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https://www.readbyqxmd.com/read/28432709/a-new-modality-for-the-estimation-of-corrected-flow-time-via-electrocardiography-as-an-alternative-to-doppler-ultrasonography
#1
Hooman Hossein-Nejad, Payam Mohammadinejad, Atefeh Zeinoddini, Seyedhossein Seyedhosseini Davarani, Mohsen Banaie
BACKGROUND: Evaluation of corrected flow time (FTc) via ultrasonography is one of the suggested modalities for the assessment of intravascular volume status. This study aimed to compare the results of FTc of carotid artery measured via ultrasonography, as a measure of mechanical outcome of the cardiac cycle, with the results of FTc estimation from a new modified formula via electrocardiography (ECG), as a measure of electrical function of the cardiac cycle. METHODS: Healthy volunteers were evaluated before and after a passive leg raising (PLR) maneuver...
April 22, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28432136/selective-modulation-of-the-pupil-light-reflex-by-prefrontal-cortex-microstimulation
#2
R Becket Ebitz, Tirin Moore
The prefrontal cortex (PFC) is thought to flexibly regulate sensorimotor responses. One way the PFC regulates sensorimotor transformations is to modulate activity in other circuits. However, the scope of that control remains unknown: it remains unclear whether the prefrontal cortex can modulate basic reflexes. One canonical example of a central reflex is the pupil light reflex (PLR): the automatic constriction of the pupil in response to luminance increments. Unlike pupil size, which depends the interaction of multiple physiological and neuromodulatory influences, the PLR reflects the action of a simple brainstem circuit...
April 21, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28431566/the-prognostic-value-of-the-preoperative-c-reactive-protein-albumin-ratio-in-ovarian-cancer
#3
Yubo Liu, Shengfu Chen, Chengyu Zheng, Miao Ding, Lan Zhang, Liangan Wang, Meiqing Xie, Jianhua Zhou
BACKGROUND: Inflammation plays an important role in the pathogenesis of ovarian cancer. This study sought to investigate the association between the preoperative c-reactive protein/albumin ratio (CRP/Alb) and oncological outcomes in ovarian cancer patients. METHODS: Two hundred patients with histologically verified ovarian cancer between June 2006 and July 2012 were retrospectively reviewed. Overall survival was evaluated by the Kaplan-Meier method and log-rank test...
April 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28427174/association-of-immunologic-markers-from-complete-blood-counts-with-the-response-to-preoperative-chemoradiotherapy-and-prognosis-in-locally-advanced-rectal-cancer
#4
Sung Woo Jung, In Ja Park, Se Heon Oh, Seung-Seop Yeom, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, Seok-Byung Lim, Jung Bok Lee, Chang Sik Yu, Jin Cheon Kim
We investigated retrospectively whether immunologic markers from a complete blood count (CBC) are associated with the responsiveness to preoperative chemoradiotherapy (PCRT) and oncologic outcomes in 984 patients with locally advanced rectal cancer (LARC) who also underwent radical surgery from 2005 to 2013. CBC parameters including the neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) were recorded. Pathologic responses to PCRT were evaluated in the resected specimens using the tumor regression grade system...
February 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423876/effects-of-confinement-on-physiological-and-psychological-response-and-expression-of-il-6-and-bdnf-mrna-in-primiparous-and-multiparous-weaning-sows
#5
Mingyue Zhang, Xiang Li, Jianhong Li, Hanqing Sun, Xiaohui Zhang, Jun Bao
Objective: The present study aimed to investigate whether the long-lasting, recurrent restricting of sows leads to the physiological and psychological reaction of discomfort. Methods: Sows (Large White) that had experienced restricting for about 0.5 or 3 years and age-matched sows kept in a group housing system (loose sows) were compared. PLR parameters were measured at the weaning stage. Immediately after slaughter, blood samples were taken to measure serum cortisol levels, and the brain was dissected, gene expression in the hippocampus, frontal cortex and hypothalamus was analyzed...
March 25, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28423566/the-diagnostic-role-of-microrna-34a-in-breast-cancer-a-systematic-review-and-meta-analysis
#6
Saber Imani, Xianqin Zhang, Hossein Hosseinifard, Shangyi Fu, Junjiang Fu
BACKGROUND: MicroRNA-34a (miR-34a) is a master regulator of tumor suppression in breast cancer (BC). This systematic review aims to analyze the diagnostic accuracy of miR-34a in the detection of BC as a biomarker. RESULTS: A total of 1858 BC cases and 494 controls from thirteen eligible studies reported in 9 publications were included. The overall pooled sensitivity, specificity, negative likelihood ratio (NLR), positive likelihood ratio (PLR), and diagnostic odds ratio (DOR) were 85...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28421205/the-preferential-impairment-of-pupil-constriction-stimulated-by-blue-light-in-patients-with-type-2-diabetes-without-autonomic-neuropathy
#7
Fukashi Ishibashi, Rie Kojima, Miki Taniguchi, Aiko Kosaka, Harumi Uetake, Mitra Tavakoli
The main aim of the present paper is to examine whether the pupillary light reflex (PLR) mediated by intrinsically photosensitive retinal ganglion cells (ipRGCs) is impaired in type 2 diabetic patients. One hundred and three diabetic patients without diabetic autonomic neuropathy (DAN) and 42 age-matched controls underwent a series of detailed neurological examinations. The patients were stratified into three groups: stage I, no neuropathy; stage II, asymptomatic neuropathy; stage III, symptomatic but without DAN...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28420471/-mixed-venous-arterial-carbon-dioxide-difference-combined-with-passive-leg-raising-in-guiding-volume-management-for-patients-post-off-pump-coronary-artery-bypass-grafting
#8
Likun Huo, Peijun Li, Chang Xie, Chenglei Yan, Jie Li
OBJECTIVE: To investigate whether mixed venous-arterial carbon dioxide difference (Pv-aCO2) combined with passive leg raising (PLR) could better guide volume management for patients post off-pump coronary artery bypass grafting (OPCABG). METHODS: Eighty patients experienced OPCABG, and admitted to Tianjin Chest Hospital from June 1st to October 1st in 2016 were enrolled. They were randomly divided into two groups: observation group given Pv-aCO2 combined with PLR directed therapy and control group given central venous pressure (CVP) directed therapy, 40 cases in each group...
April 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28418850/the-prognostic-value-of-preoperative-neutrophils-platelets-lymphocytes-monocytes-and-calculated-ratios-in-patients-with-laryngeal-squamous-cell-cancer
#9
Chiyao Hsueh, Lei Tao, Ming Zhang, Wenjun Cao, Hongli Gong, Jian Zhou, Liang Zhou
This study was aimed to examine the prognostic value of preoperative neutrophils, platelets, lymphocytes, monocytes and calculated ratios in patients with laryngeal squamous cell cancer (LSCC). From January 2007 to December 2011, 979 patients with LSCC were enrolled in our study. Preoperative neutrophils, platelets, lymphocytes, monocytes, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) were analyzed. Besides well-established clinicopathological prognostic factors, we evaluated the independent prognostic relevance of these hematological parameters by Cox regression models in disease-free survival (DFS) and cancer-specific survival (CSS)...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415658/diagnostic-and-prognostic-value-of-blood-samples-for-kras-mutation-identification-in-lung-cancer-a-meta-analysis
#10
REVIEW
Hongchang Shen, Keying Che, Lei Cong, Wei Dong, Tiehong Zhang, Qi Liu, Jiajun Du
Circulating tumor DNA (ctDNA) and tumor cells (CTC) are novel approaches for identifying genomic alterations. Thus, we designed a meta-analysis to evaluate the diagnostic value and prognostic significance of a KRAS proto-oncogene, GTPase (KRAS) mutation for lung cancer patients. All included articles were from PubMed, EMBASE, Web of Science and Cochrane Library. Twelve articles that described 1,131 patients were reviewed. True positives (TP), false positives (FP), true negatives (TN), and false negatives (FN) were used to calculate pooled sensitivity, specificity, the positive likelihood ratio (PLR), the negative likelihood ratio (NLR), a diagnostic odds ratio (DOR), the area under the curve (AUC) and corresponding 95% confidence intervals (95% CI)...
March 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414120/the-predictive-value-of-integrated-inflammation-scores-on-survival-of-patients-with-resected-hepatocellular-carcinoma
#11
Shuo Pang, Ziquan Zhou, Xingchen Yu, Shaozhong Wei, Qiongrong Chen, Shaofa Nie, Xinjun Liang, Li Liu
BACKGROUND: Evidence supports the predictive potential of inflammatory marker-derived scores (inflammation scores) and hepatitis B virus (HBV) infection on prognosis of patients with hepatocellular carcinoma (HCC). However, no study has longitudinally assessed the predictive values of inflammation scores combined with hepatitis B virus status on survival of these patients. Therefore, a study was designed to evaluate the prognostic capacity of preoperative, dynamic changes in integrated scores, through a combination of general inflammation scores and HBV infection status, on HCC patients undergoing tumor resection...
April 13, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28413722/performance-of-interferon-%C3%AE-release-assay-in-the-diagnosis-of-tuberculous-lymphadenitis-a-meta-analysis
#12
Qianqian Liu, Wenzhang Li, Yunfeng Chen, Xinmiao Du, Chengdi Wang, Binmiao Liang, Yin Tang, Yulin Feng, Chuanmin Tao, Jian-Qing He
BACKGROUND: The diagnostic values of interferon-gamma release assays (IGRA) in tuberculosis (TB) vary a lot with different site of infections, with especially higher sensitivities in chronic forms of TB such as tuberculosis of the lymph node. We conducted a meta-analysis to comprehensively evaluate the overall accuracy of diagnostic IGRA for tuberculous lymphadenitis. METHODS: Pubmed, Web of Science, EMBASE, Wanfang and CNKI databases up to February 17, 2017 were searched to identify published studies...
2017: PeerJ
https://www.readbyqxmd.com/read/28412759/preoperative-monocyte-lymphocyte-and-neutrophil-lymphocyte-but-not-platelet-lymphocyte-ratios-are-predictive-of-clinical-outcomes-in-resected-patients-with-non-metastatic-siewert-type-ii-iii-adenocarcinoma-of-esophagogastric-junction-a-prospective-cohort-study
#13
Jia-Wei Zhang, Lei Huang, A-Man Xu
AIMS: To propectively reveal the clinicopathological and prognostic significances of monocyte-lymphocyte ratio (MLR), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in resected patients with non-metastatic Siewert type II/III adenocarcinoma of esophagogastric junction (AEG). METHODS: A total of 611 patients diagnosed with Siewert type II/III AEG and undergoing surgery between 2006 and 2011 were prospectively followed-up until April 2016. Associations between preoperative peripheral MLR, NLR, and PLR and clinicopathological parameters were quantified using the multivariate Logistic regression model with adjustment...
February 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412137/are-markers-of-systemic-inflammation-good-prognostic-indicators-in-colorectal-cancer
#14
REVIEW
Sabrina Rossi, Michele Basso, Antonia Strippoli, Giovanni Schinzari, Ettore D'Argento, Mario Larocca, Alessandra Cassano, Carlo Barone
Systemic inflammation has been proved to play a crucial role in promoting cancer progression and metastasis in many cancer types, including colorectal cancer (CRC). The aim of the present review was to provide an overview of studies regarding the prognostic value of inflammation-based markers in patients with CRC. A literature search was performed for articles reporting the prognostic value of the Glasgow prognostic score (GPS), modified GPS (mGPS), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) in relation to CRC outcomes...
March 24, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28407827/-values-of-neutrophil-lymphocyte-ratio-and-platelet-lymphocyte-ratio-in-predicting-sensitivity-to-intravenous-immunoglobulin-in-kawasaki-disease
#15
Ying-Di Yuan, Jun Sun, Peng-Fei Li, Chun-Lei Wei, Yan-Hui Yu
OBJECTIVE: To study the values of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in predicting the sensitivity to intravenous immunoglobulin (IVIG) in Kawasaki disease (KD). METHODS: A retrospective cohort study was conducted in 404 children with newly diagnosed KD. The data on routine blood tests, NLR, and PLR were collected before and after IVIG treatment. The receiver operating characteristic (ROC) curve was used to determine the cut-off values of NLR and PLR in predicting the insensitivity to IVIG...
April 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28404961/increased-platelet-lymphocyte-ratio-closely-relates-to-inferior-clinical-features-and-worse-long-term-survival-in-both-resected-and-metastatic-colorectal-cancer-an-updated-systematic-review-and-meta-analysis-of-24-studies
#16
Nan Chen, Wanling Li, Kexin Huang, Wenhao Yang, Lin Huang, Tianxin Cong, Qingfang Li, Meng Qiu
Colorectal cancer (CRC) is one of the most common cancers worldwide. However, the prognostic and clinical value of platelet-lymphocyte ratio (PLR) in colorectal cancer was still unclear, which attracted more and more researchers' considerable attention. We performed a systematic review and meta-analysis to investigate the relationship between PLR and survival as well as clinical features of CRC update to September 2016. The hazard ratio (HR) or odds ratio (OR) with 95% confidence interval (CI) were calculated to access the association...
March 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28404921/circulating-mir-31-as-an-effective-biomarker-for-detection-and-prognosis-of-human-cancer-a-meta-analysis
#17
Yingjun Ma, Yunfang Chen, Jinbo Lin, Yi Liu, Kai Luo, Yong Cao, Tieqiang Wang, Hongwei Jin, Zhan Su, Haolin Wu, Xiaoliang Chen, Jinquan Cheng
PURPOSE: Circulating miR-31 was found to be associated with cancers detection and prognosis. The present meta-analysis aimed to explore the effect of circulating miR-31 on cancer detection and prognosis. METHOD: The studies were accessed using multiple databases. RevMan5.3, Meta-DiSc 1.4, and STATA14.0 were used to estimate the pooled effects, heterogeneity among studies, and publication bias. RESULTS: A total of 14 studies with 1397 cancer patients and 1039 controls were included...
February 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28394979/-validity-of-three-methods-for-inmuno-diagnostic-of-neurocysticercosis-systematic-review-of-the-literature-with-meta-analysis-1960-2014
#18
Jaiberth Antonio Cardona-Arias, Yoneida Elena Carrasquilla-Agudelo, Deisy Cristina Restrepo-Posada
INTRODUCTION: The screening of neurocysticercosis is complex and immunological methods have varying validity. OBJECTIVE: To evaluate the validity of ELISA for antigen and antibody, and EITB for antibody in the screening of neurocysticercosis. METHODS: Meta-analysis of diagnostic tests with an ex-ante protocol implemented in five databases with 15 search strategies, ensuring reproducibility in the selection and extraction of information. Sensitivity, specificity, likelihood ratios (LR), diagnostic odds ratio and ROC curve were estimated in MetaDiSc, and predictive values, and Youden index were estimated in Epidat...
February 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28394006/prognostic-value-of-platelet-to-lymphocyte-ratio-in-acute-coronary-syndrome-a-systematic-review-and-meta-analysis
#19
Li Hui, Yun Zhou, Yan Ma, Su Xia Han, Lian Suo Zhou
BACKGROUND: The aim of this study was to investigate whether the platelet-to-lymphocyte ratio (PLR) is an independent predictor of all-cause mortality and cardiovascular events in patients with acute coronary syndrome (ACS). METHODS: PubMed, Embase, and the Cochrane Library were searched for relevant cohort studies regarding the association between PLR and outcomes of patients with ACS. Either a random- or a fixed-effect model was used for pooling data. RESULTS: Eight studies involving 6627 patients with ACS were included...
April 10, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28392852/a-systematic-review-and-meta-analysis-of-c-arm-cone-beam-ct-guided-percutaneous-transthoracic-needle-biopsy-of-lung-nodules
#20
Gao-Wu Yan, Anup Bhetuwal, Gao-Wen Yan, Qin-Quan Sun, Xiang-Ke Niu, Yu Zhou, Li-Fa Li, Bin-Zhong Li, Hao Zeng, Chuan Zhang, Bing Li, Xiao-Xue Xu, Han-Feng Yang, Yong Du
BACKGROUND: A systematic review and meta-analysis of all available publications was performed to evaluate the diagnostic accuracy of percutaneous transthoracic needle biopsy (PTNB) using a C-Arm Cone-Beam CT (CBCT) system in patients with lung nodules. MATERIAL/METHODS: Thedatabases of PUBMED, OVID, EBSCO, EMBASE, and China National Knowledge Infrastructure (CNKI) were systematically searched for relevant original articles on the diagnostic accuracy of CBCT-guided PTNB for the diagnosis of nodules in the lungs...
2017: Polish Journal of Radiology
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