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https://www.readbyqxmd.com/read/28769078/assessment-of-a-novel-bile-solubility-test-and-maldi-tof-for-the-differentiation-of-streptococcus-pneumoniae-from-other-mitis-group-streptococci
#1
Hans-Christian Slotved, Richard R Facklam, Kurt Fuursted
This study assesses a novel bile solubility test and MALDI-TOF for the differentiation of Streptococcus pneumoniae from other mitis group streptococci, including differentiation of S. pneumoniae from Streptococcus pseudopneumoniae. Eighty-four species verified mitis group isolates were subjected to our bile solubility test (which measures and calculates the differences of absorbance in the test tube containing 10% sodium deoxycholate versus a blank control tube, after incubation for 10 minutes at 36 °C using a spectrophotometer) and MALDI-TOF MS (both the standard result output and by visual spectra evaluation)...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729954/clinical-streptococcal-isolates-distinct-from-streptococcus-pneumoniae-but-containing-the-%C3%AE-glucosyltransferase-tts-gene-and-expressing-serotype-37-capsular-polysaccharide
#2
Carmen L Sheppard, Georgia Kapatai, Karen Broughton, Ulf Schaefer, Matthew Hannah, David J Litt, Norman K Fry
The major virulence factor of the pneumococcus, and target for conjugate vaccines, is the polysaccharide capsule, which is usually encoded by the highly variable cps locus. Serotype 37 is an unusual pneumococcal type in which the single β-glucosyltransferase gene responsible for serotype capsule production (tts) is located outside of the capsular operon region. Using a previously described automated whole genome sequence (WGS)-based serotyping bioinformatics tool, PneumoCaT, we identified and investigated seven clinical isolates (three from blood cultures) of non-pneumococcal streptococci containing a highly homologous tts and included them in a study panel of 20 isolates which included a 11 further clinical isolates of S...
2017: PeerJ
https://www.readbyqxmd.com/read/28596991/long-persistence-of-a-streptococcus-pneumoniae-23f-clone-in-a-cystic-fibrosis-patient
#3
Martin Rieger, Harald Mauch, Regine Hakenbeck
Streptococcus pneumoniae isolates of serotype 23F with intermediate penicillin resistance were recovered on seven occasions over a period of 37 months from a cystic fibrosis patient in Berlin. All isolates expressed the same multilocus sequence type (ST), ST10523. The genome sequences of the first and last isolates, D122 and D141, revealed the absence of two phage-related gene clusters compared to the genome of another ST10523 strain, D219, isolated earlier at a different place in Germany. Genomes of all three strains carried the same novel mosaic penicillin-binding protein (PBP) genes, pbp2x, pbp2b, and pbp1a; these genes were distinct from those of other penicillin-resistant S...
May 2017: MSphere
https://www.readbyqxmd.com/read/28487677/accurate-differentiation-of-streptococcus-pneumoniae-from-other-species-within-the-streptococcus-mitis-group-by-peak-analysis-using-maldi-tof-ms
#4
Mercedes Marín, Emilia Cercenado, Carlos Sánchez-Carrillo, Adrián Ruiz, Álvaro Gómez González, Belén Rodríguez-Sánchez, Emilio Bouza
Despite the benefits of MALDI-TOF MS technology (Matrix-Assisted Laser Desorption-Ionization Time-Of-Flight Mass Spectrometry) reported worldwide and the continuous improving of the available databases, discrimination between Streptococcus pneumoniae and closely related species within the Streptococcus mitis group (SMG) using this methodology has been suboptimal. However, the accurate identification at the species level of this group of microorganisms is important for the appropriate management of infected patients...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28486933/influence-of-chronic-azithromycin-treatment-on-the-composition-of-the-oropharyngeal-microbial-community-in-patients-with-severe-asthma
#5
Guido Lopes Dos Santos Santiago, Guy Brusselle, Kenny Dauwe, Pieter Deschaght, Chris Verhofstede, Dries Vaneechoutte, Ellen Deschepper, Paul Jordens, Guy Joos, Mario Vaneechoutte
BACKGROUND: This study of the oropharyngeal microbiome complements the previously published AZIthromycin in Severe ASThma (AZISAST) clinical trial, where the use of azithromycin was assessed in subjects with exacerbation-prone severe asthma. Here, we determined the composition of the oropharyngeal microbial community by means of deep sequencing of the amplified 16S rRNA gene in oropharyngeal swabs from patients with exacerbation-prone severe asthma, at baseline and during and after 6 months treatment with azithromycin or placebo...
May 10, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28483958/new-aspects-of-the-interplay-between-penicillin-binding-proteins-murm-and-the-two-component-system-ciarh-of-penicillin-resistant-streptococcus-pneumoniae-serotype-19a-isolates-from-hungary
#6
Inga Schweizer, Sebastian Blättner, Patrick Maurer, Katharina Peters, Daniela Vollmer, Waldemar Vollmer, Regine Hakenbeck, Dalia Denapaite
The Streptococcus pneumoniae clone Hungary(19A)-6 expresses unusually high levels of β-lactam resistance, which is in part due to mutations in the MurM gene, encoding a transferase involved in the synthesis of branched peptidoglycan. Moreover, it contains the allele ciaH232, encoding the histidine kinase CiaH (M. Müller, P. Marx, R. Hakenbeck, and R. Brückner, Microbiology 157:3104-3112, 2011, https://doi.org/10.1099/mic.0.053157-0). High-level penicillin resistance primarily requires the presence of low-affinity (mosaic) penicillin binding protein (PBP) genes, as, for example, in strain Hu17, a closely related member of the Hungary(19A)-6 lineage...
July 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28376744/effects-of-pseudomonas-aeruginosa-and-streptococcus-mitis-mixed-infection-on-tlr4-mediated-immune-response-in-acute-pneumonia-mouse-model
#7
Chao Song, Hongdong Li, Yunhui Zhang, Jialin Yu
BACKGROUND: Our previous research on the diversity of microbiota in the endotracheal tubes (ETTs) of neonates in the neonatal intensive care unit found that Pseudomonas aeruginosa (P. aeruginosa) and Streptococcus mitis (S. mitis) were the dominant bacteria on the ETT surface and the existence of S. mitis could promote biofilm formation and pathogenicity of P. aeruginosa. Toll-like receptor 4 (TLR4), which has been widely detected on the surface of airway epithelial cells, is the important component of the innate immune system...
April 4, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28193649/insight-into-the-diversity-of-penicillin-binding-protein-2x-alleles-and-mutations-in-viridans-streptococci
#8
Mark van der Linden, Julia Otten, Carina Bergmann, Cristina Latorre, Josefina Liñares, Regine Hakenbeck
The identification of commensal streptococci species is an everlasting problem due to their ability to genetically transform. A new challenge in this respect is the recent description of Streptococcus pseudopneumoniae as a new species, which was distinguished from closely related pathogenic S. pneumoniae and commensal S. mitis by a variety of physiological and molecular biological tests. Forty-one atypical S. pneumoniae isolates have been collected at the German National Reference Center for Streptococci (GNRCS)...
May 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28135322/naturally-acquired-human-immunity-to-pneumococcus-is-dependent-on-antibody-to-protein-antigens
#9
Robert Wilson, Jonathan M Cohen, Mark Reglinski, Ricardo J Jose, Win Yan Chan, Helina Marshall, Corné de Vogel, Stephen Gordon, David Goldblatt, Fernanda C Petersen, Helen Baxendale, Jeremy S Brown
Naturally acquired immunity against invasive pneumococcal disease (IPD) is thought to be dependent on anti-capsular antibody. However nasopharyngeal colonisation by Streptococcus pneumoniae also induces antibody to protein antigens that could be protective. We have used human intravenous immunoglobulin preparation (IVIG), representing natural IgG responses to S. pneumoniae, to identify the classes of antigens that are functionally relevant for immunity to IPD. IgG in IVIG recognised capsular antigen and multiple S...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28116553/performance-of-the-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-system-for-rapid-identification-of-streptococci-a-review
#10
REVIEW
W-T Fan, T-T Qin, R-R Bi, H-Q Kang, P Ma, B Gu
Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been developed as a new type of soft ionization mass spectrometry in recent years. An increasing number of clinical microbiological laboratories consider it as an innovative approach for bacterial identification. This study was undertaken in order to evaluate the use of MALDI-TOF MS for rapid identification of the clinical streptococci. A systematic review was conducted based on a literature search of the Medline and Embase databases...
January 23, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28096486/phage-derived-protein-induces-increased-platelet-activation-and-is-associated-with-mortality-in-patients-with-invasive-pneumococcal-disease
#11
Rahajeng N Tunjungputri, Fredrick M Mobegi, Amelieke J Cremers, Christa E van der Gaast-de Jongh, Gerben Ferwerda, Jacques F Meis, Nel Roeleveld, Stephen D Bentley, Alexander S Pastura, Sacha A F T van Hijum, Andre J van der Ven, Quirijn de Mast, Aldert Zomer, Marien I de Jonge
To improve our understanding about the severity of invasive pneumococcal disease (IPD), we investigated the association between the genotype of Streptococcus pneumoniae and disease outcomes for 349 bacteremic patients. A pneumococcal genome-wide association study (GWAS) demonstrated a strong correlation between 30-day mortality and the presence of the phage-derived gene pblB, encoding a platelet-binding protein whose effects on platelet activation were previously unknown. Platelets are increasingly recognized as key players of the innate immune system, and in sepsis, excessive platelet activation contributes to microvascular obstruction, tissue hypoperfusion, and finally multiorgan failure, leading to mortality...
January 17, 2017: MBio
https://www.readbyqxmd.com/read/28068884/evaluation-of-protein-spectra-cluster-analysis-for-streptococcus-spp-identification-from-various-swine-clinical-samples
#12
Carlos E C Matajira, Luisa Z Moreno, Vasco T M Gomes, Ana Paula S Silva, Renan E Mesquita, Daniela S Doto, Franco F Calderaro, Fernando N de Souza, Ana Paula G Christ, Maria Inês Z Sato, Andrea M Moreno
Traditional microbiological methods enable genus-level identification of Streptococcus spp. isolates. However, as the species of this genus show broad phenotypic variation, species-level identification or even differentiation within the genus is difficult. Herein we report the evaluation of protein spectra cluster analysis for the identification of Streptococcus species associated with disease in swine by means of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). A total of 250 S...
March 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28053215/improved-differentiation-of-streptococcus-pneumoniae-and-other-s-mitis-group-streptococci-by-maldi-biotyper-using-an-improved-maldi-biotyper-database-content-and-a-novel-result-interpretation-algorithm
#13
Inka Harju, Christoph Lange, Markus Kostrzewa, Thomas Maier, Kaisu Rantakokko-Jalava, Marjo Haanperä
Reliable distinction of Streptococcus pneumoniae and viridans group streptococci is important because of the different pathogenic properties of these organisms. Differentiation between S. pneumoniae and closely related Sreptococcusmitis species group streptococci has always been challenging, even when using such modern methods as 16S rRNA gene sequencing or matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry. In this study, a novel algorithm combined with an enhanced database was evaluated for differentiation between S...
March 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27935839/capsular-polysaccharide-expression-in-commensal-streptococcus-species-genetic-and-antigenic-similarities-to-streptococcus-pneumoniae
#14
Uffe B Skov Sørensen, Kaihu Yao, Yonghong Yang, Hervé Tettelin, Mogens Kilian
Expression of a capsular polysaccharide is considered a hallmark of most invasive species of bacteria, including Streptococcus pneumoniae, in which the capsule is among the principal virulence factors and is the basis for successful vaccines. Consequently, it was previously assumed that capsule production distinguishes S. pneumoniae from closely related commensals of the mitis group streptococci. Based on antigenic and genetic analyses of 187 mitis group streptococci, including 90 recognized serotypes of S...
November 15, 2016: MBio
https://www.readbyqxmd.com/read/27924597/natural-transformation-of-oral-streptococci-by-use-of-synthetic-pheromones
#15
Gabriela Salvadori, Roger Junges, Rabia Khan, Heidi A Åmdal, Donald A Morrison, Fernanda C Petersen
The discovery that Streptococcus pneumoniae uses a competence-stimulating peptide (CSP) to induce competence for natural transformation, and that other species of the mitis and the anginosus streptococcal groups use a similar system, has expanded the tools to explore gene function and regulatory pathways in streptococci. Two other classes of pheromones have been discovered since then, comprising the bacteriocin-inducing peptide class found in Streptococcus mutans (also named CSP, although different from the former) and the SigX-inducing peptides (XIP), in the mutans, salivarius, bovis, and pyogenes groups of streptococci...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27821139/micafungin-versus-caspofungin-in-the-treatment-of-candida-glabrata-infection-a-case-report
#16
COMPARATIVE STUDY
Shoko Merrit Yamada, Yusuke Tomita, Tomotsugu Yamaguchi, Toshiaki Matsuki
BACKGROUND: Micafungin and caspofungin, which are both echinocandins, elicit their antifungal effects by suppressing the synthesis of β-D-glucan, an essential component of fungal cell walls. If micafungin is not effective against a fungal infection, is it unreasonable to switch to caspofungin? CASE PRESENTATION: An 80-year-old Asian man presented to our hospital with brain and lung abscesses. Klebsiella pneumonia and Escherichia coli were identified by sputa culture and Streptococcus mitis was identified in the brain abscess culture obtained by drainage surgery...
November 8, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27781088/ability-of-device-to-collect-bacteria-from-cough-aerosols-generated-by-adults-with-cystic-fibrosis
#17
David N Ku, Sarah K Ku, Beth Helfman, Nael A McCarty, Bernard J Wolff, Jonas M Winchell, Larry J Anderson
Background: Identifying lung pathogens and acute spikes in lung counts remain a challenge in the treatment of patients with cystic fibrosis (CF). Bacteria from the deep lung may be sampled from aerosols produced during coughing. Methods: A new device was used to collect and measure bacteria levels from cough aerosols of patients with CF. Sputum and oral specimens were also collected and measured for comparison. Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Streptococcus mitis were detected in specimens using Real-Time Polymerase Chain Reaction (RT-PCR) molecular assays...
2016: F1000Research
https://www.readbyqxmd.com/read/27534397/re-evaluation-of-the-taxonomy-of-the-mitis-group-of-the-genus-streptococcus-based-on-whole-genome-phylogenetic-analyses-and-proposed-reclassification-of-streptococcus-dentisani-as-streptococcus-oralis-subsp-dentisani-comb-nov-streptococcus-tigurinus-as-streptococcus
#18
Anders Jensen, Christian F P Scholz, Mogens Kilian
The Mitis group of the genus Streptococcus currently comprises 20 species with validly published names, including the pathogen S. pneumoniae. They have been the subject of much taxonomic confusion, due to phenotypic overlap and genetic heterogeneity, which has hampered a full appreciation of their clinical significance. The purpose of this study was to critically re-examine the taxonomy of the Mitis group using 195 publicly available genomes, including designated type strains for phylogenetic analyses based on core genomes, multilocus sequences and 16S rRNA gene sequences, combined with estimates of average nucleotide identity (ANI) and in silico and in vitro analyses of specific phenotypic characteristics...
November 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27516758/pl3-amidase-a-tailor-made-lysin-constructed-by-domain-shu%C3%AF-ing-with-potent-killing-activity-against-pneumococci-and-related-species
#19
Blas Blázquez, Alba Fresco-Taboada, Manuel Iglesias-Bexiga, Margarita Menéndez, Pedro García
The emergence and spread of antibiotic-resistant bacteria is pushing the need of alternative treatments. In this context, phage therapy is already a reality to successfully fight certain multiresistant bacteria. Among different phage gene products, murein hydrolases responsible of phage progeny liberation (also called lysins or endolysins) are weapons that target specific peptidoglycan bonds, leading to lysis and death of susceptible bacteria when added from the outside. In the pneumococcal system, all but one phage murein hydrolases reported to date share a choline-binding domain that recognizes cell walls containing choline residues in the (lipo)teichoic acids...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27460295/bacteremia-due-to-streptococcus-tigurinus-a-case-report-and-literature-review
#20
Jun Hirai, Daisuke Sakanashi, Mao Hagihara, Shusaku Haranaga, Kohei Uechi, Hideo Kato, Hiroyuki Hamada, Naoya Nishiyama, Yusuke Koizumi, Hiroyuki Suematsu, Yuka Yamagishi, Jiro Fujita, Hiroshige Mikamo
Gene sequence analysis methods, including 16S rRNA identification, allows accurate identification of Streptococcus species, which include phenotypically closely related species that are difficult to differentiate using conventional chemical methods. We report a case of bacteremia due to Streptococcus tigurinus, identified by 16S rRNA, in a 72-year-old woman with gastrointestinal cancer and ascites. She was hospitalized to undergo elective tumor-related surgery. Five days prior to undergoing surgery, she developed a fever with no obvious source of infection...
November 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
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