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https://www.readbyqxmd.com/read/29906589/overexpression-of-adeabc-efflux-pump-associated-with-tigecycline-resistance-in-clinical-acinetobacter-nosocomialis-isolates
#1
Ya-Sung Yang, Hsing-Yu Chen, Wei-Jane Hsu, Yu-Ching Chou, Cherng-Lih Perng, Hung-Sheng Shang, Yuan-Ting Hsiao, Jun-Ren Sun
OBJECTIVES: Tigecycline non-susceptible Acinetobacter nosocomialis (TNAN) have been discovered in clinical isolates. The resistance-nodulation-cell division (RND)-type efflux system plays a major role in tigecycline non-susceptible of Acinetobacter baumannii, but the mechanism in Acinetobacter nosocomialis remains unknown. Our aim was to analyze the contribution of efflux based tigecycline resistance in clinical A. nosocomialis isolates collected from multiple medical centers in Taiwan...
June 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29906042/primary-umbilical-endometriosis-villar%C3%A2-s-nodule-case-report
#2
Denise Niza Benardete-Harari, José Manuel Muñoz-de Cote Frade, Jaime Antonio Hidalgo-Carrera, Alberto Felgueres-Hermida, Diego Meraz-Ávila
Background: Umbilical endometriosis or Villar’s nodule is uncommon. Incidence goes up to 0.5-1.2% of all patients with endometriosis. As far as 2012, only 109 cases of umbilical endometriosis have been reported worldwide, there is no incidence reports in Mexico. Clinically, it’s a solitary node, solid and well defined, colored red, blue or black and it’s ocassionally accompanied by bleeding and dysmenorrhea. The treatment can be medical or surgical and it consists of painkillers, and hormonal suppression using GnRH analogues, hormonal contraceptives, danazol or progesterone...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29906012/tender-finger-nodule
#3
Marki E Klapperich, Brittany A Buhalog, Molly A Hinshaw
A male in his twenties presented with a tender finger nodule that had been present for 3 months. Histopathological examination revealed a dermis with nodules of necrotic, athypical epithelaia cells with high nuclear to cytoplasmic ratios. Glandular formation was present with lumens lined by columnar epithelium, consistent with digital papillary adenocarcinoma. Digital papilary adenocarcinoma is a rare malignant adnexal tumor arising from sweat glands and requires further work-up.
April 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29905601/huge-bursitis-and-bursal-synovial-osteochondromatosis-associated-with-scapular-osteochondroma-mimicking-a-giant-calcific-mass-of-the-chest-wall-a-case-report
#4
Kutsi Tuncer, Emine Izgi, Bahar Cankaya, Hayri Ogul, Mecit Kantarci
Osteochondroma is the most common benign bone tumor but it rarely arises from the scapula. Scapulothoracic bursitis is quite rare and osteochondroma is one of the unusual causes of this condition. Synovial chondromatosis may occur extremely uncommonly in this bursa. We reported an unusual case of scapulothoracic bursitis with synovial chondromatosis which is caused by osteochondroma. To the best of our knowledge, there is no defined chondromatosis in the scapulothoracic bursa secondary to scapular osteochondroma in the literature...
June 13, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29905579/a-case-of-alk-anaplastic-large-cell-lymphoma-with-aberrant-myeloperoxidase-expression-and-initial-cutaneous-presentation
#5
Alejandro A Gru, Patrick J Voorhess
Anaplastic large-cell lymphoma (ALCL) was first described in 1985 by Stein et al and is a clinically, morphologically, and immunophenotypically heterogeneous neoplasm characterized by ALK expression, rearrangement of the ALK gene, and most characteristically its occurrence in children. Clinically, cutaneous ALK+ ALCL can be divided into primary (cutaneous forms) and the much more common, secondary dissemination by a systemic lymphoma. Systemic ALK+ ALCL represents 10%-15% of childhood non-Hodgkin lymphoma and generally presents with advanced systemic disease...
November 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29905415/an-unusual-presentation-of-pulmonary-lymphoma-when-diffuse-ground-glass-opacities-can-mean-anything
#6
Anna Stainer, Paola Faverio, Francesca Bono, Alberto Pesci
Primary lung lymphoma (PLL) is a rare type of lymphoma confined to the lung at the time of diagnosis. Pulmonary diffuse large B cells lymphoma (P-DLBCL) is the second most common type of PLL and it usually appears radiologically as solitary or multiple nodules or areas of consolidation. We present the case of a 63-year-old Caucasian male who developed severe acute respiratory failure and diffuse ground glass opacities (GGO) on chest computerized tomography. Diffuse GGO may be the radiological expression of very different diseases, ranging from infectious processes to interstitial lung diseases (ILDs) and neoplastic diseases...
May 14, 2018: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/29905388/chronological-observation-of-surgically-treated-granuloma-faciale-implies-the-necessity-of-circumspect-management-for-perinasal-nodular-subset
#7
Yurie Shimoda-Komatsu, Misaki Kinoshita-Ise, Hiroaki Shimoyamada, Manabu Ohyama
Granuloma faciale (GF) is a rare chronic dermatosis with still unknown etiopathology, which usually presents a solitary, asymptomatic, smooth reddish-brown to violaceous plaques or nodules on the face. Various therapeutic approaches, including topical application of corticosteroid or tacrolimus and removal with laser, cryotherapy and surgery have been attempted; however, the outcome has been inconsistent. Herein, we report a case of perinasal nodular GF who repeatedly underwent surgical excisions after the failure of laser treatment...
June 15, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29905089/thyroid-cancer-treatment-choice-a-pilot-study-of-a-tool-to-facilitate-conversations-with-patients-with-papillary-microcarcinomas-considering-treatment-options
#8
Juan P Brito, Jae Hoon Moon, Rebecca Zeuren, Sung Hye Kong, Yeo Koon Kim, Nicole M Iñiguez-Ariza, June Young Choi, Kyu Eun Lee, Ji-Hoon Kim, Ian Hargraves, Victor Bernet, Victor Montori, Young Joo Park, R Michael Tuttle
BACKGROUND: The 2015 American Thyroid Association guidelines recognize active surveillance as an alternative to immediate surgery in patients with papillary microcarcinomas (PMCs). As a way to incorporate active surveillance as one of the management options for patients with PMCs, we describe the development and initial testing of a tool to support conversations between clinicians and patients with PMCs considering treatment options. METHODS: Thyroid Cancer Treatment Choice was developed using an iterative process based on the principles of interaction, design and participatory action research...
June 15, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29904738/implications-for-high-precision-dose-radiation-therapy-planning-or-limited-surgical-resection-after-percutaneous-computed-tomography-guided-lung-nodule-biopsy-using-a-tract-sealant
#9
Patricia M de Groot, Girish S Shroff, Judy Ahrar, Bradley S Sabloff, Garret M Gladish, Cesar Moran, Sanjay Gupta, Gregory W Gladish, Joe Y Chang, Jeremy J Erasmus
Purpose: Precision radiation therapy such as stereotactic body radiation therapy and limited resection are being used more frequently to treat intrathoracic malignancies. Effective local control requires precise radiation target delineation or complete resection. Lung biopsy tracts (LBT) on computed tomography (CT) scans after the use of tract sealants can mimic malignant tract seeding (MTS) and it is unclear whether these LBTs should be included in the calculated tumor volume or resected...
April 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29904593/case-report-pulmonary-and-liver-sarcoidosis-suspected-of-metastasis
#10
Behnam Jafari, Gholamabas Sabz, Elahe Masnavi, Roghaye Panahi, Saeid Jokar, Amrollah Roozbehi, Sajad Hasanzadeh
Introduction : Sarcoidosis is a granulomatous disease with unknown cause that can vary from an asymptomatic condition. Almost half of the patients with sarcoidosis have no symptoms. In this article, we describe a sarcoidosis patient with lung and liver engagement; it may be confused with metastasis. Case report : A 39-year-old man, known as hypothyroidism who had come to the emergency ward with dyspnea and coughing after exposure to detergents in a closed environment A 39-year-old man, known as hypothyroidism who had come to the emergency ward with dyspnea and coughing after exposure to detergents in a closed environment...
2018: F1000Research
https://www.readbyqxmd.com/read/29904242/noninvasive-imaging-of-hepatocellular-carcinoma-from-diagnosis-to-prognosis
#11
REVIEW
Han-Yu Jiang, Jie Chen, Chun-Chao Xia, Li-Kun Cao, Ting Duan, Bin Song
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a major public health problem worldwide. Hepatocarcinogenesis is a complex multistep process at molecular, cellular, and histologic levels with key alterations that can be revealed by noninvasive imaging modalities. Therefore, imaging techniques play pivotal roles in the detection, characterization, staging, surveillance, and prognosis evaluation of HCC. Currently, ultrasound is the first-line imaging modality for screening and surveillance purposes...
June 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29903641/detection-of-pulmonary-nodule-growth-with-chest-tomosynthesis-a-human-observer-study-using-simulated-nodules
#12
Christina Söderman, Åse Allansdotter Johnsson, Jenny Vikgren, Rauni Rossi Norrlund, David Molnar, Maral Mirzai, Angelica Svalkvist, Lars Gunnar Månsson, Magnus Båth
RATIONALE AND OBJECTIVES: Chest tomosynthesis has been suggested as a suitable alternative to CT for follow-up of pulmonary nodules. The aim of the present study was to investigate the possibility of detecting pulmonary nodule growth using chest tomosynthesis. MATERIALS AND METHODS: Simulated nodules with volumes of approximately 100 mm3 and 300 mm3 as well as additional versions with increasing volumes were created. The nodules were inserted into images from pairs of chest tomosynthesis examinations, simulating cases where the nodule had either remained stable in size or increased in size between the two imaging occasions...
June 11, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29903633/incidence-and-reasons-of-pancreatic-resection-in-patients-with-asymptomatic-serous-cystadenoma
#13
Carlo Lombardo, Sara Iacopi, Francesca Menonna, Niccolò Napoli, Emanuele Kauffmann, Juri Bernardini, Andrea Cacciato Insilla, Piero Boraschi, Francescamaria Donati, Carla Cappelli, Daniela Campani, Davide Caramella, Ugo Boggi
BACKGROUND/OBJECTIVES: Despite diagnostic refinements, pancreatic resection (PR) is eventually performed in some patients with asymptomatic serous cystadenoma (A-SCA). The aim of this study was to define incidence and reasons of PR in A-SCA. METHODS: A retrospective analysis of a prospectively maintained database was performed for all the patients referred for pancreatic cystic lesions (PCL) between January 2005 and March 2016. RESULTS: Overall, there were 1488 patients with PCL, including 1271 (85...
June 8, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29903487/improved-lung-nodule-diagnosis-accuracy-using-lung-ct-images-with-uncertain-class
#14
Zhiqiong Wang, Junchang Xin, Peishun Sun, Zhixiang Lin, Yudong Yao, Xiaosong Gao
BACKGROUND AND OBJECTIVE: Among all malignant tumors, lung cancer ranks in the top in mortality rate. Pulmonary nodule is the early manifestation of lung cancer, and plays an important role in its discovery, diagnosis and treatment. The technology of medical imaging has encountered a rapid development in recent years, thus the amount of pulmonary nodules can be discovered are on the raise, which means even tiny or minor changes in lung can be recorded by the CT images. This paper proposes a pulmonary nodule computer aided diagnosis (CAD) based on semi-supervised extreme learning machine(SS-ELM)...
August 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29903476/convolutional-neural-network-based-pso-for-lung-nodule-false-positive-reduction-on-ct-images
#15
Giovanni Lucca França da Silva, Thales Levi Azevedo Valente, Aristófanes Corrêa Silva, Anselmo Cardoso de Paiva, Marcelo Gattass
BACKGROUND AND OBJECTIVE: Detection of lung nodules is critical in CAD systems; this is because of their similar contrast with other structures and low density, which result in the generation of numerous false positives (FPs). Therefore, this study proposes a methodology to reduce the FP number using a deep learning technique in conjunction with an evolutionary technique. METHOD: The particle swarm optimization (PSO) algorithm was used to optimize the network hyperparameters in the convolutional neural network (CNN) in order to enhance the network performance and eliminate the requirement of manual search...
August 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29903435/cerebellar-networks-and-neuropathology-of-cerebellar-developmental-disorders
#16
Harvey B Sarnat
The cerebellar system is a series of axonal projections and synaptic circuits as networks, similar to those of the limbic system and those subserving the propagation and spread of seizures. Three principal cerebellar networks are identified and cerebellar disease often affects components of the networks other than just the cerebellar cortex. Contemporary developmental neuropathology of the cerebellum is best considered in the context of alterations of developmental processes: embryonic segmentation and genetic gradients along the three axes of the neural tube, individual neuronal and glial cell differentiation, migration, synaptogenesis, and myelination...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29903194/-effect-factors-of-the-prevalence-of-thyroid-nodules-in-zhejiang-province-in-2010
#17
Zhe Mo, Guangming Mao, Wenming Zhu, Xiaofeng Wang, Xiaoming Lou, Gangqiang Ding
OBJECTIVE: To assess the prevalence of thyroid nodules and explore the risk factors for thyroid nodules among the community residents in Zhejiang Province. METHODS: The residents of twenty-two communities in Zhejiang Province were selectedwith stratified cluster sampling. The cross-sectional survey includes questionnaire, examination on thyroid. The prevalence and related factors of thyroid nodules was described, and the possible risk factors for thyroid nodules was analyzed with logistic regression...
November 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29902675/nuclear-factor-y-still-complex-after-all-these-years
#18
REVIEW
Zachary A Myers, Ben F Holt
The NUCLEAR FACTOR-Y (NF-Y) families of transcription factors are important regulators of plant development and physiology. Though NF-Y regulatory roles have recently been suggested for numerous aspects of plant biology, their roles in flowering time, early seedling development, stress responses, hormone signaling, and nodulation are the best characterized. The past few years have also seen significant advances in our understanding of the mechanistic function of the NF-Y, and as such, increasingly complex and interesting questions are now more approachable...
June 11, 2018: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/29902339/dirofilaria-repens-an-etiological-factor-or-an-incidental-finding-in-cytologic-and-histopathologic-biopsies-from-dogs
#19
Katarzyna Paździor-Czapula, Iwona Otrocka-Domagała, Patrycja Myrdek, Mateusz Mikiewicz, Michał Gesek
Dirofilaria repens is an endemic, zoonotic parasite of carnivores, causing subcutaneous dirofilariasis, which is mostly asymptomatic. The aim of this study was to describe 22 cases of canine subcutaneous dirofilariasis. The cytologic and histopathologic samples were collected from dogs, which presented with various clinical signs such as cutaneous/subcutaneous nodules, hydropericardium, ascites, and lymphadenomegaly. The cytologic or histopathologic examination revealed purulent, pyogranulomatous, granulomatous or eosinophilic dermatitis/panniculitis, and the presence of D repens microfilariae or adults...
June 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29901712/which-t-descriptor-is-more-predictive-of-recurrence-after-sublobar-resection-whole-tumour-size-versus-solid-component-size
#20
Hang Su, Chenyang Dai, Yunlang She, Yijiu Ren, Lei Zhang, Huikang Xie, Dong Xie, Gening Jiang, Chang Chen
OBJECTIVES: We aimed to assess the predictive value of different T descriptors, including the whole tumour size (Dwhole) and solid component size (Dsolid), in patients with clinical Stage IA adenocarcinoma who underwent sublobar resection. METHODS: According to computed tomography images in the lung window, T descriptors, Dwhole and Dsolid, were applied. To evaluate the predictive value of these 2 different descriptors in predicting tumour recurrence and pathological malignant behaviours, Cox hazard regression and a receiver-operating characteristic curve analysis, respectively, were used...
June 12, 2018: European Journal of Cardio-thoracic Surgery
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