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Oral epidermoid carcinoma

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https://www.readbyqxmd.com/read/29427328/depletion-of-keratin-8-18-modulate-oncogenic-potential-by-governing-multiple-signaling-pathways
#1
Richa Tiwari, Indrajit Sahu, Bihari Lal Soni, Gajanan J Sathe, Pankaj Thapa, Pavan Patel, Shruti Sinha, Chella Krishna Vadivel, Shweta Patel, Sayli Nitin Jamghare, Swapnil Oak, Rahul Thorat, Harsha Gowda, Milind M Vaidya
Keratin 8/18 the predominant keratin pair of simple epithelia is often aberrantly expressed in various squamous cell carcinomas (SCCs) including skin-SCC. Its aberrant expression is correlated with increased invasiveness and poor prognosis of the same, although the underlying mechanism is still unclear. A previous report from our laboratory has shown K8 mediated regulation of α6β4 integrin signaling and thereby tumorigenic potential of oral-SCC derived cells. Another study on transgenic mouse model has shown that during skin carcinogenesis, K8 favors conversion of papillomas towards malignancy...
February 10, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29274149/evolution-of-oral-neoplasm-in-an-andalusian-population-spain
#2
R Flores-Ruiz, L Castellanos-Cosano, M-A Serrera-Figallo, A Gutiérrez-Corrales, R Castillo-Oyague, J-L Gutiérrez-Perez, D Torres-Lagares
BACKGROUND: Head and neck cancer are one of the most common neoplasm pathologies in humans. The aim of this study was to analyze the type, characteristics, treatment and evolution of oral neoplasm or precancerous lesion in a sample of Andalusian population (Spain) derived from the Oncology Rehabilitation Hospital Unit during a period of 20 years. MATERIAL AND METHODS: A retrospective descriptive study was carried out during the years 1991 and 2011 analyzing the type, characteristics, treatment and follow-up of oral neoplasm in the Oral and Maxillofacial Surgery Unit of the Universitary Hospital Virgen del Rocio...
January 1, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29074436/dhpac-a-novel-synthetic-microtubule-destabilizing-agent-possess-high-anti-tumor-activity-in-vincristine-resistant-oral-epidermoid-carcinoma-in-vitro-and-in-vivo
#3
Ying Zhang, Fu-Lian Gong, Zhen-Ning Lu, Hong-Yuan Wang, Yan-Na Cheng, Zhao-Peng Liu, Lu-Gang Yu, Hui-Hui Zhang, Xiu-Li Guo
Multidrug resistance (MDR) is one of major obstacles to effective chemotherapeutic treatment of cancer. This study showed that DHPAC, 2-(6-ethoxy-3-(3-ethoxyphenylamino) -1-methyl-1,4-dihydroindeno[1,2-c]pyrazol-7-yloxy) acetamide, a novel compound that binds to the same site on microtubules as colchicine, has high anti-tumour activity in vincristine-resistant oral epidermoid carcinoma (KB/V) cells. It found that the presence of DHPAC strongly inhibited KB/V cell growth in vivo and in mice xenograft. The inhibitory effect of DHPAC is much stronger than that by colchicine in these KB/V cells (IC50: 64...
October 23, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28953734/the-horizontal-myocutaneous-infrahyoid-island-flap-for-soft-tissue-head-and-oral-reconstruction-step-by-step-video-description
#4
Charlie Verbruggen, Claire Majoufre, Laure Derosamel, Pierre-Antoine Dubreuil, Gabrielle Vallade, Caroline Mage, Quentin Sessiecq, Mathieu Bondaz
A clinical case is presented of a 70-year-old woman suffering from a right hemilingual epidermoid carcinoma. A step-by-step video description of the regional infrahyoid island flap is presented and narrated. Long-term results at 2 months in terms of aesthetics and function at the recipient and donor sites are excellent. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, V.
October 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28864403/clinical-outcomes-of-several-imrt-techniques-for-patients-with-head-and-neck-cancer-a-propensity-score-weighted-analysis
#5
MULTICENTER STUDY
Jean-Emmanuel Bibault, Sophie Dussart, Pascal Pommier, Magali Morelle, Marius Huguet, Pierre Boisselier, Bernard Coche-Dequeant, Marc Alfonsi, Etienne Bardet, Michel Rives, Valentin Calugaru, Enrique Chajon, Georges Noel, Hinda Mecellem, Stephanie Servagi Vernat, Lionel Perrier, Philippe Giraud
PURPOSE: The Advanced Radiotherapy Oto-Rhino-Laryngologie (ART-ORL) study (NCT02024035) was performed to prospectively evaluate the clinical and economic aspects of helical TomoTherapy and volumetric modulated arc therapy (RapidArc, Varian Medical Systems, Palo Alto, CA) for patients with head and neck cancer. METHODS AND MATERIALS: Fourteen centers participated in this prospective comparative study. Randomization was not possible based on the availability of equipment...
November 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28710602/eldecalcitol-ed-71-an-analog-of-1%C3%AE-25-oh-2d3-inhibits-the-growth-of-squamous-cell-carcinoma-scc-cells-in-vitro-and-in-vivo-by-down-regulating-expression-of-heparin-binding-protein-17-fibroblast-growth-factor-binding-protein-1-hbp17-fgfbp-1-and-fgf-2
#6
T Shintani, F Takatsu, S N Z Rosli, E Usui, A Hamada, K Sumi, Y Hayashido, S Toratani, Tetsuji Okamoto
Heparin-binding protein 17 (HBp17)/fibroblast growth factor-binding protein-1 (FGFBP-1) was first purified from medium conditioned by A431 cells for its capacity to bind to fibroblast growth factors 1 and 2 (FGF-1 and -2). Among FGF family members, FGF-2 is a potent mitogen for various cell types, including vascular endothelial cells, fibroblasts, and cancer cells such as oral squamous cell carcinoma (OSCC) cells. Besides being well known in bone metabolism, the active form of vitamin D3, i.e., 1α,25(OH)2D3 (1,25D3), was reported to have protective effects for heart disease and cancer...
October 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28455420/widespread-use-of-misidentified-cell-line-kb-hela-incorrect-attribution-and-its-impact-revealed-through-mining-the-scientific-literature
#7
Liwen Vaughan, Wolfgang Glänzel, Christopher Korch, Amanda Capes-Davis
Continuous cell lines are widely used, but can result in invalid, irreproducible research data. Cell line misidentification is a common problem that can be detected by authentication testing; however, misidentified cell lines continue to be used in publications. Here we explore the impact of one misidentified cell line, KB (HeLa), on the scientific literature. We identified 574 articles between 2000 and 2014 that provided an incorrect attribution for KB, in accordance with its false identity as oral epidermoid carcinoma, but only 57 articles that provided a correct attribution for KB, as HeLa or cervical adenocarcinoma...
June 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28301021/cytotoxic-effect-of-thymus-caramanicus-jalas-on-human-oral-epidermoid-carcinoma-kb-cells
#8
Reza Fekrazad, Mehrad Afzali, Hamzeh Pasban-Aliabadi, Saeed Esmaeili-Mahani, Maryam Aminizadeh, Ali Mostafavi
Identifying new chemotherapeutic agents with fewer side effects is a major concern for scientists today. Thymus caramanicus Jalas (Lamiaceae family) is one of the species of Thymus that grows wild in different regions of Iran. Traditionally, leaves of this plant are used in the treatment of diabetes, arthritis and cancer. Here was investigated the cytotoxic property of Thymus caramanicus essential oil and extract in human oral epidermoid carcinoma KB cells. Cell viability was measured by MTT and neutral red assays...
January 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/28008808/antitumor-activity-of-extracts-from-medicinal-basidiomycetes-mushrooms
#9
Elena Vetchinkina, Alexandr Shirokov, Alla Bucharskaya, Nikita Navolokin, Artur Prilepskii, Andrey Burov, Galina Maslyakova, Valentina E Nikitina
Aqueous extracts from the vegetative submerged mycelia of cultivated Basidiomycetes Ganoderma lucidum, Lentinus edodes, and Grifola frondosa, as well as from the fruiting bodies of G. lucidum, were found to have antitumor activity. The antitumor effect of the mycelial extracts from all 3 fungal species was ascertained in vivo in rats with implanted kidney cancer. Dystrophic changes in tumor cells and tumor necrosis (up to 90%) were noted. In vitro cytotoxicity studies of the A549 human lung adenocarcinoma cell line and HEp-2 human laryngeal epidermoid carcinoma cells showed that the extracts from the G...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27920642/recurrent-complete-pharyngo-oesophageal-stricture-treated-by-multidisciplinary-anterograde-retrograde-endoscopic-dilation
#10
Paulo Castro Soares, Salim Bouayed, Pavel Dulguerov, Jean-Louis Frossard
Complete pharyngo-oesophageal stricture (PES) after radiotherapy for head and neck cancer is a relatively rare and difficult complication to manage. Historically this condition has been treated surgically, but endoscopic approaches are now available. We present a 61-year-old man with an epidermoid carcinoma of the supraglottic stage and a micro-invasive epidermoid carcinoma of the oropharynx treated surgically and subsequently by adjuvant radiotherapy. Eight months after the end of the radiotherapy, a complete PES was diagnosed and treated with a combined anterograde-retrograde endoscopic dilation (CARD)...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27791423/an-unusual-complication-of-nasolabial-flap-reconstruction
#11
R Mann, B Srinivasan, R Webb, A Webb
Squamous cell carcinoma is the most common carcinoma in the oral cavity. Resection of these cancers often requires reconstruction. Nasolabial flaps are a robust and reliable local flap that provide a satisfactory outcome. We report two cases where an epidermoid cyst developed within the scar of the nasolabial flap and review the literature.
February 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27780132/the-scorpion-venom-peptide-bmkn2-induces-apoptosis-in-cancerous-but-not-in-normal-human-oral-cells
#12
Saranya Satitmanwiwat, Chinarat Changsangfa, Anuson Khanuengthong, Kornkanok Promthep, Sittiruk Roytrakul, Teerakul Arpornsuwan, Kulnasan Saikhun, Hathaitip Sritanaudomchai
AIM: This study aimed to investigate the mechanism of the induction of apoptosis of human oral cancer cells by the scorpion venom peptide BmKn2. METHODS: Human oral squamous carcinoma cells (HSC4), mouth epidermoid carcinoma cells (KB), human normal gingival cells (HGC) and dental pulp cells (DPC) were treated with BmKn-2 peptide for 24h. Cell viability was determined by the MTT assay. Apoptosis was assessed using phase contrast microscopy, by propidium iodide (PI) staining to assess nuclear morphology and by Annexin V staining...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27769871/reevaluation-of-maml2-fusion-negative-mucoepidermoid-carcinoma-a-subgroup-being-actually-hyalinizing-clear-cell-carcinoma-of-the-salivary-gland-with-ewsr1-translocation
#13
Min-Shu Hsieh, Hsuang Wang, Yi-Hsuan Lee, Jenq-Yuh Ko, Yih-Leong Chang
Hyalinizing clear cell carcinoma (HCCC) is a rare salivary gland tumor with a specific EWSR1-ATF1 fusion gene and can have mucin production. Mucoepidermoid carcinoma (MEC) with a clear cell component is its morphologic mimic. Using MAML2 fluorescence in situ hybridization (FISH), a total of 49 MEC cases were separated into MAML2 fusion-positive (32 cases) and MAML2 fusion-negative groups (17 cases). This study used EWSR1 FISH to investigate MAML2 fusion-negative cases to identify previously unrecognized HCCC...
March 2017: Human Pathology
https://www.readbyqxmd.com/read/27730326/radiotherapy-for-elderly-patients-and-cetuximab-a-monocentric-study
#14
Alexander T Falk, Christophe Hébert, Antoine Tran, Marie-Eve Chand, Axel Leysalle, Juliette Thariat, Olivier Dassonville, Gilles Poissonnet, Alexandre Bozec, Esma Saada, Fréderic Peyrade, Karen Benezery
Concomitant radiotherapy and cetuximab association has shown superiority to exclusive radiotherapy for head and neck cancers. Data on this association are scarce for the elderly population despite its rising incidence. A retrospective monocentric data collection was performed in the Antoine Lacassagne Cancer Center in France. Inclusion criteria were: age >70 years at time of diagnosis, histologically proven head and neck epidermoid carcinoma, treated with radiotherapy combined with cetuximab. Thirty-five patients were included between 2008 and 2012...
February 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27649452/synthesis-biological-screening-and-molecular-docking-studies-of-some-tin-iv-schiff-base-adducts
#15
Wajid Rehman, Rehana Yasmeen, Fazal Rahim, Muhammad Waseem, Cun-Yue Guo, Zonera Hassan, Umer Rashid, Khurshid Ayub
The search for an alternative to platinum anticancer agents is a major motivation for continuing investigations concerning the antitumor properties of other transition metal-based compounds. Keeping this in view, synthesis, antitumor and antimicrobial activity of diorganotin (IV) complexes was studied. A novel series of diorganotin (IV) complexes of the Schiff base ligand derived from 7-methoxy-2-hydroxy-1-naphthaldehyde, 1,2-phenylenediamine, Salicylaldehyde were synthesized. Physical and spectral examination was done through various techniques using elemental analyses, IR, (1)H, (13)C, (119)Sn NMR, and (119m)Sn Mössbauer techniques respectively...
November 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27416556/rosiglitazone-elevates-sensitization-of-drug-resistant-oral-epidermoid-carcinoma-cells-to-vincristine-by-g2-m-phase-arrest-independent-of-ppar-%C3%AE-pathway
#16
Hong-Yuan Wang, Ying Zhang, Yue Zhou, Yu-Yin Lu, Wen-Fang Wang, Ming Xin, Xiu-Li Guo
Rosiglitazone (ROSI), an oral antidiabetic agent, has been reported the anti-cancer properties recent years. In this paper, the potency of ROSI as a synergistic drug for vincristine (VCR) on resistant oral cancer cells was investigated. We found that ROSI potently enhanced the susceptibility of KB cells or KB/V cells to VCR in a dose manner and the synergy in KB/V cells was much more prominent than that in KB cells. The synergistic anti-proliferative effect of ROSI and VCR was associated with inhibition on tubulin polymerization, cell cycle arrest in G2/M phase and cell apoptosis induction, but has no effect on drug efflux-protein P-gp and was independent with PPARγ...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27345843/toxicity-and-efficacy-of-cetuximab-associated-with-several-modalities-of-imrt-for-locally-advanced-head-and-neck-cancer
#17
MULTICENTER STUDY
J-E Bibault, M Morelle, L Perrier, P Pommier, P Boisselier, B Coche-Dequéant, O Gallocher, M Alfonsi, É Bardet, M Rives, V Calugaru, E Chajon, G Noël, H Mecellem, D Pérol, S Dussart, P Giraud
PURPOSE: Intensity-modulated radiation therapy (IMRT) has shown its interest for head and neck cancer treatment. In parallel, cetuximab has demonstrated its superiority against exclusive radiotherapy. The objective of this study was to assess the acute toxicity, local control and overall survival of cetuximab associated with different IMRT modalities compared to platinum-based chemotherapy and IMRT in the ARTORL study (NCT02024035). PATIENTS AND METHOD: This prospective, multicenter study included patients with epidermoid or undifferentiated nasopharyngeal carcinoma, epidermoid carcinoma of oropharynx and oral cavity (T1-T4, M0, N0-N3)...
July 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27311894/synthesis-and-cytotoxic-activities-of-semisynthetic-zearalenone-analogues
#18
Kwanruthai Tadpetch, Benyapa Kaewmee, Kittisak Chantakaew, Kawalee Kantee, Vatcharin Rukachaisirikul, Souwalak Phongpaichit
Zearalenone is a β-resorcylic acid macrolide with various biological activities. Herein we report the synthesis and cytotoxic activities of 34 zearalenone analogues against human oral epidermoid carcinoma (KB) and human breast adenocarcinoma (MCF-7) cells as well as noncancerous Vero cells. Some zearalenone analogues showed moderately enhanced cytotoxic activities against the two cancer cell lines. We have discovered the potential lead compounds with diminished or no cytotoxicity to Vero cells. Preliminary structure-activity relationship studies revealed that the double bond at the 1' and 2' positions of zearalenone core was crucial for cytotoxic activities on both cell lines...
August 1, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27133188/optimizing-particle-size-of-docetaxel-loaded-micelles-for-enhanced-treatment-of-oral-epidermoid-carcinoma
#19
Yang Yu, Liyan Qiu
Understanding how the size of nanocarriers affects their fate in biological systems in vivo is of fundamental importance for rational design of drug delivery systems. In this study, five docetaxel (DTX)-loaded methoxy poly(ethylene glycol)-poly(lactide) micelles of different sizes (30-230nm) were prepared. It was observed that the permeation of micelles within both the multicellular tumor spheroids and tumor xenografts in mice was dependent on the size of the micelle. In addition, the size of micelles influenced their pharmacokinetic behavior...
October 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/26444325/eldecalcitol-ed-71-an-analog-of-1%C3%AE-25-dihydroxyvitamin-d3-as-a-potential-anti-cancer-agent-for-oral-squamous-cell-carcinomas
#20
REVIEW
T Shintani, S N Z Rosli, F Takatsu, Y F Choon, Y Hayashido, S Toratani, E Usui, T Okamoto
We have previously reported that 1,25(OH)2D3 inhibits NF-κB activity and thus inhibits growth of OSCC cells in serum-free culture and down-regulates HBp17/FGFBP-1 expression, which is important for cancer cell growth and angiogenesis. Here, we have investigated the effects of ED-71, an analog of vitamin D3 (VD) on OSCC cell lines in serum-free culture. It is known that ED-71 has a stronger inhibitory effect on bone resorption compared to VD and other VD analogs. To the best of our knowledge, there was no report examining the potential of ED-71 as an anti-cancer agent for OSCC...
November 2016: Journal of Steroid Biochemistry and Molecular Biology
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