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https://www.readbyqxmd.com/read/29235506/differential-contributions-of-the-middle-frontal-gyrus-functional-connectivity-to-literacy-and-numeracy
#1
Maki S Koyama, David O'Connor, Zarrar Shehzad, Michael P Milham
Literacy and numeracy equally affect an individual's success in and beyond schools, but these two competencies tend to be separately examined, particularly in neuroimaging studies. The current resting-state fMRI study examined the neural correlates of literacy and numeracy in the same sample of healthy adults. We first used an exploratory "Multivariate Distance Matrix Regression" (MDMR) approach to examine intrinsic functional connectivity (iFC), highlighting the middle frontal gyrus (MFG) for both competencies...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29232069/medicare-program-cy-2018-updates-to-the-quality-payment-program-and-quality-payment-program-extreme-and-uncontrollable-circumstance-policy-for-the-transition-year-final-rule-with-comment-period-and-interim-final-rule-with-comment-period
#2
(no author information available yet)
The Medicare Access and CHIP Reauthorization Act of 2015 (MACRA) established the Quality Payment Program for eligible clinicians. Under the Quality Payment Program, eligible clinicians can participate via one of two tracks: Advanced Alternative Payment Models (APMs); or the Merit-based Incentive Payment System (MIPS). We began implementing the Quality Payment Program through rulemaking for calendar year (CY) 2017. This final rule with comment period provides updates for the second and future years of the Quality Payment Program...
November 16, 2017: Federal Register
https://www.readbyqxmd.com/read/29230329/regionally-specific-regulation-of-sensorimotor-network-connectivity-following-tactile-improvement
#3
Stefanie Heba, Melanie Lenz, Tobias Kalisch, Oliver Höffken, Lauren M Schweizer, Benjamin Glaubitz, Nicolaas A J Puts, Martin Tegenthoff, Hubert R Dinse, Tobias Schmidt-Wilcke
Correlations between inherent, task-free low-frequency fluctuations in the blood oxygenation level-dependent (BOLD) signals of the brain provide a potent tool to delineate its functional architecture in terms of intrinsic functional connectivity (iFC). Still, it remains unclear how iFC is modulated during learning. We employed whole-brain resting-state magnetic resonance imaging prior to and after training-independent repetitive sensory stimulation (rSS), which is known to induce somatosensory cortical reorganization...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/29225336/psychiatric-polygenic-risk-associates-with-cortical-morphology-and-functional-organization-in-aging
#4
Annie Lee, Mojun Shen, Anqi Qiu
Common brain abnormalities in cortical morphology and functional organization are observed in psychiatric disorders and aging, reflecting shared genetic influences. This preliminary study aimed to examine the contribution of a polygenetic risk for psychiatric disorders (PRScross) to aging brain and to identify molecular mechanisms through the use of multimodal brain images, genotypes, and transcriptome data. We showed age-related cortical thinning in bilateral inferior frontal cortex (IFC) and superior temporal gyrus and alterations in the functional connectivity between bilateral IFC and between right IFC and right inferior parietal lobe as a function of PRScross...
December 11, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29208929/the-choice-of-cryopreservation-method-affects-immune-compatibility-of-human-cardiovascular-matrices
#5
Maria Schneider, Christof Stamm, Kelvin G M Brockbank, Ulrich A Stock, Martina Seifert
Conventional frozen cryopreservation (CFC) is currently the gold standard for cardiovascular allograft preservation. However, inflammation and structural deterioration limit transplant durability. Ice-free cryopreservation (IFC) already demonstrated matrix structure preservation combined with attenuated immune responses. In this study, we aim to explore the mechanisms of this diminished immunogenicity in vitro. First, we characterized factors released by human aortic tissue after CFC and IFC. Secondly, we analyzed co-cultures with human peripheral blood mononuclear cells, purified monocytes, T cells and monocyte-derived macrophages to examine functional immune effects triggered by the tissue or released cues...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29198814/a-high-content-imaging-flow-cytometry-approach-to-study-mitochondria-in-t-cells-mitotracker-green-fm-dye-concentration-optimization
#6
Namrata Gautam, Shvetha Sankaran, John A Yason, Kevin S W Tan, Nicholas R J Gascoigne
Mitochondria, the powerhouse of the cell, are known to remodel their membrane structures through the process of fusion or fission. Studies have indicated that T cells adopt different energy metabolic phenotypes, namely oxidative phosphorylation and glycolysis depending on whether they are naïve, effector and memory T cells. It has recently been shown that changes in mitochondrial morphology dictate T cell fate via regulation of their metabolism. Our keen interest in T cell function and metabolism led us to explore and establish a method to study mitochondria in live T cells through a novel high content approach called Imaging Flow Cytometry (IFC)...
November 30, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29186380/impact-of-t-cell-mediated-immune-response-on-xenogeneic-heart-valve-transplantation-short-term-success-and-mid-term-failure
#7
Anna C Biermann, Julia Marzi, Eva Brauchle, Maria Schneider, Angela Kornberger, Sherif Abdelaziz, Julian L Wichmann, Christophe T Arendt, Eike Nagel, Kelvin G M Brockbank, Martina Seifert, Katja Schenke-Layland, Ulrich A Stock
OBJECTIVES: Allogeneic frozen cryopreserved heart valves (allografts or homografts) are commonly used in clinical practice. A major obstacle for their application is the limited availability in particular for paediatrics. Allogeneic large animal studies revealed that alternative ice-free cryopreservation (IFC) results in better matrix preservation and reduced immunogenicity. The objective of this study was to evaluate xenogeneic (porcine) compared with allogeneic (ovine) IFC heart valves in a large animal study...
November 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29177509/repetitive-behaviors-in-autism-are-linked-to-imbalance-of-corticostriatal-connectivity-a-functional-connectivity-mri-study
#8
Angela E Abbott, Annika Linke, Aarti Nair, Afrooz Jahedi, Laura A Alba, Christopher L Keown, Inna Fishman, Ralph-Axel Müller
The neural underpinnings of repetitive behaviors (RBs) in autism spectrum disorders (ASDs), ranging from cognitive to motor characteristics, remain unknown. We assessed RB symptomatology in 50 ASD and 52 typically developing (TD) children and adolescents (ages 8-17 years), examining intrinsic functional connectivity (iFC) of corticostriatal circuitry, which is important for reward-based learning and integration of emotional, cognitive, and motor processing, and considered impaired in ASDs. Connectivity analyses were performed for three functionally distinct striatal seeds (limbic, frontoparietal, motor)...
November 21, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29153950/highly-sensitive-electrochemical-nuclear-factor-kappa-b-aptasensor-based-on-target-induced-dual-signal-ratiometric-and-polymerase-assisted-protein-recycling-amplification-strategy
#9
Kanfu Peng, Pan Xie, Zhe-Han Yang, Ruo Yuan, Keqin Zhang
In this work, an amplified electrochemical ratiometric aptasensor for nuclear factor kappa B (NF-κB) assay based on target binding-triggered ratiometric signal readout and polymerase-assisted protein recycling amplification strategy is described. To demonstrate the effect of "signal-off" and "signal-on" change for the dual-signal electrochemical ratiometric readout, the thiol-hairpin DNA (SH-HD) hybridizes with methylene blue (MB)-modified protection DNA (MB-PD) to form capture probes, which is rationally introduced for the construction of the assay platform...
October 26, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29145074/ratiometric-electrochemical-assay-for-sensitive-detecting-microrna-based-on-dual-amplification-mechanism-of-duplex-specific-nuclease-and-hybridization-chain-reaction
#10
Yan-Hong Yuan, Bao-Zhu Chi, Shao-Hua Wen, Ru-Ping Liang, Zhi-Mei Li, Jian-Ding Qiu
We propose a ratiometric electrochemical assay for detecting microRNA (miRNA) on the basis of dual-amplification mechanism by using distinguishable electrochemical signals from thionine (Thi) and ferrocene (Fc). The thiol-modified and ferrocene-labeled hairpin capture probes (CP) are first immobilized on an Au electrode via Au-S reaction. The target miRNA hybridizes with CP and unfolding the hairpin structure of CP to form miRNA-DNA duplexes. Then, kamchatka crab duplex specific nuclease (DSN) specifically cleaves the DNA in miRNA-DNA duplexes, leading to the release of miRNA and another cleaves cycle, meanwhile, numerous Fc leaves away from the electrode surface and leads to the signal-off of Fc...
November 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29136539/an-examination-of-lower-limb-asymmetry-in-ankle-isometric-force-control
#11
Sheng-Che Yen, Laura C Olsavsky, Caitlin M Cloonan, Amelia R Llanos, Kara J Dwyer, Mohsen Nabian, Amir Bahador Farjadian
While asymmetries have been observed between the dominant and non-dominant legs, it is unclear whether they have different abilities in isometric force control (IFC). The purpose of this study was to compare ankle IFC between the legs. IFC is important for stabilization rather than object manipulation, and people typically use their non-dominant leg for stabilization tasks. Additionally, studies suggested that a limb can better acquire a motor task when the control mechanism of the task is related to what the limb is specialized for...
November 11, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29130772/assessment-of-left-ventricular-function-using-the-myocardial-performance-index-in-term-fetuses-that-develop-intrapartum-compromise
#12
Amal A Alsolai, Larissa N Bligh, Ristan M Greer, Alexander Gooi, Sailesh Kumar
OBJECTIVE: To investigate the relationship between the prelabour left ventricular myocardial Performance Index (LVMPI) and intrapartum fetal compromise (IFC) in low risk term pregnancies. METHODS: A blinded, prospective observational cohort study at the Mater Mother's Hospital, Brisbane, Australia. A cohort of 284 women with uncomplicated singleton pregnancies underwent fortnightly ultrasound from 36 weeks until delivery. The LVMPI was assessed by conventional Doppler ultrasound and correlated with intrapartum outcomes...
November 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29127900/a-reusable-ratiometric-electrochemical-biosensor-on-the-basis-of-the-binding-of-methylene-blue-to-dna-with-alternating-at-base-sequence-for-sensitive-detection-of-adenosine
#13
Lin Cui, Mengfei Lu, Ying Li, Bo Tang, Chun-Yang Zhang
We develop a reusable ratiometric electrochemical biosensor on the basis of the binding of methylene blue (MB) to DNA with alternating AT base sequence for sensitive detection of adenosine. We design a strand 1 with MB-modified thymine (T) base in the proximal 3' termini as the capture probe for its immobilization on the gold electrode and a 3' termini ferrocene (Fc)-modified aptamer for the recognition of adenosine. The hybridization of strand 1 with the aptamer leads to the formation of a double-stranded DNA (dsDNA) and consequently the away of MB from the electrode surface and the close of Fc to the electrode surface, generating a small value of IMB/IFc (IMB and IFc are the peak currents of MB and Fc, respectively)...
November 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29122725/an-imaging-flow-cytometry-method-to-assess-ricin-trafficking-in-a549-human-lung-epithelial-cells
#14
Dominic Jenner, Damien Chong, Nicola Walker, A Christopher Green
The endocytosis and trafficking of ricin in mammalian cells is an important area of research for those producing ricin anti-toxins and other ricin therapeutics. Ricin trafficking is usually observed by fluorescence microscopy techniques. This gives good resolution and leads to a detailed understanding of the internal movement of ricin within cells. However, microscopy techniques are often hampered by complex analysis and quantification techniques, and the inability to look at ricin trafficking in large populations of cells...
November 7, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29100033/inflammation-is-regulated-by-the-adenosine-derivative-molecule-ifc-305-during-reversion-of-cirrhosis-in-a-ccl4-rat-model
#15
Rebeca Pérez-Cabeza de Vaca, Mariana Domínguez-López, Nuria Guerrero-Celis, Jesús R Rodríguez-Aguilera, Victoria Chagoya de Sánchez
Cirrhosis is a liver pathology originated by hepatocytes, Kupffer and hepatic stellate cells interactions and transformations. This pathology is associated with inflammation and fibrosis, originated by molecular signals secreted by immunological and parenchymal cells, such as cytokines and chemokines, like IL-1β, IL-6, TNF-α or MCP-1, driven by Kupffer cells signals. As part of inflammation resolution, the same activated Kupffer cells contribute to anti-inflammatory effects with IL-10 and MMP-9 secretion...
October 28, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29076387/the-efficacy-and-safety-of-transcutaneous-acupoint-interferential-current-stimulation-for-cancer-pain-patients-with-opioid-induced-constipation-a-prospective-randomized-controlled-study
#16
Hua-Dong Zhu, Zhen Gong, Bing-Wei Hu, Qiao-Ling Wei, Jun Kong, Cong-Bin Peng
INTRODUCTION: Opioid-induced constipation (OIC) is a principal complication secondary to analgesic therapy for cancer pain patients who suffer moderate to severe pain. In this study, we observe the efficacy and safety of transcutaneous acupoint interferential current (IFC) stimulation in those patients with OIC. METHODS: A total of 198 patients were randomly allocated to the IFC group and control group in a 1:1 ratio. Finally, 98 patients in the IFC group received 14 sessions administered over 2 weeks, whereas 100 patients in the control group took lactulose orally during the same period...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29076090/analysis-of-erythropoiesis-using-imaging-flow-cytometry
#17
Theodosia Kalfa, Kathleen E McGrath
Erythroid maturation has been classically defined based on the remarkable changes visualized through microscopy. These involve the decrease in cell size, nuclear condensation and organelle loss, and include the final unique asymmetric division creating the short-lived nucleated pyrenocyte and the enucleate reticulocyte that matures into the red blood cell. Understanding the regulation of these processes has been challenging due to the difficulty in obtaining sufficient numbers of cells, particularly of rare intermediates, to study by microscopy...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29059590/quality-assessment-for-wireless-capsule-endoscopy-videos-compressed-via-hevc-from-diagnostic-quality-to-visual-perception
#18
Muhammad Arslan Usman, Muhammad Rehan Usman, Soo Young Shin
Maintaining the quality of medical images and videos is an essential part of the e-services provided by the healthcare sector. The convergence of modern communication systems and the healthcare industry necessitates the provision of better quality of service and experience by the service provider. Recent inclusion and standardization of the high efficiency video coder (HEVC) has made it possible for medical data to be compressed and transmitted over wireless networks with minimal compromise of the quality. Quality evaluation and assessment of these medical videos transmitted over wireless networks is another important research area that requires further exploration and attention...
October 9, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29045599/a-modulatory-effect-of-brief-passive-exposure-to-non-linguistic-sounds-on-intrinsic-functional-connectivity-relevance-to-cognitive-performance
#19
Maki S Koyama, Silvia Ortiz-Mantilla, Cynthia P Roesler, Michael P Milham, April A Benasich
A growing literature on resting-state fMRI (R-fMRI) has explored the impact of preceding sensory experience on intrinsic functional connectivity (iFC). However, it remains largely unknown how passive exposure to irrelevant auditory stimuli, which is a constant in everyday life, reconfigures iFC. Here, we directly compared pre- and post-exposure R-fMRI scans to examine: 1) modulatory effects of brief passive exposure to repeating non-linguistic sounds on subsequent iFC, and 2) associations between iFC modulations and cognitive abilities...
December 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29025070/interdisciplinary-family-conferences-to-improve-patient-experience-in-the-neonatal-intensive-care-unit
#20
Jennifer A Trujillo, Yesenia Fernandez, Lyla Ghafoori, Kristina Lok, Arwin Valencia
Parents play a significant role in the development of their neonate. They can affect the length of stay in a neonatal intensive care unit (NICU) and are seen as an integral part of the team. Parents are often put in positions where difficult decision making is required of them in the care of their critically ill child. Studies suggest that one way to improve the family's experience and to encourage their involvement is by establishing a formal and focused family conference. Therefore, the NICU social workers and the interdisciplinary team collaborated to formulate strategies to improve communication that would enhance current practice...
September 15, 2017: Health & Social Work
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