keyword
MENU ▼
Read by QxMD icon Read
search

Oral epidermoid carcinoma

keyword
https://www.readbyqxmd.com/read/27920642/recurrent-complete-pharyngo-oesophageal-stricture-treated-by-multidisciplinary-anterograde-retrograde-endoscopic-dilation
#1
Paulo Castro Soares, Salim Bouayed, Pavel Dulguerov, Jean-Louis Frossard
Complete pharyngo-oesophageal stricture (PES) after radiotherapy for head and neck cancer is a relatively rare and difficult complication to manage. Historically this condition has been treated surgically, but endoscopic approaches are now available. We present a 61-year-old man with an epidermoid carcinoma of the supraglottic stage and a micro-invasive epidermoid carcinoma of the oropharynx treated surgically and subsequently by adjuvant radiotherapy. Eight months after the end of the radiotherapy, a complete PES was diagnosed and treated with a combined anterograde-retrograde endoscopic dilation (CARD)...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27791423/an-unusual-complication-of-nasolabial-flap-reconstruction
#2
R Mann, B Srinivasan, R Webb, A Webb
Squamous cell carcinoma is the most common carcinoma in the oral cavity. Resection of these cancers often requires reconstruction. Nasolabial flaps are a robust and reliable local flap that provide a satisfactory outcome. We report two cases where an epidermoid cyst developed within the scar of the nasolabial flap and review the literature.
October 28, 2016: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27780132/the-scorpion-venom-peptide-bmkn2-induces-apoptosis-in-cancerous-but-not-in-normal-human-oral-cells
#3
Saranya Satitmanwiwat, Chinarat Changsangfa, Anuson Khanuengthong, Kornkanok Promthep, Sittiruk Roytrakul, Teerakul Arpornsuwan, Kulnasan Saikhun, Hathaitip Sritanaudomchai
AIM: This study aimed to investigate the mechanism of the induction of apoptosis of human oral cancer cells by the scorpion venom peptide BmKn2. METHODS: Human oral squamous carcinoma cells (HSC4), mouth epidermoid carcinoma cells (KB), human normal gingival cells (HGC) and dental pulp cells (DPC) were treated with BmKn-2 peptide for 24h. Cell viability was determined by the MTT assay. Apoptosis was assessed using phase contrast microscopy, by propidium iodide (PI) staining to assess nuclear morphology and by Annexin V staining...
October 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27769871/re-evaluation-of-maml2-fusion-negative-mucoepidermoid-carcinoma-a-subgroup-being-actually-hyalinizing-clear-cell-carcinoma-of-the-salivary-gland-with-ewsr1-translocation
#4
Min-Shu Hsieh, Hsuang Wang, Yi-Hsuan Lee, Jenq-Yuh Ko, Yih-Leong Chang
Hyalinizing clear cell carcinoma (HCCC) is a rare salivary gland tumor with a specific EWSR1-ATF1 fusion gene and can have mucin production. Mucoepidermoid carcinoma (MEC) with a clear cell component is its morphologic mimic. Using MAML2 fluorescence in situ hybridization (FISH), a total of 49 MEC cases were separated into MAML2 fusion-positive (32 cases) and MAML2 fusion-negative groups (17 cases). This study used EWSR1 FISH to investigate MAML2 fusion-negative cases to identify previously unrecognized HCCC...
October 18, 2016: Human Pathology
https://www.readbyqxmd.com/read/27730326/radiotherapy-for-elderly-patients-and-cetuximab-a-monocentric-study
#5
Alexander T Falk, Christophe Hébert, Antoine Tran, Marie-Eve Chand, Axel Leysalle, Juliette Thariat, Olivier Dassonville, Gilles Poissonnet, Alexandre Bozec, Esma Saada, Fréderic Peyrade, Karen Benezery
Concomitant radiotherapy and cetuximab association has shown superiority to exclusive radiotherapy for head and neck cancers. Data on this association are scarce for the elderly population despite its rising incidence. A retrospective monocentric data collection was performed in the Antoine Lacassagne Cancer Center in France. Inclusion criteria were: age >70 years at time of diagnosis, histologically proven head and neck epidermoid carcinoma, treated with radiotherapy combined with cetuximab. Thirty-five patients were included between 2008 and 2012...
October 11, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27649452/synthesis-biological-screening-and-molecular-docking-studies-of-some-tin-iv-schiff-base-adducts
#6
Wajid Rehman, Rehana Yasmeen, Fazal Rahim, Muhammad Waseem, Cun-Yue Guo, Zonera Hassan, Umer Rashid, Khurshid Ayub
The search for an alternative to platinum anticancer agents is a major motivation for continuing investigations concerning the antitumor properties of other transition metal-based compounds. Keeping this in view, synthesis, antitumor and antimicrobial activity of diorganotin (IV) complexes was studied. A novel series of diorganotin (IV) complexes of the Schiff base ligand derived from 7-methoxy-2-hydroxy-1-naphthaldehyde, 1,2-phenylenediamine, Salicylaldehyde were synthesized. Physical and spectral examination was done through various techniques using elemental analyses, IR, (1)H, (13)C, (119)Sn NMR, and (119m)Sn Mössbauer techniques respectively...
September 13, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27416556/rosiglitazone-elevates-sensitization-of-drug-resistant-oral-epidermoid-carcinoma-cells-to-vincristine-by-g2-m-phase-arrest-independent-of-ppar-%C3%AE-pathway
#7
Hong-Yuan Wang, Ying Zhang, Yue Zhou, Yu-Yin Lu, Wen-Fang Wang, Ming Xin, Xiu-Li Guo
Rosiglitazone (ROSI), an oral antidiabetic agent, has been reported the anti-cancer properties recent years. In this paper, the potency of ROSI as a synergistic drug for vincristine (VCR) on resistant oral cancer cells was investigated. We found that ROSI potently enhanced the susceptibility of KB cells or KB/V cells to VCR in a dose manner and the synergy in KB/V cells was much more prominent than that in KB cells. The synergistic anti-proliferative effect of ROSI and VCR was associated with inhibition on tubulin polymerization, cell cycle arrest in G2/M phase and cell apoptosis induction, but has no effect on drug efflux-protein P-gp and was independent with PPARγ...
July 11, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27345843/toxicity-and-efficacy-of-cetuximab-associated-with-several-modalities-of-imrt-for-locally-advanced-head-and-neck-cancer
#8
J-E Bibault, M Morelle, L Perrier, P Pommier, P Boisselier, B Coche-Dequéant, O Gallocher, M Alfonsi, É Bardet, M Rives, V Calugaru, E Chajon, G Noël, H Mecellem, D Pérol, S Dussart, P Giraud
PURPOSE: Intensity-modulated radiation therapy (IMRT) has shown its interest for head and neck cancer treatment. In parallel, cetuximab has demonstrated its superiority against exclusive radiotherapy. The objective of this study was to assess the acute toxicity, local control and overall survival of cetuximab associated with different IMRT modalities compared to platinum-based chemotherapy and IMRT in the ARTORL study (NCT02024035). PATIENTS AND METHOD: This prospective, multicenter study included patients with epidermoid or undifferentiated nasopharyngeal carcinoma, epidermoid carcinoma of oropharynx and oral cavity (T1-T4, M0, N0-N3)...
July 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27311894/synthesis-and-cytotoxic-activities-of-semisynthetic-zearalenone-analogues
#9
Kwanruthai Tadpetch, Benyapa Kaewmee, Kittisak Chantakaew, Kawalee Kantee, Vatcharin Rukachaisirikul, Souwalak Phongpaichit
Zearalenone is a β-resorcylic acid macrolide with various biological activities. Herein we report the synthesis and cytotoxic activities of 34 zearalenone analogues against human oral epidermoid carcinoma (KB) and human breast adenocarcinoma (MCF-7) cells as well as noncancerous Vero cells. Some zearalenone analogues showed moderately enhanced cytotoxic activities against the two cancer cell lines. We have discovered the potential lead compounds with diminished or no cytotoxicity to Vero cells. Preliminary structure-activity relationship studies revealed that the double bond at the 1' and 2' positions of zearalenone core was crucial for cytotoxic activities on both cell lines...
August 1, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27133188/optimizing-particle-size-of-docetaxel-loaded-micelles-for-enhanced-treatment-of-oral-epidermoid-carcinoma
#10
Yang Yu, Liyan Qiu
Understanding how the size of nanocarriers affects their fate in biological systems in vivo is of fundamental importance for rational design of drug delivery systems. In this study, five docetaxel (DTX)-loaded methoxy poly(ethylene glycol)-poly(lactide) micelles of different sizes (30-230nm) were prepared. It was observed that the permeation of micelles within both the multicellular tumor spheroids and tumor xenografts in mice was dependent on the size of the micelle. In addition, the size of micelles influenced their pharmacokinetic behavior...
April 29, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/26444325/eldecalcitol-ed-71-an-analog-of-1%C3%AE-25-dihydroxyvitamin-d3-as-a-potential-anti-cancer-agent-for-oral-squamous-cell-carcinomas
#11
T Shintani, S N Z Rosli, F Takatsu, Y F Choon, Y Hayashido, S Toratani, E Usui, T Okamoto
We have previously reported that 1,25(OH)2D3 inhibits NF-κB activity and thus inhibits growth of OSCC cells in serum-free culture and down-regulates HBp17/FGFBP-1 expression, which is important for cancer cell growth and angiogenesis. Here, we have investigated the effects of ED-71, an analog of vitamin D3 (VD) on OSCC cell lines in serum-free culture. It is known that ED-71 has a stronger inhibitory effect on bone resorption compared to VD and other VD analogs. To the best of our knowledge, there was no report examining the potential of ED-71 as an anti-cancer agent for OSCC...
October 9, 2015: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/26222425/folate-containing-reduction-sensitive-lipid-polymer-hybrid-nanoparticles-for-targeted-delivery-of-doxorubicin
#12
Bo Wu, Ping Yu, Can Cui, Ming Wu, Yang Zhang, Lei Liu, Cai-Xia Wang, Ren-Xi Zhuo, Shi-Wen Huang
The development and evaluation of folate-targeted and reduction-triggered biodegradable nanoparticles are introduced to the research on targeted delivery of doxorubicin (DOX). This type of folate-targeted lipid-polymer hybrid nanoparticles (FLPNPs) is comprised of a poly(D,L-lactide-co-glycolide) (PLGA) core, a soybean lecithin monolayer, a monomethoxy-poly(ethylene glycol)-S-S-hexadecyl (mPEG-S-S-C16) reduction-sensitive shell, and a folic acid-targeted ligand. FLPNPs exhibited high size stability but fast disassembly in a simulated cancer cell reductive environment...
April 2015: Biomaterials Science
https://www.readbyqxmd.com/read/26141206/peritumoral-infiltrate-in-the-prognosis-of-epidermoid-carcinoma-of-the-oral-cavity
#13
Vivian Regina Affonso, José Raphael de Moura Campos Montoro, Luiz Carlos Conti de Freitas, Fabiano Pinto Saggioro, Luiz de Souza, Rui Celso Martins Mamede
INTRODUCTION: Patients with squamous cell carcinoma of the oral cavity present deficits in their cellular immunity that contribute to neoplastic growth. Thus, the inflammatory activity, such as the immunological response to the tumor, can be used as a prognostic factor. OBJECTIVES: To evaluate the correlation between peritumoral inflammation and clinical characteristics of the patients, survival, and the disease-free interval. METHODS: The study sample consisted of a retrospective hospital-based cohort of patients undergoing surgery for resection of oral cavity tumor...
July 2015: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/26129936/protective-activity-of-biflavanones-from-garcinia-kola-against-plasmodium-infection
#14
Benetode Konziase
ETHNOPHARMACOLOGICAL RELEVANCE: Garcinia kola is a medicinal plant traditionally used for malaria therapy in Central Africa. AIM OF THE STUDY: To evaluate the antimalarial potencies in vitro and in vivo of pure biflavanones from G. kola. MATERIALS AND METHODS: The pure biflavanones were obtained by bioassay-guided fractionation of a 70% ethanol extract of G. kola seeds and their chemical structures were elucidated by comparison of their NMR ((1)H and (13)C) and mass spectral data with those provided in the literature...
August 22, 2015: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/25879368/platelet-derived-growth-factor-type-bb-and-collagen-matrix-for-soft-tissue-reconstruction-after-muco-epidermoid-carcinoma-removal-a-possible-therapeutic-option
#15
Marco Cicciù, Alan Scott Herford, Vecchio Giada Maria, Ennio Bramanti
Muco-epidermoid carcinoma (MEC) is a rare malignant tumor occurring in major and minor salivary glands. The described case shows a patient undergoing tumor resection without neck dissection. A quick diagnosis performed through clinical investigation and incisional biopsy revealed the nature of the tumor. A porcine collagen matrix was applied after the surgery in order to improve soft tissue healing. The matrix was saturated with platelet-derived growth factor type BB in order to favorite healing process and then fixed on the palate with a dental support device...
January 2015: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/25869317/natural-flavonoid-derivatives-as-oral-human-epidermoid-carcinoma-cell-inhibitors
#16
Shravan Kumar Gunda, Sofia Florence Kongaleti, Mahmood Shaik
Natural flavonoid derivatives against cancer for selective KB cell lines (oral human epidermoid carcinoma) are analysed to determine the relationship between biological activities and structural properties of these molecules. Molecular alignment was performed for 88 natural flavonoid derivatives; out of these 88 molecules, 69 molecules were taken into training set and rest of the 19 molecules were used in test set prediction. We describe our elucidation of their structure activity relation (SAR) using three-dimensional quantitative structure activity relationship (3D-QSAR) models...
2015: International Journal of Computational Biology and Drug Design
https://www.readbyqxmd.com/read/25532278/dammarane-terpenoids-from-the-fruits-of-dysoxylum-mollissimum
#17
Cholpisut Tantapakul, Wisanu Maneerat, Tawanun Sripisut, Thunwadee Ritthiwigrom
Two new dammaranes, dysomollisol (1) and dysomollisone (2), along with seven known compounds (3-9) were isolated and identified from the fruits of Dysoxylum mollissimum. The structures of these compounds were determined on the basis of spectroscopic analyses, including 1D and 2D NMR, UV, IR and mass spectrometry. The antibacterial activity and cytotoxicity against epidermoid carcinoma of oral cavity (KB) cell line of compounds 1-9 were evaluated.
November 2014: Natural Product Communications
https://www.readbyqxmd.com/read/25368229/blue-light-activates-phase-2-response-proteins-and-slows-growth-of-a431-epidermoid-carcinoma-xenografts
#18
Alpesh D Patel, Shaun Rotenberg, Regina L W Messer, John C Wataha, Kalu U E Ogbureke, Veronica V McCloud, Petra Lockwood, Stephen Hsu, Jill B Lewis
BACKGROUND: Recent studies suggest that light in the UVA range (320-400 nm) activates signaling pathways that are anti-inflammatory, antioxidative and play a critical role in protection against cancer. These effects have been attributed to NF-E2-related factor (NRF2)-mediated up-regulation of 'phase 2' genes that neutralize oxidative stress and metabolize electrophiles. We had previously shown that small doses of blue light (400-500 nm) had selective toxicity for cultured oral tumor cells and increased levels of peroxiredoxin phase 2 proteins, which led to our hypothesis that blue light activates NRF2 signaling...
November 2014: Anticancer Research
https://www.readbyqxmd.com/read/25136105/robustness-against-serum-neutralization-of-a-poliovirus-type-1-from-a-lethal-epidemic-of-poliomyelitis-in-the-republic-of-congo-in-2010
#19
Jan Felix Drexler, Gilda Grard, Alexander N Lukashev, Liubov I Kozlovskaya, Sindy Böttcher, Gökhan Uslu, Johan Reimerink, Anatoly P Gmyl, Raphaël Taty-Taty, Sonia Etenna Lekana-Douki, Dieudonné Nkoghe, Anna M Eis-Hübinger, Sabine Diedrich, Marion Koopmans, Eric M Leroy, Christian Drosten
In 2010, a large outbreak of poliomyelitis with unusual 47% lethality occurred in Pointe Noire, Republic of Congo. Vaccine-mediated immunity against the outbreak virus was never investigated. A wild poliovirus 1 (WPV1) isolated from a fatal case (termed PV1-RC2010) showed a previously unknown combination of amino acid exchanges in critical antigenic site 2 (AgS2, VP1 capsid protein positions 221SAAL → 221PADL). These exchanges were also detected in an additional 11 WPV1 strains from fatal cases. PV1-RC2010 escaped neutralization by three different mAbs relevant for AgS2...
September 2, 2014: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/25087653/cutaneous-and-oral-squamous-cell-carcinoma-dual-immunosuppression-via-recruitment-of-foxp3-regulatory-t-cells-and-endogenous-tumour-foxp3-expression
#20
Stephanie Schipmann, Kai Wermker, Hans-Joachim Schulze, Johannes Kleinheinz, Georg Brunner
Regulatory T cells (Tregs) are an essential component of the immune system, but are also involved in the suppression of anti-tumour immune responses. The study examines their immunoregulatory role including their transcription factor, FOXP3, in oral and cutaneous SCC. Tregs were detected by double-immunohistochemistry. FOXP3-mRNA-expression was examined in tumour tissue, as well as in skin-derived primary cells and cell lines of different malignancy. Tregs were found in the tumour microenvironment, and FOXP3-mRNA-expression was significantly higher than in normal skin...
December 2014: Journal of Cranio-maxillo-facial Surgery
keyword
keyword
41974
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"