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Menopause AND weight loss

Ellen B Gold, Sybil L Crawford, Janie F Shelton, Ping G Tepper, Carolyn J Crandall, Gail A Greendale, Karen A Matthews, Rebecca C Thurston, Nancy E Avis
OBJECTIVE: Greater body mass index (BMI) and body fat are associated with vasomotor symptoms (VMS). Thus, weight loss may prevent VMS. We analyzed whether concurrent BMI or waist circumference and/or changes in weight or waist circumference predicted incident VMS and whether these relations differed by menopause stage or race/ethnicity. METHODS: Data from 10 follow-up visits for 1,546 participants in the Study of Women's Health Across the Nation who reported no VMS at baseline were modeled for time to first symptomatic visit in relation to concurrent BMI and waist circumference and change in weight and waist circumference during early and late menopause using discrete survival analyses, adjusting for covariates...
October 3, 2016: Menopause: the Journal of the North American Menopause Society
Maninder Ahuja
INTRODUCTION: Age of menopause is a very important biomarker of not only the loss of fertility but also an increased risk for various mid-life diseases and problems. Many of these diseases can be prevented by timely intervention of lifestyle modification, menopausal hormone therapy, or other supplementations such as calcium, Vitamin D, and micronutrients. In India age of menopause is less than our counterparts in the Western world. This means that the fertility potential of Indian women starts compromising early, so we need to start with the preventive measures much early...
July 2016: Journal of Mid-life Health
Jennifer D Brooks, Esther M John, Lene Mellemkjaer, Charles F Lynch, Julia A Knight, Kathleen E Malone, Anne S Reiner, Leslie Bernstein, Xiaolin Liang, Roy E Shore, Marilyn Stovall, Jonine L Bernstein
Studies examining the relationship between body mass index (BMI) and risk of contralateral breast cancer (CBC) have reported mixed findings. We previously showed that obese postmenopausal women with estrogen receptor (ER)-negative breast cancer have a fivefold higher risk of CBC compared with normal weight women. In the current analysis, we reexamined this relationship in the expanded Women's Environmental Cancer and Radiation Epidemiology (WECARE) Study, focusing on the impact of menopausal status and ER status of the first breast cancer...
October 3, 2016: Cancer Medicine
Maude Dulac, Guy El Hajj Boutros, Charlotte Pion, Sébastien Barbat-Artigas, Gilles Gouspillou, Mylène Aubertin-Leheudre
Objective: To investigate whether handgrip strength normalized to body weight could be a useful clinical tool to identify dynapenia and assess functional capacity in post-menopausal women. Method: A total of 136 postmenopausal women were recruited. Body composition (Dual Energy X-ray Absorptiometry [DEXA], Bio-electrical Impedence Analysis [BIA]), grip strength (dynamometer) and functional capacity (senior fitness tests) were evaluated. Dynapenia was established according to a handgrip strength index (handgrip strength divided by body weight (BW) in Kg/KgBW) obtained from a reference population of young women: Type I dynapenic (<0...
September 15, 2016: Brazilian Journal of Physical Therapy
Laura D Bilek, Nancy L Waltman, Joan M Lappe, Kevin A Kupzyk, Lynn R Mack, Diane M Cullen, Kris Berg, Meghan Langel, Melissa Meisinger, Ashlee Portelli-Trinidad, Molly Lang
BACKGROUND: In the United States, over 34 million American post-menopausal women have low bone mass (osteopenia) which increases their risk of osteoporosis and fractures. Calcium, vitamin D and exercise are recommended for prevention of osteoporosis, and bisphosphonates (BPs) are prescribed in women with osteoporosis. BPs may also be prescribed for women with low bone mass, but are more controversial due to the potential for adverse effects with long-term use. A bone loading exercise program (high-impact weight bearing and resistance training) promotes bone strength by preserving bone mineral density (BMD), improving bone structure, and by promoting bone formation at sites of mechanical stress...
2016: BMC Women's Health
Birgith Pedersen, Charlotte Delmar, Mette Dahl Bendtsen, Ingvar Bosaeus, Andreas Carus, Ursula Falkmer, Mette Groenkjaer
BACKGROUND: Antineoplastic adjuvant treatment for breast cancer can cause changes in women's weight and body composition and influence their general health and survival. OBJECTIVE: The aim of this study is to investigate the extent and patterns of change in weight and body composition after current standard adjuvant antineoplastic treatment for breast cancer. METHODS: Data on weight and body composition from 95 women with breast cancer Stage I to III were obtained during 18 months on a bioelectric impedance analyzer...
August 16, 2016: Cancer Nursing
Ashley J Vargas, John Quackenbush, Kimberly Glass
BACKGROUND: Weight loss may decrease risk of colorectal cancer in obese individuals, yet its effect in the colorectum is not well understood. We used integrative network modeling, Passing Attributes between Networks for Data Assimilation, to estimate transcriptional regulatory network models from mRNA expression levels from rectal mucosa biopsies measured pre- and post-weight loss in 10 obese, pre-menopausal women. RESULTS: We identified significantly greater regulatory targeting of glucose transport pathways in the post-weight loss regulatory network, including "regulation of glucose transport" (FDR=0...
August 11, 2016: Genomics
A Vargas-Meza, M Chavez-Tostado, A O Cortes-Flores, D Urias-Valdez, M Delgado-Gomez, G Morgan-Villela, C Zuloaga-Fernandez Del Valle, J Jimenez-Tornero, R Zuloaga-Fernandez Del Valle, C Fuentes-Orozco, J García-Rentería, J Rendón-Félix, L Cuesta-Márquez, A Gonzalez-Ojeda
Weight gain is observed in breast cancer patients receiving chemotherapy and is a well-known complication. Several factors that contributing to weight gain have been identified. However, there is a lack of information about factors associated with weight changes following adjuvant chemotherapy. A retrospective cohort of 200 pre- and post-menopausal Mexican patients treated for breast cancer was made. Anthropometric variables were measured before/after treatment. Biomarkers, cellular differentiation and chemotherapy were similar between groups...
August 1, 2016: European Journal of Cancer Care
Sridhar Muthusami, Vasudevan Gopalakrishnan, Jone A Stanley, Senthilkumar Krishnamoorthy, Ramachandran Ilangovan, Velliyur K Gopalakrishnan, Narasimhan Srinivasan
UNLABELLED: The increasing evidence suggesting the role of free radicals in bone resorption and bone loss prompted us to explore whether the consumption of antioxidant rich medicinal plant C. quadrangularis modifies antioxidant status in ovariectomized rats. METHODS: Twenty four female adult rats, 90days old showing regular estrous cycles were used for the present study. The animals were divided into two groups. The Group-1 rats (n=6) were sham operated and Group-II rats were bilaterally ovariectomized (n=18) and treated with C...
July 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Hironobu Asai, Sachie Nakatani, Takuya Kato, Tatsuo Shimizu, Hiroshi Mano, Kenji Kobata, Masahiro Wada
The effect of glucosamine (GlcN) and N-acetylglucosamine (GlcNAc) on bone metabolism in ovariectomized (OVX) mice was studied. After 12 weeks of feeding with 0.2% GlcN and 0.2% GlcNAc, the femoral bone mineral density in OVX mice was significantly increased compared with that in OVX mice fed the control diet. Histomorphometric analysis of the tibia indicated that the rates of osteogenesis and bone resorption were reduced due to the GlcN diet. The erosion depth of osteoclasts on the tibia in GlcN- and GlcNAc-fed OVX mice was significantly lower than that in the control OVX mice...
2016: Biological & Pharmaceutical Bulletin
Paolo Emilio Puddu, Michele Schiariti, Concetta Torromeo
BACKGROUND: There are no ready explanations for differences in ischemic heart disease incidence between women and men under an epidemiological perspective. However, when myocardial infarction occurs, there are more likely individuals who happen to die. METHODS: This review from a more recent literature was performed for a two-fold purpose, to describe gender wise: a) the role of classical and novel factors defined to evaluate coronary artery disease (CAD) risk and mortality, aimed at assessing applicability and relevance for primary and secondary prevention; b) the differences in northern versus southern European Countries in risk factors and CAD mortality...
2016: Current Pharmaceutical Design
Seong Hee Ahn, Seokhyeon Lee, Hyeonmok Kim, Seung Hun Lee, Beom-Jun Kim, Jung-Min Koh
PURPOSE: Despite the clear effect of iron on bone metabolism, most clinical studies related to bone health have only focused on bone mineral density (BMD). In the present study, we investigated the relationship between serum ferritin and composite indices of femur neck strength via a population-based, cross-sectional study using the Korea National Health and Nutrition Examination Survey (KNHANES). METHODS: Our study series included 693 women at the stage of bone loss (≥ 45 years of age), defined based on the observed patterns of age-related BMD changes in the KNHANES...
April 4, 2016: Endocrine Research
S J Hopkins, A D Toms, M Brown, J R Welsman, O C Ukoumunne, K M Knapp
UNLABELLED: Significant increased hip fracture incidence has been reported in the year following total knee replacement. This study demonstrates that bone and muscle loss is a post-surgical consequence of total knee replacement, alongside poor outcomes in function and activity potentially contributing to reduced quality of life and increased hip fracture risk. INTRODUCTION: A significant increase in hip fracture incidence in the year following total knee replacement (TKR) surgery has been reported...
August 2016: Osteoporosis International
Mohammad Allahtavakoli, Najmeh Honari, Iran Pourabolli, Mohammad Kazemi Arababadi, Hossein Ghafarian, Ali Roohbakhsh, Ali Esmaeili Nadimi, Ali Shamsizadeh
INTRODUCTION: Lower level of estrogen hormone is considered as an important factor for loss of learning and memory in postmenopausal women. Although estrogen replacement therapy is used for compensation, but long-term usage of estrogen is associated with a higher risk of hormone-dependent cancers. Phytoestrogens, due to fewer side effects, have been proposed to prevent menopause-related cognitive decline. METHODS: 24 female Wistar rats weighing 180-220 g were used in this study...
July 2015: Basic and Clinical Neuroscience
Fei Li, Xiaolin Yang, Jianping Bi, Zhonglin Yang, Chunfeng Zhang
Context Eucommiae Cortex and Radix Dipsaci, occurring in a ratio of 1:1 in Du-Zhong-Wan (DZW), a Chinese herbal medicine, is available as a water extract followed by ethanol precipitation for the treatment of osteoporosis, fractures and menopausal syndrome. Objective This study investigates the protective effects of DZW in ovariectomy (OVX)-induced bone loss in a rat osteopenia model. Materials and methods Sixty Sprague-Dawley rats were randomly divided into the sham-operated group (SHAM) and five OVX subgroups: OVX with vehicle (OVX), 17β-estradiol (E2) and with three graded doses of DZW...
September 2016: Pharmaceutical Biology
Joan A Cebrick Grossman, Ellen K Payne
BACKGROUND: The mode and duration of exercise necessary to change body composition and reduce weight remains debatable. Menopause results in hormonal changes that preclude weight loss. This randomized pilot study compared the effects of short-duration, high-intensity interval training and traditional exercise on anthropometric and body composition measurement changes in post-menopausal women. OBJECTIVE: To compare the effects of short-duration, high-intensity interval training and traditional methods of exercise (walking) on anthropometric, body composition and body weight change over a 12-week period...
March 2016: Post Reproductive Health
Nicola Dalbeth, Gregory D Gamble, Anne Horne, Ian R Reid
In observational studies, serum urate concentrations associate with bone mineral density (BMD) and reduced risk of fractures. Thiazide diuretics slow the bone loss in healthy older adults, are associated with reduced incidence of fracture and also increase serum urate. We hypothesized that changes in serum urate are associated with changes in BMD during treatment with thiazide diuretics. We analysed data from a double-blind randomized controlled trial of hydrochlorothiazide (50 mg per day) and placebo in normal post-menopausal women...
May 2016: Calcified Tissue International
Cynthia L Bethea, Steven G Kohama, Arubala P Reddy, Henryk F Urbanski
With extended life spans in modern humans, menopause has become a significant risk factor for depression, anxiety, loss of cognitive functions, weight gain, metabolic disease, osteoporosis, cardiovascular disease, and neurodegenerative diseases. Clinical studies have found beneficial neural effects of ovarian steroid hormone therapy (HT) during the menopausal transition and data are emerging that it can be continued long term. To further understand molecular underpinnings of the clinical studies, we used quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) to examine gene expression in the serotonergic dorsal raphe of old (>18 years) rhesus macaques, focusing on genes related to depression, cellular resilience, and neurodegenerative diseases...
January 2016: Neurobiology of Aging
S L Goughnour, R C Thurston, A D Althouse, K E Freese, R P Edwards, G G Hamad, C McCloskey, R Ramanathan, D H Bovbjerg, F Linkov
OBJECTIVE: Menopausal symptoms are associated with a negative impact on the quality of life, leading women to seek medical treatment. Obesity has been linked to higher levels of menopausal symptoms such as hot flushes. This assessment will explore whether the prevalence and bother of hot flushes and vaginal dryness change from pre- to post-bariatric surgery among obese midlife women. METHODS: This study is a longitudinal analysis of data from 69 women (ages 35-72 years) undergoing bariatric surgery with reported reproductive histories and menopausal symptoms at preoperative and 6-month postoperative visits...
2016: Climacteric: the Journal of the International Menopause Society
C A Gonzales, P Bacchetti, M Khalili
Hepatitis C infection (HCV) and menopause are associated with insulin resistance (IR), and IR accelerates HCV-induced liver disease. The relationship between menopause and IR has not been studied in this population. This study aimed to assess the impact of menopause on IR and metabolic syndrome in HCV. One hundred and three (69 men, 16 premenopausal, 18 postmenopausal women) noncirrhotic, nondiabetic HCV-infected adults underwent IR measurement via steady-state plasma glucose during a 240-min insulin suppression test...
March 2016: Journal of Viral Hepatitis
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