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https://www.readbyqxmd.com/read/28925992/efficacy-of-combining-ing4-and-trail-genes-in-cancer-targeting-gene-virotherapy-strategy-first-evidence-in-preclinical-hepatocellular-carcinoma
#1
A G El-Shemi, A M Ashshi, E Oh, B-K Jung, M Basalamah, A Alsaegh, C-O Yun
Current treatments of hepatocellular carcinoma (HCC) are ineffective and unsatisfactory in many aspects. Cancer-targeting gene virotherapy using oncolytic adenoviruses (OAds) armed with anticancer genes has shown efficacy and safety in clinical trials. Nowadays, both inhibitor of growth 4 (ING4); as a multimodal tumor suppressor gene, and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL); as potent-apoptosis inducing gene, are experiencing a renaissance in cancer gene therapy. Herein we investigated the antitumor activity and safety of mono-and combined therapy with OAds armed with ING4 (Ad-ΔB/ING4) and TRAIL (Ad-ΔB/TRAIL) gene, respectively, on preclinical models of human HCC...
September 19, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28925738/psychometric-properties-of-the-saint-louis-university-mental-status-examination
#2
Susan K Shwartz, Robin D Morris, Suzanne Penna
The Saint Louis University Mental Status (SLUMS) Examination is a brief screening measure for mild neurocognitive disorder developed for use with veterans. To date, there has been a paucity of research on its psychometric properties. The purpose of this study is to evaluate the psychometric properties of the SLUMS in a referred sample to a specialty clinic. Using a sample of 148 male veterans referred to a Mild Cognitive Impairment (MCI) Clinic for evaluation, the ability of the SLUMS to discriminate between MCI versus Major Depressive Disorder (MDD) or no diagnosis was compared to results from a more comprehensive neuropsychological battery...
September 19, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28925683/3d-nanostructured-palladium-functionalized-graphene-aerogel-supported-fe3o4-for-enhanced-ru-bpy-32-based-electrochemiluminescent-immunosensing-of-prostate-specific-antigen
#3
Lei Yang, Yueyuan Li, Yong Zhang, Dawei Fan, Xuehui Pang, Qin Wei, Bin Du
We developed a novel Ru(bpy)32+-based electrochemiluminescence (ECL) immunosensor utilizing palladium nanoparticles (Pd NPs) functionalized graphene aerogel supported Fe3O4 (FGA-Pd) for real sample analysis of prostate specific antigen (PSA). 3D nanostructured FGA-Pd, as a novel ECL carrier, was prepared by in situ reduction. Large amounts of Ru(bpy)32+ could combine with FGA-Pd via electrostatic interaction to establish a brand-new ECL emitter (Ru@FGA-Pd) for improving ECL efficiency. The obtained Ru@FGA-Pd composite was utilized to label the secondary antibody, which generated strong ECL signals with tripropylamine (TPrA) as coreactant...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28925481/functional-impact-of-galectin-3-and-trail-expression-in-breast-cancer-cells
#4
X-H Liu, C-X Deng, P-C Hu, Y Wang, Y-H Dong
OBJECTIVE: To examine the expression of Galectin-3 and TRAIL in breast cancer tissue and their effects on the proliferation and apoptosis of breast cancer cells. PATIENTS AND METHODS: Breast cancer and normal adjacent tissue were collected from 120 patients pathologically diagnosed with breast cancer who underwent a modified radical mastectomy. SP method of immunohistochemistry was used to detect the expression levels of Galectin-3 and TRAIL in breast cancer tissues and normal adjacent tissues...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28924184/genetic-contributions-to-trail-making-test-performance-in-uk-biobank
#5
S P Hagenaars, S R Cox, W D Hill, G Davies, D C M Liewald, S E Harris, A M McIntosh, C R Gale, I J Deary
The Trail Making Test (TMT) is a widely used test of executive function and has been thought to be strongly associated with general cognitive function. We examined the genetic architecture of the TMT and its shared genetic aetiology with other tests of cognitive function in 23 821 participants from UK Biobank. The single-nucleotide polymorphism-based heritability estimates for trail-making measures were 7.9% (part A), 22.4% (part B) and 17.6% (part B-part A). Significant genetic correlations were identified between trail-making measures and verbal-numerical reasoning (rg>0...
September 19, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28923683/a-hydrogel-matrix-prolongs-persistence-and-promotes-specific-localization-of-an-oncolytic-adenovirus-in-a-tumor-by-restricting-nonspecific-shedding-and-an-antiviral-immune-response
#6
Bo-Kyeong Jung, Eonju Oh, JinWoo Hong, Yunki Lee, Ki Dong Park, Chae-Ok Yun
Currently, intratumoral injection of an oncolytic adenovirus (Ad) is the conventional administration route in clinical trials. Nonetheless, the locally administered Ad disseminates to the surrounding nontarget tissues and has short biological activity due to immunogenicity of Ad, thus necessitating multiple injections to achieve a sufficient therapeutic index. In the present study, a tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-expressing oncolytic Ad (oAd-TRAIL) was encapsulated in a gelatin hydrogel (oAd-TRAIL/gel) to enhance and prolong antitumor efficacy of the virus after a single intratumoral injection...
September 7, 2017: Biomaterials
https://www.readbyqxmd.com/read/28923396/smac-mimetics-and-type-ii-interferon-synergistically-induce-necroptosis-in-various-cancer-cell-lines
#7
Michael John Cekay, Stefanie Roesler, Tanja Frank, Anne-Kathrin Knuth, Ines Eckhardt, Simone Fulda
Since cancer cells often evade apoptosis, induction of necroptosis as another mode of programmed cell death is considered as a promising therapeutic alternative. Here, we identify a novel synergistic interaction of Smac mimetics that antagonize x-linked Inhibitor of Apoptosis (XIAP), cellular Inhibitor of Apoptosis (cIAP) 1 and 2 with interferon (IFN)γ to induce necroptosis in apoptosis-resistant cancer cells in which caspase activation is blocked. The synergistic is confirmed by calculation of combination indices (CIs) and found in both solid and hematological cancer cell lines as well as for different Smac mimetics (i...
September 15, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28922814/the-consul-and-the-beatnik-the-establishment-youth-culture-and-the-beginnings-of-the-hippy-trail-1966-8
#8
Sharif Gemie, Brian Ireland
This paper analyses the attitudes expressed by consular and embassy officials to a new type of traveller they encountered in the mid-1960s. Their observations are contextualised within wider debates concerning 'youth' in the late 1950s and 1960s. Officials distinguished sharply between 'overlanders' (who could be tolerated or accommodated) and 'beatniks' whose behaviour was characterized as illegal and/or unacceptable. Smoking cannabis was identified as a key marker of beatnik behaviour. Officials' observations are contrasted with four accounts by new travellers from the period...
September 1, 2017: 20 Century British History
https://www.readbyqxmd.com/read/28922167/statins-and-cognition-in-parkinson-s-disease
#9
Benjamin L Deck, Jacqueline Rick, Sharon X Xie, Alice Chen-Plotkin, John E Duda, James F Morley, Lana M Chahine, Nabila Dahodwala, John Q Trojanowski, Daniel Weintraub
The relationship between statins and cognition in Parkinson's disease (PD) is poorly understood. Analyses were performed to determine associations between statin use and cross-sectional and longitudinal cognitive performance in PD. Neuropsychological tests, medication logs, and ratings of functional abilities were collected from 313 PD participants longitudinally. At baseline, statin users (SU; N = 129) were older, more likely male, and had shorter PD duration than non-statin users (NSU; N = 184). In Cross-sectional analysis, SU performed better on global cognition, Trails B, semantic fluency, and phonemic fluency tasks...
September 11, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28921464/posttranslational-modification-control-of-inflammatory-signaling
#10
Yibo Si, Yunlu Zhang, Zijuan Chen, Ruixue Zhou, Yihua Zhang, Doudou Hao, Dapeng Yan
Inflammation is usually the defensive reaction of the immune system to the invasion of pathogen and the exogenous objects. The activation of inflammation helps our body to eliminate pathogenic microbe, virus, and parasite harming our health, while under many circumstances inflammation is the direct cause of the pathological damage in tissues and dysfunction of organs. The posttranslational modification (PTM) of the inflammatory pathways, such as TLR pathways, RLR pathways, NLR pathway, intracellular DNA sensors, intracellular RNA sensors, and inflammasomes, is crucial in the regulation of these signaling trails...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28920528/the-diagnostic-accuracy-of-the-montreal-cognitive-assessment-in-inpatient-stroke-rehabilitation
#11
Abhishek Jaywant, Joan Toglia, Faith M Gunning, Michael W O'Dell
The Montreal Cognitive Assessment (MoCA) is a commonly used screening measure for cognitive impairment; however, the diagnostic accuracy and optimal cutoff points in inpatients with mild stroke severity is unknown. We examined the diagnostic accuracy of the MoCA in an acute inpatient stroke rehabilitation unit (N = 95). The criterion neuropsychological assessment was the 30-minute National Institute of Neurological Disorders and Stroke-Canadian Stroke Network battery, modified to include the Symbol-Digit Modalities Test and Trail Making Test A & B...
September 18, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28918539/accelerating-vaccine-development-during-the-2013-2016-west-african-ebola-virus-disease-outbreak
#12
Elizabeth S Higgs, Sheri A Dubey, Beth A G Coller, Jakub K Simon, Laura Bollinger, Robert A Sorenson, Barthalomew Wilson, Martha C Nason, Lisa E Hensley
The Ebola virus disease outbreak that began in Western Africa in December 2013 was unprecedented in both scope and spread, and the global response was slower and less coherent than was optimal given the scale and pace of the epidemic. Past experience with limited localized outbreaks, lack of licensed medical countermeasures, reluctance by first responders to direct scarce resources to clinical research, community resistance to outside interventions, and lack of local infrastructure were among the factors delaying clinical research during the outbreak...
September 17, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28918048/mir-133a-promotes-trail-resistance-in-glioblastoma-via-suppressing-death-receptor-5-and-activating-nf-%C3%AE%C2%BAb-signaling
#13
Shan-Shan Wang, Lu Feng, Bao-Guang Hu, Ying-Fei Lu, Wei-Mao Wang, Wei Guo, Chun-Wai Suen, Bao-Hua Jiao, Jian-Xin Pang, Wei-Ming Fu, Jin-Fang Zhang
Recombinant tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), as a novel cancer therapeutic, is being tested in phase II and III clinical trials; however, TRAIL resistance remains a big obstacle preventing its clinical application. Considering that TRAIL-induced apoptosis through death receptors DR4 and DR5, their activation may be an alternative pathway to suppress TRAIL resistance. In this study, a negative correlation between DR5 expression and TRAIL resistance was observed, and miR-133a was predicted to be the most promising candidate to suppress DR5 expression...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28914952/nanocarriers-for-trail-delivery-driving-trail-back-on-track-for-cancer-therapy
#14
REVIEW
Xu Wu, Shengpeng Wang, Mingxing Li, Anqi Wang, Yangyang Zhou, Peng Li, Yitao Wang
Since its initial identification, tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has been shown to be capable of selectively inducing apoptosis in cancer cells. However, translation of the encouraging preclinical studies of this cytokine into the clinic has been restricted by its extremely short half-life, the presence of resistant cancer cell populations, and its inefficient in vivo delivery. Recently, there has been exceptional progress in developing novel formulations to increase the circulatory half-life of TRAIL and new combinations to treat cancers that are resistant to TRAIL...
September 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/28914577/unbalanced-vitreous-levels-of-osteoprotegerin-rankl-rank-and-trail-in-proliferative-diabetic-retinopathy
#15
Ahmed M Abu El-Asrar, Ajmal Ahmad, Kaiser Alam, Emilie Bittoun, Mohammad Mairaj Siddiquei, Ghulam Mohammad, Ahmed Mousa, Gert De Hertogh, Ghislain Opdenakker
PURPOSE: We investigated the expression of the proinflammatory and proangiogenic factor osteoprotegerin (OPG) and its ligands, receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), and the receptor RANK in proliferative diabetic retinopathy (PDR). MATERIALS AND METHODS: Vitreous samples from PDR and nondiabetic control patients and epiretinal membranes from PDR patients were studied by enzyme-linked immunosorbent assay, immunohistochemistry, and Western blot analysis...
September 15, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28912765/biology-and-genomics-of-an-historic-therapeutic-escherichia-coli-bacteriophage-collection
#16
Abiyad Baig, Joan Colom, Paul Barrow, Catherine Schouler, Arshnee Moodley, Rob Lavigne, Robert Atterbury
We have performed microbiological and genomic characterization of an historic collection of nine bacteriophages, specifically infecting a K1 E. coli O18:K1:H7 ColV(+) strain. These phages were isolated from sewage and tested for their efficacy in vivo for the treatment of systemic E. coli infection in a mouse infection model by Smith and Huggins (1982). The aim of the study was to identify common microbiological and genomic characteristics, which co-relate to the performance of these phages in in vivo study...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28912737/neuropsychological-profile-of-specific-executive-dysfunctions-in-patients-with-deficit-and-non-deficit-schizophrenia
#17
Ernest Tyburski, Justyna Pełka-Wysiecka, Monika Mak, Agnieszka Samochowiec, Przemysław Bieńkowski, Jerzy Samochowiec
Objectives: Although it has been shown that there are more profound deficits present in deficit schizophrenia (DS) patients than in non-deficit schizophrenia (NDS) patients, there still remain some matters requiring further investigation. In this context, we formulated three research aims: (1) to compare executive functions between the investigated groups, (2) to determine the relationship between particular aspects of executive functions within the groups, and (3) to draw up a neuropsychological profile for executive functions...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28910322/social-interactions-promote-adaptive-resource-defense-in-ants
#18
Christoph Johannes Kleineidam, Eva Linda Heeb, Stefanie Neupert
Social insects vigorously defend their nests against con- and heterospecific competitors. Collective defense is also seen at highly profitable food sources. Aggressive responses are elicited or promoted by several means of communication, e.g. alarm pheromones and other chemical markings. In this study, we demonstrate that the social environment and interactions among colony members (nestmates) modulates the propensity to engage in aggressive behavior and therefore plays an important role in allocating workers to a defense task...
2017: PloS One
https://www.readbyqxmd.com/read/28906542/illuminating-the-pathway-for-the-next-generation-of-cardiovascular-medicine-practitioners-and-researchers-highlights-of-the-joint-pascar-scc-clinical-symposium-on-hypertension-and-heart-failure-cameroon
#19
Martin H Abanda, Anastase Dzudie, Ba Hamadou, Yves Monkam, Henry Luma, Marie Solange Douala, Loryane Nganhyim, Bonaventure S Dzekem, Theophile N Nana, George Nel, Ana O Mocumbi, Simon Stewart, Karen Sliwa, Eugene Belley Priso
The Pan-African Society of Cardiology roadmap aims to achieve a 25% control of hypertension by the year 2025. Whether this is attainable or not depends largely on the capacity of healthcare providers and policy makers to address the rising prevalence of hypertension and its complications, including heart failure. Task sharing is fundamental in optimising hypertension control. The Clinical Research Education, Networking and Consultancy (CRENC) engaged with the Pan-African Society of Cardiology (PASCAR) and the Cameroon Cardiac Society (SCC) in a joint hypertension and heart failure symposium at the Douala General Hospital in 2016...
July 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28904971/cognitive-or-cognitive-motor-executive-function-tasks-evaluating-verbal-fluency-measures-in-people-with-parkinson-s-disease
#20
Alessandra Ferreira Barbosa, Mariana Callil Voos, Janini Chen, Debora Cristina Valente Francato, Carolina de Oliveira Souza, Egberto Reis Barbosa, Hsin Fen Chien, Letícia Lessa Mansur
INTRODUCTION: Executive function deficits are observed in people with Parkinson's disease (PD) from early stages and have great impact on daily living activities. Verbal fluency and oral diadochokinesia involve phonarticulatory coordination, response inhibition, and phonological processing and may also be affected in people with PD. This study aimed to describe the performance of PD patients and an age- and education-matched control group on executive function, verbal fluency, and oral diadochokinesia tests and to investigate possible relationships between them...
2017: BioMed Research International
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