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https://www.readbyqxmd.com/read/28231336/comparison-of-neurological-health-outcomes-between-two-adolescent-cohorts-exposed-to-pesticides-in-egypt
#1
Ahmed A Ismail, Matthew R Bonner, Olfat Hendy, Gaafar Abdel Rasoul, Kai Wang, James R Olson, Diane S Rohlman
Pesticide-exposed adolescents may have a higher risk of neurotoxic effects because of their developing brains and bodies. However, only a limited number of studies have addressed this risk among adolescents. The aim of this study was to compare neurological outcomes from two cohorts of Egyptian adolescents working as pesticide applicators. In 2005 and 2009, two cohorts of male adolescents working as pesticide applicators for the cotton crop were recruited from Menoufia Governorate, Egypt. The same application schedule and pesticides were used at both times, including both organophosphorus, and pyrethroid compounds...
2017: PloS One
https://www.readbyqxmd.com/read/28230655/lessons-learned-from-human-hiv-vaccine-trials
#2
Justin Pollara, David Easterhoff, Genevieve G Fouda
PURPOSE OF REVIEW: The ability to induce broadly neutralizing antibody (bNAb) responses is likely essential for development of a globally effective HIV vaccine. Unfortunately, human vaccine trials conducted to date have failed to elicit broad plasma neutralization of primary virus isolates. Despite this limitation, in-depth analysis of the vaccine-induced memory B-cell repertoire can provide valuable insights into the presence and function of subdominant B-cell responses, and identify initiation of antibody lineages that may be on a path towards development of neutralization breadth...
February 21, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28230419/the-association-between-physical-performance-and-executive-function-in-a-sample-of-rural-older-adults-from-south-carolina-usa
#3
Ryan S Falck, Sara Wilcox, John R Best, Jessica L Chandler, Teresa Liu-Ambrose
BACKGROUND: Mobility and executive functions (EFs) decline with age, although associations between mobility and EFs are less clear. This study examined relationships between different mobility measures and EFs among rural older adults. METHODS: This cross-sectional study recruited 56 older adults (60+ years) in rural South Carolina. Mobility was assessed via gait speed, timed up-and-go, chair stand, and as a composite physical performance score (PPS). EFs was assessed via Trail Making Test, semantic fluency, and phonemic fluency...
March 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28229986/executive-function-training-for-children-with-attention-deficit-hyperactivity-disorder
#4
Lan Shuai, David Daley, Yu-Feng Wang, Jin-Song Zhang, Yan-Ting Kong, Xin Tan, Ning Ji
BACKGROUND: Accumulating evidence indicates that attention deficit hyperactivity disorder (ADHD) is associated with core deficits in executive function (EF) which predicts poorer academic and occupational functioning. This makes early intervention targeting EF impairments important to prevent long-term negative outcomes. Cognitive training is a potential ADHD treatment target. The present study aimed to explore the efficacy, feasibility, and acceptability of a cognitive training program (targeting child's multiple EF components and involving parent support in daily life), as a nonpharmacological intervention for children with ADHD...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28229372/measuring-inhibition-and-cognitive-flexibility-in-friedreich-ataxia
#5
Louise A Corben, Felicity Klopper, Monique Stagnitti, Nellie Georgiou-Karistianis, John L Bradshaw, Gary Rance, Martin B Delatycki
Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder with subtle impact on cognition. Inhibitory processes and cognitive flexibility were examined in FRDA by assessing the ability to suppress a predictable verbal response. We administered the Hayling Sentence Completion Test (HSCT), the Trail Making Test, and the Stroop Test to 43 individuals with FRDA and 42 gender- and age-matched control participants. There were no significant group differences in performance on the Stroop or Trail Making Test whereas significant impairment in cognitive flexibility including the ability to predict and inhibit a pre-potent response as measured in the HSCT was evident in individuals with FRDA...
February 22, 2017: Cerebellum
https://www.readbyqxmd.com/read/28228567/prolonged-sleep-duration-as-a-marker-of-early-neurodegeneration-predicting-incident-dementia
#6
Andrew J Westwood, Alexa Beiser, Nikita Jain, Jayandra J Himali, Charles DeCarli, Sanford H Auerbach, Matthew P Pase, Sudha Seshadri
OBJECTIVE: To evaluate the association between sleep duration and the risk of incident dementia and brain aging. METHODS: Self-reported total hours of sleep were examined in the Framingham Heart Study (n = 2,457, mean age 72 ± 6 years, 57% women) as a 3-level variable: <6 hours (short), 6-9 hours (reference), and >9 hours (long), and was related to the risk of incident dementia over 10 years, and cross-sectionally to total cerebral brain volume (TCBV) and cognitive performance...
February 22, 2017: Neurology
https://www.readbyqxmd.com/read/28228218/-thioridazine-sensitizes-apoptotic-effect-of-trail-in-human-lung-cancer-pc9-cells-through-er-stress-mediated-up-regulation-of-dr5
#7
Juan Li, Yi Wang, Liu Liu, Yuan Yuan, Yangyi Bao
BACKGROUND: Tumor necrosis factor-related apoptosis-inducting ligand (TRAIL) can induce apoptosis of tumor cells, however, various of tumor cells may survive because of resistance to TRAIL-mediated apoptosis. This study is to observe the proliferation inhibition effect of TRAIL sensitized by thioridazine on PC9 cells through endoplasmic reticulum (ER) stress mediated up-regulation of death receptor 5 (DR5) and investigate its mechanism. METHODS: PC9 cells were treated with different concentrations of thioridazine and TRAIL alone or in combination...
February 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28227828/pose-measurement-of-anterior-pelvic-plane-based-on-inertial-measurement-unit-in-total-hip-replacement-surgeries
#8
Zhe Cao, Shaojie Su, Hong Chen, Hao Tang, Yixin Zhou, Zhihua Wang, Zhe Cao, Shaojie Su, Hong Chen, Hao Tang, Yixin Zhou, Zhihua Wang, Zhe Cao, Yixin Zhou, Hong Chen, Zhihua Wang, Hao Tang, Shaojie Su
In Total Hip Replacement (THR), inaccurate measurement of Anterior Pelvic Plane (APP), which is usually used as a reference plane, will lead to malposition of the acetabular prosthesis. As a result, the risk of impingement, dislocation and wear will increase and the safe range of motion will be limited. In order to acquire the accurate pose of APP, a measurement system is designed in this paper, which includes two parts: one is used to estimate the initial pose of APP and the other is used to trail dynamic motion of APP...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227144/optimal-medication-dosing-from-suboptimal-clinical-examples-a-deep-reinforcement-learning-approach
#9
Shamim Nemati, Mohammad M Ghassemi, Gari D Clifford, Shamim Nemati, Mohammad M Ghassemi, Gari D Clifford, Gari D Clifford, Mohammad M Ghassemi
Misdosing medications with sensitive therapeutic windows, such as heparin, can place patients at unnecessary risk, increase length of hospital stay, and lead to wasted hospital resources. In this work, we present a clinician-in-the-loop sequential decision making framework, which provides an individualized dosing policy adapted to each patient's evolving clinical phenotype. We employed retrospective data from the publicly available MIMIC II intensive care unit database, and developed a deep reinforcement learning algorithm that learns an optimal heparin dosing policy from sample dosing trails and their associated outcomes in large electronic medical records...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226263/comparing-impacts-between-formal-and-informal-recreational-trails
#10
Catherine Marina Pickering, Patrick Norman
Globally there are hundreds of thousands of kilometres of recreational trails traversing natural areas of high conservation value: but what are their impacts and do impacts differ among trails? We compared the effects of four common types of recreational trails [(1) narrow and (2) medium width informal bare earth trails and (3) gravel and (4) tarmac/concrete formal trails] on vegetation adjacent to trails in a high conservation value plant community that is popular for mountain biking and hiking in Australia...
February 19, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28225020/improved-antitumor-activity-of-trail-fusion-protein-via-formation-of-self-assembling-nanoparticle
#11
Kaizong Huang, Ningjun Duan, Chunmei Zhang, Ran Mo, Zichun Hua
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been known as a promising agent for cancer therapy due to its specific apoptosis-inducing effect on tumor cells rather than most normal cells. However, systemically delivered TRAIL suffers from a rapid clearance from the body with an extremely short half-life. Thermally responsive elastin-like polypeptides (ELPs) are a promising class of temperature sensitive biopolymers based on the structural motif found in mammalian tropoelastin and retain the advantages of polymeric drug delivery systems...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28223543/role-of-caspases-in-cd95-induced-biphasic-activation-of-acid-sphingomyelinase
#12
Mario Stephan, Bärbel Edelmann, Supandi Winoto-Morbach, Ottmar Janssen, Uwe Bertsch, Cristiana Perrotta, Stefan Schütze, Jürgen Fritsch
Acid sphingomyelinase (A-SMase) plays an important role in the initiation of CD95 signaling by forming ceramide-enriched membrane domains that enable clustering and activation of the death receptors. In TNF-R1 and TRAIL-R1/R2 signaling, A-SMase also contributes to the lysosomal apoptosis pathway triggered by receptor internalization. Here, we investigated the molecular mechanism of CD95-mediated A-SMase activation, demonstrating that A-SMase is located in internalized CD95-receptosomes and is activated by the CD95/CD95L complex in a biphasic manner...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28218726/biomarkers-in-pediatric-community-acquired-pneumonia
#13
REVIEW
Nicola Principi, Susanna Esposito
Community-acquired pneumonia (CAP) is an infectious disease caused by bacteria, viruses, or a combination of these infectious agents. The severity of the clinical manifestations of CAP varies significantly. Consequently, both the differentiation of viral from bacterial CAP cases and the accurate assessment and prediction of disease severity are critical for effectively managing individuals with CAP. To solve questionable cases, several biomarkers indicating the etiology and severity of CAP have been studied...
February 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28218592/using-serial-trichotomization-with-common-cognitive-tests-to-screen-for-fitness-to-drive
#14
Carrie Gibbons, Nathan Smith, Randy Middleton, John Clack, Bruce Weaver, Sacha Dubois, Michel Bédard
OBJECTIVE: The aim of this study was to illustrate the use of serial trichotomization with five common tests of cognition to achieve greater precision in screening for fitness to drive. METHOD: We collected data (using the Montreal Cognitive Assessment, Motor-Free Visual Perception Test, Clock-Drawing Test, Trail Making Test Part A and B [Trails B], and an on-road driving test) from 83 people referred for a driving evaluation. We identified cutpoints for 100% sensitivity and specificity for each test; the driving test was the gold standard...
March 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28215385/research-to-practice-implementing-physical-activity-recommendations
#15
Sally M Davis, Theresa H Cruz, Richard L Kozoll
INTRODUCTION: Dissemination and implementation science focuses on bridging the gap between research and practice. The Community Preventive Services Task Force published recommendations for increasing physical activity based on scientific review and consensus. Little research on the dissemination and implementation of these recommendations has been conducted in under-represented populations at high risk for inactivity and chronic disease. METHODS: Partnering with one rural community (beta site), the University of New Mexico Prevention Research Center studied the translation of Community Preventive Services Task Force recommendations to practice...
March 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28214008/recovery-of-salt-marsh-vegetation-after-removal-of-storm-deposited-anthropogenic-debris-lessons-from-volunteer-clean-up-efforts-in-long-beach-ny
#16
Kaitlin M Ehl, Steve M Raciti, Jason D Williams
Recovery of vegetation on a Long Island, NY salt marsh was investigated after the removal of hurricane-deposited large wooden debris through managed clean-ups involving volunteers. Two years after the removal of the debris, vegetation cover and species composition were not significantly different from controls. There was no significant difference in vegetation recovery among fall and spring debris removal treatments. Initial vegetation cover of the experimental and control plots was 95.8% and 1.2%, respectively; after two growing seasons cover was 78...
February 14, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28212978/a-systematic-review-of-the-survival-and-complication-rates-of-inlay-retained-fixed-dental-prostheses
#17
REVIEW
Junyu Chen, He Cai, Lai Suo, Yiyuan Xue, Jian Wang, Qianbing Wan
OBJECTIVES: The aim of this systematic review was to investigate the survival and complication rates of inlay-retainer fixed dental prostheses (IRFDPs). DATA/SOURCES: A systematic search was conducted in the PubMed, EMBASE, and Cochrane Library databases in English and time filters (articles published from 1960) were used. STUDY SELECTION: Randomized controlled trails (RCTs), controlled clinical trials (CCTs) and prospective cohort studies on IRFDPs with a mean follow-up period of at least 2 years were included...
February 14, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28212753/the-trail-induced-cancer-secretome-promotes-a-tumor-supportive-immune-microenvironment-via-ccr2
#18
Torsten Hartwig, Antonella Montinaro, Silvia von Karstedt, Alexandra Sevko, Silvia Surinova, Ankur Chakravarthy, Lucia Taraborrelli, Peter Draber, Elodie Lafont, Frederick Arce Vargas, Mona A El-Bahrawy, Sergio A Quezada, Henning Walczak
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known for specifically killing cancer cells, whereas in resistant cancers, TRAIL/TRAIL-R can promote metastasis via Rac1 and PI3K. It remains unknown, however, whether and to what extent TRAIL/TRAIL-R signaling in cancer cells can affect the immune microenvironment. Here we show that TRAIL-triggered cytokine secretion from TRAIL-resistant cancer cells is FADD dependent and identify the TRAIL-induced secretome to drive monocyte polarization to myeloid-derived suppressor cells (MDSCs) and M2-like macrophages...
February 16, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28212752/caspase-8-acts-in-a-non-enzymatic-role-as-a-scaffold-for-assembly-of-a-pro-inflammatory-faddosome-complex-upon-trail-stimulation
#19
Conor M Henry, Seamus J Martin
TRAIL is a potent inducer of apoptosis and has been studied almost exclusively in this context. However, TRAIL can also induce NFκB-dependent expression of multiple pro-inflammatory cytokines and chemokines. Surprisingly, whereas inhibition of caspase activity blocked TRAIL-induced apoptosis, but not cytokine production, knock down or deletion of caspase-8 suppressed both outcomes, suggesting that caspase-8 participates in TRAIL-induced inflammatory signaling in a scaffold role. Consistent with this, introduction of a catalytically inactive caspase-8 mutant into CASP-8 null cells restored TRAIL-induced cytokine production, but not cell death...
February 16, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28212746/jekyll-hyde-the-other-life-of-the-death-ligand-trail
#20
Najoua Lalaoui, John Silke
Henry and Martin (2017) and Hartwig et al. (2017) provide more insights into the non-apoptotic function of the FADD/caspase-8 duo in TRAIL signaling.
February 16, 2017: Molecular Cell
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