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Four dimensional ct

Ivan Wen Wen Lau, Dongting Liu, Lei Xu, Zhanming Fan, Zhonghua Sun
OBJECTIVE: Current diagnostic assessment tools remain suboptimal in demonstrating complex morphology of congenital heart disease (CHD). This limitation has posed several challenges in preoperative planning, communication in medical practice, and medical education. This study aims to investigate the dimensional accuracy and the clinical value of 3D printed model of CHD in the above three areas. METHODS: Using cardiac computed tomography angiography (CCTA) data, a patient-specific 3D model of a 20-month-old boy with double outlet right ventricle was printed in Tango Plus material...
2018: PloS One
Houda Bahig, Jacques de Guise, Toni Vu, Danis Blais, Carl Chartrand-Lefebvre, Nhu Tram Nguyen, Sophie Lavertu, Jean-Pierre Guay, Stephane Bedwani, David Roberge
PURPOSE: To assess radiation dose variation to the left anterior descending artery (LAD), left main coronary artery (LMCA), left ventricle (LV), and whole heart (WH) during the cardiac cycle using dual source computed tomography (DSCT). METHODS AND MATERIALS: The present prospective study included patients with left-side breast cancer planned to undergo tangential radiation therapy. An electrocardiogram-synchronized contrast-injected DSCT scan was obtained with the patient in the treatment position, in deep-inspiration breath-hold, using retrospective sequential acquisition...
January 31, 2018: International Journal of Radiation Oncology, Biology, Physics
Takashi Shirakawa, Masao Yoshitatsu, Yasushi Koyama, Akira Kurata, Toru Miyoshi, Hiroki Mizoguchi, Takafumi Masai, Koichi Toda, Yoshiki Sawa
Determining the complex geometry of mitral valve prolapse is often difficult. We constructed 3D models of six prolapsed mitral valves for surgical assessment, and evaluated how accurately the models could replicate individual valve dimensions. 3D polygon data were constructed based on an original segmentation method for computed tomography images. The model's replication performance was confirmed via dimensional comparison between the actual hearts during surgery and those models. The results revealed that the prolapsed segments matched in all cases; however, torn chordae were replicated in four cases...
March 19, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
Basmah Safdar, Gail D'Onofrio, James Dziura, Raymond R Russell, Caitlin Johnson, Albert J Sinusas
AIMS: Coronary microvascular dysfunction (CMD) is common in patients with non-obstructive coronary arteries but has not been described in low-risk symptomatic patients. We therefore assessed the prevalence and characteristics of CMD in low to moderate risk patients with chest pain in an emergency department. METHODS AND RESULTS: We used three-dimensional Rb82 cardiac positron emission tomography/computed tomography to diagnose coronary artery disease (known or new regional defect, any coronary calcification) and CMD (low coronary flow reserve without coronary artery disease) in chest pain patients after being ruled out for acute myocardial infarction...
March 1, 2018: European Heart Journal. Acute Cardiovascular Care
Robyn Melanie Benz, Meritxell Alzamora Garcia, Felix Amsler, Johannes Voigt, Andreas Fieselmann, Anna Lucja Falkowski, Bram Stieltjes, Anna Hirschmann
Phantom-based initial performance assessment of a prototype three-dimensional (3-D) x-ray system and comparison of 3-D tomography with computed tomography (CT) were proposed. A 3-D image quality phantom was scanned with a prototype version of 3-D cone-beam CT imaging implemented on a twin robotic x-ray system using three trajectories (163 deg = table, 188 deg = upright, and 200 deg = side), six tube voltages (60, 70, 81, 90, 100, and 121 kV), and four detector doses (0.348, 0.696, 1.740, and [Formula: see text])...
January 2018: Journal of Medical Imaging
Satoshi Shibata, Shigeyuki Takamatsu, Kazutaka Yamamoto, Miu Mizuhata, Sayuri Bou, Yoshitaka Sato, Mariko Kawamura, Satoko Asahi, Yuji Tameshige, Yoshikazu Maeda, Makoto Sasaki, Tomoyasu Kumano, Satoshi Kobayashi, Hiroyasu Tamamura, Toshifumi Gabata
We evaluated the effectiveness and toxicity of proton beam therapy (PBT) for hepatocellular carcinomas (HCC) >5 cm without fiducial markers using four-dimensional CT (4D-CT) planning. The subjects were 29 patients treated at our hospital between March 2011 and March 2015. The median total dose was 76 Cobalt Gray Equivalents (CGE) in 20 fractions (range; 66-80.5 CGE in 10-32 fractions). Therapy was delivered with end-expiratory phase gating. An internal target volume (ITV) margin was added through the analysis of respiratory movement with 4D-CT...
March 14, 2018: Cancers
Nima Rostampour, Keyvan Jabbari, Mahdad Esmaeili, Mohammad Mohammadi, Shahabedin Nabavi
Background: Accurate delivery of the prescribed dose to moving lung tumors is a key challenge in radiation therapy. Tumor tracking involves real-time specifying the target and correcting the geometry to compensate for the respiratory motion, that's why tracking the tumor requires caution. This study aims to develop a markerless lung tumor tracking method with a high accuracy. Methods: In this study, four-dimensional computed tomography (4D-CT) images of 10 patients were used, and all the slices which contained the tumor were contoured for all patients...
January 2018: Journal of Medical Signals and Sensors
N Chicherova, S E Hieber, A Khimchenko, C Bikis, B Müller, P Cattin
Localizing a histological section in the three-dimensional dataset of a different imaging modality is a challenging 2D-3D registration problem. In the literature, several approaches have been proposed to solve this problem; however, they cannot be considered as fully automatic. Recently, we developed an automatic algorithm that could successfully find the position of a histological section in a micro computed tomography (μCT) volume. For the majority of the datasets, the result of localization corresponded to the manual results...
March 13, 2018: Journal of Microscopy
Hisanaga Horie, Koji Koinuma, Homare Ito, Ai Sadatomo, Daishi Naoi, Yoshihiko Kono, Yoshiyuki Inoue, Mitsuaki Morimoto, Makiko Tahara, Alan K Lefor, Naohiro Sata, Takahiro Sasaki, Hideharu Sugimoto
INTRODUCTION: Laparoscopic lateral pelvic lymph node dissection (LPLD) is technically challenging because of the complicated anatomy of the pelvic wall. To overcome this difficulty, we introduced preoperative 3-D simulation. The aim of the study is to investigate the usefulness of preoperative 3-D simulation for the safe conduct of laparoscopic LPLD for rectal cancer. METHODS: After undergoing colonoscopy, patients were brought to the radiology suite where multi-detector row CT was performed...
March 12, 2018: Asian Journal of Endoscopic Surgery
Wakoto Matsuda, Takahiro Sonomura, Satoru Honma, Sachi Ohno, Tetsuya Goto, Shuichi Hirai, Masahiro Itoh, Yoshiko Honda, Hiroki Fujieda, Jun Udagawa, Shingo Takano, Fumino Fujiyama, Shuichi Ueda
The anatomical variations of the confluence of sinuses were examined, focusing on the continuity of the superior sagittal sinus (SSS) and the transverse sinuses (TSs). In the 142 specimens studied, there were 72 symmetric cases (50.7%) and 70 asymmetric cases (49.3%). The symmetric group (no dominant type) was categorized into 34 cases of bifurcation (23.9%) and 38 cases of confluence (26.8%). The asymmetric group was categorized into 54 cases of the right-dominant type (38.0%) and 16 cases of the left-dominant type (11...
March 12, 2018: Anatomical Science International
Jenny Bertholet, Jakob Toftegaard, Rune Hansen, Esben S Worm, Hanlin Wan, Parag J Parikh, Britta Weber, Morten Høyer, Per R Poulsen
The purpose of this study was to develop, validate and clinically demonstrate fully automatic tumour motion monitoring on a conventional linear accelerator by combined optical and sparse monoscopic imaging with kilovoltage x-rays (COSMIK). COSMIK combines auto-segmentation of implanted fiducial markers in cone-beam computed tomography (CBCT) projections and intra-treatment kV images with simultaneous streaming of an external motion signal. A pre-treatment CBCT is acquired with simultaneous recording of the motion of an external marker block on the abdomen...
March 8, 2018: Physics in Medicine and Biology
Mikako Tanaka, Emi Yamashita-Mikami, Kohei Akazawa, Michiko Yoshizawa, Yoshiaki Arai, Sadakazu Ejiri
BACKGROUND: Long-term changes of trabecular microstructure in human tooth extraction socket have not been investigated. PURPOSE: To examine the trabecular microstructure of human residual ridges at various intervals following tooth extraction, and to determine whether bone remodeling activity can attain points of relative stability and when such points are reached. MATERIALS AND METHODS: Forty-four bone biopsy specimens were obtained from lower molar or premolar regions of residual ridges...
March 6, 2018: Clinical Implant Dentistry and related Research
Yasushi Shibasaki, Takanori Sakaguchi, Ryo Kitajima, Satoru Furuhashi, Ryota Kiuchi, Makoto Takeda, Takanori Hiraide, Yoshifumi Morita, Naoki Unno, Hiroya Takeuchi
Pancreaticoduodenal artery (PDA) aneurysm associated with celiac axis compression by the median arcuate ligament (MAL) is a rare disorder, but may be lethal if ruptured. Therefore, prophylactic surgical treatments need to be considered when MAL compresses the celiac axis. We herein report the usefulness of an arterial flow analysis for objectively evaluating this pathophysiology under four-dimensional flow-sensitive magnetic resonance imaging (4D-flow MRI). Celiac artery stenosis was incidentally found under contrast-enhanced CT in a 50-year-old woman with symptomatic solitary pancreatic insulinoma...
March 5, 2018: Clinical Journal of Gastroenterology
Yusuke Kimura, Takeshi Mikami, Kei Miyata, Hime Suzuki, Toru Hirano, Katsuya Komatsu, Nobuhiro Mikuni
Recent advances in computed tomography angiography (CTA) enable repeated imaging follow up for post-clipping surgery. The purpose of this study was to clarify the critical volume and configuration of the aneurysmal clip in the postoperative evaluation using volume rendering (VR) imaging, and present four-dimensional (4D)-CTA for these larger metal artifacts. A total of 44 patients with cerebral aneurysm, treated using clipping surgery, were included in this study. The metal artifact volume was assessed using CTA and the association between the type of clips and its metal artifact volume was analyzed...
March 3, 2018: Neurosurgical Review
Jesús Montúfar, Marcelo Romero, Rogelio J Scougall-Vilchis
INTRODUCTION: This article presents a novel technique for automatic cephalometric landmark localization on 3-dimensional (3D) cone-beam computed tomography (CBCT) volumes by using an active shape model to search for landmarks in related projections. METHODS: Twenty-four random CBCT scans from a public data set were imported and processed into Matlab (MathWorks, Natick, Mass). Orthogonal coronal and sagittal projections (digitally reconstructed radiographs) were created, and 2 trained active shape models were used to locate cephalometric landmarks on each...
March 2018: American Journal of Orthodontics and Dentofacial Orthopedics
Hyun-Tai Chung, Jeong Hun Kim, Jin Wook Kim, Sun Ha Paek, Dong Gyu Kim, Kook Jin Chun, Tae Hoon Kim, Yong Kyun Kim
Image co-registration is used in frameless gamma knife radiosurgery (GKSRS) to assign a stereotactic coordinate system and verify patient setup before irradiation. The accuracy of co-registration with cone beam computed tomography (CBCT) images of a Gamma Knife IconTM (GK Icon) was assessed, and the effects of the region of co-registration (ROC) were studied. CBCT-to-CBCT co-registration is used for patient setup verification, and its accuracy was examined by co-registering CBCT images taken at various configurations with a reference CBCT series...
2018: PloS One
Mahvash Hasani, Shoaleh Shahidi, Shahrzad Alsadat Shamszade
Statement of the Problem: It is crucial for clinicians to be certain about the location of mandibular canal and determine any anatomical variants relevant to it. The temporal crest canal (TCC) is a rare anatomical variant of mandibular canal that lack of awareness about its presence can complicate surgical procedures. Purpose: This study investigated the anatomical characteristics and prevalence of the TCC using CBCT. Materials and Method: This descriptive cross-section study evaluated 327 CBCTs (654 sides) from all the patients with various problems...
March 2018: Journal of Dentistry
Bryan Bednarz, Joseph Grudzinski, Ian Marsh, Abby Besemer, Dana Baiu, Jamey Weichert, Mario Otto
There is a growing need to estimate the absorbed dose to small animals from preclinical investigations involving diagnostic and therapeutic radiopharmaceuticals. This paper introduces a Monte Carlo-based dosimetry platform called RAPID, which is capable of calculating murine-specific three-dimensional (3D) dose distributions. A comparison is performed between absorbed doses calculated with RAPID and absorbed doses calculated in a commonly used reference mouse phantom called MOBY. Four test mice containing different xenografts underwent serial PET/CT imaging using a novel diagnostic therapy (theranostic) agent NM404, which can be labeled with I for imaging or I for therapy...
April 2018: Health Physics
Stefan Boehme, Frédéric P R Toemboel, Erik K Hartmann, Alexander H Bentley, Oliver Weinheimer, Yang Yang, Tobias Achenbach, Michael Hagmann, Eugenijus Kaniusas, James E Baumgardner, Klaus Markstaller
BACKGROUND: Cyclic recruitment and de-recruitment of atelectasis (c-R/D) is a contributor to ventilator-induced lung injury (VILI). Bedside detection of this dynamic process could improve ventilator management. This study investigated the potential of automated lung sound analysis to detect c-R/D as compared to four-dimensional computed tomography (4DCT). METHODS: In ten piglets (25 ± 2 kg), acoustic measurements from 34 thoracic piezoelectric sensors (Meditron ASA, Norway) were performed, time synchronized to 4DCT scans, at positive end-expiratory pressures of 0, 5, 10, and 15 cmH2 O during mechanical ventilation, before and after induction of c-R/D by surfactant washout...
February 24, 2018: Critical Care: the Official Journal of the Critical Care Forum
Hansang Lee, Helen Hong, Junmo Kim, Dae Chul Jung
PURPOSE: To develop an automatic deep feature classification (DFC) method for distinguishing benign angiomyolipoma without visible fat (AMLwvf) from malignant clear cell renal cell carcinoma (ccRCC) from abdominal contrast-enhanced computer tomography (CE CT) images. METHODS: A dataset including 80 abdominal CT images of 39 AMLwvf and 41 ccRCC patients was used. We proposed a DFC method for differentiating the small renal masses (SRM) into AMLwvf and ccRCC using the combination of hand-crafted and deep features, and machine learning classifiers...
February 23, 2018: Medical Physics
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