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John Brownstein

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https://www.readbyqxmd.com/read/29327218/online-communication-about-depression-and-anxiety-among-twitter-users-with-schizophrenia-preliminary-findings-to-inform-a-digital-phenotype-using-social-media
#1
Yulin Hswen, John A Naslund, John S Brownstein, Jared B Hawkins
Digital technologies hold promise for supporting the detection and management of schizophrenia. This exploratory study aimed to generate an initial understanding of whether patterns of communication about depression and anxiety on popular social media among individuals with schizophrenia are consistent with offline representations of the illness. From January to July 2016, posts on Twitter were collected from a sample of Twitter users who self-identify as having a schizophrenia spectrum disorder (n = 203) and a randomly selected sample of control users (n = 173)...
January 12, 2018: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29317382/accurate-influenza-monitoring-and-forecasting-using-novel-internet-data-streams-a-case-study-in-the-boston-metropolis
#2
Fred Sun Lu, Suqin Hou, Kristin Baltrusaitis, Manan Shah, Jure Leskovec, Rok Sosic, Jared Hawkins, John Brownstein, Giuseppe Conidi, Julia Gunn, Josh Gray, Anna Zink, Mauricio Santillana
BACKGROUND: Influenza outbreaks pose major challenges to public health around the world, leading to thousands of deaths a year in the United States alone. Accurate systems that track influenza activity at the city level are necessary to provide actionable information that can be used for clinical, hospital, and community outbreak preparation. OBJECTIVE: Although Internet-based real-time data sources such as Google searches and tweets have been successfully used to produce influenza activity estimates ahead of traditional health care-based systems at national and state levels, influenza tracking and forecasting at finer spatial resolutions, such as the city level, remain an open question...
January 9, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29305342/social-media-impact-of-the-food-and-drug-administration-s-drug-safety-communication-messaging-about-zolpidem-mixed-methods-analysis
#3
Michael S Sinha, Clark C Freifeld, John S Brownstein, Macarius M Donneyong, Paula Rausch, Brian M Lappin, Esther H Zhou, Gerald J Dal Pan, Ajinkya M Pawar, Thomas J Hwang, Jerry Avorn, Aaron S Kesselheim
BACKGROUND: The Food and Drug Administration (FDA) issues drug safety communications (DSCs) to health care professionals, patients, and the public when safety issues emerge related to FDA-approved drug products. These safety messages are disseminated through social media to ensure broad uptake. OBJECTIVE: The objective of this study was to assess the social media dissemination of 2 DSCs released in 2013 for the sleep aid zolpidem. METHODS: We used the MedWatcher Social program and the DataSift historic query tool to aggregate Twitter and Facebook posts from October 1, 2012 through August 31, 2013, a period beginning approximately 3 months before the first DSC and ending 3 months after the second...
January 5, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29249118/endovascular-thoracic-aortic-transection-repair-has-equivalent-survival-to-open-repair-after-blunt-thoracic-aortic-injury
#4
Young Erben, Gerardo Trejo, Adam J Brownstein, Raymond A Jean, Bulat A Ziganshin, Davide Carino, John A Elefteriades, Adrian A Maung
BACKGROUND: Blunt thoracic aortic injury (BTAI) is highly lethal and its management has evolved with the advent of endovascular approaches. We hypothesized that endovascular repair (ER) would have equivalent/improved survival compared to open repair (OR). The aim of our study was to review our center's morbidity and mortality after BTAI. METHODS: Our Level I trauma center registry was queried for BTAI between 2002-2015. This cohort was stratified into three groups: ER, OR and those patients managed non-operatively (NOP)...
December 13, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29204794/thoracic-aortic-aneurysm-unlocking-the-silent-killer-secrets
#5
Ayman A Saeyeldin, Camilo A Velasquez, Syed Usman B Mahmood, Adam J Brownstein, Mohammad A Zafar, Bulat A Ziganshin, John A Elefteriades
Thoracic aortic aneurysm (TAA) is an increasingly recognized condition that is often diagnosed incidentally. This review discusses ten of the most relevant epidemiological and clinical secrets of this disease; (1) the difference in pathogenesis between ascending and descending TAAs. TAAs at these two sites act as different diseases, which is related to the different embryologic origins of the ascending and descending aorta. (2) The familial pattern and genetics of thoracic aneurysms. Syndromic TAAs only explain 5% of the pattern of inheritance...
December 4, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29196326/massachusetts-dental-schools-respond-to-the-prescription-opioid-crisis-a-statewide-collaboration
#6
David A Keith, Ronald J Kulich, Monica Bharel, Robert E Boose, Jennifer Brownstein, John D Da Silva, Richard D'Innocenzo, R Bruce Donoff, Ellen Factor, Jeffrey W Hutter, Jeffry R Shaefer, Nadeem Y Karimbux, Helen Jack, Huw F Thomas
The prescription opioid crisis has involved all sectors of U.S. society, affecting every community, socioeconomic group, and age group. While federal and state agencies are actively working to deal with the epidemic, medical and dental providers have been tasked to increase their awareness of the issues and consider ways to safely prescribe opioids and, at the same time, effectively treat their patients' pain. The Commonwealth of Massachusetts, under the leadership of Governor Charles D. Baker and his administration, challenged the state's four medical schools and three dental schools to improve their curricula to prepare the next generation of clinicians to deal with this crisis in an evidence-based, effective, and sympathetic way...
December 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/29187641/vasopressin-stimulates-the-proliferation-and-differentiation-of-red-blood-cell-precursors-and-improves-recovery-from-anemia
#7
Balázs Mayer, Krisztián Németh, Miklós Krepuska, Vamsee D Myneni, Dragan Maric, John F Tisdale, Matthew M Hsieh, Naoya Uchida, Heon-Jin Lee, Michael J Nemeth, Kenn Holmbeck, Constance Tom Noguchi, Heather Rogers, Soumyadeep Dey, Arne Hansen, Jeffrey Hong, Ian Chow, Sharon Key, Ildikó Szalayova, Jerome Pagani, Károly Markó, Ian McClain-Caldwell, Lynn Vitale-Cross, W Scott Young, Michael J Brownstein, Éva Mezey
Arginine vasopressin (AVP) made by hypothalamic neurons is released into the circulation to stimulate water resorption by the kidneys and restore water balance after blood loss. Patients who lack this antidiuretic hormone suffer from central diabetes insipidus. We observed that many of these patients were anemic and asked whether AVP might play a role in red blood cell (RBC) production. We found that all three AVP receptors are expressed in human and mouse hematopoietic stem and progenitor cells. The AVPR1B appears to play the most important role in regulating erythropoiesis in both human and mouse cells...
November 29, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29142496/precipitous-resolution-of-type-a-intramural-hematoma-with-medical-management-in-a-patient-with-metastatic-stage-4-renal-cell-carcinoma
#8
Camilo A Velasquez, Syed Usman Bin Mahmood, Mohammad A Zafar, Adam J Brownstein, Ayman Saeyeldin, Bulat A Ziganshin, John A Elefteriades
Intramural hematoma (IMH) is a variant form of aortic dissection characterized by involvement of the aortic media without the presence of an overt intimal flap. Surgical extirpation is the standard of care for type-A IMH in the Western world. However, a conservative approach with anti-impulse therapy has been advocated especially in Japan as a viable alternative. Here, we report a case of an elderly male patient with a history of metastatic stage 4 renal cell carcinoma who was treated with anti-impulse therapy for an acute type-A IMH...
December 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/29092812/combining-participatory-influenza-surveillance-with-modeling-and-forecasting-three-alternative-approaches
#9
John S Brownstein, Shuyu Chu, Achla Marathe, Madhav V Marathe, Andre T Nguyen, Daniela Paolotti, Nicola Perra, Daniela Perrotta, Mauricio Santillana, Samarth Swarup, Michele Tizzoni, Alessandro Vespignani, Anil Kumar S Vullikanti, Mandy L Wilson, Qian Zhang
BACKGROUND: Influenza outbreaks affect millions of people every year and its surveillance is usually carried out in developed countries through a network of sentinel doctors who report the weekly number of Influenza-like Illness cases observed among the visited patients. Monitoring and forecasting the evolution of these outbreaks supports decision makers in designing effective interventions and allocating resources to mitigate their impact. OBJECTIVE: Describe the existing participatory surveillance approaches that have been used for modeling and forecasting of the seasonal influenza epidemic, and how they can help strengthen real-time epidemic science and provide a more rigorous understanding of epidemic conditions...
November 1, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29072150/evaluating-the-relationship-between-hospital-antibiotic-use-and-antibiotic-resistance-in-common-nosocomial-pathogens
#10
Annie Wang, Nick Daneman, Charlie Tan, John S Brownstein, Derek R MacFadden
OBJECTIVE The relationship between hospital antibiotic use and antibiotic resistance is poorly understood. We evaluated the association between antibiotic utilization and resistance in academic and community hospitals in Ontario, Canada. METHODS We conducted a multicenter observational ecological study of 37 hospitals in 2014. Hospital antibiotic purchasing data were used as an indicator of antibiotic use, whereas antibiotic resistance data were extracted from hospital indexes of resistance. Multivariate regression was performed, with antibiotic susceptibility as the primary outcome, antibiotic consumption as the main predictor, and additional covariates of interest (ie, hospital type, laboratory standards, and patient days)...
October 26, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29044371/nosocomial-amplification-of-mers-coronavirus-in-south-korea-2015
#11
Maimuna S Majumder, John S Brownstein, Stan N Finkelstein, Richard C Larson, Lydia Bourouiba
Background: Nosocomial amplification resulted in nearly 200 cases of Middle East respiratory syndrome (MERS) during the 2015 South Korean MERS-coronavirus outbreak. It remains unclear whether certain types of cases were more likely to cause secondary infections than others, and if so, why. Methods: Publicly available demographic and transmission network data for all cases were collected from the Ministry of Health and Welfare. Statistical analyses were conducted to determine the relationship between demographic characteristics and the likelihood of human-to-human transmission...
June 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29037574/county-level-assessment-of-united-states-kindergarten-vaccination-rates-for-measles-mumps-rubella-mmr-for-the-2014-2015-school-year
#12
Sheryl A Kluberg, Denise P McGinnis, Yulin Hswen, Maimuna S Majumder, Mauricio Santillana, John S Brownstein
United States kindergarten measles-mumps-rubella (MMR) vaccination rates are typically reported at the state level by the Centers for Disease Control and Prevention (CDC). The lack of local MMR data prevents identification of areas with low vaccination rates that would be vulnerable to the spread of disease. We collected county-level vaccination rates for the 2014-2015 school year with the objective of identifying these regions. We requested county-level kindergarten vaccination data from state health departments, and mapped these data to visualize geographic patterns in achievement of the 95% MMR vaccination target...
November 7, 2017: Vaccine
https://www.readbyqxmd.com/read/28934949/online-surveillance-of-media-health-event-reporting-in-nepal-digital-disease-detection-from-a-one-health-perspective
#13
Jessica S Schwind, Stephanie A Norman, Dibesh Karmacharya, David J Wolking, Sameer M Dixit, Rajesh M Rajbhandari, Sumiko R Mekaru, John S Brownstein
BACKGROUND: Traditional media and the internet are crucial sources of health information. Media can significantly shape public opinion, knowledge and understanding of emerging and endemic health threats. As digital communication rapidly progresses, local access and dissemination of health information contribute significantly to global disease detection and reporting. METHODS: Health event reports in Nepal (October 2013-December 2014) were used to characterize Nepal's media environment from a One Health perspective using HealthMap - a global online disease surveillance and mapping tool...
September 21, 2017: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/28877549/a-research-agenda-for-curing-chronic-hepatitis-b-virus-infection
#14
Harvey Alter, Timothy M Block, Nathaniel Brown, Alan Brownstein, Carol Brosgart, Kyong-Mi Chang, Pei-Jer Chen, Francis V Chisari, Chari Cohen, Hashem El-Serag, Jordan Feld, Robert Gish, Jeffrey Glenn, Tim Greten, Haitao Guo, Juo-Tao Guo, Yujin Hoshida, Jianming Hu, Kris V Kowdley, Wenhui Li, Jake Liang, Stephen Locarnini, Anna S Lok, William Mason, Brian McMahon, Anand Mehta, Robert Perrillo, Peter Revill, Charles M Rice, JoAnn Rinaudo, Raymond Schinazi, Christoph Seeger, Kirty Shetty, John Tavis, Fabien Zoulim
No abstract text is available yet for this article.
September 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28868310/genes-associated-with-thoracic-aortic-aneurysm-and-dissection-an-update-and-clinical-implications
#15
REVIEW
Adam J Brownstein, Bulat A Ziganshin, Helena Kuivaniemi, Simon C Body, Allen E Bale, John A Elefteriades
Thoracic aortic aneurysm (TAA) is a lethal disease, with a natural history of enlarging progressively until dissection or rupture occurs. Since the discovery almost 20 years ago that ascending TAAs are highly familial, our understanding of the genetics of thoracic aortic aneurysm and dissection (TAAD) has increased exponentially. At least 29 genes have been shown to be associated with the development of TAAD, the majority of which encode proteins involved in the extracellular matrix, smooth muscle cell contraction or metabolism, or the transforming growth factor-β signaling pathway...
February 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/28841509/exploring-online-communication-about-cigarette-smoking-among-twitter-users-who-self-identify-as-having-schizophrenia
#16
Yulin Hswen, John A Naslund, Pooja Chandrashekar, Robert Siegel, John S Brownstein, Jared B Hawkins
Novel approaches are needed to address elevated tobacco use among people with schizophrenia. This exploratory study examined the frequency, timing, and type of communication about tobacco-related content on Twitter among users who self-identify as having schizophrenia compared with users from the general population. Over a 200-day period from January to July 2016, Twitter users who self-identify as having a schizophrenia spectrum disorder (n = 203) and a randomly selected group of general population control users (n = 173) posted 1,544,122 tweets...
August 2, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28830108/a-platform-for-monitoring-regional-antimicrobial-resistance-using-online-data-sources-resistanceopen
#17
Derek R MacFadden, David Fisman, Jeff Andre, Yuki Ara, Maimuna S Majumder, Isaac I Bogoch, Nick Daneman, Annie Wang, Marianna Vavitsas, Lucas Castellani, John S Brownstein
Background: Our understanding of the global burden of antimicrobial resistance is limited. Complementary approaches to antimicrobial resistance surveillance are needed. Methods: We developed a Web-based/mobile platform for aggregating, analyzing, and disseminating regional antimicrobial resistance information. Antimicrobial resistance indices from existing but disparate online sources were identified and abstracted. To validate antimicrobial resistance data, in the absence of regional comparators, US and Canadian indices were aggregated and compared to existing national and state estimates...
December 1, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28804230/the-effect-of-blood-transfusion-on-outcomes-in-aortic-surgery
#18
REVIEW
Camilo A Velasquez, Mrinal Singh, Syed Usman Bin Mahmood, Adam J Brownstein, Mohammad A Zafar, Ayman Saeyeldin, Bulat A Ziganshin, John A Elefteriades
The use of blood transfusion in cardiac surgery varies widely. The beneficial effects of blood products are offset by an increase in morbidity and mortality. Despite multiple studies showing an association between blood product exposure and adverse short- and long-term events, it is difficult to determine causality. Nevertheless, the implication is sufficient to warrant the search for alternative strategies to reduce the use of blood products while providing a standard of care that optimizes postoperative outcomes...
September 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28727821/advances-in-using-internet-searches-to-track-dengue
#19
Shihao Yang, Samuel C Kou, Fred Lu, John S Brownstein, Nicholas Brooke, Mauricio Santillana
Dengue is a mosquito-borne disease that threatens over half of the world's population. Despite being endemic to more than 100 countries, government-led efforts and tools for timely identification and tracking of new infections are still lacking in many affected areas. Multiple methodologies that leverage the use of Internet-based data sources have been proposed as a way to complement dengue surveillance efforts. Among these, dengue-related Google search trends have been shown to correlate with dengue activity...
July 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28719252/severe-fever-with-thrombocytopenia-syndrome-virus-in-humans-domesticated-animals-ticks-and-mosquitoes-shaanxi-province-china
#20
Huaiyu Tian, Pengbo Yu, Gerardo Chowell, Shen Li, Jing Wei, Hui Tian, Wen Lv, Zongqi Han, Jing Yang, Shanqian Huang, Sen Zhou, John S Brownstein, Jingjun Wang, Bing Xu
AbstractThe first human infection with severe fever with thrombocytopenia syndrome virus (SFTSV) was detected in Shaanxi Province, China, in 2013, although the virus had been reported in 13 other provinces of China since 2010. We collected and analyzed a total of 4,011 samples, including 936 human serum samples, 155 animal serum samples, 895 ticks, 1,950 mosquitoes, 30 midges, and 20 sandflies. SFTSV antibodies were found in 44 human samples (4.7%) with no significant differences between males and females or across counties...
June 2017: American Journal of Tropical Medicine and Hygiene
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