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https://www.readbyqxmd.com/read/28441789/comparing-apoptosis-and-necrosis-effects-of-arctium-lappa-root-extract-and-doxorubicin-on-mcf7-and-mda-mb-231-cell-lines
#1
Fereshteh Ghafari, Mohammad Reza Rajabi, Tahereh Mazoochi, Mohsen Taghizadeh, Hossein Nikzad, Mohammad Ali Atlasi, Aliakbar Taherian
Objective: Breast cancer is a heterogeneous disease and very common malignancy in women worldwide. The efficacy of chemotherapy as an important part of breast cancer treatment is limited due to its side effects. While pharmaceutical companies are looking for better chemicals, research on traditional medicines that generally have fewer side effects is quite interesting. In this study, apoptosis and necrosis effect of Arctium lappa and doxorubicin was compared in MCF7, and MDA-MB-231 cell lines. Materials and Methods: MCF7 and MDA-MB-231 cells were cultured in RPMI 1640 containing 10% FBS and 100 U/ml penicillin/streptomycin...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28441741/peptides-peptidomimetics-and-polypeptides-from-marine-sources-a-wealth-of-natural-sources-for-pharmaceutical-applications
#2
Rushikesh Sable, Pravin Parajuli, Seetharama Jois
Nature provides a variety of peptides that are expressed in most living species. Evolutionary pressure and natural selection have created and optimized these peptides to bind to receptors with high affinity. Hence, natural resources provide an abundant chemical space to be explored in peptide-based drug discovery. Marine peptides can be extracted by simple solvent extraction techniques. The advancement of analytical techniques has made it possible to obtain pure peptides from natural resources. Extracted peptides have been evaluated as possible therapeutic agents for a wide range of diseases, including antibacterial, antifungal, antidiabetic and anticancer activity as well as cardiovascular and neurotoxin activity...
April 22, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28441593/a-comprehensive-evaluation-of-the-environmental-quality-of-a-coastal-lagoon-ravenna-italy-integrating-chemical-and-physiological-analyses-in-mussels-as-a-biomonitoring-strategy
#3
Marco Capolupo, Silvia Franzellitti, Alisar Kiwan, Paola Valbonesi, Enrico Dinelli, Emanuela Pignotti, Manfred Birke, Elena Fabbri
This study aimed at evaluating the environmental quality of a coastal lagoon (Pialassa Piomboni, NW-Adriatic, Italy) by combining analyses of biomarkers of environmental stress and bioaccumulation of contaminants in marine mussels (Mytilus galloprovincialis) transplanted for 28days to six selected sites. Assessed biomarkers encompassed lysosomal endpoints, oxidative stress and detoxification parameters, specific responses to metals, neuro- and genotoxic substances; chemical analyses focused on PAHs, metals, pesticide and pharmaceuticals...
April 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28441537/determination-of-dihydralazine-based-on-chemiluminescence-resonance-energy-transfer-of-hollow-carbon-nanodots
#4
Suqin Han, Zheyan Fan, Xiaoxia Chen, Yunfang Wu, Jianbo Wang
The famous weak chemiluminescence (CL) system of potassium permanganate and sodium bisulfite (KMnO4-HSO3(-)) was enhanced by the hollow fluorescent carbon nanodots (HCNs). The investigation of mechanism revealed that the enhanced CL was induced by the excited-state HCNs (HCNs(⁎)), which could be produced from the electron-transfer annihilation of positively charged HCNs (HCNs(+)) and negatively charged HCNs (HCNs(-)) as well as by CL resonance energy transfer (CRET) from excited SO2 (SO2(⁎))/(1)O2 to HCNs...
April 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28441497/development-of-a-biorelevant-material-sparing-membrane-flux-test-for-rapid-screening-of-bioavailability-enhancing-drug-product-formulations
#5
Aaron M Stewart, Michael E Grass, Deanna M Mudie, Michael M Morgen, Dwayne T Friesen, David T Vodak
Bioavailability-enhancing formulations are often used to overcome challenges of poor gastrointestinal solubility for drug substances developed for oral administration. Conventional in vitro dissolution tests often do not properly compare such formulations due to the many different drug species that may exist in solution. To overcome these limitations, we have designed a practical in vitro membrane flux test, requiring minimal active pharmaceutical ingredient (API) and capable of rapidly screening many drug product intermediates...
April 25, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28441448/development-and-validation-of-a-modified-korean-version-of-the-pharmacy-services-questionnaire-psq-k-for-the-quality-assessment-of-community-pharmacy-services
#6
Kyung Im Kim, Hae Sun Suh, Arim Kwak, Siin Kim, Nayoung Han, Euni Lee, Jung Mi Oh
Patient-reported outcome (PRO) measures and validated instruments have become integral in assessing the quality of healthcare delivery, including pharmaceutical care services. The Pharmacy Services Questionnaire (PSQ) measures patient satisfaction with pharmaceutical care. In this study, we developed a modified Korean version of the PSQ (PSQ-K) and evaluated its validity and reliability. The PSQ-K was developed using a strict translation and cultural-adaptation procedure. A validation study was performed in six community pharmacies in Korea...
2017: PloS One
https://www.readbyqxmd.com/read/28441154/clarifying-complex-inheritance-apolipoprotein-c3-and-atherosclerosis
#7
David J Galton
PURPOSE OF REVIEW: To describe some steps in the progress in the molecular biology of a peptide, apolipoprotein C3; its gene mutations that render individuals susceptible or resistant to developing hyperlipidaemia and atherosclerosis. RECENT FINDINGS: Data that lead to the development of a new therapeutic agent volanesorsen. SUMMARY: The agent blocks the function of the mRNA of apolipoprotein C3 and successfully treats severe hypertriglyceridaemia in phase 3 trials (Ionis Pharmaceuticals)...
April 22, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28440276/next-generation-probiotics-the-spectrum-from-probiotics-to-live-biotherapeutics
#8
Paul W O'Toole, Julian R Marchesi, Colin Hill
The leading probiotics currently available to consumers are generally drawn from a narrow range of organisms. Knowledge of the gut microbiota and its constituent actors is changing this paradigm, particularly given the phylogenetic range and relatively unknown characteristics of the organisms under investigation as novel therapeutics. For this reason, and because their development is likely to be more amenable to a pharmaceutical than a food delivery route, these organisms are often operationally referred to as next-generation probiotics, a concept that overlaps with the emerging concept of live biotherapeutic products...
April 25, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28439615/wip1-phosphatase-as-pharmacological-target-in-cancer-therapy
#9
REVIEW
Soňa Pecháčková, Kamila Burdová, Libor Macurek
DNA damage response (DDR) pathway protects cells from genome instability and prevents cancer development. Tumor suppressor p53 is a key molecule that interconnects DDR, cell cycle checkpoints, and cell fate decisions in the presence of genotoxic stress. Inactivating mutations in TP53 and other genes implicated in DDR potentiate cancer development and also influence the sensitivity of cancer cells to treatment. Protein phosphatase 2C delta (referred to as WIP1) is a negative regulator of DDR and has been proposed as potential pharmaceutical target...
April 24, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28439139/approvals-submission-and-important-labeling-changes-for-us-marketed-pharmaceuticals
#10
(no author information available yet)
This monthly feature will help readers keep current on new drug, new indications, dosage forms and safety-related changes in labeling or use. Efforts have been made to assure the accuracy of this information; however, if there are any questions, please let us know at jgeneral@ku.edu.
March 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28438697/predicting-drug-loading-in-pla-peg-nanoparticles
#11
M Meunier, A Goupil, P Lienard
Polymer nanoparticles present advantageous physical and biopharmaceutical properties as drug delivery systems compared to conventional liquid formulations. Active pharmaceutical ingredients (APIs) are often hydrophobic, thus not soluble in conventional liquid delivery. Encapsulating the drugs in polymer nanoparticles can improve their pharmacological and bio-distribution properties, preventing rapid clearance from the bloodstream. Such nanoparticles are commonly made of non-toxic amphiphilic self-assembling block copolymers where the core (poly-[D,L-lactic acid] or PLA) serves as a reservoir for the API and the external part (Poly-(Ethylene-Glycol) or PEG) serves as a stealth corona to avoid capture by macrophage...
April 21, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28438549/poly-methyl-vinyl-ether-co-maleic-acid-pectin-based-hydrogel-forming-systems-gel-film-and-microneedles
#12
Yusuf Kemal Demir, Ayşegül Ülkü Metin, Betül Şatıroğlu, Mehmet Ertuğrul Solmaz, Veysel Kayser, Karsten Mäder
Cross-linking of natural and synthetic polymers is widely explored to achieve the desired material properties (mechanical strength, drug loading capacity, swelling and erosion rates). However, the potential of polymers produced by crosslinking poly (methyl vinyl ether-co-maleic acid) (PMVE/MA) and pectin (PE) in pharmaceutics is mainly unexplored so far. We have investigated the effect of various esterification conditions and pectin content on the physicochemical properties. Materials have been characterized by fourier transform infrared, differential scanning calorimetry and scanning electron microscopy...
April 21, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28438231/health-technology-assessment-in-evaluation-of-pharmaceuticals-in-the-czech-republic
#13
Lenka Vostalová, Jana Mazelová, Jiří Samek, Milan Vocelka
OBJECTIVES: In the Czech Republic, the health technology assessment (HTA) approaches have been implemented in evaluation of medicinal products since 2008. The aim of this study was to provide an overview of the implementation of HTA and different levels thereof in the evaluation process conducted by the State Institute for Drug Control (SUKL) and to describe the impact of HTA on the entrance of new medicinal entities into out-patient healthcare system including highly innovative and orphan drugs...
April 25, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28438152/a-cluster-randomised-control-trial-to-evaluate-the-effectiveness-and-cost-effectiveness-of-the-italian-medicines-use-review-i-mur-for-asthma-patients
#14
Andrea Manfrin, Michela Tinelli, Trudy Thomas, Janet Krska
BACKGROUND: The economic burden of asthma, which relates to the degree of control, is €5 billion annually in Italy. Pharmacists could help improve asthma control, reducing this burden. This study aimed to evaluate the effectiveness and cost-effectiveness of Medicines Use Reviews provided by community pharmacists in asthma. METHODS: This cluster randomised, multi-centre, controlled trial in adult patients with asthma was conducted in 15 of the 20 regions of Italy between September 2014 and July 2015...
April 24, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28438049/ocular-non-p450-oxidative-reductive-hydrolytic-and-conjugative-drug-metabolizing-enzymes
#15
Upendra A Argikar, Jennifer L Dumouchel, Christine E Dunne, Andrea J Bushee
Metabolism in the eye for any species, laboratory animals or human, is gaining rapid interest as pharmaceutical scientists aim to treat a wide range of so-called incurable ocular diseases. Over a period of decades, reports of metabolic activity toward various drugs and biochemical markers have emerged in select ocular tissues of animals and humans. Ocular P450 enzymes and transporters have been recently reviewed. However, there is a dearth of collated information on non-P450 drug metabolizing enzymes in eyes of various preclinical species and humans in health and disease...
April 24, 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28437821/-rapid-cycling-in-bipolar-disorders-symptoms-%C3%A2-background%C3%A2-and-treatment-recommendations
#16
Stephan Köhler, Eva Friedel, Thomas Stamm
Rapid cycling bipolar disorder is encountered frequently in clinical practice with a lifetime prevalence of up to 31 %. Besides its association with greater illness severity, increased suicide and comorbidity rates, rapid cycling bipolar disorder has been closely associated with a longer and more complicated course of disease and inadequate treatment response compared to non-rapid cycling bipolar disorder. However rapid cycling does not serve as a stable characteristic of bipolar disorder, though its prevalence increases with illness duration...
April 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28437743/eco-pharmacovigilance-of-non-steroidal-anti-inflammatory-drugs-necessity-and-opportunities
#17
REVIEW
Bing-Shu He, Jun Wang, Juan Liu, Xia-Min Hu
Eco-pharmacovigilance (EPV) is a practical and powerful approach to minimize the potential risks posed by pharmaceutical residues in environment. However, it is impracticable to practise rigorous and unitary EPV process for all the existing and new pharmaceuticals. Here, we focused on non-steroidal anti-inflammatory drugs (NSAIDs), and discussed the necessity and potential opportunities of practising EPV of NSAIDs. We found that the consumption of NSAIDs is huge and ubiquitous across the globe. NSAIDs were worldwidely reported as one of the most dominant and frequently detected groups in environmental matrices including wastewater, surface water, suspended solids, sediments, groundwater, even drinking water...
April 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28437741/use-of-nuclear-receptor-luciferase-based-bioassays-to-detect-endocrine-active-chemicals-in-a-biosolids-biochar-amended-soil
#18
Carolyn G Anderson, Geetika Joshi, Daniel A Bair, Charlotte Oriol, Guochun He, Sanjai J Parikh, Michael S Denison, Kate M Scow
Biosolids are a potentially valuable source of carbon and nutrients for agricultural soils; however, potential unintended impacts on human health and the environment must be considered. Virtually all biosolids contain trace amounts endocrine-disrupting chemicals derived from human use of pharmaceuticals and personal care products (PPCPs). One potential way to reduce the bioavailability of PPCPs is to co-apply biosolids with biochar to soil, because biochar's chemical (e.g., aromaticity) and physical properties (e...
April 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28437738/simultaneous-spectrophotometric-determination-of-glimepiride-and-pioglitazone-in-binary-mixture-and-combined-dosage-form-using-chemometric-assisted-techniques
#19
Asmaa A El-Zaher, Ehab F Elkady, Hanan M Elwy, Mahmoud Abo El Makarim Saleh
In the present work, pioglitazone and glimepiride, 2 widely used antidiabetics, were simultaneously determined by a chemometric-assisted UV-spectrophotometric method which was applied to a binary synthetic mixture and a pharmaceutical preparation containing both drugs. Three chemometric techniques - Concentration residual augmented classical least-squares (CRACLS), principal component regression (PCR), and partial least-squares (PLS) were implemented by using the synthetic mixtures containing the two drugs in acetonitrile...
March 14, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28437649/occurrences-and-removal-of-pharmaceuticals-and-personal-care-products-ppcps-in-drinking-water-and-water-sewage-treatment-plants-a-review
#20
REVIEW
Yi Yang, Yong Sik Ok, Ki-Hyun Kim, Eilhann E Kwon, Yiu Fai Tsang
In recent years, many of micropollutants have been widely detected because of continuous input of pharmaceuticals and personal care products (PPCPs) into the environment and newly developed state-of-the-art analytical methods. PPCP residues are frequently detected in drinking water sources, sewage treatment plants (STPs), and water treatment plants (WTPs) due to their universal consumption, low human metabolic capability, and improper disposal. When partially metabolized PPCPs are transferred into STPs, they elicit negative effects on biological treatment processes; therefore, conventional STPs are insufficient when it comes to PPCP removal...
April 21, 2017: Science of the Total Environment
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