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https://www.readbyqxmd.com/read/29228030/logistic-regression-analysis-of-conventional-ultrasonography-strain-elastosonography-and-contrast-enhanced-ultrasound-characteristics-for-the-differentiation-of-benign-and-malignant-thyroid-nodules
#1
Tiantian Pang, Leidan Huang, Yingyuan Deng, Tianfu Wang, Siping Chen, Xuehao Gong, Weixiang Liu
The aim of the study is to screen the significant sonographic features by logistic regression analysis and fit a model to diagnose thyroid nodules. A total of 525 pathological thyroid nodules were retrospectively analyzed. All the nodules underwent conventional ultrasonography (US), strain elastosonography (SE), and contrast -enhanced ultrasound (CEUS). Those nodules' 12 suspicious sonographic features were used to assess thyroid nodules. The significant features of diagnosing thyroid nodules were picked out by logistic regression analysis...
2017: PloS One
https://www.readbyqxmd.com/read/29227539/mir-29b-promotes-human-aortic-valve-interstitial-cell-calcification-via-inhibiting-tgf-%C3%AE-3-through-activation-of-wnt3-%C3%AE-catenin-smad3-signaling
#2
Ming Fang, Cheng-Guang Wang, Changzhu Zheng, Jun Luo, Shiqiang Hou, Kangyong Liu, Xinming Li
Herein, we hypothesized that pro-osteogenic MicroRNAs (miRs) could play functional roles in the calcification of the aortic valve and aimed to explore the functional role of miR-29b in the osteoblastic differentiation of human aortic valve interstitial cells (hAVICs) and the underlying molecular mechanism. Osteoblastic differentiation of hAVICs isolated from human calcific aortic valve leaflets obtained intraoperatively was induced with an osteogenic medium. Alizarin red S staining was used to evaluate calcium deposition...
December 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29227411/intraoral-pleomorphic-adenoma-in-young-patients
#3
Violante Lina Assunção Alves, Maria Eduarda Pérez-de-Oliveira, Jurema Freire Lisboa de Castro, Camila Lins Vieira, Jair Carneiro Leão, Danyel Elias da Cruz Perez
BACKGROUND: Intraoral pleomorphic adenoma (PA) is rare in young individuals, with only single clinical reports or small patient series reported previously. AIM: The aim of this study was to describe the clinicopathological features of PA in 4 patients under 18 years of age, and to discuss the differential diagnosis of pediatric patients presenting with intraoral submucosal nodules. METHODS: Between 2000 and 2015, all patients of intraoral PA in patients aged ≤18 years diagnosed in the Oral Pathology Laboratory of the Universidade Federal de Pernambuco, Brazil, were retrieved for the study...
December 7, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29226306/symbioses-with-nitrogen-fixing-bacteria-nodulation-and-phylogenetic-data-across-legume-genera
#4
Michelle E Afkhami, D Luke Mahler, Jean H Burns, Marjorie G Weber, Martin F Wojciechowski, Janet Sprent, Sharon Y Strauss
How species interactions shape global biodiversity and influence diversification is a central - but also data-hungry - question in evolutionary ecology. Microbially-based mutualisms are widespread and could cause diversification by ameliorating stress and thus allowing organisms to colonize and adapt to otherwise unsuitable habitats. Yet the role of these interactions in generating species diversity has received limited attention, especially across large taxonomic groups. In the massive angiosperm family Leguminosae, plants often associate with root-nodulating bacteria that ameliorate nutrient stress by fixing atmospheric nitrogen...
December 11, 2017: Ecology
https://www.readbyqxmd.com/read/29225977/double-morphology-tertiary-syphilis-and-acquired-immunodeficiency-syndrome-a-rare-association
#5
R M Ngwanya, B Kakande, N P Khumalo
Background: Human immunodeficiency virus (HIV) and Treponema pallidum coinfection is relatively common and accounts for about 25% of primary and secondary syphilis. Tertiary syphilis in HIV-uninfected and HIV-infected patients is vanishingly rare. This is most likely due to early treatment of cases of primary and secondary syphilis. There is rapid progression to tertiary syphilis in HIV-infected patients. Case Presentation: A 49-year-old woman diagnosed with HIV Type 1 infection and cluster of differentiation 4 (CD4) count of 482 presented with a four-week history of multiple crusted plaques, nodules, and ulcers on her face, arms, and abdomen...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29225730/draft-genome-sequences-of-bradyrhizobium-shewense-sp-nov-err11t-and-bradyrhizobium-yuanmingense-ccbau-10071t
#6
Aregu Amsalu Aserse, Tanja Woyke, Nikos C Kyrpides, William B Whitman, Kristina Lindström
The type strain of the prospective 10.1601/nm.30737 sp. nov. ERR11T, was isolated from a nodule of the leguminous tree Erythrina brucei native to Ethiopia. The type strain 10.1601/nm.1463 10.1601/strainfinder?urlappend=%3Fid%3DCCBAU+10071 T, was isolated from the nodules of Lespedeza cuneata in Beijing, China. The genomes of ERR11T and 10.1601/strainfinder?urlappend=%3Fid%3DCCBAU+10071 T were sequenced by DOE-JGI and deposited at the DOE-JGI genome portal as well as at the European Nucleotide Archive. The genome of ERR11T is 9,163,226 bp in length and has 102 scaffolds, containing 8548 protein-coding and 86 RNA genes...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/29225207/parathyroid-carcinoma-occurred-in-two-glands-in-multiple-endocrine-neoplasia-1-a-report-on-a-rare-case
#7
Yoko Omi, Kiyomi Horiuchi, Kento Haniu, Momoko Tokura, Erin Nagai, Osamu Isozaki, Yoji Nagashima, Takahiro Okamoto
Primary hyperparathyroidism is the most common hormonal manifestation associated with multiple endocrine neoplasia 1 (MEN1). It is generally caused by parathyroid hyperplasia, and parathyroid carcinoma is rare. Here, we report a case of MEN1 with parathyroid carcinoma in two parathyroid glands causing primary hyperparathyroidism. A 40-year-old man with primary hyperparathyroidism due to MEN1 underwent a total parathyroidectomy. His corrected calcium and intact PTH (i-PTH) serum levels were 10.8 mg/dL and 203 pg/mL, respectively...
December 8, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29224277/-clinicopathologic-analysis-of-micronodular-thymoma-with-lymphoid-stroma
#8
X Y Wang, M Xu, L G Shi, Y Z Ding, Q Cheng, Y W Zhao
Objective: To investigate the clinicopathologic features of micronodular thymoma with lymphoid stroma(MNT). Methods: Five cases of MNT diagnosed from January 2007 to December 2016 in Henan Provincial People's Hospital were collected.Hematoxylin-Eosin staining and immunohistochemistry were used to evaluate the histological and immunophenotypic characteristics in 5 MNT cases. Epstein-Barr virus (EBV) status was detected by in situ hybridization for EBV-encoded small RNA (EBER). Polymerase chain reaction was used to detect the rearrangement of immunoglobulin genes...
December 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29224229/power-doppler-ultrasound-assessment-of-vascularization-in-hidradenitis-suppurativa-lesions
#9
Raffaele Dante Caposiena Caro, Francesco Maria Solivetti, Luca Bianchi
BACKGROUND: Ultrasound and Power Doppler (PD) ultrasound are useful tools to study and monitor Hidradenitis Suppurativa (HS) patients. OBJECTIVE: Describe the Power Doppler signal of HS nodules, abscesses, fistulas. METHODS: A retrospective analysis of PD in mild, moderate, severe HS patients, collecting all demographic and clinical data. The lesions were classified according to their ultrasound morphology, describing the vascular degree - high, moderate, minimal - and distribution - peripheral, internal, mixed...
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29222437/digital-pcr-for-gene-expression-impact-from-inherent-tissue-rna-degradation
#10
Melanie J Millier, Lisa K Stamp, Paul A Hessian
Subtle molecular differences indicate the heterogeneity present in a number of disease settings. Digital-PCR (dPCR) platforms achieve the necessary levels of sensitivity and accuracy over standard quantitative RT-PCR (qPCR) that promote their use for such situations, detecting low abundance transcript and subtle changes from gene expression. An underlying requisite is good quality RNA, principally dictated by appropriate tissue handling and RNA extraction. Here we consider the application of dPCR to measures of gene expression in pathological tissues with inherent necrosis, focusing on rheumatoid subcutaneous nodules...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29221457/capillaria-hepatica-calodium-hepaticum-infection-in-a-horse-a-case-report
#11
Akihiro Ochi, Tatsuro Hifumi, Takanori Ueno, Yoshinari Katayama
BACKGROUND: Capillaria hepatica is a zoonotic parasite in humans and animals and has a worldwide distribution. However, infections in mammals apart from rodents, which are natural hosts of the parasite, have rarely been reported. This report describes the first known case of C. hepatica infection in a horse in Japan. CASE PRESENTATION: A 3-year-old filly without clinical signs was presented at a slaughterhouse in Japan. Gross examination revealed white to tan nodules 0...
December 8, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29221348/lung-metastases-in-an-atypical-type-a-thymoma-variant
#12
Masaki Hashimoto, Yoshitane Tsukamoto, Shohei Matsuo, Toru Nakamichi, Nobuyuki Kondo, Seiki Hasegawa
A 35-year-old woman had undergone extensive thymothymectomy for type A thymoma several years ago. However, two small lung nodules were found 4 and 5 years after surgery. After a partial lung resection to remove these nodules, pathology revealed that they were metastases of the type A thymoma. A pathological re-evaluation confirmed that the primary tumor had in fact been an atypical type A thymoma variant, a subset added to the WHO classification in 2015. Pathology should be re-evaluated in all patients diagnosed with type A thymoma before 2015 since they may have the more aggressive atypical type A thymoma variant...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221316/recent-advances-in-the-management-of-pulmonary-tuberculoma-with-focus-on-the-use-of-tubeless-video-assisted-thoracoscopic-surgery
#13
REVIEW
Zhaohua Xia, Kun Qiao, Jianxing He
Pulmonary tuberculoma are benign solitary pulmonary nodules representing up to 25% of all resected solitary pulmonary nodules. However, the differentiation between pulmonary tuberculoma and lung cancer, as well as between active tuberculoma and inactive tuberculoma remains a clinical challenge. The present review summarizes the recent advances in the management of pulmonary tuberculoma, including radiological findings, the response to anti-tuberculosis treatment and surgical treatments. Application of the novel tubeless video-assisted thoracoscopic surgery (VATS) technique in both the diagnosis and treatment of pulmonary tuberculoma has been found to be safe and feasible and leads to less surgical trauma, which results in reduced length of hospitalization and better post-operative quality of life...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221314/thoracoscopic-left-s4a-subsegmentectomy
#14
Akira Hamada, Hiroyuki Oizumi, Hirohisa Kato, Jun Suzuki, Hikaru Watarai, Katsuyuki Suzuki, Takanori Sasage, Mitsuaki Sadahiro
A 63-year-old woman who underwent a left hepatic lobectomy for hilar cholangiocarcinoma was referred to our department for further management. Chest computed tomography showed a lung nodule that was increased in size to 8 mm in the S4a. The differential diagnosis was metastasis versus primary lung cancer. Thoracoscopic left S4a subsegmentectomy was performed. The operative time was 158 min. The blood loss was minimal. Air leakage was not observed, and a chest tube was removed on POD 1. The patient was discharged home on POD 3...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221313/video-assisted-thoracoscopic-surgery-vats-lower-lobe-bisegmentectomy-s7-8-for-a-central-pulmonary-metastasis
#15
Andreas Hiebinger, Thomas Weik, Horst Mertins, Johannes Bodner
Surgery for pulmonary metastasis is performed heterogeneously with regard to surgical approach [open vs. video-assisted thoracoscopic surgery (VATS)] and resection techniques (e.g., laser enucleation, electro-cautery resection, stapling). Complete tumor resection and preservation of lung parenchyma are of upmost importance. This is technically challenging, especially for central lesions close to vascular and bronchial segmental structures. Thus, simple thoracoscopic wedge resections are often not feasible. A VATS lower lobe bisegmentectomy (S7/8) was performed on a 62-year-old patient with a suspicious pulmonary nodule and a history of hemicolectomy for colorectal carcinoma...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221312/port-access-thoracoscopic-bisubsegmentectomy-of-right-upper-lobe-posterior-and-anterior-segments
#16
Hirohisa Kato, Hiroyuki Oizumi, Jun Suzuki, Akira Hamada, Hikaru Watarai, Kenta Nakahashi, Mitsuaki Sadahiro
A 64-year-old woman was admitted to our hospital with a 16-mm non-solid tumor with pure ground-glass nodule (GGN) contents in the posterior segment near the anterior segment of her right upper lung lobe that was suspicious of adenocarcinoma in situ (AIS). Three-dimensional computed tomography (3DCT) simulation was performed to identify the subsegmental artery and vein pre- or intra-operatively. Port-access thoracoscopic bisubsegmentectomy of the right upper lobe was performed. A frozen section revealed AIS...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221310/uniportal-video-assisted-thoracoscopic-surgery-left-upper-lobe-trisegmentectomy-using-flexible-tip-3d-video-scope
#17
Mathew Thomas
A 69-year-old male patient with a history of melanoma and prostate cancer was found to have a 2.6 cm PET-avid, slowly enlarging, left upper lobe lung nodule that was suspicious for either metastasis or primary lung cancer. Due to the deep location of the nodule, a wedge resection was not recommended. A diagnostic and therapeutic uniportal video-assisted thoracoscopic surgery (U-VATS) left upper lobe trisegmentectomy was performed uneventfully. Final pathology confirmed the presence of metastasis from prostate cancer without lymph node involvement...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221309/uniportal-video-assisted-thoracoscopic-right-upper-posterior-segmentectomy-with-systematic-mediastinal-lymphadenectomy
#18
Guofei Zhang, Zhijun Wu, Yimin Wu, Gang Shen, Ying Chai
Uniportal video-assisted thoracoscopic surgery (VATS) has now evolved into a sophisticated technique that can be used in some of the most complex thoracic procedures; however, this approach to segmentectomy is not standardized, and the surgical procedure varies between surgeons. Here, we describe the use of our uniportal VATS procedure during right upper posterior segmentectomy in a patient with a nodule in the right upper lobe. Subsequent mediastinal lymphadenectomy was performed. The patient has recovered well after surgery...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221308/how-to-manage-tumor-located-between-upper-division-and-lingular-segment-s3-s4-segmentectomy-and-s3b-s4-segmentectomy
#19
Shin-Ichi Yamashita, Yasuhiro Yoshida, Daisuke Hamatake, Takeshi Shiraishi, Katsunobu Kawahara, Akinori Iwasaki
Segmentectomy is one of the treatment of choice for small-sized non-small cell lung cancer (NSCLC). Although simple segmentectomy is feasible even if under thoracoscopy, complicated segmentectomy which contains more than two segmental plane divisions is difficult especially thoracoscopic surgery. We here present the case of totally thoracoscopic segmentectomy between upper division and lingular segment. In the first case, the 64-year-old female patient admitted for further examination and treatment of left lung ground glass nodule...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221286/automatic-lung-rads%C3%A2-classification-with-a-natural-language-processing-system
#20
Sebastian E Beyer, Brady J McKee, Shawn M Regis, Andrea B McKee, Sebastian Flacke, Gilan El Saadawi, Christoph Wald
Background: Our aim was to train a natural language processing (NLP) algorithm to capture imaging characteristics of lung nodules reported in a structured CT report and suggest the applicable Lung-RADS™ (LR) category. Methods: Our study included structured, clinical reports of consecutive CT lung screening (CTLS) exams performed from 08/2014 to 08/2015 at an ACR accredited Lung Cancer Screening Center. All patients screened were at high-risk for lung cancer according to the NCCN Guidelines®...
September 2017: Journal of Thoracic Disease
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