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Asthma bronchiale

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https://www.readbyqxmd.com/read/29916550/epigallocatechin-gallate-improves-airway-inflammation-through-tgf%C3%A2-%C3%AE-1-signaling-pathway-in-asthmatic-mice
#1
Lishen Shan, Xinyuan Kang, Fen Liu, Xuxu Cai, Xiaohua Han, Yunxiao Shang
The present study aimed to investigate the effect of epigallocatechin gallate (EGCG) on airway inflammation in mice with bronchial asthma, and the regulatory mechanism of transforming growth factor (TGF)‑β1 signaling pathway, so as to provide theoretical basis for research and development of a novel drug for clinical treatment. Mouse models of bronchial asthma were established and injected with dexamethasone and EGCG via the caudal vein. 7 days later, bronchoalveolar tissue was collected for hematoxylin and eosin staining...
June 18, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29909073/changes-in-the-breath-sound-spectrum-with-bronchodilation-in-children-with-asthma
#2
Mariko Nukaga, Hideyuki Tabata, Mayumi Enseki, Kota Hirai, Hiroyuki Furuya, Masahiko Kato, Hiroyuki Mochizuki
BACKGROUND: Breath sound parameters have been suggested to be new biomarkers of airway function in patients with asthma. METHODS: We investigated the effect of bronchodilation on breath sound parameters in sixty-four children (mean age, 8.9 years; range, 6-16 years) using a breath sound analyzer. The breath sound parameters included frequency limiting 50% and 99% of the power spectrum (F50 and F99 ), roll-off from 600-1200 Hz (slope), and spectrum curve indices such as the ratios of the third and fourth power area to the total area of the power spectrum (P3 /PT and P4 /PT ), total area under the curve (A3 /AT and B4 /AT ), and the ratio of power and frequency at 50% and 75% of the highest frequency of the power spectrum (RPF75 and RPF50 )...
June 13, 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29909018/successful-treatment-of-eosinophilic-otitis-media-associated-with-severe-bronchial-asthma-with-an-anti-il-5-monoclonal-antibody-mepolizumab
#3
Isao Suzaki, Yurika Kimura, Akihiko Tanaka, Kojiro Hirano, Atsushi Ishibashi, Tomomi Mizuyoshi, Izumi Ando, Tatsuya Kitajima, So Watanabe, Yasuyuki Hinonira, Hitome Kobayashi
Eosinophilic otitis media (EOM), which is characterized by the accumulation of eosinophils in middle ear effusion and the middle ear mucosa, is a refractory type of otitis media that is often associated with asthma. Although an early diagnosis and appropriate treatment are necessary to prevent the progression of hearing loss in patients with EOM, there are currently no well-established treatments for this condition. We treated a 60-year-old male patient with asthma and EOM. The patient's asthma was poorly controlled, despite the use of high-dose inhaled corticosteroids, long-acting beta-agonist treatment, and the regular use of systemic corticosteroids...
June 13, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29908291/tumor-necrosis-factor-%C3%AE-interleukin-8-and-eosinophil-cationic-protein-as-serum-markers-of-glucocorticoid-efficacy-in-the-treatment-of-bronchial-asthma
#4
Jing Ren, Yong Sun, Gang Li, Xiao-Jue Zhu, Jin-Guo Cui
BACKGROUND: Bronchial asthma (BA) is a common chronic respiratory disease that has exhibited a rising global incidence in recent years. Glucocorticoids are used for the treatment of BA. Emerging evidence has demonstrated the roles of tumor necrosis factor (TNF-α), interleukin-8 (IL-8) and eosinophil cationic protein (ECP) in BA. The present study investigated whether TNF-α, IL-8 and ECP were associated with the clinical stages and severity of BA and the efficacy of glucocorticoids in the treatment of BA...
June 13, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29908086/innate-immune-response-reflects-disease-activity-in-eosinophilic-granulomatosis-with-polyangiitis
#5
Naomi Tsurikisawa, Chiyako Oshikata, Maiko Watanabe, Takahiro Tsuburai, Takeshi Kaneko, Hiroshi Saito
BACKGROUND: Eosinophilic granulomatosis with polyangiitis (EGPA) is a disease characterized by allergic granulomatosis, necrotizing vasculitis, and peripheral blood eosinophilia. Interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and type-2 innate lymphoid cells (ILC2) are involved in the innate and type-2 immune responses in EGPA. However, the relationships among these molecules and the mechanisms underlying the development of EGPA remain unknown. OBJECTIVE: We investigated the relationships among peripheral blood eosinophil count, serum IL-33 and TSLP concentration, and peripheral blood ILC2 count in patients with EGPA, chronic eosinophilic pneumonia (CEP), or bronchial asthma (BA)...
June 16, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29907668/longterm-outcomes-of-188-japanese-patients-with-eosinophilic-granulomatosis-with-polyangiitis
#6
Aiko Saku, Shunsuke Furuta, Masaki Hiraguri, Kei Ikeda, Yoshihisa Kobayashi, Shin-Ichiro Kagami, Kazuhiro Kurasawa, Ryutaro Matsumura, Daiki Nakagomi, Takao Sugiyama, Takeshi Umibe, Norihiko Watanabe, Hiroshi Nakajima
OBJECTIVE: Patients with eosinophilic granulomatosis with polyangiitis (EGPA) frequently experience relapses, which lead to cumulative organ damage. In this retrospective observational study, we aimed to reveal the risk factors for relapse in EGPA. METHODS: A total of 188 Japanese patients with EGPA diagnosed between 1996 and 2015 were identified from medical records in 10 hospitals. The diagnosis was based on the American College of Rheumatology 1990 criteria or Lanham's criteria...
June 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29906536/mahuang-decoction-mitigates-airway-inflammation-and-regulates-il-21-stat3-signaling-pathway-in-rat-asthma-model
#7
Yu He, Xiaohui Lou, Zhan Jin, Li Yu, Ling Deng, Haitong Wan
ETHNOPHARMACOLOGICAL RELEVANCE: Nowadays, bronchial asthma is still a severe disease threatening human health, and it is incumbent upon us to seek effective therapeutic drugs. Mahuang decoction (MHD), a classic famous Chinese prescription, has been used for thousands of years to prevent phlegm from forming, stop coughing and relieve asthma, but the relevant mechanism has not been thoroughly clarified. This study aims to investigate the anti-airway inflammation effect of MHD and the possible molecular mechanism underlying IL21/STAT3 signaling pathway, so as to provide guidance for the treatment of MHD on bronchial asthma...
June 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29905356/-biologics-in-rhinology-forthcoming-personalized-concepts-the-future-starts-today
#8
Adam M Chaker
Sinunasale Erkrankungen zählen mit zu den häufigsten chronischen Erkrankungen und führen zu einer erheblichen Störung der Lebensqualität, ein komorbides Asthma ist häufig. Trotz leitliniengerechter Therapie ist anzunehmen, dass mind. 20% der Patienten ihre Erkrankungssymptome nicht adäquat kontrollieren können. Neben den etablierten chirurgischen und konservativen Therapieoptionen finden sich nun vielversprechende Therapieansätze, die bspw. mittels therapeutischer Antikörper mechanistisch gezielt in die Pathophysiologie der Erkrankungen eingreifen können...
March 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29904594/towards-precision-medicine-the-application-of-omics-technologies-in-asthma-management
#9
Chiara Scelfo, Carla Galeone, Francesca Bertolini, Marco Caminati, Patrizia Ruggiero, Nicola Facciolongo, Francesco Menzella
Asthma is a chronic obstructive respiratory disease characterised by bronchial inflammation. Its biological and clinical features have been widely explored and a number of pharmacological treatments are currently available. Currently several aspects of asthma pathophysiological background remain unclear, and this is crucial for the traditional asthma phenotype approach as well as for new endotype definition. In this scenario, the identification of new molecular and clinical biomarkers may be helpful in order to better understand the disease, define specific diagnostic tools and highlight relevant novel targets for pharmacology treatments...
2018: F1000Research
https://www.readbyqxmd.com/read/29902480/epithelial-il-6-trans-signaling-defines-a-new-asthma-phenotype-with-increased-airway-inflammation
#10
Zala Jevnikar, Jörgen Östling, Elisabeth Ax, Jenny Calvén, Kristofer Thörn, Elisabeth Israelsson, Lisa Öberg, Akul Singhania, Laurie C K Lau, Susan J Wilson, Jonathan A Ward, Anoop Chauhan, Ana R Sousa, Bertrand De Meulder, Matthew J Loza, Frédéric Baribaud, Peter J Sterk, Kian Fan Chung, Kai Sun, Yike Guo, Ian M Adcock, Debbie Payne, Barbro Dahlen, Pascal Chanez, Dominick E Shaw, Norbert Krug, Jens M Hohlfeld, Thomas Sandström, Ratko Djukanovic, Anna James, Timothy S C Hinks, Peter H Howarth, Outi Vaarala, Marleen van Geest, Henric K Olsson
BACKGROUND: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) with asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in asthma is unclear. OBJECTIVE: To explore the association between epithelial IL-6TS pathway activation and molecular and clinical phenotypes in asthma. METHODS: An IL-6TS gene signature, obtained from air-liquid interface (ALI) cultures of human bronchial epithelial cells stimulated with IL-6 and sIL-6R, was used to stratify lung epithelium transcriptomic data (U-BIOPRED cohorts) by hierarchical clustering...
June 11, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29901144/expression-of-vitamin-d-receptor-in-bronchial-asthma-and-its-bioinformatics-prediction
#11
Lishen Shan, Xinyuan Kang, Fen Liu, Xuxu Cai, Xiaohua Han, Yunxiao Shang
Vitamin D receptors (VDRs) are associated with the occurrence and development of asthma. The aim of the present study was to analyze the secondary structure and B‑cell and T‑cell epitopes of VDR using online prediction software and aid in the future development of a highly efficient epitope‑based vaccine against asthma. Blood samples were collected from peripheral blood of asthmatic children. Reverse transcription quantitative‑polymerase chain reaction (RT‑qPCR) was performed to detect the expression of VDR in the peripheral blood...
June 13, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29896220/effects-of-ozone-stimulation-of-bronchial-epithelial-cells-on-proliferation-and-collagen-synthesis-of-co-cultured-lung-fibroblasts
#12
Yue Wang, Meiling Tan, Haiping Ouyang, Linhong Deng
Ozone (O3 ) as a major air pollutant is widely recognized for causing pathological changes of the airway system. However, it is not clear whether O3 exposure of bronchial epithelial cells (BECs) influences the proliferation and collagen synthesis of submucosal fibroblasts and contributes to the pathogenesis of airway remodeling in diseases, including asthma. In the present study, a co-culture method was applied to culture human lung fibroblasts (HLFs) with human bronchial epithelial cells (HBECs) that were pre-stimulated with O3 ...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29892540/black-lungs-and-big-nodes-a-case-of-airway-anthracosis-with-bronchial-anthracofibrosis
#13
S R Devarajan, N Zarrin-Khameh, P Alapat
We present a case of a 76 year-old, non-smoking Honduran female who was referred to our clinic for years of persistent dry cough. Cardiac evaluation was unremarkable. She denied symptoms of heartburn, allergic rhinitis, and there was no personal or family history of asthma. Her physical exam demonstrated wheezing over the right mid-posterior chest. Spirometry was within normal limits. CT-imaging of the chest demonstrated right middle lobe bronchus and lingular segmental bronchus narrowing with bibasilar atelectasis and mild interlobular septal thickening with prominent mediastinal adenopathy...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29892153/eosinophilic-granulomatosis-with-polyangiitis-manifested-by-cholecystitis-and-mononeuritis-multiplex-a-case-report
#14
Maryam Mobini, Hamed Cheraghmakani, Zhila Torabizadeh, Omid Emadian, Fatemeh Nezhadi Kelarijani
Eosinophilic granulomatosis with polyangiitis formerly named "Churg-Strauss syndrome (CSS)" is a systemic disease with bronchial asthma, hypereosinophilia, and systemic vasculitis. We report a case of CSS with cholecystitis and mononeuritis multiplex. A 50-year-old woman with a history of sinusitis and bronchial asthma of 8 years' duration was referred with a complaint of left-hand deformity and difficulty in walking. The laboratory findings included remarkable eosinophilia, an elevated erythrocyte sedimentation rate, and a marked eosinophilic infiltration in the gallbladder biopsy...
May 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29890236/a-bispecific-antibody-strategy-to-target-multiple-type-2-cytokines-in-asthma
#15
Marie Godar, Kim Deswarte, Karl Vergote, Michael Saunders, Hans de Haard, Hamida Hammad, Christophe Blanchetot, Bart N Lambrecht
BACKGROUND: Asthma is a chronic inflammatory airway disease in which innate and adaptive immune cells act together to cause eosinophilic inflammation, goblet cell metaplasia (GCM) and bronchial hyperreactivity (BHR). In clinical trials employing biologicals against interleukin (IL)-4Rα or IL-5, only a subset of moderate-to-severe asthmatics responded favorably, suggesting that distinct pathophysiological mechanisms are at play in subgroups of patients, called endotypes. However, the effect of multiple cytokine blockade using bispecific antibodies (Ab) has not been tested...
June 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29887979/determinants-of-persistent-asthma-in-young-adults
#16
Lisbet Krogh Traulsen, Anders Halling, Jesper Bælum, Jesper Rømhild Davidsen, Martin Miller, Øyvind Omland, David Sherson, Torben Sigsgaard, Trine Thilsing, Gert Thomsen, Lars Rauff Skadhauge
Objective: The aim of the study was to evaluate determinants for the prognosis of asthma in a population-based cohort of young adults. Design: The study was a nine-year clinical follow up of 239 asthmatic subjects from an enriched population-based sample of 1,191 young adults, aged 20-44 years, who participated in an interviewer-administered questionnaire and clinical examination at baseline in 2003-2006. From the interview, an asthma score was generated as the simple sum of affirmative answers to five main asthma-like symptoms in order to analyse symptoms of asthma as a continuum...
2018: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29886267/clinical-phenotypes-of-bronchial-hyperresponsiveness-in-school-aged-children
#17
Eun Lee, Young-Ho Kim, Hyun-Ju Cho, Ji-Sun Yoon, Sungsu Jung, Song-I Yang, Hyung Young Kim, Ji-Won Kwon, Ju-Hee Seo, Hyo Bin Kim, So Yeon Lee, Soo-Jong Hong
BACKGROUND: Bronchial hyperresponsiveness (BHR), one of the key features of asthma, shows a diverse natural course in school-aged children, but, studies on BHR phenotypes are lacking. OBJECTIVE: We classified BHR phenotypes according to onset age and persistence in children and investigated the characteristics and factors associated with each phenotype in a longitudinal study. METHODS: We analyzed 1,305 elementary school children from the Children's HEalth and Environmental Research (CHEER) study, a 4-year prospective follow-up study with 2-year intervals starting at a mean age of 7 years...
June 7, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29885665/bacterial-biogeography-of-adult-airways-in-atopic-asthma
#18
Juliana Durack, Yvonne J Huang, Snehal Nariya, Laura S Christian, K Mark Ansel, Avraham Beigelman, Mario Castro, Anne-Marie Dyer, Elliot Israel, Monica Kraft, Richard J Martin, David T Mauger, Sharon R Rosenberg, Tonya S King, Steven R White, Loren C Denlinger, Fernando Holguin, Stephen C Lazarus, Njira Lugogo, Stephen P Peters, Lewis J Smith, Michael E Wechsler, Susan V Lynch, Homer A Boushey
BACKGROUND: Perturbations to the composition and function of bronchial bacterial communities appear to contribute to the pathophysiology of asthma. Unraveling the nature and mechanisms of these complex associations will require large longitudinal studies, for which bronchoscopy is poorly suited. Studies of samples obtained by sputum induction and nasopharyngeal brushing or lavage have also reported asthma-associated microbiota characteristics. It remains unknown, however, whether the microbiota detected in these less-invasive sample types reflect the composition of bronchial microbiota in asthma...
June 9, 2018: Microbiome
https://www.readbyqxmd.com/read/29879991/is-ige-or-eosinophils-the-key-player-in-allergic-asthma-pathogenesis-are-we-asking-the-right-question
#19
REVIEW
Andrea Matucci, Alessandra Vultaggio, Enrico Maggi, Ismail Kasujee
Bronchial asthma (BA) is a chronic inflammatory disease with a marked heterogeneity in pathophysiology and etiology. The heterogeneity of BA may be related to the inducing mechanism(s) (allergic vs non-allergic), the histopathological background (eosinophilic vs non-eosinophilic), and the clinical manifestations, particularly in terms of severity and frequency of exacerbations. Asthma can be divided into at least two different endotypes based on the degree of Th2 inflammation (T2 'high' and T2 'low'). For patients with severe uncontrolled asthma, monoclonal antibodies (mAbs) against immunoglobulin E (IgE) or interleukin (IL)-5 are now available as add-on treatments...
June 8, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29879314/ormdl3-and-its-implication-in-inflammatory-disorders
#20
REVIEW
Xiaochun Ma, Feng Long, Yan Yun, Jie Dang, Shijun Wei, Qian Zhang, Jinzhang Li, Haizhou Zhang, Wenlong Zhang, Zhengjun Wang, Qiji Liu, Chengwei Zou
A growing body of evidence has suggested the genetic association of ORMDL3 gene (ORMDL Sphingolipid Biosynthesis Regulator 3) polymorphisms with a diverse set of inflammatory disorders that include bronchial asthma, inflammatory bowel disease, ankylosing spondylitis and atherosclerosis. Gene functional investigations have revealed the particular relevance of ORMDL3 in endoplasmic reticulum stress, lipid metabolism and inflammatory reactions. Additionally, several reports have recently added a new dimension to our understanding of the modulation of ORMDL3 gene expression in inflammation...
June 2018: International Journal of Rheumatic Diseases
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