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https://www.readbyqxmd.com/read/28781966/obesity-increases-prevalence-of-colonic-adenomas-at-screening-colonoscopy-a-canadian-community-based-study
#1
Theodore F Shapero, Grant I Chen, Tim Devlin, Alison Gibbs, Iain C Murray, Stanley Tran, Corey Weigensberg
BACKGROUND AND AIMS: Obesity is a risk factor for colorectal neoplasia. We examined the influence of obesity and metabolic syndrome (MetS) on prevalence of neoplasia at screening colonoscopy. METHODS: We evaluated 2020 subjects undergoing first screening colonoscopy. Body mass index (BMI) was calculated at enrolment. Hyperlipidemia (HL), hypertension (HT), and diabetes mellitus (DM) were identified. Details of colonoscopy, polypectomy, and histology were recorded...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28780512/repeated-administration-of-dapirolizumab-pegol-in-a-randomised-phase-i-study-is-well-tolerated-and-accompanied-by-improvements-in-several-composite-measures-of-systemic-lupus-erythematosus-disease-activity-and-changes-in-whole-blood-transcriptomic-profiles
#2
Chris Chamberlain, Peter J Colman, Ann M Ranger, Linda C Burkly, Geoffrey I Johnston, Christian Otoul, Christian Stach, Miren Zamacona, Thomas Dörner, Murray Urowitz, Falk Hiepe
OBJECTIVES: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease associated with diffuse immune cell dysfunction. CD40-CD40 ligand (CD40L) interaction activates B cells, antigen-presenting cells and platelets. CD40L blockade might provide an innovative treatment for systemic autoimmune disorders. We investigated the safety and clinical activity of dapirolizumab pegol, a polyethylene glycol conjugated anti-CD40L Fab' fragment, in patients with SLE. METHODS: This 32-week randomised, double-blind, multicentre study (NCT01764594) evaluated repeated intravenous administration of dapirolizumab pegol in patients with SLE who were positive for/had history of antidouble stranded DNA/antinuclear antibodies and were on stable doses of immunomodulatory therapies (if applicable)...
August 5, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28775077/chronic-rejection-of-cardiac-allografts-is-associated-with-increased-lymphatic-flow-and-cellular-trafficking
#3
Lindsey A Edwards, Anna K Nowocin, Nazila V Jafari, Lucy Meader, Kathryn Brown, Aurélien Sarde, Carolyn Lam, Alex Murray, Wilson Wong
Background -Cardiac transplantation is an excellent treatment for end-stage heart disease. However, rejection of the donor graft, particularly by chronic rejection leading to cardiac allograft vasculopathy, remains a major cause of graft loss. The lymphatic system plays a crucial role in the alloimmune response, facilitating trafficking of antigen presenting cells (APCs) to draining lymph nodes (dLN). The encounter of APCs with T lymphocytes in secondary lymphoid organs is essential for the initiation of alloimmunity...
August 3, 2017: Circulation
https://www.readbyqxmd.com/read/28774467/incorporating-the-length-dependent-passive-force-generating-muscle-properties-of-the-extrinsic-finger-muscles-into-a-wrist-and-finger-biomechanical-musculoskeletal-model
#4
Benjamin I Binder-Markey, Wendy M Murray
Dynamic movement trajectories of low mass systems have been shown to be predominantly influenced by passive viscoelastic joint forces and torques compared to momentum and inertia. The hand is comprised of 27smallmass segments. Because of the influence of the extrinsic finger muscles, the passive torques about each finger joint become a complex function dependent on the posture of multiple joints of the distal upper limb. However, biomechanical models implemented for the dynamic simulation of hand movements generally don't extend proximally to include the wrist and distal upper limb...
June 21, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28768778/which-factors-influence-the-rate-of-failure-following-metal-on-metal-hip-arthroplasty-revision-surgery-performed-for-adverse-reactions-to-metal-debris-an-analysis-from-the-national-joint-registry-for-england-and-wales
#5
G S Matharu, A Judge, H G Pandit, D W Murray
AIMS: To determine the outcomes following revision surgery of metal-on-metal hip arthroplasties (MoMHA) performed for adverse reactions to metal debris (ARMD), and to identify factors predictive of re-revision. PATIENTS AND METHODS: We performed a retrospective observational study using National Joint Registry (NJR) data on 2535 MoMHAs undergoing revision surgery for ARMD between 2008 and 2014. The outcomes studied following revision were intra-operative complications, mortality and re-revision surgery...
August 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28752567/auditory-visual-integration-modulates-location-specific-repetition-suppression-of-auditory-responses
#6
Talia Shrem, Micah M Murray, Leon Y Deouell
Space is a dimension shared by different modalities, but at what stage spatial encoding is affected by multisensory processes is unclear. Early studies observed attenuation of N1/P2 auditory evoked responses following repetition of sounds from the same location. Here, we asked whether this effect is modulated by audiovisual interactions. In two experiments, using a repetition-suppression paradigm, we presented pairs of tones in free field, where the test stimulus was a tone presented at a fixed lateral location...
July 28, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28750677/inhaled-ap301-for-treatment-of-pulmonary-edema-in-mechanically-ventilated-patients-with-acute-respiratory-distress-syndrome-a-phase-iia-randomized-placebo-controlled-trial
#7
Katharina Krenn, Rudolf Lucas, Adrien Croizé, Stefan Boehme, Klaus Ulrich Klein, Robert Hermann, Klaus Markstaller, Roman Ullrich
BACKGROUND: High-permeability pulmonary edema is a hallmark of acute respiratory distress syndrome (ARDS) and is frequently accompanied by impaired alveolar fluid clearance (AFC). AP301 enhances AFC by activating epithelial sodium channels (ENaCs) on alveolar epithelial cells, and we investigated its effect on extravascular lung water index (EVLWI) in mechanically ventilated patients with ARDS. METHODS: Forty adult mechanically ventilated patients with ARDS were included in a randomized, double-blind, placebo-controlled trial for proof of concept...
July 27, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28745903/trend-of-socio-demographic-index-and-mortality-estimates-in-iran-and-its-neighbors-1990-2015-findings-of-the-global-burden-of-diseases-2015-study
#8
Maziar Moradi-Lakeh, Sadaf G Sepanlou, Seyed M Karimi, Narjes Khalili, Shirin Djalalinia, Chante Karimkhani, Kristopher Krohn, Ashkan Afshin, Farshad Farzadfar, Aliasghar Ahmad Kiadaliri, Mohsen Asadi-Lari, Hamid Asayesh, Ali Reza Esteghamati, Maryam S Farvid, Seyed-Mohammad Fereshtehnejad, Pouria Heydarpour, Ardeshir Khosravi, Jagdish Khubchandani, Amir Kasaeian, Saleem M Rana, Mahdi Mahdavi, Habib Masoudifarid, Alireza Mohammadi, Farshad Pourmalek, Mostafa Qorbani, Amir Radfar, Kazem Rahimi, Vafa Rahimi-Movaghar, Gholamreza Roshandel, Sare Safi, Payman Salamati, Arash Tehrani-Banihashemi, Shahrzad Bazargan-Hejazi, Theo Vos, Reza Malekzadeh, Ali H Mokdad, Christopher J L Murray, Mohsen Naghavi
BACKGROUND: The Global burden of disease and injuries study (GBD 2015) reports expected measures for years of life lost (YLL) based on socio-demographic index (SDI) of countries, as well as the observed measures. In this extended GBD 2015 report, we reviewed total and cause-specific deaths and YLL for Iran and all its neighboring countries between 1990 and 2015. METHODS: We extracted data from the GBD 2015 database. Observed YLL measures were calculated by multiplying the number of deaths by standard life expectancy at each age...
July 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28745902/disability-adjusted-life-years-dalys-for-315-diseases-and-injuries-and-healthy-life-expectancy-hale-in-iran-and-its-neighboring-countries-1990-2015-findings-from-global-burden-of-disease-study-2015
#9
Sadaf G Sepanlou, Mahboubeh Parsaeian, Kristopher J Krohn, Ashkan Afshin, Farshad Farzadfar, Gholamreza Roshandel, Chante Karimkhani, Sharzad Bazargan-Hejazi, Aliasghar Ahmad Kiadaliri, Hamid Ahmadieh, Shirin Djalalinia, Hedyeh Ebrahimi, Babak Eshrati, Ali Reza Esteghamati, Maryam S Farvid, Seyed-Mohammad Fereshtehnejad, Nima Hafezi-Nejad, Mohammad Sadegh Hassanvand, Pouria Heydarpour, Farhad Islami, Seyed M Karimi, Marzieh Katibeh, Ardeshir Khosravi, Jagdish Khubchandani, Mahdi Mahdavi, Farhad Pishgar, Mostafa Qorbani, Vafa Rahimi-Movaghar, Sare Safi, Mohammad Ali Sahraian, Saeid Shahraz, Sara Sheikhbahaei, Alireza Mohammadi, Ali H Mokdad, Theo Vos, Christopher J L Murray, Maziar Moradi-Lakeh, Mohsen Naghavi, Reza Malekzadeh
BACKGROUND: Summary measures of health are essential in making estimates of health status that are comparable across time and place. They can be used for assessing the performance of health systems, informing effective policy making, and monitoring the progress of nations toward achievement of sustainable development goals. The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) provides disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) as main summary measures of health...
July 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28738902/a-comparative-effectiveness-study-of-two-culturally-competent-models-of-diabetes-self-management-programming-for-latinos-from-low-income-households
#10
Janet Page-Reeves, Lidia Regino, Cristina Murray-Krezan, Molly Bleecker, Erik Erhardt, Mark Burge, Elaine Bearer, Shiraz Mishra
BACKGROUND: Diabetes risk is extremely high for Latinos from low-income households. Health guidelines recommend that individuals learn strategies to self-manage their diabetes, but getting people to adopt required lifestyle changes is challenging and many people are not able to prevent their pre-diabetes from escalating or effectively control their diabetes. Systematic reviews show that culturally competent self-management programs can significantly improve diabetes outcomes and different models for culturally competent programming have been developed...
July 24, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28705956/rapid-recovery-gene-downregulation-during-excess-light-stress-and-recovery-in-arabidopsis
#11
Peter Alexander Crisp, Diep Ganguly, Aaron B Smith, Kevin D Murray, Gonzalo M Estavillo, Iain R Searle, Ethan Ford, Ozren Bogdanović, Ryan Lister, Justin O Borevitz, Steven R Eichten, Barry J Pogson
Stress recovery may prove to be a promising approach to increase plant performance, and theoretically, mRNA instability may facilitate faster recovery. Transcriptome (RNA-seq, qPCR, sRNA-seq, PARE) and methylome profiling during repeated excess-light stress and recovery was performed at intervals as short as three minutes. We demonstrate that 87% of the stress-upregulated mRNAs analysed exhibit very rapid recovery. For instance, HSP101 abundance declined two-fold every 5.1 minutes. We term this phenomenon Rapid Recovery Gene Downregulation (RRGD), whereby mRNA abundance rapidly decreases promoting transcriptome resetting...
July 13, 2017: Plant Cell
https://www.readbyqxmd.com/read/28705600/poor-medication-adherence-and-risk-of-relapse-associated-with-continued-cannabis-use-in-patients-with-first-episode-psychosis-a-prospective-analysis
#12
Tabea Schoeler, Natalia Petros, Marta Di Forti, Ewa Klamerus, Enrico Foglia, Robin Murray, Sagnik Bhattacharyya
BACKGROUND: Cannabis use following the onset of first-episode psychosis has been linked to both increased risk of relapse and non-adherence with antipsychotic medication. Whether poor outcome associated with cannabis use is mediated through an adverse effect of cannabis on medication adherence is unclear. METHODS: In a prospective analysis of data acquired from four different adult inpatient and outpatient units of the South London and Maudsley Mental Health National Health Service Foundation Trust in London, UK, 245 patients were followed up for 2 years from the onset of first-episode psychosis...
August 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28689952/a-novel-off-the-shelf-technique-for-endovascular-repair-of-type-iii-and-iv-thoracoabdominal-aortic-aneurysms-using-the-gore-excluder-and-viabahn-branches
#13
Mathew Wooster, Adam Tanious, R Wesley Jones, Paul Armstrong, Murray Shames
OBJECTIVE: To describe the use of a novel off-the-shelf technique to repair type III and type IV thoracoabdominal aortic aneurysms (TAAA) in absence of available prefabricated branched devices. METHODS: All patients undergoing endovascular repair of type III and IV TAAAs using this technique were included from a prospectively maintained registry at a regional aortic referral center. The proximal bifurcated Gore C3 Excluder device is positioned in the descending thoracic aorta with the contralateral gate 2-3 cm above the celiac artery...
July 6, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28682006/air-trapping-in-early-cystic-fibrosis-lung-disease-does-ct-tell-the-full-story
#14
Tim Rosenow, Kathryn Ramsey, Lidija Turkovic, Conor P Murray, L Clara Mok, Graham L Hall, Stephen M Stick
INTRODUCTION: Mosaic attenuation on expiratory chest computed tomography (CT) is common in early life cystic fibrosis (CF) and often referred to as "air trapping". It is presumed to be localized hyperinflation due to small airway obstruction. In order to test this assumption, we compared air trapping extent to lung volumes measured on CT in young children with CF. MATERIALS AND METHODS: Children aged below 7 years undergoing inspiratory/expiratory CT were recruited from the Australian Respiratory Early Surveillance Team for Cystic Fibrosis cohort...
July 6, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28673802/regular-activity-breaks-combined-with-physical-activity-improve-postprandial-plasma-triglyceride-nonesterified-fatty-acid-and-insulin-responses-in-healthy-normal-weight-adults-a-randomized-crossover-trial
#15
Ashleigh R Homer, Stephen P Fenemor, Tracy L Perry, Nancy J Rehrer, Claire M Cameron, C Murray Skeaff, Meredith C Peddie
BACKGROUND: Compared with prolonged sitting, regular activity breaks immediately lower postprandial glucose and insulin, but not triglyceride responses. Postprandial triglycerides can be lowered by physical activity but the effect is often delayed by ∼12 to 24 hours. OBJECTIVE: The objective of the study was to determine whether regular activity breaks affect postprandial triglyceride response in a delayed manner similar to physical activity. METHODS: In a randomized crossover trial, 36 adults (body mass index 23...
June 19, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28662555/cardiovascular-disease-risk-factors-after-an-employer-based-risk-reduction-program-an-observational-cohort-study
#16
David H Holben, Chelsea Rambo, Cheryl Howe, Deborah H Murray, Jay H Shubrook
Context: The burden of cardiovascular disease (CVD) continues to be a public health concern. Workplace interventions that focus on modifying lifestyle habits may reduce CVD risk factors in people at risk. Objective: To determine the effectiveness of a comprehensive lifestyle intervention program that integrated dietary modification, physical activity, stress management, and behavior modification counseling to reduce the risk of CVD in at-risk adults. Methods: Twelve 1-year cohorts who participated in a comprehensive employer-sponsored lifestyle intervention program targeting diet, exercise, behavior modification, and stress management between 2006 and 2010 at a rural university in Appalachian Ohio were studied...
July 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28644513/benign-vascular-lesions-of-the-breast-diagnosed-by-core-needle-biopsy-do-not-require-excision
#17
Christopher Sebastiano, Lucas Gennaro, Edi Brogi, Elizabeth Morris, Zenica L Bowser, Cristina R Antonescu, Fresia Pareja, Sandra Brennan, Melissa P Murray
AIMS: Surgical excision of all benign vascular lesions of the breast identified by core needle biopsy has been recommended in the past to rule out a more serious lesion. In this study we investigated the clinical, radiologic, and pathologic findings in patients diagnosed with a benign vascular lesion at our institution to assess whether excision may be spared for lesions without atypia. METHODS AND RESULTS: We searched the electronic medical record for patients with a vascular lesion of the breast diagnosed between 2000 and 2015...
June 23, 2017: Histopathology
https://www.readbyqxmd.com/read/28623527/updating-the-evidence-of-the-interaction-between-clopidogrel-and-cyp2c19-inhibiting-selective-serotonin-reuptake-inhibitors-a-cohort-study-and-meta-analysis
#18
Katsiaryna Bykov, Sebastian Schneeweiss, Robert J Glynn, Murray A Mittleman, David W Bates, Joshua J Gagne
INTRODUCTION: We previously found that patients who initiate clopidogrel while treated with a cytochrome P450 (CYP) 2C19-inhibiting selective serotonin reuptake inhibitor (SSRI) have a higher risk of subsequent ischemic events than patients treated with other SSRIs. It is not known whether initiating an inhibiting SSRI while treated with clopidogrel will also increase risk of ischemic events. OBJECTIVE: The aim of this study was to assess clinical outcomes following initiation of a CYP2C19-inhibiting SSRI versus initiation of other SSRIs among patients treated with clopidogrel and to update existing evidence on the clinical impact of clopidogrel-SSRI interaction...
June 16, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28614739/assessment-of-soil-water-carbon-and-nitrogen-cycling-in-reseeded-grassland-on-the-north-wyke-farm-platform-using-a-process-based-model
#19
Yuefen Li, Yi Liu, Paul Harris, Hadewij Sint, Phil J Murray, Michael R F Lee, Lianhai Wu
The North Wyke Farm Platform (NWFP) generates large volumes of temporally-indexed data that provides a valuable test-bed for agricultural mathematical models in temperate grasslands. In our study, we used the primary datasets generated from the NWFP (https://nwfp.rothamsted.ac.uk/) to validate the SPACSYS model in terms of the dynamics of water loss and forage dry matter yield estimated through cutting. The SPACSYS model is capable of simulating soil water, carbon (C) and nitrogen (N) balance in the soil-plant-atmosphere system...
December 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28602530/prospective-randomized-surgeon-blinded-comparison-of-standard-magnification-assumption-vs-magnification-marker-usage-for-preoperative-templating-in-total-hip-arthroplasty
#20
Michael J Archibeck, Krishna R Tripuraneni, Joshua T Carothers, Daniel W Junick, Natalie R Munson, Cristina M Murray-Krezan
BACKGROUND: We undertook this prospective, randomized, surgeon-blinded study to compare the accuracy of using of a magnification marker on preoperative radiographs for templating vs using a standard 21% magnification. METHODS: One hundred consecutive total hip arthroplasties were randomized to preoperative templating using a 25-mm magnification marker (50 patients) or a standard 21% magnification (50 patients). Intraoperative data were collected regarding the actual and predicted size of the femoral and acetabular components...
May 17, 2017: Journal of Arthroplasty
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