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G Bi, C Zhang, Y Dong, H T Jiao, L Dong, H G Zhou
OBJECTIVES: To analyse the efficiency of EX16+10Y kit on the forensic detection of the Uygur in Xinjiang province. METHODS: The blood samples were extracted from 4 620 male individuals of Uygur in Xinjiang province, and amplified by EX16+10Y kit. The typing of amplification products was performed by 3130 xl genetic analyzer. RESULTS: The genotyping graphs of 15 autosomal STR loci and 10 Y-chromosomal STR loci from 4 620 male individuals of Uygur in Xinjiang province were acquired completely...
April 2018: Fa Yi Xue za Zhi
Y N Li, M Li, L Jiang, X H Luan, N Liang, Q N Xu, J S Zhang, M C Tang, Y N Bian, L Q Chen
OBJECTIVES: To evaluate the application of 43-plex SNP typing system in forensic science. METHODS: The typing of 43 SNP loci in 123 unrelated Han individuals from East China was detected by MALDI-TOF-MS. The application value of 43-plex SNP typing system was assessed according to the forensic parameters of population genetics. RESULTS: All the 43 SNP loci of 123 individuals showed no significant departure from Hardy-Weinberg equilibrium ( P >0...
April 2018: Fa Yi Xue za Zhi
Y Bao, X Sheng, J S Zhang, M Li, Y N Li, Q N Xu, C T Li, L Q Chen
OBJECTIVES: To investigate the genetic polymorphism of 21 autosomal STR loci and DYS391 locus of SiFaSTR™ 23plex DNA ID system in Han population of eastern China and to evaluate its application value in forensic science. METHODS: Typing test of 2 000 unrelated individuals was performed using SiFaSTR™ 23plex DNA ID system. The population genetic parameters of STR loci were statistically analysed. A total of 3 198 parentage confirmed cases were detected with that system and the mutation conditions were observed in 21 autosomal STR loci...
April 2018: Fa Yi Xue za Zhi
Aleena Ahmad Khan, Rukhsana Perveen, Nadeem Sheikh, Babar Hilal Ahmad Abbasi, Zunaira Batool, Muhammad Shahzad, Sana Kaleem
Allele frequencies and forensic statistical parameters of 15 autosomal short tandem repeats (STRs) were evaluated in 200 genetically unrelated individuals of the Baloch population of Pakistan. Total 155 alleles were observed with allele frequencies ranged from 0.003 to 0.425. Among the 15 STRs, D2S1338 was found to be the most polymorphic and discriminating locus while TPOX was the least polymorphic and discriminating locus. The combined power of discrimination (CPD), combined power of exclusion (CPE), and combined matching probability (CMP) were found to be 0...
June 20, 2018: International Journal of Legal Medicine
Fatemeh Mashhadiabbas, Hossein Neamatzadeh, Rezvan Nasiri, Elnaz Foroughi, Soudabeh Farahnak, Parisa Piroozmand, Mahta Mazaheri, Masoud Zare-Shehneh
Background: There has been increasing interest in the study of the association between Vitamin D receptor (VDR) gene polymorphisms and risk of chronic periodontitis. However, the results remain inconclusive. To better understand the roles of VDR polymorphisms (BsmI, TaqI, FokI, and ApaI) in chronic periodontitis susceptibility, we conducted this systematic review and meta-analysis. Materials and Methods: The PubMed, Google Scholar, and Web of Science database were systemically searched to determine all the eligible studies about VDR polymorphisms and risk of chronic periodontitis up to April 2017...
May 2018: Dental Research Journal
Chenchen Zhao, Fangzhou Ma, Hongsong Chen, Fanghao Wan, Jianying Guo, Zhongshi Zhou
Chill tolerance plays a crucial role that allows insect species to adapt to cold environments. Two Chinese geographical populations (Laibin and Yangzhou populations) were selected to understand the chill resistance and evolutionary potential in the Ophraella communa , a biological control agent of the invasive common ragweed, Ambrosia artemisiifolia . Super-cooling point assays, knockdown tests under static low-temperature conditions and determination of glycerol content were studied. ANOVAs indicated significant differences regarding chill coma recovery time, super-cooling point, and glycerol content across populations and sexes...
2018: Frontiers in Physiology
Ebru Dundar Yenilmez, Lut Tamam, Onur Karaytug, Abdullah Tuli
BACKGROUND: The interindividual genetic variations in drug metabolizing enzymes effects the impact and toxicity in plenty of drugs. OBJECTIVE: The CYP1A2, CYP2C9, CYP2C19 and CYP2D6 gene polymorphisms characterized using high resolution melting analysis (HRMA) in follow-up patients in psychiatry clinic as a preliminary preparation for personalized medicine. METHOD: Genotyping of CYP1A2*1F, CYP2C9 *2, *3, CYP2C19 *2, *3 and *17 and CYP2D6 *3, *4 was conducted in 101 patients using HRMA...
June 19, 2018: Combinatorial Chemistry & High Throughput Screening
Brett R Aiello, Adam R Hardy, Mark W Westneat, Melina E Hale
Mechanosensation is a universal feature of animals that is essential for behavior, allowing detection of animals' own body movement and position as well as physical features of the environment. Fish fins provide a key vertebrate system for studying mechanosensation. The extraordinary morphological and behavioral diversity that exists across fish species provide rich opportunities for comparative mechanosensory studies in fins. The fins of fishes have been found to function as proprioceptors, by providing feedback on fin ray position and movement, and as tactile sensors, by encoding pressures applied to the fin surface...
June 18, 2018: Integrative and Comparative Biology
Keeley J Brookes, George McConnell, Kirsty Williams, Sultan Chaudhury, Gaganjit Madhan, Tulsi Patel, Christopher Turley, Tamar Guetta-Baranes, Jose Bras, Rita Guerreiro, John Hardy, Paul T Francis, Kevin Morgan
The Brains for Dementia Research project is a recently established longitudinal cohort which aims to provide brain tissue for research purposes from neuropathologically defined samples. Here we present the findings from our analysis on the 19 established GWAS index SNPs for Alzheimer's disease, in order to demonstrate if the BDR sample also displays association to these variants. A highly significant association of the APOEɛ4 allele was identified (p = 3.99×10-12). Association tests for the 19 GWAS SNPs found that although no SNPs survive multiple testing, nominal significant findings were detected and concordance with the Lambert et al...
June 8, 2018: Journal of Alzheimer's Disease: JAD
Parth Nalin Vakil, David A Hardy, Geoffrey F Strouse
As the importance of anisotropic nanostructures and their unique surfaces continues to rise in applications including catalysis, magneto-optics and electromagnetic interference shielding, there is a need for efficient and economical synthesis routes for such nanostructures. The manuscript describes the application of cycled microwave-based heating for the rapid synthesis of highly branched pure phase fcc crystalline nickel mulitpods nanostructures with >99% multipod population. By controlling the power delivery to the reaction mixture through cycling, superior control is achieved over the growth kinetics of the metallic nanostructures allowing formation of multipods consisting of arms with different aspect ratios...
June 18, 2018: ACS Nano
Sreenath Madathil, Lawrence Joseph, Rebecca Hardy, Marie-Claude Rousseau, Belinda Nicolau
Background: Different hypotheses have been proposed in life course epidemiology on how a time-varying exposure can affect health or disease later in life. Researchers are often interested in investigating the probability of these hypotheses based on observed life course data. However, current techniques based on model/variable selection do not provide a direct estimate of this probability. We propose an alternative technique for a continuous exposure, using a Bayesian approach that has specific advantages, to investigate which life course hypotheses are supported by the observed data...
June 14, 2018: International Journal of Epidemiology
Annette Humm, Debra Kaminer, Anneli Hardy
OBJECTIVE: Cumulative violence exposure has been associated with both internalising and externalising difficulties in youth. Therefore, it is important to identify protective factors that may ameliorate both exposure to and the impact of cumulative violence. This study aimed to identify sources of perceived social support amongst early adolescents in a low-income, high-violence community in South Africa, and to examine the association of perceived support with exposure to violence and with the severity of depression, aggression and conduct disorder symptoms...
May 2018: Journal of Child and Adolescent Mental Health
C Sartori, V Perreten, I Ivanovic, M C Härdi-Landerer, H U Graber
In Switzerland, sanitation programs of dairy herds infected with the contagious mastitis pathogen Staphylococcus aureus genotype B (GTB) have been established for several years. In recent years, Streptococcus uberis and non-aureus staphylococci have emerged as the bacteria most frequently isolated from bovine milk samples. The latter cause subclinical mastitis, and some species are more persistent or pathogenic than others. The present study aimed to investigate the developments in the intramammary colonization spectrum of 5 dairy herds undergoing a sanitation program for Staph...
June 13, 2018: Journal of Dairy Science
Martin P McHugh, Daniel Guerendiain, Alison Hardie, Juliet Kenicer, Laura MacKenzie, Kate E Templeton
BACKGROUND: Norovirus is a leading cause of infectious gastroenteritis, characterized by outbreaks of diarrhoea and vomiting in closed settings. Nucleic acid amplification tests allow rapid and sensitive laboratory diagnosis of norovirus, with a number of commercial platforms now available. OBJECTIVES: Evaluate the performance of the Becton Dickinson BD-MAX™System, Cepheid Xpert® Norovirus Assay, and Luminex xTAG® Gastrointestinal Pathogen Panel (GPP) for norovirus detection in stool...
June 8, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
YongFeng Pei, HuiNi Huang, HengCong Li, JieRun Chen, GuoGuang Wu
The distribution of human leucocyte antigen (HLA) allele and haplotype varied among different ethnic populations. In this study, we investigated the allele and haplotype frequencies of HLA-A, HLA-B and HLA-DRB1 loci in the Nanning Han population who live in Guangxi province of China. We identified 26 HLA-A, 56 HLA-B and 31 HLA-DRB1 alleles in 562 Nanning individuals of Han ethnic group by sequence-based typing method. Of these, the three most common alleles in HLA-A, HLA-B and HLA-DRB1 loci, respectively, were A*11:01 (32...
June 15, 2018: International Journal of Immunogenetics
Muqing Gu, Lijuan Wang, Chun Yang, Xue Li, Chanwei Jia, Stephane Croteau, Xiangyan Ruan, Pierre Hardy
BACKGROUND: Recent investigations have indicated that hormone therapy may increase the risk of breast cancer (BC), and the addition of synthetic progestins may play a critical role in this. Several studies have pointed out the important role of progesterone receptor membrane component 1 (PGRMC1) in the development of BC, especially with hormone therapy using progestins. Although the deregulation of microRNA-181a (miR-181a) is often associated with human BC, the effect of miR-181a on PGRMC1 expression during hormone therapy has not been investigated...
August 2018: Maturitas
Rowan S Hardy, Hong Zhou, Markus J Seibel, Mark S Cooper
Osteoporosis associated with long-term glucocorticoid therapy remains a common and serious bone disease. In addition, in recent years it has become clear that more subtle states of endogenous glucocorticoid excess may have a major impact on bone health. Adverse effects can be seen with mild systemic glucocorticoid excess but there is also evidence of tissue-specific regulation of glucocorticoid action within bone as a mechanism of disease. This review article will examine a) the role of endogenous glucocorticoids in normal bone physiology, b) the skeletal effects of endogenous glucocorticoid excess in the context of endocrine conditions such as Cushing's disease/syndrome and autonomous cortisol secretion (subclinical Cushing's syndrome), and c) the actions of therapeutic (exogenous) glucocorticoids on bone...
June 13, 2018: Endocrine Reviews
Jennifer L Saylor, Christina J Calamaro, Thomas Hardie, Michelle Ness, Janice Selekman
BACKGROUND AND PURPOSE: Communication about risk factors for diabetes between nurse practitioners and college students may not be occurring as the prevalence of Type 2 diabetes increases. The purpose of this secondary analysis was to evaluate if college students are being told of their risk for diabetes based on known risk factors of weight, sleep, and depressive symptoms. METHODS: Descriptive, cross-sectional study was completed using National Health and Nutrition Examination Survey 2011-2012...
June 4, 2018: Journal of the American Association of Nurse Practitioners
Hardi Jogi, Rahul Maheshwari, Nidhi Raval, Kaushik Kuche, Vishakha Tambe, Kit-Kay Mak, Mallikarjuna Rao Pichika, Rakesh Kumar Tekade
Cancer is estimated to be a significant health problem of the 21st century. The situation gets even tougher when it comes to its treatment using chemotherapy employing synthetic anticancer molecules with numerous side effects. Recently, there has been a paradigm shift toward the adoption of herbal drugs for the treatment of cancer. In this context, a suitable delivery system is principally warranted to deliver these herbal biomolecules specifically at the tumorous site. To achieve this goal, carbon nanotubes (CNTs) have been widely explored to deliver anticancer herbal molecules with improved therapeutic efficacy and safety...
June 15, 2018: Nanomedicine
Susan Rowland, James Hardy, Kay Colthorpe, Rhianna Pedwell, Louise Kuchel
The ability to communicate is a crucial graduate outcome for science students; however, crowded curricula and large class sizes make it difficult to find time to explicitly teach foundational communication skills. In response to these challenges, we developed an online resource called Communication Learning in Practice for Scientists, or CLIPS. CLIPS provides a multi-point mentoring model that has allowed us to successfully integrate the teaching and learning of a complex set of tacitly-understood skills across multiple scientific disciplines...
2018: Journal of Microbiology & Biology Education: JMBE
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