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https://www.readbyqxmd.com/read/29223883/analysis-of-mainland-japanese-and-okinawan-japanese-populations-using-the-precision-id-ancestry-panel
#1
Hiroaki Nakanishi, Vania Pereira, Claus Børsting, Toshimichi Yamamoto, Torben Tvedebrink, Masaaki Hara, Aya Takada, Kazuyuki Saito, Niels Morling
We typed 165 AIMs in 49 mainland Japanese and 47 Okinawa Japanese using the Precision ID Ancestry Panel (Thermo Fisher Scientific). None of the 165 SNPs showed significant deviation from Hardy-Weinberg equilibrium in the mainland Japanese. One SNP (rs3943253) showed significant deviation from Hardy-Weinberg equilibrium in Okinawa Japanese. Fisher's exact tests showed that the genotype frequencies of 14 loci were significantly different (p<0.05) between the two populations before correction for multiple testing...
December 6, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29222064/evolution-in-the-amphi-atlantic-tropical-genus-guibourtia-fabaceae-detarioideae-combining-ngs-phylogeny-and-morphology
#2
Félicien Tosso, Olivier J Hardy, Jean-Louis Doucet, Kasso Daïnou, Esra Kaymak, Jérémy Migliore
Tropical rain forests support a remarkable diversity of tree species, questioning how and when this diversity arose. The genus Guibourtia (Fabaceae, Detarioideae), characterized by two South American and 13 African tree species growing in various tropical biomes, is an interesting model to address the role of biogeographic processes and adaptation to contrasted environments on species diversification. Combining whole plastid genome sequencing and morphological characters analysis, we studied the timing of speciation and diversification processes in Guibourtia through molecular dating and ancestral habitats reconstruction...
December 5, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29221741/balloon-expandable-transaortic-transcatheter-aortic-valve-implantation-with-or-without-predilation
#3
Nikolaos Bonaros, Markus Kofler, Derk Frank, Riccardo Cocchieri, Dariusz Jagielak, Marco Aiello, Joel Lapeze, Mika Laine, Sidney Chocron, Douglas Muir, Walter Eichinger, Matthias Thielmann, Louis Labrousse, Vinayak Bapat, Kjell Arne Rein, Jean-Philippe Verhoye, Gino Gerosa, Hardy Baumbach, Cornelia Deutsch, Peter Bramlage, Martin Thoenes, Mauro Romano
OBJECTIVE: It has been reported that balloon aortic valvuloplasty immediately before transfemoral or transapical transcatheter aortic valve implantation has mostly little to no clinical value. We aimed to provide data on the need for balloon aortic valvuloplasty in patients undergoing transaortic transcatheter aortic valve implantation. METHODS: Patients undergoing transaortic transcatheter aortic valve implantation with the Edwards SAPIEN XT (Nyon, Switzerland) or 3 transcatheter heart valve were prospectively included at 18 sites across Europe...
November 2, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29221218/tert-rs2736098-ex2-659g-a-polymorphism-and-cancer-susceptibility-evidence-from-a-comprehensive-meta-analysis
#4
Tingyuan Pang, Minjie Zhou, Rumin Liu, Jia Luo, Renfei Xia
Increasing researches have been performed regarding the relationship between TERT rs2736098 and cancer risk, but no consensus has been reached about the relationship. Here, we conducted this updated meta-analysis, aiming to comprehensively evaluate the role of TERT rs2736098 in cancer risk. We systematically searched potential relevant articles through PubMed, EMBASE, CNKI, and WanFang database before August 2017. A total of 33 studies with 18685 cases and 23820 controls were finally included in the current meta-analysis...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221106/high-sensitivity-optical-biosensor-based-on-polymer-materials-and-using-the-vernier-effect
#5
Paul Azuelos, Pauline Girault, Nathalie Lorrain, Luiz Poffo, Mohammed Guendouz, Monique Thual, Jonathan Lemaître, Parastesh Pirasteh, Isabelle Hardy, Joël Charrier
We demonstrate the fabrication of a Vernier effect SU8/PMATRIFE polymer optical biosensor with high homogeneous sensitivity using a standard photolithography process. The sensor is based on one micro-resonator embedded on each arm of a Mach-Zehnder interferometer. Measurements are based on the refractive index variation of the optical waveguide superstrate with different concentrations of glucose solutions. The sensitivity of the sensor has been measured as 17558 nm/RIU and the limit of detection has been estimated to 1...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29219243/genetic-polymorphism-of-human-leucocyte-antigen-and-susceptibility-to-multidrug-resistant-and-rifampicin-resistant-tuberculosis-in-han-chinese-from-hubei-province
#6
X Zhou, Q Zhou, Z-F Yang, W-X Li
We determined the high-resolution allele and haplotype frequencies at the human leucocyte antigen (HLA)A, B and DRB1 loci in the Han population of Hubei province, the TB endemic area of Central China, with pulmonary tuberculosis (PTB), and established the relationship between HLA-A, B and DRB1 alleles as well as haplotypes and susceptibility to multidrug-resistant and rifampicin-resistant tuberculosis (MDR/RR-TB). Blood samples were drawn from 174 patients with MDR/RR-TB and 838 patients with drug-susceptible PTB in ethnic Han population from Hubei province (central China)...
December 8, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29217570/a-precise-measurement-of-the-magnetic-field-in-the-corona-of-the-black-hole-binary-v404-cygni
#7
Yigit Dallilar, Stephen S Eikenberry, Alan Garner, Richard D Stelter, Amy Gottlieb, Poshak Gandhi, Piergiorgio Casella, Vik S Dhillon, Tom R Marsh, Stuart P Littlefair, Liam Hardy, Rob Fender, Kunal Mooley, Dominic J Walton, Felix Fuerst, Matteo Bachetti, A J Castro-Tirado, Miguel Charcos, Michelle L Edwards, Nestor M Lasso-Cabrera, Antonio Marin-Franch, S Nicholas Raines, Kendall Ackley, John G Bennett, A Javier Cenarro, Brian Chinn, H Veronica Donoso, Raymond Frommeyer, Kevin Hanna, Michael D Herlevich, Jeff Julian, Paola Miller, Scott Mullin, Charles H Murphey, Chris Packham, Frank Varosi, Claudia Vega, Craig Warner, A N Ramaprakash, Mahesh Burse, Sujit Punnadi, Pravin Chordia, Andreas Gerarts, Héctor de Paz Martín, María Martín Calero, Riccardo Scarpa, Sergio Fernandez Acosta, William Miguel Hernández Sánchez, Benjamin Siegel, Francisco Francisco Pérez, Himar D Viera Martín, José A Rodríguez Losada, Agustín Nuñez, Álvaro Tejero, Carlos E Martín González, César Cabrera Rodríguez, Jordi Molgó, J Esteban Rodriguez, J Israel Fernández Cáceres, Luis A Rodríguez García, Manuel Huertas Lopez, Raul Dominguez, Tim Gaggstatter, Antonio Cabrera Lavers, Stefan Geier, Peter Pessev, Ata Sarajedini
Observations of binary stars containing an accreting black hole or neutron star often show x-ray emission extending to high energies (>10 kilo--electron volts), which is ascribed to an accretion disk corona of energetic particles akin to those seen in the solar corona. Despite their ubiquity, the physical conditions in accretion disk coronae remain poorly constrained. Using simultaneous infrared, optical, x-ray, and radio observations of the Galactic black hole system V404 Cygni, showing a rapid synchrotron cooling event in its 2015 outburst, we present a precise 461 ± 12 gauss magnetic field measurement in the corona...
December 8, 2017: Science
https://www.readbyqxmd.com/read/29215544/the-251-a-t-polymorphism-in-the-il8-promoter-is-a-risk-factor-for-acute-pancreatitis
#8
Shrinivas Bishu, Efstratios Koutroumpakis, Rawad Mounzer, Kimberly Stello, Nijole Pollock, Anna Evans, David C Whitcomb, Georgios I Papachristou
OBJECTIVES: Inflammation in the setting of acute pancreatitis (AP) is partially driven by pathogen recognition receptors that recognize damage-associated molecular patterns. Interleukin (IL)-8 is a chemotactic factor produced by pathogen recognition receptor-expressing cells. A single-nucleotide polymorphism in IL8 promoter region (-251 A/T) has been implicated in inflammatory diseases. We examined whether this IL8 polymorphism confers susceptibility to AP. METHODS: Patients with AP (n = 357) were prospectively recruited...
December 5, 2017: Pancreas
https://www.readbyqxmd.com/read/29215385/restless-legs-syndrome-and-schizophrenia-a-case-report
#9
Romain Colle, Flavien Boichot, Erwan Bouteiller, Céline Elie-Lefebvre, Patrick Hardy, Denis J David, Céline Verstuyft, Emmanuelle Corruble
No abstract text is available yet for this article.
December 6, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29215009/the-end-joining-factor-ku-acts-in-the-end-resection-of-double-strand-break-free-arrested-replication-forks
#10
Ana Teixeira-Silva, Anissia Ait Saada, Julien Hardy, Ismail Iraqui, Marina Charlotte Nocente, Karine Fréon, Sarah A E Lambert
Replication requires homologous recombination (HR) to stabilize and restart terminally arrested forks. HR-mediated fork processing requires single stranded DNA (ssDNA) gaps and not necessarily double strand breaks. We used genetic and molecular assays to investigate fork-resection and restart at dysfunctional, unbroken forks in Schizosaccharomyces pombe. Here, we report that fork-resection is a two-step process regulated by the non-homologous end joining factor Ku. An initial resection mediated by MRN-Ctp1 removes Ku from terminally arrested forks, generating ~110 bp sized gaps obligatory for subsequent Exo1-mediated long-range resection and replication restart...
December 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29214852/factor-structure-of-the-brief-comprehensive-effects-of-alcohol-scale-in-adolescents
#11
Lindsay S Ham, Byron L Zamboanga, Alan Meca, Heidemarie Blumenthal, Sam A Hardy, Lauren E Hurd
Alcohol use among adolescents is a public health concern; therefore, it is important that studies that examine factors associated with adolescent drinking behaviors utilize measures that are well-validated for use with this population. The current study examined the factor structure and convergent validity of the Brief Comprehensive Effects of Alcohol scale, a measure of alcohol outcome expectancies and evaluations of expected outcomes, among adolescents ( N = 1,074; 50% girls; Mage = 15.96 years, SD = 1.13, range = 13-18; 74% White) drawn from three independent studies ( nsite 1 = 594; nsite 2 = 97; and nsite 3 = 383)...
March 1, 2017: Assessment
https://www.readbyqxmd.com/read/29212704/performance-of-ceftolozane-tazobactam-etest-mic-test-strips-and-disk-diffusion-as-compared-to-reference-broth-microdilution-for-beta-lactam-resistant-pseudomonas-aeruginosa-isolates
#12
Romney M Humphries, Janet A Hindler, Paul Magnano, Annie Wong-Beringer, Robert Tibbetts, Shelley A Miller
The performance of ceftolozane-tazobactam Etest (bioMerieux, Marcy L'Etoile, France), MIC Test Strips (MTS, Liofilchem, Italy) and disk diffusion (Hardy, Santa Ana, CA) were evaluated for a collection of 308 beta-lactam resistant isolates of Pseudomonas aeruginosa recovered from three institutions in Los Angeles, CA. Reference testing was performed by reference broth microdilution (rBMD). MIC and disk results were interpreted using Clinical and Laboratory Standards Institute breakpoints. Overall, 72.5% of isolates were susceptible to C/T by rBMD...
December 6, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29209924/treatment-of-sporadic-burkitt-lymphoma-in-adults-a-retrospective-comparison-of-four-treatment-regimens
#13
L E M Oosten, M E D Chamuleau, F W Thielen, L C de Wreede, C Siemes, J K Doorduijn, O S Smeekes, M J Kersten, L Hardi, J W Baars, A M P Demandt, W B C Stevens, M Nijland, G W van Imhoff, R Brouwer, C A Uyl-de Groot, P M Kluin, D de Jong, H Veelken
Burkitt lymphoma is an aggressive B cell malignancy accounting for 1-2% of all adult lymphomas. Treatment with dose-intensive, multi-agent chemotherapy is effective but associated with considerable toxicity. In this observational study, we compared real-world efficacy, toxicity, and costs of four frequently employed treatment strategies for Burkitt lymphoma: the Lymphome Malins B (LMB), the Berlin-Frankfurt-Münster (BFM), the HOVON, and the CODOX-M/IVAC regimens. We collected data from 147 adult patients treated in eight referral centers...
December 6, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29209506/border-terriers-under-primary-veterinary-care-in-england-demography-and-disorders
#14
Dan G O'Neill, Elisabeth C Darwent, David B Church, Dave C Brodbelt
Background: The Border Terrier is a working terrier type that is generally considered to be a relatively healthy and hardy breed. This study aimed to characterise the demography and common disorders of Border Terriers receiving veterinary care in England using de-identified electronic patient record data within the VetCompass™ Programme. Results: Annual birth proportion for Border Terriers showed a decreasing trend from 1.46% in 2005 to 0.78% in 2014. The median adult bodyweight for males (10...
2017: Canine Genetics and Epidemiology
https://www.readbyqxmd.com/read/29209099/polymorphisms-in-ccr5%C3%AE-32-and-risk-of-hiv-1-infection-in-the-southeast-of-caspian-sea-iran
#15
Zahra Heydarifard, Alijan Tabarraei, Abdolvahab Moradi
Prevalence of CCR5Δ32 among blood samples of more than 400 healthy and HIV-1-infected people was investigated in Iran. Polymerase chain reaction (PCR) following DNA extraction was used. Desired frequency was analyzed by Hardy-Weinberg equilibrium (HWE) analysis and SPSS 16.0 software to harvest the results. The prevalence of CCRΔ32 heterozygote genotype was 3% in healthy people and 0.7% in HIV-1-infected individuals. There was no homozygote CCR5Δ32 in both groups, and the allele Δ32 was only observed in 1...
2017: Disease Markers
https://www.readbyqxmd.com/read/29208477/impact-of-opioid-therapy-on-sleep-and-respiratory-patterns-in-adults-with-advanced-cancer-receiving-palliative-care
#16
Phillip Good, Ross Pinkerton, Simon Bowler, Justin Craig, Janet Hardy
CONTEXT: In advanced cancer, abnormal sleep patterns may contribute to poor quality of life but the impact of opioid related sleep disorders has not been explored in detail in these patients. OBJECTIVE: To document sleep and respiratory patterns in patients with cancer, receiving a range of opioids, determine factors that contribute to severity of central or obstructive apnoea and to what extent these contribute to sleep disturbance. METHODS: Adults with advanced cancer admitted to a palliative care service underwent a sleep analysis by an unattended polysomnograph...
December 2, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29206944/the-direct-and-indirect-effects-of-kisspeptin-54-on-granulosa-lutein-cell-function
#17
L A Owens, A Abbara, A Lerner, S O'floinn, G Christopoulos, S Khanjani, R Islam, K Hardy, A C Hanyaloglu, S A Lavery, W S Dhillo, S Franks
STUDY QUESTION: What are the in vivo and in vitro actions of kisspeptin-54 on the expression of genes involved in ovarian reproductive function, steroidogenesis and ovarian hyperstimulation syndrome (OHSS) in granulosa lutein (GL) cells when compared with traditional triggers of oocyte maturation? SUMMARY ANSWER: The use of kisspeptin-54 as an oocyte maturation trigger augmented expression of genes involved in ovarian steroidogenesis in human GL cells including, FSH receptor (FSHR), LH/hCG receptor (LHCGR), steroid acute regulatory protein (STAR), aromatase, estrogen receptors alpha and beta (ESR1, ESR2), 3-beta-hydroxysteroid dehydrogenase type 2 (3BHSD2) and inhibin A (INHBA), when compared to traditional maturation triggers, but did not alter markers of OHSS...
December 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29202709/transcriptomic-and-metabolic-responses-of-calotropis-procera-to-salt-and-drought-stress
#18
Mohammed Z Mutwakil, Nahid H Hajrah, Ahmed Atef, Sherif Edris, Mernan J Sabir, Areej K Al-Ghamdi, Meshaal J S M Sabir, Charlotte Nelson, Rania M Makki, Hani M Ali, Fotouh M El-Domyati, Abdulrahman S M Al-Hajar, Yoann Gloaguen, Hassan S Al-Zahrani, Jamal S M Sabir, Robert K Jansen, Ahmed Bahieldin, Neil Hall
BACKGROUND: Calotropis procera is a wild plant species in the family Apocynaceae that is able to grow in harsh, arid and heat stressed conditions. Understanding how this highly adapted plant persists in harsh environments should inform future efforts to improve the hardiness of crop and forage plant species. To study the plant response to droμght and osmotic stress, we treated plants with polyethylene glycol and NaCl and carried out transcriptomic and metabolomics measurements across a time-course of five days...
December 4, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29201279/mapping-age-effects-along-fiber-tracts-in-young-adults
#19
Emily L Dennis, Faisal Rashid, Josh Faskowitz, Yan Jin, Katie L McMahon, Greig I de Zubicaray, Nicholas G Martin, Ian B Hickie, Margaret J Wright, Neda Jahanshad, Paul M Thompson
Brain development is a protracted and dynamic process. Many studies have charted the trajectory of white matter development, but here we sought to map these effects in greater detail, based on a large set of fiber tracts automatically extracted from HARDI (high angular resolution diffusion imaging) at 4 tesla. We used autoMATE (automated multi-atlas tract extraction) to extract diffusivity measures along 18 of the brain's major fiber bundles in 667 young adults, aged 18-30. We examined linear and non-linear age effects on diffusivity measures, pointwise along tracts...
2017: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
https://www.readbyqxmd.com/read/29201014/impaired-interoceptive-accuracy-in-semantic-variant-primary-progressive-aphasia
#20
Charles R Marshall, Chris J D Hardy, Lucy L Russell, Camilla N Clark, Katrina M Dick, Emilie V Brotherhood, Rebecca L Bond, Catherine J Mummery, Jonathan M Schott, Jonathan D Rohrer, James M Kilner, Jason D Warren
Background: Interoception (the perception of internal bodily sensations) is strongly linked to emotional experience and sensitivity to the emotions of others in healthy subjects. Interoceptive impairment may contribute to the profound socioemotional symptoms that characterize frontotemporal dementia (FTD) syndromes, but remains poorly defined. Methods: Patients representing all major FTD syndromes and healthy age-matched controls performed a heartbeat counting task as a measure of interoceptive accuracy...
2017: Frontiers in Neurology
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