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https://www.readbyqxmd.com/read/29035111/identification-of-atopic-dermatitis-phenotypes-with-good-responses-to-probiotics-lactobacillus-plantarum-cjlp133-in-children
#1
J Kim, B S Lee, B Kim, I Na, J Lee, J Y Lee, M R Park, H Kim, I Sohn, K Ahn
The therapeutic effect of probiotics in atopic dermatitis (AD) remains controversial and varies according to the individual patient. We aimed to identify a population of AD patients with a good clinical response to probiotic treatment. We recruited 76 children with a median age of 7.1 years who suffered from moderate to severe AD. After a 2-week washout period, all patients were given Lactobacillus plantarum CJLP133 at a dosage of 1×10(10) colony-forming units once a day for 12 weeks. We measured eosinophil counts in the peripheral blood, the proportion of CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells in CD4(+) T cells, serum total immunoglobulin E (IgE) levels, and specific IgE against common allergens before the start of the treatment (T1) and at discontinuation (T2)...
October 13, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/29033929/immunity-and-fibrogenesis-the-role-of-th17-il-17-axis-in-hbv-and-hcv-induced-chronic-hepatitis-and-progression-to-cirrhosis
#2
REVIEW
Feliciano Chanana Paquissi
Cirrhosis is a common final pathway for most chronic liver diseases; representing an increasing burden worldwide and is associated with increased morbidity and mortality. Current evidence has shown that, after an initial injury, the immune response has a significant participation in the ongoing damage, and progression from chronic viral hepatitis (CVH) to cirrhosis, driving the activation and maintenance of main fibrogenic pathways. Among immune deregulations, those related to the subtype 17 of T helper lymphocytes (Th17)/interleukin-17 (IL-17) axis have been recognized as key immunopathological and prognostic elements in patients with CVH...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29031394/the-role-of-cysteinyl-leukotrienes-and-their-receptors-in-refractory-nasal-polyps
#3
Jintao Du, Luo Ba, Jiao Zhou, Lingyu Yu, Ruowu Liu, Jie Zhang, Feng Liu, Junming Xian, Shixi Liu, Yafeng Liu
Leukotriene signaling is essential in many diseases, including asthma, allergic rhinitis, atherosclerosis and inflammatory bowel disease. Nevertheless, the expression of cysteinyl leukotrienes (CysLTs) and its receptors (CYSLTRs) in different types of nasal polyps (NPs), and the role of their antagonist in the treatment of refractory chronic rhinosinusitis with nasal polyps (CRSwNP) are not well understood. The following study investigates the expression of CysLTs and CYSLTRs in different types of NPs, as well as the role of leukotriene receptor antagonist (montelukast) in refractory NPs...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29029511/mesenchymal-stromal-cells-promote-b-cell-lymphoma-in-lacrimal-glands-by-inducing-immunosuppressive-microenvironment
#4
Min Joung Lee, Se Yeon Park, Jung Hwa Ko, Hyun Ju Lee, Jin Suk Ryu, Jong Woo Park, Sang In Khwarg, Sun-Ok Yoon, Joo Youn Oh
Mesenchymal stromal cells (MSCs) have therapeutic potential for various diseases because of their anti-inflammatory and immunosuppressive properties. However, the immunosuppressive microenvironment allows tumor cells to evade immune surveillance, whereas maintenance of inflammation is required for tumor development and progression. Hence, MSCs may promote or suppress tumors in a context-dependent manner. We here investigated the effects of bone marrow-derived MSCs in a murine model of lacrimal gland B-cell lymphoma...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29026308/role-of-poly-%C3%AE%C2%B5-caprolactone-lipid-core-nanocapsules-on-melanoma-neutrophil-crosstalk
#5
Carine C Drewes, Aline de Cs Alves, Cristina B Hebeda, Isabela Copetti, Silvana Sandri, Mayara K Uchiyama, Koiti Araki, Silvia S Guterres, Adriana R Pohlmann, Sandra H Farsky
Metastatic melanoma is an aggressive cancer with increasing incidence and limited therapies in advanced stages. Systemic neutrophilia or abundant neutrophils in the tumor contribute toward its worst prognosis, and the interplay of cancer and the immune system has been shown in tumor development and metastasis. We recently showed the in vivo efficacy of poly(ε-caprolactone) lipid-core nanocapsule (LNC) or LNC loaded with acetyleugenol (AcE-LNC) to treat B16F10-induced melanoma in mice. In this study, we investigated whether LNC or AcE-LNC toxicity could involve modifications on crosstalk of melanoma cells and neutrophils...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29026214/treatment-with-the-tgf-b-superfamily-cytokine-mic-1-gdf15-reduces-the-adiposity-and-corrects-the-metabolic-dysfunction-of-mice-with-diet-induced-obesity
#6
Vw-W Tsai, H P Zhang, R Manandhar, K K M Lee-Ng, H Lebhar, C P Marquis, Y Husaini, A Sainsbury, D A Brown, S N Breit
OBJECTIVES: To test the potential efficacy of recombinant macrophage inhibitory cytokine-1 (MIC-1/GDF15) as an obesity therapeutic. METHODS: Male C57BL/6J mice, either fed on normal-chow or high-fat-diet for 16 weeks in order to induce diet-induced obesity, were infused with either recombinant MIC-1/GDF15 or vehicle for 34 days by osmotic-mini-pump. During the experimental period metabolic parameters were measured. Blood and tissue were collected for analysis of inflammatory markers...
October 13, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29019702/inhibition-of-phgdh-attenuates-bleomycin-induced-pulmonary-fibrosis
#7
Robert B Hamanaka, Recep Nigdelioglu, Angelo Y Meliton, Yufeng Tian, Leah J Witt, Erin O'Leary, Kaitlyn A Sun, Parker S Woods, David Wu, Brandon Ansbro, Shawn Ard, Jason M Rohde, Nickolai O Dulin, Robert D Guzy, Gökhan M Mutlu
Organ fibrosis, including idiopathic pulmonary fibrosis (IPF), is associated with significant morbidity and mortality. Since currently available therapies have limited effect, there is need to better understand the mechanisms by which organ fibrosis occurs. We have recently reported that TGF-β, a key cytokine which promotes fibrogenesis, induces the expression of the enzymes of the de novo serine and glycine synthesis pathway in human lung fibroblasts and that phosphoglycerate dehydrogenase (PHGDH, the first and rate limiting enzyme of the pathway) is required to promote collagen protein synthesis downstream of TGF-β...
October 11, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29018490/the-promotion-of-nephropathy-by-porphyromonas-gingivalis-lipopolysaccharide-via-toll-like-receptors
#8
Koichiro Kajiwara, Shunsuke Takata, Thao T To, Kenyo Takara, Yuji Hatakeyama, Sachio Tamaoki, Richard Peters Darveau, Hiroyuki Ishikawa, Yoshihiko Sawa
BACKGROUND: Recently, we reported that toll-like receptor (TLR)2 and TLR4 localized on the glomerular endothelium in the glomeruli of streptozotocin (STZ)-induced type 1 diabetic mice and high fat diet feed-induced type 2 diabetic mice, and that periodontal pathogen Porphyromonas gingivalis LPS (Pg-LPS) administration lowered the survival rate of diabetic mice. The present study aims to examine the effect of TLR4 blocking on the suppression of Pg-LPS-induced diabetic nephropathy. METHODS: The survival rate and morphological/biochemical features for streptozotocin-induced diabetic mice with Pg-LPS and TLR4 blocker eritoran administration were investigated by reporter gene assay, urine and blood analysis, immunohistochemistry, and real time-PCR...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29016704/investigation-of-cardiac-fibroblasts-using-myocardial-slices
#9
Filippo Perbellini, Samuel A Watson, Martina Scigliano, Samha Alayoubi, Sebastian Tkach, Ifigeneia Bardi, Nicholas Quaife, Christopher Kane, Neil P Dufton, André Simon, Markus B Sikkel, Giuseppe Faggian, Anna M Randi, Julia Gorelik, Sian E Harding, Cesare M Terracciano
Aims: Cardiac fibroblasts (CFs) are considered the principal regulators of cardiac fibrosis. Factors that influence CF activity are difficult to determine. When isolated and cultured in vitro , CFs undergo rapid phenotypic changes including increased expression of α-SMA. Here we describe a new model to study CFs and their response to pharmacological and mechanical stimuli using in vitro cultured mouse, dog and human myocardial slices. Methods and Results: Unloading of myocardial slices induced CF proliferation without α-SMA expression up to 7 days in culture ...
August 18, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28993461/brucella-abortus-promotes-a-fibrotic-phenotype-in-hepatic-stellate-cells-with-concomitant-autophagy-pathway-activation
#10
Paula Constanza Arriola Benitez, Ayelén Ivana Pesce Viglietti, Claudia Karina Herrmann, Vida A Dennis, Diego José Comerci, Guillermo Hernán Giambartolomei, María Victoria Delpino
The liver is frequently affected in patients with active brucellosis. The present study demonstrates that B. abortus infection induces the activation of the autophagic pathway in hepatic stellate cells to create a microenvironment that promote a profibrogenic phenotype through the induction of transforming growth factor-β1 (TGF-β1), collagen deposition and inhibition of matrix metalloproteinase-9 (MMP-9) secretion. Autophagy was revealed by up-regulation of the LC3II/LC3I ratio and beclin-1 expression as well as inhibition of p62 expression in infected cells...
October 9, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28992620/potential-ameliorative-effects-of-qing-ye-dan-against-cadmium-induced-prostatic-deficits-via-regulating-nrf-2-ho-1-and-tgf-%C3%AE-1-smad-pathways
#11
Lifen Du, Yongfang Lei, Jinglou Chen, Hongping Song, Xinying Wu
BACKGROUND/AIMS: Cadmium (Cd) is an environmental pollutant with reproductive toxicity. Swertia mileensis is used in Chinese medicine for the treatment of prostatic deficits and named as Qing Ye Dan (QYD). This study was undertaken to investigate the potential protective effects of QYD against Cd-induced prostatic deficits. METHOD: Rat model of prostatic deficits was induced by 0.2 mg/kg/d CdCl2 subcutaneous injection for 15 days. The prostatic oxidative stress was evaluated by detecting the levels of malondialdehyde, nitric oxide, reduced/ oxidized glutathione, total sulfhydryl groups and enzymatic antioxidant status...
October 9, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28992293/inducible-overexpression-of-runx1b-c-in-human-embryonic-stem-cells-blocks-early-hematopoiesis-from-mesoderm
#12
B Chen, Jiawen Teng, Hongwei Liu, X Pan, Y Zhou, Shu Huang, Mowen Lai, Guohui Bian, Bin Mao, Wencui Sun, Qiongxiu Zhou, Shengyong Yang, Tatsutoshi Nakahata, Feng Ma
RUNX1 is absolutely required for definitive hematopoiesis, but the function of RUNX1b/c, two isoforms of human RUNX1, is unclear. We established inducible RUNX1b/c-overexpressing human embryonic stem cell (hESC) lines, in which RUNX1b/c overexpression prevented the emergence of CD34+ cells from early stage, thereby drastically reducing the production of hematopoietic stem/progenitor cells. Simultaneously, the expression of hematopoiesis-related factors was downregulated. However, such blockage effect disappeared from day 6 in hESC/AGM-S3 cell co-cultures, proving that the blockage occurred before the generation of hemogenic endothelial cells...
August 1, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28990042/hydroxytyrosol-contributes-to-cell-proliferation-and-inhibits-apoptosis-in-pulsed-electromagnetic-fields-treated-human-umbilical-vein-endothelial-cells-in-vitro
#13
Yong Cheng, Zhiwei Qu, Ximeng Fu, Qi Jiang, Jianfeng Fei
A variety of pulsed electromagnetic fields (PEMFs) have been experimentally and clinically used in an effort to promote wound healing, although the mechanisms involved remain unknown. The aim of the present study was to investigate the action of a novel protocol of co‑treatment with PEMFs and hydroxytyrosol (HTY) on the proliferation and differentiation potential of human umbilical vein endothelial cells (HUVECs). The HUVECs were assigned randomly into three groups: Control, PEMF‑treated and PEMF + HT‑treated...
October 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28986067/counterintuitive-regulatory-t-cell-responses-are-observed-in-senior-patients-with-community-acquired-pneumonia-and-are-related-to-disease-severity
#14
Lu-Qin Bian, Ying Bi, Shao-Wei Zhou, Zi-Dan Chen, Jun Wen, Jin Shi, Ling Mao, Ling Wang
Senior individuals older than 65 years of age are at a disproportionally higher risk of developing pneumonia. Impaired capacity to defend against airway infections may be one of the reasons. It is generally believed that weaker regulatory T cell responses may be beneficial to host defense against pathogens. In senior patients with community-acquired bacterial pneumonia, we investigated the frequencies and functions of regulatory T cells. Interestingly, we found that compared to age- and sex-matched healthy controls, senior pneumonia patients presented lower frequencies of Foxp3-expressing and Helios-expressing CD4(+) T cells...
October 3, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28978694/identification-of-il-40-a-novel-b-cell-associated-cytokine
#15
Jovani Catalan-Dibene, Monica I Vazquez, Van Phi Luu, Sean-Paul Nuccio, Alborz Karimzadeh, Jenna M Kastenschmidt, S Armando Villalta, Irina Ushach, Egest J Pone, Paolo Casali, Manuela Raffatellu, Amanda M Burkhardt, Marcela Hernandez-Ruiz, Gina Heller, Peter A Hevezi, Albert Zlotnik
We describe a novel B cell-associated cytokine, encoded by an uncharacterized gene (C17orf99; chromosome 17 open reading frame 99), that is expressed in bone marrow and fetal liver and whose expression is also induced in peripheral B cells upon activation. C17orf99 is only present in mammalian genomes, and it encodes a small (∼27-kDa) secreted protein unrelated to other cytokine families, suggesting a function in mammalian immune responses. Accordingly, C17orf99 expression is induced in the mammary gland upon the onset of lactation, and a C17orf99(-/-) mouse exhibits reduced levels of IgA in the serum, gut, feces, and lactating mammary gland...
October 4, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28972822/inhibition-of-tgf-%C3%AE-signaling-in-shed-enhances-endothelial-differentiation
#16
J G Xu, T Gong, Y Y Wang, T Zou, B C Heng, Y Q Yang, C F Zhang
Low efficiency of deriving endothelial cells (ECs) from adult stem cells hampers their utilization in tissue engineering studies. The purpose of this study was to investigate whether suppression of transforming growth factor beta (TGF-β) signaling could enhance the differentiation efficiency of dental pulp-derived stem cells into ECs. We initially used vascular endothelial growth factor A (VEGF-A) to stimulate 2 dental pulp-derived stem cells (dental pulp stem cells and stem cells from human exfoliated deciduous teeth [SHED]) and compared their differentiation capacity into ECs...
October 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28965860/hepatic-stellate-cell-targeted-imatinib-nanomedicine-versus-conventional-imatinib-a-novel-strategy-with-potent-efficacy-in-experimental-liver-fibrosis
#17
Nesrine S El-Mezayen, Wessam F El-Hadidy, Wessam M El-Refaie, Th I Shalaby, Mahmoud M Khattab, Aiman S El-Khatib
Liver fibrosis is a global health problem without approved treatment. Imatinib inhibits two key profibrotic pathways; platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-β) and thus can be used to treat liver fibrosis. However, conventional imatinib therapy is hampered by low concentration at target tissue and increased toxicity to other tissues especially heart, lung and liver. Since hepatic stellate cells (HSCs) are the main contributors to liver fibrosis pathogenesis and sole hepatic vitamin A (VA) storage cells, they can be actively targeted by coupling liposomes to VA...
September 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28958480/protein-profiling-and-angiogenic-effect-of-hypoxia-cultured-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-in-hindlimb-ischemia
#18
Kyu-Hyun Han, Ae-Kyeong Kim, Min-Hee Kim, Do-Hyung Kim, Ha-Nl Go, Donglim Kang, Jong Wook Chang, Soon Won Choi, Kyung-Sun Kang, Dong-Ik Kim
The aim of the present study was to investigate protein profiles of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) cultured in normoxic (21% O2) and hypoxic (1% O2) conditions, and evaluate oxygenation effects on angiogenesis in an ischemic hindlimb mouse model using a modified ischemic scoring system. Hypoxic conditions did not change the expression of phenotypic markers and increased adipogenesis and chondrogenesis. Epidermal growth factor (EGF), transforming growth factor alpha (TGF-α), TGF-β RII, and vascular endothelial growth factor (VEGF) were upregulated in the conditioned medium of hypoxic hUCB-MSCs, which are commonly related to angiogenesis and proliferation of biological processes by Gene Ontology...
September 20, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28951703/cutaneous-leukocytoclastic-vasculitis-the-role-of-lymphocytes-and-related-immune-markers
#19
Thilo Gambichler, Magdalena A Kulik, Marina Skrygan, Isabelle Rooms, Stefan Höxtermann
INTRODUCTION: Apart from neutrophils, other immune cells may play a significant pathogenetic role in cutaneous leukocytoclastic vasculitis (CLV). AIM: To investigate lymphocytes and related immunological factors in patients with CLV requiring systemic glucocorticosteroid treatment. MATERIAL AND METHODS: Fourteen patients with severe idiopathic CLV were treated with systemic prednisolone in a tapered dose regimen. Ten healthy individuals served as controls...
August 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28951318/rapidly-progressive-course-of-trypanosoma-cruzi-infection-in-mice-heterozygous-for-hexamethylene-bis-acetamide-inducible-1-hexim1-gene
#20
Eduardo Mascareno, Raavi Gupta, Laura A Martello, Manya Dhar-Mascareno, Louis Salciccioli, Daniel Beckles, Michael G Walsh, Fabiana S Machado, Herbert B Tanowitz, M A Haseeb
Infection with Trypanosoma cruzi causes Chagas disease and results in myocardial inflammation and cardiomyopathy. Downregulated Hexim1 expression, as in Hexim1(+/-) mice, reduces cardiac inflammation and fibrosis following ischemic stress. We asked whether reduced expression of Hexim1 would also afford protection against T. cruzi-induced cardiomyopathy. C57BL/6J (wild type - WT) and Hexim1(+/-) mice were infected with sub-lethal doses of T. cruzi (Brazil strain), and cardiac function, serologic markers of inflammation and tissue pathology were examined...
September 22, 2017: Microbes and Infection
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