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https://www.readbyqxmd.com/read/28209723/functional-metabolic-and-dynamic-mitochondrial-changes-in-the-rat-cirrhosis-hepatocellular-carcinoma-model-and-the-protective-effect-of-ifc-305
#1
Enrique Chavez, Maria Guadalupe Lozano-Rosas, Mariana Dominguez-Lopez, Gabriela Velasco-Loyden, Jesus Rafael Rodriguez-Aguilera, Concepcion Jose-Nunez, Marietta Tuena de Gomez-Puyou, Victoria Chagoya de Sanchez
BACKGROUND: Mitochondrion is an important metabolic and energetic organelle which regulates several cellular processes. Mitochondrial dysfunction has been related with liver diseases including hepatocellular carcinoma. As a result, the energetic demand is not properly supplied and mitochondrial morphologic changes has been observed resulting in an altered metabolism. We previously demonstrated the chemopreventive effect of the hepatoprotector IFC-305. AIM: In this work we aimed to evaluate the functional, metabolic, and dynamic mitochondrial alterations in the sequential model of cirrhosis-hepatocellular carcinoma induced by diethylnitrosamine in rats and the possible beneficial effect of IFC-305...
February 16, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28195438/from-rest-to-language-task-task-activation-selects-and-prunes-from-broader-resting-state-network
#2
Gaelle E Doucet, Xiaosong He, Michael R Sperling, Ashwini Sharan, Joseph I Tracy
Resting-state networks (RSNs) show spatial patterns generally consistent with networks revealed during cognitive tasks. However, the exact degree of overlap between these networks has not been clearly quantified. Such an investigation shows promise for decoding altered functional connectivity (FC) related to abnormal language functioning in clinical populations such as temporal lobe epilepsy (TLE). In this context, we investigated the network configurations during a language task and during resting state using FC...
February 14, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28169142/the-american-college-of-radiology-incidental-findings-committee-recommendations-for-management-of-incidental-lymph-nodes-a-single-center-evaluation
#3
Paul Smereka, Ankur M Doshi, Justin M Ream, Andrew B Rosenkrantz
RATIONALE AND OBJECTIVES: To assess the American College of Radiology Incidental Findings Committee's (ACR-IFC) recommendations for defining and following up abnormal incidental abdominopelvic lymph nodes. MATERIALS AND METHODS: A total of 59 lymph nodes satisfying ACR-IFC criteria as incidental (no malignancy or lymphoproliferative disorder) and with sufficient follow-up to classify as benign (biopsy, decreased size, ≥12-month stability) or malignant (biopsy, detection of primary malignancy combined with either fluorodeoxyglucose hyperactivity or increase in size of the node) were included...
February 3, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28167957/histological-and-immunohistochemical-evaluation-of-the-efficacy-of-a-new-cosmetic-formulation-in-the-treatment-of-skin-photoaging
#4
M T Truchuelo, N Jiménez, L Miguel-Gomez, A Hermosa, N Sánchez-Neila, J Cuevas
Objective. Mechanism of action of cosmetic products is not often studied. The aim of this study is to determine the histological, immunohistochemical, and clinical changes of a new cosmetic formulation. Methods. Prospective, single-blind, patient-controlled, randomized study in 10 volunteers with mild to moderate skin photoaging on the back of their hands. The product was applied on one hand and a standard cream on the other hand, twice a day for three months. Standardized photographs were taken on basal (T0) and final visit (T1) and skin biopsies were performed...
2017: Dermatology Research and Practice
https://www.readbyqxmd.com/read/28160085/transcutaneous-electrical-nerve-stimulation-reduces-exercise-induced-perceived-pain-and-improves-endurance-exercise-performance
#5
Ali H Y Astokorki, Alexis R Mauger
PURPOSE: Muscle pain is a natural consequence of intense and prolonged exercise and has been suggested to be a limiter of performance. Transcutaneous electrical nerve stimulation (TENS) and interferential current (IFC) have been shown to reduce both chronic and acute pain in a variety of conditions. This study sought to ascertain whether TENS and IFC could reduce exercise-induced pain (EIP) and whether this would affect exercise performance. It was hypothesised that TENS and IFC would reduce EIP and result in an improved exercise performance...
February 3, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28135347/comparing-sensitivity-estimates-from-mlds-and-forced-choice-methods-in-a-slant-from-texture-experiment
#6
Guillermo Aguilar, Felix A Wichmann, Marianne Maertens
Maximum likelihood difference scaling (MLDS) is a method for the estimation of perceptual scales based on the judgment of differences in stimulus appearance (Maloney & Yang, 2003). MLDS has recently also been used to estimate near-threshold discrimination performance (Devinck & Knoblauch, 2012). Using MLDS as a psychophysical method for sensitivity estimation is potentially appealing, because MLDS has been reported to need less data than forced-choice procedures, and particularly naive observers report to prefer suprathreshold comparisons to JND-style threshold tasks...
January 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28128700/biomechanical-evaluation-of-an-integrated-fixation-cage-during-fatigue-loading-a-human-cadaver-study
#7
Vivek Palepu, Jonathan H Peck, David D Simon, Melvin D Helgeson, Srinidhi Nagaraja
OBJECTIVE Lumbar cages with integrated fixation screws offer a low-profile alternative to a standard cage with anterior supplemental fixation. However, the mechanical stability of integrated fixation cages (IFCs) compared with a cage with anterior plate fixation under fatigue loading has not been investigated. The purpose of this study was to compare the biomechanical stability of a screw-based IFC with a standard cage coupled with that of an anterior plate under fatigue loading. METHODS Eighteen functional spinal units were implanted with either a 4-screw IFC or an anterior plate and cage (AP+C) without integrated fixation...
January 27, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28122025/intrinsic-functional-connectivity-alterations-of-the-primary-visual-cortex-in-primary-angle-closure-glaucoma-patients-before-and-after-surgery-a-resting-state-fmri-study
#8
Shenghong Li, Ping Li, Honghan Gong, Fei Jiang, Dan Liu, Fengqin Cai, Chonggang Pei, Fuqing Zhou, Xianjun Zeng
PURPOSE: To investigate the altered intrinsic functional connectivity (iFC) of the primary visual cortex (V1) in primary angle-closure glaucoma (PACG) patients before and after surgery using resting-state functional MRI. MATERIALS AND METHODS: Twenty-five preoperative PACG (pre-PACG) patients and 25 well-matched healthy controls (HCs) were included in this study, and 9 PACG patients were assessed again at least 3 months after treatment (post-PACG). We generated the iFC maps of the seed regions in the centers of the left and right V1 and conducted group comparisons...
2017: PloS One
https://www.readbyqxmd.com/read/28113105/reorganization-of-brain-function-after-a-short-term-behavioral-intervention-for-stuttering
#9
Chunming Lu, Lifen Zheng, Yuhang Long, Qian Yan, Guosheng Ding, Li Liu, Danling Peng, Peter Howell
This study investigated changes in brain function that occurred over a 7-day behavioral intervention for adults who stutter (AWS). Thirteen AWS received the intervention (AWS+), and 13 AWS did not receive the intervention (AWS-). There were 13 fluent controls (FC-). All participants were scanned before and after the intervention. Whole-brain analysis pre-intervention showed significant differences in task-related brain activation between AWS and FC- in the right inferior frontal cortex (IFC) and left middle temporal cortex, but there were no differences between the two AWS groups...
January 20, 2017: Brain and Language
https://www.readbyqxmd.com/read/28079926/fallen-stock-data-an-essential-source-of-information-for-quantitative-knowledge-of-equine-mortality-in-france
#10
J Tapprest, E Morignat, X Dornier, M Borey, P Hendrikx, B Ferry, D Calavas, C Sala
BACKGROUND: Quantitative information about equine mortality is relatively scarce, yet it could be of great value for epidemiological purposes. In France, data from rendering plants are centralised in the Fallen Stock Data Interchange database (FSDI), managed by the French Ministry of Agriculture, while individual equine data are centralised in the French equine census database, SIRE, managed by the French horse and riding institute (IFCE). OBJECTIVES: To evaluate whether the combined use of the FSDI and the SIRE databases can provide representative and accurate quantitative information on mortality for the French equine population, and to propose enhancements of these databases to improve the quality of the resulting demographic information...
January 12, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28032201/intrinsic-functional-connectivity-of-fronto-temporal-networks-in-adolescents-with-early-psychosis
#11
Cristina Solé-Padullés, Josefina Castro-Fornieles, Elena de la Serna, Vanessa Sánchez-Gistau, Soledad Romero, Olga Puig, Anna Calvo, Nuria Bargalló, Inmaculada Baeza, Gisela Sugranyes
Adults with psychotic disorders have abnormal connectivity of fronto-temporal networks. However, whether these abnormalities are present in adolescents with early psychosis has not been fully assessed. One-hundred and thirty-nine adolescents aged 12-18 underwent resting-state functional magnetic resonance imaging and diffusion tensor imaging. Following motion correction, data were available for 44 participants with a psychosis risk syndrome, 34 patients with a first episode psychosis (FEP) and 35 healthy controls...
December 28, 2016: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/27995073/distinct-effects-of-childhood-adhd-and-cannabis-use-on-brain-functional-architecture-in-young-adults
#12
Clare Kelly, F Xavier Castellanos, Olivia Tomaselli, Krista Lisdahl, Leanne Tamm, Terry Jernigan, Erik Newman, Jeffery N Epstein, Brooke S G Molina, Laurence L Greenhill, Steven G Potkin, Stephen Hinshaw, James M Swanson
One of the most salient long-term implications of a childhood diagnosis of ADHD is an increased risk for substance use, abuse, or dependence in adolescence and adulthood. The extent to which cannabis use affects ADHD-related alterations in brain functional organization is unknown, however. To address this research gap, we recruited a sample of 75 individuals aged 21-25 years with and without a childhood diagnosis of ADHD Combined Type, who were either frequent users or non-users of cannabis. These participants have been followed longitudinally since age 7-9...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27990494/relationships-between-altered-functional-magnetic-resonance-imaging-activation-and-cortical-thickness-in-patients-with-euthymic-bipolar-i-disorder
#13
Shantanu H Joshi, Nathalie Vizueta, Lara Foland-Ross, Jennifer D Townsend, Susan Y Bookheimer, Paul M Thompson, Katherine L Narr, Lori L Altshuler
BACKGROUND: Performance during cognitive control functional magnetic resonance imaging (fMRI) tasks are associated with frontal lobe hypoactivation in patients with bipolar disorder, even while euthymic. Here, we study the structural underpinnings for this functional abnormality simultaneously with brain activation data. METHODS: In a sample of ninety adults (45 with inter-episode Bipolar I disorder and 45 healthy controls), we explored whether abnormal functional activation patterns in bipolar euthymic subjects during a Go-NoGo fMRI task are associated with regional deficits in cortical gray matter thickness in the same regions...
November 2016: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/27983797/high-performance-ratiometric-electrochemical-method-based-on-the-combination-of-signal-probe-and-inner-reference-probe-in-one-hairpin-structured-dna
#14
Chunyan Deng, Xiaomei Pi, Pin Qian, Xiaoqing Chen, Wuming Wu, Juan Xiang
In this work, the dual signal-tagged hairpin structured DNA (dhDNA)-based ratiometric probe was developed by the combination of ferrocene-labeled signal probe (Fc-sP) and methylene blue-modified inner reference probe (MB-rP) in one hairpin-structured DNA. On the basis of this, a high-performance ratiometric electrochemical method was proposed for biomarker detection. In contrast to the conventional ratiometric electrochemical probe, this dhDNA ratiometric probe integrated sP and rP into one structure, which ensured the completely same modification condition and the interdependence of sP and rP on one sensing interface...
December 16, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27858126/transcranial-direct-current-stimulation-tdcs-of-the-inferior-frontal-cortex-affects-the-social-scaling-of-extrapersonal-space-depending-on-perspective-taking-ability
#15
Chiara Fini, Lara Bardi, Alessandra Epifanio, Giorgia Committeri, Agnes Moors, Marcel Brass
When we have to judge the distance between another person and an object (social condition), we judge this distance as being smaller compared to judging the distance between two objects (nonsocial condition). It has been suggested that this compression is mediated by the attribution of a motor potential to the reference frame (other person vs. object). In order to explore the neural basis of this effect, we investigated whether the modulation of activity in the inferior frontal cortex (IFC) of the left hemisphere (recruited during visuospatial processes with a social component) changes the way we categorize space in a social compared with a nonsocial condition...
November 17, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27847590/interhemispheric-functional-disconnection-because-of-abnormal-corpus-callosum-integrity-in-bipolar-disorder-type-ii
#16
Fumihiko Yasuno, Takashi Kudo, Kiwamu Matsuoka, Akihide Yamamoto, Masato Takahashi, Jyoji Nakagawara, Kazuyuki Nagatsuka, Hidehiro Iida, Toshifumi Kishimoto
BACKGROUND: A significantly lower fractional anisotropy (FA) value has been shown in anterior parts of the corpus callosum in patients with bipolar disorder. AIMS: We investigated the association between abnormal corpus callosum integrity and interhemispheric functional connectivity (IFC) in patients with bipolar disorder. METHODS: We examined the association between FA values in the corpus callosum (CC-FA) and the IFC between homotopic regions in the anterior cortical structures of bipolar disorder (n=16) and major depressive disorder (n=22) patients with depressed or euthymic states...
November 2016: BJPsych Open
https://www.readbyqxmd.com/read/27832091/impedance-flow-cytometry-a-novel-technique-in-pollen-analysis
#17
Iris Heidmann, Grit Schade-Kampmann, Joep Lambalk, Marcel Ottiger, Marco Di Berardino
INTRODUCTION: An efficient and reliable method to estimate plant cell viability, especially of pollen, is important for plant breeding research and plant production processes. Pollen quality is determined by classical methods, like staining techniques or in vitro pollen germination, each having disadvantages with respect to reliability, analysis speed, and species dependency. Analysing single cells based on their dielectric properties by impedance flow cytometry (IFC) has developed into a common method for cellular characterisation in microbiology and medicine during the last decade...
2016: PloS One
https://www.readbyqxmd.com/read/27825394/shared-atypical-brain-anatomy-and-intrinsic-functional-architecture-in-male-youth-with-autism-spectrum-disorder-and-their-unaffected-brothers
#18
H-Y Lin, W-Y I Tseng, M-C Lai, Y-T Chang, S S-F Gau
BACKGROUND: Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder, yet the search for definite genetic etiologies remains elusive. Delineating ASD endophenotypes can boost the statistical power to identify the genetic etiologies and pathophysiology of ASD. We aimed to test for endophenotypes of neuroanatomy and associated intrinsic functional connectivity (iFC) via contrasting male youth with ASD, their unaffected brothers and typically developing (TD) males...
November 9, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27774057/bayesian-alternation-during-tactile-augmentation
#19
Caspar M Goeke, Serena Planera, Holger Finger, Peter König
A large number of studies suggest that the integration of multisensory signals by humans is well-described by Bayesian principles. However, there are very few reports about cue combination between a native and an augmented sense. In particular, we asked the question whether adult participants are able to integrate an augmented sensory cue with existing native sensory information. Hence for the purpose of this study, we build a tactile augmentation device. Consequently, we compared different hypotheses of how untrained adult participants combine information from a native and an augmented sense...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27771359/is-interferential-current-before-pilates-exercises-more-effective-than-placebo-in-patients-with-chronic-nonspecific-low-back-pain-a-randomized-controlled-trial
#20
Katherinne Moura Franco, Yuri Dos Santos Franco, Naiane Bastos de Oliveira, Gisela Cristiane Miyamoto, Matheus Oliveira Santos, Richard Eloin Liebano, Cristina Nunes Cabral
OBJECTIVE: To determine whether interferential current (IFC) before Pilates exercises is more effective than placebo in patients with chronic nonspecific low back pain. DESIGN: Two-arm randomized controlled trial, with a blinded assessor, and 6 months follow-up. SETTING: Clinic of a school of physical therapy. PARTICIPANTS: The random sample consisted of patients (N=148) of both sexes, with age between 18 and 80 years and chronic nonspecific low back pain...
February 2017: Archives of Physical Medicine and Rehabilitation
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