Roshan Kumari, Michael E Ponte, Edziu Franczak, John C Prom, Maura F O'Neil, Mihaela E Sardiu, Andrew J Lutkewitte, Lane K Christenson, Kartik Shankar, E Matthew Morris, John P Thyfault
Menopause adversely impacts systemic energy metabolism and increases the risk of metabolic disease(s) including hepatic steatosis, but the mechanisms are largely unknown. Dosing female mice with vinyl cyclohexene dioxide (VCD) selectively causes follicular atresia in ovaries, leading to a murine menopause-like phenotype. In this study, we treated female C57BL6/J mice with VCD (160mg/kg i.p. for 20 consecutive days followed by verification of the lack of estrous cycling) to investigate changes in body composition, energy expenditure (EE), hepatic mitochondrial function, and hepatic steatosis across different dietary conditions...
March 1, 2024: Molecular Metabolism