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https://www.readbyqxmd.com/read/27858126/transcranial-direct-current-stimulation-tdcs-of-the-inferior-frontal-cortex-affects-the-social-scaling-of-extrapersonal-space-depending-on-perspective-taking-ability
#1
Chiara Fini, Lara Bardi, Alessandra Epifanio, Giorgia Committeri, Agnes Moors, Marcel Brass
When we have to judge the distance between another person and an object (social condition), we judge this distance as being smaller compared to judging the distance between two objects (nonsocial condition). It has been suggested that this compression is mediated by the attribution of a motor potential to the reference frame (other person vs. object). In order to explore the neural basis of this effect, we investigated whether the modulation of activity in the inferior frontal cortex (IFC) of the left hemisphere (recruited during visuospatial processes with a social component) changes the way we categorize space in a social compared with a nonsocial condition...
November 17, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27847590/interhemispheric-functional-disconnection-because-of-abnormal-corpus-callosum-integrity-in-bipolar-disorder-type-ii
#2
Fumihiko Yasuno, Takashi Kudo, Kiwamu Matsuoka, Akihide Yamamoto, Masato Takahashi, Jyoji Nakagawara, Kazuyuki Nagatsuka, Hidehiro Iida, Toshifumi Kishimoto
BACKGROUND: A significantly lower fractional anisotropy (FA) value has been shown in anterior parts of the corpus callosum in patients with bipolar disorder. AIMS: We investigated the association between abnormal corpus callosum integrity and interhemispheric functional connectivity (IFC) in patients with bipolar disorder. METHODS: We examined the association between FA values in the corpus callosum (CC-FA) and the IFC between homotopic regions in the anterior cortical structures of bipolar disorder (n=16) and major depressive disorder (n=22) patients with depressed or euthymic states...
November 2016: BJPsych Open
https://www.readbyqxmd.com/read/27832091/impedance-flow-cytometry-a-novel-technique-in-pollen-analysis
#3
Iris Heidmann, Grit Schade-Kampmann, Joep Lambalk, Marcel Ottiger, Marco Di Berardino
INTRODUCTION: An efficient and reliable method to estimate plant cell viability, especially of pollen, is important for plant breeding research and plant production processes. Pollen quality is determined by classical methods, like staining techniques or in vitro pollen germination, each having disadvantages with respect to reliability, analysis speed, and species dependency. Analysing single cells based on their dielectric properties by impedance flow cytometry (IFC) has developed into a common method for cellular characterisation in microbiology and medicine during the last decade...
2016: PloS One
https://www.readbyqxmd.com/read/27825394/shared-atypical-brain-anatomy-and-intrinsic-functional-architecture-in-male-youth-with-autism-spectrum-disorder-and-their-unaffected-brothers
#4
H-Y Lin, W-Y I Tseng, M-C Lai, Y-T Chang, S S-F Gau
BACKGROUND: Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder, yet the search for definite genetic etiologies remains elusive. Delineating ASD endophenotypes can boost the statistical power to identify the genetic etiologies and pathophysiology of ASD. We aimed to test for endophenotypes of neuroanatomy and associated intrinsic functional connectivity (iFC) via contrasting male youth with ASD, their unaffected brothers and typically developing (TD) males...
November 9, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27774057/bayesian-alternation-during-tactile-augmentation
#5
Caspar M Goeke, Serena Planera, Holger Finger, Peter König
A large number of studies suggest that the integration of multisensory signals by humans is well-described by Bayesian principles. However, there are very few reports about cue combination between a native and an augmented sense. In particular, we asked the question whether adult participants are able to integrate an augmented sensory cue with existing native sensory information. Hence for the purpose of this study, we build a tactile augmentation device. Consequently, we compared different hypotheses of how untrained adult participants combine information from a native and an augmented sense...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27771359/is-interferential-current-prior-to-pilates-exercises-more-effective-than-placebo-in-patients-with-chronic-non-specific-low-back-pain-a-randomized-controlled-trial
#6
Katherinne Ferro Moura Franco, Yuri Rafael Dos Santos Franco, Naiane Teixeira Bastos de Oliveira, Gisela Cristiane Miyamoto, Matheus Oliveira Santos, Richard Eloin Liebano, Cristina Maria Nunes Cabral
OBJECTIVE: To determine whether interferential current prior to Pilates exercises is more effective than placebo in patients with chronic non-specific low back pain. DESIGN: Two-arm randomized controlled trial, with blinded assessor, and six months follow-up. SETTING: Clinic of the School of Physical Therapy. PARTICIPANTS: The random sample consisted of 148 patients of both genders, with age between 18 and 80 and chronic non-specific low back pain...
October 19, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27723600/inferring-the-functions-of-proteins-from-the-interrelationships-between-functional-categories
#7
Kamal Taha
This study proposes a new method to determine the functions of an unannotated protein. The proteins and amino acid residues mentioned in biomedical texts associated with an unannotated protein p can be considered as characteristics terms for p, which are highly predictive of the potential functions of p. Similarly, proteins and amino acid residues mentioned in biomedical texts associated with proteins annotated with a functional category f can be considered as characteristics terms of f. We introduce in this paper an information extraction system called IFP_IFC that predicts the functions of an unannotated protein p by representing p and each functional category f by a vector of weights...
October 6, 2016: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/27698649/progressively-disrupted-intrinsic-functional-connectivity-of-basolateral-amygdala-in-very-early-alzheimer-s-disease
#8
Marion Ortner, Lorenzo Pasquini, Martina Barat, Panagiotis Alexopoulos, Timo Grimmer, Stefan Förster, Janine Diehl-Schmid, Alexander Kurz, Hans Förstl, Claus Zimmer, Afra Wohlschläger, Christian Sorg, Henning Peters
Very early Alzheimer's disease (AD) - i.e., AD at stages of mild cognitive impairment (MCI) and mild dementia - is characterized by progressive structural and neuropathologic changes, such as atrophy or tangle deposition in medial temporal lobes, including hippocampus and entorhinal cortex and also adjacent amygdala. While progressively disrupted intrinsic connectivity of hippocampus with other brain areas has been demonstrated by many studies, amygdala connectivity was rarely investigated in AD, notwithstanding its known relevance for emotion processing and mood disturbances, which are both important in early AD...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27665257/cortical-thickness-of-neural-substrates-supporting-cognitive-empathy-in-individuals-with-schizophrenia
#9
Suena H Massey, Daniel Stern, Eva C Alden, Julie E Petersen, Derin J Cobia, Lei Wang, John G Csernansky, Matthew J Smith
BACKGROUND: Cognitive empathy is supported by the medial prefrontal cortex (mPFC), inferior frontal gyrus (IFG), anterior mid-cingulate cortex (aMCC), insula (INS), supplementary motor area (SMA), right temporo-parietal junction (TPJ), and precuneus (PREC). In healthy controls, cortical thickness in these regions has been linked to cognitive empathy. As cognitive empathy is impaired in schizophrenia, we examined whether reduced cortical thickness in these regions was associated with poorer cognitive empathy in this population...
September 21, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27600846/assessing-variations-in-areal-organization-for-the-intrinsic-brain-from-fingerprints-to-reliability
#10
Ting Xu, Alexander Opitz, R Cameron Craddock, Margaret J Wright, Xi-Nian Zuo, Michael P Milham
Resting state fMRI (R-fMRI) is a powerful in-vivo tool for examining the functional architecture of the human brain. Recent studies have demonstrated the ability to characterize transitions between functionally distinct cortical areas through the mapping of gradients in intrinsic functional connectivity (iFC) profiles. To date, this novel approach has primarily been applied to iFC profiles averaged across groups of individuals, or in one case, a single individual scanned multiple times. Here, we used a publically available R-fMRI dataset, in which 30 healthy participants were scanned 10 times (10 min per session), to investigate differences in full-brain transition profiles (i...
September 6, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27594698/an-open-source-solution-for-advanced-imaging-flow-cytometry-data-analysis-using-machine-learning
#11
Holger Hennig, Paul Rees, Thomas Blasi, Lee Kamentsky, Jane Hung, David Dao, Anne E Carpenter, Andrew Filby
Imaging flow cytometry (IFC) enables the high throughput collection of morphological and spatial information from hundreds of thousands of single cells. This high content, information rich image data can in theory resolve important biological differences among complex, often heterogeneous biological samples. However, data analysis is often performed in a highly manual and subjective manner using very limited image analysis techniques in combination with conventional flow cytometry gating strategies. This approach is not scalable to the hundreds of available image-based features per cell and thus makes use of only a fraction of the spatial and morphometric information...
September 1, 2016: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/27587343/differential-morphology-and-transcriptome-profile-between-the-incompletely-fused-carpels-ovary-and-its-wild-type-in-maize
#12
Hongping Li, Yufeng Wu, Yali Zhao, Xiuli Hu, Jianfeng Chang, Qun Wang, Pengfei Dong, Moubiao Zhang, Chaohai Li
We have isolated a new mutation in maize, incompletely fused carpels (ifc), which results in an open stylar canal on the ovary and an incomplete pericarp at the top of the kernel. The maize ovary derives from the fusion of three carpels; however, the molecular networks regulating maize carpel fusion remain largely unclear. In this study, RNA sequencing (RNA-seq) was performed on wild-type (WT) and ifc ovaries that were collected after carpel fusion defects could be morphologically distinguished. In total, 877 differentially expressed genes were identified...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27582125/total-cellular-protein-presence-of-the-transcription-factor-irf8-does-not-necessarily-correlate-with-its-nuclear-presence
#13
Hans Minderman, Orla Maguire, Kieran L O'Loughlin, Jason Muhitch, Paul K Wallace, Scott I Abrams
The transcription factor interferon regulatory factor-8 (IRF8) plays an essential role in myeloid differentiation and lineage commitment, based largely on molecular and genetic studies. The detection of IRF8 in specific cell populations by flow cytometry (FCM) has the potential to provide new insights into normal and pathologic myelopoiesis, but critical validation of this protein-based approach, particularly in human samples, is lacking. In this study, the assessment of total cellular IRF8 presence was compared to its specific nuclear presence as assessed by imaging flow cytometry (IFC) analysis...
August 28, 2016: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/27582124/delineating-stages-of-erythropoiesis-using-imaging-flow-cytometry
#14
K E McGrath, S C Catherman, J Palis
Adult humans need to make 2.5million red blood cells (RBCs) every second to maintain a steady state level of 25trillion circulating RBCs. Understanding normal erythropoiesis as well as diseases that afflict the erythron, such as genetic anemias, hyperproliferative disorders, and myelodysplastic syndromes, requires a robust method to delineate erythropoietic intermediates. In order to apply the power of flow cytometry to these studies, challenges of limited immunophenotypic markers, incorporation of significant changes in morphology, and maturational changes that occur along a continuum need to be met...
August 28, 2016: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/27542783/culprit-plaque-morphology-in-stemi-an-optical-coherence-tomography-study-insights-from-the-total-oct-substudy
#15
Olli A Kajander, Natalia Pinilla-Echeverri, Sanjit S Jolly, Ravinay Bhindi, Heini Huhtala, Kari Niemelä, Anthony Fung, Ram Vijayaraghavan, Dimitrios Alexopoulos, Tej Sheth
AIMS: Our aim was to compare stenosis severity and plaque content between STEMI culprit lesions with intact fibrous cap (IFC) and those with plaque rupture (PR) in a prospective study. METHODS AND RESULTS: We evaluated 93 patients undergoing OCT and thrombectomy as part of a prospective substudy of the TOTAL (ThrOmbecTomy versus PCI ALone) trial. Culprit lesion morphology was assessable by OCT in 70/93 (75.3%). IFC was found in 31 (44.3%), PR in 34 (48.6%) and calcified nodule in five (7...
August 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27524557/foundations-of-identifying-individual-chromosomes-by-imaging-flow-cytometry-with-applications-in-radiation-biodosimetry
#16
Lindsay A Beaton-Green, Matthew A Rodrigues, Sylvie Lachapelle, Ruth C Wilkins
Biodosimetry is an important tool for triage in the case of large-scale radiological or nuclear emergencies, but traditional microscope-based methods can be tedious and prone to scorer fatigue. While the dicentric chromosome assay (DCA) has been adapted for use in triage situations, it is still time-consuming to create and score slides. Recent adaptations of traditional biodosimetry assays to imaging flow cytometry (IFC) methods have dramatically increased throughput. Additionally, recent improvements in image analysis algorithms in IFC software have resulted in improved specificity for spot counting of small events...
August 11, 2016: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/27493984/the-effectiveness-and-safety-of-a-homeopathic-medicinal-product-in-pediatric-upper-respiratory-tract-infections-with-fever-a-randomized-controlled-trial
#17
Robert van Haselen, Manuela Thinesse-Mallwitz, Vitaliy Maidannyk, Stephen L Buskin, Stephan Weber, Thomas Keller, Julia Burkart, Petra Klement
We investigated the clinical effectiveness of a homeopathic add-on therapy in a pediatric subpopulation with upper respiratory tract infections (URTI) in a randomized, controlled, multinational clinical trial. Patients received either on-demand symptomatic standard treatment (ST-group) or the same ST plus a homeopathic medication (Influcid; IFC-group) for 7 days. Outcome assessment was based on symptom and fever resolution and the Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21). A total of 261 pediatric (<12 years) patients (130 IFC-group; 131 ST-group) were recruited in Germany and the Ukraine...
2016: Global Pediatric Health
https://www.readbyqxmd.com/read/27484800/ligand-induced-epitope-masking-dissociation-of-integrin-%C3%AE-5%C3%AE-1-fibronectin-complexes-only-by-monoclonal-antibodies-with-an-allosteric-mode-of-action
#18
A Paul Mould, Janet A Askari, Adam Byron, Yoshikazu Takada, Thomas A Jowitt, Martin J Humphries
We previously demonstrated that Arg-Gly-Asp (RGD)-containing ligand-mimetic inhibitors of integrins are unable to dissociate pre-formed integrin-fibronectin complexes (IFCs). These observations suggested that amino acid residues involved in integrin-fibronectin binding become obscured in the ligand-occupied state. Because the epitopes of some function-blocking anti-integrin monoclonal antibodies (mAbs) lie near the ligand-binding pocket, it follows that the epitopes of these mAbs may become shielded in the ligand-occupied state...
September 30, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27460240/fluorescent-in-situ-hybridization-in-suspension-by-imaging-flow-cytometry
#19
Orla Maguire, Paul K Wallace, Hans Minderman
The emergence of imaging flow cytometry (IFC) has brought novel applications exploiting its advantages over conventional flow cytometry and microscopy. One of the new applications is fluorescence in situ hybridization in suspension (FISH-IS). Conventional FISH is a slide-based approach in which the spotlike imagery resulting from hybridization with fluorescently tagged probes is evaluated by fluorescence microscopy. The FISH-IS approach evaluated by IFC enables the evaluation of tens to hundreds of thousands of cells in suspension and the analysis can be automated and standardized diminishing operator bias from the analysis...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27460238/the-analysis-of-cell-cycle-proliferation-and-asymmetric-cell-division-by-imaging-flow-cytometry
#20
Andrew Filby, William Day, Sukhveer Purewal, Nuria Martinez-Martin
Measuring cellular DNA content by conventional flow cytometry (CFC) and fluorescent DNA-binding dyes is a highly robust method for analysing cell cycle distributions within heterogeneous populations. However, any conclusions drawn from single-parameter DNA analysis alone can often be confounded by the asynchronous nature of cell proliferation. We have shown that by combining fluorescent DNA stains with proliferation tracking dyes and antigenic staining for mitotic cells one can elucidate the division history and cell cycle position of any cell within an asynchronously dividing population...
2016: Methods in Molecular Biology
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