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https://www.readbyqxmd.com/read/28050486/patch-test-as-a-diagnostic-tool-in-hand-eczema
#1
Natarajan Vigneshkarthik, Satyaki Ganguly, Sheela Kuruvila
INTRODUCTION: Allergic contact dermatitis is an important cause of hand eczema. Patch testing is the only investigation available to prove the diagnosis of allergic contact dermatitis. Exposures to allergens differ according to geographical, occupational, economic and social factors. Accordingly, patterns of allergic contact dermatitis differ in different parts of the world and different regions of the same country. AIM: To study the causes of allergic contact dermatitis in adult patients with hand eczema with the help of patch testing...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28039304/allergen-valency-dose-and-fc%C3%AE%C2%B5ri-occupancy-set-thresholds-for-secretory-responses-to-pen-a-1-and-motivate-design-of-hypoallergens
#2
Avanika Mahajan, Lama A Youssef, Cédric Cleyrat, Rachel Grattan, Shayna R Lucero, Christopher P Mattison, M Frank Erasmus, Bruna Jacobson, Lydia Tapia, William S Hlavacek, Mark Schuyler, Bridget S Wilson
Ag-mediated crosslinking of IgE-FcεRI complexes activates mast cells and basophils, initiating the allergic response. Of 34 donors recruited having self-reported shrimp allergy, only 35% had significant levels of shrimp-specific IgE in serum and measurable basophil secretory responses to rPen a 1 (shrimp tropomyosin). We report that degranulation is linked to the number of FcεRI occupied with allergen-specific IgE, as well as the dose and valency of Pen a 1. Using clustered regularly interspaced palindromic repeat-based gene editing, human RBL(rαKO) cells were created that exclusively express the human FcεRIα subunit...
December 30, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28039199/occupational-allergy-to-fruit-flies-drosophila-melanogaster-in-laboratory-workers
#3
Meinir Jones, Sue Blair, Stephanie MacNeill, Jennifer Welch, Alice Hole, Peter Baxter, Paul Cullinan
OBJECTIVES: Drosophila melanogaster (the 'fruit fly') is commonly used in genetic research, but there is only one report of IgE-associated allergy in exposed workers. 4 newly identified cases prompted us to examine the extent of this problem in a university laboratory. Our aim in this study is to determine the prevalence and determinants of sensitisation to fruit flies in a population of exposed workers. METHODS: In a cross-sectional study, we surveyed 286 employees working in a department carrying out research involving D...
December 30, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28032352/patch-testing-with-rubber-series-in-europe-a-critical-review-and-recommendation
#4
Katharine L Warburton, Wolfgang Uter, Johannes Geier, Radoslaw Spiewak, Vera Mahler, Marie-Noëlle Crépy, Marie-Louise Schuttelaar, Andrea Bauer, Mark Wilkinson
BACKGROUND: Rubber additives constitute an important group of contact allergens, particularly in certain occupations. OBJECTIVES: To collect information regarding the current practice of using a 'rubber series' in Europe, and discuss this against the background of evidence concerning the prevalence of allergy in order to derive a recommendation for a 'European rubber series'. METHODS: The following were performed: (i) a survey targeting all members of the COST action 'StanDerm' consortium, (ii) analysis of rubber contact allergy data in the database of the European Surveillance System on Contact Allergies, and (iii) a literature review...
December 28, 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/28007673/rubber-new-allergens-and-preventive-measures
#5
Marie-Noëlle Crepy
Natural rubber latex (NRL) and rubber accelerators are well-known causes of occupational skin diseases. The latest epidemiological data on rubber allergy show that rubber additives are still among the allergens most strongly associated with occupational contact dermatitis, however, a decrease in NRL allergy has been confirmed. A review of recent publications on rubber allergens based on the Pubmed database is presented. New glove manufacturing processes have been developed, such as low-protein natural rubber gloves, vulcanisation accelerator-free gloves, or specific-purpose gloves containing antimicrobial agents or moisturisers...
December 1, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27924689/hymenoptera-venom-allergy-in-outdoor-workers-occupational-exposure-clinical-features-and-effects-of-allergen-immunotherapy
#6
Alessandra Toletone, Susanna Voltolini, Giovanni Passalacqua, Guglielmo Dini, Donatella Bignardi, Paola Minale, Emanuela Massa, Alessio Signori, Costantino Troise, Paolo Durando
OBJECTIVES: To describe (i) the clinical characteristics of workers, exposed to hymenoptera stings, with an ascertained diagnosis of Hymenoptera Venom Allergy (HVA), (ii) the specific role of occupational exposure, (iii) the effect of Venom Immunotherapy (VIT) in reducing the severity of allergic episodes in workers exposed to repeated stings of hymenoptera, and (iv) the management of the occupational consequences caused by allergic reactions due to hymenoptera stings. METHODS: Between 2000 and 2013 an observational study, including patients referred to the regional reference hospital of Liguria, Italy, with an ascertained diagnosis of HVA and treated with VIT, was carried out...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27853040/an-epidemiological-profile-of-chronic-obstructive-pulmonary-disease-a-community-based-study-in-delhi
#7
B Sinha, R Singla, R Chowdhury
BACKGROUND: Different definitions used for chronic obstructive pulmonary disease (COPD) preclude getting reliable prevalence estimates. Study objective was to find the prevalence of COPD as per standard Global Initiative for Chronic Obstructive Lung Disease definition, risk factors associated, and treatment seeking in adults >30 years. METHODOLOGY: Community-based cross-sectional study was conducted in Delhi, among 1200 adults, selected by systematic random sampling...
November 16, 2016: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/27819696/sensitization-to-occupational-allergens-in-hairdressing-apprentices-diagnosed-already-before-entering-vocational-training
#8
Aleksandra Golińska-Zach, Patrycja Krawczyk-Szulc, Marta Wiszniewska, Ewa Nowakowska-Świrta, Dominika Świerczyńska-Machura, Diana Tymoszuk, Jolanta Walusiak-Skorupa
BACKGROUND: Hairdressers are occupationally exposed to many allergenic and irritating substances. Additionally, hairdressing apprentices are exposed to the same allergens as professional hairdressers, due to the fact that vocational training starts in the beginning of the education. This study was undertaken to investigate early occurrence of sensitization to occupational allergens in hairdressing apprentices before the onset of the vocational training. MATERIAL AND METHODS: Three hundred and seven hairdressing apprentices were assessed using a questionnaire and skin prick tests (SPTs) to common and occupational allergens...
2016: Medycyna Pracy
https://www.readbyqxmd.com/read/27768241/factors-associated-with-combined-hand-and-foot-eczema-associations-between-foot-and-hand-eczema
#9
T Agner, K Aalto-Korte, K E Andersen, C Foti, A Gimenéz-Arnau, M Goncalo, A Goossens, C Le Coz, T L Diepgen
BACKGROUND: As for hand eczema, the etiology of foot eczema is multifactorial, and not very well understood. The aim of the present study was to identify factors associated with foot eczema in a cohort of hand eczema patients being classified into different subgroups. METHODS: Associations between foot and hand eczema was studied in a cross sectional design in a cohort of hand eczema patients. Consecutive patients were recruited from 9 different European Centres during the period October 2011 - September 2012...
October 21, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27760535/the-haiti-medical-education-project-development-and-analysis-of-a-competency-based-continuing-medical-education-course-in-haiti-through-distance-learning
#10
EDITORIAL
Robert Battat, Marc Jhonson, Lorne Wiseblatt, Cruff Renard, Laura Habib, Manouchka Normil, Brian Remillard, Timothy F Brewer, Galit Sacajiu
BACKGROUND: Recent calls for reform in healthcare training emphasize using competency-based curricula and information technology-empowered learning. Continuing Medical Education programs are essential in maintaining physician accreditation. Haitian physicians have expressed a lack access to these activities. The Haiti Medical Education Project works in alliance with Haitian medical leadership, faculty and students to support the Country's medical education system. We present the creation, delivery and evaluation of a competency-based continuing medical education curriculum for physicians in rural Haiti...
October 19, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27751866/allergy-inducing-chromium-compounds-trigger-potent-innate-immune-stimulation-via-ros-dependent-inflammasome-activation
#11
Christian Adam, Jonas Wohlfarth, Maike Haußmann, Helga Sennefelder, Annette Rodin, Mareike Maler, Stefan F Martin, Matthias Goebeler, Marc Schmidt
Chromium allergy is a common occupational skin disease mediated by chromium (VI)-specific T cells that induce delayed-type hypersensitivity in sensitized individuals. Additionally, chromium (VI) can act as irritant. Both responses critically require innate immune activation, but if and how chromium (VI) elicits this signal is currently unclear.Using human monocytes, primary human keratinocytes and murine dendritic cells we show that chromium (VI) compounds fail to trigger direct proinflammatory activation but potently induce processing and secretion of IL-1β...
October 14, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27734174/medical-surveillance-and-long-term-prognosis-of-occupational-allergy-due-to-platinum-salts
#12
Rolf Merget, Ngoc Pham, Maike Schmidtke, Swaantje Casjens, Vera van Kampen, Ingrid Sander, Olaf Hagemeyer, Kirsten Sucker, Monika Raulf, Thomas Brüning
PURPOSE: Medical surveillance of workers in precious metals refineries and catalyst production plants is well established in many countries as a measure to prevent occupational asthma due to platinum (Pt) salts. It was the aim of this study to evaluate the impact of medical surveillance and to define prognostic factors with an emphasis on exposure determinants. METHODS: As part of an observational longitudinal study, 96 workers from German precious metals refineries and catalyst production plants with Pt salt allergy underwent a second examination several years (median 67 months) after the initial diagnosis was made...
October 12, 2016: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/27698299/climate-change-and-occupational-allergies-an-overview-on-biological-pollution-exposure-and-prevention
#13
Maria Concetta D'Ovidio, Isabella Annesi-Maesano, Gennaro D'Amato, Lorenzo Cecchi
INTRODUCTION: Climate change, air pollution, temperature increase and other environmental variables are modifying air quality, contributing to the increase of prevalence of allergic respiratory diseases. Allergies are complex diseases characterized by multilevel interactions between individual susceptibility, response to immune modulation and environmental exposures to physical, chemical and biological agents. Occupational allergies introduce a further complexity to these relationships by adding occupational exposure to both the indoor and outdoor ones in the living environment...
July 2016: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/27659009/chromate-and-amine-contact-allergies-in-workers-manufacturing-precast-concrete-elements
#14
Martin Mowitz, Erik Zimerson, Inese Hauksson, Ann Pontén
BACKGROUND: Five workers from a plant manufacturing concrete wall panels and beams were referred to our department because of suspected occupational dermatitis. When patch tested, 3 workers reacted to potassium dichromate. Four workers reacted to ethylenediamine dihydrochloride, without any obvious exposure. Owing to the high proportion of workers with recent-onset skin disease, an investigation of all workers at the plant was initiated. OBJECTIVES: To investigate the prevalence of occupational dermatitis and contact allergy in the workers at the plant...
December 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27637271/occupational-exposure-to-the-municipal-solid-waste-workers-in-chandigarh-india
#15
Khaiwal Ravindra, Kamalpreet Kaur, Suman Mor
Manual handling of municipal solid waste is of serious concern owing to emerging occupational risks. Considering this, health risks of municipal solid waste workers involved in street sweeping, waste collection, waste processing and rag picking were assessed in Chandigarh, India, using an interview schedule as a study tool. Result shows that the waste worker profession is mainly dominated by males, except in rag pickers, and with a lower literacy rate. Age distribution shows that 16% of waste collectors and 11% of rag pickers were below 18 years of age...
November 2016: Waste Management & Research
https://www.readbyqxmd.com/read/27633770/patterns-of-simultaneous-patch-test-reactions-to-thiurams-and-dithiocarbamates-in-164-patients
#16
Kristiina Aalto-Korte, Maria Pesonen
BACKGROUND: Thiurams and dithiocarbamates are structurally related sensitizing rubber accelerators. OBJECTIVES: To study patterns of simultaneous patch test reactions to thiurams and dithiocarbamates at the Finnish Institute of Occupational Health in 1991-2015. METHODS: We searched the patch test files for patients with allergic reactions to thiuram mix, its four components, and three dithiocarbamates, and analysed patterns of simultaneous reactions to these test substances...
December 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27616168/occupational-allergy
#17
Tamotsu Ishizuka, Miwa Morikawa
No abstract text is available yet for this article.
August 2016: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/27591452/-nickel-role-in-human-organism-and-toxic-effects
#18
REVIEW
Zygmunt Zdrojewicz, Ewa Popowicz, Jacek Winiarski
The aim of this study is to familiarize the Role of nickel in the Environment and in living organisms. This metal is widely used in many fields such as electrical engineering, medicine, Jewellery or Automotive Industry. Furthermore, it's an important part of our food. As the central atom of bacterial enzymes it participates in degradation of urea.. Nickel is also an micronutritient essential for proper functioning of the human body, as it increases hormonal activity and is involved in lipid metabolism. This metal makes it's way to the human body through respiratory tract, digestive system and skin...
August 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27590657/-nickel-role-in-human-organism-and-toxic-effects
#19
REVIEW
Zygmunt Zdrojewicz, Ewa Popowicz, Jacek Winiarski
The aim of this study is to familiarize the Role of nickel in the Environment and in living organisms. This metal is widely used in many fields such as electrical engineering, medicine, Jewellery or Automotive Industry. Furthermore, it's an important part of our food. As the central atom of bacterial enzymes it participates in degradation of urea.. Nickel is also an micronutritient essential for proper functioning of the human body, as it increases hormonal activity and is involved in lipid metabolism. This metal makes it's way to the human body through respiratory tract, digestive system and skin...
July 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27581504/career-advice-for-young-allergy-patients
#20
Katja Radon, Dennis Nowak, Christian Vogelberg, Franziska Ruëff
BACKGROUND: One-third of all young persons entering the work force have a history of atopic disease. Occupationally induced allergy and asthma generally arise in the first few months on the job, while pre-existing symptoms tend to worsen. Young persons with a history of an atopic disease should receive evidence-based advice before choosing a career. METHODS: We systematically searched PubMed for cohort studies investigating the new onset of asthma, rhinitis, or hand eczema among job trainees from before the start of training and onward into the first few years on the job...
August 8, 2016: Deutsches Ärzteblatt International
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