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Liver tranplantation

Hasmukh J Prajapati, Hyun S Kim
PURPOSE: To develop the treatment algorithm from multivariate survival analyses (MVA) in patients with Barcelona clinic liver cancer (BCLC) C (advanced) Hepatocellular carcinoma (HCC) patients treated with Trans-arterial Chemoembolization (TACE). METHODS: Consecutive unresectable and non-tranplantable patients with advanced HCC, who received DEB TACE were studied. A total of 238 patients (mean age, 62.4yrs) was included in the study. Survivals were analyzed according to different parameters from the time of the 1st DEB TACE...
2017: PloS One
Hans van Goudoever
Paediatric tertiary care is highly centralized in the Netherlands. The country is small (16 million inhabitants, overall unemployment rates were approximately 7 % in 2014, while young adult (< 25 years) unemployment rates were 12 %) with the majority of the population living in Amsterdam and Rotterdam and their neighbouring cities/villages. There are 90 hospitals taking care for children in the Netherlands. Specific types of highly specialized care, such as transplantation, are provided in a maximum of three centres (kidney transplants in 3, bone marrow tranplants in 2, liver transplants in only one center), while neonatal intensive care is offered in 10 hospitals...
2015: Pädiatrie und Pädologie
Maria Paola Serra, Fabio Marongiu, Michela Marongiu, Antonella Contini, Ezio Laconi
BACKGROUND & AIMS: The regenerative potential of the liver declines with age, this might be dependent on a decrease in the intensity of the stimulus and/or an increased refractoriness of the target. In the present study, we compared the in vivo growth capacity of young and old hepatocytes transplanted into the same host. METHODS: We utilized the retrorsine (RS)-based model for liver repopulation, which provides a specific and effective stimulus for transplanted hepatocytes...
June 2015: Journal of Hepatology
Gursimran Kochhar, Jose Mari Parungao, Ibrahim A Hanouneh, Mansour A Parsi
Biliary tract complications are the most common complications after liver transplantation. These complications are encountered more commonly as a result of increased number of liver transplantations and the prolonged survival of transplant patients. Biliary complications remain a major source of morbidity in liver transplant patients, with an incidence of 5%-32%. Post liver transplantation biliary complications include strictures (anastomotic and non-anastomotic), leaks, stones, sphincter of Oddi dysfunction, and recurrence of primary biliary disease such as primary sclerosing cholangitis and primary biliary cirrhosis...
May 21, 2013: World Journal of Gastroenterology: WJG
Sezai Yilmaz, Cuneyt Kayaalp, Cengiz Ara, Mehmet Yilmaz, Burak Isik, Cemalettin Aydin, Dincer Ozgor, Abuzer Dirican, Bora Barut, Bulent Unal, Turgut Piskin, Mustafa Ates, Ramazan Kutlu, Huseyin Ilksen Toprak, Yasar Bayindir, Hale Kirimlioglu, Murat Aladag, Murat Harputluoglu, Ayşe Selimoglu, Hamza Karabiber, Kendal Yalcin, Vedat Kirimlioglu
BACKGROUND/AIMS: Living donor liver transplantations (LDLT) is a definitive treatment for patients with end-stage liver disease (ESLD), especially in the countries with donation problem. Between April 2007 and April 2010, we performed LDLT in 289 patients. Fifteen of the cases required re-transplantations. This study evaluates these 304 consecutive LDLTs donor and recipient outcomes. METHODOLOGY: Complication rates and survival data of the recipients and donors of 304 LDLT cases were analyzed...
July 2013: Hepato-gastroenterology
Zhi-jun Zhu, Li-wei Zhu, Wei Gao, Wen-tao Jiang, Ya-min Zhang, Jian-jun Zhang, Ming-sheng Huai, Tao Yang, Li-ying Sun, Lin Wei, Zhi-gui Zeng, Jun-jie Li, Zhong-yang Shen
OBJECTIVE: To investigate the donor evaluation, surgical protocol, and the complication for the adult-to-adult living donor liver transplantation (AALDLT). METHODS: There were 94 cases of AALDLT were performed by the same surgical team from January 2007 to August 2010. Patients aged from 18 to 74 years. Donors aged from 19 to 60 years. All the 94 cases' operation protocol as following, 2 cases with left lobe liver graft, 92 cases with right lobe graft, 44 cases with middle hepatic vein (MHV) harvested, and 48 cases without MHV...
December 2011: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Milivoje Vuković, Nebojsa Moljević, Zoran Milosević, Nenad Katanić, Dragan Krivokuća
INTRODUCTION: Liver transplantation is the most demanding of all solid organ tranplantations. It requires perfect organization and motivation of health care professionals, patients and their families. This article deals with the procedure for multiple organ procurement, reviews criteria for organ donation and describes the surgical tehnique for multiple organ procurement. DISCUSSION: Adequate selection and evaluation of cadaveric donors and of organs for transplantation should include early identification of potential donors, and early diagnosis of brain death...
July 2007: Medicinski Pregled
Serdar Akça, Inci Süleymanlar, Dinç Dinçer, Alper Demirbaş, Tekinalp Gelen, Alihan Gürkan, Ozlem Elpek, Can Ozkaynak, Fahri Işitan
Hepatic epithelioid hemangiendothelioma is a rare vascular tumor. The clinical course is unpredictable and different treatment modalities are offered depending on the patients condition. Orthotopic liver tranplantation is the choice of treatment in diffuse cases without metastases. A 32 year old woman was admitted to hospital with multiple mass lesions diagnosed by ultrasonography of the liver. Physical examination was normal except for a painless hepatomegaly, and her biochemical tests were within the normal range...
December 2002: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Jia-Hong Dong
No abstract text is available yet for this article.
August 2005: Hepatobiliary & Pancreatic Diseases International: HBPD INT
Behrooz Broumand
Iran is a tropical country with a land area of 1,648,000 square kilometers and a population of 68,100,000. Iran has a recorded history that dates back 2553 years. Its earliest medical school was Pasargad. Jondi Chapour University was founded 1753 years ago during the Sassanid dynasty as a center for higher education in medicine, philosophy, and pharmacology. Indeed, the idea of xenotransplantation dates back to days of Achaemenidae (Achaemenian dynasty), as evidenced by engravings of many mythologic chimeras still present in Persepolis...
June 2005: Experimental and Clinical Transplantation
Sebastian Scholl, Herbert G Sayer, Lars-Olof Mügge, Christoph Kasper, Marko Pietraszczyk, Kay-Oliver Kliche, Joachim H Clement, Klaus Höffken
PURPOSE: Acute graft-versus-host disease (GvHD) is a constant and severe complication after allogeneic stem cell transplantation regularly involving skin, liver, gut, and lungs. The cytokine interleukin-18 (IL-18) has been shown to increase in patients who develop acute GvHD after bone marrow tranplantation (BMT). MATERIALS AND METHODS: Here, we measured IL-18 serum levels after peripheral blood stem cell transplantation (PBSCT) at several characteristic time points in 24 patients (median age 46 years)...
December 2004: Journal of Cancer Research and Clinical Oncology
M Akyildiz, Z Karasu, S Cagirgan, M Kilic, Y Tokat
Rituximab an anti-CD20 chimeric monoclonal antibody directed against the CD20 antigen on B lymphocytes, has been demonstrated to be highly effective for B-cell depletion. Because of its biological properties, it has become as a treatment option for a variety of autoimmune diseases. We report successful treatment of a 25-year-old male cadaveric liver retransplant recipient who displayed severe immune hemolytic anemia with rituximab, despite no previous response to corticosteroids plus intravenous immune globulin therapy...
June 2004: Transplantation Proceedings
S Schwitalla, F Heres, F W Röhl, G Pfau, C Kessling
Liver transplantation has become established as a reasonable and promising treatment option in terminal stages of liver diseases. Since there is no permanent artificial liver support available, primary "non-function" (PNF) of the graft is one of the most threatening complications. Therefore, an early and, if possible, intraoperative assessment of liver function is essential. Pathological changes in total oxygen consumption (VO2) are considered as an early indicator for the occurrence of PNF. Previously, PNF was analyzed using extensive calculations according to the Fick method, but since inauguration of the PhysioFlex anaesthesia device (Dräger, Lübeck, Germany), which is based on a closed anaesthesia circuit, continuous monitoring of oxygen consumption has become possible...
2001: Anaesthesiologie und Reanimation
T E Starzl, N Murase, A Demetris, M Trucco, J Fung
The evolution of clinical transplantation has hinged on 2 seminal turning points. The first was the demonstration in 1953 by Billingham, Brent, and Medawar that chimerism-associated tolerance could be induced deliberately in neonatal mice by infusing adult donor hematolymphopoietic cells. This discovery escalated in a straight line over the next 15 years to successful bone marrow transplantation in humans. The second turning point was the demonstration that organ allografts could self-induce tolerance under an umbrella of immunosuppression, or in some species without immunosuppression...
2000: Seminars in Liver Disease
C Derancourt, M Senser, L Atallah, M C Becker, R Laurent
BACKGROUND: We report two cases of generalized granuloma annulare occurring in photoexposed areas in two liver transplant recipients. CASE REPORTS: Case 1 was a 65-year-old man who had undergone liver transplantation in 1992. He was given immunosuppressive and antihypertensive therapy. Within 18 months of transplantation, he developed a confluent rash with maculae on sun-exposed areas (neck opening, nape, arms) and sparing the undershirt area. Clinical examination was normal...
August 2000: Annales de Dermatologie et de Vénéréologie
K Vahédi, F Gomez-Joly, D Samuel, D Azoulay, E Savier, Y Panis, J F Emile, D Castaing, H Bismuth, C Matuchansky, B Messing
OBJECTIVE: We report the digestive, hepatic, intestinal and nutritional history of the first combined liver-small bowel transplantation performed in France in an adult recipient. Currently, the clinical course has been favorable at 30 months. METHODS: In May 1997, a 21-year-old man underwent a double liver-small bowel transplantation for irreversible chronic bowel failure with severe chronic liver disease subsequent to post-surgical short-bowel syndrome. After 28 laparotomies, there were 15 cm of small bowel left for the gastric anastomosis...
December 18, 1999: La Presse Médicale
Leushner, Wu, Wang, Howson, Metrakos
Background: Because spontaneous microchimerism has been reported in stable renal and hepatic allografts, the presence of donor-derived cells in recipient tissues was investigated in kidney and liver tranplant recipients. Methods and Results: Human lymphocyte antigen class II markers and Y-chromosome sequences in male donor-to-female recipient transplants were used for chimeric analysis. Human lymphocyte antigen typing was performed by group-specific polymerase chain reaction amplification and restriction fragment length polymorphism analysis, X-chromosome- and Y-chromosome-specific primers were used in a multiplex polymerase chain reaction analysis...
September 1997: Molecular Diagnosis
T L Marchioro, C Hougie, H Ragde, R B Epstein, E D Thomas
The concentration of factor VIII and partial thromboplastin times became normal and have remained normal for 140 days after orthotopic tranplantation of a normal liver to a hemophilic dog. Transplantation of a normal spleen into a hemophilic recipient did not result in a significant increase in factor VIII although the splenic graft was viable for at least 47 days. Transplantation of normal marrow to a lethally irradiated hemophilic dog did not result in an increase in factor VIII during 34 days of observation...
January 10, 1969: Science
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