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https://www.readbyqxmd.com/read/28320084/lncrna-meg3-inhibited-osteogenic-differentiation-of-bone-marrow-mesenchymal-stem-cells-from-postmenopausal-osteoporosis-by-targeting-mir-133a-3p
#1
Qiujun Wang, Ying Li, Yuanxia Zhang, Lan Ma, Lin Lin, Jia Meng, Lihong Jiang, Liping Wang, Ping Zhou, Yina Zhang
BACKGROUND AND AIMS: Long non-coding RNA (lncRNA) MEG3 has proven to be an important regulator involved in the pathogenesis and development of various human diseases. However, the functional involvement of MEG3 in postmenopausal osteoporosis (PMOP) and its mechanism is still unclear. METHODS: Bone marrow mesenchymal stem cells (BMSCs) were isolated and cultured from mouse pathologic models and patients with PMOP, respectively. The expression of MEG3 and miR-133a-3p in BMSCs was detected using qRT-PCR...
March 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28319285/color-doppler-ultrasound-early-diagnoses-simulator-of-proliferative-nodule-in-congenital-melanocytic-nevus
#2
P Giavedoni, L Aranibar, X Wortsman
Congenital melanocytic nevus (CMN) is a benign proliferation of cutaneous melanocytes that arises as the result of abnormal growth, development, or migration of melanoblasts (1) . They are clinically evident at birth and usually produce a high degree of stress among physicians and parents due to the risk of malignant transformation. In spite that the actual lifetime risk of developing melanoma from a small or medium-sized CMN is unknown, and some reports estimate this risk to be less than 5%, any recent-onset palpable nodule in a CMN may be worrisome...
March 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28319284/advanced-squamous-cell-carcinoma-of-the-axillae-mimicking-hidradenitis-suppurativa
#3
Clio Dessinioti, Mikaella Plaka, Chrisa Zisimou, Eleftheria Christofidou, Christina Antoniou, Alexander J Stratigos
A 56 year-old man presented to our Hidradenitis Clinic with an exophytic, bovine-red, ulcerated plaque in the left axillae (figure 1). He reported that he was diagnosed with hidradenitis suppurativa when this lesion first appeared 8 years ago, as a single small, occasionally purulent, nodule, that had enlarged considerably over the past 7 months. He had previously received oral and topical antibiotics with no improvement. This article is protected by copyright. All rights reserved.
March 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28319177/radiological-features-of-primitive-neuroectodermal-tumors-in-intra-abdominal-and-retroperitoneal-regions-a-series-of-18-cases
#4
Xiaoping Yi, Wenguang Liu, Youming Zhang, Desheng Xiao, Hongling Yin, Xueying Long, Li Li, Hongyan Zai, Minfeng Chen, Wenzheng Li, Lunquan Sun
OBJECTIVES: To characterize the imaging and clinicopathological features of primitive neuroectodermal tumors (PNETs) arising in intra-abdominal and retroperitoneal regions. METHODS: Eighteen patients with histopathologically proven intra-abdominal and retroperitoneal PNET were enrolled; computed tomography was performed for all cases, and magnetic resonance imaging was performed for a single case. Typical computed tomography and magnetic resonance imaging findings, including morphology, texture and enhancement features, as well as clinicopathological characteristics and prognosis data were retrospectively analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28318536/chromobacterium-violaceum-infection-in-a-horse
#5
Márcia Elisa Hammerschmitt, Veronica Machado Rolim, Gustavo Geraldo Medina Snel, Franciele Maboni Siqueira, David Driemeier, Saulo Petinatti Pavarini
Chromobacterium violaceum is an opportunistic pathogen of mammals that produces characteristic violet pigment in bacterial culture. We report pneumonia and septicaemia caused by C. violaceum in a horse. Necropsy examination was performed on a 3-year-old Quarter Horse stallion with a history of recurrent episodes of pneumonia, fever, dyspnoea and sanguineous nasal discharge. The lungs were not collapsed, but they contained dark red foci mixed with white areas, and multiple nodules of firm consistency. Within the liver and kidney there were randomly distributed, multifocal, white pinpoint lesions (0...
March 16, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28316152/-long-term-follow-up-to-identify-the-rectal-potentially-malignant-nodules-in-female-by-digital-rectal-examination
#6
S S Wang, J Y Zhou, Z J Wang, S R Su, J Sun, R G W Sharen
Objective: To investigate the characteristics of the rectal potentially malignant nodules in female by digital rectal examination (DRE). Methods: Retrospectively, we collected the medical information and follow-up of rectal nodules cases diagnosed as benign by DRE during the health check-up in our hospital from Jan 2002 to Dec 2015. All nodules were recorded position, size, shape, hardness and mobility. Statistical analysis was performed to select the potentially malignant cases of postoperative pathological diagnosis and disappeared nodules followed up by DRE...
March 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28315918/fluorrine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-of-adult-liver-langerhans-cell-histiocytosis
#7
Hengshan Ji, Jiang Wu, Guifen Yang, Chuanjin Sun, Hong Zhu, Longjiang Zhang
OBJECTIVE: Adult liver Langerhans cell histiocytosis (LCH) is an extremely rare desease. This paper reports a 40 years old male patient who was diagnosed as liver LCH though ultrasound-guided liver biopsy. The initial Fluorrine-18- fluorodeoxyglucose positron emission tomography/ computed tomography ((18)F-FDG PET/CT) showed multiple nodular low-density lesions in liver without obvious elevated (18)F-FDG uptake. Four years later, the follow-up (18)F-FDG PET/CT showed the liver multiple lesions with slightly elevated (18)F-FDG uptake...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28315859/heteromorphism-of-homomorphic-sex-chromosomes-in-two-anole-species-squamata-dactyloidae-revealed-by-synaptonemal-complex-analysis
#8
Artem P Lisachov, Vladimir A Trifonov, Massimo Giovannotti, Malcolm A Ferguson-Smith, Pavel M Borodin
Iguanians (Pleurodonta) are one of the reptile lineages that, like birds and mammals, have sex chromosomes of ancient origin. In most iguanians these are microchromosomes, making a distinction between the X and Y as well as between homeologous sex chromosomes in other species difficult. Meiotic chromosome analysis may be used to elucidate their differentiation, because meiotic prophase chromosomes are longer and less condensed than metaphase chromosomes, and the homologues are paired with each other, revealing minor heteromorphisms...
March 18, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28315819/a-case-report-of-thoracic-endometriosis-a-rare-cause-of-haemothorax
#9
Lina Pankratjevaite, Diana Samiatina-Morkuniene
INTRODUCTION: The presence of endometrial tissue in airways, pleura and lung parenchyma is called thoracic endometriosis syndrome (TES). It is a rare pathology, and typically consists of catamenial pneumothorax, haemothorax, haemoptysis, and pulmonary nodules. We report a case of a 36-year-old woman with thoracic endometriosis causing catamenial haemothorax. CONCLUSIONS: The diagnosis of thoracic endometriosis is complicated and often delayed. TES should be suspected in a reproductive age woman with exacerbating symptoms during the menstruation...
March 4, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28314535/risk-stratification-for-lung-nodules-size-isn-t-everything
#10
EDITORIAL
Takashi Eguchi, Prasad S Adusumilli
No abstract text is available yet for this article.
February 16, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28314525/intraoperative-electromagnetic-navigational-bronchoscopic-localization-of-small-deep-or-subsolid-pulmonary-nodules
#11
Abbas Abbas, Sagar Kadakia, Vishnu Ambur, Kimberly Muro, Larry Kaiser
BACKGROUND: Localizing small or deep pulmonary nodules or subsolid ground-glass opacities often is difficult during video-assisted thoracoscopic surgery (VATS) or robotic-assisted thoracoscopic surgery (RATS). This can result in larger resections or conversion to thoracotomy. The goal of this study is to evaluate the role of electromagnetic navigational bronchoscopic localization (ENBL) as a safe and accurate intraoperative method to localize small, deep, or subsolid nodules. METHODS: This is a single-institution, single-surgeon retrospective study of all patients (51) who underwent combined ENBL and resection of 54 nodules between May 2013 and August 2015...
February 7, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28314132/rhizobial-symbiosis-alleviates-polychlorinated-biphenyls-induced-systematic-oxidative-stress-via-brassinosteroids-signaling-in-alfalfa
#12
Xiaomi Wang, Ying Teng, Ning Zhang, Peter Christie, Zhengao Li, Yongming Luo, Jun Wang
The role of symbiotic rhizobia in the alleviation of polychlorinated biphenyl (PCB)-induced phytotoxicity in alfalfa and the brassinosteroid (BR) hormone signaling involved were investigated during phytoremediation. The association between alfalfa and Sinorhizobium meliloti was adopted as a remediation model. Phytotoxicity due to PCB 77 (3,3',4,4'-tetrachlorobiphenyl) exerted adverse impacts on plant performance (biomass accumulation and photosynthesis) and elicited cellular oxidative stress (overproduction of reactive oxygen species, lipid peroxidation, and cell necrosis) which was largely attenuated by pre-inoculation with S...
March 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28306188/protein-modelling-to-understand-fgb-mutations-leading-to-congenital-hypofibrinogenaemia
#13
A Casini, R Vilar, Y Beauverd, D Aslan, K Devreese, V Mondelaers, L Alberio, C Gubert, P de Moerloose, M Neerman-Arbez
INTRODUCTION: Congenital hypofibrinogenaemia is a quantitative fibrinogen disorder characterized by proportionally decreased levels of functional and antigenic fibrinogen. Mutations accounting for quantitative fibrinogen disorders are relatively frequent in the conserved COOH-terminal globular domains of the γ and Bβ chains. The latter mutations are of particular interest since the Bβ-chain is considered the rate-limiting chain in the hepatic production of the fibrinogen hexamer. AIM: The aim of this study was to study the molecular pattern of four patients with congenital hypofibrinogenaemia...
March 17, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28303318/bone-alkaline-phosphatase-and-tartrate-resistant-acid-phosphatase-potential-co-regulators-of-bone-mineralization
#14
Cecilia Halling Linder, Barbro Ek-Rylander, Michael Krumpel, Maria Norgård, Sonoko Narisawa, José Luis Millán, Göran Andersson, Per Magnusson
Phosphorylated osteopontin (OPN) inhibits hydroxyapatite crystal formation and growth, and bone alkaline phosphatase (BALP) promotes extracellular mineralization via the release of inorganic phosphate from the mineralization inhibitor inorganic pyrophosphate (PPi). Tartrate-resistant acid phosphatase (TRAP), produced by osteoclasts, osteoblasts, and osteocytes, exhibits potent phosphatase activity towards OPN; however, its potential capacity as a regulator of mineralization has not previously been addressed...
March 16, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28302777/complete-genome-sequences-of-three-rhizobium-gallicum-symbionts-associated-with-common-bean-phaseolus-vulgaris
#15
Patricia Bustos, Rosa Isela Santamaría, Olga María Pérez-Carrascal, José Luis Acosta, Luis Lozano, Soledad Juárez, Irma Martínez-Flores, Esperanza Martínez-Romero, Miguel Ángel Cevallos, David Romero, Guillermo Dávila, Pablo Vinuesa, Fabiola Miranda, Ernesto Ormeño, Víctor González
The whole-genome sequences of three strains of Rhizobium gallicum reported here support the concept that the distinct nodulation host ranges displayed by the symbiovars gallicum and phaseoli can be largely explained by different symbiotic plasmids.
March 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28302381/an-entomopathogenic-bacterium-xenorhabdus-hominickii-anu101-produces-oxindole-and-suppresses-host-insect-immune-response-by-inhibiting-eicosanoid-biosynthesis
#16
Md Sadekuzzaman, Youngjin Park, Seunghee Lee, Kunwoo Kim, Jin Kyo Jung, Yonggyun Kim
An entomopathogenic bacterium, Xenorhabdus hominickii ANU101, was isolated from an entomopathogenic nematode, Steinernema monticolum. X. hominickii exhibited significant insecticidal activities at ≥ 6.6 × 10(2) colony-forming units per larva against a lepidopteran insect, Spodoptera exigua with hemocoelic injection. The insecticidal activity of X. hominickii was reduced by an addition of arachidonic acid (AA, a catalytic product of PLA2), but enhanced by an addition by dexamethasone (DEX, a specific inhibitor of PLA2)...
March 13, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28302348/cone-beam-ct-guided-chemoembolization-of-probable-hepatocellular-carcinomas-smaller-than-1-cm-in-patients-at-high-risk-of-hepatocellular-carcinoma
#17
Jin Woo Choi, Hyo-Cheol Kim, Jeong-Hoon Lee, Su Jong Yu, Eun Ju Cho, Min-Uk Kim, Saebeom Hur, Myungsu Lee, Hwan Jun Jae, Jin Wook Chung
PURPOSE: To evaluate the effectiveness and safety of cone-beam computed tomography (CT)-guided chemoembolization for probable hepatocellular carcinomas (HCCs) smaller than 1 cm in patients at high risk for HCC. MATERIALS AND METHODS: From December 2009 to May 2014, 57 patients (43 male and 14 female; mean age, 61.1 y) at high risk for HCC underwent cone-beam CT-guided conventional chemoembolization for 79 treatment-naive probable HCCs < 1 cm. Probable HCCs were diagnosed when hepatic nodules showed arterial enhancement and washout on dynamic CT or magnetic resonance images...
March 14, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28302234/tuberculous-dactylitis-with-concomitant-thyroid-involvement-a-rare-presentation-of-childhood-tuberculosis
#18
Sobia Qamar, Farrah Naz, Samia Naz, Iftikhar Ejaz
Extrapulmonary tuberculosis rarely presents as thyroid involvement along with other manifestations, and poses a diagnostic challenge on account of paucibacillary nature of disease. In general, the diagnosis of tuberculosis is based on epidemiological risk factors, clinical features, imaging studies, in addition to a positive skin testing or Interferon Gamma Release Assay (IGRA). A 14-year boy presented with history of fever and weight loss for one year. On examination, he had painful swelling of fingers and toes along with a painless thyroid nodule and squint...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28302221/-distant-metastasis-and-survival-outcomes-after-computed-tomography-guided-needle-biopsy-in-stage-i-ii-non-small-cell-lung-cancer
#19
Jingli Fan, Keke Zhai, Tingting Ren, Xiao Feng, Lin Sui, Jing Hu, Qingwei Meng
BACKGROUND: Computed tomography-guided needle biopsy (CTNB) is a well-established and commonly used technique for diagnosing pulmonary nodules with high accuracy and safety. Needle-tract implantation after CTNB has been reported in various reports. The aim of this study is to evaluate whether preoperative CTNB affected the distant metastasis and overall survival in pathological stage I-II lung cancer patients. METHODS: A total of 1,234 patients with pathological stage I-II non-small cell lung cancer were collected...
March 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28301993/outcome-of-living-donor-liver-transplant-for-hepatocellular-carcinoma-15-year-single-center-experience-in-egypt
#20
Refaat Kamel, Yaser Hatata, Karim Hosny, Ahmed Nabil, Alaa El-Deen Abd-Allah, Aaser Mostafa, Amr Abdel-Aal, Mahmoud Z Elganzoury, Osama Elmalt, Ibrahim Marwan, Adel Hosny
OBJECTIVES: Liver transplant performed for hepatocellular carcinoma must adhere to criteria for the size and number of focal hepatic lesions to lower the incidence of recurrence and achieve survival rates comparable to patients transplanted for other indications. Since the Milan criteria were established in 1996, there have been many less restrictive criteria yielding similar results. Our aim was to identify the prognostic factors for patient survival and for recurrence of hepatocellular carcinoma for patients within and beyond the Milan criteria...
March 2017: Experimental and Clinical Transplantation
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