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John Brownstein

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https://www.readbyqxmd.com/read/29776900/the-biopsychosocial-digital-approach-to-health-and-disease-call-for-a-paradigm-expansion
#1
Alireza Ahmadvand, Robert Gatchel, John Brownstein, Lisa Nissen
Digital health is an advancing phenomenon in modern health care systems. Currently, numerous stakeholders in various countries are evaluating the potential benefits of digital health solutions at the individual, population, and/or organizational levels. Additionally, driving factors are being created from the customer-side of the health care systems to push health care providers, policymakers, or researchers to embrace digital health solutions. However, health care providers may differ in their approach to adopt these solutions...
May 18, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29695038/evaluating-the-implementation-of-a-twitter-based-foodborne-illness-reporting-tool-in-the-city-of-st-louis-department-of-health
#2
Jenine K Harris, Leslie Hinyard, Kate Beatty, Jared B Hawkins, Elaine O Nsoesie, Raed Mansour, John S Brownstein
Foodborne illness is a serious and preventable public health problem affecting 1 in 6 Americans with cost estimates over $50 billion annually. Local health departments license and inspect restaurants to ensure food safety and respond to reports of suspected foodborne illness. The City of St. Louis Department of Health adopted the HealthMap Foodborne Dashboard (Dashboard), a tool that monitors Twitter for tweets about food poisoning in a geographic area and allows the health department to respond. We evaluated the implementation by interviewing employees of the City of St...
April 24, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29573962/natural-history-and-management-of-splanchnic-artery-aneurysms-in-a-single-tertiary-referral-center
#3
Young Erben, Adam J Brownstein, Sareh Rajaee, Yupeng Li, John A Rizzo, Hamid Mojibian, Bulat A Ziganshin, John A Elefteriades
OBJECTIVE: Splanchnic artery aneurysms (SAAs) are rare, and little is known about their natural history and management. We reviewed our single-center experience in managing this population of patients. METHODS: A retrospective review of the Yale radiologic database from January 1999 to December 2016 was performed. Only patients with an SAA and a computed tomography scan of the abdomen were selected for review. Demographics of the patients, aneurysm characteristics, management, postoperative complications, and follow-up data were collected...
March 21, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29403102/policy-implications-of-big-data-in-the-health-sector
#4
Effy Vayena, Joan Dzenowagis, John S Brownstein, Aziz Sheikh
No abstract text is available yet for this article.
January 1, 2018: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/29398313/natural-history-and-management-of-renal-artery-aneurysms-in-a-single-tertiary-referral-center
#5
Adam J Brownstein, Young Erben, Sareh Rajaee, Yupeng Li, John A Rizzo, Hamid Mojibian, Bulat A Ziganshin, John A Elefteriades
OBJECTIVE: Although renal artery aneurysms (RAAs) are uncommon, several large reports have been published indicating their benign natural history. The objective of our study was to review our single-center experience managing this disease entity. METHODS: A retrospective review of the Yale radiologic database from January 1999 to December 2016 was performed. Only patients with RAA and a computed tomography scan of the abdomen were selected for review. Demographics of the patients, aneurysm characteristics, management, postoperative complications, and follow-up data were collected...
February 1, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29395211/height-alone-rather-than-body-surface-area-suffices-for-risk-estimation-in-ascending-aortic-aneurysm
#6
Mohammad A Zafar, Yupeng Li, John A Rizzo, Paris Charilaou, Ayman Saeyeldin, Camilo A Velasquez, Ahmed M Mansour, Syed Usman Bin Mahmood, Wei-Guo Ma, Adam J Brownstein, Maryann Tranquilli, Julia Dumfarth, Panagiotis Theodoropoulos, Kabir Thombre, Maryam Tanweer, Young Erben, Sven Peterss, Bulat A Ziganshin, John A Elefteriades
BACKGROUND: In international guidelines, risk estimation for thoracic ascending aortic aneurysm (TAAA) is based on aortic diameter. We previously introduced the aortic size index (ASI), defined as aortic size/body surface area (BSA), as a predictor of aortic dissection, rupture, and death. However, weight might not contribute substantially to aortic size and growth. We seek to evaluate the height-based aortic height index (AHI) versus ASI for risk estimation and revisit our natural history calculations...
May 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29327218/online-communication-about-depression-and-anxiety-among-twitter-users-with-schizophrenia-preliminary-findings-to-inform-a-digital-phenotype-using-social-media
#7
Yulin Hswen, John A Naslund, John S Brownstein, Jared B Hawkins
Digital technologies hold promise for supporting the detection and management of schizophrenia. This exploratory study aimed to generate an initial understanding of whether patterns of communication about depression and anxiety on popular social media among individuals with schizophrenia are consistent with offline representations of the illness. From January to July 2016, posts on Twitter were collected from a sample of Twitter users who self-identify as having a schizophrenia spectrum disorder (n = 203) and a randomly selected sample of control users (n = 173)...
January 12, 2018: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29317382/accurate-influenza-monitoring-and-forecasting-using-novel-internet-data-streams-a-case-study-in-the-boston-metropolis
#8
Fred Sun Lu, Suqin Hou, Kristin Baltrusaitis, Manan Shah, Jure Leskovec, Rok Sosic, Jared Hawkins, John Brownstein, Giuseppe Conidi, Julia Gunn, Josh Gray, Anna Zink, Mauricio Santillana
BACKGROUND: Influenza outbreaks pose major challenges to public health around the world, leading to thousands of deaths a year in the United States alone. Accurate systems that track influenza activity at the city level are necessary to provide actionable information that can be used for clinical, hospital, and community outbreak preparation. OBJECTIVE: Although Internet-based real-time data sources such as Google searches and tweets have been successfully used to produce influenza activity estimates ahead of traditional health care-based systems at national and state levels, influenza tracking and forecasting at finer spatial resolutions, such as the city level, remain an open question...
January 9, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29305342/social-media-impact-of-the-food-and-drug-administration-s-drug-safety-communication-messaging-about-zolpidem-mixed-methods-analysis
#9
Michael S Sinha, Clark C Freifeld, John S Brownstein, Macarius M Donneyong, Paula Rausch, Brian M Lappin, Esther H Zhou, Gerald J Dal Pan, Ajinkya M Pawar, Thomas J Hwang, Jerry Avorn, Aaron S Kesselheim
BACKGROUND: The Food and Drug Administration (FDA) issues drug safety communications (DSCs) to health care professionals, patients, and the public when safety issues emerge related to FDA-approved drug products. These safety messages are disseminated through social media to ensure broad uptake. OBJECTIVE: The objective of this study was to assess the social media dissemination of 2 DSCs released in 2013 for the sleep aid zolpidem. METHODS: We used the MedWatcher Social program and the DataSift historic query tool to aggregate Twitter and Facebook posts from October 1, 2012 through August 31, 2013, a period beginning approximately 3 months before the first DSC and ending 3 months after the second...
January 5, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29249118/endovascular-thoracic-aortic-transection-repair-has-equivalent-survival-to-open-repair-after-blunt-thoracic-aortic-injury
#10
Young Erben, Gerardo Trejo, Adam J Brownstein, Raymond A Jean, Bulat A Ziganshin, Davide Carino, John A Elefteriades, Adrian A Maung
BACKGROUND: Blunt thoracic aortic injury (BTAI) is highly lethal and its management has evolved with the advent of endovascular approaches. We hypothesized that endovascular repair (ER) would have equivalent/improved survival compared to open repair (OR). The aim of our study was to review our center's morbidity and mortality after BTAI. METHODS: Our Level I trauma center registry was queried for BTAI between 2002-2015. This cohort was stratified into three groups: ER, OR and those patients managed non-operatively (NOP)...
April 2018: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29204794/thoracic-aortic-aneurysm-unlocking-the-silent-killer-secrets
#11
Ayman A Saeyeldin, Camilo A Velasquez, Syed Usman B Mahmood, Adam J Brownstein, Mohammad A Zafar, Bulat A Ziganshin, John A Elefteriades
Thoracic aortic aneurysm (TAA) is an increasingly recognized condition that is often diagnosed incidentally. This review discusses ten of the most relevant epidemiological and clinical secrets of this disease; (1) the difference in pathogenesis between ascending and descending TAAs. TAAs at these two sites act as different diseases, which is related to the different embryologic origins of the ascending and descending aorta. (2) The familial pattern and genetics of thoracic aneurysms. Syndromic TAAs only explain 5% of the pattern of inheritance...
December 4, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29196326/massachusetts-dental-schools-respond-to-the-prescription-opioid-crisis-a-statewide-collaboration
#12
David A Keith, Ronald J Kulich, Monica Bharel, Robert E Boose, Jennifer Brownstein, John D Da Silva, Richard D'Innocenzo, R Bruce Donoff, Ellen Factor, Jeffrey W Hutter, Jeffry R Shaefer, Nadeem Y Karimbux, Helen Jack, Huw F Thomas
The prescription opioid crisis has involved all sectors of U.S. society, affecting every community, socioeconomic group, and age group. While federal and state agencies are actively working to deal with the epidemic, medical and dental providers have been tasked to increase their awareness of the issues and consider ways to safely prescribe opioids and, at the same time, effectively treat their patients' pain. The Commonwealth of Massachusetts, under the leadership of Governor Charles D. Baker and his administration, challenged the state's four medical schools and three dental schools to improve their curricula to prepare the next generation of clinicians to deal with this crisis in an evidence-based, effective, and sympathetic way...
December 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/29187641/vasopressin-stimulates-the-proliferation-and-differentiation-of-red-blood-cell-precursors-and-improves-recovery-from-anemia
#13
Balázs Mayer, Krisztián Németh, Miklós Krepuska, Vamsee D Myneni, Dragan Maric, John F Tisdale, Matthew M Hsieh, Naoya Uchida, Heon-Jin Lee, Michael J Nemeth, Kenn Holmbeck, Constance Tom Noguchi, Heather Rogers, Soumyadeep Dey, Arne Hansen, Jeffrey Hong, Ian Chow, Sharon Key, Ildikó Szalayova, Jerome Pagani, Károly Markó, Ian McClain-Caldwell, Lynn Vitale-Cross, W Scott Young, Michael J Brownstein, Éva Mezey
Arginine vasopressin (AVP) made by hypothalamic neurons is released into the circulation to stimulate water resorption by the kidneys and restore water balance after blood loss. Patients who lack this antidiuretic hormone suffer from central diabetes insipidus. We observed that many of these patients were anemic and asked whether AVP might play a role in red blood cell (RBC) production. We found that all three AVP receptors are expressed in human and mouse hematopoietic stem and progenitor cells. The AVPR1B appears to play the most important role in regulating erythropoiesis in both human and mouse cells...
November 29, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29142496/precipitous-resolution-of-type-a-intramural-hematoma-with-medical-management-in-a-patient-with-metastatic-stage-4-renal-cell-carcinoma
#14
Camilo A Velasquez, Syed Usman Bin Mahmood, Mohammad A Zafar, Adam J Brownstein, Ayman Saeyeldin, Bulat A Ziganshin, John A Elefteriades
Intramural hematoma (IMH) is a variant form of aortic dissection characterized by involvement of the aortic media without the presence of an overt intimal flap. Surgical extirpation is the standard of care for type-A IMH in the Western world. However, a conservative approach with anti-impulse therapy has been advocated especially in Japan as a viable alternative. Here, we report a case of an elderly male patient with a history of metastatic stage 4 renal cell carcinoma who was treated with anti-impulse therapy for an acute type-A IMH...
December 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/29092812/combining-participatory-influenza-surveillance-with-modeling-and-forecasting-three-alternative-approaches
#15
John S Brownstein, Shuyu Chu, Achla Marathe, Madhav V Marathe, Andre T Nguyen, Daniela Paolotti, Nicola Perra, Daniela Perrotta, Mauricio Santillana, Samarth Swarup, Michele Tizzoni, Alessandro Vespignani, Anil Kumar S Vullikanti, Mandy L Wilson, Qian Zhang
BACKGROUND: Influenza outbreaks affect millions of people every year and its surveillance is usually carried out in developed countries through a network of sentinel doctors who report the weekly number of Influenza-like Illness cases observed among the visited patients. Monitoring and forecasting the evolution of these outbreaks supports decision makers in designing effective interventions and allocating resources to mitigate their impact. OBJECTIVE: Describe the existing participatory surveillance approaches that have been used for modeling and forecasting of the seasonal influenza epidemic, and how they can help strengthen real-time epidemic science and provide a more rigorous understanding of epidemic conditions...
November 1, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29072150/evaluating-the-relationship-between-hospital-antibiotic-use-and-antibiotic-resistance-in-common-nosocomial-pathogens
#16
Annie Wang, Nick Daneman, Charlie Tan, John S Brownstein, Derek R MacFadden
OBJECTIVE The relationship between hospital antibiotic use and antibiotic resistance is poorly understood. We evaluated the association between antibiotic utilization and resistance in academic and community hospitals in Ontario, Canada. METHODS We conducted a multicenter observational ecological study of 37 hospitals in 2014. Hospital antibiotic purchasing data were used as an indicator of antibiotic use, whereas antibiotic resistance data were extracted from hospital indexes of resistance. Multivariate regression was performed, with antibiotic susceptibility as the primary outcome, antibiotic consumption as the main predictor, and additional covariates of interest (ie, hospital type, laboratory standards, and patient days)...
December 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29044371/nosocomial-amplification-of-mers-coronavirus-in-south-korea-2015
#17
Maimuna S Majumder, John S Brownstein, Stan N Finkelstein, Richard C Larson, Lydia Bourouiba
Background: Nosocomial amplification resulted in nearly 200 cases of Middle East respiratory syndrome (MERS) during the 2015 South Korean MERS-coronavirus outbreak. It remains unclear whether certain types of cases were more likely to cause secondary infections than others, and if so, why. Methods: Publicly available demographic and transmission network data for all cases were collected from the Ministry of Health and Welfare. Statistical analyses were conducted to determine the relationship between demographic characteristics and the likelihood of human-to-human transmission...
June 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29037574/county-level-assessment-of-united-states-kindergarten-vaccination-rates-for-measles-mumps-rubella-mmr-for-the-2014-2015-school-year
#18
Sheryl A Kluberg, Denise P McGinnis, Yulin Hswen, Maimuna S Majumder, Mauricio Santillana, John S Brownstein
United States kindergarten measles-mumps-rubella (MMR) vaccination rates are typically reported at the state level by the Centers for Disease Control and Prevention (CDC). The lack of local MMR data prevents identification of areas with low vaccination rates that would be vulnerable to the spread of disease. We collected county-level vaccination rates for the 2014-2015 school year with the objective of identifying these regions. We requested county-level kindergarten vaccination data from state health departments, and mapped these data to visualize geographic patterns in achievement of the 95% MMR vaccination target...
November 7, 2017: Vaccine
https://www.readbyqxmd.com/read/28934949/online-surveillance-of-media-health-event-reporting-in-nepal-digital-disease-detection-from-a-one-health-perspective
#19
Jessica S Schwind, Stephanie A Norman, Dibesh Karmacharya, David J Wolking, Sameer M Dixit, Rajesh M Rajbhandari, Sumiko R Mekaru, John S Brownstein
BACKGROUND: Traditional media and the internet are crucial sources of health information. Media can significantly shape public opinion, knowledge and understanding of emerging and endemic health threats. As digital communication rapidly progresses, local access and dissemination of health information contribute significantly to global disease detection and reporting. METHODS: Health event reports in Nepal (October 2013-December 2014) were used to characterize Nepal's media environment from a One Health perspective using HealthMap - a global online disease surveillance and mapping tool...
September 21, 2017: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/28877549/a-research-agenda-for-curing-chronic-hepatitis-b-virus-infection
#20
Harvey Alter, Timothy Block, Nathaniel Brown, Alan Brownstein, Carol Brosgart, Kyong-Mi Chang, Pei-Jer Chen, Francis V Chisari, Chari Cohen, Hashem El-Serag, Jordan Feld, Robert Gish, Jeffrey Glenn, Tim Greten, Haitao Guo, Ju-Tao Guo, Yujin Hoshida, Jianming Hu, Kris V Kowdley, Wenhui Li, Jake Liang, Stephan Locarnini, Anna S Lok, William Mason, Brian McMahon, Anand Mehta, Robert Perrillo, Peter Revill, Charles M Rice, JoAnn Rinaudo, Raymond Schinazi, Christoph Seeger, Kirty Shetty, John Tavis, Fabien Zoulim
No abstract text is available yet for this article.
March 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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