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"Diabetes type I"

Federico Wadehn, Stephan Schaller, Thomas Eissing, Markus Krauss, Lars Kupfer, Federico Wadehn, Stephan Schaller, Thomas Eissing, Markus Krauss, Lars Kupfer, Federico Wadehn, Markus Krauss, Lars Kupfer, Stephan Schaller, Thomas Eissing
A multiscale model for blood glucose regulation in diabetes type I patients is constructed by integrating detailed metabolic network models for fat, liver and muscle cells into a whole body physiologically-based pharmacokinetic/pharmacodynamic (pBPK/PD) model. The blood glucose regulation PBPK/PD model simulates the distribution and metabolization of glucose, insulin and glucagon on an organ and whole body level. The genome-scale metabolic networks in contrast describe intracellular reactions. The developed multiscale model is fitted to insulin, glucagon and glucose measurements of a 48h clinical trial featuring 6 subjects and is subsequently used to simulate (in silico) the influence of geneknockouts and drug-induced enzyme inhibitions on whole body blood glucose levels...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Patrick Goetti, Nicolas Gallusser, Olivier Borens
Diabetic osteoarthropathy is a rare cause of neuropathic joint disease of the knee; bilateral involvement is even more exceptional. Diagnosis is often made late due to its unspecific symptoms and appropriate surgical management still needs to be defined, due to lack of evidence because of the disease's low incidence. We report the case of a forty-year-old woman with history of diabetes type I who developed bilateral destructive Charcot knee arthropathy. Bilateral total knee arthroplasty was performed in order to achieve maximal functional outcome...
2016: Case Reports in Orthopedics
Rasoul Baharlou, Abbas Ahmadi-Vasmehjani, Mohammad Hasan Davami, Fatemeh Faraji, Mohammd Reza Atashzar, Firoozeh Karimipour, Alireza Sadeghi, Mohammad-Ali Asadi, Mahshid Khoubyari
BACKGROUND: Type 1 diabetes (T1D) is thought to involve chronic inflammation, which is manifested by the activation and expression of different inflammatory mediators. Th1- and Th17-associated cytokines are factors that have been shown to exert profound pro-inflammatory activities and have been implicated in the pathogenesis of T1D in mice and humans. OBJECTIVES: Therefore, the aim of this case control study was to determine the serum level of IL-17, IL-21, IL-27, transforming growth factor beta (TGF-β), and IFN-γ and their reciprocal relationship in Iranian T1D patients...
October 2016: Immunological Investigations
Yogesh A Kulkarni, Mayuresh S Garud
Among various metabolic disorders, diabetes mellitus is one of the most common disorder. Present study was designed to evaluate the effectiveness of aqueous extract of Bauhinia variegata leaves (AE) in animal models of type I and type II diabetes. Type I diabetes was induced by streptozotocin at the dose of 55mg/kg (i.p.) in male Sprague Dawley rats while type II diabetes was induced by high fat diet and streptozotocin at the dose of 35mg/kg (i.p.). Diabetic animals were treated with AE at the dose of 250, 500 and 1000mg/kg...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Isabel Ruiz-González, Manuel Fernández-Alcántara, Trinidad Guardia-Archilla, Sonia Rodríguez-Morales, Angeles Molina, Dolores Casares, Macarena De Los Santos-Roig
OBJECTIVE: The purpose of this study was to implement an intensive and practical diabetes education program (DEP) and evaluate its long-term effects and its impact on psychosocial variables. It was hypothesized that the DEP would improve patients' metabolic control (A1c hemoglobin - HbA1c), technical knowledge, self-efficacy and frequency of self-care and decrease barriers and other parameters such as the body mass index (BMI) and LDL cholesterol. These results should be maintained at one-year follow-up...
August 2016: Applied Nursing Research: ANR
Daphna Katz, Itay Katz, Amir Golan
Medical uses of Cannabis sativa have been known for over 6,000 years. Nowadays, cannabis is mostly known for its psychotropic effects and its ability to relieve pain, even though there is evidence of cannabis use for autoimmune diseases like rheumatoid arthritis centuries ago. The pharmacological therapy in autoimmune diseases is mainly based on immunosuppression of diffefent axes of the immune system while many of the drugs have major side effects. In this review we set out to examine the rule of Cannabis sativa as an immunomodulator and its potential as a new treatment option...
February 2016: Harefuah
Luiz Flavio Andrade, Thomas Rapp, Christine Sevilla-Dedieu
BACKGROUND: Diabetes is today a major public health concern in terms of its financial and social burden. Previous studies have revealed that specialist care for patients with diabetes leads to more positive outcomes than care by general practitioners (GPs) alone. The aim of this study was to estimate the determinants of endocrinologist consultation by patients with diabetes. METHODS: We used a two-part model to explore both the decision to consult and the frequency of consultations...
December 2016: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
Rajani Gupta, Kaushik Bhar, Nandini Sen, Debajit Bhowmick, Satinath Mukhopadhyay, Koustubh Panda, Anirban Siddhanta
Diabetes (Type I and Type II) which affects nearly every organ in the body is a multi-factorial non-communicable disorder. Hyperglycemia is the most characteristic feature of this disease. Loss of beta cells is common in both types of diabetes whose detailed cellular and molecular mechanisms are yet to be elucidated. As this disease is complex, identification of specific biomarkers for its early detection, management and devising new therapies is challenging. Based on the fact that functionally defective proteins provide the biochemical basis for many diseases, in this study, we tried to identify differentially expressed proteins during hyperglycemia...
February 2016: Indian Journal of Experimental Biology
Salman Khan, Ran Joo Choi, Joohee Lee, Yeong Shik Kim
The present study investigated the neuropathic pain, anti-neuroinflammatory and neuroprotective properties of a pyranocoumarin derivative (anomalin) in in vivo and in vitro models. An in vivo streptozotocin (STZ)-induced diabetic neuropathic pain model demonstrated that anomalin significantly suppressed neuropathic pain in mice. To identify the molecular mechanism of the anti-neuropathic pain activity of anomalin, sodium-nitroprusside (SNP)-induced neuroinflammation in neuro-2a (N2a) cells was further investigated in signaling pathways...
March 5, 2016: European Journal of Pharmacology
Bianca M Buurman, Wijnanda J Frenkel, Ameen Abu-Hanna, Juliette L Parlevliet, Sophia E de Rooij
BACKGROUND: To describe the prevalence of multimorbidity and to study the association between acute and chronic diseases in acutely hospitalized older patients METHODS: Prospective cohort study conducted between 2006 and 2008 in three teaching hospitals in the Netherlands. 639 patients aged 65 years and older, hospitalized for >48 h were included. Two physicians scored diseases, using ICD-9 codes. Chronic multimorbidity was defined as the presence of ≥2 chronic diseases, and acute multimorbidity as ≥1 acute diseases upon pre-existent chronic diseases...
January 2016: European Journal of Internal Medicine
Steen G Stahlhut, Solvej Siedler, Sailesh Malla, Scott J Harrison, Jérôme Maury, Ana Rute Neves, Jochen Forster
Plant secondary metabolites are an underutilized pool of bioactive molecules for applications in the food, pharma and nutritional industries. One such molecule is fisetin, which is present in many fruits and vegetables and has several potential health benefits, including anti-cancer, anti-viral and anti-aging activity. Moreover, fisetin has recently been shown to prevent Alzheimer's disease in mice and to prevent complications associated with diabetes type I. Thus far the biosynthetic pathway of fisetin in plants remains elusive...
September 2015: Metabolic Engineering
M A Javidi, F Zolghadr, S Babashah, M Sadeghizadeh
One of the major obstacles needed to be overcome before using cell therapy for clinical purposes is the high probability of tumor formation in patients who receive the transplants, as undifferentiated stem cells (SCs) have the potential to form teratomas/teratocarcinoma in xenotransplants. In this study the ability of dendrosomal nanocurcumin (solublized curcumin using a biodegradable non-toxic nano-carrier) to affect undifferentiated/hazardous cell, and hence increasing the safety of cell therapy (particularly in diabetes type I) by mesenchymal stem cells (MSCs) was examined...
November 2015: Experimental and Clinical Endocrinology & Diabetes
Nina Joyce, Gregory A Wellenius, David D Dore, Jane W Newburger, Justin P Zachariah
OBJECTIVES: Pediatric guidelines in 2008 and 2011 recommended lipid lowering therapy in children ≥ 8 years of age with high-risk cardiovascular conditions, such as familial hypercholesterolemia (FH). Our objective was to describe the patterns and predictors of lipid lowering therapy initiation in commercially insured children between 2005 and 2010. STUDY DESIGN: Using commercial health plan data on children ages 8-20 years from 2004-2010, we estimated rates of lipid lowering therapy initiation overall and stratified by age...
July 2015: Journal of Pediatrics
Ann-Marie Liljeroth, Ann-Charlotte Palm, Helene Holmer
Cognitive decline is well known to be connected to diabetes in presence of repetitive hyper- as well as hypoglycemia. At the Memory Clinic at CSK, Kristianstad, we have observed over 40 patients with cognitive decline and diabetes type I and II. Cognitive dysfunction seems to affect both compliance and the glucose levels. In collaboration with the diabetes unit at the Medicine Clinic, CSK, guidelines have been developed to aid early discovery of cognitive decline and adapted interventions aiming for optimal independence at home and at work...
2015: Läkartidningen
Y Aghajanova, H Harutyunyan, L Mkrtchyan, M Aghajanov
Restoration of beta cell functional activity is a cracial in diabetes type I treatment. Earlier, we have shown that embryonal antitumor modulator, created by prof. L. Mkrtchyan (EATM), expresses protective activity in rat diabetes model. In the present study, we sought to evaluate whether EATM directly acts on beta cell and protects them from streptozotocin (STZ) induced damage in primary mouse and human pancreatic beta cell cultures. Beta cells were isolated by treatment of whole pancreas (mouse) or piece of pancreatic tissue (human) with collagenase and trypsine...
November 2014: Georgian Medical News
J Krásný, J Vosáhlo, J Celedová, I Hora, L Magera, M Veith
AIM: To evaluate the development of retinal changes in adolescent patients with diabetes type I (T1DM) with diseases duration more than 10 years, which started before 5 years of age. METHODS: The development of the findings on the posterior pole was followed up. The retinal functions were established by means of contrast sensitivity in four space frequencies: 3 cycles/degree (c/deg) (perimacular area), 6 c/deg and 12 c/deg (macular area), and, finally, 18 c/deg (foveola)...
2014: Ceská a Slovenská Oftalmologie
Ganna M Shayakhmetova, Larysa B Bondarenko, Anatoliy V Matvienko, Valentina M Kovalenko
PURPOSE: The aim of the study was to investigate the correlation between spermatogenesis disorders and CYP2E1 mRNA contents in testes of rats with experimental alcoholism or type I diabetes. MATERIAL/METHODS: Two pathological states characterized by CYP2E1 induction were simulated on Wistar male rats: experimental alcoholism and type I diabetes. As controls for each state, equal number of animals (of the same age and weight) were used. Morphological evaluation of rat testes was carried out...
September 2014: Advances in Medical Sciences
Willem van Eden
Stress proteins or heat shock proteins (HSPs) have a critical role in gut health and immune regulation. They have a functional significance as molecular chaperones for cell skeleton proteins and intercellular tight junction proteins. Herewith HSPs ensure gut epithelium integrity and effective intestinal barrier function. In addition, stress protein molecules such as HSP70 are a target for anti-inflammatory regulatory T cells (Tregs). Inflamed sites in the body feature inflammatory-stress induced enhanced levels of HSPs, which enable the immune system to target Tregs selectively to sites of inflammation...
2015: Endocrine, Metabolic & Immune Disorders Drug Targets
Thorsten Meißner, Elke Eckelt, Tina Basler, Jochen Meens, Julia Heinzmann, Abdulhadi Suwandi, Walter M R Oelemann, Sandra Trenkamp, Otto Holst, Siegfried Weiss, Boyke Bunk, Cathrin Spröer, Gerald-F Gerlach, Ralph Goethe
Mycobacterium avium subspecies paratuberculosis (MAP) causes Johne's disease, a chronic granulomatous enteritis in ruminants. Furthermore, infections of humans with MAP have been reported and a possible association with Crohn's disease and diabetes type I is currently discussed. MAP owns large sequence polymorphisms (LSPs) that were exclusively found in this mycobacteria species. The relevance of these LSPs in the pathobiology of MAP is still unclear. The mptD gene (MAP3733c) of MAP belongs to a small group of functionally uncharacterized genes, which are not present in any other sequenced mycobacteria species...
2014: Frontiers in Cellular and Infection Microbiology
Gamal Allam, Adnan A Alsulaimani, Hamed Alghamdi, Hameed Alswat, Burhan M Edrees, Iftikhar Ahmad, Amre Nasr
The aim of the present study was to investigate the possible effects of living in moderate altitude area on pro/anti-inflammatory cytokines profile (IFN-γ, TNF-α, IL-6, IL-1β, IL-10, and IL-4) among type I diabetic (T1D) and non- T1D children compared with those living at sea level area. A prospective clinical study was carried out at pediatric outpatient endocrine clinics in Taif City, which is a moderate altitude area in Saudi Arabia, that stands about 1800-2000 meters above sea-level; and in Mecca City, which is a sea level area, that lies in the middle west of Saudi Arabia...
September 2014: High Altitude Medicine & Biology
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