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Fabrice Le Boeuf, Mohammed Selman, Hwan Hee Son, Anabel Bergeron, Andrew Chen, Jovian Tsang, Derek Butterwick, Rozanne Arulanandam, Nicole E Forbes, Fanny Tzelepis, John C Bell, Joel Werier, Hesham Abdelbary, Jean-Simon Diallo
The poor prognosis of patients with advanced bone and soft-tissue sarcoma has not changed in the past several decades, highlighting the necessity for new therapeutic approaches. Immunotherapies, including oncolytic viral (OV) therapy, have shown great promise in a number of clinical trials for a variety of tumor types. However, the effective application of OV in treating sarcoma still remains to be demonstrated. Although few pre-clinical studies using distinct OVs have been performed and demonstrated therapeutic benefit in sarcoma models, a side-by-side comparison of clinically relevant OV platforms has not been performed...
May 31, 2017: International Journal of Cancer. Journal International du Cancer
Almohanad A Alkayyal, Lee-Hwa Tai, Michael A Kennedy, Christiano Tanese de Souza, Jiqing Zhang, Charles Lefebvre, Shalini Sahi, Abhirami A Ananth, Ahmad Bakur Mahmoud, Andrew P Makrigiannis, Greg O Cron, Blair Macdonald, E Celia Marginean, David F Stojdl, John C Bell, Rebecca C Auer
Despite improvements in chemotherapy and radical surgical debulking, peritoneal carcinomatosis (PC) remains among the most common causes of death from abdominal cancers. Immunotherapies have been effective for selected solid malignancies, but their potential in PC has been little explored. Here, we report that intraperitoneal injection of an infected cell vaccine (ICV), consisting of autologous tumor cells infected ex vivo with an oncolytic Maraba MG1 virus expressing IL12, promotes the migration of activated natural killer (NK) cells to the peritoneal cavity in response to the secretion of IFNγ-induced protein-10 (IP-10) from dendritic cells...
February 3, 2017: Cancer Immunology Research
Laura Evgin, Carolina S Ilkow, Marie-Claude Bourgeois-Daigneault, Christiano Tanese de Souza, Lawton Stubbert, Michael S Huh, Victoria A Jennings, Monique Marguerie, Sergio A Acuna, Brian A Keller, Charles Lefebvre, Theresa Falls, Fabrice Le Boeuf, Rebecca A Auer, John D Lambris, J Andrea McCart, David F Stojdl, John C Bell
The systemic delivery of therapeutic viruses, such as oncolytic viruses or vaccines, is limited by the generation of neutralizing antibodies. While pseudotyping of rhabdoviruses with the lymphocytic choriomeningitis virus glycoprotein has previously allowed for multiple rounds of delivery in mice, this strategy has not translated to other animal models. For the first time, we provide experimental evidence that antibodies generated against the lymphocytic choriomeningitis virus glycoprotein mediate robust complement-dependent viral neutralization via activation of the classical pathway...
2016: Molecular Therapy Oncolytics
Eder Dos Santos Souza, Noé Carlos Barbosa Von Atzingen, Maria Betânia Furtado, Jader de Oliveira, Juliana Damieli Nascimento, Daniel Pagotto Vendrami, Sueli Gardim, João Aristeu da Rosa
Rhodnius marabaensissp. n. was collected on 12 May 2014 in the Murumurú Environmental Reserve in the city of Marabá, Pará State, Brazil. This study was based on previous consultation of morphological descriptions of 19 Rhodnius species and compared to the identification key for the genus Rhodnius. The examination included specimens from 18 Rhodnius species held in the Brazilian National and International Triatomine Taxonomy Reference Laboratory in the Oswaldo Cruz Institute in Rio de Janeiro, Brazil. The morphological characteristics of the head, thorax, abdomen, genitalia, and eggs have been determined...
2016: ZooKeys
Noriah Maraba, Aaron S Karat, Kerrigan McCarthy, Gavin J Churchyard, Salome Charalambous, Kathleen Kahn, Alison D Grant, Violet Chihota
BACKGROUND: Adults being investigated for TB in South Africa experience high mortality, yet causes of death (CoD) are not well defined. We determined CoD in this population using verbal autopsy (VA), and compared HIV- and TB-associated CoD using physician-certified verbal autopsy (PCVA) and InterVA-4 software. METHODS: All contactable consenting caregivers of participants who died during a trial comparing Xpert MTB/RIF to smear microscopy were interviewed using the WHO VA tool...
September 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
Marie-Claude Bourgeois-Daigneault, Lauren Elizabeth St-Germain, Dominic Guy Roy, Adrian Pelin, Amelia Sadie Aitken, Rozanne Arulanandam, Theresa Falls, Vanessa Garcia, Jean-Simon Diallo, John Cameron Bell
BACKGROUND: Breast cancer is the most common malignant disease amongst Western women. The lack of treatment options for patients with chemotherapy-resistant or recurrent cancers is pushing the field toward the rapid development of novel therapies. The use of oncolytic viruses is a promising approach for the treatment of disseminated diseases like breast cancer, with the first candidate recently approved by the Food and Drug Administration for use in patients. In this report, we demonstrate the compatibility of oncolytic virotherapy and chemotherapy using various murine breast cancer models...
August 8, 2016: Breast Cancer Research: BCR
Jiqing Zhang, Lee-Hwa Tai, Carolina S Ilkow, Almohanad A Alkayyal, Abhirami A Ananth, Christiano Tanese de Souza, Jiahu Wang, Shalini Sahi, Lundi Ly, Charles Lefebvre, Theresa J Falls, Kyle B Stephenson, Ahmad B Mahmoud, Andrew P Makrigiannis, Brian D Lichty, John C Bell, David F Stojdl, Rebecca C Auer
This study characterizes the ability of novel oncolytic rhabdoviruses (Maraba MG1) to boost natural killer (NK) cell activity. Our results demonstrate that MG1 activates NK cells via direct infection and maturation of conventional dendritic cells. Using NK depletion and conventional dendritic cells ablation studies in vivo, we established that both are required for MG1 efficacy. We further explored the efficacy of attenuated MG1 (nonreplicating MG1-UV(2min) and single-cycle replicating MG1-Gless) and demonstrated that these viruses activate conventional dendritic cells, although to a lesser extent than live MG1...
July 2014: Molecular Therapy: the Journal of the American Society of Gene Therapy
Mulu Z Tesfay, Arun Ammayappan, Mark J Federspiel, Glen N Barber, David Stojdl, Kah-Whye Peng, Stephen J Russell
UNLABELLED: Because of its very low human seroprevalence, vesicular stomatitis virus (VSV) has promise as a systemic oncolytic agent for human cancer therapy. However, as demonstrated in this report, the VSV infectious titer drops by 4 log units during the first hour of exposure to nonimmune human serum. This neutralization occurs relatively slowly and is mediated by the concerted actions of natural IgM and complement. Maraba virus, whose G protein is about 80% homologous to that of VSV, is relatively resistant to the neutralizing activity of nonimmune human serum...
June 2014: Journal of Virology
Jonathan G Pol, Liang Zhang, Byram W Bridle, Kyle B Stephenson, Julien Rességuier, Stephen Hanson, Lan Chen, Natasha Kazdhan, Jonathan L Bramson, David F Stojdl, Yonghong Wan, Brian D Lichty
The rhabdovirus Maraba has recently been characterized as a potent oncolytic virus. In the present study, we engineered an attenuated Maraba strain, defined as MG1, to express a melanoma-associated tumor antigen. Its ability to mount an antitumor immunity was evaluated in tumor-free and melanoma tumor-bearing mice. Alone, the MG1 vaccine appeared insufficient to prime detectable adaptive immunity against the tumor antigen. However, when used as a boosting vector in a heterologous prime-boost regimen, MG1 vaccine rapidly generated strong antigen-specific T-cell immune responses...
February 2014: Molecular Therapy: the Journal of the American Society of Gene Therapy
Steven J Pauszek, Jose Del C Barrera, Tony Goldberg, Rossana Allende, Luis L Rodriguez
Vesicular stomatitis (VS) viruses have been classified into two serotypes: New Jersey (VSNJV) and Indiana (VSIV). Here, we have characterized field isolates causing vesicular stomatitis in Brazil and Argentina over a 35-year span. Cluster analysis based on either serological relatedness, as inferred from virus neutralization and complement fixation assays, or nucleotide sequences of two separate genes (phosphoprotein or glycoprotein) grouped the field isolates into two distinct monophyletic groups within the Indiana serogroup...
November 2011: Archives of Virology
Danijela Koppers-Lalic, Rob C Hoeben
Viruses usually infect a restricted set of host species, and only in rare cases does productive infection occur outside the natural host range. Infection of a new host species can manifest as a distinct disease. In this respect, the use of non-human viruses in clinical therapy may be a cause for concern. It could provide the opportunity for the viruses to adapt to the new host and be transferred to the recipient's relatives or medical caretakers, or even to the normal host species. Such environmental impact is evidently undesirable...
July 2011: Reviews in Medical Virology
Jan Brun, Dan McManus, Charles Lefebvre, Kang Hu, Theresa Falls, Harold Atkins, John C Bell, J Andrea McCart, Douglas Mahoney, David F Stojdl
To expand our current array of safe and potent oncolytic viruses, we screened a variety of wild-type (WT) rhabdoviruses against a panel of tumor cell lines. Our screen identified a number of viruses with varying degrees of killing activity. Maraba virus was the most potent of these strains. We built a recombinant system for the Maraba virus platform, engineered a series of attenuating mutations to expand its therapeutic index, and tested their potency in vitro and in vivo. A double mutant (MG1) strain containing both G protein (Q242R) and M protein (L123W) mutations attenuated Maraba virus in normal diploid cell lines, yet appeared to be hypervirulent in cancer cells...
August 2010: Molecular Therapy: the Journal of the American Society of Gene Therapy
Joseane R de Souza, Evane Ferreira, Alberto Cargnelutti Filho, Arlindo L Boiça, Evandro F das Chagas, Janaína M Mondego
The genetic divergence of sixteen rice cultivars regarding their resistance to the rice stem bug, Tibraca limbativentris Stål, was estimated by multivariate analysis techniques. The experiment was carried out in greenhouse, in randomized block design with eight replications. Eight plant resistance related traits were evaluated. Genetic divergence was evaluated by multivariate procedures: generalized Mahalanobis (D(2)) distance, the Tocher's grouping optimization method and canonical variables. The most dissimilar cultivars were Bico Ganga and Marabá Branco, while Agulha and Branco Tardão were the most similar...
September 2009: Neotropical Entomology
Giselle Maria Rachid Viana, Ricardo Luís Dantas Machado, Vanja Sueli Pachiano Calvosa, Marinete Marins Póvoa
The objectives of this study were to investigate the molecular basis for Plasmodium falciparum resistance to chloroquine in isolates from the Brazilian Amazon and to identify polymorphisms in the pfmdr1 gene, codons 184, 1042, and 1246, the kappa and gamma regions of the cg2 gene, and the K76T mutation of the pfcrt gene, in order to calculate the distribution of polymorphism within each target gene, comparing samples from distinct geographic areas, using allele-specific polymerase chain reaction (PCR) for the pfmdr gene and PCR plus restriction fragment length polymorphism (RFLP) for the cg2 and pfcrt genes...
December 2006: Cadernos de Saúde Pública
M Boulos, A C Ceneviva, M Shiroma, M E Camargo, E A de Castilho
No abstract text is available yet for this article.
January 1984: Revista do Instituto de Medicina Tropical de São Paulo
A P Travassos da Rosa, R B Tesh, J F Travassos da Rosa, J P Herve, A J Main
Two new rhabdoviruses, designated Carajas and Maraba, are described. Both were isolated from phlebotomine sand flies (Lutzomyia spp.) collected in the Amazon basin of Brazil. One recovery of Carajas virus was made from male sand flies. By complement-fixation and neutralization tests both agents were shown to be members of the vesicular stomatitis virus (VSV) serogroup (genus Vesiculovirus). The pathogenicity of the two viruses in mice and Vero cells is similar to that of VSV-Indiana and VSV-New Jersey. Both Carajas and Maraba viruses replicated in Lutzomyia longipalpis following intrathoracic inoculation, and both agents were transovarially transmitted in this sand fly species...
September 1984: American Journal of Tropical Medicine and Hygiene
R B Tesh, J Boshell, G B Modi, A Morales, D G Young, A Corredor, C Ferro de Carrasquilla, C de Rodriguez, L L Walters, M O Gaitan
Five isolations of the Alagoas serotype of vesicular stomatitis virus (Rhabdoviridae: Vesiculovirus) were made from naturally infected phlebotomine sand flies (Lutzomyia spp.) collected in Colombia. These are the first isolations of Alagoas virus from an arthropod. Replication of the virus occurred in laboratory-reared sand flies (Lutzomyia longipalpis) after inoculation. Bite and transovarial transmission of the virus was also demonstrated in experimentally infected sand flies. Alagoas virus neutralizing antibodies were found in sera of humans and animals living near the insect collection site; antibody rates among human residents of two nearby towns were 63% and 83%, respectively...
May 1987: American Journal of Tropical Medicine and Hygiene
M Trigo, M J Roncada, G T Stewien, I M Pereira
A study was carried out into alimentary taboos in two localities (São Félix and Murumuru) in the county of Marabá, State of Pará, Brazil. Ninety families were studied in São Félix and thirty-five in Murumuru. As regards the feeding taboos found, the most frequent was that prohibiting the simultaneous ingestion of milk and various types of fruit, including especially mango, orange, cashew and pineapple. The ingestion of eggs with fruit was also considered harmful as well as the eating of mammalian flesh at the same time as fish...
December 1989: Revista de Saúde Pública
M Netto, E Y Egry
No abstract text is available yet for this article.
July 1976: Revista Enfermagem Em Novas Dimensões
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