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Mike English

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https://www.readbyqxmd.com/read/29229656/informing-future-research-for-carriage-of-multiresistant-gram-negative-bacteria-problems-with-recruiting-to-an-english-stool-sample-community-prevalence-study
#1
Donna M Lecky, Deborah Nakiboneka-Ssenabulya, Tom Nichols, Peter Hawkey, Kim Turner, Keun-Taik Chung, Mike Thomas, Helen Lucy Thomas, Li Xu McCrae, Sahida Shabir, Susan Manzoor, Adela Alvarez-Buylla, Steve Smith, Cliodna McNulty
OBJECTIVES: This study aims to highlight problems with recruiting to an English stool sample community prevalence study. It was part of a larger cross-sectional research to determine the risk factors for the presence of extended-spectrum beta-lactamase and carbapenemase-producing coliforms in stool samples of the asymptomatic general English population. SETTING: Four National Health Service primary care trusts (PCTs) of England representing a different section of the population of England: Newham PCT; Heart of Birmingham Teaching PCT; Shropshire County PCT; and Southampton City PCT...
December 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/29212522/a-systematic-review-of-neonatal-treatment-intensity-scores-and-their-potential-application-in-low-resource-setting-hospitals-for-predicting-mortality-morbidity-and-estimating-resource-use
#2
Jalemba Aluvaala, Gary S Collins, Michuki Maina, James A Berkley, Mike English
BACKGROUND: Treatment intensity scores can predict mortality and estimate resource use. They may therefore be of interest for essential neonatal care in low resource settings where neonatal mortality remains high. We sought to systematically review neonatal treatment intensity scores to (1) assess the level of evidence on predictive performance in predicting clinical outcomes and estimating resource utilisation and (2) assess the applicability of the identified models to decision making for neonatal care in low resource settings...
December 7, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29207988/correction-to-an-exploration-of-mortality-risk-factors-in-non-severe-pneumonia-in-children-using-clinical-data-from-kenya
#3
Timothy Tuti, Ambrose Agweyu, Paul Mwaniki, Niels Peek, Mike English
The original article contains an omission in the Acknowledgements sub-section of the Declarations.
December 5, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29177099/estimating-the-need-for-inpatient-neonatal-services-an-iterative-approach-employing-evidence-and-expert-consensus-to-guide-local-policy-in-kenya
#4
REVIEW
Georgina A V Murphy, Donald Waters, Paul O Ouma, David Gathara, Sasha Shepperd, Robert W Snow, Mike English
Universal access to quality newborn health services will be essential to meeting specific Sustainable Development Goals to reduce neonatal and overall child mortality. Data for decision making are crucial for planning services and monitoring progress in these endeavours. However, gaps in local population-level and facility-based data hinder estimation of health service requirements for effective planning in many low-income and middle-income settings. We worked with local policy makers and experts in Nairobi City County, an area with a population of four million and the highest neonatal mortality rate amongst counties in Kenya, to address this gap, and developed a systematic approach to use available data to support policy and planning...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29175225/-pastoral-practices-for-quality-improvement-in-a-kenyan-clinical-network
#5
Gerry McGivern, Jacinta Nzinga, Mike English
We explain social and organisational processes influencing health professionals in a Kenyan clinical network to implement a form of quality improvement (QI) into clinical practice, using the concept of 'pastoral practices'. Our qualitative empirical case study, conducted in 2015-16, shows the way practices constructing and linking local evidence-based guidelines and data collection processes provided a foundation for QI. Participation in these constructive practices gave network leaders pastoral status to then inscribe use of evidence and data into routine care, through championing, demonstrating, supporting and mentoring, with the support of a constellation of local champions...
November 20, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29146662/comparative-effectiveness-of-injectable-penicillin-versus-a-combination-of-penicillin-and-gentamicin-in-children-with-pneumonia-characterised-by-indrawing-in-kenya-a-retrospective-observational-study
#6
Lucas Malla, Rafael Perera-Salazar, Emily McFadden, Mike English
OBJECTIVES: Kenyan guidelines for antibiotic treatment of pneumonia recommended treatment of pneumonia characterised by indrawing with injectable penicillin alone in inpatient settings until early 2016. At this point, they were revised becoming consistent with WHO guidance after results of a Kenyan trial provided further evidence of equivalence of oral amoxicillin and injectable penicillin. This change also made possible use of oral amoxicillin for outpatient treatment in this patient group...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29129186/an-exploration-of-mortality-risk-factors-in-non-severe-pneumonia-in-children-using-clinical-data-from-kenya
#7
Timothy Tuti, Ambrose Agweyu, Paul Mwaniki, Niels Peek, Mike English
BACKGROUND: Childhood pneumonia is the leading infectious cause of mortality in children younger than 5 years old. Recent updates to World Health Organization pneumonia guidelines recommend outpatient care for a population of children previously classified as high risk. This revision has been challenged by policymakers in Africa, where mortality related to pneumonia is higher than in other regions and often complicated by comorbidities. This study aimed to identify factors that best discriminate inpatient mortality risk in non-severe pneumonia and explore whether these factors offer any added benefit over the current criteria used to identify children with pneumonia requiring inpatient care...
November 13, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29104769/does-audit-and-feedback-improve-the-adoption-of-recommended-practices-evidence-from-a-longitudinal-observational-study-of-an-emerging-clinical-network-in-kenya
#8
Susan Gachau, Philip Ayieko, David Gathara, Paul Mwaniki, Morris Ogero, Samuel Akech, Michuki Maina, Ambrose Agweyu, Jacqiue Oliwa, Thomas Julius, Lucas Malla, James Wafula, George Mbevi, Grace Irimu, Mike English
Background: Audit and feedback (A&F) is widely used in healthcare but there are few examples of how to deploy it at scale in low-income countries. Establishing the Clinical Information Network (CIN) in Kenya provided an opportunity to examine the effect of A&F delivered as part of a wider set of activities to promote paediatric guideline adherence. Methods: We analysed data collected from medical records on discharge for children aged 2-59 months from 14 Kenyan hospitals in the CIN...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29097339/comparable-outcomes-among-trial-and-non-trial-participants-in-a-clinical-trial-of-antibiotics-for-childhood-pneumonia-a-retrospective-cohort-study
#9
Ambrose Agweyu, Jacquie Oliwa, David Gathara, Naomi Muinga, Elizabeth Allen, Richard J Lilford, Mike English
OBJECTIVE: We compared characteristics and outcomes of children enrolled in a randomized controlled trial (RCT) comparing oral amoxicillin and benzyl penicillin for the treatment of chest indrawing pneumonia versus children who received routine care to determine the external validity of the trial results. STUDY DESIGN AND SETTING: We undertook a retrospective cohort study of children aged 2 - 59 months admitted in six Kenyan hospitals. Data for non-trial participants were extracted from inpatient records upon conclusion of the RCT...
October 30, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29080284/pulse-oximetry-values-of-neonates-admitted-for-care-and-receiving-routine-oxygen-therapy-at-a-resource-limited-hospital-in-kenya
#10
Melissa C Morgan, Beth Maina, Mary Waiyego, Catherine Mutinda, Jalemba Aluvaala, Michuki Maina, Mike English
AIM: There are 2.7 million neonatal deaths annually, 75% of which occur in sub-Saharan Africa and South Asia. Effective treatment of hypoxaemia through tailored oxygen therapy could reduce neonatal mortality and prevent oxygen toxicity. METHODS: We undertook a two-part prospective study of neonates admitted to a neonatal unit in Nairobi, Kenya, between January and December 2015. We determined the prevalence of hypoxaemia and explored associations of clinical risk factors and signs of respiratory distress with hypoxaemia and mortality...
October 27, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29062911/using-data-from-a-multi-hospital-clinical-network-to-explore-prevalence-of-pediatric-rickets-in-kenya
#11
Stella W Karuri, Maureen K Murithi, Grace Irimu, Mike English
Background: Nutritional rickets is a public health concern in developing countries despite tropical climates and a re-emerging issue in developed countries. In this study, we reviewed pediatric admission data from the Clinical Information Network (CIN) to help determine hospital and region based prevalence of rickets in three regions of Kenya (Central Kenya, Western Kenya and Nairobi County). We also examine the association of rickets with other diagnosis, such as malnutrition and pneumonia, and study the effect of rickets on regional hospital stays...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/29021979/everybody-brush-consumer-satisfaction-with-a-tooth-decay-prevention-program
#12
Joana Cunha-Cruz, Colleen E Huebner, Sharity Ludwig, Jeanne Dysert, Melissa Mitchell, Gary Allen, R Mike Shirtcliff, JoAnna M Scott, Peter Milgrom
INTRODUCTION: Twice-daily caregiver-supervised toothbrushing with fluoridated toothpaste is an effective and widely recommended strategy to prevent tooth decay in children. Qualitative research suggests that low-income caregivers know the recommendation but would benefit from toothbrushing supplies and advice about how to introduce this health behavior especially as the child becomes older and asserts autonomy to do it "myself." Our objective is to assess consumer satisfaction with the evidence-based theory-informed campaign and usefulness of materials that were home delivered...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28982824/are-survival-and-mortality-rates-associated-with-recruitment-to-clinical-trials-in-teenage-and-young-adult-patients-with-acute-lymphoblastic-leukaemia-a-retrospective-observational-analysis-in-england
#13
Rachael Hough, Sabrina Sandhu, Maria Khan, Anthony Moran, Richard Feltbower, Charles Stiller, Mike C G Stevens, Clare Rowntree, Ajay Vora, Martin G McCabe
OBJECTIVE: Participation rates in clinical trials are low in teenagers and young adults (TYA) with cancer. Whilst the importance of clinical trials in informing best practice is well established, data regarding individual patient benefit are scarce. We have investigated the association between overall survival and trial recruitment in TYA patients with acute lymphoblastic leukaemia (ALL). DESIGN: Retrospective. SETTING: National (England) TYA patients treated for ALL...
October 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28980833/handling-missing-data-in-propensity-score-estimation-in-comparative-effectiveness-evaluations-a-systematic-review
#14
Lucas Malla, Rafael Perera-Salazar, Emily McFadden, Morris Ogero, Kasia Stepniewska, Mike English
AIM: Even though systematic reviews have examined how aspects of propensity score methods are used, none has reviewed how the challenge of missing data is addressed with these methods. This review therefore describes how missing data are addressed with propensity score methods in observational comparative effectiveness studies. METHODS: Published articles on observational comparative effectiveness studies were extracted from MEDLINE and EMBASE databases. RESULTS: Our search yielded 167 eligible articles...
October 5, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28961937/trade-offs-between-seed-and-leaf-size-seed-phytomer-leaf-theory-functional-glue-linking-regenerative-with-life-history-strategies-%C3%A2-and-taxonomy-with-ecology
#15
John G Hodgson, Bianca A Santini, Gabriel Montserrat Marti, Ferran Royo Pla, Glynis Jones, Amy Bogaard, Mike Charles, Xavier Font, Mohammed Ater, Abdelkader Taleb, Peter Poschlod, Younes Hmimsa, Carol Palmer, Peter J Wilson, Stuart R Band, Amy Styring, Charlotte Diffey, Laura Green, Erika Nitsch, Elizabeth Stroud, Angel Romo-Díez, Lluis de Torres Espuny, Gemma Warham
Background and Aims: While the 'worldwide leaf economics spectrum' (Wright IJ, Reich PB, Westoby M, et al. 2004. The worldwide leaf economics spectrum. Nature : 821-827) defines mineral nutrient relationships in plants, no unifying functional consensus links size attributes. Here, the focus is upon leaf size, a much-studied plant trait that scales positively with habitat quality and components of plant size. The objective is to show that this wide range of relationships is explicable in terms of a seed-phytomer-leaf (SPL) theoretical model defining leaf size in terms of trade-offs involving the size, growth rate and number of the building blocks (phytomers) of which the young shoot is constructed...
November 10, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28942732/is-graves-disease-a-primary-immunodeficiency-new-immunological-perspectives-on-an-endocrine-disease
#16
REVIEW
Tristan Struja, Alexander Kutz, Stefan Fischli, Christian Meier, Beat Mueller, Mike Recher, Philipp Schuetz
BACKGROUND: Uncertainty about factors influencing the susceptibility and triggers for Graves' disease persists, along with a wide variation in the response to anti-thyroid drugs, currently at approximately 50% of non-responders. The aim of this narrative review is to summarize immunological concepts, with a combined endocrine and immunological perspective, to highlight potential new areas of research. MAIN TEXT: Relevant studies were identified through a systematic literature search using the PubMed and EMBASE databases in March 2016...
September 25, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28928185/comparative-effectiveness-of-injectable-penicillin-versus-a-combination-of-penicillin-and-gentamicin-in-children-with-pneumonia-characterised-by-indrawing-in-kenya-protocol-for-an-observational-study
#17
Lucas Malla, Rafael Perera-Salazar, Emily McFadden, Mike English
INTRODUCTION: WHO treatment guidelines are widely recommended for guiding treatment for millions of children with pneumonia every year across multiple low-income and middle-income countries. Guidelines are based on synthesis of available evidence that provides moderate certainty in evidence of effects for forms of pneumonia that can result in hospitalisation. However, trials have included fewer children from Africa than other settings, and it is suggested that African children with pneumonia have higher mortality...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28890264/breastfeeding-is-associated-with-higher-retention-in-wic-after-age-1
#18
Shannon E Whaley, Mike Whaley, Lauren E Au, Klara Gurzo, Lorrene D Ritchie
OBJECTIVE: Examine factors associated with retention on the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) after 1 year of age. SETTING: A large California WIC program. PARTICIPANTS: WIC participants 14 months old (9,632) between July and September, 2016. MAIN OUTCOME MEASURE: Recertification in WIC by 14 months of age. ANALYSIS: Multivariate logistic regression was performed and odds ratios (ORs) and 95% confidence intervals (CIs) were computed to examine factors associated with child retention in WIC at age 14 months...
November 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28877729/effect-of-enhanced-feedback-to-hospitals-that-are-part-of-an-emerging-clinical-information-network-on-uptake-of-revised-childhood-pneumonia-treatment-policy-study-protocol-for-a-cluster-randomized-trial
#19
Philip Ayieko, Grace Irimu, Mike English
BACKGROUND: The national pneumonia treatment guidelines in Kenya changed in February 2016 but such guideline changes are often characterized by prolonged delays in affecting practice. We designed an enhanced feedback intervention, delivered within an ongoing clinical network that provides a general form of feedback, aimed at improving and sustaining uptake of the revised pneumonia treatment policy. The objective was to determine whether an enhanced feedback intervention will improve correctness of classification and treatment of childhood pneumonia, compared to an existing approach to feedback, after nationwide treatment policy change and within an existing hospital network...
September 7, 2017: Trials
https://www.readbyqxmd.com/read/28870096/major-health-service-transformation-and-the-public-voice-conflict-challenge-or-complicity
#20
Graham P Martin, Pam Carter, Mike Dent
Objectives Calls for major reconfigurations of health services have been accompanied by recommendations that wide ranging stakeholders be involved. In particular, patients and the wider public are seen as critical contributors as both funders and beneficiaries of public health care. But public involvement is fraught with challenges, and little research has focused on involvement in the health service transformation initiatives. This paper examines the design and function of public involvement in reconfiguration of health services within the English NHS...
January 1, 2017: Journal of Health Services Research & Policy
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