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https://www.readbyqxmd.com/read/28535265/physiology-of-cold-hardiness-seasonal-fluctuations-and-cryoprotectant-contents-in-overwintering-adults-of-hypera-postica-coleoptera-curculionidae
#1
Mahdieh Saeidi, Saeid Moharramipour
The alfalfa weevil, Hypera postica (Gyllenhal), is widely distributed in various alfalfa-growing regions in the world. Adults enter the field gradually from hibernation places and overwinter in a nondiapausing state, exhibiting feeding, mating, and oviposition over autumn and winter whenever the weather permits. In this study, the variability of supercooling point (SCP) and cold hardiness in alfalfa weevil was investigated. Adults were collected monthly from alfalfa fields in Karaj, Iran, during autumn, winter, and spring in 2011-2012...
May 23, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28534737/integration-of-tmc1-2-into-the-mechanotransduction-complex-in-zebrafish-hair-cells-is-regulated-by-transmembrane-o-methyltransferase-tomt
#2
Timothy Erickson, Clive P Morgan, Jennifer Olt, Katherine Hardy, Elisabeth M Busch-Nentwich, Reo Maeda, Rachel Clemens-Grisham, Jocelyn F Krey, Alex V Nechiporuk, Peter G Barr-Gillespie, Walter Marcotti, Teresa Nicolson
Transmembrane O-methyltransferase (TOMT / LRTOMT) is responsible for non-syndromic deafness DFNB63. However, the specific defects that lead to hearing loss have not been described. Using a zebrafish model of DFNB63, we show that the auditory and vestibular phenotypes are due to a lack of mechanotransduction (MET) in Tomt-deficient hair cells. GFP-tagged Tomt is enriched in the Golgi of hair cells, suggesting that Tomt might regulate the trafficking of other MET components to the hair bundle. We found that Tmc1/2 proteins are specifically excluded from the hair bundle in tomt mutants, whereas other MET complex proteins can still localize to the bundle...
May 23, 2017: ELife
https://www.readbyqxmd.com/read/28533695/the-triallelic-serotonin-transporter-gene-polymorphism-is-associated-with-depressive-symptoms-in-adults-with-chronic-pain
#3
W Michael Hooten, Cynthia O Townsend, Christopher D Sletten
BACKGROUND: The serotonin (5-HT) transporter-linked polymorphic region (5-HTTLPR) moderates the relationship between stressful life events and depression. Given the high prevalence of depression in chronic pain, the primary aim of this preliminary study was to investigate the associations between the 5-HTTLPR and the severity of depressive symptoms in a cohort of adults with chronic pain. METHODS: Adults with chronic pain who were consecutively admitted to an outpatient pain rehabilitation program and met inclusion criteria were recruited for study participation (n=277)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28533558/investigating-the-causal-effect-of-smoking-on-hay-fever-and-asthma-a-mendelian-randomization-meta-analysis-in-the-carta-consortium
#4
Tea Skaaby, Amy E Taylor, Rikke K Jacobsen, Lavinia Paternoster, Betina H Thuesen, Tarunveer S Ahluwalia, Sofus C Larsen, Ang Zhou, Andrew Wong, Maiken E Gabrielsen, Johan H Bjørngaard, Claudia Flexeder, Satu Männistö, Rebecca Hardy, Diana Kuh, Sarah J Barry, Line Tang Møllehave, Charlotte Cerqueira, Nele Friedrich, Tobias N Bonten, Raymond Noordam, Dennis O Mook-Kanamori, Christian Taube, Leon E Jessen, Alex McConnachie, Naveed Sattar, Mark N Upton, Charles McSharry, Klaus Bønnelykke, Hans Bisgaard, Holger Schulz, Konstantin Strauch, Thomas Meitinger, Annette Peters, Harald Grallert, Ellen A Nohr, Mika Kivimaki, Meena Kumari, Uwe Völker, Matthias Nauck, Henry Völzke, Chris Power, Elina Hyppönen, Torben Hansen, Torben Jørgensen, Oluf Pedersen, Veikko Salomaa, Niels Grarup, Arnulf Langhammer, Pål R Romundstad, Frank Skorpen, Jaakko Kaprio, Marcus R Munafò, Allan Linneberg
Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic variants as markers of exposures to examine causal effects. We examined the causal effect of smoking on hay fever and asthma by using the smoking-associated single nucleotide polymorphism (SNP) rs16969968/rs1051730. We included 231,020 participants from 22 population-based studies. Observational analyses showed that current vs never smokers had lower risk of hay fever (odds ratio (OR) = 0·68, 95% confidence interval (CI): 0·61, 0·76; P < 0·001) and allergic sensitization (OR = 0·74, 95% CI: 0·64, 0·86; P < 0·001), but similar asthma risk (OR = 1·00, 95% CI: 0·91, 1·09; P = 0·967)...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28532149/proteomic-analysis-of-pigeonpea-cajanus-cajan-seeds-reveals-the-accumulation-of-numerous-stress-related-proteins
#5
Hari B Krishnan, Savithry S Natarajan, Nathan W Oehrle, Wesley M Garrett, Omar Darwish
Pigeonpea is one of the major sources of dietary protein for more than a billion people living in South Asia. This hardy legume is often grown in low-input and risk-prone marginal environments. Considerable research effort has been devoted by a global research consortium to develop genomic resources for the improvement of this legume crop. These efforts have resulted in the elucidation of the complete genome sequence of pigeonpea. Despite these developments, little is known about seed proteome of this important crop...
May 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28530117/combined-impact-of-smoking-and-early-life-exposures-on-adult-lung-function-trajectories
#6
James P Allinson, Rebecca Hardy, Gavin C Donaldson, Seif O Shaheen, Diana Kuh, Jadwiga A Wedzicha
BACKGROUND: Both adverse early life exposures and adult smoking can negatively influence adult lung function trajectory but few studies consider how the impact of early life exposures may be modified by subsequent smoking. METHODS: The Medical Research Council National Survey of Health and Development is a nationally representative cohort, initially of 5362 individuals, followed since enrolment at birth in March 1946. Using data collected prospectively across life and multilevel modelling we investigated how the relationships between early life exposures (infant lower respiratory infection, manual social class, home overcrowding and pollution exposure) and FEV1 and FVC trajectories between ages 43 and 60-64 were influenced by smoking behaviour...
May 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28529593/her2-pro1170ala-polymorphism-is-associated-with-decreased-survival-rate-in-her2-negative-breast-cancer
#7
Pilei Si, Ye Xu, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie
The Pro1170Ala polymorphism is one of the most common polymorphisms of human epidermal growth factor receptor 2 (HER2) and may affect the clinical outcome in breast cancer. Therefore, in the present study, the incidence of the HER2 Pro1170Ala polymorphism was determined in 3,305 female patients with operable primary breast cancer using a DNA-sequencing assay, and the potential association with survival was investigated. Of these 3,305 patients, 29% (955/3,305) were homozygous for the Pro/Pro genotype, 51% (1,679/3,305) were heterozygous for the Pro/Ala genotype and 20% (671/3,305) were homozygous for the Ala/Ala genotype...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28529436/higher-order-riesz-transforms-for-hermite-expansions
#8
Jizheng Huang
In this paper, we consider the Riesz transform of higher order associated with the harmonic oscillator [Formula: see text], where Δ is the Laplacian on [Formula: see text]. Moreover, the boundedness of Riesz transforms of higher order associated with Hermite functions on the Hardy space is proved.
2017: Journal of Inequalities and Applications
https://www.readbyqxmd.com/read/28529230/the-adolescent-condition-in-thomas-hardy-s-i-the-woodlanders-i
#9
Rosanna Nunan
In The Woodlanders, Hardy examines the intersections between adolescence as scientific fact and adolescence as utilitarian economic construction. Hardy posits that the emergence of adolescence as a social category provides an opportunity for further, excessive control of young women in a patriarchal society when science is taken at its word, but, paradoxically, also opens up a space for a new kind of freedom and rebellion when the adolescent condition of nineteenth-century scientific theorists is seized for the very subversive qualities which the Victorians oppose...
2017: Literature and Medicine
https://www.readbyqxmd.com/read/28528697/an-embryonic-stem-cell-specific-nurd-complex-functions-through-interaction-with-wdr5
#10
Ly-Sha Ee, Kurtis N McCannell, Yang Tang, Nancy Fernandes, W Rod Hardy, Michael R Green, Feixia Chu, Thomas G Fazzio
The Nucleosome Remodeling and Deacetylase (NuRD) complex is a chromatin regulatory complex that functions as a transcriptional co-repressor in metazoans. The NuRD subunit MBD3 is essential for targeting and assembly of a functional NuRD complex as well as embryonic stem cell (ESC) pluripotency. Three MBD3 isoforms (MBD3A, MBD3B, and MBD3C) are expressed in mouse. Here, we find that the MBD3C isoform contains a unique 50-amino-acid N-terminal region that is necessary for MBD3C to specifically interact with the histone H3 binding protein WDR5...
May 17, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28528372/associations-between-ptpn22-and-tlr9-polymorphisms-and-systemic-lupus-erythematosus-a-comprehensive-meta-analysis
#11
Li-Ya Hu, Zhi Cheng, Bo Zhang, Qiong Yin, Xiao-Wei Zhu, Pian-Pian Zhao, Ming-Yu Han, Xiao-Bo Wang, Hou-Feng Zheng
Previous studies have explored the relationship of PTPN22 and TLR9 polymorphisms with systemic lupus erythematosus (SLE). In consideration of the population stratification, conflicting results and updating data, we conducted a comprehensive meta-analysis, which consists of a total of 17 research articles (9120 cases and 11,724 controls) for PTPN22 and 20 articles (including up to 2808 cases and 3386 controls) for TLR9. Significant association was verified between PTPN22 rs2476601 and SLE in the overall population (OR = 1...
May 20, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28528221/bronchopulmonary-dysplasia-and-perinatal-characteristics-predict-1-year-respiratory-outcomes-in-newborns-born-at-extremely-low-gestational-age-a-prospective-cohort-study
#12
Roberta L Keller, Rui Feng, Sara B DeMauro, Thomas Ferkol, William Hardie, Elizabeth E Rogers, Timothy P Stevens, Judith A Voynow, Scarlett L Bellamy, Pamela A Shaw, Paul E Moore
OBJECTIVE: To assess the utility of clinical predictors of persistent respiratory morbidity in extremely low gestational age newborns (ELGANs). STUDY DESIGN: We enrolled ELGANs (<29 weeks' gestation) at ≤7 postnatal days and collected antenatal and neonatal clinical data through 36 weeks' postmenstrual age. We surveyed caregivers at 3, 6, 9, and 12 months' corrected age to identify postdischarge respiratory morbidity, defined as hospitalization, home support (oxygen, tracheostomy, ventilation), medications, or symptoms (cough/wheeze)...
May 17, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28527282/-determination-of-hla-a-b-and-drb1-polymorphism-in-brain-dead-organ-donors-representative-of-the-colombian-general-population-2007-2014
#13
Yazmin Rocío Arias, Karime Osorio-Arango, Brayan Bayona, Guadalupe Ercilla, Mauricio Beltrán-Durán
INTRODUCTION: Genes encoding for human leukocyte antigens (HLA) are highly polymorphic and of great importance in organ transplantation procedures, as determining allelic frequencies in defined populations is taken into account among the scientific criteria for organ allocation. OBJECTIVE: The objective of this study was to establish the antigen HLA-A, -B, and -DRB1 haplotype frequencies in organ donors representative of the Colombian population after brain death...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527097/the-flexibility-scale-development-and-preliminary-validation-of-a-cognitive-flexibility-measure-in-children-with-autism-spectrum-disorders
#14
John F Strang, Laura G Anthony, Benjamin E Yerys, Kristina K Hardy, Gregory L Wallace, Anna C Armour, Katerina Dudley, Lauren Kenworthy
Flexibility is a key component of executive function, and is related to everyday functioning and adult outcomes. However, existing informant reports do not densely sample cognitive aspects of flexibility; the Flexibility Scale (FS) was developed to address this gap. This study investigates the validity of the FS in 221 youth with ASD and 57 typically developing children. Exploratory factor analysis indicates a five-factor scale: Routines/rituals, transitions/change, special interests, social flexibility, and generativity...
May 19, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28525620/cold-hardiness-of-the-black-soldier-fly-diptera-stratiomyidae
#15
Thomas Spranghers, Annelies Noyez, Kristof Schildermans, Patrick De Clercq
The black soldier fly, Hermetia illucens (L.), shows potential as a resource for animal feed. However, industrial production in regions where the insect is not native, like northwestern Europe, could lead to permanent establishment, which might entail environmental risks. In temperate climates, establishment depends on the insect's ability to overwinter. This study assessed the insect's cold hardiness by determining the supercooling point (SCP) and lower lethal time at 5 °C (LTime10,50,90) for different life stages...
May 19, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28522540/orthogonal-estimates-of-variances-for-additive-dominance-and-epistatic-effects-in-populations
#16
Z G Vitezica, A Legarra, M A Toro, L Varona
Genomic prediction methods based on multiple markers have potential to include non-additive effects in prediction and analysis of complex traits. However, most developments assume Hardy-Weinberg equilibrium (HWE). Statistical approaches for genomic selection that account for dominance and epistasis in a general context, without assuming HWE (e.g. crosses or homozygous lines), are therefore needed. Our method expands the NOIA orthogonal approach, that builds incidence matrices based on genotypic (not allelic) frequencies, to include genome-wide epistasis for an arbitrary number of interacting loci in a genomic evaluation context...
May 18, 2017: Genetics
https://www.readbyqxmd.com/read/28522227/promoting-motor-skills-in-low-income-ethnic-children-the-physical-activity-in-linguistically-diverse-communities-paldc-nonrandomized-trial
#17
Anthony D Okely, Louise L Hardy, Marijka Batterham, Phillip Pearson, Kim McKeen, Lauren Puglisi
OBJECTIVES: This study reports the long-term effects of a professional learning program for classroom teachers on fundamental motor skill (FMS) proficiency of primary school students from ethnically diverse backgrounds. DESIGN: A cluster non-randomized trial using a nested cross-sectional design. METHODS: The study was conducted in 8 primary schools located in disadvantaged and culturally diverse areas in Sydney, Australia. The intervention used an action learning framework, with each school developing and implementing an action plan for enhancing the teaching of FMS in their school...
May 8, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28521645/exploring-protective-strategies-among-rural-women-in-an-abusive-relationship
#18
Kim M Anderson, Lynette M Renner, Tina L Bloom
The purpose of this study was to explore rural women's accounts of intimate partner violence and the strategies they used to protect themselves from such adversity. Convenience sampling included women currently in an abusive relationship (N = 22), who were receiving mental health services at a rural victim-service provider. Standardized measures indicated, on average, that study participants were symptomatic for depression, anxiety and posttraumatic stress disorder (PTSD), yet exhibited higher resilience than other PTSD populations...
May 19, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28521197/association-of-%C3%AE-3-adrenergic-receptor-rs4994-polymorphisms-with-the-risk-of-type-2-diabetes-a-systematic-review-and-meta-analysis
#19
Jin Ah Ryuk, Xin Zhang, Byoung-Seob Ko, James W Daily, Sunmin Park
AIM: The association of ADRB3 polymorphism with the risk of T2DM remains unclear perhaps due to different ethnicities and small study sizes. We systemically evaluated the association of β3-adrenergic receptor(ADRB3)rs4994 and type 2 diabetes(T2DM) by pooling all of the case-control studies reported, and also elucidated the association according to the ethnicity and obesity of the subjects. METHODS: A literature search was conducted using PubMed, EMBASE, Cochrane Library, Korean scientific database, Chinese medical databases, and the Indian medical database to identify eligible studies for determining the association of ADRB3 rs4994 and T2DM risk...
May 5, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28520958/the-development-use-and-impact-of-a-global-laboratory-database-during-the-2014-ebola-outbreak-in-west-africa
#20
Kara N Durski, Shalini Singaravelu, Junxiong Teo, Dhamari Naidoo, Luke Bawo, Amara Jambai, Sakoba Keita, Ali Ahmed Yahaya, Beatrice Muraguri, Brice Ahounou, Victoria Katawera, Fredson Kuti-George, Yacouba Nebie, T Henry Kohar, Patrick Jowlehpah Hardy, Mamoudou Harouna Djingarey, David Kargbo, Nuha Mahmoud, Yewondwossen Assefa, Orla Condell, Magassouba N'Faly, Leon Van Gurp, Margaret Lamanu, Julia Ryan, Boubacar Diallo, Foday Daffae, Dikena Jackson, Fayyaz Ahmed Malik, Philomena Raftery, Pierre Formenty
Background: The international impact, rapid widespread transmission, and reporting delays during the 2014 Ebola virus disease (EVD) outbreak in West Africa highlighted the need for a global, centralized database to inform outbreak response. The World Health Organization and Emerging and Dangerous Pathogens Laboratory Network addressed this need by supporting the development of a global laboratory database. Methods: Specimens were collected in the affected countries from patients and dead bodies meeting the case definitions for EVD...
May 18, 2017: Journal of Infectious Diseases
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