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https://www.readbyqxmd.com/read/29667938/suggested-design-of-gold-nanoobjects-based-terahertz-radiation-source-for-biomedical-research
#1
Andrei Postnikov, Kamil Moldosanov
Gold nanoparticles (GNPs) may serve as "devices" to emit electromagnetic radiation in the terahertz (THz) range, whereby the energy is delivered by radio frequency or microwave photons which won't by themselves induce transitions between sparse confinement-shaped electron levels of a GNP, but may borrow the energy from longitudinal acoustic phonons to overcome the confinement gap. Upon excitation, the Fermi electron cannot relax otherwise than via emitting a THz photon, the other relaxation channels being blocked by force of shape and size considerations...
April 18, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29667772/tead4-exerts-pro-metastatic-effects-and-is-negatively-regulated-by-mir6839-3p-in-lung-adenocarcinoma-progression
#2
Qun Zhang, Hang Fan, Qian Zou, Hongda Liu, Bing Wan, Suhua Zhu, Yangbo Hu, Huijuan Li, ChenXi Zhang, Li Zhou, Qingqing Zhu, Kunhong Xiao, Jianya Zhang, Ping Zhan, Tangfeng Lv, Yong Song
Several studies have shown the tumorigenesis role of transcriptional enhancer associate domain (TEAD) proteins; here, we initially explored expression, function and signalling mechanisms of TEAD4 in lung adenocarcinoma (LAD). Both the mRNA and protein levels of TEAD4 were increased in LAD tissues than those in adjacent nontumourous tissues. Besides, database search indicated a poorer clinical outcome in LAD patients with higher TEAD4 expression, revealing its potential tumour-promoting role. Therefore, we conducted cellular experiments to further investigate its effect on tumour phenotypes...
April 18, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29667706/preliteracy-impairments-in-children-with-neurofibromatosis-type-1
#3
Shelley S Arnold, Jonathan M Payne, Jennifer Lorenzo, Kathryn N North, Belinda Barton
AIM: This cross-sectional study aimed to examine the preliteracy abilities of young children with neurofibromatosis type 1 (NF1) and to identify which of these abilities best predicted conventional literacy (spelling). METHOD: Forty-two children with NF1 (23 males, 19 females; mean age [SD] 5y 6mo [6mo]) were compared with 32 unaffected children (15 males, 17 females; mean age [SD] 5y 4mo [6mo]). All children completed a comprehensive cognitive assessment including measures of phonological processing (phonological awareness, phonological memory, rapid automatic naming) and letter-sound knowledge...
April 18, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29667684/interaction-of-na-k-mg-2-and-ca-2-counter-cations-with-rna
#4
REVIEW
Stefan K Kolev, Petko St Petkov, Miroslav A Rangelov, Dimitar V Trifonov, Teodor I Milenov, Georgi N Vayssilov
Alkaline and alkaline earth ions, namely Na+, K+, Mg2+ and Ca2+, are critical for the stability, proper folding and functioning of RNA. Moreover, those metal ions help to facilitate macromolecular interactions as well as the formation of supramolecular structures (e.g. the ribosome and the ribozymes). Therefore, identifying the interactions between ions and nucleic acids is a key to the better comprehension of the physical nature and biological functions of those biomolecules. The scope of this review is to highlight the preferential location and binding sites of alkaline and alkaline earth metal ions compensating the negatively charged backbone of nucleic acids and interacting with other electronegative centers, focusing on RNA...
April 18, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29667656/carbon-based-hybrid-nanogels-a-synergistic-nanoplatform-for-combined-biosensing-bioimaging-and-responsive-drug-delivery
#5
REVIEW
Hui Wang, Qianwang Chen, Shuiqin Zhou
Nanosized crosslinked polymer networks, named as nanogels, are playing an increasingly important role in a diverse range of applications by virtue of their porous structures, large surface area, good biocompatibility and responsiveness to internal and/or external chemico-physical stimuli. Recently, a variety of carbon nanomaterials, such as carbon quantum dots, graphene/graphene oxide nanosheets, fullerenes, carbon nanotubes, and nanodiamonds, have been embedded into responsive polymer nanogels, in order to integrate the unique electro-optical properties of carbon nanomaterials with the merits of nanogels into a single hybrid nanogel system for improvement of their applications in nanomedicine...
April 18, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29667545/molecular-bases-of-sperm-thermotaxis-old-and-new-knowledges
#6
Luca De Toni, Savina Dipresa, Carlo Foresta, Andrea Garolla
Sperm thermotaxis, namely the temperature-oriented motility of sperm cells, is a key process involved in ejaculated sperm guidance towards the oocyte for fertilization pourposes. Since its discovery in 2003, many studies clarified the dynamic, the sensitivity and the overall weight of this process in the comprehensive context of fertilization. However, the identification of sperm thermosensor/s remained elusive until recently. The most recent cues about the molecular bases of the old known process of thermotaxis are here revised...
April 18, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29667524/optimization-of-the-extraction-of-bioactive-molecules-from-lycium-barbarum-fruits-and-evaluation-of-the-antioxidant-activity-a-combined-study
#7
Chiara Povolo, Alberto Foschini, Giovanni Ribaudo
Novel food, super food, wolfberry, the Himalayan longevity fruit. Several different and, even more, colourful names define the fruits of Lycium barbarum L., one of the most popular food supplements and anti-aging remedies of the recent years. Goji derivatives find application at the interface between food and medicine thanks to the claimed antioxidant and immunomodulatory properties. Aiming at identifying the most effective extraction protocol for processing different goji berries samples (fresh and dried, commercial and from an Italian cultivar), combinations of extractive and analytical techniques were attempted...
April 18, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29667302/tunable-magnetism-in-nanoporous-cuni-alloys-by-reversible-voltage-driven-element-selective-redox-processes
#8
Alberto Quintana, Enric Menéndez, Eloy Isarain-Chávez, Jordina Fornell, Pau Solsona, François Fauth, Maria Dolors Baró, Josep Nogués, Eva Pellicer, Jordi Sort
Voltage-driven manipulation of magnetism in electrodeposited 200 nm thick nanoporous single-phase solid solution Cu20 Ni80 (at%) alloy films (with sub 10 nm pore size) is accomplished by controlled reduction-oxidation (i.e., redox) processes in a protic solvent, namely 1 m NaOH aqueous solution. Owing to the selectivity of the electrochemical processes, the oxidation of the CuNi film mainly occurs on the Cu counterpart of the solid solution, resulting in a Ni-enriched alloy. As a consequence, the magnetic moment at saturation significantly increases (up to 33% enhancement with respect to the as-prepared sample), while only slight changes in coercivity are observed...
April 18, 2018: Small
https://www.readbyqxmd.com/read/29667248/establishment-of-a-radiotelemetric-recording-technique-in-mice-to-investigate-gastric-slow-waves-modulatory-role-of-putative-neurotransmitter-systems
#9
Huichuan Wang, Zengbing Lu, Yuen Hang Liu, Yayi Sun, Longlong Tu, Man P Ngan, Chi-Kong Yeung, John A Rudd
NEW FINDINGS: What is the central question of this study? Gastric slow waves originating from interstitial cells of Cajal-smooth muscle syncytium are usually studied in culture or in tissue segments, but no studies have made recording of slow waves from conscious freely moving mice. Can radiotelemetry be used to record slow waves, and do they respond predictably to drug treatment? What is the main finding and its importance? Radiotelemetry may be used to record slow waves from conscious freely moving mice permitting an examination of drug action in vivo, which is critical to drug discovery projects characterizing drugs and metabolites on gastrointestinal function...
April 18, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29667144/efficacy-and-safety-of-zofenopril-versus-ramipril-in-the-treatment-of-myocardial-infarction-and-heart-failure-a-review-of-the-published-and-unpublished-data-of-the-randomized-double-blind-smile-4-study
#10
REVIEW
Claudio Borghi, Stefano Omboni, Salvatore Novo, Dragos Vinereanu, Giuseppe Ambrosio, Ettore Ambrosioni
Zofenopril is a lipophilic, sulfhydryl group-containing angiotensin-converting enzyme (ACE)-inhibitor, characterized by wide tissue distribution, long duration of action, and pleiotropic effects on endothelial dysfunction. Its clinical efficacy and safety have been described in the four randomized controlled trials of the SMILE program, which globally enrolled more than 3600 patients in post-acute myocardial infarction (AMI) setting. The SMILE-4 study specifically selected patients with left ventricular dysfunction at admission, and compared the effects of zofenopril or ramipril in combination with acetylsalicylic acid (ASA)...
April 17, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29667073/spirituality-experiences-in-hemophilia-patients-a-phenomenological-study
#11
Masoume Rambod, Farkhondeh Sharif, Zahra Molazem, Kate Khair
Spirituality plays an important role in coping with chronic diseases. However, the meaning of spirituality is not known in hemophilia, as a chronic disease. This study aimed to explore the essence of spirituality in hemophilia patients. This qualitative study with a hermeneutic phenomenological approach was conducted on twelve Muslim adult hemophilia patients. The participants were selected using purposeful sampling. The data were gathered through interview. Then, the data were analyzed using thematic analysis and van Manen's methodological framework...
April 17, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29666977/candidate-genes-of-flavonoid-biosynthesis-in-selaginella-bryopteris-l-baker-identified-by-rna-seq
#12
Ravi S Singh, Ravi Kesari, Ujjwal Kumar, Vikash Kumar Jha, Anjani Kumar, Tribhuwan Kumar, Awadhesh K Pal, Prabhash K Singh
In the present study, de novo transcriptome analysis of Selaginella bryopteris in frond and root was performed to understand the regulation of flavonoid (FL) biosynthesis. High-quality data of 5.84 and 5.86 Gb was generated for frond and root, respectively, that assembled into 94,713 and 81,567 transcripts. A total of 87,471 and 73,395 unigenes were obtained from frond and root, respectively. A total of 41,267 and 31,048 CDS of frond and root, respectively, were annotated by BLASTX, which showed maximum hits against S...
April 18, 2018: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/29666975/genomics-that-is-probably-gm-the-impact-a-name-can-have-on-the-interpretation-of-a-technology
#13
Reginald Boersma, Bart Gremmen
We investigate how people form attitudes and make decisions without having extensive knowledge about a technology. We argue that it is impossible for people to carefully study all technologies they encounter and that they are forced to use inferences to make decisions. When people are confronted with an intangible abstract technology, the only visible attribute is the name. This name can determine which inferences a person will use. Considering these inferences is important: first, a name will reach consumers before detailed information, if any, will...
April 17, 2018: Life Sciences, Society and Policy
https://www.readbyqxmd.com/read/29666941/correction-to-a-simple-approach-for-the-preoperative-assessment-of-sacral-morphology-for-percutaneous-si-screw-fixation
#14
Michael Goetzen, Vinzent Kevin Ortner, Richard A Lindtner, Rene Schmid, Michael Blauth, Dietmar Krappinger
In the original article, co-author's given name has been published incorrectly. The correct given name should be Vinzent Kevin.
April 17, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29666892/using-liprotides-to-deliver-cholesterol-to-the-plasma-membrane
#15
Henriette S Frislev, Janni Nielsen, Jesper Nylandsted, Daniel Otzen
Cholesterol (chol) is important in all mammalian cells as a modulator of membrane fluidity. However, its low solubility is a challenge for controlled delivery to membranes. Here we introduce a new tool to deliver chol to membranes, namely, liprotides, i.e., protein-lipid complexes composed of a fatty acid core decorated with partially denatured protein. We focus on liprotides prepared by incubating Ca2+ -depleted α-lactalbumin with oleic acid (OA) for 1 h at 20 °C (lip20) or 80 °C (lip80). The binding and membrane delivery properties of liprotides is compared to the widely chol transporter methyl-β-cyclodextrin (mBCD)...
April 17, 2018: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29666792/steady-state-linear-and-non-linear-optical-spectroscopy-of-organic-chromophores-and-bio-macromolecules
#16
REVIEW
Marco Marazzi, Hugo Gattuso, Antonio Monari, Xavier Assfeld
Bio-macromolecules as DNA, lipid membranes and (poly)peptides are essential compounds at the core of biological systems. The development of techniques and methodologies for their characterization is therefore necessary and of utmost interest, even though difficulties can be experienced due to their intrinsic complex nature. Among these methods, spectroscopies, relying on optical properties are especially important to determine their macromolecular structures and behaviors, as well as the possible interactions and reactivity with external dyes-often drugs or pollutants-that can (photo)sensitize the bio-macromolecule leading to eventual chemical modifications, thus damages...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29666752/pathways-of-topological-rank-analysis-potra-a-novel-method-to-detect-pathways-involved-in-hepatocellular-carcinoma
#17
Chaoxing Li, Li Liu, Valentin Dinu
Complex diseases such as cancer are usually the result of a combination of environmental factors and one or several biological pathways consisting of sets of genes. Each biological pathway exerts its function by delivering signaling through the gene network. Theoretically, a pathway is supposed to have a robust topological structure under normal physiological conditions. However, the pathway's topological structure could be altered under some pathological condition. It is well known that a normal biological network includes a small number of well-connected hub nodes and a large number of nodes that are non-hubs...
2018: PeerJ
https://www.readbyqxmd.com/read/29666599/chronic-stereotype-threat-is-associated-with-mathematical-achievement-on-representative-sample-of-secondary-schoolgirls-the-role-of-gender-identification-working-memory-and-intellectual-helplessness
#18
Sylwia Bedyńska, Izabela Krejtz, Grzegorz Sedek
Stereotype threat affects performance in many different groups across many different domains. Despite a large body of experimental research on situational stereotype threat, little attention has been paid to the consequences of repeated experience of stereotype threat. Using structural equation modeling on data from a representative sample of girls from secondary schools, the current research examined the relations of chronic stereotype threat with mathematical achievement, and effectiveness of working memory functions...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29666597/a-computational-model-of-working-memory-integrating-time-based-decay-and-interference
#19
Benoît Lemaire, Sophie Portrat
There is still a strong debate in the working memory literature about the cause of forgetting, with many articles providing evidence for the existence of temporal decay and as many publications providing evidence compatible with interference being the only mechanism involved in forgetting. In order to reconcile the two views, this article describes TBRS∗ -I (for Time-Based Resource-Sharing∗ -Interference), a computational model of working memory which incorporates an interference-based mechanism to the decay-based implementation TBRS∗ within the TBRS theoretical framework...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29666503/regulatory-t-cell-derived-extracellular-vesicles-modify-dendritic-cell-function
#20
Sim L Tung, Dominic A Boardman, Monica Sen, Marilena Letizia, Qi Peng, Nicole Cianci, Laura Dioni, Leo M Carlin, Robert Lechler, Valentina Bollati, Giovanna Lombardi, Lesley A Smyth
Regulatory T cells (Treg) are a subpopulation of T cells that maintain tolerance to self and limit other immune responses. They achieve this through different mechanisms including the release of extracellular vesicles (EVs) such as exosomes as shown by us, and others. One of the ways that Treg derived EVs inhibit target cells such as effector T cells is via the transfer of miRNA. Another key target for the immunoregulatory function of Tregs is the dendritic cells (DCs). In this study we demonstrate directly, and for the first time, that miRNAs are transferred from Tregs to DCs via Treg derived EVs...
April 17, 2018: Scientific Reports
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