keyword
MENU ▼
Read by QxMD icon Read
search

Name

keyword
https://www.readbyqxmd.com/read/29458230/perioperative-complications-of-congenital-diaphragmatic-hernia-repair
#1
Catarina Barroso, Jorge Correia-Pinto
Although improvements have been made, the management of congenital diaphragmatic hernia (CDH) remains a major challenge for perinatologists and neonatal surgeons. Many aspects of the disease remain unknown and, being a rare entity, evidence-based data are hard to find. Surgical morbidity is considerable and affects long-term quality of life. Perioperative complications have been reviewed focusing on thoracoscopic repair. Intraoperative acidosis was more severe during thoracoscopy when compared with open surgery (OS), though it is possible that later neurodevelopment was not affected...
February 19, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29458204/a-review-of-implantable-biosensors-for-closed-loop-glucose-control-and-other-drug-delivery-applications
#2
Kee Scholten, Ellis Meng
Closed-loop drug delivery promises autonomous control of pharmacotherapy through the continuous monitoring of biomarker levels. For decades, researchers have strived for portable closed-loop systems, capable of treating ambulatory patients with chronic conditions such as diabetes mellitus. After years of development, the first of these systems have left the laboratory and entered commercial use. This long-awaited advance reflects recent development of chronically stable implantable biosensors, able to accurately measure biomarker levels in vivo...
February 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29458146/enhanced-anticancer-effects-of-scutellaria-barbata-d-don-in-combination-with-traditional-chinese-medicine-components-on-non-small-cell-lung-cancer-cells
#3
Qian Wang, Narayan Acharya, Zhongwei Liu, Xianmei Zhou, Meghan Cromie, Jia Zhu, Weimin Gao
ETHNOPHARMACOLOGICAL RELEVANCE: Experience-based herbal medicine as a complementary to modern western medicine has triggered an array of studies in quest of novel anticancer drugs. Scutellaria barbata D. Don (SB) is commonly used to treat different types of cancers, but its molecular mechanism of action is not clearly understood. In this study, we attempted to elucidate the mode of action of a traditional Chinese medicine prescription with a total of 14 components, named Lian-Jia-San-Jie-Fang (LJSJF, in Chinese), where SB works as the "principle" against non-small cell lung cancer (NSCLC) cells...
February 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29458138/pharmacokinetic-and-pharmacodynamic-evaluation-of-5-methoxy-2-aminoindane-meai-a-new-binge-mitigating-agent
#4
Jakob A Shimshoni, Eyal Sobol, Ezekiel Golan, Yulius Ben Ari, Orit Gal
5-Methoxy-2-aminoindane (MEAI) is a novel psychoactive aminoindane derivative, exerting euphoric, alcohol-like tipsy experience and reduced desire to consume alcoholic beverages. Our previous toxicological evaluation of MEAI in rats, clearly indicated MEAI's potential to be further evaluated as a promising binge mitigating agent due to its favorable safety profile. In the light of these observations, we have determined MEAI's pharmacokinetic (PK) profile in rats and evaluated in-vitro its pharmacodynamics (PD) profile...
February 16, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29457979/the-samholides-swinholide-related-metabolites-from-a-marine-cyanobacterium-cf-phormidium-sp
#5
Yiwen Tao, Pinglin Li, Daojing Zhang, Evgenia Glukhov, Lena Gerwick, Chen Zhang, Thomas F Murray, William H Gerwick
Cancer cell cytotoxicity was used to guide the isolation of nine new swinholide-related compounds, named samholides A-I (1-9), from an American Samoan marine cyanobacterium cf. Phormidium sp. Their structures were determined by extensive analysis of 1D and 2D NMR spectroscopic data. The new compounds share an unusual 20-demethyl 44-membered lactone ring comprised of two monomers, and they demonstrate structural diversity arising from geometric isomerization of double bonds, sugar units with unique glyceryl moieties and varied methylation patterns...
February 19, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29457878/genetic-determinants-of-heart-failure-facts-and-numbers
#6
EDITORIAL
Frauke S Czepluch, Bernd Wollnik, Gerd Hasenfuß
The relevance of gene mutations leading to heart diseases and hence heart failure has become evident. The risk for and the course of heart failure depends on genomic variants and mutations underlying the so-called genetic predisposition. Genetic contribution to heart failure is highly heterogenous and complex. For any patient with a likely inherited heart failure syndrome, genetic counselling is recommended and important. In the last few years, novel sequencing technologies (named next-generation sequencing - NGS) have dramatically improved the availability of molecular testing, the efficiency of genetic analyses, and moreover reduced the cost for genetic testing...
February 19, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29457875/variations-of-the-circle-of-willis-at-the-end-of-the-human-embryonic-period
#7
Kana Furuichi, Aoi Ishikawa, Chigako Uwabe, Haruyuki Makishima, Shigehito Yamada, Tetsuya Takakuwa
Variations of the circle of Willis (CW) influence blood supply to the brain and adjacent structures in adults. We examined the formation of the CW in 20 human embryo samples at the end of the embryonic period using 3-D reconstructions of serial histological sections. The CW was closed in all samples, and did not form in a single plane, but was composed of multiple stair-like planes. The artery acutely curved at the caudal part of the CW, namely at the inlet of the basilar artery and bifurcation of the P1 segment of the posterior cerebral artery (PCA), reflecting flexure of the mesencephalon and diencephalon at this stage...
February 19, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29457860/controlling-the-outgrowth-and-functions-of-neural-stem-cells-the-effect-of-surface-topography
#8
REVIEW
Chara Simitzi, Kanelina Karali, Anthi Ranella, Emmanuel Stratakis
Neural stem cells (NSCs) are self-renewing cells that generate the major cell types of the central nervous system, namely neurons, astrocytes and oligodendrocytes, during embryonic development and in the adult brain. NSCs reside in a complex niche where they are exposed to a plethora of signals, including both soluble and physical signals such as compressive and shear stresses, but also discontinuities and differences in morphology of the extracellular environment, termed as topographical features. Different approaches that incorporate artificial micro- and nano-scale surface topographical features have been developed aiming to recapitulate the in vivo NSC niche discontinuities and features, particularly for in vitro studies...
February 19, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29457837/improved-wound-remodeling-correlates-with-modulated-tgf-beta-expression-in-skin-diabetic-wounds-following-combined-red-and-infrared-photobiomodulation-treatments
#9
Reza Fekrazad, Arash Sarrafzadeh, Katayoun Am Kalhori, Imran Khan, Praveen R Arany, Alessio Giubellino
Diabetic wounds are a major cause of morbidity among patients with poorly controlled blood glucose levels. Conventional empirical wound care strategies have shown limited efficacy and there is an urgent need to develop novel therapeutic strategies. Photobiomodulation treatments have shown a positive therapeutic effects in several cell culture and animal models. In this study, we examined wound healing in diabetic rats following treatments with two laser wavelengths, namely red (660nm) and infrared (808nm) individually and in combination as compared to routine wound dressings...
February 19, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29457806/enhancement-of-the-selectivity-of-mxenes-m-2-c-m-ti-v-nb-mo-via-oxygen-functionalization-promising-materials-for-gas-sensing-and-separation
#10
A Junkaew, R Arróyave
Two-dimensional graphene-like materials, namely MXenes, have been proposed as potential materials for various applications. In this work, the reactivity and selectivity of four MXenes (i.e. M2 C (M = Ti, V, Nb, Mo)) and their oxygen-functionalized forms (i.e. O-MXenes or M2 CO2 ) toward gas molecules were investigated by using the plane wave-based Density Functional Theory (DFT) calculations. Small gas molecules, which are commonly found in flue gas streams, are considered herein. Our results demonstrated that MXenes are very reactive...
February 19, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29457761/degradation-of-anti-inflammatory-drugs-in-municipal-wastewater-by-heterogeneous-photocatalysis-and-electro-fenton-process
#11
Minerva Villanueva-Rodríguez, Ricardo Bello-Mendoza, Aracely Hernández-Ramírez, Edgar J Ruiz-Ruiz
Non-steroidal anti-inflammatory drugs (NSAID) are compounds frequently found in municipal wastewater and their degradation by conventional wastewater treatment plants (WWTP) is generally incomplete. This study compared the efficiency of two advanced oxidation processes, namely heterogeneous photocatalysis (HP) and electro-Fenton (EF), in the degradation of a mixture of common NSAID (diclofenac, ibuprofen and naproxen) dissolved in either deionized water or effluent from a WWTP. Both processes were effective in degrading the NSAID mixture and the trend of degradation was as follows, diclofenac>naproxen>ibuprofen...
February 19, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29457754/effect-of-ship-hull-form-on-the-resistance-penalty-from-biofouling
#12
Dinis Oliveira, Ann I Larsson, Lena Granhag
Hull biofouling is a well-known problem for the shipping industry, leading to increased resistance and fuel consumption. Considering that the effects of hull form on resistance are known to be higher for a less slender hull, it is hypothesised in this paper that the effect of biofouling roughness on resistance is also dependent on the hull form. To test this hypothesis, previously reported full-scale numerical results on a containership are re-analysed. Form effects on roughness penalties, corresponding to KΔCT = 0...
February 19, 2018: Biofouling
https://www.readbyqxmd.com/read/29457748/structural-determination-of-two-new-acacic-acid-type-saponins-from-the-stem-barks-of-albizia-zygia-dc-j-f-macbr
#13
Olivier Placide Noté, Line Made Simo, Joséphine Ngo Mbing, Dominique Guillaume, Christian Dominique Muller, Dieudonné Emmanuel Pegnyemb, Annelise Lobstein
As a continuation of our interest in the study of triterpenoid saponins from Albizia zygia, phytochemical investigation of its stem barks led to the isolation of two new oleanane-type saponins, named zygiaosides C-D (1-2). Their structures were established on the basis of extensive analysis of 1D and 2D NMR (1H-, 13C NMR, DEPT, COSY, TOCSY, ROESY, HSQC and HMBC) experiments, HRESIMS studies, and by chemical evidence as, 3-O-[ β-d-glucopyranosyl-(1→2)-[α-l-arabinopyranosyl-(1→6)]-β-d-glucopyranosyl]-21-O-[(2E,6S)-2,6-dimethyl-6-O-(β-d-quinovopyranosyl) octa-2,7-dienoyl]acacic acid 28-O-α-l-arabinofuranosyl-(1→4)-[β-d-glucopyranosyl-(1→3)]-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosyl ester (1) and 3- O-[β-d-glucopyranosyl-(1→2) -[ β-d-fucopyranosyl-(1→6)]-β-d-glucopyranosyl]-21-O-[(2E,6S)-2,6-dimethyl-6-O-(β-D-quinovopyranosyl) octa-2,7-dienoyl]acacic acid 28-O-α-l-arabinofuranosyl-(1→4)-[β-d-glucopyranosyl-(1→3)]-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosyl ester (2)...
February 19, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29457747/lebbeckoside-c-a-new-triterpenoid-saponin-from-the-stem-barks-of-albizia-lebbeck-inhibits-the-growth-of-human-glioblastoma-cells
#14
Olivier Placide Noté, Joséphine Ngo Mbing, Marie-Claude Kilhoffer, Dieudonné Emmanuel Pegnyemb, Annelise Lobstein
One new acacic acid-type saponin, named lebbeckoside C (1), was isolated from the stem barks of Albizia lebbeck. Its structure was established on the basis of extensive analysis of 1D and 2D NMR (1 H,13 C NMR, DEPT, COSY, TOCSY, ROESY, HSQC and HMBC) experiments, HRESIMS studies, and by chemical evidence as 3-O-[β-d-xylopyranosyl-(l→2)-β-d-fucopyranosyl-(1→6)-[β-d-glucopyranosyl(1→2)]-β-d-glucopyranosyl]-21-O-{(2E,6S)-6-O-{4-O-[(2E,6S)-2,6-dimethyl-6-O-(β-d-quinovopyranosyl)octa-2,7-dienoyl]-4-O-[(2E,6S)-2,6-dimethyl-6-O-(β-d-quinovopyranosyl)octa-2,7-dienoyl]-β-d-quinovopyranosyl}-2,6-dimethylocta-2,7-dienoyl}acacic acid 28 O-[β-d-quinovopyranosyl-(l→3)-[α-l-arabinofuranosyl-(l→4)]-α-l-rhamnopyranosyl-(l→2)-β-d-glucopyranosyl] ester...
February 19, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29457745/evaluation-of-mosquito-larvicidal-activity-of-fruit-extracts-of-acacia-auriculiformis-against-the-japanese-encephalitis-vector-culex-vishnui
#15
Mousumi Barik, Anjali Rawani, Subrata Laskar, Goutam Chandra
The larvicidal potentiality of crude and ethyl acetate extracts of fruits of Acacia auriculiformis was investigated against all the larval instars of JE vector Culex vishnui. The crude extracts showed good results against all the larval instars with highest mortality at 0.09%. Highest mortality was found at 300 ppm of ethyl acetate extract. Lowest LC50 value was obtained at 72 h for third instar larvae. Non target organisms tested, showed no to very less mortality to ethyl acetate solvent extract. Presence of N-H stretching, a C=O stretching, C=C and C-N stretching vibrations of secondary amide or amine group were confirmed from IR analysis...
February 19, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29457602/examination-of-previously-published-data-to-identify-patterns-in-the-social-representation-of-loud-music-in-young-adults-across-countries
#16
Vinaya Manchaiah, Fei Zhao, Susan Oladeji, Pierre Ratinaud
Purpose: The current study was aimed at understanding the patterns in the social representation of loud music reported by young adults in different countries. Materials and Methods: The study included a sample of 534 young adults (18-25 years) from India, Iran, Portugal, United Kingdom, and United States. Participants were recruited using a convince sampling, and data were collected using the free association task. Participants were asked to provide up to five words or phrases that come to mind when thinking about "loud music...
January 2018: Noise & Health
https://www.readbyqxmd.com/read/29457588/tio2-nanotubes-with-different-spacing-fe2o3-decoration-and-their-evaluation-for-li-ion-battery-application
#17
Selda Ozkan, Gihoon Cha, Anca Mazare, Patrik Schmuki
In present work, we report on the use of organized TiO2 nanotube layers with a regular intertube spacing for the growth of highly defined α-Fe2O3 nano-needles in the interspace. These α-Fe2O3 decorated TiO2 NTs are then explored for Li-ion battery applications and compared to classic close-packed NTs that are both decorated with various amounts of nanoscale α-Fe2O3. We show that nanotubes with tube-to-tube spacing allow a uniform decoration of individual nanotubes with regular arrangements of hematite nano-needles...
February 19, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29457519/polygonatone-h-a-new-homoisoflavanone-with-cytotoxicity-from-polygonatum-cyrtonema-hua
#18
Wenxiang Wang, Xilatu Dabu, Juan He, Huixiang Yang, Shengchao Yang, Junwen Chen, Wei Fan, Guanghui Zhang, Jinlong Cai, Honglian Ai, Meirong Hai
A new homoisoflavonoid, (3R)-5,7-dihydroxy-6-methyl-3-(2'-hydroxy-4'-methoxybenzyl)-chroman-4-one (1), namely polygonatone H, in addition to fourteen known homoisoflavones (2-15) were isolated from the rhizome of Polygonatum Cyrtonema Hua. The structures were identified with the aid of 1D/2D NMR spectroscopic technologies. Compounds 2, 6, 8, 10, 11, 13, and 15 were isolated from P. Cyrtonema for the first time. Compound 1 showed cytotoxicities to human cancer cell lines with IC50 values to comparable those of cisplatin...
February 19, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29457506/new-alkylamide-from-the-stems-of-zanthoxylum-nitidum
#19
Suda Chakthong, Rangsima Ampaprom, Sakawduen Inparn, Uraiwan Phetkul, Sasitorn Chusri, Surasak Limsuwan, Supayang Piyawan Voravuthikunchai
A new alkylamide, named (2E,6E,8E)-N-(2-methylpropyl)-10-oxo-2,6,8-decatrienamide (1), together with 22 known compounds (2-23), were isolated from the stems of Zanthoxylum nitidum. Their structures were elucidated by spectroscopic methods, including 1D and 2D NMR spectroscopy. The isolated compounds exhibited slightly antioxidant activities through DPPH and ABTS radical scavenging assays but showed no antibacterial activity against Streptococcus mutans ATCC2517, a dental caries causing bacteria.
February 19, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29457465/further-evaluation-of-a-practitioner-model-for-increasing-eye-contact-in-children-with-autism
#20
John T Rapp, Jennifer L Cook, Raluca Nuta, Carissa Balagot, Kayla Crouchman, Claire Jenkins, Sidrah Karim, Chelsea Watters-Wybrow
Cook et al. recently described a progressive model for teaching children with autism spectrum disorder (ASD) to provide eye contact with an instructor following a name call. The model included the following phases: contingent praise only, contingent edibles plus praise, stimulus prompts plus contingent edibles and praise, contingent video and praise, schedule thinning, generalization assessments, and maintenance evaluations. In the present study, we evaluated the extent to which modifications to the model were needed to train 15 children with ASD to engage in eye contact...
February 1, 2018: Behavior Modification
keyword
keyword
4197
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"