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Neonatal infection

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https://www.readbyqxmd.com/read/29475199/the-role-of-a-single-dose-of-vancomycin-in-reducing-clinical-sepsis-in-premature-infants-prior-to-removal-of-peripherally-inserted-central-catheter-a-retrospective-study
#1
Vidit Bhargava, Lovya George, Michael Malloy, Rafael Fonseca
OBJECTIVE:  Peripherally inserted central catheter (PICC) line removal is associated with bloodstream infections and clinical sepsis. We aim to investigate the role of a single prophylactic dose of vancomycin in decreasing the incidence of central line associated bloodstream infection associated with PICC removal. METHODS:  A retrospective chart review of patients in the neonatal intensive care unit was conducted. Patients were divided into two study groups based on whether a single dose of vancomycin was administered (exposed) or not (nonexposed)...
February 23, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29472994/seroprevalence-of-hepatitis-b-virus-in-taiwan-30-years-after-the-commencement-of-the-national-vaccination-program
#2
Yang-Cheng Hu, Chih-Ching Yeh, Ruey-Yu Chen, Chien-Tien Su, Wen-Chang Wang, Chyi-Huey Bai, Chi-Fei Chan, Fu Hsiung Su
Background: In this study, the long-term efficacy of hepatitis B virus (HBV) vaccination was assessed using seroprevalence and an age-period-cohort (APC) model of HBV seromarkers among university entrants 30 years after the introduction of the national neonatal HBV vaccination program in Taiwan. Methods: In total, data of 17,611 university entrants who underwent university entrance health examinations between 2005 and 2016 were included. The seroprevalence of the HBV surface antigen (HBsAg) and the levels of the antibody against the HBV surface antigen (anti-HBs) in each year group and sex were calculated...
2018: PeerJ
https://www.readbyqxmd.com/read/29472491/child-health-outcomes-after-presumptive-infection-treatment-in-pregnant-women-a-randomized-trial
#3
Lotta Hallamaa, Yin Bun Cheung, Kenneth Maleta, Mari Luntamo, Ulla Ashorn, Melissa Gladstone, Teija Kulmala, Charles Mangani, Per Ashorn
BACKGROUND AND OBJECTIVES: We showed earlier that presumptive infection treatment in pregnancy reduced the prevalence of neonatal stunting in a rural low-income setting. In this article, we assess how these gains were sustained and reflected in childhood growth, development, and mortality. METHODS: We enrolled 1320 pregnant Malawian women in a randomized trial and treated them for malaria and other infections with either 2 doses of sulfadoxine-pyrimethamine (SP) (control), monthly SP, or monthly sulfadoxine-pyrimethamine and 2 doses of azithromycin (AZI-SP)...
February 22, 2018: Pediatrics
https://www.readbyqxmd.com/read/29471383/genetic-analysis-of-calf-health-in-charolais-beef-cattle
#4
A Vinet, H Leclerc, F Marquis, F Phocas
The objective of this study was to investigate the factors that influence calf health and survival in Charolais cattle. Data from 2,740 calves, originating from 16 French farms and observed from birth until 30 d of age, were analyzed using models that took account of direct genetic, maternal genetic and common environmental effects. Both direct and maternal genetic parameters were estimated for birth weight (BW), calving ease (CE), neonatal vitality (NV), survival at 30 d (Surv), and umbilical infection and diarrhea at different ages (0-5 d: Umb1 and Diar1; 6-20 d: Umb2 and Diar2; and 21-30 d: Umb3 and Diar3)...
February 19, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29470994/a-virus-like-particle-vaccine-protects-mice-against-coxsackievirus-a10-lethal-infection
#5
Yu Zhou, Chao Zhang, Qingwei Liu, Sitang Gong, Lanlan Geng, Zhong Huang
Coxsackievirus A10 (CVA10) has emerged worldwide as one of the main pathogens of hand, foot, and mouth disease (HFMD) in recent years. However, there is currently no commercial vaccine available to prevent CVA10 infection. Here we report the development of a recombinant virus-like particle (VLP) based candidate vaccine for CVA10. Co-expression of the capsid protein precursor P1 and the protease 3CD of CVA10 in Pichia pastoris resulted in cleavage of P1 into three capsid subunit proteins VP0, VP1, and VP3. These three subunit proteins co-assembled into CVA10 VLPs, which were visualized as spherical particles with a diameter of ∼30 nm under electron microscope...
February 19, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29470360/oral-supplementation-with-bovine-colostrum-prevents-septic-shock-and-brain-barrier-disruption-during-bloodstream-infection-in-preterm-newborn-pigs
#6
Anders Brunse, Päivi Worsøe, Susanne Elisabeth Pors, Kerstin Skovgaard, Per Torp Sangild
Preterm infants have increased risk of neonatal sepsis, potentially inducing brain injury, and they may benefit from early initiation of enteral milk feeding. Using preterm pigs as models, we hypothesized that early provision of bovine colostrum to parentally nourished newborns protects against sepsis and neuroinflammation during bloodstream infection. Preterm newborn pigs were administered 10 CFU/kg of intra-arterial Staphylococcus epidermidis (SE, an opportunistic pathogen often causing sepsis in preterm infants), followed by administration of total parenteral nutrition (TPN, SE + TPN, n = 15) or oral provision of bovine colostrum with supplementary parenteral nutrition (SE + COL, n = 14), and compared with uninfected, TPN-nourished controls (CON + TPN, n = 11)...
February 21, 2018: Shock
https://www.readbyqxmd.com/read/29468780/efficacy-analysis-of-routine-catheter-tip-cultures-in-a-neonatal-intensive-care-unit
#7
Taito Kitano, Kumiko Takagi, Ikuyo Arai, Hajime Yasuhara, Reiko Ebisu, Ayako Ohgitani, Daisuke Kitagawa, Miyako Oka, Kazue Masuo, Hideki Minowa
OBJECTIVES: Although routine catheter tip cultures are not recommended, previous reports have indicated that some cases of colonization, such as with S. aureus, can lead to subsequent bacteremia. To evaluate the safety of colonized cases without antimicrobial treatment, as well as the effectiveness of routine catheter tip cultures in the neonatal intensive care unit (NICU), we performed a retrospective data analysis in a Japanese community hospital. METHODS: We reviewed all peripherally inserted central venous catheter tip culture results from the NICU ward between April 2012 and June 2017 to determine whether they had antimicrobial treatments or subsequent infections...
February 22, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29468633/prostaglandin-gel-versus-oxytocin-prelabour-rupture-of-membranes-at-term-a-randomised-controlled-trial
#8
Kassam Mahomed, Kellie Wild, Christopher R Weekes
BACKGROUND: Pre-labour rupture of membranes (PROM) at term is a common event with early induction of labour reducing infectious morbidity without increasing the caesarean rate. Syntocinon is commonly used for induction but prostaglandins are also routinely used. Large studies have shown no difference in the maternal and neonatal outcomes with either method. AIM: To assess the safety and efficacy of vaginal prostaglandin (PG) compared to syntocinon for induction of labour in term-PROM...
February 22, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29467722/high-incidence-of-pathogenic-streptococcus-agalactiae-st485-strain-in-pregnant-puerperal-women-and-isolation-of-hyper-virulent-human-cc67-strain
#9
Liping Li, Rui Wang, Yan Huang, Ting Huang, Fuguang Luo, Weiyi Huang, Xiuying Yang, Aiying Lei, Ming Chen, Xi Gan
Group B streptococcus (GBS) is the major pathogen causing diseases in neonates, pregnant/puerperal women, cows and fish. Recent studies have shown that GBS may be infectious across hosts and some fish GBS strain might originate from human. The purpose of this study is to investigate the genetic relationship of CC103 strains that recently emerged in cows and humans, and explore the pathogenicity of clinical GBS isolates from human to tilapia. Ninety-two pathogenic GBS isolates were identified from 19 patients with different diseases and their evolution and pathogenicity to tilapia were analyzed...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29467596/cost-effectiveness-of-antiviral-prophylaxis-during-pregnancy-for-the-prevention-of-perinatal-hepatitis-b-infection-in-south-korea
#10
Donghoon Lee, Hyun-Young Shin, Sang Min Park
Background: In Korea, hepatitis B virus (HBV) infection accounts for approximately 65-75% of HBV-related diseases, such as chronic hepatitis and liver cancer, and mother-to-child transmission is presumed to be a major source of the infection. To tackle this issue, the Korean government launched the national Perinatal Hepatitis B Prevention Program (PHBPP) in 2002. This study analyzed the cost-effectiveness of the PHBPP with antiviral prophylaxis compared with the current PHBPP and/or universal vaccination, as well as identified the optimal strategy to eliminate mother-to-child transmission of HBV in Korea...
2018: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/29465747/antibiotics-for-treating-gonorrhoea-in-pregnancy
#11
REVIEW
Gabriella Comunián-Carrasco, Guiomar E Peña-Martí, Arturo J Martí-Carvajal
BACKGROUND: Gonorrhoea is a sexually transmitted infection that is caused by Neisseria gonorrhoeae, and is a major public health challenge today. N gonorrhoeae can be transmitted from the mother's genital tract to the newborn during birth, and can cause gonococcal ophthalmia neonatorum as well as systemic neonatal infections. It can also cause endometritis and pelvic sepsis in the mother. This review updates and replaces an earlier Cochrane Review on antibiotics for treating this infectious condition...
February 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29463335/safety-of-palivizumab-stewardship-in-conjunction-with-infection-prevention-and-control-strategies-for-healthcare-associated-respiratory-syncytial-virus-infections
#12
Rupal M Patel, Larry K Kociolek, Emily Merrick, Caroline Reuter, Kenny Kronforst, Xiaotian Zheng, Sameer J Patel
Transitioning from administration of monthly palivizumab to a single dose at discharge was associated with substantial pharmacy cost savings. With the concurrent adoption of private hospital rooms and visitor restriction policies, hospital-wide and neonatal intensive care unit healthcare-associated respiratory syncytial virus infections decreased following these changes. Infect Control Hosp Epidemiol 2018;1-4.
February 21, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29463305/lysozyme-improves-gut-performance-and-protects-against-enterotoxigenic-escherichia-coli-infection-in-neonatal-piglets
#13
Guangping Huang, Xiangqing Li, Dan Lu, Shen Liu, Xun Suo, Qiuyan Li, Ning Li
Diarrhea remains one of the leading causes of morbidity and mortality globally, with enterotoxigenic Escherichia coli (ETEC) constituting a major causative pathogen. The development of alternative treatments for diarrhea that do not involve chemotherapeutic drugs or result in antibiotic resistance is critical. Considering that lysozyme is a naturally occurring antimicrobial peptide, in a previous study we developed a transgenic pig line that expresses recombinant human lysozyme (hLZ) in its milk. In the present study, we examined the protective effects of the consumption of this milk against ETEC infection in neonatal piglets...
February 20, 2018: Veterinary Research
https://www.readbyqxmd.com/read/29463283/neonatal-diagnosis-of-isolated-absence-of-the-right-pulmonary-artery-a-case-report-and-review-of-the-literature
#14
Akamin Raymond, Ettore Pedretti, Giuseppina Privitera, Cristina Cicero, Giacomo Biasucci
BACKGROUND: Unilateral absence of the pulmonary artery (UAPA) is a rare congenital malformation often associated with other cardiac anomalies; however it may occur as an isolated lesion. Isolated absence of the right pulmonary artery is twice more frequent than that of the left pulmonary artery. Patients with isolated UAPA are usually asymptomatic at birth; thereafter they may develop a progression of symptoms such as exercise intolerance, dyspnea, chest pain, hemoptysis and recurrent pulmonary infections...
February 20, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29460716/role-of-wild-type-and-recombinant-human-t-cell-leukemia-viruses-in-lymphoproliferative-disease-in-humanized-nsg-mice
#15
Devra D Huey, Brad Bolon, Krista M D La Perle, Priya Kannian, Steven Jacobson, Lee Ratner, Patrick L Green, Stefan Niewiesk
Chronic infection with human T-cell leukemia virus type 1 (HTLV1) can lead to adult T-cell leukemia (ATL). In contrast, infection with HTLV2 does not lead to leukemia, potentially because of distinct virus-host interactions and an active immune response that controls virus replication and, therefore, leukemia development. We created a humanized mouse model by injecting human umbilical-cord stem cells into the livers of immunodeficient neonatal NSG mice, resulting in the development of human lymphocytes that cannot mount an adaptive immune response...
February 1, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29460549/igm-and-iga-enriched-polyclonal-immunoglobulins-reduce-short-term-mortality-in-extremely-low-birth-weight-infants-elbw-with-sepsis-a-retrospective-cohort-study
#16
Letizia Capasso, Angela C Borrelli, Maria R Pirozzi, Laura Bucci, Roberta Albachiara, Teresa Ferrara, Francesco Raimondi
BACKGROUND: Immunoglobulin supplementation is a debated strategy in fighting sepsis. We evaluated a polyclonal IgM and IgA enriched immunoglobulin (IgMeIVIG) preparation in reducing the short term mortality in extremely low birth weight neonates (ELBW) with proven infection. METHODS: ELBW infants born from January 2008 to December 2014 were eligible for this retrospective casecontrol analysis if they were symptomatic and had a positive blood culture after 72hours of life...
February 19, 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29459579/neonatal-leukemoid-reaction-with-fetal-inflammatory-response-syndrome-is-associated-with-elevated-serum-granulocyte-colony-stimulating-factor-and-interleukin-6
#17
Toshihiko Nakamura, Daisuke Hatanaka, Michiko Kusakari, Kohei Kashima, Yuji Takizawa, Hidehiro Takahashi, Toshiro Yoshioka, Naoto Takahashi, Takashi Kamohara
Leukemoid reaction (LR) is a reactive disease that exhibits abnormal blood values similar to leukemia, but not due to leukemia. One report showed that neonatal LR (NLR) was associated with elevated serum granulocyte colony stimulating factor (G-CSF) in only 30% of the study neonates. NLR is not always associated with the elevation of serum G-CSF. NLR was defined as a white blood cell count of ≥ 40 × 103 /μL and/or blast cell concentration of > 2%. We have focused on NLR with fetal inflammatory response syndrome (FIRS), defined as a fetal systemic inflammatory reaction triggered by intrauterine infection...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29458556/sequence-analysis-of-the-g-gene-of-hrsva-on1-genotype-from-egyptian-children-with-acute-respiratory-tract-infections
#18
Ahmed S Abdel-Moneim, May S Soliman, Mahmoud M Kamel, Amani A El-Kholy
Human respiratory syncytial virus causes severe lower respiratory tract infection in neonates and children. Genotype ON1, with duplication of 72-nt in the G gene, was first detected in Canada and then recorded in other countries. In the current study, we describe the first detection of the ON1 genotype among children in Egypt in 2014/2015. Sequence analysis of the full-attachment G gene revealed that the majority of the strains examined were related to the ON1 genotype and only one sample related to N1 genotype...
February 2, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29458133/artesunate-derived-monomeric-dimeric-and-trimeric-experimental-drugs-their-unique-mechanistic-basis-and-pronounced-antiherpesviral-activity
#19
Friedrich Hahn, Tony Fröhlich, Theresa Frank, Luca D Bertzbach, Stephan Kohrt, Benedikt B Kaufer, Thomas Stamminger, Svetlana B Tsogoeva, Manfred Marschall
Human cytomegalovirus (HCMV) is a major human pathogen and is associated with severe pathology, such as life-threatening courses of infection in immunocompromised individuals and neonates. Currently, antiviral therapy is still hampered by a considerable toxicity of the available drugs and induction of viral resistance. Recently, we and others reported the very potent antiviral activity of the broad antiinfective drug artesunate in vitro and in vivo. Here, we investigated further optimized analogs including monomeric, dimeric and trimeric derivatives belonging to this highly interesting chemical group of experimental drugs (sesquiterpenes/trioxanes) and compared these to the previously identified trimeric artesunate compound TF27...
February 16, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29456562/colonization-with-hospital-flora-and-its-associated-risk-factors-in-neonates-hospitalized-in-neonatal-ward-of-a-teaching-center-in-isfahan-iran
#20
Kiana Shirani, Kamyar Mostafavizadeh, Behrouz Ataei, Khatere Akhani
Background: Due to the high incidence and prevalence of infection in neonatal ward, especially Neonatal Intensive Care Units (NICUs) reported by different studies and the important role of colonization with hospital germs in the development of nosocomial infections, we intended to evaluate the risk of colonization with hospital germs in neonates and its associated risk factors. Materials and Methods: This cross-sectional, descriptive-analytical study was conducted in 2016 in a Teaching Center in Iran...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
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