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https://www.readbyqxmd.com/read/28440910/subacute-pyridostigmine-exposure-increases-heart-rate-recovery-and-cardiac-parasympathetic-tone-in-rats
#1
Manushree Bharadwaj, Carey Pope, Michael Davis, Stuart Katz, Christian Cook, Lara Maxwell
Heart rate recovery (HRR) describes the rapid deceleration of heart rate after strenuous exercise and is an indicator of parasympathetic tone. A reduction in parasympathetic tone occurs in patients with congestive heart failure, resulting in prolonged HRR. Acetylcholinesterase inhibitors, such as pyridostigmine, can enhance parasympathetic tone by increasing cholinergic input to the heart. The objective of this study was to develop a rodent model of HRR to test the hypothesis that subacute pyridostigmine administration decreases cholinesterase activity and accelerates HRR in rats...
April 25, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28440586/comparison-of-preoperative-quantitative-magnetic-resonance-imaging-and-clinical-assessment-of-deep-pain-perception-as-prognostic-tools-for-early-recovery-of-motor-function-in-paraplegic-dogs-with-intervertebral-disk-herniations
#2
A Wang-Leandro, J S Siedenburg, M K Hobert, P Dziallas, K Rohn, V M Stein, A Tipold
BACKGROUND: Prognostic tools to predict early postoperative motor function recovery (MFR) after thoracolumbar intervertebral disk herniation (IVDH) in paraplegic dogs represent an opportunity to timely implement novel therapies that could shorten recovery times and diminish permanent neurological dysfunctions. HYPOTHESIS: Fractional anisotropy (FA) values obtained using diffusion tensor imaging have a higher prognostic value than a lesion extension ratio in T2-weighted images (T2W-LER) and clinical assessment of deep pain perception (DPP) for MFR...
April 25, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28439734/myocardial-salvage-after-primary-percutaneous-coronary-intervention-in-patients-with-st-elevation-myocardial-infarction-presenting-early-versus-late-after-symptom-onset
#3
Thomas Stiermaier, Ingo Eitel, Suzanne de Waha, Janine Pöss, Georg Fuernau, Holger Thiele, Steffen Desch
Primary percutaneous coronary intervention (PCI) is the treatment of choice in patients with ST-elevation myocardial infarction (STEMI) presenting within 12 h of symptom onset. A benefit in the subacute stage is less clear. The aim of the present analysis was to compare myocardial salvage and infarct size between patients with early and late reperfusion after STEMI. We compared cardiac magnetic resonance (CMR) data from a randomized controlled trial (RCT) in STEMI patients presenting within 12 h (n = 695) and a RCT of subacute STEMI patients presenting between 12 and 48 h (n = 93) after symptom onset...
April 24, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28438848/clinical-reasoning-a-71-year-old-woman-with-subacute-progressive-distal-weakness-and-paresthesia-after-vaccination
#4
Simão Cruz, Andrew M Schaefer, Abhijit Joshi, Mark R Baker
No abstract text is available yet for this article.
April 25, 2017: Neurology
https://www.readbyqxmd.com/read/28432042/syndrome-of-inappropriate-antidiuretic-hormone-accompanied-by-bilateral-hypothalamic-and-anterior-thalamic-lesions-with-serum-antiaquaporin-4-antibody
#5
Kosuke Inoue, Takahiro Nakayama, Aya Kamisawa, Jun Saito
We described a rare case of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and severe unconsciousness accompanied by bilateral hypothalamic and anterior thalamic lesions with positive serum antiaquaporin 4 (AQP4) antibody. A 29-year-old man was admitted to our hospital due to the subacute progression of an unconscious state. He was observed to be hyponatraemic secondary to SIADH. Brain MRI showed bilateral hypothalamic and anterior thalamic lesions. Anti-AQP4 antibody was detected in his serum...
April 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28432017/dual-functional-nanoparticles-for-precise-drug-delivery-to-alzheimer-s-disease-lesions-targeting-mechanisms-pharmacodynamics-and-safety
#6
Xiaoyao Zheng, Chi Zhang, Qian Guo, Xu Wan, Xiayan Shao, Qingfeng Liu, Qizhi Zhang
Alzheimer's disease (AD) is the most common form of dementia and is characterized by the cerebral accumulation of extracellular amyloid plaques. In a previous study, this histopathological hallmark was used as a target on a dual-functional nanoparticle (TQNP) to deliver biotechnological drugs, such as the H102 peptide, a β-sheet breaker, to AD lesions precisely. This delivery system could reduce the amyloid-β (Aβ) burden in the brains of AD model mice, as well as ameliorated the memory impairment of the mice...
April 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28431710/subacute-pericardial-tamponade-after-sleeve-lower-lobectomy-for-an-extremely-rare-tumor
#7
Michael G Astudillo, Andrew P Dhanasopon, Anthony W Kim
A rare case of subacute cardiac tamponade developed in a 71-year-old patient after a left lower lobe sleeve lobectomy for cancer. The patient was successfully treated by drainage of the pericardial effusion by a pigtail catheter. The exact cause is uncertain, but it appears to include an inflammatory component.
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28429255/acute-subacute-neuro-behcet-s-disease
#8
Marinos Kontzialis, Melike Guryildirim
No abstract text is available yet for this article.
April 20, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28428526/-strategy-of-thoracic-endovascular-aortic-repair-for-uncomplicated-type-b-aortic-dissection-in-subacute-and-chronic-phase-interval-from-onset-and-maximum-diameter
#9
Masatoshi Sunada, Kyohei Ueno, Rie Kageyama, Satoru Maeba, Hirofumi Midorikawa, Megumu Kanno
We classified 59 patients who underwent thoracic endovascular aortic repair for uncomplicated type B aortic dissection from April 2008 to April 2016 into 3 groups based on time from onset and maximum aortic diameter:SA (2weeks to 1 year since onset;n=29), C (>1 year since onset;n=17), and D(maximum aneurysm size≥60 mm;n=13). We used the Kaplan-Meier method tso analyze survival, major adverse cardiovascular event and the need for additional treatment. There was no significant difference in outcomes between the SA and C groups (p=0...
April 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28427702/long-term-clinical-and-radiologic-follow-up-of-schilder-s-disease
#10
Hülya Maraş Genç, Bülent Kara, Emek Uyur Yalçın, Ayfer Sakarya Güneş, Adnan Deniz, Yonca Anık
BACKGROUND: Schilder's disease is a rare, subacute, or chronic demyelinating disorder that mainly affects children and generally shows a monophasic course. CASE: Here, we present three boys diagnosed with Schilder's disease, age at onset 10-14 years, and followed up for 4-8 years. All of them presented with headache, two with encephalopathy and vomiting, and one with diplopia and vertigo. Cranial magnetic resonance imaging (MRI) showed two large demyelinating lesions, asymmetric in two patients and symmetric in the other...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28424927/development-of-new-extra-glandular-manifestations-or-associated-auto-immune-diseases-after-establishing-the-diagnosis-of-primary-sj%C3%A3-gren-s-syndrome-a-long-term-study-of-the-antonius-nieuwegein-sj%C3%A3-gren-ans-cohort
#11
E J Ter Borg, J C Kelder
To investigate in a long-term study, the development of new extra-glandular manifestations (EGM) or associated auto-immune diseases (AID) from 1 year after establishing the diagnosis of primary Sjögren's syndrome (pSS). The primary goal was to examine the frequency and type of these manifestations and to find out which demographic, clinical and serological profile was most at risk. All outpatients diagnosed with primary Sjögren's syndrome were included in a retrospective study, with at least one check-up per year, from June 1991 until August 2015...
April 19, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28424456/paraquat-poisoning-induced-pulmonary-epithelial-mesenchymal-transition-through-notch1-pathway
#12
Tiegang Li, Xiangming Yang, Shiyu Xin, Yan Cao, Nana Wang
Progressive pulmonary fibrosis is the most characteristic feature of subacute PQ poisoning. Epithelial-to-mesenchymal transition (EMT) is reported to be involved in the pulmonary fibrosis after PQ exposure. Recent evidence suggested Notch signaling is required for EMT. In this study, we investigated whether Notch1 and TGF-β1/Smad3 signaling was involved in EMT caused by PQ. It is demonstrated that A549 cells underwent EMT after treated with PQ at dose of 300 μmol/L for 6 days, charactered by increasing expression of mesenchymal marker α-SMA and decreasing expression of epithelial marker E-cadherin...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28423386/early-longitudinal-spectral-domain-optical-coherence-tomography-findings-in-subacute-sclerosing-panencephalitis
#13
João Beato, Manuel S Falcão, Henrique Costa, Luís Figueira, Renato Santos-Silva, Susana Penas, Elisete Brandão, Ângela Carneiro, Fernando Falcão-Reis
No abstract text is available yet for this article.
May 2017: Retina
https://www.readbyqxmd.com/read/28416071/-acute-upper-airway-obstruction-caused-by-a-multinodular-goitre-after-tracheotomy
#14
Chadi Nimeh Abdel-Halim, Bibi Lange
This case report illustrates how a multinodular goitre caused acute airway obstruction in a multitrauma 66-year-old male after tracheotomy. The patient had no symptoms of the goitre before the tracheotomy but developed subglottic airway obstruction at the time of decannulation. He underwent a subacute total thyroidectomy which removed the obstructive symptoms. A weakening of the tracheal tube followed by the tracheotomy possibly caused the tracheal stenosis in combination with the goitre.
April 3, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28413671/paraneoplastic-limbic-encephalitis-in-a-patient-with-extensive-disease-small-cell-lung-cancer
#15
Sebastian Ochenduszko, Bartosz Wilk, Joanna Dabrowska, Izabela Herman-Sucharska, Anna Dubis, Miroslawa Puskulluoglu
Paraneoplastic limbic encephalitis (PLE) is a rare disorder infrequently accompanying malignancy, coexisting in ~50% of the cases with small-cell lung cancer (SCLC). The pathomechanism of PLE is considered to be immune-mediated, with production of specific anti-Hu antibodies and activation of T-cells directed against onconeural antigens present on both tumor cells and neurons. We herein report the case of a 50-year-old male patient who, prior to being diagnosed with SCLC, presented with typical symptoms of PLE (seizures, subacute cognitive dysfunction with severe memory impairment, anxiety and hallucinations)...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28413058/erythromelalgia-identification-of-a-corticosteroid-responsive-subset
#16
Gabriel L Pagani-Estévez, Paola Sandroni, Mark D Davis, James C Watson
BACKGROUND: Corticosteroids (CS) may benefit certain patients with erythromelalgia. OBJECTIVES: Our objective was to determine clinical predictors of corticosteroid-responsive erythromelalgia. METHODS: Patients with erythromelalgia who received CS were identified and stratified into corticosteroid nonresponders (NRs), partial corticosteroid responders (PSRs), complete corticosteroid responders (CSRs), and steroid responders (SRs = PSRs + CSRs)...
March 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28412986/effects-of-subacute-ingestion-of-chlorogenic-acids-on-sleep-architecture-and-energy-metabolism-through-activity-of-the-autonomic-nervous-system-a-randomised-placebo-controlled-double-blinded-cross-over-trial
#17
Insung Park, Ryuji Ochiai, Hitomi Ogata, Momoko Kayaba, Sayaka Hari, Masanobu Hibi, Yoshihisa Katsuragi, Makoto Satoh, Kumpei Tokuyama
Chlorogenic acids (CGA) are the most abundant polyphenols in coffee. Continuous consumption of CGA reduces body fat and body weight. Since energy metabolism and sleep are controlled by common regulatory factors, consumption of CGA might modulate sleep. Lack of sleep has been identified as a risk factor for obesity, hypertension and type 2 diabetes. The aim of this study was to determine the effects of ingesting CGA over 5 d on energy metabolism and sleep quality in humans. A total of nine healthy subjects (four male and five female) completed a placebo-controlled, double-blinded, cross-over intervention study...
April 17, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28409015/use-of-slicc-criteria-in-a-large-diverse-lupus-registry-enables-sle-classification-of-a-subset-of-acr-designated-subjects-with-incomplete-lupus
#18
Teresa Aberle, Rebecka L Bourn, Hua Chen, Virginia C Roberts, Joel M Guthridge, Krista Bean, Julie M Robertson, Kathy L Sivils, Astrid Rasmussen, Meghan Liles, Joan T Merrill, John B Harley, Nancy J Olsen, David R Karp, Judith A James
OBJECTIVE: SLE is traditionally classified using the American College of Rheumatology (ACR) criteria. The Systemic Lupus International Collaborating Clinics (SLICC) recently validated an alternative system. This study examined large cohorts of subjects with SLE and incomplete lupus erythematosus (ILE) to compare the impact of ACR and SLICC criteria. METHODS: Medical records of subjects in the Lupus Family Registry and Repository were reviewed for documentation of 1997 ACR classification criteria, SLICC classification criteria and medication usage...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/28406071/validation-and-reliability-of-the-spanish-version-of-the-function-in-sitting-test-s-fist-to-assess-sitting-balance-in-subacute-post-stroke-adult-patients
#19
Rosa Cabanas-Valdés, Caritat Bagur-Calafat, Fernanda Maria Caballero-Gómez, Carmen Cervera-Cuenca, Raúl Moya-Valdés, Pere Ramón Rodríguez-Rubio, Gerard Urrútia
BACKGROUND: Function in Sitting Test (FIST) is a clinical functional assessment of sitting balance validated in adults with stroke. For a major use of this, the test is recommended to be translated in Spanish-speaking countries. OBJECTIVES: Translate to Spanish the FIST and determine its intra-rater and inter-rater reliabilities and concurrent validity as a measure of sitting balance in adult individuals with stroke. METHODS: The original version was translated into Spanish and was agreed by a team of experts...
April 13, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28404683/brain-eating-amoebae-predilection-sites-in-the-brain-and-disease-outcome
#20
Timothy Yu Yee Ong, Naveed Ahmed Khan, Ruqaiyyah Siddiqui
Acanthamoeba spp. and Balamuthia mandrillaris are causative agents of granulomatous amoebic encephalitis (GAE), while Naegleria fowleri causes primary amoebic meningoencephalitis (PAM). PAM is an acute infection lasting few days, while GAE is a chronic to subacute infection that can last up to several months. Here, we present a literature review of 86 case reports from 1968 to 2016 in order to explore affinity of these amoebae towards particular sites of the brain, diagnostic modalities, treatment options and the disease outcome in a comparative manner...
April 12, 2017: Journal of Clinical Microbiology
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