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https://www.readbyqxmd.com/read/28944554/limited-potential-of-cebranopadol-to-produce-opioid-type-physical-dependence-in-rodents
#1
Thomas M Tzschentke, Babette Y Kögel, Stefanie Frosch, Klaus Linz
Cebranopadol is a novel potent analgesic agonist at the nociceptin/orphanin FQ peptide (NOP) and classical opioid receptors. As NOP receptor activation has been shown to reduce side effects related to the activation of μ-opioid peptide (MOP) receptors, the present study evaluated opioid-type physical dependence produced by cebranopadol in mice and rats. In a naloxone-precipitated withdrawal assay in mice, a regimen of seven escalating doses of cebranopadol over 2 days produced only very limited physical dependence as evidenced by very little withdrawal symptoms (jumping) even at cebranopadol doses clearly exceeding the analgesic dose range...
September 25, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28944156/peripheral-ischaemic-retinopathy-and-neovascularisation-in-a-patient-with-subacute-streptococcus-mitis-induced-bacterial-endocarditis
#2
Laura S Leysen, Elke O Kreps, Ilse De Schryver, Kristien P Hoornaert, Vanessa Smith, Julie De Zaeytijd
Objective: To describe a patient with peripheral retinal ischaemia and neovascularisation who was diagnosed with streptococcus mitis-induced bacterial endocarditis. Methods: Retrospective analysis of case report. A 57-year-old man presented with a history of a rapidly progressive, bilateral, painless visual loss. He also suffered from pain in the neck and lower back and a weight loss of 10 kg. He underwent a full ophthalmologic work-up, laboratory investigations, and imaging of the spine. Results: BCVA was reduced to 20/40 in the right eye and 20/32 in the left eye...
2017: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/28943595/subacute-left-atrial-thrombus-formation-after-percutaneous-edge-to-edge-mitral-valve-repair-for-functional-mitral-regurgitation
#3
Makoto Amaki, Yu Kataoka, Hideaki Kanzaki, Koji Miyamoto, Atsushi Okada, Yasuhiro Hamatani, Masashi Fujino, Hiroyuki Takahama, Takuya Hasegawa, Yasuo Sugano, Kengo Kusano, Yoshihiko Ohnishi, Tomoyuki Fujita, Junjiro Kobayashi, Toshihisa Anzai, Satoshi Yasuda
No abstract text is available yet for this article.
September 22, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28942661/-etanercept-induced-subacute-thyroiditis-case-report-and-literature-review
#4
Zoltán Hella, László Hodinka, Piroska Turbucz, Gábor László Kovács
65 years old male patient received 4 mg/day methylprednisolone baseline therapy and 50 mg/week etanercept treatment for 5 years due to rheumatoid arthritis. The patient experienced pain in neck, and developed weakness, fever and dysphagia. He had normal blood count but accelerated erythrocyte sedimentation rate (88 mm/hour), elevated CRP (49.3 mg/l) and hyperthyroidism (TSH 0.006 mIU/l, fT4 27.22 pmol/l, fT3 5.61 pmol/l). The autoimmune origin could be excluded because of normal values of antibodies against thyreoidea peroxidase and TSH receptor...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28941497/cutaneous-lupus-a-brief-review-of-old-and-new-medical-therapeutic-options
#5
REVIEW
Fnu Nutan, Alex G Ortega-Loayza
Systemic lupus erythematosus is a chronic inflammatory condition which affects predominantly women in their 30s. It has several clinical manifestations, including skin lesions that can be classified as acute cutaneous lupus erythematosus, subacute cutaneous lupus erythematosus, and chronic cutaneous lupus erythematosus. A multifaceted approach to treating cutaneous lupus is advocated.
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28940429/is-real-time-elastography-helpful-to-differentiate-acute-from-subacute-deep-venous-thrombosis-a-preliminary-study
#6
Ahmet Aslan, Hakan Barutca, Ercan Ayaz, Mine Aslan, Cemal Kocaaslan, Ibrahim Inan, Sinan Sahin, Ali Yıkılmaz
PURPOSE: To detect and characterize changes in stiffness of thrombus in patients with acute and subacute deep venous thrombosis (DVT) by using real-time elastography (RTE). METHODS: Fifty-eight patients with acute or subacute DVT were prospectively evaluated by B-mode sonography (US), color Doppler US (CDUS), and RTE. Two radiologists evaluated the thrombus echogenicity, compressibility, and recanalization of the affected vein, and thrombus stiffness in consensus...
September 22, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28940367/subacute-cutaneous-lupus-erythematosus-induced-by-masitinib
#7
Daniel Nieto-Rodríguez, Cristina Gómez-Fernández, José Manuel Rueda-Carnero, Pedro Herranz-Pinto
No abstract text is available yet for this article.
September 22, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28936607/time-of-flight-mr-angiography-in-cerebral-venous-sinus-thrombosis
#8
Dimitri Renard, Emmanuelle Le Bars, Caroline Arquizan, Nicolas Gaillard, Nicolas Menjot de Champfleur, Isabelle Mourand
Recently, time-of-flight (TOF) and gadolinium-enhanced MR angiography (MRA) imaging have been used to demonstrate subacute intramural hematoma in cervical artery dissection and to detect intraplaque haemorrhage. Our aim was to perform an exploratory study to analyse if venous thrombus-related signal changes (potentially showing iso- or hyperintensity) in cerebral venous sinus thrombosis (CVST) could be observed on 3D-TOF MRA imaging. We analysed retrospectively MRIs of CVST patients in whom both contrast-enhanced MR venography (CEMRV) and 3D-TOF sequences were performed in the acute/subacute phase (i...
September 21, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28936376/bacterial-endocarditis-presenting-as-leukocytoclastic-vasculitis
#9
Sarah El Chami, Atieh Jibbe, Shadi Shahouri
Subacute bacterial endocarditis can have many different presentations; in rare instances, it can present as leukocytoclastic vasculitis owing to the effect of circulating immune complexes and micro-emboli on the vascular endothelium. A high index of suspicion needs to be maintained to differentiate between infectious vs noninfectious autoimmune vasculitides, keeping in mind that missing a diagnosis can have fatal results. In this case report, we introduce a young female patient who initially presented with a picture of idiopathic autoimmune cutaneous vasculitis delaying the diagnosis of an underlying infective endocarditis with aortic valve involvement...
July 13, 2017: Curēus
https://www.readbyqxmd.com/read/28936083/unilateral-papilledema-in-cerebral-venous-sinus-thrombosis
#10
Girish Baburao Kulkarni, Ravinder Jeet Singh, Veeranna Gadad, Subasree Ramakrishnan, Veerendrakumar Mustare
In the majority of patients with raised intracranial pressure, the papilledema is bilateral. Unilateral papilledema is rare in conditions causing intracranial hypertension, and it has been described in Foster-Kennedy syndrome and in some cases of idiopathic intracranial hypertension. It has never been reported in cerebral venous thrombosis. We report a young lady presenting with features of subacute onset of headache with seizures, on evaluation she had superior sagittal and bilateral lateral sinus thrombosis...
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28936075/headache-patterns-in-cerebral-venous-sinus-thrombosis
#11
Ragasudha Botta, Sheshagiri Donirpathi, Ravi Yadav, Girish B Kulkarni, M Veerendra Kumar, Dindigur Nagaraja
OBJECTIVES: The objective of this study was to assess the clinical characteristics, patterns, and factors associated with headache in patients with cerebral venous sinus thrombosis (CVT). METHODS: In this prospective cohort study, we recruited conscious CVT patients who were able to give reliable history after consent. Institutional ethics approval was obtained. The diagnosis of CVT was based on the clinical and imaging parameters. Data regarding headache characteristic, severity (visual analog scale [VAS]), imaging findings and outcome was recorded...
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28936074/syndromes-of-rapidly-progressive-cognitive-decline-our-experience
#12
Sadanandavalli Retnaswami Chandra, Lakshminarayanapuram Gopal Viswanathan, Anupama Ramakanth Pai, Rahul Wahatule, Suvarna Alladi
BACKGROUND: Dementias are fairly slowly progressive degenerative diseases of brain for which treatment options are very less and carry a lot of burden on family and society. A small percentage of them are rapidly progressive and mostly carry a different course outcome. However, there are no definite criteria other than the time line for these patients. AIMS: The aim of this was to identify and categorize the causes and course of rapidly progressive dementias seen in our center...
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28935172/a-pediatric-case-with-peripheral-facial-nerve-palsy-caused-by-a-granulomatous-lesion-associated-with-cat-scratch-disease
#13
Chizuko Nakamura, Yuji Inaba, Keiko Tsukahara, Mie Mochizuki, Emi Sawanobori, Yozo Nakazawa, Kouki Aoyama
BACKGROUND: Cat scratch disease is a common infectious disorder caused by Bartonella henselae that is transmitted primarily by kittens. It typically exhibits a benign and self-limiting course of subacute regional lymphadenopathy and fever lasting two to eight weeks. The most severe complication of cat scratch disease is involvement of the nervous system, such as encephalitis, meningitis, and polyneuritis. Peripheral facial nerve palsy associated with Bartonella infection is rare; few reported pediatric and adult cases exist and the precise pathogenesis is unknown...
September 18, 2017: Brain & Development
https://www.readbyqxmd.com/read/28935071/clinical-angiographic-and-procedural-correlates-of-acute-subacute-and-late-absorb-scaffold-thrombosis
#14
Stephen G Ellis, Giuseppe Steffenino, Dean J Kereiakes, Gregg W Stone, R J van Geuns, Alexandre Abizaid, Holger Nef, Bernardo Cortese, Luca Testa, Maurizio Menichelli, Corrado Tamburino, Tommaso Gori, Takeshi Kimura, Patrick W Serruys, Salvatore Brugaletta, Manel Sabaté, Run-Lin Gao
OBJECTIVES: The authors sought to identify and verify independent correlates of device thrombosis from an analysis of multicenter trials and registries. BACKGROUND: Recent analyses suggest an increased risk of device thrombosis with Absorb bioresorbable vascular scaffold (Abbott Vascular, Santa Clara, California) implantation compared with metallic drug-eluting stents, and data from moderate size studies suggest a risk relationship to vessel size and technique. METHODS: From 8,771 consecutively treated patients, 105 patients (1...
September 25, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28933363/the-spectrum-of-neurological-manifestations-associated-with-gaucher-disease
#15
REVIEW
Tamanna Roshan Lal, Ellen Sidransky
Gaucher disease, the most common lysosomal storage disorder, is due to a deficiency in the enzyme glucocerebrosidase. This leads to the accumulation of its normal substrate, glucocerebroside, in tissue macrophages, affecting the hematological, visceral, bone and neurologic systems. Gaucher disease is classified into three broad phenotypes based upon the presence or absence of neurological involvement: type 1 (non-neuronopathic), type 2 (acute neuronopathic), and type 3 (subacute neuronopathic). Phenotypically, there is a wide spectrum of visceral and neurological manifestations...
March 2, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/28933223/genetic-and-histological-alterations-reveal-key-role-of-prostaglandin-synthase-and-cyclooxygenase-1-and-2-in-traumatic-brain-injury-induced-neuroinflammation-in-the-cerebral-cortex-of-rats-exposed-to-moderate-fluid-percussion-injury
#16
Hideki Shojo, Cesario V Borlongan, Tadashi Mabuchi
After the initial insult in traumatic brain injury (TBI), secondary neurodegeneration occurs that is intimately associated with neuroinflammation. Prostaglandin (PG) synthases and cyclooxygenase (COX) 1 and 2 may contribute to inflammation in the brain. Temporal and spatial expression features of PG and COX1 and 2 following trauma may guide the development of antineuroinflammation strategies. Here, we examined PG synthase signaling and COX1 and 2 gene expression levels and COX-1- and 2-positive cell types and their temporal localization in TBI-induced brain in an effort to reveal their participation in the disease's evolving neuroinflammation...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28933220/elucidation-of-gene-expression-patterns-in-the-brain-after-spinal-cord-injury
#17
Ahreum Baek, Sung-Rae Cho, Sung Hoon Kim
Spinal cord injury (SCI) is a devastating neurological disease. The pathophysiological mechanisms of SCI have been reported to be relevant to central nervous system injury such as brain injury. In this study, gene expression of the brain after SCI was elucidated using transcriptome analysis to characterize the temporal changes in global gene expression patterns in a SCI mouse model. Subjects were randomly classified into 3 groups: sham control, acute (3 h post-injury), and subacute (2 wk post-injury) groups...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28932040/a-rare-coexistence-of-aspergillosis-with-actinomycosis
#18
B Hari Vinay, Aditya Mohan, P Haritha, K Roja Lakshmi
Aspergillosis is a common systemic mycosis which affects immunocompromised and immunocompetent hosts. Aspergillus spp. is wide spread in the environment in most countries, which renders an invasive form of disease. The presence conidial heads are pathognomic to aspergillosis in diagnosis. Actinomycosis is a subacute-to-chronic infection that causes sinus fistula, tract or abscess due to the invasion surrounding the soft tissue. Cervicofacial infection accounts for 50%-60% of all actinomycosis cases. The mandible and nasopharynx are the sites of predilection, but maxillary infection is rare...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28931983/postactivation-depression-of-soleus-h-reflex-increase-with-recovery-of-lower-extremities-motor-functions-in-patients-with-subacute-stroke
#19
Yu Kawaishi, Naoki Matsumoto, Toshiya Nishiwaki, Tatsuro Hirano
[Purpose] The soleus H-reflex is depressed at stimulation rates greater than 0.1 Hz. This reflex depression is referred to as postactivation depression. Postactivation depression reflects the reduced efficacy of the Ia-motoneurons synapses when they are evaluated after a previous activation. The aim of this study was to determine whether the recovery of motor functions in the lower extremities affects the PAD of the soleus H-reflex in patients with subacute stroke undergoing rehabilitation. [Subjects and Methods] Eight patients with subacute stroke patients were recruited...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28929275/current-pesticide-dietary-risk-assessment-in-light-of-comparable-animal-study-noaels-after-chronic-and-short-termed-exposure-durations
#20
Jürg A Zarn, Caitlyn D O'Brien
Dietary risk assessment (DRA) of pesticides includes the estimation of chronic and acute exposures from crop residues, but assesses acute exposures only for pesticides with an acute reference dose (ARfD). Acute estimation uses high percentiles of food consumption surveys which are considerably higher than per capita lifetime averaged food consumption values which are used for chronic estimations. Assessing acute risks only for pesticides with an ARfD tacitly assumes that chronic risk assessment covers also intermittent occurring exposures which could significantly exceed chronic estimates...
September 19, 2017: Archives of Toxicology
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