydrogels loaded with a prolyl endopeptidase derived from Flavobacterium meningosepticum (PEP FM) able to detoxify gliadin...
April 13, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28405745/lethal-albinic-seedling-encoding-a-threonyl-trna-synthetase-is-involved-in-development-of-plastid-protein-synthesis-system-in-rice
#12
Yuan-Yan Zhang, Yuan-Yuan Hao, Yi-Hua Wang, Chun-Ming Wang, Yun-Long Wang, Wu-Hua Long, Di Wang, Xi Liu, Ling Jiang, Jian-Min Wan
An albinic rice is caused by mutation of threonyl-tRNA synthetase, which is essential for plant development by stabilizing of NEP and PEP gene expressions and chloroplast protein synthesis. Chloroplast biogenesis and development depend on complex genetic mechanisms. Apart from their function in translation, aminoacyl-tRNA synthetases (aaRSs) play additional role in gene expression regulation, RNA splicing, and cytokine activity. However, their detailed functions in plant development are still poorly understood...
April 12, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28405329/the-impact-of-prophylactic-pancreatic-stenting-on-post-ercp-pancreatitis-a-nationwide-register-based-study
#13
Greger Olsson, Jeanne Lübbe, Urban Arnelo, Eduard Jonas, Björn Törnqvist, Lars Lundell, Lars Enochsson
BACKGROUND AND OBJECTIVES: The role of prophylactic pancreatic stenting (PS) in preventing post-endoscopic retrograde cholangio-pancreatography (ERCP) pancreatitis (PEP) has yet to be determined. Most previous studies show beneficial effects in reducing PEP when prophylactic pancreatic stents are used, especially in high-risk ERCP procedures. The present study aimed to address the use of PS in a nationwide register-based study in which the primary outcome was the prophylactic effect of PS in reducing PEP...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28403542/chiral-analysis-of-ammuxetine-enantiomers-in-dog-plasma-using-online-spe-liquid-chromatography-with-tandem-mass-spectrometric-detection-after-precolumn-chiral-derivatization
#14
Jimei Yu, Xin Li, Jiezhao Zhou, Xiangyang Xie, Meiling Chen, Xinhua He, Yang Yang, Youzhi Zhang, Aiping Zheng, Xingguo Mei, Ying Li
Ammuxetine (AMT), a novel chiral antidepressant candidate compound, exhibits better antidepression effects than duloxetine in different animal models. In this article, a chiral derivatization method, combined with online solid phase extraction (online SPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), was developed for the chiral separation of AMT enantiomers after administration of racemic AMT to dogs. The derivatization reaction employed 2,3,4,6-tetra-O-acetyl-b-glucopyr-anosyl isothiocyanate (GITC) as a precolumn chiral derivatization reagent...
April 12, 2017: Chirality
https://www.readbyqxmd.com/read/28392140/estimated-protective-effectiveness-of-intramuscular-immune-serum-globulin-post-exposure-prophylaxis-during-a-measles-outbreak-in-british-columbia-canada-2014
#15
Mark Bigham, Michelle Murti, Christina Fung, Felicity Hemming, Susan Loadman, Robert Stam, Paul Van Buynder, Marcus Lem
INTRODUCTION: Intramuscular Immune Serum Globulin (IM ISG) is recommended as post-measles exposure prophylaxis (PEP) when administered within 6days of initial exposure, with variable effectiveness in preventing measles disease. Effectiveness of IM ISG PEP in preventing clinical measles was assessed during a 2014 measles outbreak among a religious-affiliated community in British Columbia, Canada. MATERIAL AND METHODS: Fifty-five self-reporting measles susceptible contacts were offered exclusively IM ISG PEP within an eligibility period best surmised to be within 6days of initial measles case exposure...
April 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28389049/intuitive-pharmacogenetic-dosing-of-risperidone-according-to-cyp2d6-phenotype-extrapolated-from-genotype-in-a-cohort-of-first-episode-psychosis-patients
#16
Sergi Mas, Patricia Gassó, Mercé Torra, Miquel Bioque, Antonio Lobo, Ana González-Pinto, Maria Soledad Olmeda, Iluminada Corripio, Eduard Vieta, Josefina Castro-Fornieles, Roberto Rodriguez-Jimenez, Julio Bobes, Judith Usall, Adrián Llerena, Jerónimo Saiz-Ruiz, Miguel Bernardo, Amalia Lafuente, PEPs Group
Risperidone (R) is the most prescribed antipsychotic drug for patients with a first episode of psychosis (FEP). In a naturalistic cohort of chronic psychiatric inpatients, we demonstrated that clinicians adjust R dosage by CYP2D6 activity, despite being blinded to the genotype, which we described as an "intuitive pharmacogenetic" process. The aim of the present study is to replicate our previous findings of intuitive pharmacogenetic in a cohort of FEP patients using CYP2D6 phenotype extrapolated from genotypes...
April 4, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28388582/peptide-based-pet-imaging-of-the-tumor-restricted-il13ra2-biomarker
#17
Kiran Kumar Solingapuram Sai, Anirudh Sattiraju, Frankis G Almaguel, Ang Xuan, Stephanie Rideout, Rahul S Krishnaswamy, JoAnn Zhang, Denise M Herpai, Waldemar Debinski, Akiva Mintz
Peptides that target cancer cell surface receptors are promising platforms to deliver diagnostic and therapeutic payloads specifically to cancer but not normal tissue. IL13RA2 is a tumor-restricted receptor found to be present in several aggressive malignancies, including in the vast majority of high-grade gliomas and malignant melanoma. This receptor has been successfully targeted for diagnostic and therapeutic purposes using modified IL-13 ligand and more recently using a specific peptide, Pep-1L. In the current work, we establish the in vitro and in vivo tumor binding properties of radiolabeled Pep-1L, designed for tumor imaging...
March 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28377494/arabidopsis-fructokinase-like-protein-associations-are-regulated-by-atp
#18
John W Riggs, Judy Callis
The Arabidopsis thaliana FRUCTOKINASE-LIKE PROTEINs FLN1 and FLN2 are required for the differentiation of plastids into photosynthetically-competent chloroplasts. However, their specific roles are unknown. FLN1 and FLN2 localize in a multi-subunit prokaryotic-type polymerase (PEP) complex that transcribes genes encoding components of photosynthesis-related assemblies. Despite sequence identity to fructokinases, which are members of the pfkB family of enzymes, kinase activity of FLN1 and FLN2 has not been demonstrated...
April 4, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28374181/diclofenac-does-not-reduce-the-risk-of-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-in-low-risk-units
#19
Mia Rainio, Outi Lindström, Marianne Udd, Johanna Louhimo, Leena Kylänpää
BACKGROUND: Nonsteroidal anti-inflammatory drugs have an inhibitory role in pathogenesis of pancreatitis. Guidelines from the European Society of Gastrointestinal Endoscopy recommend routine rectal administration of 100 mg of diclofenac or indomethacin immediately before or after ERCP for all patients without contraindications. AIMS: Our aim was to evaluate the effect of diclofenac in preventing post-ERCP pancreatitis (PEP) in a high-volume, low-PEP-risk ERCP unit...
April 3, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28374116/designing-an-escherichia-coli-strain-for-phenylalanine-overproduction-by-metabolic-engineering
#20
Neetu Tyagi, Deepti Saini, Richa Guleria, Krishna Jyoti Mukherjee
The phenylalanine pathway flux is controlled by two types of regulators, those that are specific to the pathway, as well as by global regulators. In order to demonstrate the importance of these global regulators, we first removed the pathway-specific regulators using all possible combinations of gene knockouts and knockins. We found that genes like aroG (fbr) performed best individually as well as in combination with other genes, while other genes like tyrA and tyrR worked only in combination with other modifications...
April 3, 2017: Molecular Biotechnology
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