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Simon Brooker

Simon J Brooker
No abstract text is available yet for this article.
April 16, 2018: Lancet Infectious Diseases
Dawn Brooker, Simon Evans, Shirley Evans, Jennifer Bray, Francesca Lea Saibene, Claudia Scorolli, Dorota Szcześniak, Alessia d'Arma, Katarzyna M Urbańska, Teresa Atkinson, Elisabetta Farina, Joanna Rymaszewska, Rabih Chattat, Catherine Henderson, Amritpal Rehill, Iris Hendriks, Franka Meiland, Rose-Marie Dröes
OBJECTIVES: MEETINGDEM investigated whether the Dutch Meeting Centres Support Programme (MCSP) could be implemented in Italy, Poland, and the UK with comparable benefits. This paper reports on the impact on people living with dementia attending pilot Meeting Centres in the 3 countries. METHODS: Nine pilot Meeting Centres (MCs) participated (Italy-5, Poland-2, UK-2). Effectiveness of MCSP was compared with Usual Care (UC) on outcomes measuring behavioural and psychological symptoms (NPI), depression (CSDD), and quality of life (DQoL, QOL-AD), analysed by ANCOVAs in a 6-month pre-test/post-test controlled trial...
March 7, 2018: International Journal of Geriatric Psychiatry
Mark D Lim, Simon J Brooker, Vicente Y Belizario, Françoise Gay-Andrieu, John Gilleard, Bruno Levecke, Lisette van Lieshout, Graham F Medley, Zeleke Mekonnen, Greg Mirams, Sammy M Njenga, Maurice R Odiere, James W Rudge, Lieven Stuyver, Jozef Vercruysse, Johnny Vlaminck, Judd L Walson
No abstract text is available yet for this article.
March 2018: PLoS Neglected Tropical Diseases
Dorota Szcześniak, Rose-Marie Dröes, Franka Meiland, Dawn Brooker, Elisabetta Farina, Rabih Chattat, Shirley B Evans, Simon C Evans, Francesca Lea Saibene, Katarzyna Urbańska, Joanna Rymaszewska
BACKGROUND: The "pathway to care" concept offers a helpful framework for preparing national dementia plans and strategies and provides a structure to explore the availability and accessibility of timely and effective care for people with dementia and support for their informal carers. Within the framework of the JPND-MEETINGDEM implementation project the pathways to regular day-care activities and the Meeting Centers Support Programme (MCSP), an innovative combined support form for people with dementia and carers, was explored...
February 13, 2018: International Psychogeriatrics
Kebede Deribe, Amuam Andrew Beng, Jorge Cano, Abdel Jelil Njouendo, Jerome Fru-Cho, Abong Raphael Awah, Mathias Esum Eyong, Patrick W Chounna Ndongmo, Emanuele Giorgi, David M Pigott, Nick Golding, Rachel L Pullan, Abdisalan M Noor, Fikre Enquselassie, Christopher J L Murray, Simon J Brooker, Simon I Hay, Peter Enyong, Melanie J Newport, Samuel Wanji, Gail Davey
BACKGROUND: Podoconiosis is a non-filarial elephantiasis, which causes massive swelling of the lower legs. It was identified as a neglected tropical disease by WHO in 2011. Understanding of the geographical distribution of the disease is incomplete. As part of a global mapping of podoconiosis, this study was conducted in Cameroon to map the distribution of the disease. This mapping work will help to generate data on the geographical distribution of podoconiosis in Cameroon and contribute to the global atlas of podoconiosis...
January 2018: PLoS Neglected Tropical Diseases
Kebede Deribe, Jorge Cano, Emanuele Giorgi, David M Pigott, Nick Golding, Rachel L Pullan, Abdisalan M Noor, Elizabeth A Cromwell, Aaron Osgood-Zimmerman, Fikre Enquselassie, Asrat Hailu, Christopher J L Murray, Melanie J Newport, Simon J Brooker, Simon I Hay, Gail Davey
BACKGROUND: In 2011, the World Health Organization recognized podoconiosis as one of the neglected tropical diseases. Nonetheless, the number of people with podoconiosis and the geographical distribution of the disease is poorly understood. Based on a nationwide mapping survey and geostatistical modelling, we predict the prevalence of podoconiosis and estimate the number of cases across Ethiopia. METHODS: We used nationwide data collected in Ethiopia between 2008 and 2013...
2017: Wellcome Open Research
Siân E Clarke, Saba Rouhani, Seybou Diarra, Renion Saye, Modibo Bamadio, Rebecca Jones, Diahara Traore, Klenon Traore, Matthew Ch Jukes, Josselin Thuilliez, Simon Brooker, Natalie Roschnik, Moussa Sacko
BACKGROUND: School-aged children are rarely targeted by malaria control programmes, yet the prevalence of Plasmodium infection in primary school children often exceeds that seen in younger children and could affect haemoglobin concentration and school performance. METHODS: A cluster-randomised trial was carried out in 80 primary schools in southern Mali to evaluate the impact of a school-based malaria intervention package. Intervention schools received two interventions sequentially: (1) teacher-led participatory malaria prevention education, combined with distribution of long-lasting insecticidal nets (LLINs), followed 7 months later at the end of the transmission season by (2) mass delivery of artesunate and sulfadoxine-pyrimethamine administered by teachers, termed intermittent parasite clearance in schools (IPCs)...
2017: BMJ Global Health
Roberta Maccario, Saba Rouhani, Tom Drake, Annie Nagy, Modibo Bamadio, Seybou Diarra, Souleymane Djanken, Natalie Roschnik, Siân E Clarke, Moussa Sacko, Simon Brooker, Josselin Thuilliez
BACKGROUND: The expansion of malaria prevention and control to school-aged children is receiving increasing attention, but there are still limited data on the costs of intervention. This paper analyses the costs of a comprehensive school-based intervention strategy, delivered by teachers, that included participatory malaria educational activities, distribution of long lasting insecticide-treated nets (LLIN), and Intermittent Parasite Clearance in schools (IPCs) in southern Mali. METHODS: Costs were collected alongside a randomised controlled trial conducted in 80 primary schools in Sikasso Region in Mali in 2010-2012...
June 12, 2017: BMC Public Health
Rajiv Sarkar, Anuradha Rose, Venkata R Mohan, Sitara S R Ajjampur, Vasanthakumar Veluswamy, Rajan Srinivasan, Jayaprakash Muliyil, Vedantam Rajshekhar, Kuryan George, Vinohar Balraj, Nicholas C Grassly, Roy M Anderson, Simon J Brooker, Gagandeep Kang
INTRODUCTION: Hookworm infection is a leading cause of iron deficiency anemia and malnutrition in resource-poor settings. Periodic mass deworming with anthelminthic drugs remains the cornerstone of hookworm control efforts worldwide. Reinfection following treatment occurs, reflecting the human host's inability to acquire immunity following exposure to an untreated reservoir of infection. This cluster randomized trial will evaluate the effectiveness of a modified, population-based, mass deworming strategy in reducing hookworm infection in an endemic southern Indian population...
March 2017: Contemporary Clinical Trials Communications
Kebede Deribe, Jorge Cano, Melanie J Newport, Rachel L Pullan, Abdisalan M Noor, Fikre Enquselassie, Christopher J L Murray, Simon I Hay, Simon J Brooker, Gail Davey
No abstract text is available yet for this article.
May 2017: Lancet Global Health
Sammy M Njenga, Henry M Kanyi, Faith M Mutungi, Collins Okoyo, Hadley S Matendechero, Rachel L Pullan, Katherine E Halliday, Simon J Brooker, C Njeri Wamae, Joyce K Onsongo, Kimberly Y Won
BACKGROUND: Lymphatic filariasis (LF) is a debilitating disease associated with extensive disfigurement and is one of a diverse group of diseases referred to as neglected tropical diseases (NTDs) which mainly occur among the poorest populations. In line with global recommendations to eliminate LF, Kenya launched its LF elimination programme in 2002 with the aim to implement annual mass drug administration (MDA) in order to interrupt LF transmission. However, the programme faced financial and administrative challenges over the years such that sustained annual MDA was not possible...
February 22, 2017: Parasites & Vectors
Stella Kepha, Charles S Mwandawiro, Roy M Anderson, Rachel L Pullan, Fred Nuwaha, Jorge Cano, Sammy M Njenga, Maurice R Odiere, Elizabeth Allen, Simon J Brooker, Birgit Nikolay
BACKGROUND: School-based deworming is widely implemented in various countries to reduce the burden of soil-transmitted helminths (STHs), however, the frequency of drug administration varies in different settings. In this study, we compared the impact of a single annual treatment and 4-monthly treatment over a follow-up among Kenyan school children, and investigated the factors associated with residual infection. METHODS: We performed a secondary analysis of data from a randomized trial investigating whether deworming for STHs alters risk of acquiring malaria...
February 9, 2017: Infectious Diseases of Poverty
Collins Okoyo, Birgit Nikolay, Jimmy Kihara, Elses Simiyu, Joshua V Garn, Mathew C Freeman, Mariam T Mwanje, Dunstan A Mukoko, Simon J Brooker, Rachel L Pullan, Sammy M Njenga, Charles S Mwandawiro
BACKGROUND: In 2012, the Kenyan Ministries of Health and of Education began a programme to deworm all school-age children living in areas at high risk of soil-transmitted helminths (STH) and schistosome infections. The impact of this school-based mass drug administration (MDA) programme in Kenya is monitored by the Kenya Medical Research Institute (KEMRI) as part of a five-year (2012-2017) study. This article focuses on the impact of MDA on STH infections and presents the overall achieved reductions from baseline to mid-term, as well as yearly patterns of reductions and subsequent re-infections per school community...
July 25, 2016: Parasites & Vectors
Hugo C Turner, James E Truscott, Alison A Bettis, T Déirdre Hollingsworth, Simon J Brooker, Roy M Anderson
INTRODUCTION: Soil-transmitted helminth (STH) infections are predominately controlled by providing children with preventive chemotherapy with either albendazole or mebendazole. However, neither has a high efficacy against Trichuris trichiura. This low efficacy limits the overall effectiveness of the current STH control programmes against T. trichiura. It has been demonstrated that co-administering ivermectin with albendazole or mebendazole significantly increases the efficacy of current treatments, which may increase the overall effectiveness of control programmes...
June 2016: Parasite Epidemiology and Control
Joaniter I Nankabirwa, Melissa D Conrad, Jennifer Legac, Stephen Tukwasibwe, Patrick Tumwebaze, Bonnie Wandera, Simon J Brooker, Sarah G Staedke, Moses R Kamya, Sam L Nsobya, Grant Dorsey, Philip J Rosenthal
Dihydroartemisinin-piperaquine (DP) offers prolonged protection against malaria, but its impact on Plasmodium falciparum drug sensitivity is uncertain. In a trial of intermittent preventive treatment in schoolchildren in Tororo, Uganda, in 2011 to 2012, monthly DP for 1 year decreased the incidence of malaria by 96% compared to placebo; DP once per school term offered protection primarily during the first month after therapy. To assess the impact of DP on selection of drug resistance, we compared the prevalence of key polymorphisms in isolates that emerged at different intervals after treatment with DP...
October 2016: Antimicrobial Agents and Chemotherapy
Michael A Irvine, Sammy M Njenga, Shamini Gunawardena, Claire Njeri Wamae, Jorge Cano, Simon J Brooker, T Deirdre Hollingsworth
No abstract text is available yet for this article.
May 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
Stella Kepha, Birgit Nikolay, Fred Nuwaha, Charles S Mwandawiro, Joaniter Nankabirwa, Juliet Ndibazza, Jorge Cano, Damaris Matoke-Muhia, Rachel L Pullan, Elizabeth Allen, Katherine E Halliday, Simon J Brooker
BACKGROUND: Malaria among school children is increasingly receiving attention, yet the burden of malaria in this age group is poorly defined. This study presents data on malaria morbidity among school children in Bungoma county, western Kenya. METHOD: This study investigated the burden and risk factors of Plasmodium falciparum infection, clinical malaria, and anaemia among 2346 school children aged 5-15 years, who were enrolled in an individually randomized trial evaluating the effect of anthelmintic treatment on the risks of malaria...
March 11, 2016: Malaria Journal
Joshua V Garn, Charles S Mwandawiro, Birgit Nikolay, Carolyn D Drews-Botsch, Jimmy H Kihara, Simon J Brooker, Elses W Simiyu, Collins Okoyo, Matthew C Freeman
Water, sanitation, and hygiene (WaSH) technologies and behaviors can prevent infection by soil-transmitted helminth species independently, but may also interact in complex ways. However, these interactions are poorly understood. The purpose of this study was to characterize how school and home WaSH exposures were associated with Ascaris lumbricoides infection and to identify relevant interactions between separate WaSH technologies and behaviors. A study was conducted among 4,404 children attending 51 primary schools in western Kenya...
May 4, 2016: American Journal of Tropical Medicine and Hygiene
Hugo C Turner, James E Truscott, Fiona M Fleming, T Déirdre Hollingsworth, Simon J Brooker, Roy M Anderson
BACKGROUND: The coverage of mass drug administration (MDA) for neglected tropical diseases, such as the soil-transmitted helminths (STHs), needs to rapidly expand to meet WHO's 2020 targets. We aimed to compare use of a cost function to take into account economies of scale to the standard method of assuming a constant cost per treatment when investigating the cost and cost-effectiveness of scaling up a STH MDA programme targeting Ascaris lumbricoides. METHODS: We fitted a cost function describing how the costs of MDA change with scale to empirical cost data and incorporated it into a STH transmission model...
July 2016: Lancet Infectious Diseases
Michael A Irvine, Sammy M Njenga, Shamini Gunawardena, Claire Njeri Wamae, Jorge Cano, Simon J Brooker, T Deirdre Hollingsworth
BACKGROUND: Lymphatic filariasis is a debilitating neglected tropical disease that affects impoverished communities. Rapid diagnostic tests of antigenaemia are a practical alternative to parasitological tests of microfilaraemia for mapping and surveillance. However the relationship between these two methods of measuring burden has previously been difficult to interpret. METHODS: A statistical model of the distribution of worm burden and microfilariae (mf) and resulting antigenaemic and mf prevalence was developed and fitted to surveys of two contrasting sentinel sites undergoing interventions...
February 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
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