Xia Lin, Mohnad Abdalla, Junjie Yang, Lei Liu, Yali Fu, Yanli Zhang, Shuchun Yang, Han Yu, Yongsheng Ge, Sufang Zhang, Guiyun Kang, Wei Dang, Qin Jiang, Ying Wang, Zhongtao Gai
Sepsis is a life-threatening multiple-organ injury caused by disordered host immune response to microbial infection. However, the correlation between gut microbiota dysbiosis and immune indicators remains unexplored. To address this gap in knowledge, we carried out 16 S rDNA sequencing, analyzed clinical fecal samples from children with sepsis (n = 30) and control children (n = 25), and obtained immune indicators, including T cell subtypes (CD3+ , CD3+ CD4+ , CD3+ CD8+ , and CD4/CD8), NK cells, cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ), and immunoglobulin indices (IgA, IgE, IgM and IgG)...
October 16, 2023: BMC Pediatrics