Luke W Desmond, Evan M Holbrook, Caelan T O Wright, Cristian A Zambrano, Christopher E Stamper, Adam D Bohr, Matthew G Frank, Brendan K Podell, Julie A Moreno, Andrew S MacDonald, Stefan O Reber, Rogelio Hernández-Pando, Christopher A Lowry
Previous studies have shown that the in vivo administration of soil-derived bacteria with anti-inflammatory and immunoregulatory properties, such as Mycobacterium vaccae NCTC 11659, can prevent a stress-induced shift toward an inflammatory M1 microglial immunophenotype and microglial priming in the central nervous system (CNS). It remains unclear whether M. vaccae NCTC 11659 can act directly on microglia to mediate these effects. This study was designed to determine the effects of M. vaccae NCTC 11659 on the polarization of naïve BV-2 cells, a murine microglial cell line, and BV-2 cells subsequently challenged with lipopolysaccharide (LPS)...
December 29, 2023: International Journal of Molecular Sciences