keyword
MENU ▼
Read by QxMD icon Read
search

Motor disorder

keyword
https://www.readbyqxmd.com/read/29036819/age-and-graphomotor-decision-making-assessed-with-the-digital-clock-drawing-test-the-framingham-heart-study
#1
Ryan J Piers, Kathryn N Devlin, Boting Ning, Yulin Liu, Ben Wasserman, Joseph M Massaro, Melissa Lamar, Catherine C Price, Rod Swenson, Randall Davis, Dana L Penney, Rhoda Au, David J Libon
BACKGROUND: Digital Clock Drawing Test (dCDT) technology enables the examination of detailed neurocognitive behavior as behavior unfolds in in real time; a capability that cannot be obtained using a traditional pen and paper testing format. OBJECTIVE: Parameters obtained from the dCDT were used to investigate neurocognitive constructs related to higher-order neurocognitive decision-making and information processing speed. The current research sought to determine the effect of age as related to combined motor and non-motor components of drawing, and higher-order, decision-making latencies...
October 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036632/mapping-compulsivity-in-the-dsm-5-obsessive-compulsive-and-related-disorders-cognitive-domains-neural-circuitry-and-treatment
#2
Naomi A Fineberg, Annemieke M Apergis-Schoute, M Matilde Vaghi, Paula Banca, Claire M Gillan, Valerie Voon, Samuel R Chamberlain, Cinosi Eduardo, Reid Jemma, Sonia Shahper, Edward T Bullmore, Barbara J Sahakian, Trevor W Robbins
Compulsions are repetitive, stereotyped thoughts and behaviors designed to reduce harm. Growing evidence suggests that the neurocognitive mechanisms mediating behavioural inhibition (motor inhibition, cognitive inflexibility) reversal learning and habit formation (shift from goal-directed to habitual responding) contribute toward compulsive activity in a broad range of disorders. In obsessive compulsive disorder (OCD), distributed network perturbation appears focussed around the pre-frontal cortex, caudate, putamen and associated neuro-circuitry...
September 23, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29035887/valeriana-officinalis-root-extract-modulates-cortical-excitatory-circuits-in-humans
#3
Ludovico Mineo, Carmen Concerto, Dhaval Patel, Tyrone Mayorga, Michael Paula, Eileen Chusid, Eugenio Aguglia, Fortunato Battaglia
BACKGROUND: Valeriana officinalis extract (VE) is a popular herbal medicine used for the treatment of anxiety and sleep disorders. Although the anxiolytic and sedative effects are mainly attributed to the modulation of GABA-ergic transmission, the mechanism of action has not been fully investigated in humans. Noninvasive brain stimulation protocols can be used to elucidate the mechanisms of action of psychoactive substances at the cortical level in humans. In this study, we investigated the effects of a single dose of VE on cortical excitability as assessed with transcranial magnetic stimulation (TMS)...
October 17, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/29034894/induced-pluripotent-stem-cells-derived-from-a-patient-with-familial-idiopathic-basal-ganglia-calcification-ibgc-caused-by-a-mutation-in-slc20a2-gene
#4
Shin-Ichiro Sekine, Takayuki Kondo, Nagahisa Murakami, Keiko Imamura, Takako Enami, Ran Shibukawa, Kayoko Tsukita, Misato Funayama, Masatoshi Inden, Hisaka Kurita, Isao Hozumi, Haruhisa Inoue
Idiopathic basal ganglia calcification (IBGC), also known as Fahr disease or primary familial brain calcifications (PFBC), is a rare neurodegenerative disorder characterized by calcium deposits in basal ganglia and other brain regions, causing neuropsychiatric and motor symptoms. We established human induced pluripotent stem cells (iPSCs) from an IBGC patient. The established IBGC-iPSCs carried SLC20A2 c.1848G>A mutation (p.W616* of translated protein PiT2), and also showed typical iPSC morphology, pluripotency markers, normal karyotype, and the ability of in vitro differentiation into three-germ layers...
October 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29034646/index-of-theta-alpha-ratio-of-the-quantitative-electroencephalogram-in-alzheimer-s-disease-a-case-control-study
#5
Golshan Fahimi, Seyed Mahmoud Tabatabaei, Elnaz Fahimi, Hamid Rajebi
Alzheimer's disease (AD) is a devastating neurodegenerative disorder in human beings associated with cognitive, behavioral and motor impairments. The main symptom of AD is dementia, which causes difficulties in carrying out daily practices. Brain waves are altered in people with AD. Relative indices of brain waves can be beneficial in the diagnosis of AD. In this case-control study, 50 patients with AD and 50 matched healthy individuals were enrolled in case and control groups respectively. With recording and analyzing of brain waves with the utilization of quantitative electroencephalogram (QEEG), index of theta/alpha ratio was assessed in both groups...
August 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29033857/an-update-overview-on-brain-imaging-studies-of-internet-gaming-disorder
#6
REVIEW
Aviv M Weinstein
There are a growing number of studies on structural and functional brain mechanisms underlying Internet gaming disorder (IGD). Recent functional magnetic resonance imaging studies showed that IGD adolescents and adults had reduced gray matter volume in regions associated with attention motor coordination executive function and perception. Adolescents with IGD showed lower white matter (WM) integrity measures in several brain regions that are involved in decision-making, behavioral inhibition, and emotional regulation...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29033792/spontaneous-and-evoked-activity-from-murine-ventral-horn-cultures-on-microelectrode-arrays
#7
Bryan J Black, Rahul Atmaramani, Joseph J Pancrazio
Motor neurons are the site of action for several neurological disorders and paralytic toxins, with cell bodies located in the ventral horn (VH) of the spinal cord along with interneurons and support cells. Microelectrode arrays (MEAs) have emerged as a high content assay platform for mechanistic studies and drug discovery. Here, we explored the spontaneous and evoked electrical activity of VH cultures derived from embryonic mouse spinal cord on multi-well plates of MEAs. Primary VH cultures from embryonic day 15-16 mice were characterized by expression of choline acetyltransferase (ChAT) by immunocytochemistry...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29033643/dandy-walker-malformation-presenting-with-affective-symptoms
#8
Mert Batmaz, Zeynep Ezgi Balçik, Ürün Özer, Burcu Hamurişçi Yalçin, Şakir Özen
Dandy-Walker malformation is defined by enlarged posterior fossa, cystic dilatation of the fourth ventricle, and cerebellar hypoplasia. Although developmental delay and mental retardation are common in Dandy-Walker malformation cases, other comorbid psychiatric conditions have been rarely reported. There are limited numbers of case reports about comorbidity of bipolar disorder with Dandy-Walker malformation in the literature. Herein, a Dandy-Walker malformation case presenting affective symptoms is reported, and psychiatric symptoms which might be seen in this rare malformation are discussed along with diagnosis, treatment, and follow-up processes...
September 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29032428/usability-operations-on-touch-mobile-devices-for-users-with-autism
#9
Angeles Quezada, Reyes Juárez-Ramírez, Samantha Jiménez, Alan Ramírez Noriega, Sergio Inzunza, Arnulfo Alanis Garza
The Autistic Spectrum Disorder is a cognitive disorder that affects the cognitive and motor skills; due that, users cannot perform digital and fine motor tasks. It is necessary to create software applications that adapt to the abilities of these users. In recent years has been an increase in the research of the use of technology to support autistic users to develop their communication skills and to improve learning. However, the applications' usability for disable users is not assessed objectively as the existing models do not consider interaction operators for disable users...
October 14, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29031989/chn1-gene-mutation-analysis-in-patients-with-duane-s-retraction-syndrome
#10
Elif Demirkilinc Biler, Orhan Ilim, Huseyin Onay, Onder Uretmen
PURPOSE: To investigate CHN1 (chimerin 1) gene mutations in patients with isolated nonsyndromic Duane syndrome and accompanying positive familial history, bilaterality, or various systemic disorders. METHODS: Patients with Duane retraction syndrome (DRS) and a positive family history of congenital ocular motility disturbance or bilateral involvement or accompanying any congenital disorder(s) seen consecutively at a single center from 2013 to 2016 were enrolled. All subjects underwent full ophthalmologic examination, including refraction, best-corrected visual acuity, ocular alignment and motility, globe retraction, and biomicroscopic or fundus evaluation...
October 12, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29031901/als-and-ftd-insights-into-the-disease-mechanisms-and-therapeutic-targets
#11
Rajka M Liscic
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative disorders, related by signs of deteriorating motor and cognitive functions, and short survival. The causes are still largely unknown and no effective treatment currently exists. It has been shown that FTLD may coexist with ALS. The overlap between ALS and frontotemporal dementia (FTD), the clinical syndrome associated with FTLD, occurs at clinical, genetic, and pathological levels. The hallmark proteins of the pathognomonic inclusions are SOD-1, TDP-43 or FUS, rarely the disease is caused by mutations in the respective genes...
October 11, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29031463/changes-in-brain-activity-during-action-observation-and-motor-imagery-their-relationship-with-motor-learning
#12
Nobuaki Mizuguchi, Kazuyuki Kanosue
Many studies have demonstrated that training utilizing action observation and/or motor imagery improves motor performance. These two techniques are widely used in sports and in the rehabilitation of movement-related disorders. Motor imagery has also been used for brain-machine/computer interfaces (BMI/BCI). During both action observation and motor imagery, motor-related regions such as the premotor cortex and inferior parietal lobule are activated. This is common to actual execution and are involved with the underlying mechanisms of motor learning without execution...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/29031008/identification-of-a-novel-homozygous-trappc9-gene-mutation-causing-non-syndromic-intellectual-disability-speech-disorder-and-secondary-microcephaly
#13
Ansar A Abbasi, Kathrin Blaesius, Hao Hu, Zahid Latif, Sylvie Picker-Minh, Muhammad N Khan, Sundas Farooq, Muzammil A Khan, Angela M Kaindl
TRAPPC9 gene mutations have been linked recently to autosomal recessive mental retardation 13 (MRT13; MIM#613192) with only eight families reported world-wide. We assessed patients from two consanguineous pedigrees of Pakistani descent with non-syndromic intellectual disability and postnatal microcephaly through whole exome sequencing (WES) and cosegregation analysis. Here we report six further patients from two pedigrees with homozygous TRAPPC9 gene mutations, the novel nonsense mutation c.2065G>T (p.E689*) and the previously identified nonsense mutation c...
October 14, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29030688/neurotrophic-function-of-phytochemicals-for-neuroprotection-in-aging-and-neurodegenerative-disorders-modulation-of-intracellular-signaling-and-gene-expression
#14
REVIEW
Makoto Naoi, Keiko Inaba-Hasegawa, Masayo Shamoto-Nagai, Wakako Maruyama
Bioactive compounds in food and beverages have been reported to promote health and prevent age-associated decline in cognitive, motor and sensory activities, and emotional function. Phytochemicals, a ubiquitous class of plant secondary metabolites, protect neuronal cells by interaction with cellular activities, in addition to the antioxidant and anti-inflammatory function. In aging and age-associated neurodegenerative disorders, phytochemicals protect neuronal cells by neurotrophic factor-mimic activity, in addition to suppression of apoptosis signaling in mitochondria...
October 13, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29030452/longitudinal-csf-biomarkers-in-patients-with-early-parkinson-disease-and-healthy-controls
#15
Brit Mollenhauer, Chelsea J Caspell-Garcia, Christopher S Coffey, Peggy Taylor, Leslie M Shaw, John Q Trojanowski, Andy Singleton, Mark Frasier, Kenneth Marek, Douglas Galasko
OBJECTIVE: To analyze longitudinal levels of CSF biomarkers in drug-naive patients with Parkinson disease (PD) and healthy controls (HC), examine the extent to which these biomarker changes relate to clinical measures of PD, and identify what may influence them. METHODS: CSF α-synuclein (α-syn), total and phosphorylated tau (t- and p-tau), and β-amyloid 1-42 (Aβ42) were measured at baseline and 6 and 12 months in 173 patients with PD and 112 matched HC in the international multicenter Parkinson's Progression Marker Initiative...
October 13, 2017: Neurology
https://www.readbyqxmd.com/read/29030055/the-heart-of-pd-lewy-body-diseases-as-neurocardiologic-disorders
#16
David S Goldstein, Yehonatan Sharabi
This review provides an update about cardiac sympathetic denervation in Lewy body diseases. The family of Lewy body diseases includes Parkinson's disease (PD), pure autonomic failure (PAF), and dementia with Lewy bodies (DLB). All three feature intra-neuronal cytoplasmic deposits of the protein, alpha-synuclein. Multiple system atrophy (MSA), the parkinsonian form of which can be difficult to distinguish from PD with orthostatic hypotension, involves glial cytoplasmic inclusions that contain alpha-synuclein...
October 10, 2017: Brain Research
https://www.readbyqxmd.com/read/29029552/using-rasch-analysis-to-validate-the-motor-activity-log-and-the-lower-functioning-motor-activity-log-in-patients-with-stroke
#17
I-Ching Chuang, Keh-Chung Lin, Ching-Yi Wu, Yu-Wei Hsieh, Chien-Ting Liu, Chia-Ling Chen
Background: The Motor Activity Log (MAL) and Lower-Functioning MAL (LF-MAL) are used to assess the amount of use of the more impaired arm and the quality of movement during activities in real-life situations for patients with stroke. Objective: This study used Rasch analysis to examine the psychometric properties of the MAL and LF-MAL in patients with stroke. Design: This is a methodological study. Methods: The MAL and LF-MAL include 2 scales: the amount of use (AOU) and the quality of movement (QOM)...
October 1, 2017: Physical Therapy
https://www.readbyqxmd.com/read/29029362/altered-tdp-43-dependent-splicing-in-hspb8-related-distal-hereditary-motor-neuropathy-and-myofibrillar-myopathy
#18
Andrea Cortese, Matilde Laurà, Carlo Casali, Ichizo Nishino, Yukiko K Hayashi, Stefania Magri, Franco Taroni, Cristiana Stuani, Paola Saveri, Maurizio Moggio, Michela Ripolone, A Prelle, C Pisciotta, A Sagnelli, Anna Pichiecchio, Mary M Reilly, Emanuele Buratti, Davide Pareyson
INTRODUCTION: Mutations in the small heat shock protein 22 gene (HSPB8) have been associated with Charcot-Marie-Tooth type 2L, distal hereditary motor neuropathy (dHMN) type IIa and, more recently, distal myopathy/myofibrillar myopathy (MFM) with protein aggregates and TDP-43 inclusions. OBJECTIVE: To report a novel family with HSPB8 (K141E) -related dHMN/MFM and to investigate, in a patient muscle biopsy, whether the presence of protein aggregates was paralleled by altered TDP-43 function...
October 13, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29028865/clinical-ethics-in-the-context-of-deep-brain-stimulation-for-movement-disorders
#19
Cynthia S Kubu, Paul J Ford
Objective: Discuss common clinical ethical challenges encountered in working with patients who are candidates for deep brain stimulation (DBS) for the treatment of motor symptoms of Parkinson's disease (PD). Method: The relevant literature is reviewed and supplemented by descriptive, ethically challenging cases stemming from decades of combined experience working on DBS teams. We outline ethical arguments and provide pragmatic recommendations to assist neuropsychologists working in movement disorder teams...
September 25, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29028627/local-dynamic-stability-during-treadmill-walking-can-detect-children-with-developmental-coordination-disorder
#20
Merete B Speedtsberg, Sofie B Christensen, Jan Stenum, Thomas Kallemose, Jesper Bencke, Derek J Curtis, Bente R Jensen
OBJECTIVE: Developmental coordination disorder (DCD) is an innate impairment of motor coordination that affects basic locomotion and balance. This study investigated local dynamic stability of trunk accelerations during treadmill walking as an objective evaluation of gait stability and the sensitivity and specificity of this measure to discriminate children with DCD from typically developing children. METHOD: Eight children with DCD and ten age- and gender-matched typically developing children (TD) walked four minutes on a treadmill...
October 5, 2017: Gait & Posture
keyword
keyword
41971
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"