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https://www.readbyqxmd.com/read/28919394/concomitant-chemotherapy-and-radiotherapy-with-sbrt-boost-for-unresectable-stage-iii-non-small-cell-lung-cancer-a-phase-i-study
#1
Kristin A Higgins, Rathi N Pillai, Zhengjia Chen, Sibo Tian, Chao Zhang, Pretesh Patel, Suchita Pakkala, Jay Shelton, Seth D Force, Felix G Fernandez, Conor E Steuer, Taofeek K Owonikoko, Suresh S Ramalingam, Jeffrey D Bradley, Walter J Curran
PURPOSE: Stereotactic Body Radiation Therapy (SBRT) is now the standard of care in medically inoperable stage I non-small cell lung cancer, yielding high rates of local control. It is unknown if SBRT can be safely utilized in the locally advanced NSCLC setting. This multi-institution phase I study evaluated the safety of 44 Gy conventionally fractionated thoracic radiation with concurrent chemotherapy plus a dose escalated SBRT boost to both the primary tumor and involved mediastinal lymph nodes...
September 12, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28916844/left-sided-breast-cancer-and-risks-of-secondary-lung-cancer-and-ischemic-heart-disease-effects-of-modern-radiotherapy-techniques
#2
Stefanie Corradini, Hendrik Ballhausen, Helmut Weingandt, Philipp Freislederer, Stephan Schönecker, Maximilian Niyazi, Cristoforo Simonetto, Markus Eidemüller, Ute Ganswindt, Claus Belka
PURPOSE: Modern breast cancer radiotherapy techniques, such as respiratory-gated radiotherapy in deep-inspiration breath-hold (DIBH) or volumetric-modulated arc radiotherapy (VMAT) have been shown to reduce the high dose exposure of the heart in left-sided breast cancer. The aim of the present study was to comparatively estimate the excess relative and absolute risks of radiation-induced secondary lung cancer and ischemic heart disease for different modern radiotherapy techniques. METHODS: Four different treatment plans were generated for ten computed tomography data sets of patients with left-sided breast cancer, using either three-dimensional conformal radiotherapy (3D-CRT) or VMAT, in free-breathing (FB) or DIBH...
September 15, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28914956/ischemic-femoral-head-osteonecrosis-in-a-piglet-model-causes-three-dimensional-decrease-in-acetabular-coverage
#3
Vidyadhar V Upasani, Megan E Jeffords, Christine L Farnsworth, David Padilla, Nick Lopreiato, Olumide O Aruwajoye, Harry K W Kim
Legg-Calve-Perthes disease (LCPD) is a childhood form of ischemic osteonecrosis marked by development of severe femoral head deformity and premature osteoarthritis. The pathogenesis of femoral head deformity has been studied extensively using a piglet model of ischemic osteonecrosis, however accompanying acetabular changes have not been investigated. The purpose of this study was to determine if acetabular changes accompany femoral head deformity in a well-established piglet model of LCPD and to define the acetabular changes using 3 dimensional computed tomography (3-D CT) and modeling...
September 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28901316/comparison-of-different-width-detector-on-the-gross-tumor-volume-delineation-of-the-solitary-pulmonary-lesion
#4
Dongping Shang, Jinbo Yue, Jianbin Li, Jinghao Duan, Yong Yin, Jinming Yu
PURPOSE: To explore the impact of different width detector on the volume and geometric position of gross tumor volume (GTV) of the solitary pulmonary lesion (SPL), as well as the impact on scanning time and radiation dose during the simulation. MATERIALS AND METHODS: Twenty-three patients with SPL underwent three-dimensional computed tomography (3DCT) simulation using different width detector, followed by four-dimensional computed tomography (4DCT) scans. GTV16 and GTV4 derived from different width detectors were compared with internal gross tumor volume (IGTV) generated from 4DCT on the volume and geometric position...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28894833/ethmoidectomy-combined-with-superior-meatus-enlargement-increases-olfactory-airflow
#5
Hironobu Nishijima, Kenji Kondo, Tsutomu Nomura, Tatsuya Yamasoba
OBJECTIVES: The relationship between a particular surgical technique in endoscopic sinus surgery (ESS) and airflow changes in the post-operative olfactory region has not been assessed. The present study aimed to compare olfactory airflow after ESS between conventional ethmoidectomy and ethmoidectomy with superior meatus enlargement, using virtual ESS and computational fluid dynamics (CFD) analysis. STUDY DESIGN: Prospective computational study. MATERIALS AND METHODS: Nasal computed tomography images of four adult subjects were used to generate models of the nasal airway...
August 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28891021/anteromedial-cortical-support-reduction-in-unstable-pertrochanteric-fractures-a-comparison-of-intra-operative-fluoroscopy-and-post-operative-three-dimensional-computerised-tomography-reconstruction
#6
Shi-Min Chang, Ying-Qi Zhang, Shou-Chao Du, Zhuo Ma, Sun-Jun Hu, Xi-Zhou Yao, Wen-Feng Xiong
PURPOSE: Anteromedial cortical support reduction is favourable for secondary stability after limited sliding in unstable pertrochanteric fractures. The aim of this study was to compare the accuracy and agreement between intra-operative fluoroscopy and post-operative 3D reconstruction. MATERIALS AND METHODS: A retrospective analysis of 28 patients (mean 81.6 years) treated with short cephalomedullary nails was performed. All patients had full sets of intra-operative fluoroscopy and post-operative 3D CT images...
September 10, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28887492/freeform-fabrication-of-tissue-simulating-phantom-for-potential-use-of-surgical-planning-in-conjoined-twins-separation-surgery
#7
Shuwei Shen, Haili Wang, Yue Xue, Li Yuan, Ximing Zhou, Zuhua Zhao, Erbao Dong, Bin Liu, Wendong Liu, Barrett Cromeens, Brent Adler, Gail Besner, Ronald X Xu
Preoperative assessment of tissue anatomy and accurate surgical planning is crucial in conjoined twin separation surgery. We developed a new method that combines three-dimensional (3D) printing, assembling, and casting to produce anatomic models of high fidelity for surgical planning. The related anatomic features of the conjoined twins were captured by computed tomography (CT), classified as five organ groups, and reconstructed as five computer models. Among these organ groups, the skeleton was produced by fused deposition modeling (FDM) using acrylonitrile-butadiene-styrene...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870953/role-of-densitometric-criteria-in-evaluation-of-effectiveness-of-antiangiogenic-therapies-in-metastatic-colorectal-cancer-an-italian-clinical-experience
#8
Giuseppe Cicero, Giuseppe Lo Re, Rossella DE Luca, Federica Vernuccio, Dario Picone, Massimo Midiri, Roberto Lagalla
BACKGROUND/AIM: To evaluate the role of densitometric criterion using the Choi Criteria in the assessment of the response to antiangiogenic treatments of metastatic colorectal cancer (mCRC) compared to the RECIST criteria. PATIENTS AND METHODS: Fifty-four patients (mean age=50.6 years) affected by advanced colorectal cancer and with hepatic and possibly peritoneal and pulmonary metastases, that can be treated with bevacizumab, were prospectively evaluated by computerized tomography (CT) scan...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28870923/magnetic-resonance-compatibility-of-a-transponder-aimed-for-radiotherapy-positioning-a-phantom-study
#9
Johan Wikstrom, Ulf Isacsson, Bengt Johansson, B O Lennernäs
BACKGROUND/AIM: Electromagnetic Positioning Systems (EMP) is a new position-ing technique in four-dimensional radiotherapy. Patients with implanted transponders may be referred for magnetic resonance imaging (MRI) making it important to establish the MR safety. MATERIALS AND METHODS: Oranges were prepared with transponders and imaged on a 3T MR scanner with different sequences. Computed tomography (CT) was performed as comparison. MR artifacts were assessed. An estimation of the maximum transponder de-flection force and heating was made...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28870227/cone-beam-ct-reconstruction-for-non-periodic-organ-motion-using-time-ordered-chain-graph-model
#10
Masahiro Nakano, Akihiro Haga, Jun'ichi Kotoku, Taiki Magome, Yoshitaka Masutani, Shouhei Hanaoka, Satoshi Kida, Keiichi Nakagawa
PURPOSE: The purpose of this study is to introduce the new concept of a four-dimensional (4D) cone-beam computed tomography (CBCT) reconstruction approach for non-periodic organ motion in cooperation with the time-ordered chain graph model (TCGM) and to compare it with previously developed methods such as total variation-based compressed sensing (TVCS) and prior-image constrained compressed sensing (PICCS). MATERIALS AND METHODS: Our proposed reconstruction is based on a model including the constraint originating from the images of neighboring time phases...
September 4, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28870147/electronic-cleansing-in-computed-tomography-colonography-using-at-layer-identification-with-integration-of-gradient-directional-second-derivative-and-material-fraction-model
#11
Krisorn Chunhapongpipat, Ratinan Boonklurb, Bundit Chaopathomkul, Sirod Sirisup, Rajalida Lipikorn
BACKGROUND: In computed tomography colonography images, electronic cleansing (EC) is applied to remove opacified residual materials, called fecal-tagging materials (FTM), using positive-contrast tagging agents and laxative to facilitate polyp detection. METHODS: The proposed EC, EC prop , integrates the gradient directional second derivative into material fraction model to preserve submerged soft tissue (ST) under FTM. Three-material fraction model is used to remove FTM and artifacts at air-tagging (AT) layers and T-junctions where air, ST, and FTM material meet simultaneously...
September 4, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28870049/-clinical-effect-of-terminal-branches-portal-vein-embolization-combined-with-transcatheter-arterial-chemoembolization-on-liver-neoplasms
#12
S Y Peng, C Y Huang, X A Wang, Y F Wang, Y Y Zhang, J T Li, B Xu, X Liang, J W Wang, D F Hong, X J Cai
Objective: To analyze the efficacy of branches portal vein embolization (TBPVE) combined with transcatheter arterial chemoembolization (TACE) on liver neoplasms. Methods: From August 2016 to May 2017, there were 13 patients including 11 males and 2 females with primary hepatocellular carcinoma who underwent TBPVE+ TACE , among whom there were 11 cases with a history of HBV infection.Average age of the 13 patients was (60.8±6.2)years. The live function of all patients were Child-Pugh A classification.The CT or MRI images of each patient was reconstructed and the standard liver volume(SLV) before TBPVE+ TACE was (1 181...
September 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28862220/the-impact-of-patient-positioning-and-use-of-belly-board-on-small-bowel-toxicity-in-patients-receiving-pelvic-radiotherapy-for-gynecological-malignancies
#13
Milan Anjanappa, Rajeev Kavalakara Raghavan, Francis V James, Aswin Kumar, Susan Mathews, Sarin Bhaskaran, Shaiju Vasudevannair Sreedevi, Puthuveetil Govindan Jayaprakash
AIM: To determine the efficacy of belly board device in patients receiving postoperative radiation for gynecological malignancies in terms of setup error and acute small bowel toxicity. MATERIALS AND METHODS: Patients requiring postoperative radiation for gynecological malignancies were prospectively randomized to either treatment with supine position (supine arm) or prone position using belly board (prone arm). Each patient underwent computed tomography simulation in the assigned treatment position, and a three-dimensional conformal radiation was planned...
July 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28860628/radiomics-strategies-for-risk-assessment-of-tumour-failure-in-head-and-neck-cancer
#14
Martin Vallières, Emily Kay-Rivest, Léo Jean Perrin, Xavier Liem, Christophe Furstoss, Hugo J W L Aerts, Nader Khaouam, Phuc Felix Nguyen-Tan, Chang-Shu Wang, Khalil Sultanem, Jan Seuntjens, Issam El Naqa
Quantitative extraction of high-dimensional mineable data from medical images is a process known as radiomics. Radiomics is foreseen as an essential prognostic tool for cancer risk assessment and the quantification of intratumoural heterogeneity. In this work, 1615 radiomic features (quantifying tumour image intensity, shape, texture) extracted from pre-treatment FDG-PET and CT images of 300 patients from four different cohorts were analyzed for the risk assessment of locoregional recurrences (LR) and distant metastases (DM) in head-and-neck cancer...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28856408/three-dimensional-ct-angiography-of-anatomic-variations-in-the-pulmonary-arterial-tree
#15
Alex Fourdrain, Florence De Dominicis, Chloé Blanchard, Jules Iquille, Sophie Lafitte, Pierre-Louis Beuvry, David Michel, Geoni Merlusca, Eric Havet, Pascal Berna
PURPOSE: Anatomic variations of the pulmonary arterial tree can cause technical difficulties during pulmonary lobectomy in general and video-assisted thoracic surgery (VATS). Using CT angiography and 3D reconstruction, we sought to identify anatomic variations of the pulmonary arterial tree and assess their respective frequencies. METHODS: We retrospectively studied 88 pulmonary arterial trees in 44 patients having undergone VATS lobectomy for lung cancer over an 18-month period in Amiens University Hospital's Department of Thoracic Surgery...
August 30, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28845693/automatic-localization-of-three-dimensional-cephalometric-landmarks-on-cone-beam-ct-images-by-extracting-symmetry-features-of-the-skull
#16
Bala Chakravarthy Neelapu, Om Prakash Kharbanda, Viren Sardana, Abhishek Gupta, Srikanth Vasamsetti, Rajiv Balachandran, Harish Kumar Sardana
OBJECTIVES: To propose an algorithm for automatic localization of 3D cephalometric landmarks on CBCT data, those are useful for both cephalometric and upper airway volumetric analysis. METHODS: Twenty landmarks were targeted for automatic detection, of which twelve landmark sexists on the mid-sagittal plane. Automatic detection of mid-sagittal plane from the volume is a challenging task. Mid-sagittal plane is detected by extraction of statistical parameters of the symmetrical features of the skull...
August 27, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28845691/four-dimensional-ct-angiography-4d-cta-in-the-evaluation-of-juvenile-nasopharyngeal-angiofibromas-comparison-with-digital-subtraction-angiography-dsa-and-surgical-findings
#17
Zebin Xiao, Yingyan Zheng, Jian Li, Dehua Chen, Fang Liu, Dairong Cao
OBJECTIVES: To explore the value of four-dimensional CT angiography (4D-CTA) in the preoperative evaluation of JNAs using 320-row volume CT. METHODS: 4D-CTA and DSA data of 18 patients with histopathologically proven JNAs were retrospectively reviewed. The location, extent, feeding vessels and stage of JNAs were assessed by two radiologists independently and blindly. The agreements between both reviewers and between 4D-CTA and surgical findings for assessing the above indicators were analyzed respectively...
August 27, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28844845/lepidic-predominant-pulmonary-lesions-lpl-ct-based-distinction-from-more-invasive-adenocarcinomas-using-3d-volumetric-density-and-first-order-ct-texture-analysis
#18
Jeffrey B Alpert, Henry Rusinek, Jane P Ko, Bari Dane, Harvey I Pass, Bernard K Crawford, Amy Rapkiewicz, David P Naidich
RATIONALE AND OBJECTIVES: This study aimed to differentiate pathologically defined lepidic predominant lesions (LPL) from more invasive adenocarcinomas (INV) using three-dimensional (3D) volumetric density and first-order texture histogram analysis of surgically excised stage 1 lung adenocarcinomas. MATERIALS AND METHODS: This retrospective study was institutional review board approved and Health Insurance Portability and Accountability Act compliant. Sixty-four cases of pathologically proven stage 1 lung adenocarcinoma surgically resected between September 2006 and October 2015, including LPL (n = 43) and INV (n = 21), were evaluated using high-resolution computed tomography...
August 24, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28839405/comparative-alveolar-ridge-preservation-using-allogenous-tooth-graft-versus-free-dried-bone-allograft-a-randomized-controlled-prospective-clinical-pilot-study
#19
Chaitanya Pradeep Joshi, Cynthia Bernardo D'Lima, Urmila Chandrashekhar Samat, Prerna Ashok Karde, Agraja Ganpat Patil, Nitin Hemchandra Dani
BACKGROUND: For the first time in India, allografts from human extracted teeth were prepared. A randomized, prospective, clinicoradiographical, histological study was conducted to evaluate their efficacy in comparison with freeze-dried bone allograft (FDBA) in alveolar ridge preservation. MATERIALS AND METHODS: Graft preparation: with written consent, teeth were collected from three donors (full mouth extraction cases). Once donors' serums were tested negative for HIV, HBV, HCV, and Venereal disease research laboratory (VDRL), mineralized whole tooth allograft (WTA) and dentin allograft (DA) were prepared using the standard protocol of Tissue Bank at Tata Memorial Hospital, Mumbai, India...
April 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/28838891/interaction-effects-among-ifn-%C3%AE-874-il-2-330-il-10-1082-il-10-592-and-il-4-589-polymorphisms-on-the-clinical-progression-of-subjects-infected-with-hepatitis-b-virus-and-or-hepatitis-c-virus-a-retrospective-nested-case-control-study
#20
Qiu-Ju Gao, Jia-Xin Xie, Li-Min Wang, Qiang Zhou, Shi-Yong Zhang
BACKGROUND: The natural outcomes of hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infections vary considerably among individuals The infection may heal naturally, or patients may succumb to chronic liver diseases, including chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The mechanism is not fully understood. OBJECTIVES: To evaluate the interaction among four single nucleotide polymorphisms (SNPs) and their influence on different clinical outcomes...
August 23, 2017: BMJ Open
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