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Animal Allergy

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https://www.readbyqxmd.com/read/29675865/allergen-immunotherapy-in-people-dogs-cats-and-horses-differences-similarities-and-research-needs
#1
R S Mueller, E Jensen-Jarolim, F Roth-Walter, E Marti, J Janda, A A Seida, D DeBoer
In human patients with seasonal allergic rhinoconjunctivitis sensitized to grass pollen, the first successful allergen immunotherapy (AIT) was reported in 1911. Today, immunotherapy is an accepted treatment for allergic asthma, allergic rhinitis and hypersensitivities to insect venom. AIT is also used for atopic dermatitis and recently for food allergy. Subcutaneous, epicutaneous, intralymphatic, oral and sublingual protocols of AIT exist. In animals, most data are available in dogs where subcutaneous AIT is an accepted treatment for atopic dermatitis...
April 19, 2018: Allergy
https://www.readbyqxmd.com/read/29655584/nanoemulsion-adjuvant-driven-redirection-of-t-h-2-immunity-inhibits-allergic-reactions-in-murine-models-of-peanut-allergy
#2
Jessica J O'Konek, Jeffrey J Landers, Katarzyna W Janczak, Rishi R Goel, Anna M Mondrusov, Pamela T Wong, James R Baker
BACKGROUND: Immunotherapy for food allergies involves progressive increased exposures to food that result in desensitization to food allergens in some subjects but not tolerance to the food. Therefore new approaches to suppress allergic immunity to food are necessary. Previously, we demonstrated that intranasal immunization with a nanoemulsion (NE) adjuvant induces robust mucosal antibody and TH 17-polarized immunity, as well as systemic TH 1-biased cellular immunity with suppression of pre-existing TH 2-biased immunity...
April 11, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29655522/antibiotics-as-instigators-of-microbial-dysbiosis-implications-for-asthma-and-allergy
#3
REVIEW
Tomasz P Wypych, Benjamin J Marsland
The human body and its resident microbiota form a complex ecosystem, shaped by both inherited and environmental factors. The use of antibiotics represents an extreme example of environmental pressure and can broadly disrupt the microbial landscape. The benefits that antibiotics have brought to modern medicine are unquestionable; however, their overuse comes with consequences, including the potential for secondary infections by opportunistic pathogens and the spread of antibiotic resistance. Here, we discuss the implications of microbial dysbiosis driven by antibiotics, with a focus on potential links with allergy and asthma...
March 14, 2018: Trends in Immunology
https://www.readbyqxmd.com/read/29629624/identification-of-the-7s-and-11s-globulins-as-percutaneously-sensitizing-soybean-allergens-as-demonstrated-through-epidermal-application-of-crude-soybean-extract
#4
Hiroki Murakami, Takashi Ogawa, Akiho Takafuta, Erika Yano, Nobuhiro Zaima, Tatsuya Moriyama
Cutaneous exposure to food allergens can predispose individuals to food allergies. Soybean, a major allergenic food, is an ingredient in various cosmetic products. However, the types of soybean proteins that are percutaneously sensitizing in humans or animal models remain unknown. In this study, BALB/c mice were dorsally shaved and epicutaneously exposed to a crude soybean extract including sodium dodecyl sulfate or distilled water alone. Specific IgEs secreted in response to 7S globulin (Gly m 5), 11S globulin (Gly m 6), Gly m 3, and Gly m 4 were measured using enzyme-linked immunosorbent assays or immunoblots...
April 8, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29617398/impact-of-an-animal-assisted-therapy-programme-on-physiological-and-psychosocial-variables-of-paediatric-oncology-patients
#5
Nathiana B Silva, Flávia L Osório
The objective of this study was to propose an intervention and safety protocol for performing animal-assisted therapy (AAT) and evaluating its efficacy in children under outpatient oncological treatment based on psychological, physiological, and quality of life indicators for the children and caregivers. The sample consisted of 24 children diagnosed with leukaemia and solid tumours (58% girls with a mean age of 8.0 years) who underwent an AAT programme consisting of three 30-min sessions in an open group. Two dogs (one Labrador retriever and one golden retriever) were used, and activities such as sensory stimulation, gait training, and socialization were conducted...
2018: PloS One
https://www.readbyqxmd.com/read/29611236/ifn%C3%AE-inhibits-the-development-of-allergen-tolerance-and-is-conducive-to-the-development-of-asthma-on-subsequent-allergen-exposure
#6
Vanessa S Fear, Matthew W-P Poh, Shelley Gorman, Jason C Waithman, Mark W Fear
Asthma is a chronic disease affecting up to 10% of the Australian population for which medical treatment is solely aimed at relief of symptoms rather than prevention of disease. Evidence from animal and human studies demonstrates a strong link between viral respiratory infections, atopy and the development of asthma. Type I IFNs include IFNα and IFNβ, with subtype expression tailored toward the specific viral infection. We hypothesized that exposure to Type I IFNs and allergen may interfere with the healthy response to innocuous airway antigen exposure...
April 2, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29588153/furaltadone-suppresses-ige-mediated-allergic-response-through-the-inhibition-of-lyn-syk-pathway-in-mast-cells
#7
Seung Taek Nam, Hyun Woo Kim, Hyuk Soon Kim, Young Hwan Park, Dajeong Lee, Min Beom Lee, Keun Young Moon, Young Mi Kim, Wahn Soo Choi
Mast cells are critical cells that prompt various allergic response-inducing factors, contributing to allergic diseases. While used as an antibiotic for livestock, there is no study on the effect of furaltadone on allergic response. This study investigated the effect of furaltadone on mast cells and passive cutaneous anaphylaxis (PCA). Furaltadone inhibited the degranulation of mast cells stimulated by antigen (IC50 , ~3.9μM), and also suppressed the production of tumor necrosis factor (TNF)-α and interleukin (IL)-4 in a concentration dependent manner...
March 24, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29576801/antibacterial-effects-of-leaf-extract-of-nandina-domestica-and-the-underlined-mechanism
#8
Zhao-Yu Guo, Zhuo-Yang Zhang, Jia-Qi Xiao, Jin-Hong Qin, Wei Zhao
Aim: The study was conducted to investigate the antibacterial and antiasthmatic effects of Nandina domestica leaf extract, to find out its active components, and to assess its safety issue. Methods: (1) Solid-phase agar dilution method was used for antibacterial activity test of nandina leaf extract and the change of bacterial morphology after treatment was observed under the transmission microscope; (2) guinea pig model of asthma was used to test the asthma prevention effect of nandina leaf extract; (3) alkaloids and flavones were separated from nandina leaf extract and were further analyzed with HPLC-MS; (4) mice model was used to assessment of the safety issue of nandina leaf extract...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29575179/sensitisation-to-minor-cat-allergen-components-is-associated-with-type-2-biomarkers-in-young-asthmatics
#9
N Tsolakis, A Malinovschi, L Nordvall, L Mattsson, J Lidholm, C Pedroletti, C Janson, M P Borres, K Alving
BACKGROUND: Cat allergy is a major trigger of asthma worldwide. Molecular patterns of cat sensitisation vary between individuals, but their relationship to inflammation in asthmatics has not been extensively studied. OBJECTIVE: To investigate the prevalence and levels of IgE antibodies against different cat allergen components and their relationship to type-2 inflammation and total IgE among young asthmatic subjects sensitised to furry animals. METHODS: Patients with asthma (age 10-35 years; n=266) and IgE sensitisation to cat, dog or horse extract (ImmunoCAP), were analysed for IgE to the cat allergen components Fel d 1 (secretoglobin), Fel d 2 (serum albumin), Fel d 4 and Fel d 7 (lipocalins)...
March 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29574759/humanizing-the-mouse-immune-system-to-study-splanchnic-organ-inflammation
#10
Brianyell McDaniel, Matthew B Grisham
It is well known that alterations in splanchnic organ perfusion and/or immune regulation may produce inflammatory tissue injury similar to that observed in several human disorders such as ischemia and reperfusion injury, food allergies, diabetes, inflammatory bowel disease and graft-versus-host disease. Mouse models have been tremendously important in defining the roles of the circulation, leukocyte trafficking, inflammatory mediator generation, immune regulation and the intestinal microbiota in the pathogenesis of acute and chronic inflammation...
March 24, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29569338/gorilla-endoscopic-sinus-surgery-a-life-saving-collaboration-between-human-and-veterinary-medicine
#11
Greg E Davis, Fred M Baik, Robert M Liddell, Andrew G Ayars, Kelley R Branch, Paul S Pottinger, Allen D Hillel, Kelly Helmick, Darin Collins
BACKGROUND: Chronic rhinosinusitis is a common disease process in humans; however, in the primate population of gorillas, it has rarely been described. This case describes lifesaving sinus surgery on a critically ill gorilla performed by a human otolaryngology team in collaboration with the gorilla's veterinary medicine team. METHODS: The 35-year-old western silverback gorilla was treated for 3 months with aggressive medical therapy for a worsening sinus infection...
March 23, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29538537/factors-associated-with-asthma-expression-in-adolescents
#12
Silvia de Souza Campos Fernandes, Dirceu Solé, Paulo Camargos, Cláudia Ribeiro de Andrade, Cássio da Cunha Ibiapina
OBJECTIVE: To evaluate risk factors associated with asthma symptoms in adolescents in the 13- to 14-year age bracket. METHODS: This was a cross-sectional study involving adolescents enrolled in randomly selected public schools in the city of Belo Horizonte, Brazil, and conducted with the use of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and its supplementary module for risk factor assessment. The ISAAC questionnaire was completed by the students themselves, whereas the supplementary questionnaire was completed by their parents or legal guardians...
January 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29533130/reply-to-the-letter-to-the-editor-concerning-the-review-immunotherapy-for-pet-allergies
#13
Tuomas Virtanen
In animal allergy, component resolved diagnosis can be valuable in identifying the primary sensitizer. The nature of dog allergens may contribute to the outcome of allergen immunotherapy in dog allergy.
March 13, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29532852/inhibitory-effects-of-bee-venom-on-mast-cell-mediated-allergic-inflammatory-responses
#14
Yun-Mi Kang, Kyung-Sook Chung, In-Hoon Kook, Yoon-Bum Kook, Hyunsu Bae, Minho Lee, Hyo-Jin An
Although bee venom (BV) is a toxin that causes bee stings to be painful, it has been widely used clinically for the treatment of certain immune‑associated diseases. BV has been used traditionally for the treatment of chronic inflammatory diseases. In this regard, the present study analyzed the effect of BV on the regulation of inflammatory mediator production by mast cells and their allergic inflammatory responses in an animal model. HMC‑1 cells were treated with BV prior to stimulation with phorbol‑12‑myristate 13‑acetate plus calcium ionophore A23187 (PMACI)...
March 12, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29518474/anti-allergy-activities-of-kuji-amber-extract-and-kujigamberol
#15
Miku Maruyama, Miki Kobayashi, Takeshi Uchida, Eisaku Shimizu, Hironori Higashio, Misa Ohno, Shota Uesugi, Ken-Ichi Kimura
Amber is fossilized tree resin and several biologically active compounds were isolated from ambers using the growth-restoring activity of the mutant yeast [Saccharomyces cerevisiae (zds1∆ erg3∆ pdr1∆ pdr3∆)] involving Ca2+ -signal transduction. The aim of this study is to investigate the anti-allergic effect of both the methanol extract of Kuji amber (MEKA) and its main biologically active constituent, kujigamberol (15,20-dinor-5,7,9-labdatrien-18-ol) having activity against the mutant yeast. Both MEKA and kujigamberol inhibited the degranulation of RBL-2H3 cells by stimulation of thapsigargin (Tg) (IC50  = 15...
March 5, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29515571/nanoparticles-for-the-induction-of-antigen-specific-immunological-tolerance
#16
REVIEW
Takashi Kei Kishimoto, Roberto A Maldonado
Antigen-specific immune tolerance has been a long-standing goal for immunotherapy for the treatment of autoimmune diseases and allergies and for the prevention of allograft rejection and anti-drug antibodies directed against biologic therapies. Nanoparticles have emerged as powerful tools to initiate and modulate immune responses due to their inherent capacity to target antigen-presenting cells (APCs) and deliver coordinated signals that can elicit an antigen-specific immune response. A wide range of strategies have been described to create tolerogenic nanoparticles (tNPs) that fall into three broad categories...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29502069/galectin-3-role-in-ocular-allergy-and-potential-as-a-predictive-biomarker
#17
Frans Eberth Costa Andrade, Mab Pereira Corrêa, Alexandre Dantas Gimenes, Myrna Serapião Dos Santos, Mauro Campos, Roger Chammas, José Álvaro Pereira Gomes, Cristiane Damas Gil
AIMS: To evaluate galectin-3 (Gal-3), a β-galactoside binding protein, as a possible biomarker in ocular allergy and further investigated the role of endogenous Gal-3 in a murine model of ovalbumin (OVA)-induced allergic conjunctivitis (AC). METHODS: Conjunctival impression cytology specimens from control and patients with severe vernal keratoconjunctivitis, treated or untreated, were used to evaluate Gal-3 expression by immunocytochemistry. To investigate the mechanism of action of Gal-3, OVA-immunised BALB/c male wild-type (WT) and Gal-3 null (Gal-3-/- ) mice were challenged with eye drops containing OVA on days 14-16 with a subset of animals pretreated with 0...
March 3, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29501249/laboratory-animal-allergy-reduction-from-2001-to-2016-an-intervention-study
#18
Francesca Larese Filon, Anna Drusian, Marcella Mauro, Corrado Negro
Exposure to laboratory animals (LA) can cause allergic sensitization and symptoms as rhinitis, conjunctivitis, asthma, anaphylaxis and dermatitis. In 2000, a program was instituted at Trieste Universities to decrease LA allergy among scientists and technicians working with animals. The aim of our study was to investigate LA allergy in workers exposed to LA from 2001 to 2016, and to verify the effects of a preventive program. Four hundred sixty seven people underwent pre-employment screening for a job with laboratory animals at Universities of Trieste consisting in a medical examination, a full respiratory and allergy anamnesis, using a standardized questionnaire, skin prick test with common and occupational allergens, and spirometry...
March 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29482894/review-of-immune-tolerance-induction-in-hemophilia-a
#19
REVIEW
S J Schep, R E G Schutgens, K Fischer, M L Boes
At first sight the bleeding disorder hemophilia A seems to have little in common with immune disorders, but immunology research intersects with other disciplines including hematology. Nowadays, the most important complication in the treatment of hemophilia A is the development of neutralizing antibodies (inhibitors) against exogenous administered factor VIII (FVIII), which occurs in approximately 30% of all patients with severe hemophilia A. This antibody response renders FVIII replacement therapy ineffective, thereby increasing the risk for uncontrollable bleeding and morbidity, decreasing quality of life and increasing healthcare costs...
February 15, 2018: Blood Reviews
https://www.readbyqxmd.com/read/29467760/microrna-regulation-of-host-immune-responses-following-fungal-exposure
#20
REVIEW
Tara L Croston, Angela R Lemons, Donald H Beezhold, Brett J Green
Fungal bioaerosols are ubiquitous in the environment and human exposure can result in a variety of health effects ranging from systemic, subcutaneous, and cutaneous infections to respiratory morbidity including allergy, asthma, and hypersensitivity pneumonitis. Recent research has focused on the role of microRNAs (miRNAs) following fungal exposure and is overlooked, yet important, group of regulators capable of influencing fungal immune responses through a variety of cellular mechanisms. These small non-coding ribose nucleic acids function to regulate gene expression at the post-transcriptional level and have been shown to participate in multiple disease pathways including cancer, heart disease, apoptosis, as well as immune responses to microbial hazards and occupational allergens...
2018: Frontiers in Immunology
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