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John Edmunds

Frederick J Kohlhapp, Erica J Huelsmann, Andrew T Lacek, Jason M Schenkel, Jevgenijs Lusciks, Joseph R Broucek, Josef W Goldufsky, Tasha Hughes, Janet P Zayas, Hubert Dolubizno, Ryan T Sowell, Regina Kühner, Sarah Burd, John C Kubasiak, Arman Nabatiyan, Sh'Rae Marshall, Praveen K Bommareddy, Shengguo Li, Jenna H Newman, Claude E Monken, Sasha H Shafikhani, Amanda L Marzo, Jose A Guevara-Patino, Ahmed Lasfar, Paul G Thomas, Edmund C Lattime, Howard L Kaufman, Andrew Zloza
In light of increased cancer prevalence and cancer-specific deaths in patients with infections, we investigated whether infections alter anti-tumor immune responses. We report that acute influenza infection of the lung promotes distal melanoma growth in the dermis and leads to accelerated cancer-specific host death. Furthermore, we show that during influenza infection, anti-melanoma CD8(+) T cells are shunted from the tumor to the infection site, where they express high levels of the inhibitory receptor programmed cell death protein 1 (PD-1)...
October 18, 2016: Cell Reports
Scott N Furlan, Benjamin Watkins, Victor Tkachev, Sarah Cooley, Angela Panoskaltsis-Mortari, Kayla Betz, Melanie Brown, Daniel J Hunt, John B Schell, Katie Zeleski, Alison Yu, Cindy Giver, Edmund Waller, Jeffrey S Miller, Bruce R Blazar, Leslie S Kean
One of the central challenges of transplantation is the development of alloreactivity despite the use of multi-agent immunoprophylaxis. Effective control of this immune-suppression-resistant T cell activation represents one of the key unmet needs in the fields of both solid organ and hematopoietic stem cell transplant (HCT). To address this unmet need, we have used a highly-translational non-human primate model to interrogate the transcriptional signature of T cells during Breakthrough Acute GVHD that occurs in the setting of clinically-relevant immune suppression and compared this to the Hyperacute GVHD, that develops in unprophylaxed or sub-optimally prophylaxed transplant recipients...
October 6, 2016: Blood
R Brent Stansfield, Lisa Diponio, Cliff Craig, John Zeller, Edmund Chadd, Joshua Miller, Seetha Monrad
BACKGROUND: Medical students have difficulty performing and interpreting musculoskeletal physical examinations and interpreting the findings. Research has focused on students' knowledge deficits, but there are few direct assessments of students' ability to perform a hypothesis-driven physical examination (HDPE). We developed a novel musculoskeletal Objective Structured Clinical Exam (OSCE) focusing on HDPE skills for disorders of the shoulder, back and knee, and used it to explore medical student diagnostic reasoning...
October 14, 2016: BMC Medical Education
Esther van Kleef, Sarah R Deeny, Mark Jit, Barry Cookson, Simon D Goldenberg, W John Edmunds, Julie V Robotham
BACKGROUND: Early clinical trials of a Clostridium difficile toxoid vaccine show efficacy in preventing C. difficile infection (CDI). The optimal patient group to target for vaccination programmes remains unexplored. This study performed a model-based evaluation of the effectiveness of different CDI vaccination strategies, within the context of existing infection prevention and control strategies such as antimicrobial stewardship. METHODS: An individual-based transmission model of CDI in a high-risk hospital setting was developed...
October 7, 2016: Vaccine
Anning Li, Yue Wu, Jenny Linnoila, Benjamin Pulli, Cuihua Wang, Matthias Zeller, Muhammad Ali, Grant K Lewandrowski, Jinghui Li, Benoit Tricot, Edmund Keliher, Gregory R Wojtkiewicz, Giulia Fulci, Xiaoyuan Feng, Bakhos A Tannous, Zhenwei Yao, John W Chen
Currently, there is no stable and flexible method to label and track cytotoxic T lymphocytes (CTLs) in vivo in CTL immunotherapy. We aimed to evaluate whether the sulfo-hydroxysuccinimide (NHS)-biotin-streptavidin (SA) platform could chemically modify the cell surface of CTLs for in vivo tracking. CD8+ T lymphocytes were labeled with sulfo-NHS-biotin under different conditions and then incubated with SA-Alexa647. Labeling efficiency was proportional to sulfo-NHS-biotin concentration. CD8+ T lymphocytes could be labeled with higher efficiency with sulfo-NHS-biotin in DPBS than in RPMI (P < 0...
October 8, 2016: Cancer Immunology, Immunotherapy: CII
Laith Yakob, Adam Kucharski, Stephane Hue, W John Edmunds
No abstract text is available yet for this article.
October 2016: Lancet Infectious Diseases
Ernest Cudjoe Opoku, Annette Olsen, Edmund Browne, Abraham Hodgson, John K Awoonor-Williams, Lawrence Yelifari, John Williams, Pascal Magnussen
BACKGROUND: The benefits of integrated control of malaria, schistosomiasis, and soil-transmitted helminth infections have not been fully explored in Ghanaian schoolchildren. OBJECTIVE: To assess the impact of co-administered artemether-lumefantrine plus albendazole, and artemether-lumefantrine plus albendazole plus praziquantel compared to albendazole plus praziquantel on anaemia, sustained attention, and recall in schoolchildren. DESIGN: This three-arm, open-label intervention study was carried out in Ghana among class three schoolchildren...
2016: Global Health Action
Girum Mekonnen, Salim S Hayek, Puja K Mehta, Qunna Li, Ernestine Mahar, Liping Mou, Tanya S Kenkre, John W Petersen, Babak Azarbal, Bruce Samuels, R David Anderson, Tara Sedlak, Melody Zaya, Megha Agarwal, Afsaneh Haftbaradaran, Margo Minissian, Eileen Handberg, Carl J Pepine, Christopher R Cogle, C Noel Bairey Merz, Edmund K Waller, Arshed A Quyyumi
BACKGROUND AND AIMS: Ischemia stimulates a reparative response resulting in mobilization of circulating progenitor cells (CPCs). We hypothesized that women with chronic myocardial ischemia from coronary microvascular disease (CMD) will mobilize CPCs. METHODS: In 123 women with ischemic symptoms and signs but no obstructive coronary artery disease (CAD) enrolled in the Women's Ischemia Syndrome Evaluation - Coronary Vascular Dysfunction Study (WISE-CVD), we measured coronary flow reserve (CFR) in response to intracoronary adenosine...
October 2016: Atherosclerosis
Tarylee Reddy, Geert Molenberghs, Edmund Njeru Njagi, Marc Aerts
In longitudinal studies of biomarkers, an outcome of interest is the time at which a biomarker reaches a particular threshold. The CD4 count is a widely used marker of human immunodeficiency virus progression. Because of the inherent variability of this marker, a single CD4 count below a relevant threshold should be interpreted with caution. Several studies have applied persistence criteria, designating the outcome as the time to the occurrence of two consecutive measurements less than the threshold. In this paper, we propose a method to estimate the time to attainment of two consecutive CD4 counts less than a meaningful threshold, which takes into account the patient-specific trajectory and measurement error...
September 1, 2016: Pharmaceutical Statistics
M John Broulidakis, Graeme Fairchild, Kate Sully, Thomas Blumensath, Angela Darekar, Edmund J S Sonuga-Barke
OBJECTIVE: Conduct disorder (CD) is characterized by impulsive, aggressive, and antisocial behaviors that might be related to deficits in empathy and moral reasoning. The brain's default mode network (DMN) has been implicated in self-referential cognitive processes of this kind. METHOD: This study examined connectivity between key nodes of the DMN in 29 adolescent boys with CD and 29 age- and sex-matched typically developing adolescent boys. The authors ensured that group differences in DMN connectivity were not explained by comorbidity with other disorders by systematically controlling for the effects of substance use disorders (SUDs), attention-deficit/hyperactivity disorder (ADHD) symptoms, psychopathic traits, and other common mental health problems...
September 2016: Journal of the American Academy of Child and Adolescent Psychiatry
George P Bailey, David M Wood, John R H Archer, Edmund Rab, Robert J Flanagan, Paul I Dargan
BACKGROUND: Intravenous acetylcysteine is the treatment of choice for paracetamol poisoning. A previous UK study in 2001 found that 39% of measured acetylcysteine infusion concentrations differed by >20% from anticipated concentrations. In 2012 the UK Commission on Human Medicines made recommendations for the management of paracetamol overdose, including provision of weight-based acetylcysteine dosing tables. The aim of this study was to assess variation in acetylcysteine concentrations in administered infusions following the introduction of this guidance...
August 24, 2016: British Journal of Clinical Pharmacology
Andrew Searles, Chris Doran, John Attia, Darryl Knight, John Wiggers, Simon Deeming, Joerg Mattes, Brad Webb, Steve Hannan, Rod Ling, Kim Edmunds, Penny Reeves, Michael Nilsson
BACKGROUND: Research translation, particularly in the biomedical area, is often discussed but there are few methods that are routinely used to measure it or its impact. Of the impact measurement methods that are used, most aim to provide accountability - to measure and explain what was generated as a consequence of funding research. This case study reports on the development of a novel, conceptual framework that goes beyond measurement. The Framework To Assess the Impact from Translational health research, or FAIT, is a platform designed to prospectively measure and encourage research translation and research impact...
2016: Health Research Policy and Systems
V M Abazov, B Abbott, B S Acharya, M Adams, T Adams, J P Agnew, G D Alexeev, G Alkhazov, A Alton, A Askew, S Atkins, K Augsten, V Aushev, Y Aushev, C Avila, F Badaud, L Bagby, B Baldin, D V Bandurin, S Banerjee, E Barberis, P Baringer, J F Bartlett, U Bassler, V Bazterra, A Bean, M Begalli, L Bellantoni, S B Beri, G Bernardi, R Bernhard, I Bertram, M Besançon, R Beuselinck, P C Bhat, S Bhatia, V Bhatnagar, G Blazey, S Blessing, K Bloom, A Boehnlein, D Boline, E E Boos, G Borissov, M Borysova, A Brandt, O Brandt, M Brochmann, R Brock, A Bross, D Brown, X B Bu, M Buehler, V Buescher, V Bunichev, S Burdin, C P Buszello, E Camacho-Pérez, B C K Casey, H Castilla-Valdez, S Caughron, S Chakrabarti, K M Chan, A Chandra, E Chapon, G Chen, S W Cho, S Choi, B Choudhary, S Cihangir, D Claes, J Clutter, M Cooke, W E Cooper, M Corcoran, F Couderc, M-C Cousinou, J Cuth, D Cutts, A Das, G Davies, S J de Jong, E De La Cruz-Burelo, F Déliot, R Demina, D Denisov, S P Denisov, S Desai, C Deterre, K DeVaughan, H T Diehl, M Diesburg, P F Ding, A Dominguez, A Drutskoy, A Dubey, L V Dudko, A Duperrin, S Dutt, M Eads, D Edmunds, J Ellison, V D Elvira, Y Enari, H Evans, A Evdokimov, V N Evdokimov, A Fauré, L Feng, T Ferbel, F Fiedler, F Filthaut, W Fisher, H E Fisk, M Fortner, H Fox, J Franc, S Fuess, P H Garbincius, A Garcia-Bellido, J A García-González, V Gavrilov, W Geng, C E Gerber, Y Gershtein, G Ginther, O Gogota, G Golovanov, P D Grannis, S Greder, H Greenlee, G Grenier, Ph Gris, J-F Grivaz, A Grohsjean, S Grünendahl, M W Grünewald, T Guillemin, G Gutierrez, P Gutierrez, J Haley, L Han, K Harder, A Harel, J M Hauptman, J Hays, T Head, T Hebbeker, D Hedin, H Hegab, A P Heinson, U Heintz, C Hensel, I Heredia-De La Cruz, K Herner, G Hesketh, M D Hildreth, R Hirosky, T Hoang, J D Hobbs, B Hoeneisen, J Hogan, M Hohlfeld, J L Holzbauer, I Howley, Z Hubacek, V Hynek, I Iashvili, Y Ilchenko, R Illingworth, A S Ito, S Jabeen, M Jaffré, A Jayasinghe, M S Jeong, R Jesik, P Jiang, K Johns, E Johnson, M Johnson, A Jonckheere, P Jonsson, J Joshi, A W Jung, A Juste, E Kajfasz, D Karmanov, I Katsanos, M Kaur, R Kehoe, S Kermiche, N Khalatyan, A Khanov, A Kharchilava, Y N Kharzheev, I Kiselevich, J M Kohli, A V Kozelov, J Kraus, A Kumar, A Kupco, T Kurča, V A Kuzmin, S Lammers, P Lebrun, H S Lee, S W Lee, W M Lee, X Lei, J Lellouch, D Li, H Li, L Li, Q Z Li, J K Lim, D Lincoln, J Linnemann, V V Lipaev, R Lipton, H Liu, Y Liu, A Lobodenko, M Lokajicek, R Lopes de Sa, R Luna-Garcia, A L Lyon, A K A Maciel, R Madar, R Magaña-Villalba, S Malik, V L Malyshev, J Mansour, J Martínez-Ortega, R McCarthy, C L McGivern, M M Meijer, A Melnitchouk, D Menezes, P G Mercadante, M Merkin, A Meyer, J Meyer, F Miconi, N K Mondal, M Mulhearn, E Nagy, M Narain, R Nayyar, H A Neal, J P Negret, P Neustroev, H T Nguyen, T Nunnemann, J Orduna, N Osman, A Pal, N Parashar, V Parihar, S K Park, R Partridge, N Parua, A Patwa, B Penning, M Perfilov, Y Peters, K Petridis, G Petrillo, P Pétroff, M-A Pleier, V M Podstavkov, A V Popov, M Prewitt, D Price, N Prokopenko, J Qian, A Quadt, B Quinn, P N Ratoff, I Razumov, I Ripp-Baudot, F Rizatdinova, M Rominsky, A Ross, C Royon, P Rubinov, R Ruchti, G Sajot, A Sánchez-Hernández, M P Sanders, A S Santos, G Savage, M Savitskyi, L Sawyer, T Scanlon, R D Schamberger, Y Scheglov, H Schellman, M Schott, C Schwanenberger, R Schwienhorst, J Sekaric, H Severini, E Shabalina, V Shary, S Shaw, A A Shchukin, V Simak, P Skubic, P Slattery, G R Snow, J Snow, S Snyder, S Söldner-Rembold, L Sonnenschein, K Soustruznik, J Stark, N Stefaniuk, D A Stoyanova, M Strauss, L Suter, P Svoisky, M Titov, V V Tokmenin, Y-T Tsai, D Tsybychev, B Tuchming, C Tully, L Uvarov, S Uvarov, S Uzunyan, R Van Kooten, W M van Leeuwen, N Varelas, E W Varnes, I A Vasilyev, A Y Verkheev, L S Vertogradov, M Verzocchi, M Vesterinen, D Vilanova, P Vokac, H D Wahl, M H L S Wang, J Warchol, G Watts, M Wayne, J Weichert, L Welty-Rieger, M R J Williams, G W Wilson, M Wobisch, D R Wood, T R Wyatt, Y Xie, R Yamada, S Yang, T Yasuda, Y A Yatsunenko, W Ye, Z Ye, H Yin, K Yip, S W Youn, J M Yu, J Zennamo, T G Zhao, B Zhou, J Zhu, M Zielinski, D Zieminska, L Zivkovic
We report evidence for a narrow structure, X(5568), in the decay sequence X(5568)→B_{s}^{0}π^{±}, B_{s}^{0}→J/ψϕ, J/ψ→μ^{+}μ^{-}, ϕ→K^{+}K^{-}. This is evidence for the first instance of a hadronic state with valence quarks of four different flavors. The mass and natural width of this state are measured to be m=5567.8±2.9(stat)_{-1.9}^{+0.9}(syst)  MeV/c^{2} and Γ=21.9±6.4(stat)_{-2.5}^{+5.0}(syst)  MeV/c^{2}. If the decay is X(5568)→B_{s}^{*}π^{±}→B_{s}^{0}γπ^{±} with an unseen γ, m(X(5568)) will be shifted up by m(B_{s}^{*})-m(B_{s}^{0})∼49  MeV/c^{2}...
July 8, 2016: Physical Review Letters
Christian Fuchsberger, Jason Flannick, Tanya M Teslovich, Anubha Mahajan, Vineeta Agarwala, Kyle J Gaulton, Clement Ma, Pierre Fontanillas, Loukas Moutsianas, Davis J McCarthy, Manuel A Rivas, John R B Perry, Xueling Sim, Thomas W Blackwell, Neil R Robertson, N William Rayner, Pablo Cingolani, Adam E Locke, Juan Fernandez Tajes, Heather M Highland, Josee Dupuis, Peter S Chines, Cecilia M Lindgren, Christopher Hartl, Anne U Jackson, Han Chen, Jeroen R Huyghe, Martijn van de Bunt, Richard D Pearson, Ashish Kumar, Martina Müller-Nurasyid, Niels Grarup, Heather M Stringham, Eric R Gamazon, Jaehoon Lee, Yuhui Chen, Robert A Scott, Jennifer E Below, Peng Chen, Jinyan Huang, Min Jin Go, Michael L Stitzel, Dorota Pasko, Stephen C J Parker, Tibor V Varga, Todd Green, Nicola L Beer, Aaron G Day-Williams, Teresa Ferreira, Tasha Fingerlin, Momoko Horikoshi, Cheng Hu, Iksoo Huh, Mohammad Kamran Ikram, Bong-Jo Kim, Yongkang Kim, Young Jin Kim, Min-Seok Kwon, Juyoung Lee, Selyeong Lee, Keng-Han Lin, Taylor J Maxwell, Yoshihiko Nagai, Xu Wang, Ryan P Welch, Joon Yoon, Weihua Zhang, Nir Barzilai, Benjamin F Voight, Bok-Ghee Han, Christopher P Jenkinson, Teemu Kuulasmaa, Johanna Kuusisto, Alisa Manning, Maggie C Y Ng, Nicholette D Palmer, Beverley Balkau, Alena Stancáková, Hanna E Abboud, Heiner Boeing, Vilmantas Giedraitis, Dorairaj Prabhakaran, Omri Gottesman, James Scott, Jason Carey, Phoenix Kwan, George Grant, Joshua D Smith, Benjamin M Neale, Shaun Purcell, Adam S Butterworth, Joanna M M Howson, Heung Man Lee, Yingchang Lu, Soo-Heon Kwak, Wei Zhao, John Danesh, Vincent K L Lam, Kyong Soo Park, Danish Saleheen, Wing Yee So, Claudia H T Tam, Uzma Afzal, David Aguilar, Rector Arya, Tin Aung, Edmund Chan, Carmen Navarro, Ching-Yu Cheng, Domenico Palli, Adolfo Correa, Joanne E Curran, Denis Rybin, Vidya S Farook, Sharon P Fowler, Barry I Freedman, Michael Griswold, Daniel Esten Hale, Pamela J Hicks, Chiea-Chuen Khor, Satish Kumar, Benjamin Lehne, Dorothée Thuillier, Wei Yen Lim, Jianjun Liu, Yvonne T van der Schouw, Marie Loh, Solomon K Musani, Sobha Puppala, William R Scott, Loïc Yengo, Sian-Tsung Tan, Herman A Taylor, Farook Thameem, Gregory Wilson, Tien Yin Wong, Pål Rasmus Njølstad, Jonathan C Levy, Massimo Mangino, Lori L Bonnycastle, Thomas Schwarzmayr, João Fadista, Gabriela L Surdulescu, Christian Herder, Christopher J Groves, Thomas Wieland, Jette Bork-Jensen, Ivan Brandslund, Cramer Christensen, Heikki A Koistinen, Alex S F Doney, Leena Kinnunen, Tõnu Esko, Andrew J Farmer, Liisa Hakaste, Dylan Hodgkiss, Jasmina Kravic, Valeriya Lyssenko, Mette Hollensted, Marit E Jørgensen, Torben Jørgensen, Claes Ladenvall, Johanne Marie Justesen, Annemari Käräjämäki, Jennifer Kriebel, Wolfgang Rathmann, Lars Lannfelt, Torsten Lauritzen, Narisu Narisu, Allan Linneberg, Olle Melander, Lili Milani, Matt Neville, Marju Orho-Melander, Lu Qi, Qibin Qi, Michael Roden, Olov Rolandsson, Amy Swift, Anders H Rosengren, Kathleen Stirrups, Andrew R Wood, Evelin Mihailov, Christine Blancher, Mauricio O Carneiro, Jared Maguire, Ryan Poplin, Khalid Shakir, Timothy Fennell, Mark DePristo, Martin Hrabé de Angelis, Panos Deloukas, Anette P Gjesing, Goo Jun, Peter Nilsson, Jacquelyn Murphy, Robert Onofrio, Barbara Thorand, Torben Hansen, Christa Meisinger, Frank B Hu, Bo Isomaa, Fredrik Karpe, Liming Liang, Annette Peters, Cornelia Huth, Stephen P O'Rahilly, Colin N A Palmer, Oluf Pedersen, Rainer Rauramaa, Jaakko Tuomilehto, Veikko Salomaa, Richard M Watanabe, Ann-Christine Syvänen, Richard N Bergman, Dwaipayan Bharadwaj, Erwin P Bottinger, Yoon Shin Cho, Giriraj R Chandak, Juliana C N Chan, Kee Seng Chia, Mark J Daly, Shah B Ebrahim, Claudia Langenberg, Paul Elliott, Kathleen A Jablonski, Donna M Lehman, Weiping Jia, Ronald C W Ma, Toni I Pollin, Manjinder Sandhu, Nikhil Tandon, Philippe Froguel, Inês Barroso, Yik Ying Teo, Eleftheria Zeggini, Ruth J F Loos, Kerrin S Small, Janina S Ried, Ralph A DeFronzo, Harald Grallert, Benjamin Glaser, Andres Metspalu, Nicholas J Wareham, Mark Walker, Eric Banks, Christian Gieger, Erik Ingelsson, Hae Kyung Im, Thomas Illig, Paul W Franks, Gemma Buck, Joseph Trakalo, David Buck, Inga Prokopenko, Reedik Mägi, Lars Lind, Yossi Farjoun, Katharine R Owen, Anna L Gloyn, Konstantin Strauch, Tiinamaija Tuomi, Jaspal Singh Kooner, Jong-Young Lee, Taesung Park, Peter Donnelly, Andrew D Morris, Andrew T Hattersley, Donald W Bowden, Francis S Collins, Gil Atzmon, John C Chambers, Timothy D Spector, Markku Laakso, Tim M Strom, Graeme I Bell, John Blangero, Ravindranath Duggirala, E Shyong Tai, Gilean McVean, Craig L Hanis, James G Wilson, Mark Seielstad, Timothy M Frayling, James B Meigs, Nancy J Cox, Rob Sladek, Eric S Lander, Stacey Gabriel, Noël P Burtt, Karen L Mohlke, Thomas Meitinger, Leif Groop, Goncalo Abecasis, Jose C Florez, Laura J Scott, Andrew P Morris, Hyun Min Kang, Michael Boehnke, David Altshuler, Mark I McCarthy
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing in 12,940 individuals from five ancestry groups...
August 4, 2016: Nature
Eleanor M King, Soonita Oomeer, Richard Gilson, Andrew Copas, Simon Beddows, Kate Soldan, Mark Jit, W John Edmunds, Pam Sonnenberg
BACKGROUND: The epidemiology of oral human papillomavirus (HPV) infection in men who have sex with men (MSM) differs from anogenital HPV infection. The impact of HPV vaccination has, to date, largely focussed on anogenital outcomes. Vaccination of MSM in the UK has been recommended and, if implemented, baseline estimates of oral HPV prevalence will be useful. METHODS: We searched Medline, Embase and psycINFO databases for studies reporting prevalence, incidence, and clearance of oral HPV infection in MSM...
2016: PloS One
Karen Ballen, Kwang Woo Ahn, Min Chen, Hisham Abdel-Azim, Ibrahim Ahmed, Mahmoud Aljurf, Joseph Antin, Ami S Bhatt, Michael Boeckh, George Chen, Christopher Dandoy, Biju George, Mary J Laughlin, Hillard M Lazarus, Margaret L MacMillan, David A Margolis, David I Marks, Maxim Norkin, Joseph Rosenthal, Ayman Saad, Bipin Savani, Harry C Schouten, Jan Storek, Paul Szabolcs, Celalettin Ustun, Michael R Verneris, Edmund K Waller, Daniel J Weisdorf, Kirsten M Williams, John R Wingard, Baldeep Wirk, Tom Wolfs, Jo-Anne H Young, Jeffrey Auletta, Krishna V Komanduri, Caroline Lindemans, Marcie L Riches
Alternative graft sources (umbilical cord blood [UCB], matched unrelated donors [MUD], or mismatched unrelated donors [MMUD]) enable patients without a matched sibling donor to receive potentially curative hematopoietic cell transplantation (HCT). Retrospective studies demonstrate comparable outcomes among different graft sources. However, the risk and types of infections have not been compared among graft sources. Such information may influence the choice of a particular graft source. We compared the incidence of bacterial, viral, and fungal infections in 1781 adults with acute leukemia who received alternative donor HCT (UCB, n= 568; MUD, n = 930; MMUD, n = 283) between 2008 and 2011...
September 2016: Biology of Blood and Marrow Transplantation
John B West
When Edmund Hillary and Tenzing Norgay reached the summit of Mt. Everest in 1953, it was the culmination of many attempts beginning in 1921. Alexander Kellas had actually predicted as early as 1920 that the mountain could be climbed, but the extreme altitude of 8848 m with the consequent oxygen deprivation had foiled previous attempts. One reason for the success of the 1953 expedition was the work done by the British physiologist Griffith Pugh in 1952 when he studied many of the physiological factors at high altitude including the oxygen requirements...
2016: Advances in Experimental Medicine and Biology
Raphaëlle Métras, Lisa Cavalerie, Laure Dommergues, Philippe Mérot, W John Edmunds, Matt J Keeling, Catherine Cêtre-Sossah, Eric Cardinale
Rift Valley fever (RVF) is a zoonotic arboviral disease that is a threat to human health, animal health and production, mainly in Sub-Saharan Africa. RVF virus dynamics have been poorly studied due to data scarcity. On the island of Mayotte in the Indian Ocean, off the Southeastern African coast, RVF has been present since at least 2004. Several retrospective and prospective serological surveys in livestock have been conducted over eleven years (2004-15). These data are collated and presented here. Temporal patterns of seroprevalence were plotted against time, as well as age-stratified seroprevalence...
June 2016: PLoS Neglected Tropical Diseases
Edmund Choi, Burt Yazsay, Gregory Mundis, Pooria Hosseini, Jeff Pawelek, Ahmet Alanay, Haluk Berk, Kenneth Cheung, Gokhan Demirkiran, John Ferguson, Tiziana Greggi, Ilkka Helenius, Guido La Rosa, Alpaslan Senkoylu, Behrooz A Akbarnia
BACKGROUND: Traditional growing rods have a reported wound and implant complication rate as high as 58%. It is unclear whether the use of magnetically controlled growing rods (MCGR) will affect this rate. This study was performed to characterize surgical complications following MCGR in early onset scoliosis. METHODS: A multicenter retrospective review of MCGR cases was performed. Inclusion criteria were: (1) diagnosis of early onset scoliosis of any etiology; (2) 10 years and younger at time of index surgery; (3) preoperative major curve size >30 degrees; (4) preoperative thoracic spine height <22 cm...
June 18, 2016: Journal of Pediatric Orthopedics
Kevin M Schartz, Mark T Madsen, John Kim, Riko Ohashi, Kenjirou Ohashi, George Y El-Khoury, Robert T Caldwell, Edmund A Franken, Kevin S Berbaum
PURPOSE: The satisfaction-of-search (SOS) effect occurs when an abnormality on an image is missed because another is found. The aim of this experiment was to test whether severe distracting fractures control the magnitude of SOS on other fractures when both appear in a single CT image. METHODS: The institutional review board approved this study. The experimental (SOS) condition included 35 cervical spine CT cases, all of which contained severe cervical spine injuries...
August 2016: Journal of the American College of Radiology: JACR
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