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https://www.readbyqxmd.com/read/29655502/effect-of-regional-cerebral-oximetry-to-estimate-neurologic-prognostic-outcomes-in-patients-administered-targeted-temperature-management
#1
Aykut Sarıtaş, Burcu Acar Çinleti, Çiler Zincircioğlu, Uğur Uzun, Işıl Köse, Nimet Şenoğlu
PURPOSE: The aim of our study is to research the role and efficacy of cerebral oximetry in predicting neurologic prognosis when applied during TTM to patients experiencing coma after CA. METHODS: This study was performed on surviving adult comatose patients after CA treated with TTM. The average scores of rSO2 was measured at 6h intervals for the first 2days and once a day for the following 3days with a NIRS device during TTM. The CPC scale was used to define the neurologic outcomes of patients...
April 9, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29652902/relations-between-right-ventricular-morphology-and-clinical-electrical-and-genetic-parameters-in-brugada-syndrome
#2
Belinda Gray, Ganesh Kumar Gnanappa, Richard D Bagnall, Giuseppe Femia, Laura Yeates, Jodie Ingles, Charlotte Burns, Rajesh Puranik, Stuart M Grieve, Christopher Semsarian, Raymond W Sy
BACKGROUND: Increasing evidence suggests the presence of structural changes affecting the right ventricular outflow tract (RVOT) in patients with Brugada Syndrome (BrS). The aim of this study was to characterise the RV morphology in BrS and explore associations between morphologic, clinical, electrical, and genetic parameters using non-invasive multimodality testing. METHODS: Consecutive BrS patients (recruited 2013-2015) underwent clinical assessment, dedicated RV imaging using cardiac magnetic resonance (CMR) imaging (unless contra-indicated), electrical assessment (electrocardiogram, Holter monitoring, signal-averaged ECG[SAECG]) and genotyping...
2018: PloS One
https://www.readbyqxmd.com/read/29652390/integrated-catheter-for-simultaneous-radio-frequency-ablation-and-optoacoustic-monitoring-of-lesion-progression
#3
Johannes Rebling, Francisco Javier Oyaga Landa, Xosé Luís Deán-Ben, Alexandre Douplik, Daniel Razansky
Radio frequency (RF) catheter ablation is commonly used to eliminate dysfunctional cardiac tissue by heating via an alternating current. Clinical outcomes are highly dependent on careful anatomical guidance, electrophysiological mapping, and careful RF power titration during the procedure. Yet, current treatments rely mainly on the expertise of the surgeon to assess lesion formation, causing large variabilities in the success rate. We present an integrated catheter design suitable for simultaneous RF ablation and real-time optoacoustic monitoring of the forming lesion...
April 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29652061/bevacizumab-and-near-infrared-probe-conjugated-iron-oxide-nanoparticles-for-vascular-endothelial-growth-factor-targeted-mr-and-optical-imaging
#4
Run Lin, Jing Huang, Liya Wang, Yuancheng Li, Malgorzata Lipowska, Hui Wu, Jianyong Yang, Hui Mao
Vascular endothelial growth factor (VEGF) plays a pivotal role in the cascade of development and progression of cancers. Targeting this cancer hallmark is a logical strategy for imaging based cancer detection and monitoring the anti-angiogenesis treatment. Using Bevacizumab (Avastin®), which is a recombinant humanized monoclonal antibody directly against VEGF and an angiogenesis inhibitor, as a targeting ligand, a multimodal VEGF targeted molecular imaging probe was developed by conjugating near infrared dye (NIR830) labeled bevacizumab to magnetic iron oxide nanoparticles (IONP) for optical and magnetic resonance (MR) imaging of cancers over-expressing VEGF...
April 13, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29628836/morphine-versus-fentanyl-patient-controlled-analgesia-for-postoperative-pain-control-in-major-hepatic-resection-surgeries-including-living-liver-donors-a-retrospective-study
#5
Eman M Nada, Abdulmajeed Alabdulkareem
Background: Liver resection surgery results in significant postoperative pain. However, it is still not clear which opioids used by patient-controlled analgesia (PCA) provides the best pain control and results in the least side effect in a patient with impaired liver function. Our hypothesis was that fentanyl is a better choice than morphine as it is a potent analgesic that its elimination half-life does not depend on the hepatic uptake and metabolism. The Study Purpose: Is to compare morphine and fentanyl PCA in liver resection patients as regards the degree of pain control, the consumption of opioids, and the side effects...
April 2018: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29623667/a-review-of-the-opioid-epidemic-what-do-we-do-about-it
#6
REVIEW
Edward A Shipton, Elspeth E Shipton, Ashleigh J Shipton
The opioid epidemic, with its noticeable increase in opioid prescriptions and related misuse, abuse and resultant deaths in the previous 12 years, is a particularly North American phenomenon. Europe, and particularly low- and middle-income countries, appear to be less influenced by this problem. There is undisputable value in using opioids not only in the treatment of acute pain, but in cancer pain as well. However, opioids are progressively being prescribed more and more for chronic non-cancer pain, despite inadequate data on their efficacy...
April 6, 2018: Pain and Therapy
https://www.readbyqxmd.com/read/29621117/cerebral-multimodal-monitoring-in-sepsis-an-experimental-study
#7
Pedro Kurtz, Joana C d'Avila, Darwin Prado, Caroline Madeira, Charles Vargas-Lopes, Rogerio Panizzutti, Luciano Cesar Pontes Azevedo, Fernando A Bozza
Acute brain dysfunction is a complication of sepsis and its pathophysiology remains poorly understood. We studied the brain metabolism in a resuscitated animal model of sepsis. Twelve anesthetized, mechanically ventilated and invasively monitored pigs were allocated to a sham procedure (N = 5) or sepsis (N = 7). Sepsis was induced through fecal inoculation in the peritoneum. Fluid resuscitation was maintained during the entire study period. Animals were observed until spontaneous death or for a maximum of 24 hours...
April 4, 2018: Shock
https://www.readbyqxmd.com/read/29620367/structural-mechanical-imaging-and-in-vitro-evaluation-of-the-combined-effect-of-gd-3-and-dy-3-in-the-zro-2-sio-2-binary-system
#8
S Vasanthavel, Sharad Awasthi, Arunkumar Dhayalan, Brian Derby, S Kannan
Mechanical strength and biocompatibility are considered the main prerequisites for materials in total hip replacement or joint prosthesis. Noninvasive surgical procedures are necessary to monitor the performance of a medical device in vivo after implantation. To this aim, simultaneous Gd3+ and Dy3+ additions to the ZrO2 -SiO2 binary system were investigated. The results demonstrate the effective role of Gd3+ and Dy3+ to maintain the structural and mechanical stability of cubic zirconia ( c-ZrO2 ) up to 1400 °C, through their occupancy of ZrO2 lattice sites...
April 5, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29615099/multimodal-label-free-imaging-of-living-dermal-equivalents-including-dermal-papilla-cells
#9
Aleksandra V Meleshina, Olga S Rogovaya, Varvara V Dudenkova, Marina A Sirotkina, Maria M Lukina, Alena S Bystrova, Victoria G Krut, Daria S Kuznetsova, Ekaterina P Kalabusheva, Andrey V Vasiliev, Ekaterina A Vorotelyak, Elena V Zagaynova
BACKGROUND: Despite the significant progress in the development of skin equivalents (SEs), the problem of noninvasively assessing the quality of the cell components and the collagen structure of living SEs both before and after transplantation remains. Undoubted preference is given to in vivo methods of noninvasive, label-free monitoring of the state of the SEs. Optical bioimaging methods, such as cross-polarization optical coherence tomography (CP OCT), multiphoton tomography (MPT), and fluorescence lifetime imaging microscopy (FLIM), present particular advantages for the visualization of such SEs...
April 3, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29614675/the-vascular-hypothesis-of-alzheimer-s-disease-a-key-to-preclinical-prediction-of-dementia-using-neuroimaging
#10
Jack de la Torre
The vascular hypothesis of Alzheimer's disease (VHAD) was proposed 24 years ago from observations made in our laboratory using aging rats subjected to chronic brain hypoperfusion. In recent years, VHAD has become a mother-lode to numerous neuroimaging studies targeting cerebral hemodynamic changes, particularly brain hypoperfusion in elderly patients at risk of developing Alzheimer's disease (AD). There is a growing consensus among neuroradiologists that brain hypoperfusion is likely involved in the pathogenesis of AD and that disturbed cerebral blood flow (CBF) can serve as a key biomarker for predicting conversion of mild cognitive impairment to AD...
March 29, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29609357/implementation-of-a-violet-scheimpflug-lidar-system-for-atmospheric-aerosol-studies
#11
Liang Mei, Zheng Kong, Peng Guan
A violet Scheimpflug lidar system employing a 1-W 407-nm multimode laser diode is developed for remote sensing of atmospheric aerosols. The laser beam of the laser diode that is transmitted into atmosphere has been investigated in detail and a cylindrical lens pair is designed to improve the geometrical transmission efficiency. A measurement scheme with automatic exposure as well as a generalized signal processing method are established to optimize the signal-to-noise ratio of lidar signals. The performance of the violet Scheimpflug lidar system has been evaluated during a six-day continuous measurement campaign on a near horizontal path...
March 19, 2018: Optics Express
https://www.readbyqxmd.com/read/29606873/noninvasive-evaluation-of-the-migration-effect-of-transplanted-endothelial-progenitor-cells-in-ischemic-muscle-using-a-multimodal-imaging-agent
#12
Xingui Peng, Cong Li, Yingying Bai, Xinyi Wang, Yi Zhang, Yanli An, Gao-Jun Teng, Shenghong Ju
Background: Endothelial progenitor cells (EPCs) play an important role in repairing ischemia tissues. However, the survival, migration and therapeutic efficacy of EPCs after transplantation need to be better understood for further cell therapy. Purpose: This study investigated the migration effect of EPCs labeled with a multimodal imaging agent in a murine ischemic hindlimb model, using magnetic resonance imaging (MRI) and optical imaging after transplantation. Methods: EPCs derived from mouse bone marrow were labeled with a multimodal imaging agent and were administered through intracardiac delivery to mice with ischemic hindlimbs...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29606335/spinal-manipulative-therapy-and-other-conservative-treatments-for-low-back-pain-a-guideline-from-the-canadian-chiropractic-guideline-initiative
#13
André E Bussières, Gregory Stewart, Fadi Al-Zoubi, Philip Decina, Martin Descarreaux, Danielle Haskett, Cesar Hincapié, Isabelle Pagé, Steven Passmore, John Srbely, Maja Stupar, Joel Weisberg, Joseph Ornelas
OBJECTIVE: The objective of this study was to develop a clinical practice guideline on the management of acute and chronic low back pain (LBP) in adults. The aim was to develop a guideline to provide best practice recommendations on the initial assessment and monitoring of people with low back pain and address the use of spinal manipulation therapy (SMT) compared with other commonly used conservative treatments. METHODS: The topic areas were chosen based on an Agency for Healthcare Research and Quality comparative effectiveness review, specific to spinal manipulation as a nonpharmacological intervention...
March 29, 2018: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29588255/tumor-targeting-cus-nanoparticles-for-multimodality-imaging-and-guided-photothermal-therapy-of-lymph-node-metastasis
#14
Hua Shi, Runqi Yan, Luyan Wu, Yidan Sun, Song Liu, Zhengyang Zhou, Jian He, Deju Ye
Precise diagnosis of lymph node metastasis to guide lymphadenectomy is highly important for gastric cancer therapy in clinics. Though surgical dissection of regional metastatic lymph nodes remains the only way for gastric cancer therapy, the extended dissection may cause unavoidable postoperative risk of complications. These is still lack of effective method enabling the accurate removal of metastatic gastric cancer cells in lymph nodes with minimum injuries to normal tissue. Herein, we report a new fluorescent copper sulfide (CuS) nanoparticle (RGD-CuS-Cy5...
March 24, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29581794/noninvasive-glioblastoma-testing-multimodal-approach-to-monitoring-and-predicting-treatment-response
#15
REVIEW
Maikel Verduin, Inge Compter, Danny Steijvers, Alida A Postma, Daniëlle B P Eekers, Monique M Anten, Linda Ackermans, Mark Ter Laan, Ralph T H Leijenaar, Tineke van de Weijer, Vivianne C G Tjan-Heijnen, Ann Hoeben, Marc Vooijs
Glioblastoma is the most aggressive adult primary brain tumor which is incurable despite intensive multimodal treatment. Inter- and intratumoral heterogeneity poses one of the biggest barriers in the diagnosis and treatment of glioblastoma, causing differences in treatment response and outcome. Noninvasive prognostic and predictive tests are highly needed to complement the current armamentarium. Noninvasive testing of glioblastoma uses multiple techniques that can capture the heterogeneity of glioblastoma. This set of diagnostic approaches comprises advanced MRI techniques, nuclear imaging, liquid biopsy, and new integrated approaches including radiogenomics and radiomics...
2018: Disease Markers
https://www.readbyqxmd.com/read/29579815/utility-of-transcranial-doppler-in-the-coordination-of-transplants-10-years-of-experience
#16
A Cacciatori, M Godino, R Mizraji
Transcranial Doppler (TCD) integrated to multimodal neuromonitoring of neurocritical patients is a useful tool in the clinical follow-up. A retrospective and descriptive study of 194 patients who were admitted into the intensive care unit (ICU) was carried out from December 2007 to February 2017. We analyzed the distribution of study frequencies with respect to the pathologies that motivated them, the characteristics of patients who evolved to brain death (BD), and most frequent patterns of cerebral circulatory arrest...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29574587/can-nuclear-imaging-techniques-predict-patient-outcome-and-guide-medical-management-in-hereditary-transthyretin-cardiac-amyloidosis
#17
REVIEW
Vincent Algalarrondo, Eve Piekarski, Ludivine Eliahou, Dominique Le Guludec, Michel S Slama, François Rouzet
PURPOSE OF REVIEW: Nuclear imaging recently gained a key role in the diagnosis and prognostic assessment of transthyretin (TTR)-related cardiac amyloidosis. This review aims at summarizing the state-of-the art regarding the implementation of nuclear imaging in the management of hereditary mutated TTR-cardiac amyloidosis (mTTR-CA). RECENT FINDINGS: Although cardiac uptake of bone tracers is acknowledged as a specific marker of TTR amyloid cardiac burden, recent studies validated the implementation of bone scan in the flow chart for non-invasive diagnosis and follow-up of CA in multicenter trials...
March 24, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29573263/effect-of-pre-operative-methylprednisolone-on-orthostatic-hypotension-during-early-mobilization-after-total-hip-arthroplasty
#18
V Lindberg-Larsen, P B Petersen, Ø Jans, T Beck, H Kehlet
BACKGROUND: Orthostatic hypotension (OH) and intolerance (OI) are common after total hip arthroplasty (THA) and may delay early mobilization. The pathology of OH and OI includes a dysregulated post-operative vasopressor response, by a hitherto unknown mechanism. We hypothesized that OI could be related to the inflammatory stress response which is inhibited by steroid administration. Consequently, this study evaluated the effect of a pre-operative high-dose methylprednisolone on OH and OI early after THA...
March 24, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29559781/novel-treatment-options-in-depression-and-psychosis
#19
REVIEW
Eva Ceskova, Petr Silhan
In spite of tremendous development in central nervous system research, current treatment is suboptimal, especially in severe mental disorders. In medicine, there are two main methods of improving the health care provided: seeking new treatment procedures and perfecting (optimizing) the existing ones. Optimization of treatment includes not only practical tools such as therapeutic drug monitoring but also implementation of general trends in the clinical practice. New pharmacological options include new more sophisticated forms of monoaminergic drugs, old drugs rediscovered on the base of a better understanding of pathophysiology of mental illnesses, and drugs aimed at new treatment targets...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29554362/screening-for-idiopathic-rem-sleep-behavior-disorder-usefulness-of-actigraphy
#20
A Stefani, A Heidbreder, E Brandauer, M Guaita, L M Neier, T Mitterling, J Santamaria, A Iranzo, A Videnovic, C Trenkwalder, F Sixel-Döring, G K Wenning, A Chade, W Poewe, O S Gershanik, B Högl
Study objective: To evaluate the utility of multimodal low-cost approaches including actigraphy, a wrist-worn device monitoring rest/activity cycles, in identifying patients with idiopathic REM sleep behavior disorder (iRBD). Methods: Seventy patients diagnosed with sleep disorders causing different motor manifestations during sleep (iRBD, sleep apnea, restless legs syndrome) and 20 subjects without any relevant motor manifestation during sleep, underwent video-polysomnography (vPSG) and two-week actigraphy, completed six validated RBD screening questionnaires, and sleep apps use was assessed...
March 15, 2018: Sleep
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