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https://www.readbyqxmd.com/read/28216728/marine-and-other-aquatic-dermatoses
#1
Surg Capt Jandhyala Sridhar, Surg Cdr Rajeev Deo
Occupational and recreational aquatic activity predisposes our population to a wide variety of dermatoses. Sunburn, urticaria, jellyfish stings, and contact dermatitis to rubber equipment are common allergies that are encountered in the aquatic environment. Among the infections, tinea versicolor, intertrigo, and verruca vulgaris are widespread. Swimmer's itch may occur due to skin penetration by schistosome cercariae, while free-floating nematocysts of marine coelenterates may precipitate seabather's eruption...
January 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28203266/occupational-contact-dermatitis-from-protein-in-sea-products-who-is-the-most-affected-the-fisherman-or-the-chef
#2
B Loddé, P Cros, A M Roguedas-Contios, R Pougnet, D Lucas, J D Dewitte, L Misery
BACKGROUND: Protein contact dermatitis has frequently been reported in case studies (usually in cases involving contact with seafood products), but there are very few descriptive series. The objectives of this present study were firstly to determine the incidence of protein contact dermatitis among fishermen in France and compare it with data from onshore work involving seafood exposure. Second, to discover what factors could explain any differences. In order to answer these questions we analysed data from the French national occupational disease surveillance and prevention network (RNV3P) and occupational diseases declared to the French National Network for Monitoring and Prevention of Occupational Disease...
2017: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/28168422/contact-allergy-to-preservatives-in-patients-with-occupational-contact-dermatitis-and-exposure-analysis-of-preservatives-in-registered-chemical-products-for-occupational-use
#3
Jakob Ferløv Schwensen, Ulrik Fischer Friis, Torkil Menné, Mari-Ann Flyvholm, Jeanne Duus Johansen
PURPOSE: The aim of the study is to investigate risk factors for sensitization to preservatives and to examine to which extent different preservatives are registered in chemical products for occupational use in Denmark. METHODS: A retrospective epidemiological observational analysis of data from a university hospital was conducted. All patients had occupational contact dermatitis and were consecutively patch tested with 11 preservatives from the European baseline series and extended patch test series during a 5-year period: 2009-2013...
February 6, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28153749/energy-landscape-of-a-gstp1-polymorph-linked-with-cytological-function-decay-in-response-to-chemical-stressors
#4
Zarrin Basharat, Azra Yasmin
Gene polymorphisms lead to varied structure and functional properties. A single nucleotide polymorphism (SNP) i.e. Ile105Val (rs1695) in glutathione S-transferase P1 (GSTP1) gene influences cytological toxicity and modulates the risk to occupational diseases. Apart from this, cancer, neuropathy, NOx, SOx and ozone mediated respiratory function decline including lung inflammation, asthma, allergy etc., have been reported in people with this missense mutation. Here, the functional properties of rs1695 polymorph are revisited through a computational approach...
April 20, 2017: Gene
https://www.readbyqxmd.com/read/28142300/dose-dependent-immunomodulating-effects-of-endotoxin-in-allergic-airway-inflammation
#5
Sudhir Kumar, Atin Adhikari
How very high exposure levels to endotoxin in a farming environment provide protection against respiratory allergic symptoms and low-to-moderate levels of endotoxin in urban homes promote allergic response is unclear. Dose-specific bacterial endotoxin or LPS-induced tolerance mechanisms can affect lung inflammations, coupled with the Th2 immune responses. Here, we explored the effects of intranasal exposure of LPS at two different doses (based on occupational exposures during handling of agricultural wastes) in OVA-sensitized allergic wild type (WT) and TLR4-KO mice, particularly, with respect to Th2 cytokines and Tregs level...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/28141629/a-wide-scope-of-new-developments-in-occupational-allergy-and-clinical-immunology
#6
Susan M Tarlo, Piero Maestrelli
No abstract text is available yet for this article.
January 30, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28138235/interactions-between-single-nucleotide-polymorphism-of-serpina1-gene-and-smoking-in-association-with-copd-a-case-control-study
#7
Xiaowei Deng, Cun-Hua Yuan, De Chang
BACKGROUND: SERPINA1 gene has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD), while smoking is a known risk factor for COPD. Little is known on the effect of SERPINA1 gene and its interaction with smoking in the Chinese population. In this study, the effect of SERPINA1 gene polymorphisms on COPD risk and its interaction with smoking status has been investigated. METHOD: A total of 120 COPD patients and 481 healthy controls were recruited at The Armed Police Corps Hospital...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28110709/chromium-vi-contact-dermatitis-getting-closer-to-understanding-the-underlying-mechanisms-of-toxicity-and%C3%A2-sensitization
#8
Jeroen Buters, Tilo Biedermann
Various haptens trigger innate immune pathways and/or induce cytotoxicity as a part of sensitization. Adam et al. decipher in vitro the mechanisms by which chromium(VI) induces inflammation, the likely prerequisites for toxicity, sensitization, and allergic contact dermatitis against chromium(VI). Importantly, and in line with other observations, chromium(VI), but not chromium(III) (or Ni(II)), induces mitochondrial reactive oxygen species accumulation. Mitochondrial reactive oxygen species in turn activate the NLRP3 inflammasome, allowing increased IL-1β processing and secretion, which likely underlies both chromium(VI)-induced cutaneous toxicity and sensitization...
February 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28093332/chitin-and-chitinase-role-in-pathogenicity-allergenicity-and-health
#9
REVIEW
Seema Patel, Arun Goyal
Chitin, a polysaccharide with particular abundance in fungi, nematodes and arthropods is immunogenic. It acts as a threat to other organisms, to tackle which they have been endowed with chitinase enzyme. Even if this enzyme is not present in all organisms, they possess proteins having chitin-binding domain(s) (ChtBD). Many lethal viruses like Ebola, and HCV (Hepatitis C virus) have these domains to manipulate their carriers and target organisms. In keeping with the basic rule of survival, the self-origin (own body component) chitins and chitinases are protective, but that of non-self origin (from other organisms) are detrimental to health...
April 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28050486/patch-test-as-a-diagnostic-tool-in-hand-eczema
#10
Natarajan Vigneshkarthik, Satyaki Ganguly, Sheela Kuruvila
INTRODUCTION: Allergic contact dermatitis is an important cause of hand eczema. Patch testing is the only investigation available to prove the diagnosis of allergic contact dermatitis. Exposures to allergens differ according to geographical, occupational, economic and social factors. Accordingly, patterns of allergic contact dermatitis differ in different parts of the world and different regions of the same country. AIM: To study the causes of allergic contact dermatitis in adult patients with hand eczema with the help of patch testing...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28039304/allergen-valency-dose-and-fc%C3%AE%C2%B5ri-occupancy-set-thresholds-for-secretory-responses-to-pen-a-1-and-motivate-design-of-hypoallergens
#11
Avanika Mahajan, Lama A Youssef, Cédric Cleyrat, Rachel Grattan, Shayna R Lucero, Christopher P Mattison, M Frank Erasmus, Bruna Jacobson, Lydia Tapia, William S Hlavacek, Mark Schuyler, Bridget S Wilson
Ag-mediated crosslinking of IgE-FcεRI complexes activates mast cells and basophils, initiating the allergic response. Of 34 donors recruited having self-reported shrimp allergy, only 35% had significant levels of shrimp-specific IgE in serum and measurable basophil secretory responses to rPen a 1 (shrimp tropomyosin). We report that degranulation is linked to the number of FcεRI occupied with allergen-specific IgE, as well as the dose and valency of Pen a 1. Using clustered regularly interspaced palindromic repeat-based gene editing, human RBL(rαKO) cells were created that exclusively express the human FcεRIα subunit...
February 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28039199/occupational-allergy-to-fruit-flies-drosophila-melanogaster-in-laboratory-workers
#12
Meinir Jones, Sue Blair, Stephanie MacNeill, Jennifer Welch, Alice Hole, Peter Baxter, Paul Cullinan
OBJECTIVES: Drosophila melanogaster (the 'fruit fly') is commonly used in genetic research, but there is only one report of IgE-associated allergy in exposed workers. 4 newly identified cases prompted us to examine the extent of this problem in a university laboratory. Our aim in this study is to determine the prevalence and determinants of sensitisation to fruit flies in a population of exposed workers. METHODS: In a cross-sectional study, we surveyed 286 employees working in a department carrying out research involving D...
December 30, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28032352/patch-testing-with-rubber-series-in-europe-a-critical-review-and-recommendation
#13
Katharine L Warburton, Wolfgang Uter, Johannes Geier, Radoslaw Spiewak, Vera Mahler, Marie-Noëlle Crépy, Marie-Louise Schuttelaar, Andrea Bauer, Mark Wilkinson
BACKGROUND: Rubber additives constitute an important group of contact allergens, particularly in certain occupations. OBJECTIVES: To collect information regarding the current practice of using a 'rubber series' in Europe, and discuss this against the background of evidence concerning the prevalence of allergy in order to derive a recommendation for a 'European rubber series'. METHODS: The following were performed: (i) a survey targeting all members of the COST action 'StanDerm' consortium, (ii) analysis of rubber contact allergy data in the database of the European Surveillance System on Contact Allergies, and (iii) a literature review...
December 28, 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/28007673/rubber-new-allergens-and-preventive-measures
#14
Marie-Noëlle Crepy
Natural rubber latex (NRL) and rubber accelerators are well-known causes of occupational skin diseases. The latest epidemiological data on rubber allergy show that rubber additives are still among the allergens most strongly associated with occupational contact dermatitis, however, a decrease in NRL allergy has been confirmed. A review of recent publications on rubber allergens based on the Pubmed database is presented. New glove manufacturing processes have been developed, such as low-protein natural rubber gloves, vulcanisation accelerator-free gloves, or specific-purpose gloves containing antimicrobial agents or moisturisers...
December 1, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27924689/hymenoptera-venom-allergy-in-outdoor-workers-occupational-exposure-clinical-features-and-effects-of-allergen-immunotherapy
#15
Alessandra Toletone, Susanna Voltolini, Giovanni Passalacqua, Guglielmo Dini, Donatella Bignardi, Paola Minale, Emanuela Massa, Alessio Signori, Costantino Troise, Paolo Durando
OBJECTIVES: To describe (i) the clinical characteristics of workers, exposed to hymenoptera stings, with an ascertained diagnosis of Hymenoptera Venom Allergy (HVA), (ii) the specific role of occupational exposure, (iii) the effect of Venom Immunotherapy (VIT) in reducing the severity of allergic episodes in workers exposed to repeated stings of hymenoptera, and (iv) the management of the occupational consequences caused by allergic reactions due to hymenoptera stings. METHODS: Between 2000 and 2013 an observational study, including patients referred to the regional reference hospital of Liguria, Italy, with an ascertained diagnosis of HVA and treated with VIT, was performed...
February 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27853040/an-epidemiological-profile-of-chronic-obstructive-pulmonary-disease-a-community-based-study-in-delhi
#16
B Sinha, R Singla, R Chowdhury
BACKGROUND: Different definitions used for chronic obstructive pulmonary disease (COPD) preclude getting reliable prevalence estimates. Study objective was to find the prevalence of COPD as per standard Global Initiative for Chronic Obstructive Lung Disease definition, risk factors associated, and treatment seeking in adults >30 years. METHODOLOGY: Community-based cross-sectional study was conducted in Delhi, among 1200 adults, selected by systematic random sampling...
November 16, 2016: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/27819696/sensitization-to-occupational-allergens-in-hairdressing-apprentices-diagnosed-already-before-entering-vocational-training
#17
Aleksandra Golińska-Zach, Patrycja Krawczyk-Szulc, Marta Wiszniewska, Ewa Nowakowska-Świrta, Dominika Świerczyńska-Machura, Diana Tymoszuk, Jolanta Walusiak-Skorupa
BACKGROUND: Hairdressers are occupationally exposed to many allergenic and irritating substances. Additionally, hairdressing apprentices are exposed to the same allergens as professional hairdressers, due to the fact that vocational training starts in the beginning of the education. This study was undertaken to investigate early occurrence of sensitization to occupational allergens in hairdressing apprentices before the onset of the vocational training. MATERIAL AND METHODS: Three hundred and seven hairdressing apprentices were assessed using a questionnaire and skin prick tests (SPTs) to common and occupational allergens...
2016: Medycyna Pracy
https://www.readbyqxmd.com/read/27768241/factors-associated-with-combined-hand-and-foot-eczema-associations-between-foot-and-hand-eczema
#18
T Agner, K Aalto-Korte, K E Andersen, C Foti, A Gimenéz-Arnau, M Goncalo, A Goossens, C Le Coz, T L Diepgen
BACKGROUND: As for hand eczema, the etiology of foot eczema is multifactorial, and not very well understood. The aim of the present study was to identify factors associated with foot eczema in a cohort of hand eczema patients being classified into different subgroups. METHODS: Associations between foot and hand eczema was studied in a cross sectional design in a cohort of hand eczema patients. Consecutive patients were recruited from 9 different European Centres during the period October 2011 - September 2012...
October 21, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27760535/the-haiti-medical-education-project-development-and-analysis-of-a-competency-based-continuing-medical-education-course-in-haiti-through-distance-learning
#19
EDITORIAL
Robert Battat, Marc Jhonson, Lorne Wiseblatt, Cruff Renard, Laura Habib, Manouchka Normil, Brian Remillard, Timothy F Brewer, Galit Sacajiu
BACKGROUND: Recent calls for reform in healthcare training emphasize using competency-based curricula and information technology-empowered learning. Continuing Medical Education programs are essential in maintaining physician accreditation. Haitian physicians have expressed a lack access to these activities. The Haiti Medical Education Project works in alliance with Haitian medical leadership, faculty and students to support the Country's medical education system. We present the creation, delivery and evaluation of a competency-based continuing medical education curriculum for physicians in rural Haiti...
October 19, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27751866/allergy-inducing-chromium-compounds-trigger-potent-innate-immune-stimulation-via-ros-dependent-inflammasome-activation
#20
Christian Adam, Jonas Wohlfarth, Maike Haußmann, Helga Sennefelder, Annette Rodin, Mareike Maler, Stefan F Martin, Matthias Goebeler, Marc Schmidt
Chromium allergy is a common occupational skin disease mediated by chromium (VI)-specific T cells that induce delayed-type hypersensitivity in sensitized individuals. Additionally, chromium (VI) can act as an irritant. Both responses critically require innate immune activation, but if and how chromium (VI) elicits this signal is currently unclear. Using human monocytes, primary human keratinocytes, and murine dendritic cells we show that chromium (VI) compounds fail to trigger direct proinflammatory activation but potently induce processing and secretion of IL-1β...
October 14, 2016: Journal of Investigative Dermatology
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