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https://www.readbyqxmd.com/read/29929212/pharmacological-therapies-for-management-of-opium-withdrawal
#1
REVIEW
Afarin Rahimi-Movaghar, Jaleh Gholami, Laura Amato, Leila Hoseinie, Reza Yousefi-Nooraie, Masoumeh Amin-Esmaeili
BACKGROUND: Pharmacologic therapies for management of heroin withdrawal have been studied and reviewed widely. Opium dependence is generally associated with less severe dependence and milder withdrawal symptoms than heroin. The evidence on withdrawal management of heroin might therefore not be exactly applicable for opium. OBJECTIVES: To assess the effectiveness and safety of various pharmacologic therapies for the management of the acute phase of opium withdrawal...
June 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29928457/talking-about-end-of-life-care-in-a-timely-manner
#2
Frank W J M Smeenk, Laurien A Schrijver, Hennie C J van Bavel, Eric F J van de Laar
In 2014, a group of physicians of the Catharina Hospital in Eindhoven (The Netherlands) started a project called "Talking about end-of-life care in a timely manner". Just like others in the country, the Eindhoven group noticed that regularly, very frail elderly people were admitted to hospital in acute situations without there ever having been conversations about their wishes concerning treatment options at the end of life. The project aimed to prevent unnecessary admissions and treatments for these frail patients by stimulating physicians, patients and informal caregivers to start conversations about end-of-life care together at an earlier stage...
December 2017: Breathe
https://www.readbyqxmd.com/read/29927960/occupational-exposure-factors-for-mental-and-behavioral-disorders-at-work-the-forec-thesaurus
#3
Alain Chamoux, Céline Lambert, Audrey Vilmant, Charlotte Lanhers, Raymond Agius, Mounir Boutaleb, Vincent Bonneterre, Geraldine Naughton, Bruno Pereira, Khalid Djeriri, Eric Ben-Brik, Christine Breton, Caroline De Clavière, Corinne Letheux, Anne-Gaëlle Paolillo, Madeleine Valenty, Odile Vandenberghe, Marie-Pierre Aeschlimann, Gérard Lasfargues, Francois-Xavier Lesage, Frédéric Dutheil
BACKGROUND: Mental disorders in the workplace are a major public health problem. Knowledge of the impact of the psychosocial work environment on mental and behavioral disorders can assist occupational physicians in the identification and description of occupational risk situations, and help to define priority actions. However, no classification for occupational exposure factors is currently available. We aimed to build a thesaurus of "Organizational, Relational, Ethical and other Contributing Factors" (FOREC) linked with the onset of mental and behavioral disorders...
2018: PloS One
https://www.readbyqxmd.com/read/29927872/nutritional-considerations-in-pediatric-pancreatitis-a-position-paper-from-the-nasphan-pancreas-committee-and-esphan-cystic-fibrosis-pancreas-working-group
#4
Maisam Abu-El-Haija, Aliye Uc, Steven L Werlin, Alvin Jay Freeman, Miglena Georgieva, Danijela Jojkić-Pavkov, Daina Kalnins, Brigitte Kochavi, Bart G P Koot, Stephanie Van Biervliet, Jaroslaw Walkowiak, Michael Wilschanski, Veronique D Morinville
OBJECTIVES: Wide variations exist in how physicians manage the nutritional aspects of children affected by acute pancreatitis (AP), acute recurrent pancreatitis (ARP), and chronic (CP) pancreatitis. Better consensus for optimal management is needed. METHODS: This consensus statement on nutrition in pediatric pancreatic diseases was developed through a joint ESPGHAN-NASPGHAN working group that performed an evidence-based search of the literature on nutrition in AP, ARP, and CP with a focus on pediatrics...
July 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29927693/spontanuous-demand-for-meningococcal-b-vaccination-effects-on-appropriateness-and-timing
#5
A R Giuliani, A Mattei, A Appetiti, D Pompei, F Di Donna, F Fiasca, L Fabiani
When the meningococcus B vaccine was introduced into Italy in 2017, it was recommended for newborns based on national epidemiological data indicating that they were at greater risk. However, the vaccination service of the local health authority of L'Aquila had already been receiving spontaneous parental requests to provide vaccination for children in lower-risk age groups from the beginning of 2016. We therefore decided to use a self-administered questionnaire in order to investigate the parents' socio-demographic data; their children's history of other recommended vaccinations (against measles, mumps and rubella, varicella, meningococcus C and, for females, human papilloma virus); the information sources concerning meningococcal vaccination; and the timing of its administration...
June 21, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29927480/needs-and-preferences-of-patients-regarding-basal-cell-carcinoma-and-cutaneous-squamous-cell-carcinoma-care-a-qualitative-focus-group-study
#6
S van Egmond, M Wakkee, M Droger, M T Bastiaens, A van Rengen, K P de Roos, T Nijsten, M Lugtenberg
BACKGROUND: Despite the high and rising incidence rate of keratinocyte cancer (KC) and the importance of incorporating patient values in evidence-based care, few studies have focused on the perspectives of KC patients. OBJECTIVES: To identify the needs and preferences of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) patients regarding care. METHODS: A qualitative study consisting of three focus groups with BCC patients and three focus groups with SCC patients was conducted...
June 21, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29927346/the-effect-of-medical-technology-innovations-on-patient-outcomes-1990-2015-results-of-a-physician-survey
#7
David E Wamble, Michael Ciarametaro, Robert Dubois
BACKGROUND: Developments in diagnostics, medical devices, procedures, and prescription drugs have increased life expectancy and quality of life after diagnosis for many diseases. Previous research has shown that, overall, increased investment in medical technology has led to increased health outcomes. In addition, the value of investment in specific innovations, particularly in new pharmaceuticals or biopharmaceuticals, has frequently been shown through an evaluation of the associated health outcomes and costs...
June 21, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29926440/physician-knowledge-of-human-genetic-variation-beliefs-about-race-and-genetics-and-use-of-race-in-clinical-decision-making
#8
Sherrill L Sellers, Brooke A Cunningham, Vence L Bonham
BACKGROUND: Race in the USA has an enduring connection to health and well-being. It is often used as a proxy for ancestry and genetic variation, although self-identified race does not establish genetic risk of disease for an individual patient. How physicians reconcile these seemingly paradoxical facts as they make clinical decisions is unknown. OBJECTIVE: To examine physicians' genetic knowledge and beliefs about race with their use of race in clinical decision-making DESIGN: Cross-sectional survey of a national sample of clinically active general internists RESULTS: Seven hundred eighty-seven physicians completed the survey...
June 20, 2018: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29926389/the-virtual-toxicology-journal-club-the-dissemination-and-discussion-of-noteworthy-manuscripts-using-twitter
#9
Peter R Chai, Anne-Michelle Ruha, Kelly E Wong, Derek L Monette, Meghan B Spyres, Jeff Lapoint, Howard Greller, Mark B Mycyk
BACKGROUND: Twitter-based chat groups (tweetchats) structured as virtual journal clubs have been demonstrated to provide value to learners. In order to promote topics in medical toxicology, we developed the #firesidetox tweetchat as a virtual journal club to discuss and disseminate topics in medical toxicology. METHODS: A group of medical toxicologists from the American College of Medical Toxicology (ACMT) Public Affairs Committee and editorial board of the Journal of Medical Toxicology (JMT) developed a quarterly one hour tweetchat featuring JMT manuscripts...
June 20, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29926302/carotid-canal-and-optic-canal-at-sphenoid-sinus
#10
Neşe Asal, Nuray Bayar Muluk, Mikail Inal, Mehmet Hamdi Şahan, Adil Doğan, Osman Kürşat Arıkan
In the present study, we investigated the relationship between sphenoid sinus, carotid canal, and optic canal on paranasal sinus computed tomography (PNSCT). This study was performed retrospectively. PNSCT images of 300 adult subjects (159 male, 141 female). Sphenoid sinus (pneumatisation, dominancy, septation, inter-sinus septa deviation), anterior clinoid process pneumatisation, Onodi cell, carotid and optic canals (width, dehiscence, classification) were measured. In males, type 3 pneumatised sphenoid sinus (in both sides) and in females type 2 pneumatised sphenoid sinus (right side) and type 3 pneumatised sphenoid sinus (left side) were detected more...
June 21, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29925125/-technical-specification-for-clinical-application-of-critical-ultrasonography
#11
M G Yin, X T Wang, D W Liu, Y G Chao, X D Guan, Y Kang, J Yan, X C Ma, Y Q Tang, Z J Hu, K J Yu, D C Chen, Y H Ai, L N Zhang, H M Zhang, J Wu, L X Liu, R Zhu, W He, Q Zhang, X Ding, L Li, Y Li, H T Liu, Q B Zeng, X Si, H Chen, J W Zhang, Q H Xu, W J Chen, X K Chen, D Z Huang, S H Cai, X L Shang, J Guan, J Du, L Zhao, M J Wang, S Cui, X M Wang, R Zhou, X Y Zeng, Y P Wang, L W Lyu, W H Zhu, Y Zhu, J Duan, J Yang, H Yang
Critical ultrasonography(CUS) is different from the traditional diagnostic ultrasound, the examiner and interpreter of the image are critical care medicine physicians. The core content of CUS is to evaluate the pathophysiological changes of organs and systems and etiology changes. With the idea of critical care medicine as the soul, it can integrate the above information and clinical information, bedside real-time diagnosis and titration treatment, and evaluate the therapeutic effect so as to improve the outcome...
June 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29924655/genetic-mutations-and-demographic-clinical-and-morphological-aspects-of-myofibrillar-myopathy-in-a-french-cohort
#12
Alzira Alves de Siqueira Carvalho, Emmanuele Lacene, Guy Brochier, Clémance Labasse, Angeline Madelaine, Vinicius Gomes da Silva, Roseli Corazzini, Konstantinos Papadopoulos, Anthony Behin, Pascal Laforêt, Tania Stojkovic, Bruno Eymard, Michel Fardeau, Norma Romero
BACKGROUND: Protein aggregate myopathies (PAM) represent a group of familial or sporadic neuromuscular conditions with marked clinical and genetic heterogeneity that occur in children and adults. Familial PAM includes myofibrillar myopathies defined by the presence of desmin-positive protein aggregates and degenerative intermyofibrillar network changes. PAM is often caused by dysfunctional genes, such as DES, PLEC 1, CRYAB, FLNC, MYOT, ZASP, BAG3, FHL1, and DNAJB6. OBJECTIVE: To retrospectively analyze genetic mutations and demographic, clinical, and morphological aspects of PAM in a French population...
June 2018: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29924429/number-location-and-time-since-prior-fracture-as-predictors-of-future-fracture-in-elderly-from-the-general-population
#13
Claudia Beaudoin, Sonia Jean, Lynne Moore, Philippe Gamache, Louis Bessette, Louis-Georges Ste-Marie, Jacques P Brown
Prognostic tools are available to identify individuals at high risk of osteoporotic fracture and assist physicians in management decisions. Some authors have suggested improving the predictive ability of current tools by integrating characteristics of prior fractures (number, location and time since prior fracture). The objectives of this study were i) to evaluate the sex-age-specific association between characteristics of prior fractures and the occurrence of a future osteoporotic fracture and ii) to assess whether the characteristics of prior fractures could increase the discriminative ability of fracture risk prediction tools...
June 20, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29924011/clinical-inertia-in-the-pharmacological-management-of-hypertension-a-systematic-review-and-meta-analysis
#14
Tal Milman, Raed A Joundi, Naif M Alotaibi, Gustavo Saposnik
BACKGROUND: Clinical Inertia is defined as "failure of health care providers to initiate or intensify therapy according to current guidelines". This phenomenon is gaining increasing attention as a major cause of clinicians' failure to adequately manage hypertension, thus leading to an increased incidence of cardiovascular events. We performed a systematic review and meta-analysis of randomized controlled trials to determine whether interventions aimed at reducing clinical inertia in the pharmacological treatment of hypertension improve blood pressure (BP) control...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923025/cannabinoids-for-treatment-of-ms-symptoms-state-of-the-evidence
#15
REVIEW
Jessica Rice, Michelle Cameron
PURPOSE OF REVIEW: Cannabis and cannabinoids have been used medically and recreationally for thousands of years and recently there has been a growing body of research in this area. With increased access now that medical marijuana is available in many jurisdictions, patients and providers want to know more about the evidence for benefits and risks of cannabinoid use. This paper provides an overview of the available cannabinoid-based formulations, a summary of the highest quality evidence for the use of cannabinoids for treating spasticity and pain associated with multiple sclerosis (MS), and a discussion of possible dosing regimens based on information from these studies...
June 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29922491/immunological-emergency-in-neonate-case-report-and-role-of-early-screening
#16
Veronica Mugarab Samedi, Amy Shafey, Essa Al Awad, Luis Murguia Favela
Healthy looking newborns may have severe combined immunodeficiency (SCID), and neonatologists frequently are the first physicians to encounter these patients. Physicians usually have a high index of suspicion for this condition in presence of certain risk factors (unexplained infants' deaths, consanguinity); however, >80% of infants with SCID have no positive family history. A timely diagnosis of this condition is crucial in decreasing both mortality and morbidity. The only way to detect SCID prior to the onset of infections is newborn screening (NBS)...
April 2018: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/29921680/contribution-of-physician-assistants-associates-to-secondary-care-a-systematic-review
#17
Mary Halter, Carly Wheeler, Ferruccio Pelone, Heather Gage, Simon de Lusignan, Jim Parle, Robert Grant, Jonathan Gabe, Laura Nice, Vari M Drennan
OBJECTIVE: To appraise and synthesise research on the impact of physician assistants/associates (PA) in secondary care, specifically acute internal medicine, care of the elderly, emergency medicine, trauma and orthopaedics, and mental health. DESIGN: Systematic review. SETTING: Electronic databases (Medline, Embase, ASSIA, CINAHL, SCOPUS, PsycINFO, Social Policy and Practice, EconLit and Cochrane), reference lists and related articles. INCLUDED ARTICLES: Peer-reviewed articles of any study design, published in English, 1995-2017...
June 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29921528/diagnosis-of-alpha1-antitrypsin-deficiency-not-just-in-severe-copd
#18
A Nuñez, M Barrecheguren, E Rodríguez, M Miravitlles, C Esquinas
Alpha1-antitrypsin deficiency (AATD) is a well known genetic risk factor for pulmonary disease and is the most frequent hereditary disease diagnosed in adults. Despite being one of the most common hereditary diseases, AATD remains under-diagnosed because of its variable clinical presentation and the poor knowledge of this disease by physicians. With the aim of identifying clinical differences that could influence early diagnosis, we compared two groups of six AATD Pi*ZZ patients with different lung function severity and clinical expression at diagnosis...
June 16, 2018: Pulmonology
https://www.readbyqxmd.com/read/29921262/motivation-for-feedback-seeking-among-pediatric-residents-a-mixed-methods-study
#19
Duncan Henry, Travis Vesel, Christy Boscardin, Sandrijn van Schaik
BACKGROUND: For effective self-directed life-long learning physicians need to engage in feedback-seeking, which means fostering such behavior during training. Self-determination theory (SDT) posits that intrinsic motivation is fostered when the environment optimizes the individual's experience of autonomy, relatedness, and competence. Educational settings meeting these psychological needs may foster intrinsic motivation in trainees, enhance their desire for feedback, and promote feedback-seeking...
June 19, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29921255/effectiveness-of-the-blended-care-lifestyle-intervention-perfectfit-a-cluster-randomised-trial-in-employees-at-risk-for-cardiovascular-diseases
#20
Tessa A Kouwenhoven-Pasmooij, Suzan J W Robroek, Roderik A Kraaijenhagen, Pieter H Helmhout, Daan Nieboer, Alex Burdorf, M G Myriam Hunink
BACKGROUND: Web-based lifestyle interventions at the workplace have the potential to promote health and work productivity. However, the sustainability of effects is often small, which could be enhanced by adding face-to-face contacts, so-called 'blended care'. Therefore, this study evaluates the effects of a blended workplace health promotion intervention on health and work outcomes among employees with increased cardiovascular risk. METHODS: In this multicentre cluster-randomised controlled trial (PerfectFit), 491 workers in 18 work units from military, police, and a hospital with increased cardiovascular risk were randomised into two intervention groups...
June 19, 2018: BMC Public Health
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