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https://www.readbyqxmd.com/read/29222621/lifespan-extension-of-caenorhabditis-elegans-by-butyricicoccus-pullicaecorum-and-megasphaera-elsdenii-with-probiotic-potential
#1
Gayeung Kwon, Jiyun Lee, Jong-Ho Koh, Young-Hee Lim
Butyricicoccus pullicaecorum and Megasphaera elsdenii inhabit the human intestine and have probiotic potential. The aim of this study was to evaluate the effects of B. pullicaecorum and M. elsdenii on the lifespan of Caenorhabditis elegans. They significantly (P < 0.05) extended the lifespan of C. elegans compared with Escherichia coli OP50, a standard food for the worm. Analysis of age-related biomarkers such as lipofuscin, body size, and locomotory activity showed that they retarded aging. They all failed to extend the lifespan of daf-12 or dbl-1 loss-of-function C...
December 8, 2017: Current Microbiology
https://www.readbyqxmd.com/read/29222115/the-methyltransferase-set9-regulates-tgf-b-1-activation-of-renal-fibroblasts-via-interaction-with-smad3
#2
Victoria G Shuttleworth, Luke Gaughan, Lotfia Nawafa, Caitlin A Mooney, Steven L Cobb, Neil S Sheerin, Ian R Logan
Chronic kidney disease (CKD) is a global socioeconomic problem. It is characterised by the presence of differentiated myofibroblasts that, in response to TGF B-1, produce tissue fibrosis, leading to renal failure. Here we define a novel interaction between the SET9 lysine methyltransferase and SMAD3, the principle mediator of TGF B-1 signalling in myofibroblasts. We show that SET9 deficient fibroblasts exhibit globally altered gene expression profiles in response to TGF B-1, whilst overexpression of SET9 enhances SMAD3 transcriptional activity...
December 8, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29217661/foxo3-an-important-player-in-fibrogenesis-and-therapeutic-target-for-idiopathic-pulmonary-fibrosis
#3
Hamza M Al-Tamari, Swati Dabral, Anja Schmall, Pouya Sarvari, Clemens Ruppert, Jihye Paik, Ronald A DePinho, Friedrich Grimminger, Oliver Eickelberg, Andreas Guenther, Werner Seeger, Rajkumar Savai, Soni S Pullamsetti
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal parenchymal lung disease with limited therapeutic options, with fibroblast-to-myofibroblast transdifferentiation and hyperproliferation playing a major role. Investigating ex vivo-cultured (myo)fibroblasts from human IPF lungs as well as fibroblasts isolated from bleomycin-challenged mice, Forkhead box O3 (FoxO3) transcription factor was found to be less expressed, hyperphosphorylated, and nuclear-excluded relative to non-diseased controls. Downregulation and/or hyperphosphorylation of FoxO3 was reproduced by exposure of normal human lung fibroblasts to various pro-fibrotic growth factors and cytokines (FCS, PDGF, IGF1, TGF-β1)...
December 7, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29217273/ltbps-in-biology-and-medicine-ltbp-diseases
#4
REVIEW
Daniel B Rifkin, William J Rifkin, Lior Zilberberg
The latent transforming growth factor (TGF) β binding proteins (LTBP) are crucial mediators of TGFβ function, as they control growth factor secretion, matrix deposition, presentation and activation. Deficiencies in specific LTBP isoforms yield discrete phenotypes representing defects in bone, lung and cardiovascular development mediated by loss of TGFβ signaling. Additional phenotypes represent loss of unique TGFβ-independent features of LTBP effects on elastogenesis and microfibril assembly. Thus, the LTBPs act as sensors for the regulation of both growth factor activity and matrix function...
December 4, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29214350/co-culture-of-human-fibroblasts-and-borrelia-burgdorferi-enhances-collagen-and-growth-factor-mrna
#5
Elisabeth Aberer, Milana Surtov-Pudar, Daniel Wilfinger, Alexander Deutsch, Gerd Leitinger, Helmut Schaider
Skin fibrosis has been reported in Borrelia burgdorferi infection in Europe, but has been questioned by several authors. The objective of the present study was to examine the interaction of skin fibroblasts with B. burgdorferi sensu stricto B31 (BB) and B. afzelii (BA) in vitro by electron microscopy. We also determined the expression of collagen type I, TGF-β, FGF-1, calreticulin (CALR), decorin (DCN), and PDGF-α at the mRNA level in Borrelia/fibroblast co-cultures. Intact Borrelia attach to and transmigrate fibroblasts, and undergo cystic transformation outside the fibroblasts...
December 6, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29214184/protective-effects-of-moringa-oleifera-on-hbv-genotypes-c-and-h-transiently-transfected-huh7-cells
#6
Sina Feustel, Fabiola Ayón-Pérez, Ana Sandoval-Rodriguez, Roberto Rodríguez-Echevarría, Homero Contreras-Salinas, Juan Armendáriz-Borunda, L V Sánchez-Orozco
Chronic hepatitis B infection treatment implicates a long-lasting treatment. M. oleifera extracts contain compounds with antiviral, antioxidant, and antifibrotic properties. In this study, the effect of M. oleifera was evaluated in Huh7 cells expressing either HBV genotypes C or H for the antiviral, antifibrotic, anti-inflammatory, and antioxidative responses. Huh7 cells were treated with an aqueous extract of M. oleifera (leaves) at doses of 0, 30, 45, or 60 μg/mL. The replicative virus and TGF-β1, CTGF, CAT, IFN-β1, and pgRNA expressions were measured by real time...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29214094/study-of-a-two-step-centrifugation-protocol-for-concentrating-cells-and-growth-factors-in-bovine-platelet-rich-plasma
#7
Claudia M Gutiérrez, Catalina López, Carlos E Giraldo, Jorge U Carmona
There is a lack of information about the methods used for bovine platelet-rich plasma (PRP)/platelet-rich gel (PRG) procurement, including information on platelet (PLT), white blood cell (WBC) in PRP, and growth factor release from PRG supernatants. The aims of this study were to compare and to correlate the PLT, WBC, transforming growth factor beta-1 (TGF-β1), and platelet-derived growth factor BB (PDGF-BB) concentrations in bovine whole blood, plasma, and four PRP layers and their respective PRG supernatants: A and B (obtained by a single centrifugation tube method at 720g/5 min) and C and D (obtained by a double centrifugation tube method, by using two centrifugation episodes at 720g/5 min)...
2017: Veterinary Medicine International
https://www.readbyqxmd.com/read/29212195/the-adaptive-immune-system-promotes-initiation-of-prostate-carcinogenesis-in-a-human-c-myc-transgenic-mouse-model
#8
Monique H M Melis, Ekaterina Nevedomskaya, Johan van Burgsteden, Bianca Cioni, Hester J T van Zeeburg, Ji-Ying Song, John Zevenhoven, Lukas J A C Hawinkels, Karin E de Visser, Andries M Bergman
Increasing evidence from epidemiological and pathological studies suggests a role of the immune system in the initiation and progression of multiple cancers, including prostate cancer. Reports on the contribution of the adaptive immune system are contradictive, since both suppression and acceleration of disease development have been reported. This study addresses the functional role of lymphocytes in prostate cancer development using a genetically engineered mouse model (GEMM) of human c-Myc driven prostate cancer (Hi-Myc mice) combined with B and T cell deficiency (RAG1-/- mice)...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211968/men-and-women-differ-in-the-biochemical-composition-of-platelet-rich-plasma
#9
Grace Xiong, Nithya Lingampalli, Jayme C B Koltsov, Lawrence L Leung, Nidhi Bhutani, William H Robinson, Constance R Chu
BACKGROUND: Autologous platelet-rich plasma (PRP) is widely used for a variety of clinical applications. However, clinical outcome studies have not consistently shown positive effects. The composition of PRP differs based on many factors. An improved understanding of factors influencing the composition of PRP is important for the optimization of PRP use. HYPOTHESIS: Age and sex influence the PRP composition in healthy patients. STUDY DESIGN: Controlled laboratory study...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29207359/telbivudine-attenuates-uuo-induced-renal-fibrosis-via-tgf-%C3%AE-smad-and-nf-%C3%AE%C2%BAb-signaling
#10
Jie Chen, Detian Li
Renal fibrosis yields decreased renal function and is a potent contributor to chronic kidney disease (CKD). Telbivudine (LdT) is an anti-hepatitis B virus (HBV) drug that has been found to steadily improve renal function, but the mechanism of drug action is unclear. One explanation is that LdT impacts inflammatory or fibrotic pathways. In this study, we investigated renal protection by LdT in a rat model of unilateral ureteral obstruction (UUO). UUO rats received oral gavage of LdT (1, 1.5, or 2g/kg/day) for 5weeks...
December 2, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29207147/effect-and-mechanism-of-rnai-targeting-wwtr1-on-biological-activity-of-gastric-cancer-cells-sgc7901
#11
Yuan Li, Fang-Liang Yang, Chun-Fu Zhu, Li-Ming Tang
Gastric cancer (GC) is one of the most common malignancies in the world. It is essential to develop novel targets and therapeutic approaches for GC, which requires identification of novel functional molecules. WW‑domain containing transcription regulator 1 (WWTR1) may activate many transcriptional factors and exhibit an important role in the development of various tissues in mammals. The results of the present study demonstrated that mRNA and protein levels of WWTR1 are increased in GC tissues and cell lines...
December 5, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29207033/epigallocatechin-3-gallate-inhibits-inflammation-and-epithelial%C3%A2-mesenchymal-transition-through-the-pi3k-akt-pathway-via-upregulation-of-pten-in-asthma
#12
Nan Yang, Han Zhang, Xuxu Cai, Yunxiao Shang
Asthma is a chronic disease associated with hyperresponsiveness, obstruction and remodeling of the airways. Epithelial-mesenchymal transition (EMT) has an important role in these alterations and may account for the accumulation of subepithelial mesenchymal cells, thus contributing to airway hyperresponsiveness and remodeling. Epigallo-catechin‑3‑gallate (EGCG), which is a type of polyphenol, is the most potent ingredient in green tea, and exhibits antibacterial, antiviral, antioxidative, anticancer and chemopreventive activities...
November 28, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29206819/mechanisms-of-inactivation-of-the-tumour-suppressor-gene-rhoa-in-colorectal-cancer
#13
Higinio Dopeso, Paulo Rodrigues, Josipa Bilic, Sarah Bazzocco, Fernando Cartón-García, Irati Macaya, Priscila Guimarães de Marcondes, Estefanía Anguita, Marc Masanas, Lizbeth M Jiménez-Flores, Águeda Martínez-Barriocanal, Rocío Nieto, Miguel F Segura, Simo Schwartz, John M Mariadason, Diego Arango
BACKGROUND: Reduced RHOA signalling has been shown to increase the growth/metastatic potential of colorectal tumours. However, the mechanisms of inactivation of RHOA signalling in colon cancer have not been characterised. METHODS: A panel of colorectal cancer cell lines and large cohorts of primary tumours were used to investigate the expression and activity of RHOA, as well as the presence of RHOA mutations/deletions and promoter methylation affecting RHOA. Changes in RHOA expression were assessed by western blotting and qPCR after modulation of microRNAs, SMAD4 and c-MYC...
December 5, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29202780/transforming-growth-factor-beta-tgf-%C3%AE-in-adolescent-chronic-fatigue-syndrome
#14
Vegard Bruun Wyller, Chinh Bkrong Nguyen, Judith Anita Ludviksen, Tom Eirik Mollnes
BACKGROUND: Chronic fatigue syndrome (CFS) is a prevalent and disabling condition among adolescent. The disease mechanisms are unknown. Previous studies have suggested elevated plasma levels of several cytokines, but a recent meta-analysis of 38 articles found that of 77 different cytokines measured in plasma, transforming growth factor beta (TGF-β) was the only one that was elevated in patients compared to controls in a sufficient number of articles. In the present study we therefore compared the plasma levels of the three TGF-β isoforms in adolescent CFS patients and healthy controls...
December 4, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29201199/lytak1-attenuates-proliferation-of-retinal-pigment-epithelial-cells-through-tgf-%C3%AE-mediated-epithelial-mesenchymal-transition-via-the-erk-akt-signaling-pathway
#15
Zhen Chen, Ninghua Ni, Yan Mei, Zhengrong Yang
Retinal pigment epithelial (RPE) cells have crucial roles in the initiation and development of human ophthalmic diseases. Our previous study suggested that transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a potential target in the progression and pathogenesis of human proliferative vitreoretinopathy disease. The present study further analyzed the role of TAK1 inhibitor, LYTAK1, in human RPE cells and explored the potential molecular mechanism of LYTAK1-mediated proliferation of human RPE cells...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29198724/monoallelic-bmp2-variants-predicted-to-result-in-haploinsufficiency-cause-craniofacial-skeletal-and-cardiac-features-overlapping-those-of-20p12-deletions
#16
Tiong Yang Tan, Claudia Gonzaga-Jauregui, Elizabeth J Bhoj, Kevin A Strauss, Karlla Brigatti, Erik Puffenberger, Dong Li, LiQin Xie, Nanditha Das, Ioanna Skubas, Ron A Deckelbaum, Virginia Hughes, Susannah Brydges, Sarah Hatsell, Chia-Jen Siao, Melissa G Dominguez, Aris Economides, John D Overton, Valerie Mayne, Peter J Simm, Bryn O Jones, Stefanie Eggers, Gwenaël Le Guyader, Fanny Pelluard, Tobias B Haack, Marc Sturm, Angelika Riess, Stephan Waldmueller, Michael Hofbeck, Katharina Steindl, Pascal Joset, Anita Rauch, Hakon Hakonarson, Naomi L Baker, Peter G Farlie
Bone morphogenetic protein 2 (BMP2) in chromosomal region 20p12 belongs to a gene superfamily encoding TGF-β-signaling proteins involved in bone and cartilage biology. Monoallelic deletions of 20p12 are variably associated with cleft palate, short stature, and developmental delay. Here, we report a cranioskeletal phenotype due to monoallelic truncating and frameshift BMP2 variants and deletions in 12 individuals from eight unrelated families that share features of short stature, a recognizable craniofacial gestalt, skeletal anomalies, and congenital heart disease...
November 23, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29198132/meg3-long-non-coding-rna-prevents-cell-growth-and-metastasis-of-osteosarcoma
#17
S Z Zhang, L Cai, B Li
OBJECTIVE: This study aimed to investigate the role of long non-coding RNA MEG3 (lncRNA MEG3) in osteosarcoma (OS) and further explore the underlying molecular mechanism. MATERIALS AND METHODS: The expression profiles of MEG3 in OS cell lines and normal osteoblast cell line were detected by qRT-PCR. MEG3 was over-expressed in OS cell line by using LV-MEG3. MTT and colony-formation assays were applied for cell proliferation analysis. Cell migration assay was applied to investigate the cell migration ability...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29198125/comparison-between-the-effect-of-kartogenin-and-tgf%C3%AE-3-on-chondrogenesis-of-human-adipose-derived-stem-cells-in-fibrin-scaffold
#18
A Valiani, M A Izadi, H Bahramian, E Esfandiari, B Hashemibeni
BACKGROUND: Due to very sluggish turnover at the molecular and cellular level, the healing of chondral damages has been considered difficult. In the current study, the effects of the Kartogenin, a small heterocyclic molecule on chondrogenic differentiation of stem cells was compared to TGF-β3. METHODS: Human Adipose-Derived Stem Cells were extracted during an elective surgery. Cell viability was estimated by MTT assay, differentiated cells evaluated by histological and immunohistochemical techniques...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29196624/rna-seq-of-serial-kidney-biopsies-obtained-during-progression-of-chronic-kidney-disease-from-dogs-with-x-linked-hereditary-nephropathy
#19
Candice P Chu, Jessica A Hokamp, Rachel E Cianciolo, Alan R Dabney, Candice Brinkmeyer-Langford, George E Lees, Mary B Nabity
Dogs with X-linked hereditary nephropathy (XLHN) have a glomerular basement membrane defect that leads to progressive juvenile-onset renal failure. Their disease is analogous to Alport syndrome in humans, and they also serve as a good model of progressive chronic kidney disease (CKD). However, the gene expression profile that affects progression in this disease has only been partially characterized. To help fill this gap, we used RNA sequencing to identify differentially expressed genes (DEGs), over-represented pathways, and upstream regulators that contribute to kidney disease progression...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29189145/transforming-growth-factor-beta-family-advances-in-vascular-function-and-signaling
#20
Sebastian Gatica, Claudio Cabello-Verrugio, Felipe Simon
This review includes a comprehensive, but succinct, summary on the essentials of TGF-b structure, family members, receptors, and intracellular mediators. Also provided is a select list of original publications that report novel roles and facets of TGF-b in vascular function and signaling in the contexts of health and disease.
November 27, 2017: Current Protein & Peptide Science
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