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https://www.readbyqxmd.com/read/28449499/regional-dietary-characteristics-and-bronchial-foreign-body-a-repeated-misdiagnosis-caused-by-a-red-pepper
#1
Yutian Lai, Jian Huang, Xudong Zhou, Heng Du, Guowei Che
Bronchial foreign body is a common health problem worldwide, types of bronchial foreign bodies are variegated, depending on patient age and cultural background including religious beliefs as well as alimentary habits. However, misdiagnoses caused by regional dietary correlation factors were rarely concerned. In this case, a 52-year-old woman with aggravated cough and hemosputum took thoracic CT scan twice and flexible fiberoptic bronchoscopy 5 times, which all revealed the chronic pulmonary inflammation. Furthermore, the biopsies showed bronchial granulation nodule formation...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449495/laser-resection-of-pulmonary-nodule-via-uniportal-thoracoscopic-surgery
#2
Calvin S H Ng, Freddie Capili, Ze-Rui Zhao, Peter S Y Yu, Jacky Y K Ho, Rainbow W H Lau
Uniportal video-assisted thoracic surgery (VATS) lung wedge resection usually requires three devices, thoracoscope, lung retracting instrument and an endo-stapler cutter to perform the procedure. With advances in miniaturization of the thoracoscope and lung retracting instruments, a major limitation to operating through a smaller uniportal incision has become the endo-stapler. We describe the surgical technique for uniportal VATS laser lung resection which uses a much narrower laser catheter device to replace the endo-stapler for resection...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449489/electromagnetic-navigational-bronchoscopy-with-dye-marking-for-identification-of-small-peripheral-lung-nodules-during-minimally-invasive-surgical-resection
#3
Juan A Muñoz-Largacha, Michael I Ebright, Virginia R Litle, Hiran C Fernando
BACKGROUND: Identification of small peripheral lung nodules during minimally invasive resection can be challenging. Electromagnetic navigational bronchoscopy (ENB) with injection of dye to identify nodules can be performed by the surgeon immediately prior to resection. We evaluated the effectiveness of ENB with dye marking to aid minimally invasive resection. METHODS: Patients with peripheral pulmonary nodules underwent ENB before planned thoracoscopic or robotic-assisted thoracoscopic resection...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449476/prognostic-impact-of-m-descriptors-of-the-8th-edition-of-tnm-classification-of-lung-cancer
#4
Margarida Dias, Ana Antunes, Sérgio Campainha, Sara Conde, Ana Barroso
BACKGROUND: The 8th edition of the tumor, node and metastasis (TNM) classification of lung cancer will be enacted in January 2017. The aim of this study was to analyze the survival differences among the three new categories of metastatic disease: intrathoracic metastasis (M1a), single extrathoracic metastasis (M1b) and multiple extrathoracic metastases (M1c) in our cohort of patients with non-small cell lung cancer (NSCLC). METHODS: This is a retrospective single-center study including NSCLC patients with metastatic disease at diagnosis...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449455/the-many-facets-of-diagnostic-bronchoscopy-for-pulmonary-ground-glass-nodules
#5
EDITORIAL
Christine Chavez, Takehiro Izumo
No abstract text is available yet for this article.
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449284/pediatric-melanoma
#6
REVIEW
Christina Stefanaki, Leonidas Chardalias, Efthymia Soura, Alexandra Katsarou, Alexander Stratigos
Pediatric melanoma, although rare, is the most common skin cancer in children. Our current knowledge on pediatric melanoma incidence trends is expanding, as several studies have addressed this issue with conflicting results. Known risk factors for pediatric melanoma include family history of melanoma, a previous history of malignancy, large congenital nevi, numerous melanocytic nevi, sunburns, increased UV exposure and a sun-sensitive phenotype. In younger children melanoma more often presents with atypical features, such as a changing, amelanotic or uniformly colored, often bleeding lesion, not fulfilling in most cases the conventional ABCDE criteria...
April 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28448992/bethesda-made-it-clearer-a-review-of-542-patients-in-a-single-institution
#7
Yunus Acar, Lütfi Doğan, H Erhan Güven, Bülent Aksel, Niyazi Karaman, Cihangir Özaslan, M Ali Gülçelik
BACKGROUND: It is essential to interpret fine needle aspiration biopsy (FNAB) material correctly to create a common language among pathologists and surgeons, leading to a uniform approach to thyroid nodule management. We aimed to compare FNAB reports of patients at our institution who were treated with total thyroidectomy, before and after the Bethesda classification system. PATIENTS AND METHODS: Patients who underwent total thyroidectomy for thyroid nodules are reviewed...
March 21, 2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28448653/exclusion-of-eligible-indeterminate-thyroid-nodules-in-estimates-of-negative-predictive-value-for-the-gene-expression-classifier
#8
Quan-Yang Duh, Catherine Rahilly-Tierney, Hossein Gharib
No abstract text is available yet for this article.
April 27, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28448647/exclusion-of-eligible-indeterminate-thyroid-nodules-in-estimates-of-negative-predictive-value-for-the-gene-expression-classifier
#9
Zaid Al-Qurayshi, Andrew B Sholl, Emad Kandil
No abstract text is available yet for this article.
April 27, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28448414/computed-tomography-features-of-benign-and-malignant-calcified-thyroid-nodules-a-single-center-study
#10
Donghyun Kim, Dong Wook Kim, Young Jin Heo, Jin Wook Baek, Yoo Jin Lee, Young Mi Park, Hye Jin Baek, Soo Jin Jung
OBJECTIVE: No previous studies have investigated thyroid calcification on computed tomography (CT) quantitatively by using Hounsfield unit (HU) values. This study aimed to analyze quantitative HU values of thyroid calcification on preoperative neck CT and to assess the characteristics of benign and malignant calcified thyroid nodules (CTNs). MATERIALS AND METHODS: Two hundred twenty patients who underwent neck CT before thyroid surgery from January 2015 to June 2016 were included...
April 26, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28447904/fine-needle-aspiration-versus-frozen-section-in-the-evaluation-of-malignant-thyroid-nodules-in-patients-with-the-diagnosis-of-suspicious-for-malignancy-or-malignancy-by-fine-needle-aspiration
#11
Qin Ye, Jennifer S Woo, Qunzi Zhao, Ping Wang, Pintong Huang, Lirong Chen, Xin Li, Kanlun Xu, Ying Yong, Stephanie Sung-Eun Yang, Jianyu Rao
CONTEXT: - The Bethesda System for Reporting Thyroid Cytopathology recommends against the use of intraoperative frozen section (FS) during lobectomy of a thyroid nodule with a fine-needle aspiration (FNA) diagnosis of malignant. Bethesda recommendations for FS in the FNA category of suspicious for malignancy (SFM) is less well-defined. In some institutions in China, FS examination is performed during lobectomy even for FNA-proven malignant cases. OBJECTIVE: - -To compare the efficacy of FNA versus FS in the evaluation of malignant thyroid lesions...
May 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28447742/bone-morphogenetic-protein-9-stimulates-callus-formation-in-osteoporotic-rats-during-fracture-healing
#12
Xing Wang, Jun Huang, Fan Huang, Jian-Chun Zong, Xi Tang, Yang Liu, Qiong-Fang Zhang, Yang Wang, Liang Chen, Liang-Jun Yin, Bai-Cheng He, Zhong-Liang Deng
Fracture healing involves the coordinated actions of multiple cytokines. Bone morphogenetic protein 9 (BMP9) is an important factor in bone formation. The present study aimed to investigate the osteogenic potential of bone marrow stem cells (BMSCs) in response to adenoviral (Ad)BMP9, and the early fracture repair properties of AdBMP9 in surgically‑created fractures in osteoporotic rats. Alkaline phosphatase (ALP) activity was assayed and matrix mineralization was examined by Alizarin Red S staining. mRNA and protein expression levels of BMP9, runt‑related transcription factor 2 (RUNX2) and type 1 collagen (COL‑1) were detected in vitro and in vivo...
March 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28447734/high-glucose-promotes-the-osteogenic-differentiation-capability-of-human-periodontal-ligament-fibroblasts
#13
Sujiwan Seubbuk, Hathaitip Sritanaudomchai, Julalux Kasetsuwan, Rudee Surarit
Periodontal ligament fibroblasts (PDLFs) are important cells, which are involved in maintaining tooth integrity. Diabetes has been found to be associated with periodontal disease in a bidirectional manner. The aim of the present study was to investigate the stemness properties of human PDLFs (HPDLFs) in high glucose conditions. HPDLFs were analyzed for their osteogenic differentiation capacity by inducing the cells with osteogenic medium in various glucose concentrations. The gene expression was then examined using reverse transcription‑quantitative polymerase chain reaction analysis, and examinations of alkaline phosphatase activity and nodule formation were performed...
March 16, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28447383/manganese-transport-is-essential-for-n2-fixation-by-rhizobium-leguminosarum-in-bacteroids-from-galegoid-but-not-phaseoloid-nodules
#14
Graham Hood, Vinoy Ramachandran, Alison East, J Allan Downie, Philip S Poole
Rhizobium leguminosarum has two high-affinity Mn(2+) transport systems encoded by sitABCD and mntH. In symbiosis, sitABCD and mntH were expressed throughout nodules and also strongly induced in Mn(2+) -limited cultures of free-living cells. Growth of a sitA mntH double mutant was severely reduced under Mn(2+) limitation and sitA and mntH single mutants were more sensitive to oxidative stress. The double sitA mntH mutant of R. leguminosarum was unable to fix nitrogen (Fix(-) ) with legumes belonging to the galegoid clade (Pisum sativum, Vicia faba and Vicia hirsuta)...
April 26, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28447179/influence-of-inherent-mechanophenotype-on-competitive-cellular-adherence
#15
Manisha K Shah, Iris H Garcia-Pak, Eric M Darling
Understanding the role of mechanophenotype in competitive adherence of cells to other cells versus underlying substrates can inform such processes as tissue development, cancer progression, and wound healing. This study investigated how mechanophenotype, defined by whole-cell, elastic/viscoelastic properties for the perinuclear region, and cellular assembly are intertwined through the mechanosensing process. Atomic force microscopy was used to characterize the temporal elastic/viscoelastic properties of individual and assembled fibroblasts grown on substrates with elastic moduli above, below, or similar to whole-cell mechanophenotypes measured for three, genetically modified cell lines...
April 26, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28447057/liver-resection-for-hepatocellular-carcinoma-%C3%A2-5-cm
#16
Giuseppe Maria Ettorre, Giovanni Battista Levi Sandri, Marco Colasanti, Gianluca Mascianà, Edoardo de Werra, Roberto Santoro, Pasquale Lepiane, Marzia Montalbano, Mario Antonini, Giovanni Vennarecci
BACKGROUND: Management of hepatocellular carcinoma (HCC) larger than 5 cm is still debated. The aim of our study was to compare morbidity and mortality after the surgical resection of HCC according to the nodule size. METHODS: Since 2001, 429 liver resections for HCC were performed in our institution. We divided the cohort into two groups, 88 patients in group 1 patients with HCC diameter from 5 to 10 cm and 39 patients in group 2 with HCC diameter ≥10 cm. RESULTS: In 30...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28446971/navigation-bronchoscopy-for-diagnosis-and-small-nodule-location
#17
REVIEW
Juan A Muñoz-Largacha, Virginia R Litle, Hiran C Fernando
Lung cancer continues to be the most common cause of cancer death. Screening programs for high risk patients with the use of low-dose computed tomography (CT) has led to the identification of small lung lesions that were difficult to identify using previous imaging modalities. Electromagnetic navigational bronchoscopy (ENB) is a novel technique that has shown to be of great utility during the evaluation of small, peripheral lesions, that would otherwise be challenging to evaluate with conventional bronchoscopy...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28446940/a-case-of-disseminated-peritoneal-leiomyomatosis-after-two-laparoscopic-procedures-due-to-uterine-fibroids
#18
Michał Ciebiera, Aneta Słabuszewska-Jóźwiak, Kornelia Zaręba, Grzegorz Jakiel
Disseminated peritoneal leiomyomatosis (DPL) is a rare disorder characterized by the presence of multifocal nodules and tumors composed of proliferating smooth muscle tissue, spread throughout the peritoneum. Estrogens and progesterone are considered to be the main factors initiating the formation of disseminated leiomyomatosis. Disseminated peritoneal leiomyomatosis is often asymptomatic, and acyclic vaginal bleeding or pain in the lower abdomen is associated with leiomyomatous rebuilt uterus corpus. Disseminated peritoneal leiomyomatosis can have other ambiguous presentation...
2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/28446918/microrna-and-transcription-factor-key-players-in-plant-regulatory-network
#19
REVIEW
Abdul F A Samad, Muhammad Sajad, Nazaruddin Nazaruddin, Izzat A Fauzi, Abdul M A Murad, Zamri Zainal, Ismanizan Ismail
Recent achievements in plant microRNA (miRNA), a large class of small and non-coding RNAs, are very exciting. A wide array of techniques involving forward genetic, molecular cloning, bioinformatic analysis, and the latest technology, deep sequencing have greatly advanced miRNA discovery. A tiny miRNA sequence has the ability to target single/multiple mRNA targets. Most of the miRNA targets are transcription factors (TFs) which have paramount importance in regulating the plant growth and development. Various families of TFs, which have regulated a range of regulatory networks, may assist plants to grow under normal and stress environmental conditions...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28445128/3-dimensional-micropillar-drug-screening-identifies-fgfr2-iiic-overexpression-as-a-potential-target-in-metastatic-giant-cell-tumor
#20
Seung Tae Kim, Jusun Kim, Sumin Shin, Sun Young Kim, Dongwoo Lee, Bosung Ku, Yong Sung Shin, Jhingook Kim, Jeeyun Lee
We established two patient derived tumor cells (PDCs) from right and left pulmonary metastatic lesions respectively of a patient with giant cell tumor. At that time, patient-derived tumor cells from right and left surgical specimens were collected and cultured. High-throughput screening (HTS) for 24 drugs was conducted with a micropillar/microwell chip platform using giant cell tumor PDCs. Using 6 doses per drug in 6 replicates for giant cell tumor PDCs, the dose response curves and corresponding IC50 values were calculated from the scanned images using the S+ Chip Analyzer...
April 6, 2017: Oncotarget
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