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https://www.readbyqxmd.com/read/29904344/altered-brain-regional-homogeneity-following-electro-acupuncture-stimulation-at-sanyinjiao-sp6-in-women-with-premenstrual-syndrome
#1
Yong Pang, Huimei Liu, Gaoxiong Duan, Hai Liao, Yanfei Liu, Zhuo Feng, Jien Tao, Zhuocheng Zou, Guoxiang Du, Rongchao Wan, Peng Liu, Demao Deng
Background : Premenstrual syndrome (PMS) is a menstrual cycle-related disorder which causes physical and mood changes prior to menstruation and is associated with the functional dysregulation of the brain. Acupuncture is an effective alternative therapy for treating PMS, and sanyinjiao (SP6) is one of the most common acupoints used for improving the symptoms of PMS. However, the mechanism behind acupuncture's efficacy for relieving PMS symptoms remains unclear. The aim of this study was to identify the brain response patterns induced by acupuncture at acupoint SP6 in patients with PMS...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29899404/cortico-thalamic-hypo-and-hyperconnectivity-extend-consistently-to-basal-ganglia-in-schizophrenia
#2
Mihai Avram, Felix Brandl, Josef Bäuml, Christian Sorg
Schizophrenia is characterized by hypoconnectivity or decreased intrinsic functional connectivity (iFC) between prefrontal-limbic cortices and thalamic nuclei, as well as hyperconnectivity or increased iFC between primary-sensorimotor cortices and thalamic nuclei. However, cortico-thalamic iFC overlaps with larger, structurally defined cortico-striato-pallido-thalamo-cortical (CSPTC) circuits. If such an overlap is relevant for intrinsic hypo-/hyperconnectivity, it suggests (i) that patterns of cortico-subcortical hypo-/hyperconnectivity extend consistently from thalamus to basal ganglia nuclei; and (ii) such consistent hypo-/hyperconnectivity might link distinctively but consonant with different symptom dimensions, namely cognitive and psychotic impairments...
April 12, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29890309/genetic-variants-in-the-promoter-region-of-the-klf3-gene-associated-with-fat-deposition-in-qinchuan-cattle
#3
Hongfang Guo, Sayed Haidar Abbas Raza, Nicola M Schreurs, Rajwali Khan, Dawei Wei, Li Wang, Song Zhang, Le Zhang, Sen Wu, Irfan Ullah, Seyed Mahdi Hosseini, Linsen Zan
Krüppel-like factor 3 (KLF3), a member of the Krüppel-like factor (KLF) family, plays an important role in adipogenesis and lipid metabolism. The aim of this study was to investigate whether KLF3 could be used as a candidate gene in the breeding of cattle. The expression pattern of bovine KLF3 gene revealed that it was highly expressed in abdominal fat and perirenal fat. Using DNA sequencing, three single nucleotide polymorphisms (SNPs) within the promoter regions of KLF3 gene were identified in 448 Qinchuan cattle, which are located in the recognition sequences of 11 transcription factors and the four haplotypes representing four potential different compositions of polymorphic potential cis-acting elements...
June 8, 2018: Gene
https://www.readbyqxmd.com/read/29881375/monitoring-extracellular-vesicle-cargo-active-uptake-by-imaging-flow-cytometry
#4
Yifat Ofir-Birin, Paula Abou Karam, Ariel Rudik, Tal Giladi, Ziv Porat, Neta Regev-Rudzki
Extracellular vesicles are essential for long distance cell-cell communication. They function as carriers of different compounds, including proteins, lipids and nucleic acids. Pathogens, like malaria parasites ( Plasmodium falciparum, Pf ), excel in employing vesicle release to mediate cell communication in diverse processes, particularly in manipulating the host response. Establishing research tools to study the interface between pathogen-derived vesicles and their host recipient cells will greatly benefit the scientific community...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29878280/schizotypal-traits-are-linked-to-dopamine-induced-striato-cortical-decoupling-a-randomized-double-blind-placebo-controlled-study
#5
Julian Rössler, Lui Unterassner, Thomas Wyss, Helene Haker, Peter Brugger, Wulf Rössler, Diana Wotruba
The dopamine hypothesis of schizophrenia implies that alterations in the dopamine system cause functional abnormalities in the brain that may converge to aberrant salience attribution and eventually lead to psychosis. Indeed, widespread brain disconnectivity across the psychotic spectrum has been revealed by resting-state functional magnetic resonance imaging (rs-fMRI). However, the dopaminergic involvement in intrinsic functional connectivity (iFC) and its putative relationship to the development of psychotic spectrum disorders remains partly unclear-in particular at the low-end of the psychosis continuum...
June 7, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29847980/denying-humanity-the-distinct-neural-correlates-of-blatant-dehumanization
#6
Emile Bruneau, Nir Jacoby, Nour Kteily, Rebecca Saxe
Recent behavioral work demonstrates that many people view low-status groups as less "evolved and civilized" than high-status groups. Are these people using blatant expressions of dehumanization simply to express strong dislike toward other groups? Or is blatant dehumanization a process distinct from other negative assessments? We tested these competing hypotheses using functional neuroimaging. Participants judged 10 groups (e.g., Europeans, Muslims, rats) on four scales: blatant dehumanization, dislike, dissimilarity and perceived within-group homogeneity...
May 31, 2018: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/29787547/interrupted-versus-continuous-fascial-closure-in-patients-undergoing-emergent-laparotomy-a-randomized-controlled-trial
#7
Thomas Peponis, Jordan D Bohnen, Sandra Muse, Eva Fuentes, Gwendolyn M van der Wilden, Ali Mejaddam, Hasan Alam, Haytham M A Kaafarani, Peter J Fagenholz, David R King, D Dante Yeh, George C Velmahos, Marc A de Moya
BACKGROUND: The optimal method of fascial closure, interrupted versus continuous (IFC and CFC respectively) has never been studied exclusively in the setting of emergency surgery. We hypothesized that IFC decreases postoperative incisional hernia development following emergent laparotomies. METHODS: Between August 2008 and September 2015, patients undergoing emergent laparotomies were consented and randomly assigned to either IFC or CFC. Patients were followed postoperatively for at least three months and assessed for incisional hernia, dehiscence, or wound infection...
May 4, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29772013/rapid-differentiation-of-epithelial-cell-types-in-aged-biological-samples-using-autofluorescence-and-morphological-signatures
#8
Emily R Brocato, M Katherine Philpott, Catherine C Connon, Christopher J Ehrhardt
Establishing the tissue source of epithelial cells within a biological sample is an important capability for forensic laboratories. In this study we used Imaging Flow Cytometry (IFC) to analyze individual cells recovered from buccal, epidermal, and vaginal samples that had been dried between 24 hours and more than eight weeks. Measurements capturing the size, shape, and fluorescent properties of cells were collected in an automated manner and then used to build a multivariate statistical framework for differentiating cells based on tissue type...
2018: PloS One
https://www.readbyqxmd.com/read/29767364/single-cell-mrna-seq-using-the-fluidigm-c1-system-and-integrated-fluidics-circuits
#9
Haibiao Gong, Devin Do, Ramesh Ramakrishnan
Single-cell mRNA-seq is a valuable tool to dissect expression profiles and to understand the regulatory network of genes. Microfluidics is well suited for single-cell analysis owing both to the small volume of the reaction chambers and easiness of automation. Here we describe the workflow of single-cell mRNA-seq using C1 IFC, which can isolate and process up to 96 cells. Both on-chip procedure (lysis, reverse transcription, and preamplification PCR) and off-chip sequencing library preparation protocols are described...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29724490/cortical-paired-associative-stimulation-influences-response-inhibition-cortico-cortical-and-cortico-subcortical-networks
#10
Sina Kohl, Ricci Hannah, Lorenzo Rocchi, Camilla L Nord, John Rothwell, Valerie Voon
BACKGROUND: The ability to stop a suboptimal response is integral to decision making and is commonly impaired across psychiatric disorders. Cortical paired associative stimulation (cPAS) is a form of transcranial magnetic stimulation in which paired pulses can induce plasticity at cortical synapses. Here we used cPAS protocols to target cortico-cortical and cortico-subcortical networks by using different intervals between the paired pulses in an attempt to modify response inhibition. METHODS: A total of 25 healthy volunteers underwent four cPAS sessions in random order 1 week apart: right inferior frontal cortex (IFC) stimulation preceding right presupplementary motor area (pre-SMA) stimulation by 10 or 4 ms and pre-SMA stimulation preceding IFC stimulation by 10 or 4 ms...
April 3, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29722602/low-level-laser-therapy-and-interferential-current-in-patients-with-knee-osteoarthritis-a-randomized-controlled-trial-protocol
#11
Renata Alqualo-Costa, Gustavo R Thomé, Mônica R Perracini, Richard E Liebano
The aim of this study is to investigate the effects of low-level laser therapy and interferential current (IFC) on pain intensity, central sensitization, muscle strength and functional capacity in patients with knee osteoarthritis. Participants will be patients aged between 50 and 80 years, with knee osteoarthritis, pain intensity ranging from 3 to 8 points (0-10 scale), Lequesne Algofunctional Index ranging from 5 to 15 points, and Kellgren & Lawrence grade ≥2. A total of 168 patients will be randomly allocated into four groups as follows: active IFC + laser sham (G1), IFC sham + active laser (G2), active IFC + laser (G3) and IFC + laser sham (G4)...
May 3, 2018: Pain Management
https://www.readbyqxmd.com/read/29691715/influence-of-sewage-sludge-as-a-substrate-in-the-plasticity-of-functional-characteristics-of-plants
#12
Vicente Elício Porfiro Sales Gonçalves da Silva, Patrícia Marques Carneiro Buarque, Wanessa Nepomuceno Ferreira, Hugo Leonardo de Brito Buarque, Maria Amanda Menezes Silva
This work aimed to evaluate the effect of sewage sludge application as fertilizer on the plasticity of functional characteristics of species commonly found in the Caatinga. The research was developed in the nursery of the Federal Institute of Education, Science and Technology of Ceará (IFCE), Quixadá campus, located in northeastern Brazil. Three treatments were applied: raw sludge, sanitized sludge, and no manipulation. In each treatment, five species were planted, each with five individuals, totaling 75 individuals, which were tagged, and 4 months after germination, they were destroyed to obtain dry matter content (TMSF) from leaf, stem (TMSC), fine root (TMSRF), and thick root (TMSRG); leaf area; height and diameter of the seedling; and length above and below the ground...
April 24, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29688347/yaam-yeast-amino-acid-modifications-database
#13
Leonardo Ledesma, Eduardo Sandoval, Uriel Cruz-Martínez, Ana María Escalante, Selene Mejía, Paola Moreno-Álvarez, Emiliano Ávila, Erik García, Gerardo Coello, Francisco Torres-Quiroz
http://yaam.ifc.unam.mx/.
January 1, 2018: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29685078/prelabour-myocardial-deformation-and-cardiac-output-in-fetuses-that-develop-intrapartum-compromise-at-term-a-prospective-observational-study
#14
Amal A Alsolai, Larissa N Bligh, Ristan M Greer, Alexander Gooi, Sailesh Kumar
OBJECTIVE: Redistribution of cardiac output is responsible for the "brain sparing" effect seen during periods of acute or chronic fetal stress. We investigated the relationship between prelabour cardiac function in fetuses that subsequently developed intrapartum fetal compromise (IFC). METHODS: A blinded, prospective, observational, cohort study, at Mater Mother's Hospital, Brisbane, Australia. A cohort of 284 women with uncomplicated singleton pregnancies underwent ultrasound every 2 weeks from 36 weeks until delivery...
May 9, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29671156/alteration-and-role-of-interhemispheric-and-intrahemispheric-connectivity-in-motor-network-after-stroke
#15
Jungsoo Lee, Eunhee Park, Ahee Lee, Won Hyuk Chang, Dae-Shik Kim, Yun-Hee Kim
This study investigated local and global changes in the motor network using longitudinal resting-state functional magnetic resonance imaging (rs-fMRI). Motor impairment was measured in 81 stroke patients using Fugl-Meyer assessment on the same day as rs-fMRI acquisition at both 2 weeks and 3 months post-stroke. The relationships between network measures and motor function scores were assessed. With regard to local connectivity, interhemispheric connectivity was noticeably altered at each time point. Interhemispheric connectivity was also related to residual motor function and improvement in motor function...
April 18, 2018: Brain Topography
https://www.readbyqxmd.com/read/29652778/does-the-use-of-electrotherapies-increase-the-effectiveness-of-neck-stabilization-exercises-for-improving-pain-disability-mood-and-quality-of-life-in-chronic-neck-pain-a-randomized-controlled-single-blind-study
#16
Hilal Yesil, Simin Hepguler, Umit Dundar, Sahel Taravati, Banu Isleten
STUDY DESIGN: This study was a prospective, randomized, controlled study. OBJECTIVE: The aim of this study was to determine if transcutaneous electrical nerve stimulation (TENS) or interferential current (IFC) increase the effectiveness of neck stabilization exercises on pain, disability, mood, and quality of life for chronic neck pain (CNP). SUMMARY OF BACKGROUND DATA: Neck pain is one of the three most frequently reported complaints of the musculoskeletal system...
April 12, 2018: Spine
https://www.readbyqxmd.com/read/29618055/malignancy-index-using-intraoperative-flow-cytometry-is-a-valuable-prognostic-factor-for-glioblastoma-treated-with-radiotherapy-and-concomitant-temozolomide
#17
Taiichi Saito, Yoshihiro Muragaki, Takahiro Shioyama, Takashi Komori, Takashi Maruyama, Masayuki Nitta, Takayuki Yasuda, Junji Hosono, Saori Okamoto, Takakazu Kawamata
BACKGROUND: Intraoperative prediction of radiochemosensitivity is desirable for improving the clinical management of glioblastoma (GBM) patients. We have previously developed an original technique for intraoperative flow cytometry (iFC) and defined a malignancy index (MI). OBJECTIVE: To determine whether MI correlates with prognosis in GBM patients who underwent the standard treatment protocol of radiotherapy and temozolomide administration. METHODS: The current study included 102 patients with GBM that had been newly diagnosed from 2010 to 2015 who underwent our iFC analysis and received the standard treatment protocol...
March 30, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29606995/double-blind-placebo-controlled-trial-to-evaluate-the-effectiveness-of-polypodium-leucotomos-extract-in-the-treatment-of-melasma-in-asian-skin-a-pilot-study
#18
Chee-Leok Goh, Sai Yee Chuah, Steven Tien, Guan Thng, María Alejandra Vitale, Arancha Delgado-Rubin
Introduction: Melasma is a common pigmentary disorder with a multifactorial etiology that can hinder its management. The aqueous extract of the fern Polypodium leucotomos (PLE), Fernblock® (IFC, Madrid, Spain), has demonstrated antioxidant and photoprotective activities and has been used for the treatment of several pigmentary disorders. The aim of this study was to evaluate the efficacy and safety of oral PLE in the treatment of melasma in Asian patients. Methods: Forty healthy adult patients with clinical diagnoses of melasma who were receiving treatment with topical 4% hydroquinone cream and sunscreen with a sun protection factor (SPF) of 50+ were recruited for inclusion in this study from the National Skin Centre in Singapore...
March 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29602783/quantitative-imaging-flow-cytometry-of-legionella-infected-dictyostelium-amoebae-reveals-the-impact-of-retrograde-trafficking-on-pathogen-vacuole-composition
#19
Amanda Welin, Stephen Weber, Hubert Hilbi
The ubiquitous environmental bacterium Legionella pneumophila survives and replicates within amoebae and human macrophages by forming a Legionella -containing vacuole (LCV). In an intricate process governed by the bacterial Icm/Dot type IV secretion system and a plethora of effector proteins, the nascent LCV interferes with a number of intracellular trafficking pathways, including retrograde transport from endosomes to the Golgi apparatus. Conserved retrograde trafficking components, such as the retromer coat complex or the phosphoinositide (PI) 5-phosphatase D...
June 1, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29565977/global-screening-for-critical-habitat-in-the-terrestrial-realm
#20
Kerstin M Brauneder, Chloe Montes, Simon Blyth, Leon Bennun, Stuart H M Butchart, Michael Hoffmann, Neil D Burgess, Annabelle Cuttelod, Matt I Jones, Val Kapos, John Pilgrim, Melissa J Tolley, Emma C Underwood, Lauren V Weatherdon, Sharon E Brooks
Critical Habitat has become an increasingly important concept used by the finance sector and businesses to identify areas of high biodiversity value. The International Finance Corporation (IFC) defines Critical Habitat in their highly influential Performance Standard 6 (PS6), requiring projects in Critical Habitat to achieve a net gain of biodiversity. Here we present a global screening layer of Critical Habitat in the terrestrial realm, derived from global spatial datasets covering the distributions of 12 biodiversity features aligned with guidance provided by the IFC...
2018: PloS One
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