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https://www.readbyqxmd.com/read/28551942/-prostate-cancer-early-detection-using-psa-current-trends-and-recent-updates
#1
REVIEW
Arnon Lavi, Michael Cohen
Prostate cancer (Pca) is the most common malignancy in men and the second cause of death from cancer. The prostate specific antigen (PSA) assay has been used for Pca screening since the beginning of the 1990's and has brought a 40% reduction in mortality. Since Pca is a diverse disease, early detection can lead to overdetection and overtreatment. Pca treatment has significant adverse effects, namely incontinence and erectile dysfunction. How is it then that a simple and inexpensive test that probably caused the most significant reduction in mortality from cancer ever, is regarded to be "not recommended" by some health organizations? Why did the use of PSA testing fall drastically in the US in the last couple of years, while, at the same time, the tendency for diagnosis of higher risk diseases is noticed through large controlled studies, showing the efficacy of PSA testing in mortality reduction? Will PSA serve as a milestone for early detection and mass population screening in general? This review will deal with aspects of PSA screening and will bring the latest updates and dilemmas concerning this evolving topic...
March 2017: Harefuah
https://www.readbyqxmd.com/read/28551873/achromobacter-panacis-sp-nov-isolated-from-rhizosphere-of-panax-ginseng
#2
Priyanka Singh, Yeon Ju Kim, Hina Singh, Mohamed El-Agamy Farh, Deok-Chun Yang
A novel strain DCY105(T) was isolated from soil collected from the rhizosphere of ginseng (Panax ginseng), in Gochang, Republic of Korea. Strain DCY105(T) is Gram-reaction-negative, white, non-motile, non-flagellate, rod-shaped and aerobic. The bacteria grow optimally at 30°C, pH 6.5-7.0 and in the absence of NaCl. Phylogenetically, strain DCY105(T) is most closely related to Achromobacter marplatensis LMG 26219(T) (96.81%). The DNA G+C content of strain DCY105(T) was 64.4 mol%. Ubiquinone 8 was the major respiratory quinone, and phosphatidylethanolamine, phosphatidylglycerol, and diphosphatidylglycerol were amongst the major polar lipids...
June 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28551787/mechanistic-role-of-mptp-in-ischemia-reperfusion-injury
#3
Giampaolo Morciano, Massimo Bonora, Gianluca Campo, Giorgio Aquila, Paola Rizzo, Carlotta Giorgi, Mariusz R Wieckowski, Paolo Pinton
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. The treatment of choice for reducing ischemic injury and limiting infarct size (IS) in patients with ST-segment elevation MI (STEMI) is timely and effective myocardial reperfusion via primary percutaneous coronary intervention (PCI). However, myocardial reperfusion itself may induce further cardiomyocyte death, a phenomenon known as reperfusion injury (RI). The opening of a large pore in the mitochondrial membrane, namely, the mitochondrial permeability transition pore (mPTP), is widely recognized as the final step of RI and is responsible for mitochondrial and cardiomyocyte death...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551785/mitochondria-in-ischemic-heart-disease
#4
L Maximilian Buja
A core feature of ischemic heart disease is injury to cardiomyocytes (CMC). Ischemic CMC manifest the molecular mechanisms to undergo the major forms of cell injury and death, namely, oncotic necrosis, necroptosis, apoptosis and unregulated autophagy. Important modulators of ischemic injury are reperfusion and conditioning. Mitochondria have a major role in mediating the injury to CMC through membrane protein complexes referred to as death channels. Apoptosis is mediated by activation of a channel regulated by the Bcl-2 protein family leading to mitochondrial outer membrane permeabilization (MOMP)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551777/large-scale-functional-neural-network-correlates-of-response-inhibition-an-fmri-meta-analysis
#5
Ruibin Zhang, Xiujuan Geng, Tatia M C Lee
An influential hypothesis from the last decade proposed that regions within the right inferior frontal cortex of the human brain were dedicated to supporting response inhibition. There is growing evidence, however, to support an alternative model, which proposes that neural areas associated with specific inhibitory control tasks co-exist as common network mechanisms, supporting diverse cognitive processes. This meta-analysis of 225 studies comprising 323 experiments examined the common and distinct neural correlates of cognitive processes for response inhibition, namely interference resolution, action withholding, and action cancellation...
May 27, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28551767/does-rarity-mean-imparity-biological-characteristics-of-osteosarcoma-cells-originating-from-the-spine
#6
Zhenhua Zhou, Yan Li, Xu Yan, Xudong Wang, Cheng Yang, Haifeng Wei, Xinghai Yang, Jianru Xiao
PURPOSE: Osteosarcoma is one of the most common malignancies in bones and is often found in limbs. Until now, it is not clear why osteosarcoma is rare in the spine. On the other hand, previous biological characteristics study about osteosarcoma of spine was also rare because of its low incidence. To explore the biology of spinal osteosarcoma, a stable osteosarcoma cell line derived from spine is necessary. METHODS: A novel osteosarcoma cell line named NEO217 was established from spinal osteosarcoma tissues obtained from a Chinese male patient...
May 27, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28551743/effects-of-deltamethrin-on-striatum-and-hippocampus-mitochondrial-integrity-and-the-protective-role-of-quercetin-in-rats
#7
Salim Gasmi, Rachid Rouabhi, Mohamed Kebieche, Samira Boussekine, Aya Salmi, Nadjiba Toualbia, Chahinez Taib, Zina Bouteraa, Hajer Chenikher, Sara Henine, Belgacem Djabri
The present work is to evaluate the neurotoxicity induced by pyrethroid insecticide "Deltamethrin" at 0.32 mg/kg/day in two main regions of the Wistar rat brain (hippocampus and striatum) and the protective effects of Quercetin at 10 mg/kg/day on this toxicity after 90 days of exposure. The assay of brain parameters showed that Deltamethrin caused a significant increase of mitochondrial metabolite level (proteins, lipids, and carbohydrates) and enzyme activity (glutathione S-transferase and superoxide dismutase); a decreased amount of mitochondrial glutathione level and catalase and glutathione peroxidase activities; and an increase of malondialdehyde (MDA) acid levels of the two regions...
May 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28551732/bradyrhizobium-brasilense-sp-nov-a-symbiotic-nitrogen-fixing-bacterium-isolated-from-brazilian-tropical-soils
#8
Elaine Martins da Costa, Amanda Azarias Guimarães, Rayssa Pereira Vicentin, Paula Rose de Almeida Ribeiro, Aniele Carolina Ribas Leão, Eduardo Balsanelli, Liesbeth Lebbe, Maarten Aerts, Anne Willems, Fatima Maria de Souza Moreira
Four strains of rhizobia isolated from nodules of Vigna unguiculata (UFLA03-321(T), UFLA03-320 and UFLA03-290) and Macroptilium atropurpureum (UFLA04-0212) in Brazilian soils were previously reported as a new group within the genus Bradyrhizobium. To determine their taxonomic position, these strains were characterized in this study using a polyphasic approach. The analysis of the 16S rRNA gene grouped the four strains with Bradyrhizobium pachyrhizi PAC48(T). However, the concatenated sequence analysis of the two (recA and glnII) or three (atpD, gyrB and recA) housekeeping genes indicated that these strains represent a novel species of Bradyrhizobium, which is very closely related to B...
May 27, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28551727/introduction-of-therapeutic-reference-pricing-in-slovenia-and-its-economic-consequences
#9
Nika Marđetko, Mitja Kos
OBJECTIVES: To evaluate the economic outcomes that arose from the introduction of therapeutic reference pricing (TRP) into Slovenian practice in 2013, based on the first three therapeutic classes, namely proton-pump inhibitors (PPIs), angiotensin-converting-enzyme inhibitors (ACEIs), and lipid-lowering agents (LLAs). METHODS: National health claims data on prescription medicines from January 2011 to December 2015 were analyzed. Monthly medicine expenditure, medicine consumption, changes in medicine use, and market competition (Herfindahl-Hirschman index) were determined to assess the TRP impact on market dynamics...
May 27, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28551711/why-are-most-phospholipidosis-inducers-also-herg-blockers
#10
Svetoslav Slavov, Iva Stoyanova-Slavova, Shuaizhang Li, Jinghua Zhao, Ruili Huang, Menghang Xia, Richard Beger
Recent reports have noted that a number of compounds that block the human Ether-à-go-go related gene (hERG) ion channel also induce phospholipidosis (PLD). To explore a hypothesis explaining why most PLD inducers are also hERG inhibitors, a modeling approach was undertaken with data sets comprised of 4096 compounds assayed for hERG inhibition and 5490 compounds assayed for PLD induction. To eliminate the chemical domain effect, a filtered data set of 567 compounds tested in quantitative high-throughput screening (qHTS) format for both hERG inhibition and PLD induction was constructed...
May 27, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28551517/binding-sno2-nanoparticles-onto-carbon-nanotubes-with-assistance-of-amorphous-moo3-towards-enhanced-lithium-storage-performance
#11
Daxian Cao, Hangyu Gu, Chong Xie, Beibei Li, Hongkang Wang, Chunming Niu
We report the synthesis of a novel SnO2/MoO3/carbon nanotubes (CNTs) hybrid (denote as SMC) via hydrothermally treating aqueous SnCl4-Na2MoO4-CNTs suspension. The hydrolysis of SnCl4 promotes the precipitation of Na2MoO4, resulting in the simultaneous coprecipitation of the amorphous MoO3 and SnO2 nanoparticles which attach onto the CNTs (Note that no MoOx is produced in the absence of SnCl4). When used as anode materials for lithium ion batteries (LIBs), the as-prepared SMC hybrid delivers a high reversible capacities of 1032 and 887mAh/g after 50 cycles at current densities of 200 and 500mA/g, respectively, and still retains a reversible capacity of 496mAh/g even after 200 cycles at a higher rate of 2A/g, which shows much better lithium storage performance than that of the counterpart hybrid of SnO2/CNTs (denote as SC, with only 569mAh/g after 50 cycles at 200mA/g)...
May 20, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28551502/promiscuity-and-selectivity-of-small-molecule-inhibitors-across-tam-receptor-tyrosine-kinases-in-pediatric-leukemia
#12
Mao-Hua Liu, Shi-Bing Chen, Juan Yu, Cheng-Jun Liu, Xiao-Jing Zhang
The TAM receptor tyrosine kinase family member Mer has been recognized as an attractive therapeutic target for pediatric leukemia. Beside Mer the family contains other two kinases, namely, Tyro3 and Axl, which are highly homologues with Mer and thus most existing small-molecule inhibitors show moderate or high promiscuity across the three kinases. Here, the structural basis and energetic property of selective binding of small-molecule inhibitors to the three kinases were investigated at molecular level. It is found that the selectivity is primarily determined by the size, shape and configuration of kinase's ATP-binding site; the Mer and Axl possess a small, closed active pocket as compared to the bulky, open pocket of Tyro3...
May 15, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28551421/interaction-of-gliding-motion-of-bacteria-with-rheological-properties-of-the-slime
#13
Z Asghar, N Ali, M Sajid
Bacteria which do not have organelles of motility, such as flagella, adopt gliding as a mode of locomotion. In gliding motility bacterium moves under its own power by secreting a layer of slime on the substrate. The exact mechanism by which a glider achieves motility is yet in controversy but there are evidences which support the wave-like undulation on the surface of the organism, as a possible mechanism of motility. Based on this observation, a model of undulating sheet over a layer of slime is examined as a possible model of the gliding motion of a bacterium...
May 24, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28551403/chaperone-like-activity-of-synthetic-polyanions-can-be-higher-than-the-activity-of-natural-chaperones-at-elevated-temperature
#14
Pavel I Semenyuk, Lidia P Kurochkina, Nikolai B Gusev, Vladimir A Izumrudov, Vladimir I Muronetz
Polyelectrolytes are a prospective tool for protection of proteins against aggregation. We compared synthetic polyanion, poly(styrene sulfonate), and natural chaperones of different types, namely, GroEL-like chaperonin from Pseudomonas aeruginosa phage EL and human small heat shock protein HspB5 (αB-crystallin), in their ability to prevent aggregation of client proteins. At 45 °C, all three agents efficiently suppressed thermal aggregation of phage endolysin. At higher temperatures, HspB5 and poly(styrene sulfonate) also inhibited endolysin aggregation, though polyanion became less efficient than HspB5 at 55 °C and 60 °C...
May 24, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28551383/a-exceptional-collision-tumor-of-primary-adrenal-angiosarcoma-and-non-functioning-adrenocortical-adenoma
#15
Katsumi Takizawa, Kenichi Kohashi, Takahito Negishi, Kenichi Taguchi, Yuichi Yamada, Motonobu Nakamura, Yoshinao Oda
Primary adrenal angiosarcoma is an extremely rare vascular tumor. We report a case of a 63-year-old man with a collision tumor of epithelioid angiosarcoma and adrenocortical adenoma of the right adrenal gland. The adrenal tumor was incidentally observed by a preoperative computed tomography (CT) scan of penis squamous cell carcinoma. The patient underwent a right laparoscopic adrenalectomy, and the tumor size measured 34×34×15mm. Histological examination revealed two different tumor cell proliferations, namely epithelioid angiosarcoma and adrenocortical adenoma...
April 19, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28551311/evaluation-of-pharmacokinetics-and-blood-brain-barrier-permeability-of-mitragynine-using-in-vivo-microdialysis-technique
#16
Wai Mun Kong, Zahurin Mohamed, Mohammed A Alshawsh, Zamri Chik
A microdialysis system coupled with a sensitive ultra-fast liquid chromatography-mass spectrometry (UFLC-MS) method was developed for the pharmacokinetic analysis of mitragynine in rat blood and striatum. Mitragynine is an active alkaloid of Mitragyna speciosa and has been proposed to be used for opioid withdrawal therapy. In this study, chromatographic separation was performed in a gradient elution mode with 0.1% formic acid and acetonitrile on a Zorbax Eclipse C18 column. The mass spectrometric (MS) analysis was carried out in a positive electrospray mode and mitragynine ion (m/z 399...
May 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28551270/inorganic-arsenic-removal-in-rice-bran-by-percolating-cooking-water
#17
Antonio J Signes-Pastor, Manus Carey, Andrew A Meharg
Rice bran, a by-product of milling rice, is highly nutritious but contains very high levels of the non-threshold carcinogen inorganic arsenic (i-As), at concentrations around 1mg/kg. This i-As content needs to be reduced to make rice bran a useful food ingredient. Evaluated here is a novel approach to minimizing rice bran i-As content which is also suitable for its stabilization namely, cooking bran in percolating arsenic-free boiling water. Up to 96% of i-As removal was observed for a range of rice bran products, with i-As removal related to the volume of cooking water used...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28551215/effect-of-different-drying-techniques-on-bioactive-components-fatty-acid-composition-and-volatile-profile-of-robusta-coffee-beans
#18
Wenjiang Dong, Rongsuo Hu, Zhong Chu, Jianping Zhao, Lehe Tan
This study investigated the effect of different drying techniques, namely, room-temperature drying (RTD), solar drying (SD), heat-pump drying (HPD), hot-air drying (HAD), and freeze drying (FD), on bioactive components, fatty acid composition, and the volatile compound profile of robusta coffee beans. The data showed that FD was an effective method to preserve fat, organic acids, and monounsaturated fatty acids. In contrast, HAD was ideal for retaining polyunsaturated fatty acids and amino acids. Sixty-two volatile compounds were identified in the differently dried coffee beans, representing 90% of the volatile compounds...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28551149/advanced-predictive-methods-for-wine-age-prediction-part-i-a-comparison-study-of-single-block-regression-approaches-based-on-variable-selection-penalized-regression-latent-variables-and-tree-based-ensemble-methods
#19
Ricardo Rendall, Ana Cristina Pereira, Marco S Reis
In this paper we test and compare advanced predictive approaches for estimating wine age in the context of the production of a high quality fortified wine - Madeira Wine. We consider four different data sets, namely, volatile, polyphenols, organic acids and the UV-vis spectra. Each one of these data sets contain chemical information of a different nature and present diverse data structures, namely a different dimensionality, level of collinearity and degree of sparsity. These different aspects may imply the use of different modelling approaches in order to better explore the data set's information content, namely their predictive potential for wine age...
August 15, 2017: Talanta
https://www.readbyqxmd.com/read/28551119/advanced-predictive-methods-for-wine-age-prediction-part-ii-a-comparison-study-of-multiblock-regression-approaches
#20
Maria P Campos, Ricardo Sousa, Ana C Pereira, Marco S Reis
In this article, we extend the scope of the first paper of the sequel, which was dedicated to the analysis of advanced single-block regression methods (Rendall et al., 2016) [1], to the class of multiblock regression approaches. The datasets contemplated for developing the multiblock approaches are the same as in the former publication: volatile, polyphenols, organic acids composition and the UV-Vis spectra. The context is still the prediction of the ageing time of one of finest Portuguese fortified wines, the Madeira Wine, but now the data collected from the different analytical sources is explored simultaneously, in a more structured and informative way, through multiblock methodologies...
August 15, 2017: Talanta
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