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https://www.readbyqxmd.com/read/29332231/stage-specific-therapeutic-strategies-of-medication-related-osteonecrosis-of-the-jaws-a-systematic-review-and-meta-analysis-of-the-drug-suspension-protocol
#1
REVIEW
Luca Ramaglia, Agostino Guida, Vincenzo Iorio-Siciliano, Alessandro Cuozzo, Andrea Blasi, Anton Sculean
OBJECTIVE: The most debated topic about medication-related osteonecrosis of the jaws (MRONJ) is its therapy, as there are no definitive guidelines. The aims of this systematic review were (a) to outline the best therapeutic approach according to the stage at diagnosis and (b) to perform a meta-analysis to assess whether the drug-holiday protocol may be or not an effective method in the management of MRONJ patients. MATERIALS AND METHODS: The systematic review was performed following the PRISMA principles...
January 13, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29325851/microbial-population-changes-in-patients-with-medication-related-osteonecrosis-of-the-jaw-treated-with-systemic-antibiotics
#2
Lieselotte De Bruyn, Ruxandra Coropciuc, Wim Coucke, Constantinus Politis
OBJECTIVE: This study aimed to investigate the bacterial population in patients with medication-related osteonecrosis of the jaw (MRONJ) after treatment with doxycycline and metronidazole. STUDY DESIGN: A total of 38 patients with MRONJ (age range 55-88, mean age 73 + 8.82 standard deviation) treated with doxycycline first and with metronidazole second were enrolled in this study. Two swabs were taken at the margin of the infected MRONJ lesion after applying pressure on the marginal mucosa, and visible pus was secreted...
December 11, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29289789/zoledronic-acid-increases-the-prevalence-of-medication-related-osteonecrosis-of-the-jaw-in-a-dose-dependent-manner-in-rice-rats-oryzomys-palustris-with-localized-periodontitis
#3
J G Messer, J L Mendieta Calle, J M Jiron, E J Castillo, C Van Poznak, N Bhattacharyya, D B Kimmel, J I Aguirre
OBJECTIVE: Investigate role of dose/duration of zoledronic acid (ZOL), a powerful anti-resorptive (pAR), on prevalence of medication-related osteonecrosis of the jaw (MRONJ) in rice rats (Oryzomys palustris), a species with natural susceptibility to food impaction-induced localized periodontitis (FILP). We hypothesize that ZOL induces MRONJ lesions in rice rats with FILP, and that the prevalence of MRONJ rises with increasing dose and duration of ZOL treatment. METHODS: We performed a toxicology experiment with clinically-relevant doses of ZOL in female rats (N=230) fed standard (STD) rodent chow...
December 28, 2017: Bone
https://www.readbyqxmd.com/read/29279671/dental-students-knowledge-of-medication-related-osteonecrosis-of-the-jaw
#4
Daniele Rosella, Piero Papi, Giorgio Pompa, Mario Capogreco, Francesca De Angelis, Stefano Di Carlo
Objectives: The aim of this study was to evaluate and assess knowledge and attitude of dental students about medication-related osteonecrosis of the jaw (MRONJ), to optimize future training programs in this field. Materials and Methods: A cross-sectional study was administrated. Ninety-eight participants agreed to complete an anonymous questionnaire. It was divided into two sections: the first section was about general information such as interviewer's gender and date of birth; the second section included questions about bisphosphonates (BPs), others medication associated to osteonecrosis of the jaw (ONJ), risk factors, and prevention of osteonecrosis...
October 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/29251459/phosphate-buffer-stabilized-0-1-chlorine-dioxide-oral-rinse-for-managing-medication-related-osteonecrosis-of-the-jaw
#5
REVIEW
Srinivas Rao Myneni Venkatasatya, Howard H Wang, Swetha Alluri, Sebastian G Ciancio
PURPOSE: This is a review of the literature on nonsurgical treatment of non-healing medication related osteonecrosis of the jaw (MRONJ) utilizing a phosphate buffer-stabilized 0.1% chlorine dioxide mouthrinse. METHODS: A literature search in PubMed revealed only six case reports. MRONJ lesion site description, patient's medication history, the healing time, and the MRONJ treatment protocol followed by those authors were recorded. Additional literature review of the scientific mechanism, risks and benefits, safety and efficacy of the phosphate buffer-stabilized 0...
December 2017: American Journal of Dentistry
https://www.readbyqxmd.com/read/29242516/mronj-risk-of-adjuvant-bisphosphonates-in-early-stage-breast-cancer
#6
V Patel, J Mansi, S Ghosh, J Kwok, M Burke, D Reilly, N Nizarali, C Sproat, K Chia
Medication-related osteonecrosis of the jaw (MRONJ) has most commonly been associated with bisphosphonates. The routine uses of these drugs are now well established predominantly in metastatic cancer with bone involvement, multiple myeloma, hypercalcaemia, osteoporosis and Paget's disease. Recently, however, the use of bisphosphonates in early breast cancer has shown a reduction in breast cancer recurrence and breast cancer deaths. This new indication for their use approximates to a further 20,000 women per year in the UK being prescribed bisphosphonates...
December 15, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29233703/the-risk-of-osteonecrosis-on-alveolar-healing-after-tooth-extraction-and-systemic-administration-of-antiresorptive-drugs-in-rodents-a-systematic-review
#7
REVIEW
Victor Lousan do Nascimento Poubel, Carolina Amália Barcellos Silva, Luis André Mendonça Mezzomo, Graziela De Luca Canto, Elena Riet Correa Rivero
PURPOSE: There is much concern about the increasing number of patients with medication-related osteonecrosis of the jaw (MRONJ), and many studies have been published in an attempt to understand the pathophysiology of this condition. This study aimed to systematically review the literature on MRONJ arising in rodents under antiresorptive drug therapy after tooth extraction. METHODS: A search of electronic databases, including LILACS, PROQUEST, PubMed, SCOPUS, and the Web of Science...
November 20, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29224060/differences-between-osteoradionecrosis-and-medication-related-osteonecrosis-of-the-jaw
#8
Masaya Akashi, Satoshi Wanifuchi, Eiji Iwata, Daisuke Takeda, Junya Kusumoto, Shungo Furudoi, Takahide Komori
PURPOSE: The appearance of osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) is similar, but clinically important differences between ORN and MRONJ exist. The aim of this study was to compare the clinical data between ORN and MRONJ and to reveal the critical differences between these diseases. METHODS: We retrospectively reviewed the epidemiological data, clinical findings, and treatment in 27 ORN and 61 MRONJ patients. Radiographic signs before the initiation of treatment were also assessed...
December 9, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29221983/medication-related-osteonecrosis-of-the-jaws-associated-with-targeted-therapy-as-monotherapy-and-in-combination-with-antiresorptives-a-report-of-7-cases-from-the-copenhagen-cohort
#9
Hoda Abel Mahedi Mohamed, Charlotte Emilie Nor Nielsen, Morten Schiodt
OBJECTIVE: The aim of this study was to report cases of medication-related osteonecrosis of the jaws (MRONJ) associated with targeted therapy (TT) with or without concomitant antiresorptive treatment, among the Copenhagen ONJ cohort, which includes all consecutive cases of MRONJ seen in Copenhagen. STUDY DESIGN: We retrospectively studied the treatment of 204 consecutive patients with MRONJ, seen between January 2010 and May 2016, to identify those associated with TT...
November 6, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29215447/cross-sectional-study-of-four-serological-bone-turnover-markers-for-the-risk-assessment-of-medication-related-osteonecrosis-of-the-jaw
#10
Andre Peisker, Gregor F Raschke, Mina D Fahmy, Arndt Guentsch, Korosh Roshanghias, Kai C König, Stefan Schultze-Mosgau
BACKGROUND: Despite the benefits related to the use of bisphosphonates and denosumab, medication-related osteonecrosis of the jaw (MRONJ) is a serious complication. The purpose of this study was to investigate the utility of 4 biochemical markers including serum c-terminal telopeptide cross-link of type I collagen (s-CTX), serum osteocalcin (s-OC), serum parathormon (s-PTH), and serum bone-specific alkaline phosphatase (s-BAP) as useful clinical tools to help assess the risk for MRONJ prior to invasive oral surgery...
December 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29192692/detecting-the-earliest-radiological-signs-of-bisphosphonate-related-osteonecrosis
#11
H Devlin, J Greenwall-Cohen, J Benton, T L Goodwin, A Littlewood, K Horner
Introduction Oral bisphosphonates are the most commonly prescribed anti-resorptive drugs used in the treatment of osteoporosis, but osteonecrosis of the jaw is a serious complication. The early diagnosis of this destructive side effect is crucial in preventing excessive bone loss, pain and infection.Objective To aid dental practitioners in the early identification of bisphosphonate-related osteonecrosis of the jaw.Method A scoping review was carried out.Data sources We searched MEDLINE via OVID, EMBASE via OVID, Dentistry and Oral Sciences Source (DOSS), Proquest Dissertation and Theses Search, to identify references that described clinical and radiological findings in medication-related osteonecrosis of the jaw (MRONJ)...
November 17, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29175416/can-autofluorescence-guide-surgeons-in-the-treatment-of-medication-related-osteonecrosis-of-the-jaw-a-prospective-feasibility-study
#12
Amerigo Giudice, Francesco Bennardo, Selene Barone, Alessandro Antonelli, Michele Mario Figliuzzi, Leonzio Fortunato
PURPOSE: The main limitation of surgical treatment of medication-related osteonecrosis of the jaw (MRONJ) is difficulty in defining resection margins. The aim of this study was to compare the efficacy of the surgeon's experience and autofluorescence-guided bone surgery to delimit resection margins for necrotic bone. MATERIALS AND METHODS: MRONJ requiring surgical treatment was classified according to American Association of Oral and Maxillofacial Surgeons staging...
November 23, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29168936/does-cbct-alter-the-diagnostic-thinking-efficacy-management-and-prognosis-of-patients-with-suspected-stage-0-medication-related-osteonecrosis-of-the-jaws
#13
Hiroaki Shimamoto, Tristan R Grogan, Tomomi Tsujimoto, Naoya Kakimoto, Shumei Murakami, David Elashoff, Tara L Aghaloo, Sotirios Tetradis
OBJECTIVES: To evaluate the impact of CBCT in the diagnostic thinking efficacy, management and prognosis of patients with suspected stage 0 medication-related osteonecrosis of the jaw (MRONJ). METHODS: For 15 patients with suspected stage 0 MRONJ, clinical photographs, a panoramic radiograph and selected CBCT sections were identified. 13 oral surgeons reviewed the material and answered 10 questions in two different sessions. First session included clinical photographs and panoramic radiographs, while second session also included CBCT images...
November 23, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29155533/conservative-prosthetic-rehabilitation-of-medication-related-osteonecrosis-of-the-jaw-mronj
#14
Alexandra Johanna Leven, Antony J Preston
Osteonecrosis of the jaw associated with bisphosphonates and other medications is a growing problem facing dentists. It can have a significant and debilitating impact upon patients. Various treatment options ranging from surgical intervention to management with antibiotics and analgesics have been proposed. This article presents one method of conservative treatment and prosthetic rehabilitation in a patient with ongoing BRONJ of the maxilla unsuitable for surgical management. Clinical relevance: Dentists need to be able to identify patients who are at risk of developing BRONJ and have an awareness of the appropriate management as well as potential oral rehabilitation options for these patients...
December 2016: Dental Update
https://www.readbyqxmd.com/read/29135723/oral-health-related-quality-of-life-after-surgical-treatment-of-osteonecrosis-of-the-jaws
#15
Giacomo Oteri, Francesco Saverio De Ponte, Michele Runci, Matteo Peditto, Antonia Marcianò, Marco Cicciù
The aim of this study is to analyze the clinical outcome and the change in oral-health-related quality of life (QoL) of osteoporotic patients affected by medication-related osteonecrosis of the jaws (MRONJ). Forty-one patients, consecutively treated for a 10-year period, were retrospectively analyzed. All the patients underwent a marginal osseous resective jaw surgery. A clinical 12 months postoperative evaluation has been performed and the complete mucosal healing, the absence of swelling and suppuration, and no signs of disease recurrence were defined like success parameters...
November 9, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29133970/laser-and-platelet-rich-plasma-to-treat-medication-related-osteonecrosis-of-the-jaws-mronj-a-case-report
#16
Carlo Fornaini, Luigi Cella, Aldo Oppici, Anna Parlatore, Fabio Clini, Matteo Fontana, Giuseppe Lagori, Elisabetta Merigo
Aims: The appropriate management of Medication-Related OsteoNecrosis of the Jaw (MRONJ) is still a challenge for dentists and oral surgeons and in these last years high-technology instruments have been proposed at the different steps of interventions, also combined with promoters of tissue repair.The aim of this report is to show the advantages of a combined approach (laser and PRP) for the treatment of MRONJ. Methods: It is described the case of a patient positive for MRONJ observed at the Odontostomatology and Maxillo-Facial Surgery Unit of the Hospital of Piacenza where surgical approach was performed by using different devices: Er:YAG laser (2940 nm) to remove and vaporize necrotic hard tissue until bleeding bone; Platelet-Rich Plasma (PRP) to stimulate hard and soft tissue healing; diode laser (808 nm) to biostimulate the surgical site...
September 30, 2017: Laser Therapy
https://www.readbyqxmd.com/read/29109954/role-of-periapical-diseases-in-medication-related-osteonecrosis-of-the-jaws
#17
Nian Jing Rao, Jing Yi Wang, Ru Qing Yu, Yiu Yan Leung, Li Wu Zheng
Objective: The present study aimed to investigate the role of periapical diseases in inducing medication-related osteonecrosis of the jaws (MRONJ) using an ovariectomized (OVX) mice model. Materials and Methods: Twenty C57BL/6N female mice were randomly assigned to two groups. All mice were subjected to bilateral ovariectomy and then treated with oncologic dose of zoledronic acid (ZA) or vehicle for twelve weeks. Eight weeks after commence of drug administration, a pulpal exposure (PE) operation was performed on the first right lower molar to induce periapical periodontitis; the contralateral non-PE tooth was used as control...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29104029/nasolabial-flap-improves-healing-in-medication-related-osteonecrosis-of%C3%A2-the-jaw
#18
Juliana Lemound, Thomas Muecke, Alexander-Nicolai Zeller, Jürgen Lichtenstein, André Eckardt, Nils-Claudius Gellrich
PURPOSE: Medication-related osteonecrosis of the jaw (MRONJ) is an adverse side effect of antiresorptive and antiangiogenic therapeutic agents that is difficult to treat owing to its high relapse rate. The aim of the present study was to determine whether patients with MRONJ treated using decortication and a nasolabial flap compared with those who underwent decortication with mucoperiosteal flaps have better outcomes regarding stable wound closure. MATERIALS AND METHODS: Two groups of patients with MRONJ and intraoral exposed bone were evaluated in a cohort clinical study retrospectively...
October 13, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29102331/vitamin-d-25-ohd-deficiency-may-increase-the-prevalence-of-medication-related-osteonecrosis-of-the-jaw
#19
Nils Heim, Felix Benjamin Warwas, Christian Timm Wilms, Rudolf H Reich, Markus Martini
INTRODUCTION: Osteonecrosis of the jaw (ONJ) is a severe complication of antiresorptive medication (AM) in the treatment of bone-affecting cancer-related conditions and osteoporosis. Aim of this study was to reveal whether patients treated with AM and show Medication Related OsteoNecrosis of the Jaw (MRONJ) are vitamin D deficient or not. MATERIALS AND METHODS: A 2 year retrospective study evaluated hospital records of 63 patients who received AM. Patients were divided into two groups...
September 23, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29101872/evaluation-of-the-bisphosphonate-effect-on-stem-cells-derived-from-jaw-bone-and-long-bone-rabbit-models-a-pilot-study
#20
Jun-Beom Park, Seung-Hyun Cho, InSoo Kim, Won Lee, Seung-Hwan Kang, Heesung Kim
BACKGROUND AND OBJECTIVE: Bisphosphonates have been widely used and the number of patients experiencing medication-related osteonecrosis of the jaw (MRONJ) has been increasing. This study was designed to evaluate the effect of zoledronate on stem cells derived from different tissues. DESIGN: Stem cells derived from four different tissues were compared using rabbit models (JPO: periosteum from the jaw bone (mandible), JBM: bone marrow from the jaw bone, LPO: periosteum from long bone (tibia), and LBM: bone marrow from long bone)...
October 31, 2017: Archives of Oral Biology
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