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https://www.readbyqxmd.com/read/29223505/pakistan-genetic-mutation-database-pgmd-a-centralized-pakistani-mutome-data-source
#1
Iqbal Qasim, Bilal Ahmad, Muzammil Ahmad Khan, Niamatullah Khan, Noor Muhammad, Sulman Basit, Saadullah Khan
The development and advancement of next generation sequencing have not only sped up the process of identifying rare variants, but have also enabled scientists to explore all variants in a single individual. The Pakistani population has a high ratio of first degree consanguinity, which is why it is a rich source for various kinds of genetic disorders. Due to the heterogeneous composition of Pakistani population, the likelihood of genetic heterogeneity for each disorder is high. Therefore, the compilation and organization of such vast genetic data is necessary to facilitate access for analysis and interpretation to researchers and medical geneticists...
December 6, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29221961/prevalence-of-high-on-treatment-aspirin-and-clopidogrel-platelet-reactivity-in-patients-with-critical-limb-ischemia
#2
Leonardo C Clavijo, Noor Al-Asady, Ashwat Dhillon, Ray V Matthews, Jorge Caro, Han Tun, Vincent Rowe, David M Shavelle
OBJECTIVES: The goal of this study is to establish the prevalence of high on-treatment platelet reactivity to aspirin (HPRA) and clopidogrel (HPRC) in patients with critical limb ischemia (CLI). BACKGROUND: CLI is associated with an increased risk of death and cardiovascular events. Unlike other patient populations with atherosclerotic cardiovascular disease, previous studies failed to demonstrate a benefit of antiplatelet therapy in patients with CLI. METHODS: From June 2014 to November 2016, we performed platelet reactivity studies for P2Y12 and thromboxane A2 (TXA2) inhibition in 100 CLI patients receiving daily treatment with aspirin and clopidogrel...
October 28, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29221542/ability-to-pay-for-future-national-health-financing-scheme-among-malaysian-households
#3
Azimatun Noor Aizuddin, Syed Mohamed Aljunid
BACKGROUND: Malaysia is no exception to the challenging health care financing phenomenon of globalization. OBJECTIVES: The objective of the present study was to assess the ability to pay among Malaysian households as preparation for a future national health financing scheme. METHODS: This was a cross-sectional study involving representative samples of 774 households in Peninsular Malaysia. FINDINGS: A majority of households were found to have the ability to pay for their health care...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29220738/increasing-value-and-reducing-waste-by-optimizing-the-development-of-complex-interventions-enriching-the-development-phase-of-the-medical-research-council-mrc-framework
#4
Nienke Bleijenberg, Janneke M de Man-van Ginkel, Jaap C A Trappenburg, Roelof G A Ettema, Carolien G Sino, Noor Heim, Thóra B Hafsteindóttir, David A Richards, Marieke J Schuurmans
BACKGROUND: In recent years there has been much emphasis on 'research waste' caused by poor question selection, insufficient attention to previous research results, and avoidable weakness in research design, conduct and analysis. Little attention has been paid to the effect of inadequate development of interventions before proceeding to a full clinical trial. OBJECTIVE: We therefore propose to enrich the development phase of the MRC Framework by adding crucial elements to improve the likelihood of success and enhance the fit with clinical practice METHODS: Based on existing intervention development guidance and synthesis, a comprehensive iterative intervention development approach is proposed...
December 5, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29214733/timing-and-sequence-of-emergence-of-permanent-teeth-in-syrian-schoolchildren
#5
Mayssoon Dashash, Noor Al-Jazar
AIM: The aim of the present study was to investigate the timing and sequence of the eruption of permanent teeth in Syrian schoolchildren. METHODS: A total of 1211 children aged 5-13 years were included. Every permanent tooth was scored according to its clinical stage of eruption. The significance of difference was tested using t test. RESULTS: The mean number of erupted teeth in children aged 5-6 years was 2.41 ± 2.68, and reached to 24...
December 6, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/29209668/salivary-parameters-among-arabian-snuff-shammah-users
#6
Mohammed S Al-Ak'hali, Esam S Halboub, Osama H Mujam, Noor M Alahmar, Salehah A Jerah, Fahad A Mutawwam
To evaluate the salivary flow rate (SFR),  pH, and buffer capacity (BC) among healthy shammah users (SU) in comparison with healthy non-shammah users (NSU). Methods: This case-control study was conducted at the College of Dentistry, Jazan University, Jazan, Kingdom of Saudi Arabia between March 2016 and May 2017. A sample of 27 SU and 30 NSU were recruited. Unstimulated saliva was collected and SFR, pH, and BC were determined. Dental health was assessed using the decay-missing-filled teeth (DMFT) index.  Results: Shammah users were slightly older than NSU (28...
December 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/29209382/listening-to-sentences-in-noise-revealing-binaural-hearing-challenges-in-patients-with-schizophrenia
#7
Noor Alaudin Abdul Wahab, Mohd Normani Zakaria, Abdul Hamid Abdul Rahman, Dinsuhaimi Sidek, Suzaily Wahab
Objective: The present, case-control, study investigates binaural hearing performance in schizophrenia patients towards sentences presented in quiet and noise. Methods: Participants were twenty-one healthy controls and sixteen schizophrenia patients with normal peripheral auditory functions. The binaural hearing was examined in four listening conditions by using the Malay version of hearing in noise test. The syntactically and semantically correct sentences were presented via headphones to the randomly selected subjects...
November 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29208865/assessment-of-postnatal-depression-by-edinburgh-postnatal-depression-scale-in-a-tertiary-care-hospital-of-bangladesh
#8
T Parveen, S Akhter, H H Parveen, F Noor, R K Kazal
The objective of the study was to estimate the prevalence of post partum depression and its associated risk factors among the mothers in their immediate post natal period. This cross sectional study was carried out in the Department of Obstetrics & Gynaecology, Bangabandhu Sheikh Mujib Medical University (BSMMU) and a tertiary care centre in Dhaka, Bangladesh from July 2015 to December 2015. Total 145 post natal mothers were screened for postnatal depression from day 5-7 following caesarean section by the validated Bangla version of Edinburgh Postnatal Depression Scale...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29208854/study-on-clinical-presentation-and-outcome-of-septic-abortion-and-its-relationship-with-person-inducing-abortion
#9
S Nahar, S Akhter, F Ahamed, K Akhtar, F Noor
Abortion is a global problem. Maternal mortality and morbidity is still high due to uncontrolled abortion mainly induced abortion which may turn to septic abortion. A total of 50 cases of septic abortion cases admitted in Dhaka Medical College Hospital were included in this study. This cross sectional study was designed to find out the clinical presentation and outcome of septic abortion from January 2010 to January 2011. Out of 50 cases of septic abortion admitted where 44(88%) were induced abortion. Majority of the cases were parous (2-3 parity 32%; 4-6 parity 38%; and 6+ parity 4%) and housewives 42(84%), living with their husbands 49(98%), hailing from urban, semi urban and urban slums...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29207777/an-aggressive-primary-retroperitoneal-diffuse-large-b-cell-lymphoma-mimicking-a-pancreatic-neoplasm-presenting-as-duodenal-stenosis
#10
Bharadhwaj Ravindhran, Clement Prakash, Sridar Govindharaj, Noor Mohammed Shawnaz Bahnou, B Pavithra
Diffuse Large B-Cell Lymphoma (DLBCL) is the most common histological subtype of Non-Hodgkin's Lymphoma (NHL). Primary retroperitoneal DLBCL is uncommon and has seldom been reported. Extrinsic compression of the duodenum due to lesions originating from the retroperitoneum is also rare. We present a case of a 39-year-old man who presented with inability to tolerate oral intake, abdominal pain, an upper abdominal mass and postprandial bilious vomiting caused by a large DLBCL arising from the retroperitoneum causing extrinsic compression of the duodenum...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29204257/feature-based-retinal-image-registration-using-d-saddle-feature
#11
Roziana Ramli, Mohd Yamani Idna Idris, Khairunnisa Hasikin, Noor Khairiah A Karim, Ainuddin Wahid Abdul Wahab, Ismail Ahmedy, Fatimah Ahmedy, Nahrizul Adib Kadri, Hamzah Arof
Retinal image registration is important to assist diagnosis and monitor retinal diseases, such as diabetic retinopathy and glaucoma. However, registering retinal images for various registration applications requires the detection and distribution of feature points on the low-quality region that consists of vessels of varying contrast and sizes. A recent feature detector known as Saddle detects feature points on vessels that are poorly distributed and densely positioned on strong contrast vessels. Therefore, we propose a multiresolution difference of Gaussian pyramid with Saddle detector (D-Saddle) to detect feature points on the low-quality region that consists of vessels with varying contrast and sizes...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29203255/increasing-prevalence-of-type-2-diabetes-mellitus-and-impact-of-ethnicity-in-north-sudan
#12
Mohamed A Eltom, Abubakr H Babiker Mohamed, Hind Elrayah-Eliadarous, Kamal Yassin, Sufian K Noor, Wadie M Elmadhoun, Mohamed H Ahmed
BACKGROUND: Diabetes mellitus constitutes a global health threat, with increasing burden of disease in low and middle-income countries witnessing ongoing epidemiological transition including Sudan. AIMS: To study the prevalence of type 2 diabetes mellitus (T2DM) and prediabetes and determine the relationship to gender, age, waist circumference, body mass index, residence and ethnicity among the adult population in north Sudan. METHODS: A cross-sectional, population-based study in Northern State and River Nile State using random multi-stage cluster sampling targeting 5,376 participants from 14 localities divided into 60 urban and 40 rural clusters...
December 1, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29202002/a-comparison-of-outcomes-between-a-lumen-apposing-metal-stent-with-electrocautery-enhanced-delivery-system-and-a-bi-flanged-metal-stent-for-drainage-of-walled-off-pancreatic-necrosis
#13
Noor L H Bekkali, Manu K Nayar, John S Leeds, Richard M Charnley, Matthew T Huggett, Kofi W Oppong
Background and study aims:  Bi-flanged metal stents (BFMS) have shown promise in the drainage of walled-off pancreatic necrosis (WON), but their placement requires multiple steps and the use of other devices. More recently, a novel device consisting of a combined lumen-apposing metal stent (LAMS) and electrocautery-enhanced delivery system has been introduced. The aim of this study was to compare the placement and outcomes of the two devices. Patients and methods:  This was a retrospective review of consecutive patients undergoing endoscopic ultrasound-guided placement of BFMS or LAMS for drainage of symptomatic WON...
December 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29201796/hepatic-venous-pressure-gradient-measurement-in-bangladeshi-cirrhotic-patients-a-correlation-with-child-s-status-variceal-size-and-bleeding
#14
Mamun Al Mahtab, Sheikh M Noor E Alam, Mohammad A Rahim, Mohammad A Alam, Faiz A Khondaker, Ahmed L Moben, Masuda Mohsena, Sheikh Mohammad Fazle Akbar
Background: Hepatic venous pressure gradient (HVPG) reflects the portal pressure in patients with cirrhotic portal hypertension. The aim of the study was to assess the relation of HVPG to variceal size, Child-Pugh status, and variceal bleeding. Materials and methods: A total of 96 patients with cirrhosis of liver were enrolled prospectively and each patient's HVPG level was measured via the transfemoral route. Clinical and biochemical evaluation and upper gastrointestinal (GI) endoscopy were done in each subject...
July 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29200197/control-of-piezoelectricity-in-amino-acids-by-supramolecular-packing
#15
Sarah Guerin, Aimee Stapleton, Drahomir Chovan, Rabah Mouras, Matthew Gleeson, Cian McKeown, Mohamed Radzi Noor, Christophe Silien, Fernando M F Rhen, Andrei L Kholkin, Ning Liu, Tewfik Soulimane, Syed A M Tofail, Damien Thompson
Piezoelectricity, the linear relationship between stress and induced electrical charge, has attracted recent interest due to its manifestation in biological molecules such as synthetic polypeptides or amino acid crystals, including gamma (γ) glycine. It has also been demonstrated in bone, collagen, elastin and the synthetic bone mineral hydroxyapatite. Piezoelectric coefficients exhibited by these biological materials are generally low, typically in the range of 0.1-10 pm V-1, limiting technological applications...
December 4, 2017: Nature Materials
https://www.readbyqxmd.com/read/29199518/improvement-on-upper-limb-body-powered-prostheses-1921-2016-a-systematic-review
#16
Nur Afiqah Hashim, Nasrul Anuar Abd Razak, Noor Azuan Abu Osman, Hossein Gholizadeh
Body-powered prostheses are known for their advantages of cost, reliability, training period, maintenance, and proprioceptive feedback. This study primarily aims to analyze the work related to the improvement of upper limb body-powered prostheses prior to 2016. A systematic review conducted via the search of the Web of Science electronic database, Google Scholar, and Google Patents identified 155 papers from 1921 to 2016. Sackett's initial rules of evidence were used to determine the levels of evidence, and only papers categorized in the design and development category and patents were analyzed...
December 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29198835/cinnamomum-burmanini-blume-increases-bone-turnover-marker-and-induces-tibia-s-granule-formation-in-ovariectomized-rats
#17
Nia Kania, Wahyu Widowati, Firli Rahmah Primula Dewi, Antonius Christianto, Bambang Setiawan, Nicolaas Budhiparama, Zairin Noor
BACKGROUND: Bone fragility and an increase in susceptibility to fracture osteoporosis is characterized by a reduction in bone mass and the micro-architectural deterioration of bone tissue. There is no previous study regarding the effect of Cinnamomum burmanini Blume on osteoporosis. OBJECTIVE: This study was aimed to investigate the effect of C. burmanini Blume on bone turnover marker, mineral elements, and mesostructure of ovariectomized rats. MATERIALS AND METHODS: Thirty female Wistar rats were randomly divided into five groups, which included a control group (sham surgery), ovariectomy group (OVX), and ovariectomy groups in the presence of ethanolic extract of C...
November 30, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29196969/rapid-and-reliable-protein-structure-determination-via-chemical-shift-threading
#18
Noor E Hafsa, Mark V Berjanskii, David Arndt, David S Wishart
Protein structure determination using nuclear magnetic resonance (NMR) spectroscopy can be both time-consuming and labor intensive. Here we demonstrate how chemical shift threading can permit rapid, robust, and accurate protein structure determination using only chemical shift data. Threading is a relatively old bioinformatics technique that uses a combination of sequence information and predicted (or experimentally acquired) low-resolution structural data to generate high-resolution 3D protein structures. The key motivations behind using NMR chemical shifts for protein threading lie in the fact that they are easy to measure, they are available prior to 3D structure determination, and they contain vital structural information...
December 1, 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/29195688/the-global-fight-against-malaria-is-at-crossroads
#19
Pedro Alonso, Abdisalan M Noor
No abstract text is available yet for this article.
November 28, 2017: Lancet
https://www.readbyqxmd.com/read/29190300/malera-an-updated-research-agenda-for-malaria-elimination-and-eradication
#20
Regina N Rabinovich, Chris Drakeley, Abdoulaye A Djimde, B Fenton Hall, Simon I Hay, Janet Hemingway, David C Kaslow, Abdisalan Noor, Fredros Okumu, Richard Steketee, Marcel Tanner, Timothy N C Wells, Maxine A Whittaker, Elizabeth A Winzeler, Dyann F Wirth, Kate Whitfield, Pedro L Alonso
Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the "Global Technical Strategy" and 21 countries are aiming to eliminate malaria by 2020. The commitment to achieve these targets should be celebrated. However, the need for innovation to achieve these goals, sustain elimination, and free the world of malaria is greater than ever...
November 2017: PLoS Medicine
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