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https://www.readbyqxmd.com/read/29034839/pharmacogenetics-of-angiotensin-converting-enzyme-inhibitors-in-patients-with-alzheimer-s-disease-dementia
#1
Fabricio Ferreira de Oliveira, Elizabeth Suchi Chen, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucci
BACKGROUND: While the angiotensin-converting enzyme degrades amyloid-β, angiotensin-converting enzyme inhibitors (ACEis) may slow cognitive decline by way of cholinergic effects, by increasing brain substance P and boosting the activity of neprilysin, and by modulating glucose homeostasis and augmenting the secretion of adipokines to enhance insulin sensitivity in patients with Alzheimer's disease dementia (AD). We aimed to investigate whether ACE gene polymorphisms rs1800764 and rs4291 are associated with cognitive and functional change in patients with AD, while also taking APOE haplotypes and anti-hypertensive treatment with ACEis into account for stratification...
October 16, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29034107/high-throughput-testing-of-urogenital-and-extragenital-specimens-for-detection-of-chlamydia-trachomatis-and-neisseria-gonorrhoeae-with-cobas-%C3%A2-ct-ng
#2
Elizabeth M Marlowe, David Hardy, Mark Krevolin, Peter Gohl, Alexander Bertram, Rodney Arcenas, Britta Seiverth, Tanja Schneider, Oliver Liesenfeld
We compared the analytical and clinical performance of cobas(®) CT/NG for use on the Cobas(®) 6800/8800 Systems with the Cobas(®) 4800 CT/NG Test from urogenital and extragenital specimens in over 12,000 specimens from both male and female subjects in Germany and the United States. The analytical sensitivity was ≤40 EB/ml for Chlamydia trachomatis (CT) and ≤1 CFU/ml for Neisseria gonorrhoeae (NG). Using clinical specimens, the overall percent agreement with the Cobas(®) 4800 CT/NG Test was >98.5%...
September 2017: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/29034085/amp-activated-protein-kinase-not-just-an-energy-sensor
#3
REVIEW
David Grahame Hardie, Sheng-Cai Lin
Orthologues of AMP-activated protein kinase (AMPK) occur in essentially all eukaryotes as heterotrimeric complexes comprising catalytic α subunits and regulatory β and γ subunits. The canonical role of AMPK is as an energy sensor, monitoring levels of the nucleotides AMP, ADP, and ATP that bind competitively to the γ subunit. Once activated, AMPK acts to restore energy homeostasis by switching on alternate ATP-generating catabolic pathways while switching off ATP-consuming anabolic pathways. However, its ancestral role in unicellular eukaryotes may have been in sensing of glucose rather than energy...
2017: F1000Research
https://www.readbyqxmd.com/read/29033236/pharmaconutrition-with-intravenous-selenium-in-intensive-care-the-end-of-an-era
#4
Pascal L Langlois, Gil Hardy, William Manzanares
No abstract text is available yet for this article.
August 5, 2017: Nutrition
https://www.readbyqxmd.com/read/29032489/away-from-the-islands-diaspora-s-effects-on-native-hawaiian-elders-and-families-in-california
#5
Colette V Browne, Kathryn L Braun
Native Hawaiians, the indigenous people of Hawai'i, were once a healthy and hardy people. But today they are affected by varying social and health disparities that have led to poor social and health outcomes. Most of the research on Hawaiians in general and Native Hawaiian elders in particular has been conducted in Hawai'i, even though the Hawaiian Diaspora has resulted in 45% of this population residing in North America and Alaska. This qualitative study used key informant interviews and focus group methods to examine reasons for migration and perspectives on aging and caregiving in a sample of Native Hawaiian elders and family caregivers residing in Southern California...
October 14, 2017: Journal of Cross-cultural Gerontology
https://www.readbyqxmd.com/read/29032382/angiotensin-converting-enzyme-gene-deletion-polymorphism-is-associated-with-lymph-node-metastasis-in-colorectal-cancer-patients-in-a-chinese-population
#6
Xiao Zheng, Guoli Liu, Gang Cui, Ming Cheng, Nan Zhang, Sanyuan Hu
BACKGROUND The purpose of this study was to assess the effect of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism on the risk of lymph node metastasis (LNM) in colorectal cancer (CRC) patients. MATERIAL AND METHODS We enrolled 146 CRC patients and 106 healthy controls in this study. ACE gene I/D polymorphism was genotyped by polymerase chain reaction (PCR). Hardy-Weinberg equilibrium (HWE) was used to assess the goodness of fit of the genotypes. χ² test was used to calculate the differences of genotype and allele distributions...
October 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29030787/armillifer-infected-snakes-sold-at-congolese-bushmeat-markets-represent-an-emerging-zoonotic-threat
#7
Richard Hardi, Gergely Babocsay, Dennis Tappe, Mihály Sulyok, Imre Bodó, Lajos Rózsa
African pythons (Pythonidae) and large vipers (Bitis spp.) act as definitive hosts for Armillifer armillatus and Armillifer grandis parasites (Crustacea: Pentastomida) in the Congo Basin. Since the proportion of snakes in bushmeat gradually increases, human pentastomiasis is an emerging zoonotic disease. To substantiate the significance of this threat, we surveyed snakes offered for human consumption at bushmeat markets in the Kole district, Democratic Republic of the Congo, for the presence of adult pentastomids...
October 13, 2017: EcoHealth
https://www.readbyqxmd.com/read/29029081/rapid-cold-hardening-of-a-subtropical-species-maruca-vitrata-lepidoptera-crambidae-accompanies-hypertrehalosemia-by-upregulating-trehalose-6-phosphate-synthase
#8
Yonggyun Kim, Dae-Weon Lee, Jin Kyo Jung
A subtropical insect, Maruca vitrata (F.) (Lepidoptera: Crambidae), is invasive to temperate zones, in which low temperatures during winter would be a serious challenge for colonization. This study assessed cold tolerance and cold-hardening of M. vitrata to understand its overwintering mechanism. Supercooling capacity was confirmed in all developmental stages exhibiting body freezing points at lower than -10°C, in which supercooling points (SCPs) were significantly different among developmental stages, with eggs having the lowest SCP (at -22...
September 23, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29028996/cold-tolerance-of-megacopta-cribraria-hemiptera-plataspidae-an-invasive-pest-of-soybeans
#9
Jessica I Grant, William O Lamp
Kudzu bug, Megacopta cribraria Fabricius (Hemiptera: Plataspidae), first discovered in the United States in 2009, is an invasive pest of soybeans. From 2013 to 2016, Maryland has been the northern limit of its distribution in the United States. We sought to determine the physiological cold temperature limits, timing of movement to overwintering locations, and to characterize overwintering microhabitat temperature. We measured supercooling point (SCP) on three populations from distinct USDA plant hardiness zones in Maryland and Virginia between October and December of 2015...
September 23, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29026500/effectiveness-of-resilience-training-on-ego-control-and-hardiness-of-illicit-drug-users
#10
Amin Roustaei, Babollah Bakhshipoor, Younes Doostian, Ali Akbar Goodiny, Mansoureh Koohikar, Omid Massah
BACKGROUND: The aim of this research was to determine the effectiveness of resilience training upon ego-control and hardiness of the addicted persons. METHODS: This was a semi-experimental study with pretest and posttest control groups which was conducted in Sari, Iran, during 2014-2015. Thirty persons were selected among 240 illicit drug users who underwent screening. Resilience training was performed in ten sessions for the experimental group. The Kobasa hardiness questionnaire and self-restraint scale (SRS) were used for data collection and multivariate covariance test was performed for data analysis...
January 2017: Addiction & Health
https://www.readbyqxmd.com/read/29026114/the-driver-landscape-of-sporadic-chordoma
#11
Patrick S Tarpey, Sam Behjati, Matthew D Young, Inigo Martincorena, Ludmil B Alexandrov, Sarah J Farndon, Charlotte Guzzo, Claire Hardy, Calli Latimer, Adam P Butler, Jon W Teague, Adam Shlien, P Andrew Futreal, Sohrab Shah, Ali Bashashati, Farzad Jamshidi, Torsten O Nielsen, David Huntsman, Daniel Baumhoer, Sebastian Brandner, Jay Wunder, Brendan Dickson, Patricia Cogswell, Josh Sommer, Joanna J Phillips, M Fernanda Amary, Roberto Tirabosco, Nischalan Pillay, Stephen Yip, Michael R Stratton, Adrienne M Flanagan, Peter J Campbell
Chordoma is a malignant, often incurable bone tumour showing notochordal differentiation. Here, we defined the somatic driver landscape of 104 cases of sporadic chordoma. We reveal somatic duplications of the notochordal transcription factor brachyury (T) in up to 27% of cases. These variants recapitulate the rearrangement architecture of the pathogenic germline duplications of T that underlie familial chordoma. In addition, we find potentially clinically actionable PI3K signalling mutations in 16% of cases...
October 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29025103/commentary-intrauterine-exposure-to-artificially-sweetened-beverages-and-offspring-adiposity-is-this-the-tip-of-the-iceberg
#12
Louise L Hardy
No abstract text is available yet for this article.
September 12, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29023224/zebrafish-a-premier-vertebrate-model-for-biomedical-research-in-indian-scenario
#13
Sreeja Sarasamma, Muhammed Muhsin Varikkodan, Sung-Tzu Liang, Yen-Chang Lin, Wen-Pin Wang, Chung-Der Hsiao
The zebrafish (Danio rerio) is a versatile model organism that has been used in biomedical research for several decades to study a wide range of biological phenomena. There are many technical advantages of using zebrafish over other vertebrate models. They are readily available, hardy, easy, and inexpensive to maintain in the laboratory, have a short life cycle, and have excellent fecundity. Due to its optical clarity and reproducible capabilities, it has become one of the predominant models of human genetic diseases...
October 12, 2017: Zebrafish
https://www.readbyqxmd.com/read/29022010/the-effect-of-cold-acclimation-on-the-low-molecular-weight-carbohydrate-composition-of-safflower
#14
Erik J Landry, Sam J Fuchs, Vicki L Bradley, R C Johnson
Understanding cold acclimation and identifying the low molecular weight carbohydrates that support the development of freezing tolerant safflower seedlings will aid in breeding winter-hardy cultivars for temperate cropping systems. Three field selected lines of winter safflower (WSRC01: PI 651878; WSRC02: PI 651879; WSRC03: PI 651880) were cold acclimated for four weeks at 4 °C and compared to seedlings grown for two weeks at 20 °C. The commercial spring-type cultivar, Olé, served as a non-hardy check. Leaf, stem, and root fructose, glucose, sucrose, raffinose, and stachyose concentrations all increased to variable extents across the PI accessions after cold acclimation...
September 2017: Heliyon
https://www.readbyqxmd.com/read/29021894/occupational-stress-and-the-importance-of-self-care-and-resilience-focus-on-veterinary-nursing
#15
REVIEW
Ciaran Lloyd, Deirdre P Campion
BACKGROUND: Burnout and compassion fatigue are frequently mentioned in relation to veterinary work. Veterinary nursing is a caring profession and those who seek a career within this field do so because of a natural empathetic desire to care for animals. However it is the individuals who are the most caring and empathetic towards others that will be most at risk of experiencing occupational stress when they are confronted with psychologically demanding workplace roles and working environments...
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/29020976/the-added-value-of-a-mobile-application-of-community-case-management-on-referral-re-consultation-and-hospitalization-rates%C3%A2-of-children-aged-under-5-years-in-two-districts-in-northern-malawi-study-protocol-for-a-pragmatic-stepped-wedge-cluster-randomized-controlled
#16
Victoria Hardy, Yvonne O'Connor, Ciara Heavin, Nikolaos Mastellos, Tammy Tran, John O'Donoghue, Annette L Fitzpatrick, Nicole Ide, Tsung-Shu Joseph Wu, Griphin Baxter Chirambo, Adamson S Muula, Moffat Nyirenda, Sven Carlsson, Bo Andersson, Matthew Thompson
BACKGROUND: There is evidence to suggest that frontline community health workers in Malawi are under-referring children to higher-level facilities. Integrating a digitized version of paper-based methods of Community Case Management (CCM) could strengthen delivery, increasing urgent referral rates and preventing unnecessary re-consultations and hospital admissions. This trial aims to evaluate the added value of the Supporting LIFE electronic Community Case Management Application (SL eCCM App) compared to paper-based CCM on urgent referral, re-consultation and hospitalization rates, in two districts in Northern Malawi...
October 11, 2017: Trials
https://www.readbyqxmd.com/read/29020448/preparation-of-tc99m-labeled-pseudomonas-bacteriophage-without-adversely-impacting-infectivity-or-biodistribution
#17
Derek Holman, Matthew P Lungren, Jonathan Hardy, Christopher H Contag, Francis G Blankenberg
Bacteriophages (phages) are ubiquitous viruses which have adapted to infect and replicate within target bacteria, their only known hosts, in a strain specific fashion with minimal cross infectivity. The recent steep rise in antibiotic resistance throughout the world has renewed interest in adapting phages for the imaging and treatment of bacterial infection in humans. In this article, we describe the current limitations surrounding the radiolabeling of phage for the imaging and treatment of bacterial infection and methods to overcome these difficulties...
October 11, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29020397/pentraxin-3-gene-polymorphisms-and-pulmonary-aspergillosis-in-copd-patients
#18
Qian He, Hongxing Li, Yuwen Rui, Lulu Liu, Binchan He, Yi Shi, Xin Su
Background: Pentraxin 3 (PTX3) plays an important role in resistance to Aspergillus infections. Previous studies have suggested that PTX3 polymorphisms influence the risk of invasive aspergillosis among transplantation recipients. This study was to investigate the association between PTX3 gene polymorphisms and pulmonary aspergillosis in chronic obstructive pulmonary disease (COPD) population. Methods: We included 173 consecutive inpatients with COPD. 36 cases were finally diagnosed with pulmonary aspergillosis...
August 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29019990/genetics-of-a-hardy-crop
#19
Ksenia V Krasileva
No abstract text is available yet for this article.
October 11, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/29018763/ocular-manifestations-of-sickle-cell-disease-and-genetic-susceptibility-for-refractive-errors
#20
Palak Shukla, Henu Verma, Santosh Patel, P K Patra, L V K S Bhaskar
PURPOSE: Sickle cell disease (SCD) is the most common and serious form of an inherited blood disorder that lead to higher risk of early mortality. SCD patients are at high risk for developing multiorgan acute and chronic complications linked with significant morbidity and mortality. Some of the ophthalmological complications of SCD include retinal changes, refractive errors, vitreous hemorrhage, and abnormalities of the cornea. MATERIALS AND METHODS: The present study includes 96 SCD patients...
April 2017: Taiwan Journal of Ophthalmology
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