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Afiqah Alyaa Md Fuzi, Siti Zawiah Omar, Zahurin Mohamed, Noor Azmi Mat Adenan, Norfilza Mohd Mokhtar
OBJECTIVE: To validate the gene expression profile obtained from the previous microarray analysis and to further study the biological functions of these genes in endometrial cancer. From our previous study, we identified 621 differentially expressed genes in laser-captured microdissected endometrioid endometrial cancer as compared to normal endometrial cells. Among these genes, 146 were significantly up-regulated in endometrial cancer. MATERIALS AND METHODS: A total of 20 genes were selected from the list of up-regulated genes for the validation assay...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
Seyed Mohammad Taghdisi, Noor Mohammad Danesh, Mohammad Ramezani, Rezvan Yazdian-Robati, Khalil Abnous
Active targeting of nanostructures containing chemotherapeutic agents can improve cancer treatment. Here, a three-way junction pocket DNA nanostructure was developed for efficient doxorubicin (Dox) delivery into cancer cells. Three-way junction pocket DNA nanostructure is composed of three strands of AS1411 aptamer as both therapeutic aptamer and nucleolin targeting, the potential biomarker of prostate (PC-3 cells) and breast (4T1 cells) cancers. The properties of the Dox-loaded three-way junction pocket DNA nanostructure was characterized and verified to have several advantages, including high serum stability and pH-responsive property...
April 18, 2018: Molecular Pharmaceutics
Dominika M Pindus, Ricky Mullis, Lisa Lim, Ian Wellwood, A Viona Rundell, Noor Azah Abd Aziz, Jonathan Mant
[This corrects the article DOI: 10.1371/journal.pone.0192533.].
2018: PloS One
Wipawan Muanghorn, Nattaya Konsue, Hasan Sham, Zainon Othman, Faizal Mohamed, Noramaliza Mohd Noor, Norsyafiqah Othman, Nur Shamin Shyamimi Mohd Noor Akmal, Nurulhuda Ahmad Fauzi, Mary Margaret Packiamuthu Dewaprigam Solomen, Ahmad Faizal Abdull Razis
Effects of food irradiation on allergen and nutritional composition of giant freshwater prawn are not well documented. Thus, this study aimed to investigate the effects of gamma irradiation on tropomyosin allergen, proximate composition, and mineral elements in Macrobrachium rosenbergii . In this study, prawn was peeled, cut into small pieces, vacuum packaged and gamma irradiated at 0, 5, 7, 10 and 15 kGy with a dose rate of 0.5 kGy/h using cobalt-60 as the source, subsequently determined the level of tropomyosin, proximate composition and mineral elements respectively...
May 2018: Journal of Food Science and Technology
Roshan Noor Mohamed, Sakeenabi Basha, Yousef Al-Thomali
OBJECTIVES: To evaluate the quantitative effects of miniscrew supported appliances for maxillary molar distalization in Class II malocclusion. MATERIALS AND METHODS: The systematic search included MEDLINE, EMBASE, CINAHL, PsychINFO, Scopus, and key journals and review articles. The date of the last search was January 30, 2017. Methodological quality of the retrospective studies was graded by means of the Quality Assessment Tool for Quantitative Studies, developed for the Effective Public Health Practice Project (EPHPP) and prospective studies by means of Newcastle-Ottawa Scale...
April 17, 2018: Angle Orthodontist
Muhammad Bilal, Abdul Haseeb, Mohammad H Arshad, Altamash A Jaliawala, Iman Farooqui, Amna Minhas, Ahmedullah Hussaini, Arsalan A Khan, Sharjeel Ahmad, Zainab Saleem, Ozair Awan, Noor Us Sabahat, Araib Ayaz, Haania Rizwan
Background In developing countries like Pakistan, treatment is mediated by private and public healthcare setups with a limited budget for health facilities. Moreover, the inappropriate use of treadmill tests imposes a burden on healthcare resources and leads to unwarranted interventions. Our aim is to assess the prevalence and predictors of inappropriate referrals for the exercise tolerance test (ETT) to diagnose coronary artery disease (CAD) while taking public and private healthcare settings into consideration...
January 23, 2018: Curēus
Francesco Marangoni, Ruan Zhang, Vinidhra Mani, Martin Thelen, Noor J Ali Akbar, Ross D Warner, Tarmo Äijö, Valentina Zappulli, Gustavo J Martinez, Laurence A Turka, Thorsten R Mempel
Regulatory T cells (Treg) restrain immune responses against malignant tumors, but their global depletion in cancer patients will likely be limited by systemic autoimmune toxicity. Instead, approaches to "tune" their activities may allow for preferential targeting of tumor-reactive Treg. Although Ag recognition regulates Treg function, the roles of individual TCR-dependent signaling pathways in enabling Treg to promote tumor tolerance are not well characterized. In this study, we examined in mouse tumor models the role of calcineurin, a key mediator of TCR signaling, and the role of the costimulatory receptor CD28 in the differentiation of resting central Treg into effector Treg endowed with tumor tropism...
April 16, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Yousef Shanti, Ithar Beshtawi, Sa'ed H Zyoud, Ahlam Abu-Samra, Areen Abu-Qamar, Reem Barakat, Reham Shehada
BACKGROUND: Keratoconus (KC) is a multifactorial, degenerative ectatic condition of the cornea. It usually manifests during late adolescence or the early twenties. A painless disease, KC may end with severe visual loss. The prevalence of KC in middle-eastern countries is much higher than in other regions of the world. This may be due to genetic and environmental risk factors and consanguinity. The goal of this study is to explore the demographic profile of Palestinian keratoconic patients...
April 16, 2018: BMC Ophthalmology
Khalid Mahmood, Iftikhar Haider Naqvi, Aamer Mahmood, Syed Muhammad, Noor Muhammad
Introduction: The hepatocellular carcinoma (HCC), being the commonest primary cancer, holds the sixth slot in the list of common cancers worldwide. Thrombotic complications in the form of portal vein tumour thrombosis (PVTT) and bland portal vein thrombosis with HCC are common with a bad prognosis. Aim: The study aims to determine the demographic, clinical, and biochemical parameters of HCC patients. The study also compares the clinical and biochemical parameters among patients having HCC with and without thrombotic complication...
2018: Przegla̜d Gastroenterologiczny
Firas Fahad Al-Zahrani, Hussain Al-Shahrani, Ashwaq Al-Mohawes, Abdullah Al-Hwiesh, Abdusalam Noor, Ibrahiem Saeed Abdulrahmn
Peritoneal dialysis (PD)-associated peritonitis is an important contributor to morbidity and mortality; Gram-positive bacteria constitute the most frequent associated pathogens (45%-60%) followed by Gram-negative bacteria (25%-40%) and fungal infection (3%-6%). Salmonella peritonitis is an extremely rare cause of peritonitis (0.15%). Peritonitis attributed to Salmonella has been reported only in four cases. Herewith, we report a 68-year-old Sudanese female who presented to our PD unit with abdominal pain and diarrhea and was diagnosed to have Salmonella peritonitis...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
Khalil Abnous, Noor Mohammad Danesh, Mohammad Ramezani, Seyed Mohammad Taghdisi, Ahmad Sarreshtehdar Emrani
Herein, a novel colorimetric aptasensor was introduced for detection of cocaine based on the formation of three-way junction pockets on the surfaces of gold nanoparticles (AuNPs) and the catalytic activity of the surfaces of AuNPs. Simplicity and detection of cocaine in a short time (only 35 min) are some of the unique features of the proposed sensing strategy. In the presence of cocaine, triple-fragment aptamer (TFA) forms on the surfaces of AuNPs, leading to a significant decrease of the catalytic activity of AuNPs and the color of samples remains yellow...
August 22, 2018: Analytica Chimica Acta
Nik Noor Kaussar Nik Mohd Hatta, Muhammad Lokman, Mohd Said N, Azlina Daud, Muhammad Ibrahim, Mohd Ariff Sharifudin, Samsul Deraman
OBJECTIVE: The study aims to identify the risk of obtaining a fracture among post-menopausal women with osteopenia and osteoporosis. METHOD: This work was a cross-sectional study involving a purposive sample of 87 post-menopausal women who attended the orthopedic and menopause clinics of Hospital Tengku Ampuan Afzan, Kuantan. The data were entered into the WHO fracture risk assessment tool (FRAX® ) to predict major fracture and risk for hip fracture in 10 years' time...
February 2018: Enfermería Clínica
Sanisah Saidi, Siti Nur Iliani Jaafar, Azlina Daud, Ramli Musa, Nik Noor Fatnoon Nik Ahmad
OBJECTIVE: The aim of this study was to investigate the correlation between levels of depression symptoms and age, thyroid-stimulating hormone levels, and stressful life events of the participants. METHOD: Patients above 18 years old, with any thyroid disorders, and without psychiatric disorders were included in this study. All participants completed the Depression Anxiety Stress Scale 21 (DASS-21). The depression symptom score was calculated and interpreted as follows: less than 9: no depression; between 10 and 13: mild depression; between 14 and 20: moderate depression; between 21 and 27: severe depression, and more than 28: extremely severe depression...
February 2018: Enfermería Clínica
Hani Nabilia Muhd Sahimi, John Keen Chubo, Marina Mohd Top Mohd Tah, Noor Bahiah Saripuddin, Siti Sarah Ab Rahim
Tarsius bancanus borneanus was first reported by Elliot in 1990 which an endemic species that can be found on the Island of Borneo consisting of Sabah and Sarawak of Malaysia, Brunei Darussalam and Kalimantan, Indonesia. This sub-species has been listed as a totally protected animal under the Sarawak Wild Life Protection Ordinance (1998) and vulnerable by the International Union for Conservation of Nature (IUCN). The present study was conducted at Universiti Putra Malaysia Bintulu Campus (UPMKB), Sarawak from October 2014 till March 2015...
March 2018: Tropical Life Sciences Research
Gunzo Kawamura, Teodora Bagarinao, Annita Seok Kian Yong, Siti Narasidah Noor, Leong-Seng Lim
The effect of low pH on the tactile sense of Macrobrachium rosenbergii postlarvae was determined in the laboratory by means of two behavioural assays: shelter (netting) occupancy and jumping response to touch stimuli (taps) by a glass micropipette. The postlarvae were acclimated to pH 4, pH 5, pH 6 and pH 7.5 (control) in 45 L aquaria 5-7 d before the experiments. Shelter occupancy decreased with pH and was significantly lower at pH 4 and pH 5 than at pH 6 and in the control. The jumping response instantly followed a tap 93-98% of the time in the control, pH 6 and pH 5 treatments...
March 2018: Tropical Life Sciences Research
Kim-Kee Tan, Noor Syahida Azizan, Che Norainon Yaacob, Nurul Asma Anati Che Mat Seri, Nur Izyan Samsudin, Boon-Teong Teoh, Sing-Sin Sam, Sazaly AbuBakar
BACKGROUND: A method for rapid detection of dengue virus using the reverse-transcription recombinase polymerase amplification (RT-RPA) was recently developed, evaluated and made ready for deployment. However, reliance solely on the evaluation performed by experienced researchers in a well-structured and well-equipped reference laboratory may overlook the potential intrinsic problems that may arise during deployment of the assay into new application sites, especially for users unfamiliar with the test...
April 11, 2018: BMC Infectious Diseases
B Kadum, C Inngul, R Ihrman, G O Sjödén, A S Sayed-Noor
Aims The aims of this study were to investigate any possible relationship between a preoperative sensitivity to pain and the degree of pain at rest and on exertion with postoperative function in patients who underwent stemless total shoulder arthroplasty (TSA). Patients and Methods In this prospective study, we included 63 patients who underwent stemless TSA and were available for evaluation one year postoperatively. There were 31 women and 32 men; their mean age was 71 years (53 to 89). The pain threshold, which was measured using a Pain Matcher (PM) unit, the degree of pain (visual analogue scale at rest and on exertion, and function using the short version of the Disabilities of the Arm, Shoulder and Hand questionnaire (QuickDASH), were recorded preoperatively, as well as three and 12 months postoperatively...
April 1, 2018: Bone & Joint Journal
Noraini Mohamad, Salziyan Badrin, Wan Noor Hasbee Wan Abdullah
Fixed cutaneous sporotrichosis is a differential diagnosis that can be considered in diabetic patients who present with a poorly healing ulcer. Although its prevalence is low, it can occur in patients with immunocompromised status. Here we report a case of a 70-year-old man with diabetes mellitus who presented with a 1-month history of an unhealed ulcer over the tip of his left middle finger. He experienced a cat bite over his left middle finger 1 month prior to the appearance of the lesion. A skin biopsy revealed the presence of Sporothrix schenckii ...
March 2018: Korean Journal of Family Medicine
Khu Say Li, M Abbas Ali, Ida Idayu Muhammad, Noor Hidayu Othman, Ahmadilfitri Md Noor
The impact of microwave roasting on the thermooxidative degradation of perah seed oil (PSO) was evaluated during heating at a frying temperature (170°C). The roasting resulted significantly lower increment of the values of oxidative indices such as free acidity, peroxide value, p-anisidine, total oxidation (TOTOX), specific extinctions and thiobarbituric acid in oils during heating. The colour L* (lightness) value dropped gradually as the heating time increased up to 12 h, whereas a*(redness) and b* (yellowness) tended to increase...
April 9, 2018: Journal of Oleo Science
Zheng-Yii Lee, Noor Airini Ibrahim, Barakatun-Nisak Mohd-Yusof
OBJECTIVES: The use of enteral nutrition (EN) in the intensive care unit (ICU) is subjected to frequent feeding interruption (FI). The prevalence and duration of causes for EN FI was investigated. METHODS: Reasons for EN FI identified from extensive literature review were prospectively collected in adult mechanically ventilated critically ill patients. Results were reported by descriptive statistics. Baseline and nutritional characteristics between patients who died and those alive at day 60 were compared...
January 31, 2018: Nutrition
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