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https://www.readbyqxmd.com/read/28642260/cigarette-smoke-disrupts-monolayer-integrity-by-altering-epithelial-cell-cell-adhesion-and-cortical-tension
#1
Kristine Nishida, Kieran A Brune, Nirupama Putcha, Pooja Mandke, Wanda K O'Neal, Danny Shade, Vasudha Srivastava, Menghen Wang, Hong Lam, Steven S An, M Bradley Drummond, Nadia N Hansel, Douglas N Robinson, Venkataramana K Sidhaye
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. Cigarette smoke (CS) drives disease development and progression. The epithelial barrier is damaged by CS with increased monolayer permeability. However, the molecular changes that cause this barrier disruption and the interaction between adhesion proteins and the cytoskeleton are not well defined. We hypothesized that CS alters monolayer integrity by increasing cell contractility and decreasing cell adhesion in epithelia...
June 22, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28641515/the-development-of-stem-cell-based-treatment-for-liver-failure
#2
Tiantian Zhu, Yuwen Li, Yusheng Guo, Chuanlong Zhu
Liver failure is a devastating clinical syndrome with a persistently mortality rate despite advanced care. According to the pathological histology, hepatic failure was divided into four categories: acute liver failure (ALF), subacute liver failure (SALF), acute - on - chronic liver failure (ACLF) and chronic liver failure (CLF). Orthotopic liver transplantation protected patients from hepatic failure. Yet, limitations including postoperative complications, high costs, and shortages of donor organs defect its application...
June 15, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28638013/-surgical-treatment-of-diabetic-neuroosteoarthropathy-dnoap-and-its-long-term-results
#3
V M Bensman, Yu P Savchenko, S E Gumenyuk, K G Triandafilov, P P Vasil'chenko, S N Pyatakov, V V Khoritonenko
AIM: To develop pathogenetically justified surgical treatment of diabetic neuroosteoarthropathy (DNOAP). MATERIAL AND METHODS: 52 patients were operated and long-term results were studied in 36 of them. 2 groups were assessed depending on completeness of surgical treatment including changed synovial structures removal. Tarso-metatarsal arthrodesis was created after synovectomy in median foot to restore longitudinal arch. Cruro-calcaneal neoarthrosis was performed after elimination of posterior focus of DNOAP...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28637113/case-report-of-intraventricular-schwannoma
#4
Adam A Razak, Gerry M O'Reilly, Robin Highley, Mohammed M Hussain
We describe the case of a 52 year old male presenting with subacute headache. Cranial imaging suggested haemorrhage into a parietal, partially intraventricular, space occupying lesion. The radiology was interpreted to be most consistent with a glioblastoma. The lesion was near totally resected. The histopathology was a WHO grade 1 schwannoma.
March 2, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28634315/-a-case-of-metastatic-brain-tumor-complicated-by-multiple-repeated-hemorrhages
#5
Kentaro Hayashi, Yukishige Hayashi, Yoshitaka Matsuo, Kiyoshi Shirakawa, Makio Kaminogo
Metastatic brain tumor occasionally results in multiple cerebral hemorrhages. Here, we report a case of metastatic brain tumor complicated by multiple repeated cerebral hemorrhages. An 80-year-old man with a history of removal of lung cancer was admitted to our hospital because of disturbed consciousness following headache. A brain CT revealed a mass lesion of 40-mm diameter in the left cerebellum and a mass lesion of 2-mm diameter in the right temporal lobe. The cerebellar mass lesion showed homogeneous iso-density, indicating a subacute phase hemorrhage...
June 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28631657/citrobacter-freundii-as-a-cause-of-acute-suppurative-thyroiditis-in-an-immunocompetent-adult-female
#6
Gursimran Kaur Mohi, Priya Datta, Jagdish Chander, Arjun Das
Acute suppurative thyroiditis (AST) is an uncommon condition, in the patients with preexisting thyroid disease or immunosuppression. The most common cause of AST is bacterial, and the most common bacteria are Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Klebsiella species. Due to various complications such as septicemia, septic thrombophlebitis, necrotizing mediastinitis, or pericarditis, prompt diagnosis and treatment are the keys to reduce mortality and morbidity. Here, we describe a case of a 40-year-old female with AST caused by Citrobacter freundii...
April 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28630851/vacuum-assisted-closure-in-patients-with-post-operative-infections-after-instrumented-spine-surgery-a-series-of-12-cases
#7
Maya Kale, Pravin Padalkar, Varshil Mehta
INTRODUCTION: Post-operative wound infections after spinal surgery is a very serious problem, leading to a risk of significant morbidity which may even lead to prolonged hospitalization. Various treatment protocols have been recommended for debridement, antibiotic, and soft-tissue management, but with mixed results. However, the risk of morbidity is still high with these treatment options. Vacuum-assisted closure (VAC) system has been gaining popularity recently in the management of subacute, acute, and chronic wounds...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28630846/chronic-recurrent-multifocal-osteomyelitis-a-case-report-with-atypical-presentation
#8
Miguel Pádua Figueiredo, Marco Pato, Fernando Amaral
INTRODUCTION: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory condition. The clinical picture consists of sterile osteomyelitis, typically with multiple-site lesions in the metaphysis of long bones and not uncommonly, symmetrical bone involvement. It is a poorly understood entity, whose prognosis, etiology and ideal treatment are still controversial. The authors report a case of unifocal presentation with an atypical location. CASE REPORT: A previously healthy 12-year-old Caucasian girl came to our institution due to progressive pain on her left thigh for the previous 3 months...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28630234/multiparametric-model-for-penumbral-flow-prediction-in-acute-stroke
#9
Michelle Livne, Tabea Kossen, Vince I Madai, Olivier Zaro-Weber, Walter Moeller-Hartmann, Kim Mouridsen, Wolf-Dieter Heiss, Jan Sobesky
BACKGROUND AND PURPOSE: Identification of salvageable penumbra tissue by dynamic susceptibility contrast magnetic resonance imaging is a valuable tool for acute stroke patient stratification for treatment. However, prior studies have not attempted to combine the different perfusion maps into a predictive model. In this study, we established a multiparametric perfusion imaging model and cross-validated it using positron emission tomography perfusion for detection of penumbral flow. METHODS: In a retrospective analysis of 17 subacute stroke patients with consecutive magnetic resonance imaging and H2O15 positron emission tomography scans, perfusion maps of cerebral blood flow, cerebral blood volume, mean transit time, time-to-maximum, and time-to-peak were constructed and combined using a generalized linear model (GLM)...
June 19, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28629340/hospital-readmission-within-10%C3%A2-years-post-stroke-frequency-type-and-timing
#10
Gitta Rohweder, Øyvind Salvesen, Hanne Ellekjær, Bent Indredavik
BACKGROUND: The aim of this study was to examine the hospital readmissions in a 10 year follow-up of a stroke cohort previously studied for acute and subacute complications and to focus on their frequency, their causes and their timing. METHODS: The hospital records of 243 patients, 50% of a cohort of 489 patients acutely and consecutively admitted to our stroke unit in 2002/3, were subjected to review 10 years after the incidental stroke and all acute admissions were examined...
June 19, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28628600/alterations-in-brain-derived-neurotrophic-factor-and-insulin-like-growth-factor-1-protein-levels-after-penetrating-ballistic-like-brain-injury-in-rats
#11
Sindhu K Madathil, Ying Deng-Bryant, Bernard S Wilfred, Lai Yee Leung, Janice S Gilsdorf, Deborah A Shear
BACKGROUND: Brain-derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1) are essential for neuroplasticity and neuronal survival. Despite the importance of these endogenous factors in mediating posttraumatic recovery, little is known about their response after penetrating type traumatic brain injury. The objective of this study was to quantify the expression levels BDNF and IGF-1, two well-known neuroplasticity mediators, after penetrating ballistic-like brain injury (PBBI)...
July 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28627959/two-cases-of-primary-leptomeningeal-melanomatosis-mimicking-subacute-meningitis
#12
Sabina Aslan, Rahsan Gocmen, Nazire Pınar Acar, Farid Khasiyev, Ekim Gumeler, Figen Soylemezoglu, Aslı Tuncer, Ethem Murat Arsava, Mehmet Akif Topçuoglu, Isin Unal Cevik
Primary involvement of leptomeninges with melanocytic tumours is rarely seen and its diagnosis is challenging. Here we summarise two cases of primary leptomeningeal melanomatosis presenting as subacute meningitis. Both cases have pleocytosis and high protein on cerebrospinal fluid analysis, and demonstrated atypical cells on cytology. On magnetic resonance imaging, there is diffuse leptomeningal thickening and avid enhancement of intracranial and intraspinal leptomeninges. One of them demonstrates T1 shortening due to magnetic effects of melanin, the other case is amelanotic and shows hypointensity on precontrast T1-weighted images...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28626337/is-robot-assisted-therapy-effective-in-upper-extremity-recovery-in-early-stage-stroke-a-systematic-literature-review
#13
REVIEW
GaYeong Kim, SeungYeop Lim, HyunJong Kim, ByungJoon Lee, SeungChul Seo, KiHun Cho, WanHee Lee
[Purpose] The aim of this study was to systematically investigate the effects of robot-assisted therapy on the upper extremity in acute and subacute stroke patients. [Subjects and Methods] The papers retrieved were evaluated based on the following inclusion criteria: 1) design: randomized controlled trials; 2) population: stroke patients 3) intervention: robot-assisted therapy; and 4) year of publication: May 2012 to April 2016. Databased searched were: EMBASE, PubMed and COCHRAN databases. The Physiotherapy Evidence Database (PEDro) scale was used to assess the methodological quality of the included studies...
June 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28626306/effects-of-task-oriented-circuit-training-on-balance-and-gait-ability-in-subacute-stroke-patients-a-randomized-controlled-trial
#14
Kyoung Kim, Sang In Jung, Dong Kyu Lee
[Purpose] The aim of this study was to investigate the effects of the task-oriented circuit training on balance and gait ability in subacute patients with stroke. [Subjects and Methods] Participants were randomly allocated to two groups: group 1 (subjects who performed task-oriented circuit training) and group 2 (subjects who underwent conventional physical therapy). Berg balance scale, timed up and go test, functional ambulation category, 6-minute walk test were assessed before and after four weeks of training...
June 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28626050/admission-brain-cortical-volume-an-independent-determinant-of-poststroke-cognitive-vulnerability
#15
Sharmila Sagnier, Gwenaëlle Catheline, Bixente Dilharreguy, Fanny Munsch, Antoine Bigourdan, Mathilde Poli, Sabrina Debruxelles, Stéphane Olindo, Pauline Renou, François Rouanet, Vincent Dousset, Thomas Tourdias, Igor Sibon
BACKGROUND AND PURPOSE: Several markers of poststroke cognitive impairment have been reported. The role of brain cortical volume remains uncertain. The aim of this study was to evaluate the influence of brain cortical volume on cognitive outcomes using a voxel-based morphometry approach in subjects without prestroke dementia. METHODS: Ischemic stroke patients were prospectively recruited 24 to 72 hours post-stroke (M0). Cognition was evaluated at M0, 3 months, and 1 year (M12) using the Montreal Cognitive Assessment, the Isaacs set test, and the Zazzo's cancellation task...
June 16, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28620416/antiphospholipid-syndrome-multiple-manifestations-in-a-single-patient-a-high-suspicion-is-still-needed
#16
Uroosa Ibrahim, Shiksha Kedia, Gwenalyn Garcia, Jean Paul Atallah
Antiphospholipid Syndrome (APS) is an autoimmune disorder with clinical and laboratory features of vascular thrombosis, pregnancy loss, and persistent antiphospholipid antibodies (aPLs). The pathophysiology is thought to involve the activation of endothelial cells, monocytes, platelets, and complement by aPLs. Disease can range from asymptomatic to rapidly fatal catastrophic APS. We present a case of a 34-year-old male referred for pancytopenia and splenomegaly. On examination, he had decreased sensation and 4/5 power in the left upper extremity...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28619087/longitudinal-estimation-of-intramuscular-tibialis-anterior-coherence-during-subacute-spinal-cord-injury-relationship-with-neurophysiological-functional-and-clinical-outcome-measures
#17
Elisabeth Bravo-Esteban, Julian Taylor, Manuel Aleixandre, Cristina Simón-Martínez, Diego Torricelli, Jose Luis Pons, Gerardo Avila-Martín, Iriana Galán-Arriero, Julio Gómez-Soriano
BACKGROUND: Estimation of surface intramuscular coherence has been used to indirectly assess pyramidal tract activity following spinal cord injury (SCI), especially within the 15-30 Hz bandwidth. However, change in higher frequency (>40 Hz) muscle coherence during SCI has not been characterised. Thus, the objective of this study was to identify change of high and low frequency intramuscular Tibialis Anterior (TA) coherence during incomplete subacute SCI. METHODS: Fifteen healthy subjects and 22 subjects with motor incomplete SCI (American Spinal Injury Association Impairment Scale, AIS, C or D grade) were recruited and tested during 4 sessions performed at 2-week intervals up to 8 months after SCI...
June 15, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28617265/a-case-of-fulminant-subacute-sclerosing-panencephalitis-presenting-with-acute-myoclonic-astatic-epilepsy
#18
Fabio Magurano, Gian Luca Marella, Antonella Marchi, Antonietta Filia, Luigi Tonino Marsella, Saverio Potenza, Roberto Massa, Paola Bucci, Melissa Baggieri, Loredana Nicoletti
The neurologic sequelae post-measles are less common than other complications measles-related and can lead to severe disability or death: primary measles encephalitis (PME), acute post-infectious measles encephalomyelitis (APME), measles inclusion body encephalitis (MIBE), and subacute sclerosing panencephalitis (SSPE). SSPE syndrome can affect people years from the acute measles virus infection, as result of the persistence of defective viral particles in brain cells. Clinical onset typically manifests with progressive intellectual deterioration, behavioral changes, and myoclonic jerks...
April 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28616358/parkinsonism-and-tremor-in-a-patient-with-plasmodium-vivax-malaria
#19
Jung E Park
BACKGROUND: A 57-year-old male diagnosed with Plasmodium vivax malaria presented with a subacute onset of hand tremor, slowness, and gait difficulty. PHENOMENOLOGY: A bilateral upper extremity kinetic tremor was seen, as well as a right upper extremity rigidity and body bradykinesia. EDUCATIONAL VALUE: Parkinsonism and tremor are neurological manifestations that may occur in malaria as a result of globus pallidi and dentate nuclei involvement...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28615616/early-stage-mucinous-ovarian-adenocarcinoma-with-extensive-clotting-in-a-previously-healthy-young-female-patient-an-uncommon-presentation-of-a-relatively-uncommon-disease
#20
Suchin R Khanna, Brave Nguyen, Mahmoud Charif
BACKGROUND Mucinous ovarian adenocarcinoma is one of the less common epithelial cancers of the ovaries, and typically does not occur in younger women. Nearly all mucinous ovarian adenocarcinomas present with early-stage disease without significant sequelae of cancer, such as clotting. Anchoring bias is a common problem in medicine that has been shown to significantly affect physician decision-making. CASE REPORT We present the case of a 24-year-old healthy female Chinese immigrant with no significant past medical history, who presented with a subacute history of nonproductive cough and shortness of breath with exertion...
June 15, 2017: American Journal of Case Reports
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