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John Edmunds

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https://www.readbyqxmd.com/read/27926933/comparative-analysis-of-dengue-and-zika-outbreaks-reveals-differences-by-setting-and-virus
#1
Sebastian Funk, Adam J Kucharski, Anton Camacho, Rosalind M Eggo, Laith Yakob, Lawrence M Murray, W John Edmunds
The pacific islands of Micronesia have experienced several outbreaks of mosquito-borne diseases over the past decade. In outbreaks on small islands, the susceptible population is usually well defined, and there is no co-circulation of pathogens. Because of this, analysing such outbreaks can be useful for understanding the transmission dynamics of the pathogens involved, and particularly so for yet understudied pathogens such as Zika virus. Here, we compared three outbreaks of dengue and Zika virus in two different island settings in Micronesia, the Yap Main Islands and Fais, using a mathematical model of transmission dynamics and making full use of commonalities in disease and setting between the outbreaks...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27890468/genetic-overlap-between-attention-deficit-hyperactivity-disorder-and-bipolar-disorder-evidence-from-genome-wide-association-study-meta-analysis
#2
Kimm J E van Hulzen, Claus J Scholz, Barbara Franke, Stephan Ripke, Marieke Klein, Andrew McQuillin, Edmund J Sonuga-Barke, John R Kelsoe, Mikael Landén, Ole A Andreassen, Klaus-Peter Lesch, Heike Weber, Stephen V Faraone, Alejandro Arias-Vasquez, Andreas Reif
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BPD) are frequently co-occurring and highly heritable mental health conditions. We hypothesized that BPD cases with an early age of onset (≤21 years old) would be particularly likely to show genetic covariation with ADHD. METHODS: Genome-wide association study data were available for 4609 individuals with ADHD, 9650 individuals with BPD (5167 thereof with early-onset BPD), and 21,363 typically developing controls...
October 18, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27872709/the-effect-of-sugar-cane-molasses-on-the-immune-and-male-reproductive-systems-using-in-vitro-and-in-vivo-methods
#3
Farzana Rahiman, Edmund John Pool
OBJECTIVES: Sugar cane molasses is a commonly used ingredient in several food products. Contrasting reports suggest that molasses may have potential adverse or beneficial effects on human health. However, little evidence exists that examines the effects of molasses on the different physiological systems. This study investigated the effects of sugar cane molasses on various physiological systems using in vivo and in vitro methods. MATERIALS AND METHODS: Molasses was administered orally to BALB/c, male mice and animals were randomly assigned into either a treatment or control group...
October 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27857425/free-space-terahertz-radiation-from-a-lt-gaas-on-quartz-large-area-photoconductive-emitter
#4
David R Bacon, Andrew D Burnett, Matthew Swithenbank, Christopher Russell, Lianhe Li, Christopher D Wood, John Cunningham, Edmund H Linfield, A Giles Davies, Paul Dean, Joshua R Freeman
We report on large-area photoconductive terahertz (THz) emitters with a low-temperature-grown GaAs (LT-GaAs) active layer fabricated on quartz substrates using a lift-off transfer process. These devices are compared to the same LT-GaAs emitters when fabricated on the growth substrate. We find that the transferred devices show higher optical-to-THz conversion efficiencies and significantly larger breakdown fields, which we attribute to reduced parasitic current in the substrate. Through these improvements, we demonstrate a factor of ~8 increase in emitted THz field strength at the maximum operating voltage...
November 14, 2016: Optics Express
https://www.readbyqxmd.com/read/27824876/understanding-the-role-of-accredited-drug-dispensing-outlets-in-tanzania-s-health-system
#5
Martha Embrey, Catherine Vialle-Valentin, Angel Dillip, Bernard Kihiyo, Romuald Mbwasi, Innocent A Semali, John C Chalker, Jafary Liana, Rachel Lieber, Keith Johnson, Edmund Rutta, Suleiman Kimatta, Elizabeth Shekalaghe, Richard Valimba, Dennis Ross-Degnan
INTRODUCTION: People in many low-income countries access medicines from retail drug shops. In Tanzania, a public-private partnership launched in 2003 used an accreditation approach to improve access to quality medicines and pharmaceutical services in underserved areas. The government scaled up the accredited drug dispensing outlet (ADDO) program nationally, with over 9,000 shops now accredited. This study assessed the relationships between community members and their sources of health care and medicines, particularly antimicrobials, with a specific focus on the role ADDOs play in the health care system...
2016: PloS One
https://www.readbyqxmd.com/read/27821451/phase-i-clinical-trial-results-of-auranofin-a-novel-antiparasitic-agent
#6
Edmund V Capparelli, Robin Bricker-Ford, M John Rogers, James H McKerrow, Sharon L Reed
Under an NIH priority to identify new drugs to treat Class B parasitic agents, we performed high throughput screens, which identified Auranofin's (Ridaura™) activity against Entamoeba histolytica and Giardia intestinalis, major causes of water- and food-borne outbreaks. Auranofin, an oral, gold-containing compound FDA approved in 1985 for rheumatoid arthritis, was effective in vitro and in vivo against E histolytica and both metronidazole-sensitive and resistant strains of Giardia We now report the results of an NIH sponsored Phase I trial to characterize the PK and safety of auranofin in healthy volunteers using modern techniques to measure gold levels...
November 7, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27760326/non-oncogenic-acute-viral-infections-disrupt-anti-cancer-responses-and-lead-to-accelerated-cancer-specific-host-death
#7
Frederick J Kohlhapp, Erica J Huelsmann, Andrew T Lacek, Jason M Schenkel, Jevgenijs Lusciks, Joseph R Broucek, Josef W Goldufsky, Tasha Hughes, Janet P Zayas, Hubert Dolubizno, Ryan T Sowell, Regina Kühner, Sarah Burd, John C Kubasiak, Arman Nabatiyan, Sh'Rae Marshall, Praveen K Bommareddy, Shengguo Li, Jenna H Newman, Claude E Monken, Sasha H Shafikhani, Amanda L Marzo, Jose A Guevara-Patino, Ahmed Lasfar, Paul G Thomas, Edmund C Lattime, Howard L Kaufman, Andrew Zloza
In light of increased cancer prevalence and cancer-specific deaths in patients with infections, we investigated whether infections alter anti-tumor immune responses. We report that acute influenza infection of the lung promotes distal melanoma growth in the dermis and leads to accelerated cancer-specific host death. Furthermore, we show that during influenza infection, anti-melanoma CD8(+) T cells are shunted from the tumor to the infection site, where they express high levels of the inhibitory receptor programmed cell death protein 1 (PD-1)...
October 18, 2016: Cell Reports
https://www.readbyqxmd.com/read/27758873/systems-analysis-uncovers-inflammatory-th-tc17-driven-modules-during-acute-gvhd-in-monkey-and-man
#8
Scott N Furlan, Benjamin Watkins, Victor Tkachev, Sarah Cooley, Angela Panoskaltsis-Mortari, Kayla Betz, Melanie Brown, Daniel J Hunt, John B Schell, Katie Zeleski, Alison Yu, Cindy Giver, Edmund Waller, Jeffrey S Miller, Bruce R Blazar, Leslie S Kean
One of the central challenges of transplantation is the development of alloreactivity despite the use of multi-agent immunoprophylaxis. Effective control of this immune-suppression-resistant T cell activation represents one of the key unmet needs in the fields of both solid organ and hematopoietic stem cell transplant (HCT). To address this unmet need, we have used a highly-translational non-human primate model to interrogate the transcriptional signature of T cells during Breakthrough Acute GVHD that occurs in the setting of clinically-relevant immune suppression and compared this to the Hyperacute GVHD, that develops in unprophylaxed or sub-optimally prophylaxed transplant recipients...
October 6, 2016: Blood
https://www.readbyqxmd.com/read/27741946/assessing-musculoskeletal-examination-skills-and-diagnostic-reasoning-of-4th-year-medical-students-using-a-novel-objective-structured-clinical-exam
#9
R Brent Stansfield, Lisa Diponio, Cliff Craig, John Zeller, Edmund Chadd, Joshua Miller, Seetha Monrad
BACKGROUND: Medical students have difficulty performing and interpreting musculoskeletal physical examinations and interpreting the findings. Research has focused on students' knowledge deficits, but there are few direct assessments of students' ability to perform a hypothesis-driven physical examination (HDPE). We developed a novel musculoskeletal Objective Structured Clinical Exam (OSCE) focusing on HDPE skills for disorders of the shoulder, back and knee, and used it to explore medical student diagnostic reasoning...
October 14, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27727031/the-projected-effectiveness-of-clostridium-difficile-vaccination-as-part-of-an-integrated-infection-control-strategy
#10
Esther van Kleef, Sarah R Deeny, Mark Jit, Barry Cookson, Simon D Goldenberg, W John Edmunds, Julie V Robotham
BACKGROUND: Early clinical trials of a Clostridium difficile toxoid vaccine show efficacy in preventing C. difficile infection (CDI). The optimal patient group to target for vaccination programmes remains unexplored. This study performed a model-based evaluation of the effectiveness of different CDI vaccination strategies, within the context of existing infection prevention and control strategies such as antimicrobial stewardship. METHODS: An individual-based transmission model of CDI in a high-risk hospital setting was developed...
November 4, 2016: Vaccine
https://www.readbyqxmd.com/read/27722909/surface-biotinylation-of-cytotoxic-t-lymphocytes-for-in-vivo-tracking-of-tumor-immunotherapy-in-murine-models
#11
Anning Li, Yue Wu, Jenny Linnoila, Benjamin Pulli, Cuihua Wang, Matthias Zeller, Muhammad Ali, Grant K Lewandrowski, Jinghui Li, Benoit Tricot, Edmund Keliher, Gregory R Wojtkiewicz, Giulia Fulci, Xiaoyuan Feng, Bakhos A Tannous, Zhenwei Yao, John W Chen
Currently, there is no stable and flexible method to label and track cytotoxic T lymphocytes (CTLs) in vivo in CTL immunotherapy. We aimed to evaluate whether the sulfo-hydroxysuccinimide (NHS)-biotin-streptavidin (SA) platform could chemically modify the cell surface of CTLs for in vivo tracking. CD8+ T lymphocytes were labeled with sulfo-NHS-biotin under different conditions and then incubated with SA-Alexa647. Labeling efficiency was proportional to sulfo-NHS-biotin concentration. CD8+ T lymphocytes could be labeled with higher efficiency with sulfo-NHS-biotin in DPBS than in RPMI (P < 0...
December 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27676337/low-risk-of-a-sexually-transmitted-zika-virus-outbreak
#12
Laith Yakob, Adam Kucharski, Stephane Hue, W John Edmunds
No abstract text is available yet for this article.
October 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27633035/impact-of-combined-intermittent-preventive-treatment-of-malaria-and-helminths-on-anaemia-sustained-attention-and-recall-in-northern-ghanaian-schoolchildren
#13
Ernest Cudjoe Opoku, Annette Olsen, Edmund Browne, Abraham Hodgson, John K Awoonor-Williams, Lawrence Yelifari, John Williams, Pascal Magnussen
BACKGROUND: The benefits of integrated control of malaria, schistosomiasis, and soil-transmitted helminth infections have not been fully explored in Ghanaian schoolchildren. OBJECTIVE: To assess the impact of co-administered artemether-lumefantrine plus albendazole, and artemether-lumefantrine plus albendazole plus praziquantel compared to albendazole plus praziquantel on anaemia, sustained attention, and recall in schoolchildren. DESIGN: This three-arm, open-label intervention study was carried out in Ghana among class three schoolchildren...
2016: Global Health Action
https://www.readbyqxmd.com/read/27596135/circulating-progenitor-cells-and-coronary-microvascular-dysfunction-results-from-the-nhlbi-sponsored-women-s-ischemia-syndrome-evaluation-coronary-vascular-dysfunction-study-wise-cvd
#14
Girum Mekonnen, Salim S Hayek, Puja K Mehta, Qunna Li, Ernestine Mahar, Liping Mou, Tanya S Kenkre, John W Petersen, Babak Azarbal, Bruce Samuels, R David Anderson, Tara Sedlak, Melody Zaya, Megha Agarwal, Afsaneh Haftbaradaran, Margo Minissian, Eileen Handberg, Carl J Pepine, Christopher R Cogle, C Noel Bairey Merz, Edmund K Waller, Arshed A Quyyumi
BACKGROUND AND AIMS: Ischemia stimulates a reparative response resulting in mobilization of circulating progenitor cells (CPCs). We hypothesized that women with chronic myocardial ischemia from coronary microvascular disease (CMD) will mobilize CPCs. METHODS: In 123 women with ischemic symptoms and signs but no obstructive coronary artery disease (CAD) enrolled in the Women's Ischemia Syndrome Evaluation - Coronary Vascular Dysfunction Study (WISE-CVD), we measured coronary flow reserve (CFR) in response to intracoronary adenosine...
October 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27580636/a-novel-approach-to-estimation-of-the-time-to-biomarker-threshold-applications-to-hiv
#15
Tarylee Reddy, Geert Molenberghs, Edmund Njeru Njagi, Marc Aerts
In longitudinal studies of biomarkers, an outcome of interest is the time at which a biomarker reaches a particular threshold. The CD4 count is a widely used marker of human immunodeficiency virus progression. Because of the inherent variability of this marker, a single CD4 count below a relevant threshold should be interpreted with caution. Several studies have applied persistence criteria, designating the outcome as the time to the occurrence of two consecutive measurements less than the threshold. In this paper, we propose a method to estimate the time to attainment of two consecutive CD4 counts less than a meaningful threshold, which takes into account the patient-specific trajectory and measurement error...
November 2016: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/27566121/reduced-default-mode-connectivity-in-adolescents-with-conduct-disorder
#16
M John Broulidakis, Graeme Fairchild, Kate Sully, Thomas Blumensath, Angela Darekar, Edmund J S Sonuga-Barke
OBJECTIVE: Conduct disorder (CD) is characterized by impulsive, aggressive, and antisocial behaviors that might be related to deficits in empathy and moral reasoning. The brain's default mode network (DMN) has been implicated in self-referential cognitive processes of this kind. METHOD: This study examined connectivity between key nodes of the DMN in 29 adolescent boys with CD and 29 age- and sex-matched typically developing adolescent boys. The authors ensured that group differences in DMN connectivity were not explained by comorbidity with other disorders by systematically controlling for the effects of substance use disorders (SUDs), attention-deficit/hyperactivity disorder (ADHD) symptoms, psychopathic traits, and other common mental health problems...
September 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27558662/an-assessment-of-the-variation-in-the-concentration-of-acetylcysteine-in-infusions-for-the-treatment-of-paracetamol-overdose
#17
George P Bailey, David M Wood, John R H Archer, Edmund Rab, Robert J Flanagan, Paul I Dargan
BACKGROUND: Intravenous acetylcysteine is the treatment of choice for paracetamol poisoning. A previous UK study in 2001 found that 39% of measured acetylcysteine infusion concentrations differed by >20% from anticipated concentrations. In 2012 the UK Commission on Human Medicines made recommendations for the management of paracetamol overdose, including provision of weight-based acetylcysteine dosing tables. The aim of this study was to assess variation in acetylcysteine concentrations in administered infusions following the introduction of this guidance...
August 24, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27507300/an-approach-to-measuring-and-encouraging-research-translation-and-research-impact
#18
Andrew Searles, Chris Doran, John Attia, Darryl Knight, John Wiggers, Simon Deeming, Joerg Mattes, Brad Webb, Steve Hannan, Rod Ling, Kim Edmunds, Penny Reeves, Michael Nilsson
BACKGROUND: Research translation, particularly in the biomedical area, is often discussed but there are few methods that are routinely used to measure it or its impact. Of the impact measurement methods that are used, most aim to provide accountability - to measure and explain what was generated as a consequence of funding research. This case study reports on the development of a novel, conceptual framework that goes beyond measurement. The Framework To Assess the Impact from Translational health research, or FAIT, is a platform designed to prospectively measure and encourage research translation and research impact...
August 9, 2016: Health Research Policy and Systems
https://www.readbyqxmd.com/read/27447502/evidence-for-a-b_-s-0-%C3%AF-%C3%A2-state
#19
V M Abazov, B Abbott, B S Acharya, M Adams, T Adams, J P Agnew, G D Alexeev, G Alkhazov, A Alton, A Askew, S Atkins, K Augsten, V Aushev, Y Aushev, C Avila, F Badaud, L Bagby, B Baldin, D V Bandurin, S Banerjee, E Barberis, P Baringer, J F Bartlett, U Bassler, V Bazterra, A Bean, M Begalli, L Bellantoni, S B Beri, G Bernardi, R Bernhard, I Bertram, M Besançon, R Beuselinck, P C Bhat, S Bhatia, V Bhatnagar, G Blazey, S Blessing, K Bloom, A Boehnlein, D Boline, E E Boos, G Borissov, M Borysova, A Brandt, O Brandt, M Brochmann, R Brock, A Bross, D Brown, X B Bu, M Buehler, V Buescher, V Bunichev, S Burdin, C P Buszello, E Camacho-Pérez, B C K Casey, H Castilla-Valdez, S Caughron, S Chakrabarti, K M Chan, A Chandra, E Chapon, G Chen, S W Cho, S Choi, B Choudhary, S Cihangir, D Claes, J Clutter, M Cooke, W E Cooper, M Corcoran, F Couderc, M-C Cousinou, J Cuth, D Cutts, A Das, G Davies, S J de Jong, E De La Cruz-Burelo, F Déliot, R Demina, D Denisov, S P Denisov, S Desai, C Deterre, K DeVaughan, H T Diehl, M Diesburg, P F Ding, A Dominguez, A Drutskoy, A Dubey, L V Dudko, A Duperrin, S Dutt, M Eads, D Edmunds, J Ellison, V D Elvira, Y Enari, H Evans, A Evdokimov, V N Evdokimov, A Fauré, L Feng, T Ferbel, F Fiedler, F Filthaut, W Fisher, H E Fisk, M Fortner, H Fox, J Franc, S Fuess, P H Garbincius, A Garcia-Bellido, J A García-González, V Gavrilov, W Geng, C E Gerber, Y Gershtein, G Ginther, O Gogota, G Golovanov, P D Grannis, S Greder, H Greenlee, G Grenier, Ph Gris, J-F Grivaz, A Grohsjean, S Grünendahl, M W Grünewald, T Guillemin, G Gutierrez, P Gutierrez, J Haley, L Han, K Harder, A Harel, J M Hauptman, J Hays, T Head, T Hebbeker, D Hedin, H Hegab, A P Heinson, U Heintz, C Hensel, I Heredia-De La Cruz, K Herner, G Hesketh, M D Hildreth, R Hirosky, T Hoang, J D Hobbs, B Hoeneisen, J Hogan, M Hohlfeld, J L Holzbauer, I Howley, Z Hubacek, V Hynek, I Iashvili, Y Ilchenko, R Illingworth, A S Ito, S Jabeen, M Jaffré, A Jayasinghe, M S Jeong, R Jesik, P Jiang, K Johns, E Johnson, M Johnson, A Jonckheere, P Jonsson, J Joshi, A W Jung, A Juste, E Kajfasz, D Karmanov, I Katsanos, M Kaur, R Kehoe, S Kermiche, N Khalatyan, A Khanov, A Kharchilava, Y N Kharzheev, I Kiselevich, J M Kohli, A V Kozelov, J Kraus, A Kumar, A Kupco, T Kurča, V A Kuzmin, S Lammers, P Lebrun, H S Lee, S W Lee, W M Lee, X Lei, J Lellouch, D Li, H Li, L Li, Q Z Li, J K Lim, D Lincoln, J Linnemann, V V Lipaev, R Lipton, H Liu, Y Liu, A Lobodenko, M Lokajicek, R Lopes de Sa, R Luna-Garcia, A L Lyon, A K A Maciel, R Madar, R Magaña-Villalba, S Malik, V L Malyshev, J Mansour, J Martínez-Ortega, R McCarthy, C L McGivern, M M Meijer, A Melnitchouk, D Menezes, P G Mercadante, M Merkin, A Meyer, J Meyer, F Miconi, N K Mondal, M Mulhearn, E Nagy, M Narain, R Nayyar, H A Neal, J P Negret, P Neustroev, H T Nguyen, T Nunnemann, J Orduna, N Osman, A Pal, N Parashar, V Parihar, S K Park, R Partridge, N Parua, A Patwa, B Penning, M Perfilov, Y Peters, K Petridis, G Petrillo, P Pétroff, M-A Pleier, V M Podstavkov, A V Popov, M Prewitt, D Price, N Prokopenko, J Qian, A Quadt, B Quinn, P N Ratoff, I Razumov, I Ripp-Baudot, F Rizatdinova, M Rominsky, A Ross, C Royon, P Rubinov, R Ruchti, G Sajot, A Sánchez-Hernández, M P Sanders, A S Santos, G Savage, M Savitskyi, L Sawyer, T Scanlon, R D Schamberger, Y Scheglov, H Schellman, M Schott, C Schwanenberger, R Schwienhorst, J Sekaric, H Severini, E Shabalina, V Shary, S Shaw, A A Shchukin, V Simak, P Skubic, P Slattery, G R Snow, J Snow, S Snyder, S Söldner-Rembold, L Sonnenschein, K Soustruznik, J Stark, N Stefaniuk, D A Stoyanova, M Strauss, L Suter, P Svoisky, M Titov, V V Tokmenin, Y-T Tsai, D Tsybychev, B Tuchming, C Tully, L Uvarov, S Uvarov, S Uzunyan, R Van Kooten, W M van Leeuwen, N Varelas, E W Varnes, I A Vasilyev, A Y Verkheev, L S Vertogradov, M Verzocchi, M Vesterinen, D Vilanova, P Vokac, H D Wahl, M H L S Wang, J Warchol, G Watts, M Wayne, J Weichert, L Welty-Rieger, M R J Williams, G W Wilson, M Wobisch, D R Wood, T R Wyatt, Y Xie, R Yamada, S Yang, T Yasuda, Y A Yatsunenko, W Ye, Z Ye, H Yin, K Yip, S W Youn, J M Yu, J Zennamo, T G Zhao, B Zhou, J Zhu, M Zielinski, D Zieminska, L Zivkovic
We report evidence for a narrow structure, X(5568), in the decay sequence X(5568)→B_{s}^{0}π^{±}, B_{s}^{0}→J/ψϕ, J/ψ→μ^{+}μ^{-}, ϕ→K^{+}K^{-}. This is evidence for the first instance of a hadronic state with valence quarks of four different flavors. The mass and natural width of this state are measured to be m=5567.8±2.9(stat)_{-1.9}^{+0.9}(syst)  MeV/c^{2} and Γ=21.9±6.4(stat)_{-2.5}^{+5.0}(syst)  MeV/c^{2}. If the decay is X(5568)→B_{s}^{*}π^{±}→B_{s}^{0}γπ^{±} with an unseen γ, m(X(5568)) will be shifted up by m(B_{s}^{*})-m(B_{s}^{0})∼49  MeV/c^{2}...
July 8, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27398621/the-genetic-architecture-of-type-2-diabetes
#20
Christian Fuchsberger, Jason Flannick, Tanya M Teslovich, Anubha Mahajan, Vineeta Agarwala, Kyle J Gaulton, Clement Ma, Pierre Fontanillas, Loukas Moutsianas, Davis J McCarthy, Manuel A Rivas, John R B Perry, Xueling Sim, Thomas W Blackwell, Neil R Robertson, N William Rayner, Pablo Cingolani, Adam E Locke, Juan Fernandez Tajes, Heather M Highland, Josee Dupuis, Peter S Chines, Cecilia M Lindgren, Christopher Hartl, Anne U Jackson, Han Chen, Jeroen R Huyghe, Martijn van de Bunt, Richard D Pearson, Ashish Kumar, Martina Müller-Nurasyid, Niels Grarup, Heather M Stringham, Eric R Gamazon, Jaehoon Lee, Yuhui Chen, Robert A Scott, Jennifer E Below, Peng Chen, Jinyan Huang, Min Jin Go, Michael L Stitzel, Dorota Pasko, Stephen C J Parker, Tibor V Varga, Todd Green, Nicola L Beer, Aaron G Day-Williams, Teresa Ferreira, Tasha Fingerlin, Momoko Horikoshi, Cheng Hu, Iksoo Huh, Mohammad Kamran Ikram, Bong-Jo Kim, Yongkang Kim, Young Jin Kim, Min-Seok Kwon, Juyoung Lee, Selyeong Lee, Keng-Han Lin, Taylor J Maxwell, Yoshihiko Nagai, Xu Wang, Ryan P Welch, Joon Yoon, Weihua Zhang, Nir Barzilai, Benjamin F Voight, Bok-Ghee Han, Christopher P Jenkinson, Teemu Kuulasmaa, Johanna Kuusisto, Alisa Manning, Maggie C Y Ng, Nicholette D Palmer, Beverley Balkau, Alena Stancáková, Hanna E Abboud, Heiner Boeing, Vilmantas Giedraitis, Dorairaj Prabhakaran, Omri Gottesman, James Scott, Jason Carey, Phoenix Kwan, George Grant, Joshua D Smith, Benjamin M Neale, Shaun Purcell, Adam S Butterworth, Joanna M M Howson, Heung Man Lee, Yingchang Lu, Soo-Heon Kwak, Wei Zhao, John Danesh, Vincent K L Lam, Kyong Soo Park, Danish Saleheen, Wing Yee So, Claudia H T Tam, Uzma Afzal, David Aguilar, Rector Arya, Tin Aung, Edmund Chan, Carmen Navarro, Ching-Yu Cheng, Domenico Palli, Adolfo Correa, Joanne E Curran, Denis Rybin, Vidya S Farook, Sharon P Fowler, Barry I Freedman, Michael Griswold, Daniel Esten Hale, Pamela J Hicks, Chiea-Chuen Khor, Satish Kumar, Benjamin Lehne, Dorothée Thuillier, Wei Yen Lim, Jianjun Liu, Yvonne T van der Schouw, Marie Loh, Solomon K Musani, Sobha Puppala, William R Scott, Loïc Yengo, Sian-Tsung Tan, Herman A Taylor, Farook Thameem, Gregory Wilson, Tien Yin Wong, Pål Rasmus Njølstad, Jonathan C Levy, Massimo Mangino, Lori L Bonnycastle, Thomas Schwarzmayr, João Fadista, Gabriela L Surdulescu, Christian Herder, Christopher J Groves, Thomas Wieland, Jette Bork-Jensen, Ivan Brandslund, Cramer Christensen, Heikki A Koistinen, Alex S F Doney, Leena Kinnunen, Tõnu Esko, Andrew J Farmer, Liisa Hakaste, Dylan Hodgkiss, Jasmina Kravic, Valeriya Lyssenko, Mette Hollensted, Marit E Jørgensen, Torben Jørgensen, Claes Ladenvall, Johanne Marie Justesen, Annemari Käräjämäki, Jennifer Kriebel, Wolfgang Rathmann, Lars Lannfelt, Torsten Lauritzen, Narisu Narisu, Allan Linneberg, Olle Melander, Lili Milani, Matt Neville, Marju Orho-Melander, Lu Qi, Qibin Qi, Michael Roden, Olov Rolandsson, Amy Swift, Anders H Rosengren, Kathleen Stirrups, Andrew R Wood, Evelin Mihailov, Christine Blancher, Mauricio O Carneiro, Jared Maguire, Ryan Poplin, Khalid Shakir, Timothy Fennell, Mark DePristo, Martin Hrabé de Angelis, Panos Deloukas, Anette P Gjesing, Goo Jun, Peter Nilsson, Jacquelyn Murphy, Robert Onofrio, Barbara Thorand, Torben Hansen, Christa Meisinger, Frank B Hu, Bo Isomaa, Fredrik Karpe, Liming Liang, Annette Peters, Cornelia Huth, Stephen P O'Rahilly, Colin N A Palmer, Oluf Pedersen, Rainer Rauramaa, Jaakko Tuomilehto, Veikko Salomaa, Richard M Watanabe, Ann-Christine Syvänen, Richard N Bergman, Dwaipayan Bharadwaj, Erwin P Bottinger, Yoon Shin Cho, Giriraj R Chandak, Juliana C N Chan, Kee Seng Chia, Mark J Daly, Shah B Ebrahim, Claudia Langenberg, Paul Elliott, Kathleen A Jablonski, Donna M Lehman, Weiping Jia, Ronald C W Ma, Toni I Pollin, Manjinder Sandhu, Nikhil Tandon, Philippe Froguel, Inês Barroso, Yik Ying Teo, Eleftheria Zeggini, Ruth J F Loos, Kerrin S Small, Janina S Ried, Ralph A DeFronzo, Harald Grallert, Benjamin Glaser, Andres Metspalu, Nicholas J Wareham, Mark Walker, Eric Banks, Christian Gieger, Erik Ingelsson, Hae Kyung Im, Thomas Illig, Paul W Franks, Gemma Buck, Joseph Trakalo, David Buck, Inga Prokopenko, Reedik Mägi, Lars Lind, Yossi Farjoun, Katharine R Owen, Anna L Gloyn, Konstantin Strauch, Tiinamaija Tuomi, Jaspal Singh Kooner, Jong-Young Lee, Taesung Park, Peter Donnelly, Andrew D Morris, Andrew T Hattersley, Donald W Bowden, Francis S Collins, Gil Atzmon, John C Chambers, Timothy D Spector, Markku Laakso, Tim M Strom, Graeme I Bell, John Blangero, Ravindranath Duggirala, E Shyong Tai, Gilean McVean, Craig L Hanis, James G Wilson, Mark Seielstad, Timothy M Frayling, James B Meigs, Nancy J Cox, Rob Sladek, Eric S Lander, Stacey Gabriel, Noël P Burtt, Karen L Mohlke, Thomas Meitinger, Leif Groop, Goncalo Abecasis, Jose C Florez, Laura J Scott, Andrew P Morris, Hyun Min Kang, Michael Boehnke, David Altshuler, Mark I McCarthy
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing in 12,940 individuals from five ancestry groups...
August 4, 2016: Nature
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