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https://www.readbyqxmd.com/read/29686953/prevalence-and-associated-risk-factors-of-bronchial-asthma-in-children-in-santo-domingo-dominican-republic
#1
Stephanie G Mejias, Kamleshun Ramphul
Background Bronchial asthma is an important health problem worldwide. There is insufficient data on the prevalence of bronchial asthma among school children in Santo Domingo, Dominican Republic. Objective The objective of this study is to assess the prevalence of asthma and its related risk factors among school children in Santo Domingo, Dominican Republic. Materials and methods A cross-sectional study using a modified questionnaire was conducted in Santo Domingo among 600 children aged three to 11 eleven years...
February 20, 2018: Curēus
https://www.readbyqxmd.com/read/29685015/importance-of-basophils-in-eosinophilic-asthma-the-murine-counterpart
#2
D Poddighe, C B Mathias, I Brambilla, G L Marseglia, H C Oettgen
Several experimental studies in mice showed that basophils participate in the initiation of Th2 adaptive immune response, in addition to the effector phase. However, the role of basophils in allergic airway inflammation is less clear. The aim of this experiment was to assess the importance of basophils in recruiting inflammatory cells and, in particular, eosinophils in a murine model of asthma induced by Aspergillus fumigatus allergens. Additionally, bronchial reactivity was evaluated. Basophil depletion resulted in a reduction of inflammatory cells in the airways and eosinophil recruitment was significantly impaired...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29680839/decreased-migration-of-dendritic-cells-into-the-jugular-nodose-ganglia-by-the-cxcl12-neutraligand-chalcone-4-in-ovalbumin-sensitized-asthmatic-mice
#3
Sebastian Heck, François Daubeuf, Duc Dung Le, Martina Sester, Dominique Bonnet, Robert Bals, Nelly Frossard, Quoc Thai Dinh
OBJECTIVE: The chemokine CXCL12 interacting with the CXC receptor 4 (CXCR4) has been reported to play a role in the development and progression of bronchial asthma, but its mechanism of action is still unknown. The objective of this study was to assess the effect of the CXCL12 neutraligand chalcone 4 on the migration of dendritic cells (DCs) in a murine model of allergic airway inflammation. METHODS: A 21-day ovalbumin (OVA)-induced allergic-airway TH2 inflammation model in BALB/c mice was used...
April 20, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29676639/effects-of-controlled-diesel-exhaust-and-allergen-exposure-on-microrna-and-gene-expression-in-humans-modulation-of-lung-inflammatory-markers-associated-with-asthma
#4
Christopher F Rider, Masatsugu Yamamoto, Oliver P Günther, Amrit Singh, Jeremy A Hirota, Scott J Tebbutt, Christopher Carlsten
RATIONALE: Air pollution may contribute to the development of allergic diseases, including asthma, by enhancing immune responses to allergen, but the effects on microRNA, messenger RNA, and inflammatory markers remain unexplored. OBJECTIVES: To determine if acute exposure to diesel exhaust and/or allergen alters expression of microRNA and genes with effects on inflammatory markers associated with asthma. METHODS: Fifteen atopic participants were exposed in a crossover trial to inhaled filtered air or diesel exhaust (DE; 300 μg particulate matter with aerodynamic diameter less than or equal to 2...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676195/in-vitro-inhibitory-effects-of-sophocarpine-on-human-liver-cytochrome-p450-enzymes
#5
Jingwei Zhang, Chuansheng Li, Jingfa Zhang, Fan Zhang
1. Sophocarpine is a biologically active component isolated from the foxtail-like sophora herb and seed that is often orally administered for the treatment of cancer and chronic bronchial asthma. However, whether sophocarpine affects the activity of human liver cytochrome P450 (CYP) enzymes remains unclear. 2. In this study, the inhibitory effects of sophocarpine on the eight human liver CYP isoforms (CYP1A2, 3A4, 2A6, 2E1, 2D6, 2C9, 2C19, and 2C8) were investigated in vitro using human liver microsomes (HLMs)...
April 20, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29676073/overexpression-of-mir-155-5p-inhibits-the-proliferation-and-migration-of-il-13-induced-human-bronchial-smooth-muscle-cells-by-suppressing-tgf-%C3%AE-activated-kinase-1-map3k7-binding-protein-2
#6
Yujia Shi, Xingli Fu, Qi Cao, Zhengdao Mao, Yi Chen, Yun Sun, Zhiguang Liu, Qian Zhang
PURPOSE: Molecular mechanisms leading to asthma is still ill-defined. Though the function of microRNAs (miRNAs) in asthma was previously reported, the involvement of miR-155 in important features of this disease remains unknown. The present study was designed to uncover the probable involvement of miR-155-5p in the proliferation and migration of IL-13-induced human bronchial smooth muscle cells (BSMCs) and the intrinsic regulatory mechanism. METHODS: The effects of different concentrations of IL-13 on the proliferation and migration of BSMCs as well as the expression of miR-155-5p and its predicted target transforming growth factor (TGF)-β-activated kinase 1/MAP3K7-binding protein 2 (TAB2) were investigated...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29676068/trpv1-blocking-alleviates-airway-inflammation-and-remodeling-in-a-chronic-asthma-murine-model
#7
Joon Young Choi, Hwa Young Lee, Jung Hur, Kyung Hoon Kim, Ji Young Kang, Chin Kook Rhee, Sook Young Lee
PURPOSE: Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. There is emerging interest in the involvement of the transient receptor potential vanilloid 1 (TRPV1) channel in the pathophysiology of asthma. This study examined whether TRPV1 antagonism alleviates asthma features in a murine model of chronic asthma. METHODS: BALB/c mice were sensitized to and challenged by ovalbumin to develop chronic asthma...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29672862/aryl-hydrocarbon-receptor-activation-by-diesel-exhaust-particles-mediates-epithelium-derived-cytokines-expression-in-severe-allergic-asthma
#8
Chih-Ming Weng, Chun-Hua Wang, Meng-Jung Lee, Jung-Re He, Hsin-Yu Huang, Ming-Wei Chao, Kian Fan Chung, Han-Pin Kuo
BACKGROUND: Exposure to environmental pollutants promotes Th2 cell responses. Aryl hydrocarbon receptor (AhR) activation aggravates allergic responses. Epithelium-derived thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 and IL-33 are implicated in the dysregulation of Th2 immune responses in severe allergic asthma. METHODS: Bronchial biopsies of 28 allergic severe asthma and 6 mild asthma subjects from highly polluted areas were analyzed for AhR nuclear translocation (NT), cytokine expression and gene activation...
April 19, 2018: Allergy
https://www.readbyqxmd.com/read/29670027/a-review-of-evidence-for-a-therapeutic-application-of-traditional-japanese-kampo-medicine-for-oral-diseases-disorders
#9
REVIEW
Marie-Pier Veilleux, Satomi Moriyama, Masami Yoshioka, Daisuke Hinode, Daniel Grenier
Kampo medicines prescribed by specialized medical practitioners and Japanese physicians have gradually reemerged in Japan as alternatives to Western medications. Kampo formulations are composed of several plant extracts and, as such, the broad variety of phytochemicals they contain likely act synergistically to provide their beneficial effects. Kampo medicines have traditionally been prescribed for a number of health conditions, including chronic hepatitis, bronchial asthma, anemia, etc. The aim of this article is to review the beneficial effects of Kampos with respect to oral health...
April 18, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29669351/bronchial-thermoplasty-in-severe-asthma-best-practice-recommendations-from-an-expert-panel
#10
Peter I Bonta, Pascal Chanez, Jouke T Annema, Pallav L Shah, Robert Niven
Bronchial thermoplasty (BT) is a bronchoscopic treatment for patients with severe asthma who remain symptomatic despite optimal medical therapy. In this "expert best practice" paper, the background and practical aspects of BT are highlighted. Randomized, controlled clinical trials have shown BT to be safe and effective in reducing severe exacerbations, improving quality of life, and decreasing emergency department visits. Five-year follow-up studies have provided evidence of the functional stability of BT-treated patients with persistence of a clinical benefit...
April 17, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29668295/unravelling-a-clinical-paradox-why-does-bronchial-thermoplasty-work-in-asthma
#11
Graham M Donovan, John G Elliot, Francis H Y Green, Alan L James, Peter B Noble
Rationale Bronchial thermoplasty is a relatively new but effective treatment in asthmatic subjects who do not respond to conventional therapy. While the favoured mechanism is ablation of the airway smooth muscle layer, because bronchial thermoplasty treats only a small number of central airways, there is ongoing debate regarding its precise method of action. Objectives Elucidate the underlying method of action behind bronchial thermoplasty. Methods We employ a combination of extensive human lung specimens and novel computational methods...
April 18, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29667580/severe-asthma-phenotypes-classified-by-site-of-airway-involvement-and-remodeling-via-chest-ct-scan
#12
S Kim, K Nam Jin, S H Cho, C Hyun Lee, H R Kang
BACKGROUND AND OBJECTIVE: This study aimed to establish a system that can classify severe asthma on the basis of airway remodeling patterns visualized by computed tomography (CT) images and to evaluate the clinical characteristics of individual image-based subtypes. METHODS: Chest CT images of severe asthma patients were retrospectively evaluated to classify phenotypes by site of airway involvement and remodeling. The association between radiologic subtypes and clinical characteristics was assessed...
April 18, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29667525/the-association-between-bronchial-asthma-and-periodontitis-a-case-control-study-in-jordan
#13
Basheer Khassawneha, Rola Alhabashnehb, Fadi Ibrahimc
OBJECTIVE: Our aim is to study the association between bronchial asthma (BA) and periodontitis in northern Jordan. METHODS: A case-control study of 260 subjects; 130 with BA and 130 without BA (controls) were recruited from pulmonary clinics at a university hospital in northern Jordan. BA was physician diagnosed and on anti-asthma medications for ≥12 months. Periodontitis was defined as the presence of ≥ 4 teeth with ≥ 1 site with probing pocket depth (PPD) ≥ 4 mm and clinical attachment level (CAL) ≥ 3 mm...
April 18, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29667303/mir-146a-regulates-pm-1-induced-inflammation-via-nf-%C3%AE%C2%BAb-signaling-pathway-in-beas-2b-cells
#14
Limin Liu, Chong Wan, Wei Zhang, Longfei Guan, Guoxiong Tian, Fang Zhang, Wenjun Ding
Exposure to particulate matter (PM) leads to kinds of cardiopulmonary diseases, such as asthma, COPD, arrhythmias, lung cancer, etc., which are related to PM-induced inflammation. We have found that PM2.5 (aerodynamics diameter <2.5 µm) exposure induces inflammatory response both in vivo and in vitro. Since the toxicity of PM is tightly associated with its size and components, PM1 (aerodynamics diameter <1.0 µm) is supposed to be more toxic than PM2.5 . However, the mechanism of PM1 -induced inflammation is not clear...
April 18, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29658513/b-2-adrenergic-receptor-gene-polymorphism-effect-on-childhood-asthma-severity-and-response-to-treatment
#15
Ashgan Abdallah Alghobashy, Sahar A Elsharawy, Usama M Alkholy, Nermin Abdalmonem, Mohamed Ali Abdou, Maha A A Basset, Heba Fouad Pasha
BackgroundAlterations of B2 adrenergic receptor (β2 AR) can modulate the severity of asthma and the response to treatment. Therefore, we aimed to evaluate β2 AR gene polymorphism at codons 16 and 27 and their effect on asthma severity and response to treatment in asthmatic children.MethodsCase-control study was conducted on 156 children; 104 of them had bronchial asthma and 52 were healthy children (control group). Subjects of the study underwent history taking, clinical examination, pulmonary function tests, serum IgE level assessment, and identification of β2 AR-16 A46G and β2 AR-27 C79G polymorphism using PCR-Restriction Fragment length polymorphisms (RFLP) test...
March 2018: Pediatric Research
https://www.readbyqxmd.com/read/29656209/phosphorylation-of-low-density-lipoprotein-receptor-related-protein-6-is-involved-in-receptor-for-advanced-glycation-end-product-mediated-%C3%AE-catenin-stabilization-in-a-toluene-diisocyanate-induced-asthma-model
#16
Jing Xiong, Wenqu Zhao, Yun Lin, Lihong Yao, Guohua Huang, Changhui Yu, Hangming Dong, Guanhua Xiao, Haijin Zhao, Shaoxi Cai
BACKGROUND: We have previously demonstrated that the receptor for advanced glycation end products (RAGE)/β-catenin axis plays a vital role in regulating airway inflammation and airway remodeling in a toluene diisocyanate (TDI)-induced murine asthma model. However, the exact mechanism of β-catenin activation remains unclear. Given that phosphorylation of the low-density lipoprotein receptor-related protein 6 (Lrp6) is a key step in mediating β-catenin stabilization in canonical wnt/β-catenin signaling, we explored the possible relationship between RAGE and Lrp6 in regulating β-catenin stabilization in TDI-induced asthma...
April 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29652177/broncho-epithelial-iga-secretion-is-impaired-in-asthma-role-of-il-4-il-13
#17
Maha Zohra Ladjemi, Delphine Gras, Sébastien Dupasquier, Bruno Detry, Marylène Lecocq, Céline Garulli, Chantal Fregimilicka, Caroline Bouzin, Sophie Gohy, Pascal Chanez, Charles Pilette
RATIONALE: Asthma is associated with increased lung IgE production, but whether the secretory (S-)IgA system is affected in this disease remains unknown. OBJECTIVES: We explored mucosal IgA transport in human asthma and its potential regulation by Th2 inflammation. METHODS: Bronchial biopsies from asthma and control subjects were assayed for broncho-epithelial pIgR expression and correlated to Th2 biomarkers. Bronchial epithelium reconstituted in vitro from these subjects, upon culture in air-liquid interface, was assayed for pIgR expression and regulation by IL-4/IL-13...
April 13, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29651336/pi3k-p38-and-jak-stat-signalling-in-bronchial-tissue-from-patients-with-asthma-following-allergen-challenge
#18
Thomas Southworth, Sarah Mason, Alan Bell, Isabel Ramis, Marta Calbet, Anna Domenech, Neus Prats, Montserrat Miralpeix, Dave Singh
Background: Inhaled allergen challenges are often used to evaluate novel asthma treatments in early phase clinical trials. Current novel therapeutic targets in asthma include phosphoinositide 3-kinases (PI3K) delta and gamma, p38 mitogen-activated protein kinase (p38) and Janus kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signalling pathways. The activation of these pathways following allergen exposure in atopic asthma patients it is not known. Methods: We collected bronchial biopsies from 11 atopic asthma patients at baseline and after allergen challenge to investigate biomarkers of PI3K, p38 MAPK and JAK/STAT activation by immunohistochemistry...
2018: Biomarker Research
https://www.readbyqxmd.com/read/29650833/-a-case-of-local-recurrence-of-descending-colon-cancer-with-ileus-obstruction-and-lung-liver-and-brain-metastasis
#19
Ryouichi Tomita, Shigeru Fujisaki, Kenichi Sakurai, Takeo Azuhata, Yuko Takamoto
We report a 50-year-old man with local recurrence of descending colon cancer with ileus obstruction and brain metastasis, 2 years 6 months after initial resection due to perforation of descending colon cancer(Hartmann procedure, D2 lymph node resection, Stage II, tub2). He complained of left upper abdominal pain and abdominal fullness. He also complained of paresis of the right upper extremity and of experiencing convulsions 1 month before admission. He was diagnosed with local recurrence of descending colon cancer, based on findings of contrast radiography and the presence of colonic fiber...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650561/meta-analysis-of-airway-epithelia-gene-expression-in-asthma
#20
Yi-Hsuan Tsai, Joel S Parker, Ivana V Yang, Samir N P Kelada
Differential gene expression in the airway epithelium of asthmatics vs. controls has been reported in several studies. However, there is no consensus on which genes are reproducibly affected in asthma. We sought to identify a consensus list of differentially expressed genes (DEGs) using a meta-analysis approach.We identified eight studies with data that met defined inclusion criteria. In total, these studies were comprised of 355 cases and 193 controls and involved sampling of either bronchial or nasal epithelium...
April 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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