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https://www.readbyqxmd.com/read/29471369/genome-wide-association-study-of-stayability-and-heifer-pregnancy-in-red-angus-cattle
#1
S E Speidel, B A Buckley, R J Boldt, R M Enns, J Lee, M L Spangler, M G Thomas
Reproductive performance is the most important component of cattle production from the standpoint of economic sustainability of commercial beef enterprises. Heifer Pregnancy (HPG) and Stayability (STAY) genetic predictions are two selection tools published by the Red Angus Association of America (RAAA) to assist with improvements in reproductive performance. Given the importance of HPG and STAY to the profitability of commercial beef enterprises, the objective of this study was to identify QTL associated with both HPG and STAY in Red Angus cattle...
February 19, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29469641/castrate-resistant-prostate-cancer-lessons-learnt-from-a-pilot-study-in-the-palliative-care-research-population
#2
Karyn A Sullivan, Ngaire Kingi, Phillip Good, Petra Vayne-Bossert, Janet R Hardy
BACKGROUND: Palliative care patients are inherently difficult to recruit to and retain on studies. Even when patients are recruited, it is hard to complete studies with sufficient data. There is a dearth of literature specific to men with castrate resistant prostate cancer (CRPC) and the clinical trials coordinator/research nurse's perspective in improving trial outcomes in palliative care. Objectives To describe the lessons learnt (by the nursing research team) from a prospective cohort study of men with CRPC and the practical implications for future research in this area...
February 2, 2018: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/29467369/transcriptomic-signature-of-drought-response-in-pearl-millet-pennisetum-glaucum-l-and-development-of-web-genomic-resources
#3
Sarika Jaiswal, Tushar J Antala, M K Mandavia, Meenu Chopra, Rahul Singh Jasrotia, Rukam S Tomar, Jashminkumar Kheni, U B Angadi, M A Iquebal, B A Golakia, Anil Rai, Dinesh Kumar
Pearl millet, (Pennisetum glaucum L.), an efficient (C4) crop of arid/semi-arid regions is known for hardiness. Crop is valuable for bio-fortification combating malnutrition and diabetes, higher caloric value and wider climatic resilience. Limited studies are done in pot-based experiments for drought response at gene-expression level, but field-based experiment mimicking drought by withdrawal of irrigation is still warranted. We report de novo assembly-based transcriptomic signature of drought response induced by irrigation withdrawal in pearl millet...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29467319/escape-of-hepatitis-c-virus-from-epitope-i-neutralization-increases-sensitivity-of-other-neutralization-epitopes
#4
Jun Gu, Joshua Hardy, Irene Boo, Patricia Vietheer, Kathleen McCaffrey, Yousef Alhammad, Abha Chopra, Silvana Gaudieri, Pantelis Poumbourios, Fasséli Coulibaly, Heidi E Drummer
The Hepatitis C Virus (HCV) E2 glycoprotein is a major target of the neutralizing antibody response with multiple type-specific and broadly neutralizing antibody epitopes identified. The 412-423 region can generate broadly neutralizing antibodies (bnNAbs) that block interaction with the cell surface receptor CD81, with activity towards multiple HCV genotypes. In this study we reveal the structure of the rodent MAb24 with an extensive contact area towards a peptide spanning the 412-423 region. The crystal structure of the MAb24-peptide 412-423 complex reveals the paratope bound to a peptide hairpin, highly similar to that observed with human MAb HCV1, but with a different angle of approach...
February 21, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29462797/functional-snp-in-the-3-utr-of-pon1-is-associated-with-the-risk-of-calcific-aortic-valve-stenosis-via-mir-616
#5
Zhengjun Wang, Shiqiao Chen, Mei Zhu, Wenlong Zhang, Haizhou Zhang, Hongxin Li, Chengwei Zou
BACKGROUND/AIMS: Previous studies have examined the associations between the single nucleotide polymorphism in the Paraoxonase 1 (PON1) gene and development of calcific aortic valve stenosis (CAVS). The association between functional SNP in 3'UTR of PON1 and the risk of CAVS, however, is unclear. In this study, we investigated the role of SNP in the regulation of PON1 expression via miR-616, as well as the association of SNP with the risk of CAVS. METHODS: Two hundred and sixteen patients with CAVS and 243 CAVS-free participants were recruited in this study...
February 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29462778/coagulation-behavior-of-humic-acid-in-aqueous-solutions-containing-cs-sr-2-and-eu-3-dls-eem-and-md-simulations
#6
Liqiang Tan, Xiaoli Tan, Huiyang Mei, Yuejie Ai, Lu Sun, Guixia Zhao, Tasawar Hayat, Ahmed Alsaedi, Changlun Chen, Xiangke Wang
The coagulation behaviors of humic acid (HA) with Cs+ (10-500 mM), Sr2+ (0.8-10.0 mM) and Eu3+ (0.01-1.0 mM) at different pH values (2.8, 7.1 and 10.0) were acquired through a dynamic light scattering (DLS) technique combined with spectroscopic analysis and molecular dynamic (MD) simulations. The coagulation rate and the average hydrodynamic diameter (<Dh >) increased significantly as the concentration of nuclides increased. <Dh > could be scaled to time t as <Dh >∝ ta at higher Sr2+ concentrations, which shows that HA coagulation is consistent with the diffusion-limited colloid aggregation (DLCA) model...
February 17, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29460075/a-noise-optimized-virtual-monoenergetic-reconstruction-algorithm-improves-the-diagnostic-accuracy-of-late-hepatic-arterial-phase-dual-energy-ct-for-the-detection-of-hypervascular-liver-lesions
#7
Carlo N De Cecco, Damiano Caruso, U Joseph Schoepf, Domenico De Santis, Giuseppe Muscogiuri, Moritz H Albrecht, Felix G Meinel, Julian L Wichmann, Philip F Burchett, Akos Varga-Szemes, Douglas H Sheafor, Andrew D Hardie
OBJECTIVES: To assess the image quality and diagnostic accuracy of a noise-optimized virtual monoenergetic imaging (VMI+) algorithm compared with standard virtual monoenergetic imaging (VMI) and linearly-blended (M_0.6) reconstructions for the detection of hypervascular liver lesions in dual-energy CT (DECT). METHODS: Thirty patients who underwent clinical liver MRI were prospectively enrolled. Within 60 days of MRI, arterial phase DECT images were acquired on a third-generation dual-source CT and reconstructed with M_0...
February 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29459401/low-dose-gonadotropin-induction-of-ovulation-in-anovulatory-women-still-needed-in-the-age-of-ivf
#8
Davinia White, Kate Hardy, Suzannah Lovelock, Stephen Franks
Low-dose, step-up gonadotropin is the treatment of choice for women with PCOS who have not conceived after anti-estrogen treatment, and as an effective alternative to pulsatile GnRH in women with hypogonadotropic hypogonadism (HH). There has been, however, no large-scale, comparative study between the two groups using low-dose gonadotropins. Here we performed a retrospective, comparative analysis, in a single clinic database, of efficacy and safety of induction of ovulation using low-dose gonadotropins in 364 Women with PCOS and 80 women with HH...
February 19, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29457981/reversible-surface-engineering-via-nitrone-mediated-radical-coupling
#9
Joachim Laun, Wouter Marchal, Vanessa Trouillet, Alexander Welle, An T Hardy, Marlies K Van Bael, Christopher Barner-Kowollik, Tanja Junkers
Efficient and simple polymer conjugation reactions are critical for introducing functionalities on surfaces. For polymer surface grafting, post polymerization modifications are often required, which can impose a significant synthetic hurdle. Here, we report two strategies that allow for reversible surface engineering via nitrone-mediated radical coupling (NMRC). Macroradicals stemming from activation of polymers generated by copper-mediated radical polymerization are grafted via radical trapping with a surface-immobilized nitrone or a solution-borne nitrone...
February 19, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29455458/diagnosis-presentation-and-initial-severity-of-autoimmune-hepatitis-aih-in-patients-attending-28-hospitals-in-the-uk
#10
Victoria Gordon, Ratul Adhikary, Victoria Appleby, Debasis Das, James Day, Toby Delahooke, Selena Dixon, David Elphick, Claire Hardie, Barbara Hoeroldt, Patricia Hooper, John Hutchinson, Rebecca Jones, Faisal Khan, Guruprasad P Aithal, John McGonigle, Andrew Nelson, Alick Nkhoma, Stavroula Pelitari, Martin Prince, Annell Prosser, Vinay Sathanarayana, Sophia Savva, Naina Shah, Sushma Saksena, Sreedhari Thayalasekaran, Deven Vani, Andrew Yeoman, Dermot Gleeson
BACKGROUND AND AIMS: There is limited information regarding patients with AIH outside relatively few large centres. We describe here the presenting features of patients with AIH, collected as part of an audit involving 28 UK hospitals. METHODS: Patients (incident since 1/1/2007 or prevalent since 1/1/2000) were >18 years and either met 1999 International AIH Group (IAIHG) diagnostic criteria (n=1164), or received immunosuppressive therapy for clinically diagnosed AIH (n=103)...
February 17, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29453494/population-genetic-data-of-investigator-hdplex-markers-in-han-population-from-southern-china
#11
Qiuling Liu, Hailun Nan, Xin He, Weiwei Wu, Dejian Lu
Allele frequencies and forensic statistical parameters for 12 STRs contained in the Investigator HDplex Kit (D2S1360, D3S1744, D4S2366, D5S2500, SE33, D6S474, D7S1517, D8S1132, D10S2325, D12S391, D18S51, and D21S2055) were estimated from a sample of 503 unrelated individuals from the Guangdong Han population of South China. No significant departure from the Hardy-Weinberg equilibrium or genetic linkage disequilibrium was observed (after Bonferroni correction). The expected heterozygosity ranged from 0.6411 to 0...
February 17, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29452770/single-arm-phase-2-trial-of-elective-nodal-dose-reduction-for-patients-with-locoregionally-advanced-squamous-cell-carcinoma-of-the-head-and-neck
#12
Patrick D Maguire, Charles R Neal, Stuart M Hardy, Andrew M Schreiber
PURPOSE: To evaluate a novel chemoradiation therapy (CRT) regimen for patients with squamous cell carcinoma of the head and neck (SCCHN) incorporating a lower intensity modulated radiation therapy dose to electively treated neck lymph nodes than is currently standard. METHODS AND MATERIALS: Eligible patients had locally advanced SCCHN of the oral cavity, oropharynx, larynx, or hypopharynx. The 7-week CRT course consisted of weekly cisplatin at 35 mg/m 2 concurrently with sequential-boost intensity modulated radiation therapy: 36 Gy to high- and low-risk planning target volumes followed by a sequential boost to the high-risk planning target volume to 70 Gy...
December 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29452064/college-students-with-congenital-heart-disease-a-critical-time-for-transition
#13
Rose Y Hardy, Michelle Gurvitz, Jamie L Jackson, Susan May, Paula Miller, Rachel Daskalov, Elyse Foster
No abstract text is available yet for this article.
February 16, 2018: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/29449297/delivering-safe-and-effective-test-result-communication-management-and-follow-up-a-mixed-methods-study-protocol
#14
Maria R Dahm, Andrew Georgiou, Johanna I Westbrook, David Greenfield, Andrea R Horvath, Denis Wakefield, Ling Li, Ken Hillman, Patrick Bolton, Anthony Brown, Graham Jones, Robert Herkes, Robert Lindeman, Michael Legg, Meredith Makeham, Daniel Moses, Dauda Badmus, Craig Campbell, Rae-Anne Hardie, Julie Li, Euan McCaughey, Gorkem Sezgin, Judith Thomas, Nasir Wabe
INTRODUCTION: The failure to follow-up pathology and medical imaging test results poses patient-safety risks which threaten the effectiveness, quality and safety of patient care. The objective of this project is to: (1) improve the effectiveness and safety of test-result management through the establishment of clear governance processes of communication, responsibility and accountability; (2) harness health information technology (IT) to inform and monitor test-result management; (3) enhance the contribution of consumers to the establishment of safe and effective test-result management systems...
February 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29446527/nonbinary-quantification-technique-accounting-for-myocardial-infarct-heterogeneity-feasibility-of-applying-percent-infarct-mapping-in-patients
#15
Domenico Mastrodicasa, Gabriel A Elgavish, U Joseph Schoepf, Pal Suranyi, Marly van Assen, Moritz H Albrecht, Carlo N De Cecco, Rob J van der Geest, Rayphael Hardy, Cesare Mantini, L Parkwood Griffith, Balazs Ruzsics, Akos Varga-Szemes
BACKGROUND: Binary threshold-based quantification techniques ignore myocardial infarct (MI) heterogeneity, yielding substantial misquantification of MI. PURPOSE: To assess the technical feasibility of MI quantification using percent infarct mapping (PIM), a prototype nonbinary algorithm, in patients with suspected MI. STUDY TYPE: Prospective cohort POPULATION: Patients (n = 171) with suspected MI referred for cardiac MRI. FIELD STRENGTH/SEQUENCE: Inversion recovery balanced steady-state free-precession for late gadolinium enhancement (LGE) and modified Look-Locker inversion recovery (MOLLI) T1 -mapping on a 1...
February 15, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29444992/microbiological-control-for-affinity-capture-chromatography-processing-an-industry-perspective
#16
Marie Murphy, Brian Bell, James Moshi, Robert Grassi, Ren-Yo Forng, Angel Salaman, Petra Wawra Jordi, Simin Zaidi, Marcella Goodnight, Kim McFarland, Diane Hardy, Michael Knight, Mousumi Paul, Andreas Keller, Bill Carpenter, Donal McLaughlin, Una Hearty, Jose Marrero, David Bain, Derek Willison-Parry
The purpose of this paper is to provide a summary of a BPOG-led industry survey of the microbiological control aspects of affinity chromatography processing in the biopharmaceutical industry. The document provides a summary of historical microbiological control concerns, coupled with industry-derived best practices for material, equipment, and storage controls required to mitigate the potential for microbial ingress and contamination of chromatography resin and equipment. These best practice guidelines, which are derived from the members of the BPOG Bioburden Working Group, are intended to assist biopharmaceutical manufacturers enhance microbial control and monitoring strategies for chromatography systems...
February 14, 2018: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/29444373/changes-in-apoplastic-peroxidase-activity-and-cell-wall-composition-are-associated-to-cold-induced-morpho-anatomical-plasticity-of-wheat-leaves
#17
Máximo Lorenzo, Marcela L Pinedo, María A Equiza, Paula V Fernández, Marina Ciancia, Darío G Ganem, Jorge A Tognetti
Temperate grasses, such as wheat, become compact plants with small, thick leaves after exposure to low temperature. These responses are associated with cold hardiness, but their underlying mechanisms remain largely unknown. Here we analyze the effects of low temperature on leaf morpho-anatomical structure, cell wall composition and the activity of extracellular peroxidases, which play key roles on cell elongation and cell wall thickening, in two wheat cultivars with contrasting cold-hardening abilities. A combined microscopic and biochemical approach was applied to study actively growing leaves of winter (ProINTA-Pincén) and spring (Buck-Patacón) wheat developed under constant warm (25 °C) or low (5 °C) temperature...
February 14, 2018: Plant Biology
https://www.readbyqxmd.com/read/29444240/isolation-and-characterization-of-novel-polymorphic-microsatellite-markers-for-cimex-hemipterus-f-hemiptera-cimicidae
#18
Siti Nor Ain Seri Masran, Abdul Hafiz Ab Majid
Due to the growing public health and tourism awareness, Cimex hemipterus Fabricius (Hemiptera: Cimicidae) has gained a great interest in increasing reported infestation cases in tropical regions of the world, including Malaysia. Since the information on the molecular ecology and population biology of this species are tremendously lacking, the isolation and development of molecular markers can be used to determine its genetic structure. In this study, novel microsatellite primers isolated from enriched genomic libraries of C...
February 10, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29443635/race-differences-in-linking-family-formation-transitions-to-women-s-mortality
#19
Adriana M Reyes, Melissa Hardy, Eliza Pavalko
We examine how the timing and sequencing of first marriage and childbirth are related to mortality for a cohort of 4,988 white and black women born between 1922 and 1937 from the National Longitudinal Survey of Mature Women. We use Cox proportional hazard models to estimate race differences in the association between family formation transitions and mortality. Although we find no relationships between marital histories and longevity, we do find that having children, the timing of first birth, and the sequencing of childbirth and marriage are associated with mortality...
February 1, 2018: Journal of Health and Social Behavior
https://www.readbyqxmd.com/read/29442414/frequent-lunch-purchases-from-nsw-school-canteens-a-potential-marker-for-children-s-eating-habits
#20
Louise L Hardy, Bridget Foley, Stephanie R Partridge, James Kite, Adrian Bauman, Josephine Chau, Seema Mihrshahi
No abstract text is available yet for this article.
February 14, 2018: Australian and New Zealand Journal of Public Health
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