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https://www.readbyqxmd.com/read/28333846/prognostic-value-of-fluorine-18-fluorodeoxyglucose-uptake-of-bone-marrow-on-positron-emission-tomography-computed-tomography-for-prediction-of-disease-progression-in-cervical-cancer
#1
Jeong Won Lee, Seob Jeon, Seong Taek Mun, Sang Mi Lee
OBJECTIVE: This study aimed to evaluate the prognostic value of fluorine-18 fluorodeoxyglucose (FDG) uptake of bone marrow (BM) on positron emission tomography (PET)/computed tomography in patients with uterine cervical cancer. METHODS: One hundred forty-five patients with cervical cancer who underwent staging FDG PET/computed tomography and subsequent surgical resection or chemoradiotherapy were retrospectively enrolled in the study. Mean BM FDG uptake (BM standardized uptake value [SUV]) and BM-to-liver uptake ratio of FDG uptake (BLR) were measured...
March 23, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28332564/pupillary-responses-in-non-proliferative-diabetic-retinopathy
#2
Jason C Park, Yi-Fan Chen, Norman P Blair, Felix Y Chau, Jennifer I Lim, Yannek I Leiderman, Mahnaz Shahidi, J Jason McAnany
The goal of this study was to determine the extent of rod-, cone-, and melanopsin-mediated pupillary light reflex (PLR) abnormalities in diabetic patients who have non-proliferative diabetic retinopathy (NPDR). Fifty diabetic subjects who have different stages of NPDR and 25 age-equivalent, non-diabetic controls participated. PLRs were measured in response to full-field, brief-flash stimuli under conditions that target the rod, cone, and intrinsically-photosensitive (melanopsin) retinal ganglion cell pathways...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327834/-performance-of-cognitive-brief-test-in-elderly-patients-with-dementia-in-advanced-stage-living-in-an-urban-community-of-lima-peru
#3
Nilton Custodio, Carlos Alva-Diaz, Yahaira Becerra-Becerra, Rosa Montesinos, David Lira, Eder Herrera-Pérez, Sheila Castro-Suárez, José Cuenca-Alfaro, Elizabeth Valeriano-Lorenzo
Objectives.: Evaluate the performance of clock drawing test- Manos versión (PDR-M) and Mini Mental State Examination -Peruvian version (MMSE) to detect dementia in a sample based on urban community of Lima, Peru. Materials and methods.: This study is a secondary analysis database, observational, analytical and cross-sectional, the gold standard was the clinical and the neuropsychological evaluations together. Performance testing individually and in combination were evaluated...
October 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28326023/infrared-video-pupillography-coupled-with-smart-phone-led-for-measurement-of-pupillary-light-reflex
#4
Lily Yu-Li Chang, Jason Turuwhenua, Tian Yuan Qu, Joanna M Black, Monica L Acosta
Clinical assessment of pupil appearance and pupillary light reflex (PLR) may inform us the integrity of the autonomic nervous system (ANS). Current clinical pupil assessment is limited to qualitative examination, and relies on clinical judgment. Infrared (IR) video pupillography combined with image processing software offer the possibility of recording quantitative parameters. In this study we describe an IR video pupillography set-up intended for human and animal testing. As part of the validation, resting pupil diameter was measured in human subjects using the NeurOptics(™) (Irvine, CA, USA) pupillometer, to compare against that measured by our IR video pupillography set-up, and PLR was assessed in guinea pigs...
2017: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/28324786/assessment-of-corrected-flow-time-in-carotid-artery-via-point-of-care-ultrasonography-reference-values-and-the-influential-factors
#5
Hooman Hossein-Nejad, Mohsen Banaie, Seyedhossein Seyedhosseini Davarani, Payam Mohammadinejad
OBJECTIVE: Assessment of Corrected Flow Time (FTc) in carotid artery has been suggested recently as a measure of intravascular volume status. This study aimed to determine the reference values of FTc in carotid artery in a normal population. METHODS: A total number of 142 healthy volunteers (73 females and 69 males) with a mean age of 36.65±10.52years were included. RESULTS: The mean FTc in carotid artery was 325.18±22.15ms(0.5). The mean value of FTc differed significantly between females and males both before and after passive leg raise (PLR) (330...
March 14, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28323719/passive-leg-raising-for-assessment-of-volume-responsiveness-a-review
#6
Jaume Mesquida, Guillem Gruartmoner, Ricard Ferrer
PURPOSE OF REVIEW: To evaluate the existing evidence on the passive leg raising (PLR) test for fluid responsiveness prediction. RECENT FINDINGS: It has been well established that either insufficient or excessive fluid administration derives in worse outcomes in critically ill patients, highlighting that a more accurate assessment of fluid management is required. Accordingly, several cardiovascular indices have been tested to improve our ability to predict patients' response to fluid loading at the bedside, the so-called functional hemodynamic monitoring...
March 20, 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28321405/prognostic-significance-of-neutrophil-to-lymphocyte-ratio-lymphocyte-to-monocyte-ratio-and-platelet-to-lymphocyte-ratio-in-patients-with-nasopharyngeal-carcinoma
#7
Aiying Lu, Haifeng Li, Yuming Zheng, Minzhong Tang, Jun Li, Huihui Wu, Weiming Zhong, Jianquan Gao, Ningjiang Ou, Yonglin Cai
The peripheral blood neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) have been reported to correlate with the prognosis of many malignancies. This study evaluated the prognostic value of pretreatment NLR, LMR, and PLR in nasopharyngeal carcinoma (NPC). A retrospective analysis of clinical and pathological data of 140 NPC patients without distant metastasis during initial treatment was conducted to identify correlations between NLR, LMR, and PLR and clinicopathological features, overall survival, and progression-free survival...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28316215/-effect-of-preoperative-monocyte-lymphocyte-ratio-on-prognosis-of-patients-with-resectable-esophagogastric-junction-cancer
#8
W J Zhou, J Wu, X D Li, Q Wang, X F Ni, J T Jiang, M Ji, C P Wu
Objective: To investigate the associations between various blood test parameters including MLR (monocyte-lymphocyte ratio) and prognosis in post-operative esophagogastric junction cancer patients. Methods: We retrospectively studied the preoperative and postoperative data of 309 patients who underwent radical surgery for esophagogastric junction cancer. The relationship between MLR, neutrophil lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and overall survival (OS) was analyzed. Results: The cutoff values of MLR、NLR and PLR were 0...
March 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28315180/inflammation-based-indexes-and-clinicopathologic-features-are-strong-predictive-values-of-preoperative-circulating-tumor-cell-detection-in-gastric-cancer-patients
#9
L Zheng, K Zou, C Yang, F Chen, T Guo, B Xiong
PURPOSE: Circulating tumor cell (CTC) count and the host inflammatory response are two independent predictors for patients with various malignant disease. Several inflammation-based indicators have been demonstrated to have prognostic value in many malignant solid tumors, including systemic immune-inflammation index (SII), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and prognostic nutrition index (PNI). The aim of this study was to evaluate the predictive value of the inflammation-based indexes including SII, NLR PLR, and PNI for CTC detection of gastric cancer patients before surgery...
March 17, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28314318/systemic-inflammatory-response-after-preoperative-chemoradiotherapy-can-affect-oncologic-outcomes-in-locally-advanced-rectal-cancer
#10
In Hee Lee, Soyoon Hwang, Soo Jung Lee, Byung Woog Kang, Dongwon Baek, Hye Jin Kim, Su Yeon Park, Jun Seok Park, Gyu Seog Choi, Jae Chul Kim, Seung Hyun Cho, Jong Gwang Kim
AIM: Systemic inflammatory response (SIR) has been reported to be an important determinant of disease progression and survival in patients with colorectal cancer. This study investigated the prognostic relevance of changes in the platelet count on survival and the predictive value of changes in platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR) on the pathological tumor response to preoperative chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC)...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28306706/assessment-of-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-in-atopic-dermatitis-patients
#11
Ying Jiang, Wencong Ma
BACKGROUND To develop new strategies for identifying atopic dermatitis patients, a better understanding of the signs for chronic inflammatory status is needed. This study was designed to investigate whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are related to the severity of atopic dermatitis (AD) assessed by the Scoring Atopic Dermatitis (SCORAD) index. MATERIAL AND METHODS A retrospective study involving 80 AD patients and 45 healthy control subjects was performed. NLR, PLR, and the number of peripheral blood eosinophils were compared between AD patients and healthy controls, and correlations between these indexes and clinical characteristics were analyzed...
March 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28295252/meta-analysis-of-biomarkers-predicting-risk-of-malignant-progression-in-barrett-s-oesophagus
#12
REVIEW
K Altaf, J-J Xiong, D De la Iglesia, L Hickey, A Kaul
BACKGROUND: Barrett's oesophagus is a precursor to the development of oesophageal adenocarcinoma. This study sought to clarify the role of genetic, chromosomal and proliferation biomarkers that have been the subjects of multiple studies through meta-analysis. METHODS: MEDLINE, Embase, PubMed and the Cochrane Library were searched for clinical studies assessing the value of p53, p16, Ki-67 and DNA content abnormalities in Barrett's oesophagus. The main outcome measure was the risk of development of high-grade dysplasia (HGD) or oesophageal adenocarcinoma...
April 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28293732/in-vitro-polyploidy-induction-changes-in-morphology-podophyllotoxin-biosynthesis-and-expression-of-the-related-genes-in-linum-album-linaceae
#13
Neda Javadian, Ghasem Karimzadeh, Mohsen Sharifi, Ahmad Moieni, Mehrdad Behmanesh
Induction of tetraploidy was performed and podophyllotoxin production increased by upregulating the expression level and enzyme activity of genes related to its biosynthesis in tetraploid compared to diploid Linum album. Linum album is a valuable medicinal plant that produces antiviral and anticancer compounds including podophyllotoxin (PTOX). To achieve homogeneous materials, in vitro diploid clones were established, and their nodal segments were exposed to different concentrations and durations of colchicine...
March 14, 2017: Planta
https://www.readbyqxmd.com/read/28293309/neutrophil-to-lymphocyte-ratio-platelet-to-lymphocyte-ratio-mean-platelet-volume-and-red-cell-distribution-width-measures-in-bells-palsy
#14
Caner Sahin, Ceyhun Varım
AIM: The purpose of this study was to investigate the usefulness of the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) Mean Platelet Volume (MPV) and Red Cell Distribution Width (RDW) in the differential diagnosis and follow-up of patients with Bells Palsy. MATERIAL AND METHODS: Twenty-eight patients diagnosed with Bells Palsy and 28 control patients were included in the study. Serum samples were analysed retrospectively on the initial presentation and the seventh day of admission...
March 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28279444/neutrophil-to-lymphocyte-ratio-platelet-to-lymphocyte-ratio-mean-platelet-volume-red-cell-distribution-width-and-plateletcrit-in-preeclampsia
#15
Burak Yücel, Batuhan Ustun
INTRODUCTION AND AIM: Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV), red cell distribution width (RDW) and plateletcrit (PCT) have all been recognized as systemic inflammatory response (SIR) markers. Our aim was to evaluate changes in NLR, PLR, RDW, MPV and PCT in preeclampsia and their use in predicting the severity of PE. STUDY DESIGN: This retrospective cohort study included 219 patients. Of them, 27 had mild PE, 82 had severe PE, and 110 were healthy, normotensive pregnant patients...
January 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/28271634/choroideremia-melanopsin-mediated-postillumination-pupil-relaxation-is-abnormally-slow
#16
Shakoor Ba-Ali, Søren Kirchhoff Christensen, Birgit Sander, Thomas Rosenberg, Michael Larsen, Henrik Lund-Andersen
PURPOSE: To investigate the rod-cone and melanopsin pupillary light response (PLR) pathways in choroideremia. METHODS: Eight patients with choroideremia and 18 healthy age-matched controls underwent chromatic pupillometry by applying blue (463 nm) and red light (643 nm) at 100 lux intensity to the right eye while recording pupil diameters. Absolute baseline pupil size (mm), normalized maximal pupil constriction and the early and late postillumination pupillary dilation, from 0 to 10 seconds and 10 to 30 seconds after the end of illumination, respectively, were determined...
March 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28264665/systemic-inflammation-based-scores-and-mortality-for-all-causes-in-hiv-infected-patients-a-master-cohort-study
#17
Elena Raffetti, Francesco Donato, Salvatore Casari, Filippo Castelnuovo, Laura Sighinolfi, Alessandra Bandera, Franco Maggiolo, Nicoletta Ladisa, Massimo di Pietro, Chiara Fornabaio, Simona Digiambenedetto, Eugenia Quiros-Roldan
BACKGROUND: Two biomarkers, the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), have been shown to be indicative of systemic inflammation and predictive of mortality in general population. We aimed to assess the association of NLR and PLR, with risk of death in HIV-infected subjects when also taking account of HIV-related factors. METHODS: We conducted a multicenter Italian cohort study from 2000 to 2012 including HIV-infected subjects naïve at antiretroviral treatment...
March 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28262507/influence-of-refractive-error-on-pupillary-dynamics-in-the-normal-and-mild-traumatic-brain-injury-mtbi-populations
#18
James Q Truong, Nabin R Joshi, Kenneth J Ciuffreda
PURPOSE: There have been several studies investigating static, baseline pupil diameter in visually-normal individuals across refractive error. However, none have assessed the dynamic pupillary light reflex (PLR). In the present study, both static and dynamic pupillary parameters of the PLR were assessed in both the visually-normal (VN) and the mild traumatic brain injury (mTBI) populations and compared as a function of refractive error. METHODS: The VN population comprised 40 adults (22-56 years of age), while the mTBI population comprised 32 adults (21-60 years of age) over a range of refractive errors (-9...
March 2, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/28260123/the-diagnostic-efficacy-of-platelet-to-lymphocyte-ratio-and-neutrophil-to-lymphocyte-ratio-in-ovarian-cancer
#19
REVIEW
Anastasia Prodromidou, Panagiotis Andreakos, Charalampos Kazakos, Dimitrios Eftimios Vlachos, Despina Perrea, Vasilios Pergialiotis
BACKGROUND: Platelet-to-lymphocyte (PLR) and Neutrophil-to-Lymphocyte (NLR) ratios have been extensively investigated in cancer. However, to date, actual guidelines concerning ovarian cancer are missing. The purpose of the present systematic review is to summarize the available evidence. METHODS: We systematically searched Medline (1966-2016), Scopus (2004-2016), ClinicalTrials.gov (2008-2016), and Cochrane Central Register of Controlled Trials CENTRAL (1999-2016) databases together with reference lists from included studies...
March 4, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28254076/computational-simulation-of-passive-leg-raising-effects-on-hemodynamics-during-cardiopulmonary-resuscitation
#20
Dong Ah Shin, Jiheum Park, Jung Chan Lee, Sang Do Shin, Hee Chan Kim
BACKGROUND AND OBJECTIVE: The passive leg-raising (PLR) maneuver has been used for patients with circulatory failure to improve hemodynamic responsiveness by increasing cardiac output, which should also be beneficial and may exert synergetic effects during cardiopulmonary resuscitation (CPR). However, the impact of the PLR maneuver on CPR remains unclear due to difficulties in monitoring cardiac output in real-time during CPR and a lack of clinical evidence. METHODS: We developed a computational model that couples hemodynamic behavior during standard CPR and the PLR maneuver, and simulated the model by applying different angles of leg raising from 0° to 90° and compression rates from 80/min to 160/min...
March 2017: Computer Methods and Programs in Biomedicine
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