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https://www.readbyqxmd.com/read/29777942/photomodulation-multiple-sessions-as-a-promising-preventive-therapy-for-medication-related-osteonecrosis-of-the-jaws-after-tooth-extraction-in-rats
#1
Cristian Statkievicz, Luan Felipe Toro, João Martins de Mello-Neto, Daniela Pereira de Sá, Cláudio Aparecido Casatti, João Paulo Mardegan Issa, Luciano Tavares Angelo Cintra, Juliano Milanezi de Almeida, Maria José Hitomi Nagata, Valdir Gouveia Garcia, Leticia Helena Theodoro, Edilson Ervolino
The aim of this study was to evaluate the effects of photobiomodulation (PBM) with multiple sessions of low-level laser on the alveolar repair process of rats with major risk factors for medication-related osteonecrosis of the jaws (MRONJ). Senile rats received 0.45 mL of vehicle (VEH and VEH-PBM) or 0.45 mL of 100 μg/kg zoledronate (ZOL and ZOL-PBM) administrated intraperitoneally every two days during seven weeks. After three weeks of initiation of drug treatment the first lower left molar was extracted...
May 9, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29723337/medication-related-osteonecrosis-of-the-jaw-osteoradionecrosis-and-osteomyelitis-a-comparative-histopathological-study
#2
Carlos Cesar De Antoni, Mariza Akemi Matsumoto, Andréia Aparecida da Silva, Marcos Martins Curi, Joel Ferreira Santiago Júnior, Laurindo Moacir Sassi, Camila Lopes Cardoso
It is largely known that some oral diseases can be diagnosed based upon their clinical manifestation combined with the patient's medical history and generally not depending on examination. This is the case of some bone diseases such as osteoradionecrosis of the jaw (ORNJ), osteomyelitis of the jaw (OMJ), and medication-related osteonecrosis of the jaw (MRONJ). The present study aimed to analyze the histopathological features of these specific bone diseases in order to evaluate similarities and differences. Forty-four bone specimens resected from each bone disease (22 cases of ORNJ, 6 cases of OMJ, and 16 cases of MRONJ) were analyzed by two experienced oral pathologists without prior knowledge of the diagnosis, considering bone tissue condition, inflammation, vascularization, and the presence of microorganisms...
2018: Brazilian Oral Research
https://www.readbyqxmd.com/read/29714695/the-role-of-dental-care-providers-in-the-management-of-patients-prescribed-bisphosphonates-brief-clinical-guidance
#3
Hassan H Abed, Elham N Al-Sahafi
Dental care providers are likely to see patients who take bisphosphonates for various medical conditions, including osteoporosis, bony metastatic tumors, multiple myeloma, breast cancer, and prostate cancer. Bisphosphonates accumulate in areas of high bone turnover, leading to suppression of bone turnover and the aging of keratocytes. These adverse effects predispose the maxillary and mandibular bone to development of medication-related osteonecrosis of the jaw (MRONJ), specifically among oncology patients treated with intravenous bisphosphonate therapy...
May 2018: General Dentistry
https://www.readbyqxmd.com/read/29684638/medication-related-osteonecrosis-of-the-jaw-a-survey-of-knowledge-attitudes-and-practices-among-dentists-in-the-principality-of-asturias-spain
#4
M Escobedo, L García-Consuegra, S Junquera, S Olay, G Ascani, L Junquera
INTRODUCTION: The objective of this study was to investigate the knowledge and capabilities of dentists and dental students in their last year of study in regard to risk factors of medication-related osteonecrosis of the jaw (MRONJ) in Spain. MATERIAL AND METHOD: We conducted a cross-sectional study consisting of a questionnaire survey in Asturias, Spain. The study was divided into three groups: dentists who worked for the public dental health care system (n=32), dentists who worked exclusively as private health care practitioners (n= 136), and dental students in their last year (year five) of study (n= 38)...
April 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29680992/comparison-of-mucosal-and-mucoperiosteal-wound-cover-for-the-treatment-of-medication-related-osteonecrosis-of-the-jaw-lesions-a-retrospective-cohort-study
#5
Nicola Nonnenmühlen, A Burnic, A Bartella, B Lethaus, F Gerhards, O Ristow, C Pautke, F Hölzle, T Steiner
OBJECTIVES: Actually, there is no detailed guidance on how to deal with wound closure after surgical removal of medication-related osteonecrosis of the jaw (MRONJ) lesions. This study attempts to compare the difference in outcome between the mucosal and the mucoperiosteal flap closure after surgery. PATIENTS AND METHODS: In this retrospective monocentric cohort study, patients (n = 61; 35 female/26 male) suffering from MRONJ and requiring surgical therapy at the University of Aachen between 2013 and 2015 were included...
April 22, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29680848/changes-in-dimension-of-neurovascular-canals-in-the-mandible-and-maxilla-a-radiographic-finding-in-patients-diagnosed-with-mronj
#6
D Goller-Bulut, G Özcan, F Avci
BACKGROUND: The aim of this retrospective study was to compare the morphological features of neurovascular canals and foramina of patients with medication-related osteonecrosis of the jaws (MRONJ) and healthy individuals by using cone beam computed tomography (CBCT). MATERIAL AND METHODS: The CBCT images of 58 patients under bisphosphonate therapy diagnosed with MRONJ and age gender- matched controls were retrospectively evaluated. The diameter of mandibular and nasopalatine canal and mandibular, mental and lingual foramina were measured on several sections of CBCT...
May 1, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29680775/numb-chin-syndrome-a-reflection-of-malignancy-or-a-harbinger-of-mronj-a-multicenter-experience
#7
Leonzio Fortunato, Massimo Amato, Michele Simeone, Francesco Bennardo, Selene Barone, Amerigo Giudice
INTRODUCTION: Numb chin syndrome (NCS) or mental neuropathy (MN) is a disorder characterized by sensory neuropathy on the distribution of the inferior alveolar nerve or mental nerve. The most frequent causes are of odontogenic origin (infections, wrong therapies). Other etiologies are related to primary tumor, metastasis, osteoradionecrosis and medication-related osteonecrosis of the jaw (MRONJ). The aim of this study is to highlight the clinical importance of NCS as one of the first symptoms of cancer or as consequence of drug therapy...
April 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29580668/medication-related-osteonecrosis-of-the-jaw-an-update-on-the-memorial-sloan-kettering-cancer-center-experience-and-the-role-of-premedication-dental-evaluation-in-prevention
#8
Adepitan A Owosho, See Toh Yoong Liang, Adi Z Sax, Kant Wu, SaeHee K Yom, Joseph M Huryn, Cherry L Estilo
OBJECTIVE: The aim of this study was to investigate the relationship between type of antiresorptive medication and medication-related osteonecrosis of the jaw (MRONJ) onset and the role of premedication dental evaluation (PMDE) in the prevention of MRONJ. STUDY DESIGN: Our database of patients with MRONJ was reviewed. The Kruskal-Wallis test was used to analyze the onset dose of the 3 frequent medication types associated with MRONJ. To evaluate the role of PMDE in the prevention of MRONJ, all patients on antiresorptive and/or antiangiogenic medications seen in the Dental Service of Memorial Sloan Kettering Cancer Center during a 10-year period were subclassified into 2 groups...
February 14, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29576576/successful-conservative-treatment-of-jaw-osteonecrosis-caused-by-denosumab-in-patients-with-multiple-bone-metastasis
#9
Noritaka Ohga, Jun Sato, Takuya Asaka, Masahiro Morimoto, Yutaka Yamazaki, Yoshimasa Kitagawa
We report a case of osteonecrosis of the jaw (ONJ) associated with denosumab therapy in a 62-year-old female patient being treated for bone metastases from breast cancer. Upon initial presentation at the Department of Oral Medicine, Hokkaido University Hospital, the patient's mandibular molar teeth were extracted because of severe periodontal disease. Two months later, epithelialization of the sockets was observed and treatment with anti-resorptive drugs was started for bone metastases. One year after tooth extraction, bone exposure in the right lower first molar region was observed, and stage 2 medication-related ONJ (MRONJ) was diagnosed...
2018: Journal of Oral Science
https://www.readbyqxmd.com/read/29568850/medication-related-osteonecrosis-of-the-jaw-in-osteoporotic-patients-prevention-and-management
#10
Boon Hui Chan, Ruixiang Yee, Rukshini Puvanendran, Seng Bin Ang
Osteoporosis is a major, growing healthcare issue. This is especially of concern in an ageing population like that of Singapore. Osteoporotic patients are at risk of fractures, which can result in increased morbidity and mortality. The use of antiresorptive therapy with bisphosphonates or denosumab has been proven to reduce fracture risk. However, the use of these medications has rarely been associated with the development of osteonecrosis of the jaw, a potentially debilitating condition affecting one or both jaws...
February 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29563435/meth-mouth-a-growing-epidemic-in-dentistry
#11
Andreas Pabst, Juan Carlos Castillo-Duque, Axel Mayer, Marcus Klinghuber, Richard Werkmeister
In the past two decades, the synthetic style and fashion drug "crystal meth" ("crystal", "meth"), chemically representing the crystalline form of the methamphetamine hydrochloride, has become more and more popular in the United States, in Eastern Europe, and just recently in Central and Western Europe. "Meth" is cheap, easy to synthesize and to market, and has an extremely high potential for abuse and dependence. As a strong sympathomimetic, "meth" has the potency to switch off hunger, fatigue and, pain while simultaneously increasing physical and mental performance...
October 30, 2017: Dentistry journal
https://www.readbyqxmd.com/read/29563359/fatal-bleeding-in-conjunction-with-mandibular-medication-related-osteonecrosis-of-the-jaw-mronj
#12
Taiki Suzuki, Ryo Sekiya, Yuji Hamada, Miho Takahashi, Kazunari Karakida, Haruo Sakamoto
Here, we report a case of fatal bleeding in conjunction with mandibular medicationrelated osteonecrosis of the jaw (MRONJ). A 75-year-old Japanese man was referred to our department with osteonecrosis of the jaw due to bisphosphonate (BP) for multiple bone metastases from prostate cancer. Aggressive surgical intervention was ruled out due to a poor prognosis in terms of life expectancy. Death occurred due to hemorrhagic shock resulting from massive oral bleeding caused by necrosis of the mandible. Numerous reports have suggested that jaw necrosis is induced not only by BP, but also RANKL antibody, steroids, and molecularly-targeted agents...
2018: Bulletin of Tokyo Dental College
https://www.readbyqxmd.com/read/29545079/osteonecrosis-of-the-jaw-unrelated-to-medication-or-radiotherapy
#13
REVIEW
Yusuf Gadiwalla, Vinod Patel
Osteonecrosis of the jaw (ONJ) is an increasingly common condition primarily due to the rise of medication related osteonecrosis of the jaw (MRONJ) and osteoradionecrosis (ORN). Apart from MRONJ and ORN there remains a wide and varied range of rare causes and diseases that can lead to a clinical presentation of ONJ. This article aims to highlight alternatives causes of jaw necrosis following review of the literature to aid diagnosis and treatment planning for dental and head and neck specialities.
December 28, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29480596/medication-related-osteonecrosis-of-the-jaw-surgical-or-non-surgical-treatment
#14
G Favia, A Tempesta, L Limongelli, V Crincoli, E Maiorano
Medication-related osteonecrosis of the jaw (MRONJ) is a severe side effect of antiresorptive (bisphosphonates and denosumab) and anti-angiogenic therapy used in the management of oncologic and, less frequently, osteoporotic patients. While there is good international agreement on the diagnostic and staging criteria of MRONJ and the cessation of antiresorptive/anti-angiogenic treatments, the gold standard of treatment is still controversial, in particular between non-surgical and surgical approaches. The former usually includes antiseptic mouth rinse, cyclic antibiotic therapy, low-level laser therapy and periodic dental checks; the latter consists of surgical necrotic bone removal...
March 2018: Oral Diseases
https://www.readbyqxmd.com/read/29479739/denosumab-related-osteonecrosis-of-the-jaw-following-non-surgical-periodontal-therapy-a-case-report
#15
Márcio Diniz-Freitas, Javier Fernández-Feijoo, Pedro Diz Dios, Xiana Pousa, Jacobo Limeres
INTRODUCTION: Osteonecrosis of the jaw associated with bisphosphonates is currently called medication-related osteonecrosis of the jaw (MRONJ), given that in addition to bisphosphonates, jaw osteonecrosis has been related to the administration of other antiresorptive and antiangiogenic drugs, such as denosumab, sunitinib, bevacizumab and ipilimumab. CASE PRESENTATION: A 77-year-old patient with osteoporosis treated with subcutaneous injections of denosumab at an interval of 6 months is presented...
May 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29472685/pharmacology-mronj-risk-factor
#16
D Patel, V Patel
No abstract text is available yet for this article.
February 23, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29432652/osteonecrosis-of-the-jaws-a-14-year-retrospective-survey-of-hospital-admissions
#17
K McGowan, S Ivanovski, C Acton
BACKGROUND: Osteonecrosis of the jaw (ONJ) is a serious complication of both radiation and antiresorptive therapies. This study aimed to determine how many patients have been treated for medication-related osteonecrosis of the jaws (MRONJ) and osteoradionecrosis (ORN), and whether the number of diagnoses has decreased over time with improved awareness and preventative measures. METHODS: Medical records at the Royal Brisbane and Women's Hospital, Gold Coast University Hospital and Robina Hospital were reviewed to identify patients diagnosed with MRONJ and ORN between January 2003 and May 2017...
February 12, 2018: Australian Dental Journal
https://www.readbyqxmd.com/read/29410755/influence-of-the-teaching-program-on-the-learning-in-knowledge-and-practice-of-osteonecrosis-of-the-jaws-produced-by-antireasorptives-in-dental-students-of-the-principality-of-asturias-spain
#18
Matias-Ferrán Escobedo, Luis García-Consuegra, Silvia Gay, Lorena Álvarez, Sonsoles Olay, Giuliano Ascani, Luis Junquera
Background: This study aims to evaluate the influence of changes in the teaching contents on medication-related osteonecrosis of the jaw may have on the knowledge and the capacity for practical case resolution about this pathology. Material and Methods: A cross-sectional descriptive study was conducted through a survey divided into four sections: degree of means of knowledge acquisition, habitual practice and ability to solve clinical cases. The total number of respondents (n = 225) was divided into two groups: Group A (Year 2015-2016) and Group B (Year 2016-2017)...
December 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29395991/effect-of-different-doses-and-durations-of-teriparatide-therapy-on-resolution-of-medication-related-osteonecrosis-of-the-jaw-a-randomized-controlled-preclinical-study-in-rats
#19
Mohammad Zandi, Arash Dehghan, Najmeh Zandipoor, Payam Amini, Shideh Doulati
OBJECTIVE: To evaluate the effects of different doses and durations of teriparatide therapy on MRONJ resolution in rats. SUBJECTS AND METHODS: A total of 120 rats that had been affected with MRONJ (after six weekly zoledronate injections and tooth extraction) were randomly divided into eight subgroups: 2, 10, and 20 μg/kg/day teriparatide were administered to L4, M4, and H4 for 4 weeks, and to L8, M8, and H8 for 8 weeks, respectively. C4 and C8 received saline for 4 and 8 weeks, respectively...
March 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29365278/ct-imaging-features-of-antiresorptive-agent-related-osteonecrosis-of-the-jaw-medication-related-osteonecrosis-of-the-jaw
#20
Akira Baba, Tazuko K Goto, Hiroya Ojiri, Mutsumi Takagiwa, Chiho Hiraga, Masahiro Okamura, Sho Hasegawa, Yumi Okuyama, Nobuhiro Ogino, Hideomi Yamauchi, Yuko Kobashi, Shinji Yamazoe, Yohei Munetomo, Takuji Mogami, Takeshi Nomura
OBJECTIVES: Antiresorptive agent-related osteonecrosis of the jaw (ARONJ)/medication-related osteonecrosis of the jaw (MRONJ) include both bisphosphonate-related osteonecrosis of jaw (BRONJ) and denosumab-related osteonecrosis of jaw (DRONJ). The purpose of this study is to study radiological characteristics of ARONJ/MRONJ. These imaging features may serve as one useful aid for assessing ARONJ/MRONJ. METHODS: CT scans of 74 Japanese patients, who were clinically diagnosed by inclusion criteria of ARONJ/MRONJ, obtained between April 1, 2011 and September 30, 2016, were evaluated...
February 13, 2018: Dento Maxillo Facial Radiology
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