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https://www.readbyqxmd.com/read/29451895/metabolic-enzyme-cost-explains-variable-trade-offs-between-microbial-growth-rate-and-yield
#1
Meike T Wortel, Elad Noor, Michael Ferris, Frank J Bruggeman, Wolfram Liebermeister
Microbes may maximize the number of daughter cells per time or per amount of nutrients consumed. These two strategies correspond, respectively, to the use of enzyme-efficient or substrate-efficient metabolic pathways. In reality, fast growth is often associated with wasteful, yield-inefficient metabolism, and a general thermodynamic trade-off between growth rate and biomass yield has been proposed to explain this. We studied growth rate/yield trade-offs by using a novel modeling framework, Enzyme-Flux Cost Minimization (EFCM) and by assuming that the growth rate depends directly on the enzyme investment per rate of biomass production...
February 16, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29440715/effect-of-mitochondrial-uncouplers-niclosamide-ethanolamine-nen-and-oxyclozanide-on-hepatic-metastasis-of-colon-cancer
#2
Amer Alasadi, Michael Chen, G V T Swapna, Hanlin Tao, Jingjing Guo, Juan Collantes, Noor Fadhil, Gaetano T Montelione, Shengkan Jin
Metabolism of cancer cells is characterized by aerobic glycolysis, or the Warburg effect. Aerobic glycolysis reduces pyruvate flux into mitochondria, preventing a complete oxidation of glucose and shunting glucose to anabolic pathways essential for cell proliferation. Here we tested a new strategy, mitochondrial uncoupling, for its potential of antagonizing the anabolic effect of aerobic glycolysis and for its potential anticancer activities. Mitochondrial uncoupling is a process that facilitates proton influx across the mitochondrial inner membrane without generating ATP, stimulating a futile cycle of acetyl- CoA oxidation...
February 13, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29439033/genome-sequence-of-serratia-marcescens-subsp-sakuensis-strain-k27-a-marine-bacterium-isolated-from-sponge-haliclona-amboinensis
#3
Tzi Him Cheng, Jasnizat Saidin, Muhd Danish-Daniel, Han Ming Gan, Mohd Noor Mat Isa, Mohd Faizal Abu Bakar, Noraznawati Ismail
Serratia marcescens subsp. sakuensis strain K27 was isolated from sponge ( Haliclona amboinensis ). The genome of this strain consists of 5,325,727 bp, with 5,140 open reading frames (ORFs), 3 rRNAs, and 67 tRNAs. It contains genes for the production of amylases, lipases, and proteases. Gene clusters for the biosynthesis of nonribosomal peptides and thiopeptide were also identified.
February 8, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29438291/the-effect-of-n-terminal-domain-removal-towards-the-biochemical-and-structural-features-of-a-thermotolerant-lipase-from-an-antarctic-pseudomonas-sp-strain-ams3
#4
Wahhida Latip, Raja Noor Zaliha Raja Abd Rahman, Adam Thean Chor Leow, Fairolniza Mohd Shariff, Nor Hafizah Ahmad Kamarudin, Mohd Shukuri Mohamad Ali
Lipase plays an important role in industrial and biotechnological applications. Lipases have been subject to modification at the N and C terminals, allowing better understanding of lipase stability and the discovery of novel properties. A thermotolerant lipase has been isolated from Antarctic Pseudomonas sp. The purified Antarctic AMS3 lipase (native) was found to be stable across a broad range of temperatures and pH levels. The lipase has a partial Glutathione- S -transferase type C (GST-C) domain at the N-terminal not found in other lipases...
February 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29433980/fatty-infiltration-and-muscle-atrophy-of-the-rotator-cuff-in-stemless-total-shoulder-arthroplasty-a-prospective-cohort-study
#5
Arkan S Sayed-Noor, Raymond Pollock, Bassem T Elhassan, Bakir Kadum
BACKGROUND: The influence of preoperative rotator cuff fatty infiltration (FI) and muscle atrophy (MA) on the postoperative outcome of total shoulder arthroplasty (TSA) has only rarely been investigated and reported in the literature. We hypothesized that more FI and MA would be associated with a worse postoperative functional outcome. METHODS: This prospective cohort study included 63 patients (31 female and 32 male patients; mean age, 71 years [range, 53-89 years; standard deviation, 7 years]) with primary osteoarthritis of the shoulder operated on with anatomic stemless TSA...
February 9, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29433011/cling-film-plastic-wrap-an-innovation-for-dead-body-packaging-preservation-and-transportation-by-first-responders-as-a-replacement-for-cadaver-body-bag-in-large-scale-disasters
#6
Lay See Khoo, Poh Soon Lai, Mohd Hilmi Saidin, Zahari Noor, Mohd Shah Mahmood
Cadaver body bags are the conventional method to contain a human body or human remains, which includes the use for storage and transportation of the deceased at any crime scene or disaster scene. During disasters, most often than not, the first responders including the police will be equipped with cadaver body bags to do scene processing of human remains and collection of personal belongings at the disaster site. However, in an unanticipated large scale disasters involving hundreds and thousands of fatalities, cadaver body bags supplies may be scarce...
February 9, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29429111/health-risk-assessment-of-drinking-arsenic-containing-groundwater-in-hasilpur-pakistan-effect-of-sampling-area-depth-and-source
#7
Riaz Ahmad Tabassum, Muhammad Shahid, Camille Dumat, Nabeel Khan Niazi, Sana Khalid, Noor Samad Shah, Muhammad Imran, Samina Khalid
Currently, several news channels and research publications have highlighted the dilemma of arsenic (As)-contaminated groundwater in Pakistan. However, there is lack of data regarding groundwater As content of various areas in Pakistan. The present study evaluated As contamination and associated health risks in previously unexplored groundwater of Hasilpur-Pakistan. Total of 61 groundwater samples were collected from different areas (rural and urban), sources (electric pump, hand pump, and tubewell) and depths (35-430 ft or 11-131 m)...
February 10, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29427712/optimal-pcr-primers-for-rapid-and-accurate-detection-of-aspergillus-flavus-isolates
#8
Mohammed Baqur S Al-Shuhaib, Ali H Albakri, Sabah H Alwan, Noor B Almandil, Sayed AbdulAzeez, J Francis Borgio
Aspergillus flavus is among the most devastating opportunistic pathogens of several food crops including rice, due to its high production of carcinogenic aflatoxins. The presence of these organisms in economically important rice strip farming is a serious food safety concern. Several polymerase chain reaction (PCR) primers have been designed to detect this species; however, a comparative assessment of their accuracy has not been conducted. This study aims to identify the optimal diagnostic PCR primers for the identification of A...
February 7, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29425684/novel-ex-vivo-ovarian-cancer-tissue-explant-assay-for-prediction-of-chemosensitivity-and-response-to-novel-therapeutics
#9
Carmela Ricciardelli, Noor A Lokman, Ilhamjan Sabit, Kavyadharshini Gunasegaran, Wendy M Bonner, Carmen E Pyragius, Anne M Macpherson, Martin K Oehler
The majority of ovarian cancer patients present with advanced disease and despite aggressive treatment, prognosis remains poor. Response to first-line carboplatin-containing chemotherapy is usually good, however, recurrence rates and subsequent chemoresistance are very high and ultimately responsible for the fatal outcome of the disease. To improve treatment outcomes pre-clinical models that can predict individual patient response to 1st line chemotherapy and novel therapeutics are urgently required. In this study we employed an ex vivo ovarian cancer tissue explant assay to assess response to carboplatin and an inhibitor of the extracellular matrix molecule, hyaluronan (4-methylubelliferone, 4-MU), shown to inhibit cancer metastasis...
February 6, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29425471/antidiabetic-effect-of-rosella-stevia-tea-on-prediabetic-women-in-yogyakarta-indonesia
#10
Noor Rohmah Mayasari, Susetyowati, Mae Sri Hartati Wahyuningsih, Probosuseno
BACKGROUND: Rosella tea (Hibiscuss sabdariffa. Linn) with stevia sweetener (Stevia rebaudiana Bertoni) is a combined herbal drink that is expected to have antidiabetic effect by lowering glucose levels in people with diabetes and prediabetes. This research investigates the effect of rosella-stevia tea to decrease fasting blood glucose (FBG) and 2 hours postprandial blood glucose (2-hour postprandial BG) level in prediabetic women. METHOD: This is quasi-experimental research with control and treatment (rosella-stevia tea) group...
February 9, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29417395/islamic-considerations-on-the-application-of-patient-s-autonomy-in-end-of-life-decision
#11
Mohammad Mustaqim Malek, Noor Naemah Abdul Rahman, Mohd Shahnaz Hasan, Luqman Haji Abdullah
In end-of-life situation, the need for patient's preference comes into the picture with the intention of guiding physicians in the direction of patient care. Preference in medical directive is made by a person with full mental capacity outlining what actions should be taken for his health should he loses his competency. This is based on the reality of universal paradigm in medical practice that emphasises patient's autonomy. A specific directive is produced according to a patient's wish that might include some ethically and religiously controversial directives such as mercy killing, physician-assisted suicide, forgoing life-supporting treatments and do-not-resuscitate...
February 7, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29415255/validation-of-the-united-registries-for-clinical-assessment-and-research-ur-care-a-european-online-registry-for-clinical-care-and-research-in-inflammatory-bowel-disease
#12
Johan Burisch, Javier P Gisbert, Britta Siegmund, Dominik Bettenworth, Sandra Bohn Thomsen, Isabelle Cleynen, Anneline Cremer, Nik John Sheng Ding, Federica Furfaro, Michail Galanopoulos, Philip Christian Grunert, Jurij Hanzel, Tamara Knezevic Ivanovski, Eduards Krustins, Nurulamin Noor, Neil O'Morain, Iago Rodríguez-Lago, Michael Scharl, Julia Tua, Mathieu Uzzan, Nuha Ali Yassin, Filip Baert, Ebbe Langholz
Background: The "United Registries for Clinical Assessment and Research" (UR-CARE) database is an initiative of the European Crohn's and Colitis Organisation (ECCO) to facilitate daily patient care and research studies in inflammatory bowel disease (IBD). Herein, we sought to validate the database by using fictional case histories of patients with IBD that were to be entered by observers of varying experience in IBD. Methods: A total of 19 observers entered 5 patient case histories into the database...
February 3, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29413792/combined-effects-of-knee-brace-laterally-wedged-insoles-and-toe-in-gait-on-knee-adduction-moment-and-balance-in-moderate-medial-knee-osteoarthritis-patients
#13
Saad Jawaid Khan, Soobia Saad Khan, Juliana Usman, Abdul Halim Mokhtar, Noor Azuan Abu Osman
OBJECTIVE: To test the hypothesis that toe-in gait (TI) will further reduce first peak (Knee Adduction Moment) KAM and decrease balance when combined with a knee brace (KB) and laterally wedged insoles (LWI) in medial knee osteoarthritis (kOA) patients. PARTICIPANTS: Twenty patients with bilateral symptomatic medial kOA. INTERVENTIONS: 4-point leverage-based KB, full-length LWI with 5° inclination and toe-in gait (TI). MAIN OUTCOME MEASURES: First and second peak knee adduction moment (fKAM and sKAM respectively), balance and pain...
January 29, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29412105/tocotrienols-regulate-bone-loss-through-suppression-on-osteoclast-differentiation-and-activity-a-systematic-review
#14
Nur Fathiah Mohd Radzi, Noor Akmal Shareela Ismail, Ekram Alias
There are accumulating studies reporting vitamin E in general exhibits bone protective effects. This systematic review, however discusses the effects of a group of vitamin E isomers, tocotrienols in preventing bone loss through osteoclast differentiation and activity suppression. This review is aimed to discuss the literature reporting the effects of tocotrienols on osteoclasts, the cells specialized for resorbing bone. Literature search for relevant studies was conducted using SCOPUS and PUBMED MEDLINE. The inclusion criteria were original research articles published that reported the effect of any tocotrienol isomers or treatment with mixture containing tocotrienols on osteoclasts...
February 6, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29405924/multi-informant-assessments-of-adolescent-social-anxiety-adding-clarity-by-leveraging-reports-from-unfamiliar-peer-confederates
#15
Danielle E Deros, Sarah J Racz, Melanie F Lipton, Tara M Augenstein, Jeremy N Karp, Lauren M Keeley, Noor Qasmieh, Brigitte I Grewe, Amelia Aldao, Andres De Los Reyes
Adolescent social anxiety (SA) assessments often include adolescent and parent reports, and low reporting correspondence results in uncertainties in clinical decision-making. Adolescents display SA within non-home contexts such as peer interactions. Yet, current methods for collecting peer reports raise confidentiality concerns, though adolescent SA assessments nonetheless would benefit from context-specific reports relevant to adolescent SA (i.e., interactions with unfamiliar peers). In a sample of 89 adolescents (30 Evaluation-Seeking; 59 Community Control), we collected SA reports from adolescents and their parents, and SA reports from unfamiliar peer confederates who interacted with adolescents during 20-minute mock social interactions...
January 2018: Behavior Therapy
https://www.readbyqxmd.com/read/29402428/period-prevalence-and-factors-associated-with-road-traffic-crashes-among-young-adults-in-kuwait
#16
Eisa Aldhafeeri, Farah Alshammari, Hana Jafar, Haya Malhas, Marina Botras, Noor Alnasrallah, Saeed Akhtar
OBJECTIVES: This cross-sectional study assessed one-year period prevalence of road traffic crashes (RTCs) and examined the factors associated with RTCs among young adults in Kuwait. DESIGN AND SETTINGS: During December 2016, 1500 students enrolled in 15 colleges of Kuwait University were invited to participate in the study. Students 18 years old or older and who drive by themselves were eligible. Data were collected using a structured self-administered questionnaire...
February 2, 2018: Injury
https://www.readbyqxmd.com/read/29396252/glycated-albumin-and-the-risk-of-chronic-kidney-disease-in-subjects-with-type-2-diabetes-a-study-in-north-indian-population
#17
Alok Raghav, Jamal Ahmad, Saba Noor, Khursheed Alam, Brijesh Kumar Mishra
AIM: Glycated albumin (GA) suggested being alternative glycemic marker than haemoglobin A1C (HbA1c) in patients with chronic kidney diseases (CKD). We investigated the association between GA and the progression of diabetic nephropathy (DN) in T2DM subjects. METHODS: We recruited T2DM subjects with different stages of CKD who had regularly measured serum creatinine and estimated glomerular filtration rates (eGFR) according to Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines, HbA1c consecutively every 3 months along with GA levels and other anthropometric and demographic measurements...
January 30, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29395751/early-stroke-post-heart-transplant-is-associated-with-decreased-survival-in-children
#18
Cheryl Cammock, Swati Choudhry, Chesney M Castleberry, Noor Al-Hammadi, Pirooz Eghtesady, Charles E Canter, Kathleen E Simpson
BACKGROUND: Major neurologic events (MNEs) after heart transplantation (HTx) and their effect on survival have not been well described in children. In this study we aimed to characterize early MNEs (stroke, isolated seizures not from stroke and posterior reversible leukoencephalopathy [PRES] within 1 year after primary pediatric HTx) and evaluate their impact on 1-year post-HTx survival. We hypothesized that early an MNE after HTx is associated with decreased 1-year patient survival. METHODS: We performed a pediatric, single-center, retrospective analysis of 345 consecutive patients aged 0 to 22 years who underwent primary HTx during the period from November 1, 1994 to October 31, 2015...
January 9, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29391625/bioefficacy-potential-of-different-genotypes-of-walnut-juglans-regia-l
#19
Uzma Noor Shah, Javid Iqbal Mir, Nazeer Ahmed, Sumira Jan, Khalid Majid Fazili
The purpose of investigation was to assess the phytochemical and nutraceutical of walnut in leaf extracts through diverse quantitative and qualitative phytochemical tests followed by array of assays. The screening of 50 elite walnut genotypes which exhibited wide range of discrepancy in terms of phytochemicals as well as their anti-oxidant potential was done. Walnut genotypes displayed maximum divergence in quercetin content (2.86-5.78 mg/100 g) as represented by cluster analysis. The phenolic rich genotypes exhibiting total phenols (37...
February 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29387690/pancreatic-ductal-adenocarcinoma-epidemiology-and-risk-assessment-could-we-prevent-possibility-for-an-early-diagnosis
#20
Noor L H Bekkali, Kofi W Oppong
No abstract text is available yet for this article.
December 2017: Endoscopic Ultrasound
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