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John Edmunds

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https://www.readbyqxmd.com/read/29781740/predicting-the-impact-of-pneumococcal-conjugate-vaccine-programme-options-in-vietnam
#1
Olivier Le Polain de Waroux, W John Edmunds, Kensuke Takahashi, Koya Ariyoshi, E Kim Mulholland, David Goldblatt, Yoon Hong Choi, Dang Duc Anh, Lay Myint Yoshida, Stefan Flasche
Although catch-up campaigns (CCs) at the introduction of pneumococcal conjugate vaccines (PCVs) may accelerate their impact, supply constraints may limit their benefit if the need for additional PCV doses results in introduction delay. We studied the impact of PCV13 introduction with and without CC in Nha Trang, Vietnam - a country that has not yet introduced PCV - through a dynamic transmission model. We modelled the impact on carriage and invasive pneumococcal disease (IPD) of routine vaccination (RV) only and that of RV with CCs targeting <1y olds (CC1), <2y olds (CC2) and <5y olds (CC5)...
May 21, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29769071/informal-workers-access-to-health-care-services-findings-from-a-qualitative-study-in-the-kassena-nankana-districts-of-northern-ghana
#2
James Akazili, Samuel Chatio, John Ele-Ojo Ataguba, Isaiah Agorinya, Edmund Wedam Kanmiki, Osman Sankoh, Abraham Oduro
BACKGROUND: Over the past two decades, employment in the informal sector has grown rapidly in all regions including low and middle-income countries. In the developing countries, between 50 and 75% of workers are employed in the informal sector. In Ghana, more than 80% of the total working population is working in the informal sector. They are largely self-employed persons such as farmers, traders, food processors, artisans, craft-workers among others. The persistent problem in advancing efforts to address health vulnerabilities of informal workers is lack of systematic data...
May 16, 2018: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/29749666/adverse-adult-consequences-of-different-alcohol-use-patterns-in-adolescence-an-integrative-analysis-of-data-to-age-30-years-from-four-australasian-cohorts
#3
Edmund Silins, L John Horwood, Jake M Najman, George C Patton, John W Toumbourou, Craig A Olsson, Delyse M Hutchinson, Louisa Degenhardt, David Fergusson, Denise Becker, Joseph M Boden, Rohan Borschmann, Maria Plotnikova, George J Youssef, Robert J Tait, Philip Clare, Wayne D Hall, Richard P Mattick
BACKGROUND AND AIMS: Studies have linked adolescent alcohol use with adverse consequences in adulthood; yet it is unclear how strong the associations are and to what extent they may be due to confounding. Our aim was to estimate the strength of association between different patterns of adolescent drinking and longer-term psychosocial harms taking into account individual, family, and peer factors. DESIGN: Participant-level data were integrated from four long running longitudinal studies: Australian Temperament Project; Christchurch Health and Development Study; Mater Hospital and University of Queensland Study of Pregnancy; Victorian Adolescent Health Cohort Study...
May 10, 2018: Addiction
https://www.readbyqxmd.com/read/29722856/long-term-clinical-outcomes-of-magnetically-navigated-rotor-ablation-as-an-adjunct-to-conventional-pulmonary-vein-isolation
#4
Gunjan Shukla, John Zimmerman, Zoya Shir, Roshan Shah, Edmund Hasanaj
Aims: The objective of this study is to evaluate the outcomes of magnetically guided ablation of atrial fibrillation (AF) rotors in conjunction with magnetically guided pulmonary vein isolation (PVI) in a large consecutive series of patients. Methods and results: A total of 110 consecutive patients with drug-refractory AF underwent rotor ablation followed by conventional PVI and ablation of other spontaneous arrhythmias, all of which were performed with remote magnetic navigation (RMN)...
May 1, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29679008/improving-wood-properties-for-wood-utilization-through-multi-omics-integration-in-lignin-biosynthesis
#5
Jack P Wang, Megan L Matthews, Cranos M Williams, Rui Shi, Chenmin Yang, Sermsawat Tunlaya-Anukit, Hsi-Chuan Chen, Quanzi Li, Jie Liu, Chien-Yuan Lin, Punith Naik, Ying-Hsuan Sun, Philip L Loziuk, Ting-Feng Yeh, Hoon Kim, Erica Gjersing, Todd Shollenberger, Christopher M Shuford, Jina Song, Zachary Miller, Yung-Yun Huang, Charles W Edmunds, Baoguang Liu, Yi Sun, Ying-Chung Jimmy Lin, Wei Li, Hao Chen, Ilona Peszlen, Joel J Ducoste, John Ralph, Hou-Min Chang, David C Muddiman, Mark F Davis, Chris Smith, Fikret Isik, Ronald Sederoff, Vincent L Chiang
A multi-omics quantitative integrative analysis of lignin biosynthesis can advance the strategic engineering of wood for timber, pulp, and biofuels. Lignin is polymerized from three monomers (monolignols) produced by a grid-like pathway. The pathway in wood formation of Populus trichocarpa has at least 21 genes, encoding enzymes that mediate 37 reactions on 24 metabolites, leading to lignin and affecting wood properties. We perturb these 21 pathway genes and integrate transcriptomic, proteomic, fluxomic and phenomic data from 221 lines selected from ~2000 transgenics (6-month-old)...
April 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29626197/proteomic-and-genomic-integration-identifies-kinase-and-differentiation-determinants-of-kinase-inhibitor-sensitivity-in-leukemia-cells
#6
Pedro Casado, Edmund H Wilkes, Farideh Miraki-Moud, Marym Mohammad Hadi, Ana Rio-Machin, Vinothini Rajeeve, Rebecca Pike, Sameena Iqbal, Santiago Marfa, Nicholas Lea, Steven Best, John Gribben, Jude Fitzgibbon, Pedro R Cutillas
No abstract text is available yet for this article.
April 7, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29611508/real-time-modeling-should-be-routinely-integrated-into-outbreak-response
#7
Daniel G Bausch, John Edmunds
No abstract text is available yet for this article.
April 2, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29590092/itaconate-is-an-anti-inflammatory-metabolite-that-activates-nrf2-via-alkylation-of-keap1
#8
Evanna L Mills, Dylan G Ryan, Hiran A Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zaslona, Mark P Jedrychowski, Ana S H Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C Runtsch, Martin S King, Joanna F McGouran, Roman Fischer, Benedikt M Kessler, Anne F McGettrick, Mark M Hughes, Richard G Carroll, Lee M Booty, Elena V Knatko, Paul J Meakin, Michael L J Ashford, Louise K Modis, Gino Brunori, Daniel C Sévin, Padraic G Fallon, Stuart T Caldwell, Edmund R S Kunji, Edward T Chouchani, Christian Frezza, Albena T Dinkova-Kostova, Richard C Hartley, Michael P Murphy, Luke A O'Neill
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood. Here we show that itaconate is required for the activation of the anti-inflammatory transcription factor Nrf2 (also known as NFE2L2) by lipopolysaccharide in mouse and human macrophages. We find that itaconate directly modifies proteins via alkylation of cysteine residues. Itaconate alkylates cysteine residues 151, 257, 288, 273 and 297 on the protein KEAP1, enabling Nrf2 to increase the expression of downstream genes with anti-oxidant and anti-inflammatory capacities...
March 28, 2018: Nature
https://www.readbyqxmd.com/read/29556046/effect-of-fepd-alloy-composition-on-the-dynamics-of-artificial-spin-ice
#9
Sophie A Morley, Susan T Riley, Jose-Maria Porro, Mark C Rosamond, Edmund H Linfield, John E Cunningham, Sean Langridge, Christopher H Marrows
Artificial spin ices (ASI) are arrays of single domain nano-magnetic islands, arranged in geometries that give rise to frustrated magnetostatic interactions. It is possible to reach their ground state via thermal annealing. We have made square ASI using different FePd alloys to vary the magnetization via co-sputtering. From a polarized state the samples were incrementally heated and we measured the vertex population as a function of temperature using magnetic force microscopy. For the higher magnetization FePd sample, we report an onset of dynamics at T = 493 K, with a rapid collapse into >90% ground state vertices...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29553278/patients-discharged-from-the-emergency-department-after-referral-for-hospitalist-admission
#10
Christopher A Caulfield, John Stephens, Zarina Sharalaya, Jeffrey P Laux, Carlton Moore, Daniel E Jonas, Edmund A Liles
OBJECTIVES: To describe the characteristics and outcomes of patients discharged from the emergency department (ED) by hospitalist physicians. STUDY DESIGN: Retrospective cohort study at a tertiary academic medical center. METHODS: We used consultation Current Procedural Technology codes to identify patients discharged from the ED after referral for hospitalist admission from April 2011 to April 2014. We report patient demographics and primary diagnoses...
March 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29551604/ophthalmic-imaging-in-children-current-practice-patterns-and-perceived-barriers
#11
Allison R Loh, Beth Edmunds, John P Campbell, Leah G Reznick, Bibiana J Reiser, David Huang, Michael F Chiang
No abstract text is available yet for this article.
March 15, 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29497684/multicenter-experience-from-the-uk-and-ireland-of-use-of-lumen-apposing-metal-stent-for-transluminal-drainage-of-pancreatic-fluid-collections
#12
Suresh Vasan Venkatachalapathy, Noor Bekkali, Stephen Pereira, Gavin Johnson, Kofi Oppong, Manu Nayar, John Leeds, Bharat Paranandi, Ian Penman, Nicholas Carroll, Edmund Godfrey, Martin James, Guruprasad Aithal, Colin McKay, John Devlin, Terry Wong, Alistair Makin, Barbara Ryan, Matthew Huggett
Background and study aims:  Pancreatic fluid collection (PFC) is a common complication of pancreatitis for which endoscopic ultrasound-guided drainage is first-line treatment. A new single-device, lumen-apposing, covered self-expanding metal stent (LAMS) has been licensed for PFC drainage. We therefore present our multicenter experience with the LAMS for PFC drainage in a multicenter prospective case series to assess success and complication rates. Patients and methods:  All adult patients from 11 tertiary centers who had LAMS placement for PFC from July 2015 to July 2016 were included...
March 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29496658/self-swabbing-for-virological-confirmation-of-influenza-like-illness-among-an-internet-based-cohort-in-the-uk-during-the-2014-2015-flu-season-pilot-study
#13
Clare Wenham, Eleanor R Gray, Candice E Keane, Matthew Donati, Daniela Paolotti, Richard Pebody, Ellen Fragaszy, Rachel A McKendry, W John Edmunds
BACKGROUND: Routine influenza surveillance, based on laboratory confirmation of viral infection, often fails to estimate the true burden of influenza-like illness (ILI) in the community because those with ILI often manage their own symptoms without visiting a health professional. Internet-based surveillance can complement this traditional surveillance by measuring symptoms and health behavior of a population with minimal time delay. Flusurvey, the UK's largest crowd-sourced platform for surveillance of influenza, collects routine data on more than 6000 voluntary participants and offers real-time estimates of ILI circulation...
March 1, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29490281/phlda1-mediates-drug-resistance-in-receptor-tyrosine-kinase-driven-cancer
#14
Abbie E Fearon, Edward P Carter, Natasha S Clayton, Edmund H Wilkes, Ann-Marie Baker, Ekaterina Kapitonova, Bakhouche A Bakhouche, Yasmine Tanner, Jun Wang, Emanuela Gadaleta, Claude Chelala, Kate M Moore, John F Marshall, Juliette Chupin, Peter Schmid, J Louise Jones, Michelle Lockley, Pedro R Cutillas, Richard P Grose
Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to acquisition and maintenance of drug resistance in RTK-driven cancer. Using fibroblast growth factor receptor (FGFR) inhibition in endometrial cancer cells, we identify an Akt-driven compensatory mechanism underpinned by downregulation of PHLDA1. We demonstrate broad clinical relevance of our findings, showing that PHLDA1 downregulation also occurs in response to RTK-targeted therapy in breast and renal cancer patients, as well as following trastuzumab treatment in HER2+ breast cancer cells...
February 27, 2018: Cell Reports
https://www.readbyqxmd.com/read/29487695/rapid-detection-of-brca1-2-recurrent-mutations-in-chinese-breast-and-ovarian-cancer-patients-with-multiplex-snapshot-genotyping-panels
#15
Ava Kwong, John C W Ho, Vivian Y Shin, Allison W Kurian, Edmund Tai, Laura J Esserman, Jeffery N Weitzel, Po-Han Lin, Michael Field, Susan M Domchek, Jessica Lo, Hextan Y S Ngan, Edmond S K Ma, Tsun L Chan, James M Ford
BRCA1/2 mutations are significant risk factors for hereditary breast and ovarian cancer (HBOC), its mutation frequency in HBOC of Chinese ethnicity is around 9%, in which nearly half are recurrent mutations. In Hong Kong and China, genetic testing and counseling are not as common as in the West. To reduce the barrier of testing, a multiplex SNaPshot genotyping panel that targeted 25 Chinese BRCA1/2 mutation hotspots was developed, and its feasibility was evaluated in a local cohort of 441 breast and 155 ovarian cancer patients...
January 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29437406/combined-forward-backward-asymmetry-measurements-in-top-antitop-quark-production-at-the-tevatron
#16
T Aaltonen, V M Abazov, B Abbott, B S Acharya, M Adams, T Adams, J P Agnew, G D Alexeev, G Alkhazov, A Alton, S Amerio, D Amidei, A Anastassov, A Annovi, J Antos, G Apollinari, J A Appel, T Arisawa, A Artikov, J Asaadi, W Ashmanskas, A Askew, S Atkins, B Auerbach, K Augsten, A Aurisano, V Aushev, Y Aushev, C Avila, F Azfar, F Badaud, W Badgett, T Bae, L Bagby, B Baldin, D V Bandurin, S Banerjee, A Barbaro-Galtieri, E Barberis, P Baringer, V E Barnes, B A Barnett, P Barria, J F Bartlett, P Bartos, U Bassler, M Bauce, V Bazterra, A Bean, F Bedeschi, M Begalli, S Behari, L Bellantoni, G Bellettini, J Bellinger, D Benjamin, A Beretvas, S B Beri, G Bernardi, R Bernhard, I Bertram, M Besançon, R Beuselinck, P C Bhat, S Bhatia, V Bhatnagar, A Bhatti, K R Bland, G Blazey, S Blessing, K Bloom, B Blumenfeld, A Bocci, A Bodek, A Boehnlein, D Boline, E E Boos, G Borissov, D Bortoletto, M Borysova, J Boudreau, A Boveia, A Brandt, O Brandt, L Brigliadori, M Brochmann, R Brock, C Bromberg, A Bross, D Brown, E Brucken, X B Bu, J Budagov, H S Budd, M Buehler, V Buescher, V Bunichev, S Burdin, K Burkett, G Busetto, P Bussey, C P Buszello, P Butti, A Buzatu, A Calamba, E Camacho-Pérez, S Camarda, M Campanelli, F Canelli, B Carls, D Carlsmith, R Carosi, S Carrillo, B Casal, M Casarsa, B C K Casey, H Castilla-Valdez, A Castro, P Catastini, S Caughron, D Cauz, V Cavaliere, A Cerri, L Cerrito, S Chakrabarti, K M Chan, A Chandra, A Chapelain, E Chapon, G Chen, Y C Chen, M Chertok, G Chiarelli, G Chlachidze, K Cho, S W Cho, S Choi, D Chokheli, B Choudhary, S Cihangir, D Claes, A Clark, C Clarke, J Clutter, M E Convery, J Conway, M Cooke, W E Cooper, M Corbo, M Corcoran, M Cordelli, F Couderc, M-C Cousinou, C A Cox, D J Cox, M Cremonesi, D Cruz, J Cuevas, R Culbertson, J Cuth, D Cutts, A Das, N d'Ascenzo, M Datta, G Davies, P de Barbaro, S J de Jong, E De La Cruz-Burelo, F Déliot, R Demina, L Demortier, M Deninno, D Denisov, S P Denisov, M D'Errico, S Desai, C Deterre, K DeVaughan, F Devoto, A Di Canto, B Di Ruzza, H T Diehl, M Diesburg, P F Ding, J R Dittmann, A Dominguez, S Donati, M D'Onofrio, M Dorigo, A Driutti, A Drutskoy, A Dubey, L V Dudko, A Duperrin, S Dutt, M Eads, K Ebina, R Edgar, D Edmunds, A Elagin, J Ellison, V D Elvira, Y Enari, R Erbacher, S Errede, B Esham, H Evans, A Evdokimov, V N Evdokimov, S Farrington, A Fauré, L Feng, T Ferbel, J P Fernández Ramos, F Fiedler, R Field, F Filthaut, W Fisher, H E Fisk, G Flanagan, R Forrest, M Fortner, H Fox, J Franc, M Franklin, J C Freeman, H Frisch, S Fuess, Y Funakoshi, C Galloni, P H Garbincius, A Garcia-Bellido, J A García-González, A F Garfinkel, P Garosi, V Gavrilov, W Geng, C E Gerber, H Gerberich, E Gerchtein, Y Gershtein, S Giagu, V Giakoumopoulou, K Gibson, C M Ginsburg, G Ginther, N Giokaris, P Giromini, V Glagolev, D Glenzinski, O Gogota, M Gold, D Goldin, A Golossanov, G Golovanov, G Gomez, G Gomez-Ceballos, M Goncharov, O González López, I Gorelov, A T Goshaw, K Goulianos, E Gramellini, P D Grannis, S Greder, H Greenlee, G Grenier, Ph Gris, J-F Grivaz, A Grohsjean, C Grosso-Pilcher, S Grünendahl, M W Grünewald, T Guillemin, J Guimaraes da Costa, G Gutierrez, P Gutierrez, S R Hahn, J Haley, J Y Han, L Han, F Happacher, K Hara, K Harder, M Hare, A Harel, R F Harr, T Harrington-Taber, K Hatakeyama, J M Hauptman, C Hays, J Hays, T Head, T Hebbeker, D Hedin, H Hegab, J Heinrich, A P Heinson, U Heintz, C Hensel, I Heredia-De La Cruz, M Herndon, K Herner, G Hesketh, M D Hildreth, R Hirosky, T Hoang, J D Hobbs, A Hocker, B Hoeneisen, J Hogan, M Hohlfeld, J L Holzbauer, Z Hong, W Hopkins, S Hou, I Howley, Z Hubacek, R E Hughes, U Husemann, M Hussein, J Huston, V Hynek, I Iashvili, Y Ilchenko, R Illingworth, G Introzzi, M Iori, A S Ito, A Ivanov, S Jabeen, M Jaffré, E James, D Jang, A Jayasinghe, B Jayatilaka, E J Jeon, M S Jeong, R Jesik, P Jiang, S Jindariani, K Johns, E Johnson, M Johnson, A Jonckheere, M Jones, P Jonsson, K K Joo, J Joshi, S Y Jun, A W Jung, T R Junk, A Juste, E Kajfasz, M Kambeitz, T Kamon, P E Karchin, D Karmanov, A Kasmi, Y Kato, I Katsanos, M Kaur, R Kehoe, S Kermiche, W Ketchum, J Keung, N Khalatyan, A Khanov, A Kharchilava, Y N Kharzheev, B Kilminster, D H Kim, H S Kim, J E Kim, M J Kim, S H Kim, S B Kim, Y J Kim, Y K Kim, N Kimura, M Kirby, I Kiselevich, J M Kohli, K Kondo, D J Kong, J Konigsberg, A V Kotwal, A V Kozelov, J Kraus, M Kreps, J Kroll, M Kruse, T Kuhr, A Kumar, A Kupco, M Kurata, T Kurča, V A Kuzmin, A T Laasanen, S Lammel, S Lammers, M Lancaster, K Lannon, G Latino, P Lebrun, H S Lee, H S Lee, J S Lee, S W Lee, W M Lee, X Lei, J Lellouch, S Leo, S Leone, J D Lewis, D Li, H Li, L Li, Q Z Li, J K Lim, A Limosani, D Lincoln, J Linnemann, V V Lipaev, E Lipeles, R Lipton, A Lister, H Liu, Q Liu, T Liu, Y Liu, A Lobodenko, S Lockwitz, A Loginov, M Lokajicek, R Lopes de Sa, D Lucchesi, A Lucà, J Lueck, P Lujan, P Lukens, R Luna-Garcia, G Lungu, A L Lyon, J Lys, R Lysak, A K A Maciel, R Madar, R Madrak, P Maestro, R Magaña-Villalba, S Malik, S Malik, V L Malyshev, G Manca, A Manousakis-Katsikakis, J Mansour, L Marchese, F Margaroli, P Marino, J Martínez-Ortega, K Matera, M E Mattson, A Mazzacane, P Mazzanti, R McCarthy, C L McGivern, R McNulty, A Mehta, P Mehtala, M M Meijer, A Melnitchouk, D Menezes, P G Mercadante, M Merkin, C Mesropian, A Meyer, J Meyer, T Miao, F Miconi, D Mietlicki, A Mitra, H Miyake, S Moed, N Moggi, N K Mondal, C S Moon, R Moore, M J Morello, A Mukherjee, M Mulhearn, Th Muller, P Murat, M Mussini, J Nachtman, Y Nagai, J Naganoma, E Nagy, I Nakano, A Napier, M Narain, R Nayyar, H A Neal, J P Negret, J Nett, P Neustroev, H T Nguyen, T Nigmanov, L Nodulman, S Y Noh, O Norniella, T Nunnemann, L Oakes, S H Oh, Y D Oh, T Okusawa, R Orava, J Orduna, L Ortolan, N Osman, C Pagliarone, A Pal, E Palencia, P Palni, V Papadimitriou, N Parashar, V Parihar, S K Park, W Parker, R Partridge, N Parua, A Patwa, G Pauletta, M Paulini, C Paus, B Penning, M Perfilov, Y Peters, K Petridis, G Petrillo, P Pétroff, T J Phillips, G Piacentino, E Pianori, J Pilot, K Pitts, C Plager, M-A Pleier, V M Podstavkov, L Pondrom, A V Popov, S Poprocki, K Potamianos, A Pranko, M Prewitt, D Price, N Prokopenko, F Prokoshin, F Ptohos, G Punzi, J Qian, A Quadt, B Quinn, P N Ratoff, I Razumov, I Redondo Fernández, P Renton, M Rescigno, F Rimondi, I Ripp-Baudot, L Ristori, F Rizatdinova, A Robson, T Rodriguez, S Rolli, M Rominsky, M Ronzani, R Roser, J L Rosner, A Ross, C Royon, P Rubinov, R Ruchti, F Ruffini, A Ruiz, J Russ, V Rusu, G Sajot, W K Sakumoto, Y Sakurai, A Sánchez-Hernández, M P Sanders, L Santi, A S Santos, K Sato, G Savage, V Saveliev, M Savitskyi, A Savoy-Navarro, L Sawyer, T Scanlon, R D Schamberger, Y Scheglov, H Schellman, P Schlabach, E E Schmidt, M Schott, C Schwanenberger, T Schwarz, R Schwienhorst, L Scodellaro, F Scuri, S Seidel, Y Seiya, J Sekaric, A Semenov, H Severini, F Sforza, E Shabalina, S Z Shalhout, V Shary, S Shaw, A A Shchukin, T Shears, P F Shepard, M Shimojima, O Shkola, M Shochet, I Shreyber-Tecker, V Simak, A Simonenko, P Skubic, P Slattery, K Sliwa, J R Smith, F D Snider, G R Snow, J Snow, S Snyder, S Söldner-Rembold, H Song, L Sonnenschein, V Sorin, K Soustruznik, R St Denis, M Stancari, J Stark, N Stefaniuk, D Stentz, D A Stoyanova, M Strauss, J Strologas, Y Sudo, A Sukhanov, I Suslov, L Suter, P Svoisky, K Takemasa, Y Takeuchi, J Tang, M Tecchio, P K Teng, J Thom, E Thomson, V Thukral, M Titov, D Toback, S Tokar, V V Tokmenin, K Tollefson, T Tomura, D Tonelli, S Torre, D Torretta, P Totaro, M Trovato, Y-T Tsai, D Tsybychev, B Tuchming, C Tully, F Ukegawa, S Uozumi, L Uvarov, S Uvarov, S Uzunyan, R Van Kooten, W M van Leeuwen, N Varelas, E W Varnes, I A Vasilyev, F Vázquez, G Velev, C Vellidis, A Y Verkheev, C Vernieri, L S Vertogradov, M Verzocchi, M Vesterinen, M Vidal, D Vilanova, R Vilar, J Vizán, M Vogel, P Vokac, G Volpi, P Wagner, H D Wahl, R Wallny, M H L S Wang, S M Wang, J Warchol, D Waters, G Watts, M Wayne, J Weichert, L Welty-Rieger, W C Wester, D Whiteson, A B Wicklund, S Wilbur, H H Williams, M R J Williams, G W Wilson, J S Wilson, P Wilson, B L Winer, P Wittich, M Wobisch, S Wolbers, H Wolfmeister, D R Wood, T Wright, X Wu, Z Wu, T R Wyatt, Y Xie, R Yamada, K Yamamoto, D Yamato, S Yang, T Yang, U K Yang, Y C Yang, W-M Yao, T Yasuda, Y A Yatsunenko, W Ye, Z Ye, G P Yeh, K Yi, H Yin, K Yip, J Yoh, K Yorita, T Yoshida, S W Youn, G B Yu, I Yu, J M Yu, A M Zanetti, Y Zeng, J Zennamo, T G Zhao, B Zhou, C Zhou, J Zhu, M Zielinski, D Zieminska, L Zivkovic, S Zucchelli
The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy of sqrt[s]=1.96  TeV. We report the results of combinations of the inclusive asymmetries and their differential dependencies on relevant kinematic quantities. The combined inclusive asymmetry is A_{FB}^{tt[over ¯]}=0...
January 26, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29364886/safety-and-pharmacokinetics-of-the-fc-modified-hiv-1-human-monoclonal-antibody-vrc01ls-a-phase-1-open-label-clinical-trial-in-healthy-adults
#17
Martin R Gaudinski, Emily E Coates, Katherine V Houser, Grace L Chen, Galina Yamshchikov, Jamie G Saunders, LaSonji A Holman, Ingelise Gordon, Sarah Plummer, Cynthia S Hendel, Michelle Conan-Cibotti, Margarita Gomez Lorenzo, Sandra Sitar, Kevin Carlton, Carolyn Laurencot, Robert T Bailer, Sandeep Narpala, Adrian B McDermott, Aryan M Namboodiri, Janardan P Pandey, Richard M Schwartz, Zonghui Hu, Richard A Koup, Edmund Capparelli, Barney S Graham, John R Mascola, Julie E Ledgerwood
BACKGROUND: VRC01 is a human broadly neutralizing monoclonal antibody (bnMAb) against the CD4-binding site of the HIV-1 envelope glycoprotein (Env) that is currently being evaluated in a Phase IIb adult HIV-1 prevention efficacy trial. VRC01LS is a modified version of VRC01, designed for extended serum half-life by increased binding affinity to the neonatal Fc receptor. METHODS AND FINDINGS: This Phase I dose-escalation study of VRC01LS in HIV-negative healthy adults was conducted by the Vaccine Research Center (VRC) at the National Institutes of Health (NIH) Clinical Center (Bethesda, MD)...
January 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29360107/erratum-sequence-data-and-association-statistics-from-12-940-type-2-diabetes-cases-and-controls
#18
Jason Flannick, Christian Fuchsberger, Anubha Mahajan, Tanya M Teslovich, Vineeta Agarwala, Kyle J Gaulton, Lizz Caulkins, Ryan Koesterer, Clement Ma, Loukas Moutsianas, Davis J McCarthy, Manuel A Rivas, John R B Perry, Xueling Sim, Thomas W Blackwell, Neil R Robertson, N William Rayner, Pablo Cingolani, Adam E Locke, Juan Fernandez Tajes, Heather M Highland, Josee Dupuis, Peter S Chines, Cecilia M Lindgren, Christopher Hartl, Anne U Jackson, Han Chen, Jeroen R Huyghe, Martijn van de Bunt, Richard D Pearson, Ashish Kumar, Martina Müller-Nurasyid, Niels Grarup, Heather M Stringham, Eric R Gamazon, Jaehoon Lee, Yuhui Chen, Robert A Scott, Jennifer E Below, Peng Chen, Jinyan Huang, Min Jin Go, Michael L Stitzel, Dorota Pasko, Stephen C J Parker, Tibor V Varga, Todd Green, Nicola L Beer, Aaron G Day-Williams, Teresa Ferreira, Tasha Fingerlin, Momoko Horikoshi, Cheng Hu, Iksoo Huh, Mohammad Kamran Ikram, Bong-Jo Kim, Yongkang Kim, Young Jin Kim, Min-Seok Kwon, Juyoung Lee, Selyeong Lee, Keng-Han Lin, Taylor J Maxwell, Yoshihiko Nagai, Xu Wang, Ryan P Welch, Joon Yoon, Weihua Zhang, Nir Barzilai, Benjamin F Voight, Bok-Ghee Han, Christopher P Jenkinson, Teemu Kuulasmaa, Johanna Kuusisto, Alisa Manning, Maggie C Y Ng, Nicholette D Palmer, Beverley Balkau, Alena Stančáková, Hanna E Abboud, Heiner Boeing, Vilmantas Giedraitis, Dorairaj Prabhakaran, Omri Gottesman, James Scott, Jason Carey, Phoenix Kwan, George Grant, Joshua D Smith, Benjamin M Neale, Shaun Purcell, Adam S Butterworth, Joanna M M Howson, Heung Man Lee, Yingchang Lu, Soo-Heon Kwak, Wei Zhao, John Danesh, Vincent K L Lam, Kyong Soo Park, Danish Saleheen, Wing Yee So, Claudia H T Tam, Uzma Afzal, David Aguilar, Rector Arya, Tin Aung, Edmund Chan, Carmen Navarro, Ching-Yu Cheng, Domenico Palli, Adolfo Correa, Joanne E Curran, Dennis Rybin, Vidya S Farook, Sharon P Fowler, Barry I Freedman, Michael Griswold, Daniel Esten Hale, Pamela J Hicks, Chiea-Chuen Khor, Satish Kumar, Benjamin Lehne, Dorothée Thuillier, Wei Yen Lim, Jianjun Liu, Marie Loh, Solomon K Musani, Sobha Puppala, William R Scott, Loïc Yengo, Sian-Tsung Tan, Herman A Taylor, Farook Thameem, Gregory Wilson, Tien Yin Wong, Pål Rasmus Njølstad, Jonathan C Levy, Massimo Mangino, Lori L Bonnycastle, Thomas Schwarzmayr, João Fadista, Gabriela L Surdulescu, Christian Herder, Christopher J Groves, Thomas Wieland, Jette Bork-Jensen, Ivan Brandslund, Cramer Christensen, Heikki A Koistinen, Alex S F Doney, Leena Kinnunen, Tõnu Esko, Andrew J Farmer, Liisa Hakaste, Dylan Hodgkiss, Jasmina Kravic, Valeri Lyssenko, Mette Hollensted, Marit E Jørgensen, Torben Jørgensen, Claes Ladenvall, Johanne Marie Justesen, Annemari Käräjämäki, Jennifer Kriebel, Wolfgang Rathmann, Lars Lannfelt, Torsten Lauritzen, Narisu Narisu, Allan Linneberg, Olle Melander, Lili Milani, Matt Neville, Marju Orho-Melander, Lu Qi, Qibin Qi, Michael Roden, Olov Rolandsson, Amy Swift, Anders H Rosengren, Kathleen Stirrups, Andrew R Wood, Evelin Mihailov, Christine Blancher, Mauricio O Carneiro, Jared Maguire, Ryan Poplin, Khalid Shakir, Timothy Fennell, Mark DePristo, Martin Hrabé de Angelis, Panos Deloukas, Anette P Gjesing, Goo Jun, Peter Nilsson, Jacquelyn Murphy, Robert Onofrio, Barbara Thorand, Torben Hansen, Christa Meisinger, Frank B Hu, Bo Isomaa, Fredrik Karpe, Liming Liang, Annette Peters, Cornelia Huth, Stephen P O'Rahilly, Colin N A Palmer, Oluf Pedersen, Rainer Rauramaa, Jaakko Tuomilehto, Veikko Salomaa, Richard M Watanabe, Ann-Christine Syvänen, Richard N Bergman, Dwaipayan Bharadwaj, Erwin P Bottinger, Yoon Shin Cho, Giriraj R Chandak, Juliana C N Chan, Kee Seng Chia, Mark J Daly, Shah B Ebrahim, Claudia Langenberg, Paul Elliott, Kathleen A Jablonski, Donna M Lehman, Weiping Jia, Ronald C W Ma, Toni I Pollin, Manjinder Sandhu, Nikhil Tandon, Philippe Froguel, Inês Barroso, Yik Ying Teo, Eleftheria Zeggini, Ruth J F Loos, Kerrin S Small, Janina S Ried, Ralph A DeFronzo, Harald Grallert, Benjamin Glaser, Andres Metspalu, Nicholas J Wareham, Mark Walker, Eric Banks, Christian Gieger, Erik Ingelsson, Hae Kyung Im, Thomas Illig, Paul W Franks, Gemma Buck, Joseph Trakalo, David Buck, Inga Prokopenko, Reedik Mägi, Lars Lind, Yossi Farjoun, Katharine R Owen, Anna L Gloyn, Konstantin Strauch, Tiinamaija Tuomi, Jaspal Singh Kooner, Jong-Young Lee, Taesung Park, Peter Donnelly, Andrew D Morris, Andrew T Hattersley, Donald W Bowden, Francis S Collins, Gil Atzmon, John C Chambers, Timothy D Spector, Markku Laakso, Tim M Strom, Graeme I Bell, John Blangero, Ravindranath Duggirala, E Shyong Tai, Gilean McVean, Craig L Hanis, James G Wilson, Mark Seielstad, Timothy M Frayling, James B Meigs, Nancy J Cox, Rob Sladek, Eric S Lander, Stacey Gabriel, Karen L Mohlke, Thomas Meitinger, Leif Groop, Goncalo Abecasis, Laura J Scott, Andrew P Morris, Hyun Min Kang, David Altshuler, Noël P Burtt, Jose C Florez, Michael Boehnke, Mark I McCarthy
This corrects the article DOI: 10.1038/sdata.2017.179.
January 23, 2018: Scientific Data
https://www.readbyqxmd.com/read/29350150/role-of-environmental-factors-in-shaping-spatial-distribution-of-salmonella-enterica-serovar-typhi-fiji
#19
Ruklanthi de Alwis, Conall Watson, Birgit Nikolay, John H Lowry, Nga Tran Vu Thieu, Tan Trinh Van, Dung Tran Thi Ngoc, Kitione Rawalai, Mere Taufa, Jerimaia Coriakula, Colleen L Lau, Eric J Nilles, W John Edmunds, Mike Kama, Stephen Baker, Jorge Cano
Fiji recently experienced a sharp increase in reported typhoid fever cases. To investigate geographic distribution and environmental risk factors associated with Salmonella enterica serovar Typhi infection, we conducted a cross-sectional cluster survey with associated serologic testing for Vi capsular antigen-specific antibodies (a marker for exposure to Salmonella Typhi in Fiji in 2013. Hotspots with high seroprevalence of Vi-specific antibodies were identified in northeastern mainland Fiji. Risk for Vi seropositivity increased with increased annual rainfall (odds ratio [OR] 1...
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29251578/risk-factors-for-abnormal-cervical-cytology-in-women-undergoing-kidney-transplant-evaluation
#20
Kevin V Chaung, Yu Zheng, Anthony T Martella, Jordan B Stoecker, Devan R Cote, Joshua J Augustine, Edmund Q Sanchez, Vanessa R Humphreville, John B Ammori, Kenneth J Woodside
OBJECTIVES: Cervical cytology screening has been successful in reducing deaths from cervical cancer. We sought to determine risk factors for abnormal Pap test results in women undergoing kidney transplant evaluation. MATERILAS AND METHODS: We retrospectively examined women undergoing kidney transplant evaluations from 2008 to 2011. Patients were stratified based on normal cytology and atypical/malignant cytology. RESULTS: Of 404 patients, 293 patients (72...
December 18, 2017: Experimental and Clinical Transplantation
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