Yang Yang, Lixia Liu, Yu Tian, Miaomiao Gu, Yanan Wang, Milad Ashrafizadeh, Amir Reza Aref, Israel Cañadas, Daniel J Klionsky, Arul Goel, Russel J Reiter, Yuzhuo Wang, Murtaza Tambuwala, Jianyong Zou
Despite the challenges posed by drug resistance and side effects, chemotherapy remains a pivotal strategy in cancer treatment. A key issue in this context is macroautophagy (commonly known as autophagy), a dysregulated cell death mechanism often observed during chemotherapy. Autophagy plays a cytoprotective role by maintaining cellular homeostasis and recycling organelles, and emerging evidence points to its significant role in promoting cancer progression. Cisplatin, a DNA-intercalating agent known for inducing cell death and cell cycle arrest, often encounters resistance in chemotherapy treatments...
February 15, 2024: Cancer Letters