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https://www.readbyqxmd.com/read/28211899/spatial-regularity-of-inas-gaas-quantum-dots-quantifying-the-dependence-of-lateral-ordering-on-growth-rate
#1
T Konishi, E Clarke, C W Burrows, J J Bomphrey, R Murray, G R Bell
The lateral ordering of arrays of self-assembled InAs-GaAs quantum dots (QDs) has been quantified as a function of growth rate, using the Hopkins-Skellam index (HSI). Coherent QD arrays have a spatial distribution which is neither random nor ordered, but intermediate. The lateral ordering improves as the growth rate is increased and can be explained by more spatially regular nucleation as the QD density increases. By contrast, large and irregular 3D islands are distributed randomly on the surface. This is consistent with a random selection of the mature QDs relaxing by dislocation nucleation at a later stage in the growth, independently of each QD's surroundings...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28196035/perivascular-stem-cells-diminish-muscle-atrophy-following-massive-rotator-cuff-tears-in-a-small-animal-model
#2
Claire D Eliasberg, Ayelet Dar, Andrew R Jensen, Iain R Murray, Winters R Hardy, Tomasz J Kowalski, Cameron A Garagozlo, Kyle M Natsuhara, Adam Z Khan, Owen J McBride, Peter I Cha, Benjamin V Kelley, Denis Evseenko, Brian T Feeley, David R McAllister, Bruno Péault, Frank A Petrigliano
BACKGROUND: Rotator cuff tears are a common cause of shoulder pain and often necessitate operative repair. Muscle atrophy, fibrosis, and fatty infiltration can develop after rotator cuff tears, which may compromise surgical outcomes. This study investigated the regenerative potential of 2 human adipose-derived progenitor cell lineages in a murine model of massive rotator cuff tears. METHODS: Ninety immunodeficient mice were used (15 groups of 6 mice). Mice were assigned to 1 of 3 surgical procedures: sham, supraspinatus and infraspinatus tendon transection (TT), or TT and denervation via suprascapular nerve transection (TT + DN)...
February 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28195882/the-in-hospital-cost-of-ventricular-assist-device-therapy-implications-for-patient-selection
#3
Amit Iyengar, Oh Jin Kwon, Msgana Tamrat, Anthony Salimbangon, Nancy Satou, Peyman Benharash, Abbas Ardehali, Richard J Shemin, Murray H Kwon
Ventricular Assist Device (VAD) therapy is increasingly utilized to support patients in end-stage heart failure. However, VAD programs are resource intensive and demand active monitoring in order to ensure long term sustainability. The purpose of this study was to analyze total cost trends of the VAD program at our academic medical center.Retrospective analysis of UCLA's VAD program between years 2013-2014 was performed. Total in-hospital costs from the date of VAD surgery admission were queried and normalized to a Z-score...
February 9, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28188643/will-i-get-fat-22-year-weight-trajectories-of-individuals-with-eating-disorders
#4
Helen B Murray, Nassim Tabri, Jennifer J Thomas, David B Herzog, Debra L Franko, Kamryn T Eddy
OBJECTIVE: For some, fat phobia or fear of uncontrollable weight gain is diagnostic of eating disorders, often inhibiting treatment engagement and predicting symptom relapse. Prior research has reported weight changes at infrequent or long intervals, but rate, shape, and magnitude of long-term changes remain unknown. Our study examined 22-year longitudinal trajectories of body mass index (BMI) in women with anorexia nervosa (AN) and bulimia nervosa (BN). METHOD: Participants were followed over 10 years (N = 225) and at 22-year follow-up (N = 175)...
February 11, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28169971/health-related-quality-of-life-in-pediatric-patients-with-chronic-hepatitis-b-living-in-the-united-states-and-canada
#5
Sarah Jane Schwarzenberg, Simon C Ling, Yona Keich Cloonan, Hsing-Hua S Lin, Donna M Evon, Karen F Murray, Norberto Rodriguez-Baez, Philip Rosenthal, Jeffrey Teckman, Kathleen B Schwarz
OBJECTIVES: To determine if selected socio-demographic and HBV-specific clinical factors are associated with health-related quality of life (HRQoL) among pediatric patients chronically infected with hepatitis B virus (HBV). METHODS: Children with chronic HBV enrolled in the Hepatitis B Research Network completed the Child Health Questionnaire (CHQ) at study entry. Caregivers of children 5- < 10 years completed the parent-reported PF50; youth 10- < 18 years completed the child-reported CF87...
February 4, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28166635/engineering-localized-surface-plasmon-interactions-in-gold-by-silicon-nanowire-for-enhanced-heating-and-photocatalysis
#6
Daksh Agarwal, Carlos Aspetti, Matteo Cargnello, Mingliang Ren, Jinkyoung Yoo, Christopher B Murray, Ritesh Agarwal
The field of plasmonics has attracted considerable attention in recent years because of potential applications in various fields such as nanophotonics, photovoltaics, energy conversion, catalysis and therapeutics. It is becoming increasing clear that intrinsic high losses associated with plasmons can be utilized to create new device concepts to harvest the generated heat. It is therefore important to design cavities, which can harvest optical excitations efficiently to generate heat. We report a highly engineered nanowire cavity, which utilizes a high dielectric silicon core with a thin plasmonic film (Au) to create an effective metallic cavity to strongly confine light, which when coupled with localized surface plasmons in the nanoparticles of the thin metal film produces exceptionally high temperatures upon laser irradiation...
February 6, 2017: Nano Letters
https://www.readbyqxmd.com/read/28151767/increasing-incidence-and-altered-presentation-in-a-population-based-study-of-pediatric-celiac-disease-in-north-america
#7
Eyad Almallouhi, Katherine S King, Bhavisha Patel, Chung Wi, Young J Juhn, Joseph A Murray, Imad Absah
OBJECTIVES: Celiac disease (CD) is a common immune-mediated disorder that affects up to 1% of the general population. Recent reports suggest that the incidence of CD has reached a plateau in many countries. We aim to study the incidence and altered presentation of childhood CD in a well-defined population. METHODS: Using the Rochester Epidemiology Project, we retrospectively reviewed Mayo Clinic and Olmsted Medical Center medical records from January 1994 to December 2014...
February 1, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28107888/anxiety-and-anger-immediately-prior-to-myocardial-infarction-and-long-term-mortality-characteristics-of-high-risk-patients
#8
Loes Smeijers, Elizabeth Mostofsky, Geoffrey H Tofler, James E Muller, Willem J Kop, Murray A Mittleman
OBJECTIVE: Acute high levels of anger and anxiety are associated with an elevated risk of myocardial infarction (MI) in the following two hours. MIs preceded by these acute negative emotions may also have a poor long-term prognosis, but information about high-risk patients is lacking. We examined whether young age and female sex are associated with MIs that are preceded by negative emotions and whether age and sex moderate the subsequent increased mortality risk following MI preceded by negative emotions...
February 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28087266/assessment-of-sex-differences-in-body-composition-among-adolescents-with-anorexia-nervosa
#9
Jason M Nagata, Neville H Golden, Rebecka Peebles, Jin Long, Stuart B Murray, Mary B Leonard, Jennifer L Carlson
PURPOSE: To compare deficits in fat mass (FM) and lean body mass (LM) among male and female adolescents with anorexia nervosa (AN) and to identify other covariates associated with body composition. METHODS: We retrospectively reviewed electronic medical records of all subjects aged 9-20 years with a Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition diagnosis of AN and dual-energy x-ray absorptiometry scans after initial evaluation at Stanford between March 1997 and February 2011...
January 11, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28078381/celiac-disease-a-clinical-review
#10
Badr Al-Bawardy, D Chamil Codipilly, Alberto Rubio-Tapia, David H Bruining, Stephanie L Hansel, Joseph A Murray
Celiac disease (CD) is an immune-mediated inflammatory enteropathy triggered by gluten exposure in genetically susceptible individuals. It has a high prevalence approaching 1% of the US population. A high index of suspicion is warranted to diagnose CD as frequently patients present with extraintestinal or atypical manifestations. CD is diagnosed by a combination of serum serologies and duodenal biopsies. The majority of patients will respond to a lifelong gluten-free diet which is the cornerstone of therapy...
January 12, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28073954/gene-obesogenic-environment-interactions-in-the-uk-biobank-study
#11
Jessica Tyrrell, Andrew R Wood, Ryan M Ames, Hanieh Yaghootkar, Robin N Beaumont, Samuel E Jones, Marcus A Tuke, Katherine S Ruth, Rachel M Freathy, George Davey Smith, Stéphane Joost, Idris Guessous, Anna Murray, David P Strachan, Zoltán Kutalik, Michael N Weedon, Timothy M Frayling
BACKGROUND: Previous studies have suggested that modern obesogenic environments accentuate the genetic risk of obesity. However, these studies have proven controversial as to which, if any, measures of the environment accentuate genetic susceptibility to high body mass index (BMI). METHODS: We used up to 120 000 adults from the UK Biobank study to test the hypothesis that high-risk obesogenic environments and behaviours accentuate genetic susceptibility to obesity...
January 10, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28060532/critical-slowing-down-as-an-early-warning-of-transitions-in-episodes-of-bipolar-disorder-a-simulation-study-based-on-a-computational-model-of-circadian-activity-rhythms
#12
Atiyeh Bayani, Fatemeh Hadaeghi, Sajad Jafari, Greg Murray
Bipolar disorder is characterized by repeated episodes of mania and depression, and can be understood as pathological complex system behaviour involving cognitive, affective and psychomotor disturbance. Accurate prediction of episode transitions in the long-term pattern of mood changes in bipolar disorder could improve the management of the disorder by providing an objective early warning of relapse. In particular, circadian activity changes measured via actigraphy may contain clinically relevant signals of imminent systemic dysregulation...
2017: Chronobiology International
https://www.readbyqxmd.com/read/28045996/validation-of-immune-cell-modules-in-multicellular-transcriptomic-data
#13
Gabriele Pollara, Matthew J Murray, James M Heather, Rachel Byng-Maddick, Naomi Guppy, Matthew Ellis, Carolin T Turner, Benjamin M Chain, Mahdad Noursadeghi
Numerous gene signatures, or modules have been described to evaluate the immune cell composition in transcriptomes of multicellular tissue samples. However, significant diversity in module gene content for specific cell types is associated with heterogeneity in their performance. In order to rank modules that best reflect their purported association, we have generated the modular discrimination index (MDI) score that assesses expression of each module in the target cell type relative to other cells. We demonstrate that MDI scores predict modules that best reflect independently validated differences in cellular composition, and correlate with the covariance between cell numbers and module expression in human blood and tissue samples...
2017: PloS One
https://www.readbyqxmd.com/read/28040731/quantifying-the-extent-to-which-index-event-biases-influence-large-genetic-association-studies
#14
Hanieh Yaghootkar, Michael P Bancks, Sam E Jones, Aaron McDaid, Robin Beaumont, Louise Donnelly, Andrew R Wood, Archie Campbell, Jessica Tyrrell, Lynne J Hocking, Marcus A Tuke, Katherine S Ruth, Ewan R Pearson, Anna Murray, Rachel M Freathy, Patricia B Munroe, Caroline Hayward, Colin Palmer, Michael N Weedon, James S Pankow, Timothy M Frayling, Zoltán Kutalik
As genetic association studies increase in size to 100,000s of individuals, subtle biases may influence conclusions. One possible bias is "index event bias" (IEB) that appears due to the stratification by, or enrichment for, disease status when testing associations between genetic variants and a disease-associated trait. We aimed to test the extent to which IEB influences some known trait associations in a range of study designs and provide a statistical framework for assessing future associations. Analysing data from 113,203 non-diabetic UK Biobank participants, we observed three (near TCF7L2, CDKN2AB and CDKAL1) overestimated (BMI-decreasing) and one (near MTNR1B) underestimated (BMI-increasing) associations among 11 type 2 diabetes risk alleles (at P < 0...
December 30, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28032123/ten-year-patient-reported-outcomes-following-total-and-minimally-invasive-unicompartmental-knee-arthroplasty-a-propensity-score-matched-cohort-analysis
#15
Edward Burn, Maria T Sanchez-Santos, Hemant G Pandit, Thomas W Hamilton, Alexander D Liddle, David W Murray, Rafael Pinedo-Villanueva
PURPOSE: For patients with medial compartment arthritis who have failed non-operative treatment, either a total knee arthroplasty (TKA) or a unicompartmental knee arthroplasty (UKA) can be undertaken. This analysis considers how the choice between UKA and TKA affects long-term patient-reported outcome measures (PROMs). METHODS: The Knee Arthroplasty Trial (KAT) and a cohort of patients who received a minimally invasive UKA provided data. Propensity score matching was used to identify comparable patients...
December 29, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28005955/vegetation-productivity-in-natural-vs-cultivated-systems-along-water-availability-gradients-in-the-dry-subtropics
#16
Germán Baldi, Marcos Texeira, Francisco Murray, Esteban G Jobbágy
The dry subtropics are subject to a rapid expansion of crops and pastures over vast areas of natural woodlands and savannas. In this paper, we explored the effect of this transformation on vegetation productivity (magnitude, and seasonal and long-term variability) along aridity gradients which span from semiarid to subhumid conditions, considering exclusively those areas with summer rains (>66%). Vegetation productivity was characterized with the proxy metric "Enhanced Vegetation Index" (EVI) (2000 to 2012 period), on 6186 natural and cultivated sampling points on five continents, and combined with a global climatology database by means of additive models for quantile regressions...
2016: PloS One
https://www.readbyqxmd.com/read/28005867/ultrafast-laser-plasma-doping-of-er-sup-3-sup-ions-in-silica-on-silicon-for-optical-waveguiding-applications
#17
Suraya Ahmad Kamil, Jayakrishnan Chandrappan, Matthew Murray, Paul Steenson, Thomas F Krauss, Gin Jose
An ultrafast laser plasma doping (ULPD) technique is used for high concentration doping of erbium ions into silica-on-silicon substrate. The method uses a femtosecond laser to ablate material from TeO<sub>2</sub>-ZnO-Na<sub>2</sub>O-Er<sub>2</sub>O<sub>3</sub> (Er-TZN) target glass. The laser-generated plasma modifies the silica network, producing a high-index-contrast optical layer suited to the production of on-chip integrated optical circuits. Cross-sectional analysis using scanning electron microscope with energy dispersive x-ray spectroscopy revealed homogeneous intermixing of the host silica with Er-TZN, which is unique to ULPD...
October 15, 2016: Optics Letters
https://www.readbyqxmd.com/read/27987022/long-term-outcomes-of-intravesical-dimethyl-sulfoxide-heparin-hydrocortisone-therapy-for-interstitial-cystitis-bladder-pain-syndrome
#18
Yik N Lim, Peter Dwyer, Christine Murray, Debjyoti Karmakar, Anna Rosamilia, Elizabeth Thomas
INTRODUCTION AND HYPOTHESIS: For decades, intravesical dimethyl sulfoxide (DMSO) cocktail therapy has been used for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS), but little is known about its long-term efficacy. We aimed to assess the long-term efficacy of intravesical DMSO/heparin/hydrocortisone/bupivacaine therapy in patients with IC/BPS. METHODS: Patients with IC/BPS from our institutions who underwent this therapy with >2 years follow-up were surveyed with O'Leary-Sant interstitial cystitis symptom and problem index questionnaires before and after therapy...
December 16, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27986593/modeling-emissions-from-cafo-poultry-farms-in-poland-and-evaluating-potential-risk-to-surrounding-populations
#19
H R Pohl, M Citra, H A Abadin, I Szadkowska-Stańczyk, A Kozajda, L Ingerman, A Nguyen, H E Murray
The world-wide use of concentrated animal feeding operations (CAFOs) for livestock production demands the need to evaluate the potential impact to public health. We estimated the exposure of various airborne pollutants for populations residing in close proximity to 10 poultry CAFOs located in Central Poland. Ammonia (NH3), carbon dioxide (CO2), carbon monoxide (CO), hydrogen sulfide (H2S), methane (CH4), nitrogen dioxide (NO2), nitrous oxide (N2O), sulfur dioxide (SO2), and organic dust were the pollutants of interest for this study...
December 13, 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27932489/psychometric-properties-of-the-irish-management-standards-indicator-tool
#20
S Boyd, R Kerr, P Murray
BACKGROUND: Work Positive is Ireland's national policy initiative to control work-related stress. Since the introduction of the UK Health and Safety Executive's Management Standards (MS) in 2004, a number of studies have been undertaken to assess the potential adaptation of the MS framework within Ireland. AIMS: To investigate the dimensionality, reliability and validity of the Irish version of the MS Indicator Tool (ROI-MSIT). METHODS: Between February 2011 and June 2014, we collected data from a wide range of public and private sector organizations that used the ROI-MSIT...
December 2016: Occupational Medicine
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