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Animal Allergy

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https://www.readbyqxmd.com/read/29895510/food-allergy-training-for-schools-and-restaurants-the-food-allergy-community-program-protocol-to-evaluate-the-effectiveness-of-a-web-based-program
#1
Inês Pádua, André Moreira, Pedro Moreira, Renata Barros
BACKGROUND: Food allergy is a growing public health concern. The literature suggests that a significant number of reactions occur in community services, such as schools and restaurants. Therefore, suitable training and education for education and catering professionals using viable and practical tools is needed. OBJECTIVE: The objective of this study is to evaluate the effectiveness of a Web-based food allergy training program for professionals working in schools and restaurants, designed to improve knowledge and good practices in the community...
June 12, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29893631/assessing-cat-flea-microbiomes-in-northern-and-southern-california-by-16s-rrna-next-generation-sequencing
#2
Elton J R Vasconcelos, Sarah A Billeter, Lindsey A Jett, Richard J Meinersmann, Margaret C Barr, Pedro P V P Diniz, Brian B Oakley
Flea-borne diseases (FBDs) impact both human and animal health worldwide. Because adult fleas are obligately hematophagous and can harbor potential pathogens, fleas act as ectoparasites of vertebrates, as well as zoonotic disease vectors. Cat fleas (Ctenocephalides felis) are important vectors of two zoonotic bacterial genera listed as priority pathogens by the National Institute of Allergy and Infectious Diseases (NIAID-USA): Bartonella spp. and Rickettsia spp., causative agents of bartonelloses and rickettsioses, respectively...
June 12, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29888657/oral-administration-of-bifidobacterium-bifidum-tmc3115-to-neonatal-mice-may-alleviate-ige-mediated-allergic-risk-in-adulthood
#3
R Y Cheng, J R Yao, Q Wan, J W Guo, F F Pu, L Shi, W Hu, Y H Yang, L Li, M Li, F He
This study aimed to demonstrate whether exposure to bifidobacteria during early life influences immunity and alleviates the risk of immunoglobulin E (IgE)-mediated allergies in adulthood. BALB/c neonatal mice (n=54) were administered with a lyophilised cell preparation of Bifidobacterium bifidum TMC3115 (TMC3115) for 3 weeks. Following the intervention, the mice were immunised with intraperitoneal ovalbumin (OVA). The morphology and function of the intestinal epithelium were determined using histopathological examinations...
June 11, 2018: Beneficial Microbes
https://www.readbyqxmd.com/read/29886072/study-of-the-allergenic-potential-of-bacillus-thuringiensis-cry1ac-toxin-following-intra-gastric-administration-in-a-murine-model-of-food-allergy
#4
Karla I Santos-Vigil, Damaris Ilhuicatzi-Alvarado, Ana L García-Hernández, Juan S Herrera-García, Leticia Moreno-Fierros
Cry1Ac toxin, from Bacillus thuringiensis, is widely used as a biopesticide and expressed in genetically modified (GM) plants used for human and animal consumption. Since Cry1Ac is also immunogenic and able to activate macrophages, it is crucial to thoroughly evaluate the immunological effects elicited after intra-gastric administration. The allergenic potential of purified Cry1Ac was assessed and compared with that induced in a murine model of food-allergy to ovalbumin (OVA), in which animals are sensitized with the adjuvant Cholera toxin (CT)...
June 7, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29882150/evaluating-antigen-specific-ige-using-the-rat-basophil-leukemia-cell-rbl-assay
#5
Marsha D W Ward, Lisa B Copeland
Allergic diseases (atopy) include asthma, allergic rhinitis, conjunctivitis, and allergic sinusitis. It is estimated that up to 90% of asthmatics are atopic and have an allergy trigger for asthmatic episodes. In order to assess the risk of allergy induction associated with inhalation exposure, animal models of protein allergy have been developed. These models have been used both to identify proteins as allergens and to assess their relative potency. Often these research situations include allergens that are not well characterized or are unknown...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29881542/cross-sectional-study-on-sensitization-to-mite-and-cockroach-allergen-components-in-allergy-patients-in-the-central-european-region
#6
Petr Panzner, Martina Vachová, Tomáš Vlas, Petra Vítovcová, Petra Brodská, Marek Malý
Background: The major sources of allergens in the indoor air include house dust mites, dander derived from domestic animals and rodents, cockroach, and several fungi. Mites are the main cause of allergies in some countries with a warmer climate, but the epidemiological significance of mite and cockroach allergens in Central Europe has not been established yet. Methods: We assessed sensitization profiles of allergy patients in a Central European region in regard to sensitization to mites and cockroach...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29864076/patient-reported-allergies-are-associated-with-preoperative-psychological-distress-and-less-satisfying-patient-experience-in-a-lumbar-spine-surgery-population
#7
Jay M Levin, Spencer Boyle, Robert D Winkelman, Joseph E Tanenbaum, Kalil G Abdullah, Michael P Steinmetz, Thomas E Mroz
STUDY DESIGN: This was a retrospective cohort study. OBJECTIVE: The main objectives of this study were: (1) to determine whether patient-reported allergies (PRAs) are associated with patient satisfaction scores, and (2) to clarify the association between PRAs and preoperative anxiety and depression in a lumbar spine surgery population. SUMMARY OF BACKGROUND DATA: Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey is currently used to measure the patient experience and there is concern that psychosocial factors are unaccounted for...
June 1, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29858653/biomarkers-of-respiratory-allergy-in-laboratory-animal-care-workers-an-observational-study
#8
Federica Tafuro, Luisella Selis, Matteo Goldoni, Mariarita Stendardo, Paola Mozzoni, Erminia Ridolo, Piera Boschetto, Massimo Corradi
OBJECTIVES: Laboratory animal allergy is a highly prevalent occupational disease among exposed workers. The aim of the study was to validate the biomarkers of airway inflammation in laboratory animal (LA) care workers. METHODS: All of the participants in this observational study (63 LA care workers and 64 controls) were administered a clinical questionnaire, underwent spirometry and a skin prick or radioallergosorbent test for common and occupational aeroallergens, and the fraction of exhaled nitric oxide (FeNO50 ), exhaled breath condensate hydrogen peroxide (EBC H2 O2 ) and serum pneumoprotein levels were measured...
June 1, 2018: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29858102/seafood-allergy-a-comprehensive-review-of-fish-and-shellfish-allergens
#9
Thimo Ruethers, Aya C Taki, Elecia B Johnston, Roni Nugraha, Thu T K Le, Tanja Kalic, Thomas R McLean, Sandip D Kamath, Andreas L Lopata
Seafood refers to several distinct groups of edible aquatic animals including fish, crustacean, and mollusc. The two invertebrate groups of crustacean and mollusc are, for culinary reasons, often combined as shellfish but belong to two very different phyla. The evolutionary and taxonomic diversity of the various consumed seafood species poses a challenge in the identification and characterisation of the major and minor allergens critical for reliable diagnostics and therapeutic treatments. Many allergenic proteins are very different between these groups; however, some pan-allergens, including parvalbumin, tropomyosin and arginine kinase, seem to induce immunological and clinical cross-reactivity...
May 29, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29798078/-multiple-factor-analysis-of-serum-allergen-distribution-of-patients-with-allergic-rhinitis-and-level-of-main-allergen-ige-in-shenyang-area
#10
Y L Chu, A H Yan, X H Tai, X J Jiang, L Hui, F F Jiang, Y Hu
Objective: To discuss multiple-factor analysis of serum allergen distribution of patients with allergic rhinitis and level of main allergen IgE in Shenyang area, and to provide a scientific basis for the prevention of allergic rhinitis in this area. Method: Serum IgE was detected in 749 cases[501 cases of male (66.8%), and 248 cases of female (33.2%)], with allergic rhinitis.The age range was from 3 to 65 years old, and they were divided into 5 groups based on age. A questionnaire survey was conducted to analyze the distribution of serum allergens and to carry out a multiple-factor analysis of level of the main allergen IgE in patients...
April 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29790165/igg1-b-cell-immunity-predates-ige-responses-in-epicutaneous-sensitization-to-foods
#11
Rodrigo Jiménez-Saiz, Yosef Ellenbogen, Joshua Koenig, Melissa E Gordon, Tina D Walker, Domenico Rosace, Paul Spill, Kelly Bruton, Joshua Kong, Kristin Monteiro, Jianping Wen, Elaine I Tuomanen, Roland Kolbeck, Derek K Chu, Susan Waserman, Manel Jordana
BACKGROUND: The generation of IgE-mediated food allergy in humans is silent, and only diagnosed upon manifestation of clinical symptoms. While experimental models have been used to investigate some mechanisms of allergic sensitization, the generation of humoral immunity and memory remain to be elucidated. Here, we defined the evolution of allergen-specific B cell responses during epicutaneous sensitization to foods. METHODS: Wild-type and genetic knockout animals, and drug or antibody strategies for cell depletion and immunoglobulin signaling blockade were used to investigate epicutaneous sensitization and disease progression; we analyzed allergen-specific germinal centers and IgG1+ memory B cells by flow cytometry, evaluated humoral responses and determined clinical reactivity (anaphylaxis)...
May 22, 2018: Allergy
https://www.readbyqxmd.com/read/29787795/anti-allergy-and-anti-tussive-activity-of-clitoria-ternatea-l-in-experimental-animals
#12
Niraj Kumar Singh, Debapriya Garabadu, Priyanka Sharma, Sushant Kumar Shrivastava, Pradeep Mishra
ETHNOPHARMACOLOGICAL RELEVANCE: Clitoria ternatea flower is traditionally used in the treatment of respiratory disorders including bronchitis and is one of the ingredients in different Ayurvedic preparations that are used in respiratory disorders. However, till date there is no scientific report on the anti-asthmatic activity of this flower. AIM OF THE STUDY: Ethanolic extract of Clitoria ternatea flowers (ECT) was evaluated for its anti-allergy and anti-tussive potential in experimental animals...
May 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29779209/gata3-hypermethylation-and-foxp3-hypomethylation-are-associated-with-sustained-protection-and-bystander-effect-following-epicutaneous-immunotherapy-in-peanut-sensitized-mice
#13
Lucie Mondoulet, Vincent Dioszeghy, Florence Busato, Camille Plaquet, Véronique Dhelft, Kevin Bethune, Laurence Leclere, Christian Daviaud, Mélanie Ligouis, Hugh Sampson, Christophe Dupont, Jörg Tost
BACKGROUND: Epicutaneous immunotherapy (EPIT) is a promising method for treating food allergies. In animal models, EPIT induces sustained unresponsiveness and prevents further sensitization mediated by Tregs. Here, we elucidate the mechanisms underlying the therapeutic effect of EPIT, by characterizing the kinetics of DNA methylation changes in sorted cells from spleen and blood and by evaluating its persistence and bystander effect compared to oral immunotherapy (OIT). METHODS: BALB/c mice orally sensitized to peanut proteins (PPE) were treated by EPIT using a PPE-patch or by PPE-OIT...
May 19, 2018: Allergy
https://www.readbyqxmd.com/read/29732975/demystifying-dysbiosis-can-the-gut-microbiome-promote-oral-tolerance-over-ige-mediated-food-allergy
#14
Tom Marrs, K Sim
The growing burden of food allergy is being driven by environmental exposures and the potential role of gut micro-organisms (or 'microbiota') is hotly debated. Early culture-based studies outlined that imbalances between commensal gut constituents ('dysbiosis') early in life may raise the risk of developing allergic disease. A number of studies using animal models describe mechanisms by which specific bacterial taxa within the gut microbiota, their diversity and dietary substrates such as fibre may promote oral tolerance...
May 7, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29732293/skin-prick-test-reactivity-to-aeroallergens-in-adult-allergy-clinic-in-thailand-a-12-year-retrospective-study
#15
Supa Oncham, Umaporn Udomsubpayakul, Wannada Laisuan
Background: The global prevalence of allergic rhinitis, asthma, and atopic dermatitis has risen significantly over the last 2 decades. Allergic sensitization to aeroallergen is a major risk factor in developing the allergic disease. The prevalence of aeroallergen sensitization varies in different regions and countries. Objective: To determine the prevalence of common aeroallergen sensitization and the atopic status among adult patients. Methods: A cross-sectional, retrospective study...
April 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29726087/asthma-and-allergic-rhinitis-associate-with-the-rs2229542-variant-that-induces-a-p-lys90glu-mutation-and-compromises-akr1b1-protein-levels
#16
Elena García-Martín, Francisco J Sánchez-Gómez, Gemma Amo, Jesús García Menaya, Concepción Cordobés, Pedro Ayuso, M Carmen Plaza Serón, Miguel Blanca, Paloma Campo, Gara Esguevillas, María A Pajares, José A G Agúndez, Dolores Pérez-Sala
Asthma and rhinitis are two of the main clinical manifestations of allergy, in which increased reactive oxygen or electrophilic species can play a pathogenic role. Aldose reductase (AKR1B1) is involved in aldehyde detoxification and redox balance. Recent evidence from animal models points to a role of AKR1B1 in asthma and rhinitis, but its involvement in human allergy has not been addressed. Here, the putative association of allergic rhinitis and asthma with AKR1B1 variants has been explored by analysis of single-strand variants on the AKR1B1 gene sequence in 526 healthy subjects and 515 patients with allergic rhinitis, 366 of whom also had asthma...
May 3, 2018: Human Mutation
https://www.readbyqxmd.com/read/29719717/consideration-of-methods-for-identifying-mite-allergens
#17
REVIEW
Yubao Cui, Qiong Wang, Haoyuan Jia
House dust mites are small arthropods that produce proteins-found in their feces, body parts, and eggs-that are major triggers of human allergies worldwide. The goal of this review is to describe the current methods used to identify these allergens. A literature search for allergen identification methods employed between 1995 and 2016 revealed multiple techniques that can be broadly grouped into discovery and confirmation phases. The discovery phase employs screening for mite proteins that can bind IgEs in sera from animals or patients allergic to dust mites...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29715467/diversity-of-peptidic-and-proteinaceous-toxins-from-social-hymenoptera-venoms
#18
José Roberto Aparecido Dos Santos-Pinto, Amilcar Perez-Riverol, Alexis Musacchio Lasa, Mario Sergio Palma
Among venomous animals, Hymenoptera have been suggested as a rich source of natural toxins. Due to their broad ecological diversity, venom from Hymenoptera insects (bees, wasps and ants) have evolved differentially thus widening the types and biological functions of their components. To date, insect toxinology analysis have scarcely uncovered the complex composition of bee, wasp and ant venoms which include low molecular weight compounds, highly abundant peptides and proteins, including several allergens. In Hymenoptera, these complex mixtures of toxins represent a potent arsenal of biological weapons that are used for self-defense, to repel intruders and to capture prey...
April 28, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29707474/vitamin-a-and-d-in-allergy-from-experimental-animal-models-and-cellular-studies-to-human-disease
#19
REVIEW
Karin Hufnagl, Erika Jensen-Jarolim
Introduction: Vitamins A and D are able to modulate innate and adaptive immune responses and may therefore influence the development and the course of allergic diseases. Materials and methods: This article reviews the current evidence for the experimental effects of vitamins A and D in vivo in animal models and on immune cells in vitro , and discusses their translational implication. A systematic literature search over the last 10 years was performed using MEDLINE and PubMed databases...
2018: Allergo Journal International
https://www.readbyqxmd.com/read/29700869/tree-nut-allergies-allergen-homology-cross-reactivity-and-implications-for-therapy
#20
Johanna M Smeekens, Kenneth Bagley, Michael Kulis
Tree nut allergy is a potentially life-threatening disease that is increasing in prevalence, now affecting 1% of the general population in the United States. While other food allergies often resolve spontaneously, tree nut allergies are outgrown in less than 10% of cases. Due to the likelihood of cross-sensitization to multiple tree nut allergens, the current treatment guideline is strict avoidance of all nuts once one tree nut allergy has been diagnosed. For example, walnut and pecan are highly cross-reactive, along with cashew and pistachio, but the extent of clinical, IgE-mediated cross-reactivity among other tree nuts remains unclear, therefore making avoidance of all tree nuts a safe approach...
April 27, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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