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https://www.readbyqxmd.com/read/28642516/oral-health-management-of-patients-at-risk-of-medication-related-osteonecrosis-of-the-jaw
#1
(no author information available yet)
The dentist should not be alarmist about the risk for the patient of developing medication-related osteonecrosis of the jaw (MRONJ).
June 23, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28622548/early-bony-changes-associated-with-bisphosphonate-related-osteonecrosis-of-the-jaws-in-rats-a-longitudinal-in-vivo-study
#2
Josy Lorena Peres Vilarinho, Nathália Ferrare, Andreia Maria Rocha Moreira, Helora Freitas Moura, Ana Carolina Acevedo, Sacha Braun Chaves, Nilce Santos Melo, André Ferreira Leite, Sérgio Bruzadelli Macedo, Melissa Paoletti de Souza, Ana Tereza Bittencourt Guimarães, Paulo Tadeu Figueiredo
OBJECTIVE: To evaluate early bony changes in an animal model of Medication-Related Osteonecrosis of the Jaw (MRONJ) at the side of the local trauma and at the contralateral side, comparing with a control group. Bony changes were evaluated by Microcomputed Tomography (MicroCT) at three times points: at baseline (T0), after drug administration (T1) and after dental extraction (T2). DESIGN: Two groups were compared: the experimental group in which zoledronic acid (ZA) was administered (17 rats) and the control group (13 rats)...
June 6, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28601298/the-effect-of-chronic-dental-inflammation-on-development-of-stage-0-medication-related-osteonecrosis-of-the-jaw
#3
Goknur Topaloglu, Osman Taha Koseoglu, Cigdem Karaca, Kemal Kosemehmetoglu
OBJECTIVE: The pathogenesis of medication-related osteonecrosis of jaw (MRONJ) is poorly understood. The aim of this prospective study was to determine the effect of chronic dental inflammation on the development of Stage 0 MRONJ based on histopathological findings. METHODS: The study involved patients with a history of bisphosphonate use and an indication for tooth extraction. Before surgery, C-terminal telopeptide test (CTX) values were collected from all patients...
May 12, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28587628/osteoclast-profile-of-medication-related-osteonecrosis-of-the-jaw-secondary-to-bisphosphonate-therapy-a-comparison-with-osteoradionecrosis-and-osteomyelitis
#4
Christian Gross, Manuel Weber, Kay Creutzburg, Patrick Möbius, Raimund Preidl, Kerstin Amann, Falk Wehrhan
BACKGROUND: The medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy [MRONJ (BP)] is characterized by non-healing exposed bone in the maxillofacial region. The pathogenesis of MRONJ (BP) is not fully understood. Giant, hypernucleated, inactive osteoclasts were found in MRONJ (BP) tissues, which indicated that accelerated cell-cell fusion might play a role. Dendritic cell-specific transmembrane protein (DC-STAMP) is associated with the cell-cell fusion of osteoclasts and precursor cells...
June 6, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28585700/evaluation-of-the-treatment-strategies-for-medication-related-osteonecrosis-of-the-jaws-mronj-and-the-factors-affecting-treatment-outcome-a-multicenter-retrospective-study-with-propensity-score-matching-analysis
#5
Saki Hayashida, Sakiko Soutome, Souichi Yanamoto, Shigeyuki Fujita, Takumi Hasegawa, Takahide Komori, Yuka Kojima, Hironori Miyamoto, Yasuyuki Shibuya, Nobuhiro Ueda, Tadaaki Kirita, Hirokazu Nakahara, Mitsuyo Shinohara, Masahiro Umeda
Medication-related osteonecrosis of the jaw (MRONJ) is an adverse event which may inhibit the treatment of primary disease and remarkably influence the patient's quality of life. The treatment methods for MRONJ, nonsurgical and surgical, are controversial, with no agreement as to which method provides the best outcome and should therefore be recommended. This multicenter retrospective study aimed to investigate the treatment methods and outcome in a large number of patients with MRONJ in Japan, utilizing propensity score matching analysis...
June 6, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28529150/preventive-effect-of-phosphodiesterase-inhibitor-pentoxifylline-against-medication-related-osteonecrosis-of-the-jaw-an-animal-study
#6
Gül Merve Yalcin-Ulker, Alev Cumbul, Gonca Duygu-Capar, Ünal Uslu, Kemal Sencift
PURPOSE: The aim of this experimental study was to investigate the prophylactic effect of pentoxifylline (PTX) on medication-related osteonecrosis of the jaw (MRONJ). MATERIALS AND METHODS: Female Sprague-Dawley rats (n = 33) received zoledronic acid (ZA) for 8 weeks to create an osteonecrosis model. The left mandibular second molars were extracted and the recovery period lasted 8 weeks before sacrifice. PTX was intraperitoneally administered to prevent MRONJ...
April 26, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28527518/effectiveness-of-treatments-for-medication-related-osteonecrosis-of%C3%A2-the-jaw-a-systematic-review-and-meta-analysis
#7
REVIEW
Mohamed El-Rabbany, Adam Sgro, David K Lam, Prakeshkumar S Shah, Amir Azarpazhooh
BACKGROUND: The effectiveness of management strategies used for the treatment of medication-related osteonecrosis of the jaw (MRONJ) remains poorly understood. The authors evaluated systematically the effectiveness of the various treatment modalities used for MRONJ. TYPES OF STUDIES REVIEWED: The authors conducted a comprehensive search of MEDLINE, Embase, the Cochrane Library, and Scopus to identify randomized controlled trials, nonrandomized controlled trials, and prospective cohort studies to evaluate comparatively the effectiveness of management strategies for the treatment of MRONJ...
May 18, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28497661/medication-related-osteonecrosis-of-the-jaw-risk-factors-in-patients-under-biphosphonate-versus-patients-under-antiresorptive-antiangiogenic-drugs
#8
Giulia Ghidini, Maddalena Manfredi, Ilaria Giovannacci, Giovanni Mergoni, Amin Sarraj, Maura Mureddu, Giovanna Giunta, Mauro Bonanini, Marco Meleti, Paolo Vescovi
BACKGROUND: Biphosphonate-Related Osteonecrosis of the Jaw (BRONJ) is a potential side effect associated with the administration of bisphosphonates; the aim of this work is to highlight the possible epidemiological differences between two groups of patients affected by MRONJ treated at the Center of Oral Medicine, Pathology and Laser Surgery of the Academic Hospital at the University of Parma, Italy, between January 2004 and June 2016. METHODS: Medical charts of 303 patients (214 Females and 89 Males, mean age 67y) treated at the Center of Oral Medicine, Pathology and Laser Surgery of the Academic Hospital at the University of Parma, between January 2004 and June 2016, were retrospectively analyzed...
May 10, 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/28451732/a-multicenter-retrospective-study-of-the-risk-factors-associated-with-medication-related-osteonecrosis-of-the-jaw-after-tooth-extraction-in-patients-receiving-oral-bisphosphonate-therapy-can-primary-wound-closure-and-a-drug-holiday-really-prevent-mronj
#9
T Hasegawa, A Kawakita, N Ueda, R Funahara, A Tachibana, M Kobayashi, E Kondou, D Takeda, Y Kojima, S Sato, S Yanamoto, H Komatsubara, M Umeda, T Kirita, H Kurita, Y Shibuya, T Komori
Root amputation, extraction of a single tooth, bone loss or severe tooth mobility, and an unclosed wound were significantly associated with increased risk of developing medication-related osteonecrosis of the jaw (MRONJ). We recommend a minimally traumatic extraction technique, removal of any bone edges, and mucosal wound closure as standard procedures in patients receiving bisphosphonates. INTRODUCTION: Osteonecrosis of the jaws can occur following tooth extraction in patients receiving bisphosphonate drugs...
April 27, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28396234/intraoral-vacuum-assisted-closure-therapy-a-pilot-study-in-medication-related-osteonecrosis-of-the-jaw
#10
Johannes Laimer, Otto Steinmassl, Martin Hechenberger, Michael Rasse, Rajmond Pikula, Emanuel Bruckmoser
PURPOSE: For approximately 2 decades, vacuum-assisted closure (VAC) therapy has been widely used for the management of complex wounds and soft tissue defects on the external surface of the body. As yet, this technique has not been studied for intraoral wound management. Therefore, this study evaluated the feasibility, safety, and effectiveness of intraoral VAC therapy in patients with medication-related osteonecrosis of the jaw (MRONJ). PATIENTS AND METHODS: After successful construction of an intraoral device providing sufficient airtight sealing, individually manufactured appliances were used in a prospective clinical trial of 3 patients using the VAC therapy system...
March 18, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28352284/radiographic-findings-in-patients-with-medication-related-osteonecrosis-of-the-jaw
#11
Camila Lopes Cardoso, Carolina Arrabal Barros, Cláudia Curra, Luciana Maria Paes da Silva Ramos Fernandes, Solange de Oliveira Braga Franzolin, Joel Santiago Ferreira Júnior, Carlos César De Antoni, Marcos Martins Curi
A retrospective study was conducted of the records and panoramic radiographs of 35 patients treated with bisphosphonates (BP) and diagnosed with MRONJ. Panoramic radiography was used for evaluation, by two examiners, the following findings were subject of search: osteolysis (OT), cortical bone erosion (EC), bone sclerosis focal (FS) and diffuse (DS), bone sequestration (BS), thickening of lamina dura (TD), prominence of the inferior alveolar nerve canal (IAN), persisting alveolar sockets (SK), and the presence of a pathological fracture (PF)...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28289268/meaning-and-limitation-of-cortical-bone-width-measurement-with-dentascan-in-medication-related-osteonecrosis-of-the-jaws
#12
Eiji Iwata, Masaya Akashi, Megumi Kishimoto, Junya Kusumoto, Takumi Hasegawa, Shungo Furudoi, Takahide Komori
Mandibular cortical bone measurement with x-ray imaging is known to be a potentially useful tool in the detection of dimensional changes caused by bisphosphonate. The primary purpose of this study was to assess the meaning and limitation of cortical bone measurement with computed tomography (CT) in patients with medication-related osteonecrosis of the jaw (MRONJ). The investigators obtained DentaScan images of the mandible from 15 patients with MRONJ, 15 patients with a history of antiresorptive agent administration without symptoms of MRONJ (non-MRONJ), and 15 control subjects...
February 15, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/28281587/mronj-risk-reduction-pathway-360-degree-survey
#13
A Muthukrishnan, S Al-Ismail, G Bertelli, P Browne
Introduction Bisphosphonates and denosumab reduce the risk of skeletal events in some malignancies (for example, breast, myeloma). These drugs carry a significant risk of a difficult-to-manage side effect of medication related osteonecrosis of the jaw (MRONJ). Preventive dental screening and treatment reduces the incidence of MRONJ. A managed clinical network (MCN) has been used to provide a MRONJ risk reduction pathway. A 360 degree survey was undertaken to assess the effectiveness of the pathway.Aim The aim of the 360 degree survey was to evaluate if this preventive pathway fulfilled its aims based on patient and stakeholder responses...
March 10, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28241916/the-prevention-of-medication-related-osteonecrosis-of-the-jaw
#14
Philipp Poxleitner, Monika Engelhardt, Rainer Schmelzeisen, Pit Voss
BACKGROUND: Medication-related osteonecrosis of the jaw (MRONJ) is a preventable complication of antiresorptive treatment. It arises in 1-20% of patients with bone metastases of solid tumors and hematologic malignancies and in 0.1-2% of patients being treated for osteoporosis with bisphosphonates. Depending on the underlying disease and medication dosage, the risk of MRONJ can be elevated even in the first year of antiresorptive treatment. The treatment of MRONJ is difficult and often involves surgery of the jaw...
February 3, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28220264/treatment-of-stage-ii-medication-related-osteonecrosis-of-the-jaw-with-necrosectomy-and-autologous-bone-marrow-mesenchymal-stem-cells
#15
Pit Jacob Voss, Akihiko Matsumoto, Esteban Alvarado, Rainer Schmelzeisen, Fabian Duttenhöfer, Philipp Poxleitner
Treatment strategies for medication-related osteonecrosis of the jaw (MRONJ) remain controversial. Although the AAOMS suggests a conservative approach, a surgical management with necrosectomy is often required when conservative management has failed. Moreover, recent studies have shown promising results using an early stage surgical treatment. Over the past decade, cell-based bone regeneration utilizing bone marrow mesenchymal stem cells (MSCs) received increased attention. MSCs are known to promote wound healing and induce new bone formation in compromised tissue...
February 20, 2017: Odontology
https://www.readbyqxmd.com/read/28174631/medication-related-osteonecrosis-of-the-jaws-caused-lethal-sepsis-in-an-edentulous-patient-with-multiple-systemic-factors
#16
Keisuke Yamashiro, Aki Sato, Fumihiko Okazaki, Makoto Nakano, Koichi Sawaki, Yasuhisa Hirata, Eiki Yamachika, Seiji Iida, Shogo Takashiba
Medication-related osteonecrosis of the jaw (MRONJ) is developed even in the patients who are edentulous and treated with short-term bisphosphonate therapy and oral administration. It sometimes causes lethal sepsis in patients who have multiple health problems such as diabetes, cirrhosis, steroid use for interstitial pneumonia, sepsis, and spinal disk herniation.
February 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28162845/role-of-microbiological-culture-and-polymerase-chain-reaction-pcr-of-actinomyces-in-medication-related-osteonecrosis-of-the-jaw-mronj
#17
Sappasith Panya, Riham Fliefel, Florian Probst, Matthias Tröltzsch, Michael Ehrenfeld, Sören Schubert, Sven Otto
We hypothesized that local infection plays a critical role in the pathogenesis of medication-related osteonecrosis of the jaw (MRONJ). Recent developments in molecular methods have revolutionized new approaches for the rapid detection of microorganisms including those difficult to culture. The aim of our study is to identify the bacterial profiles in MRONJ by microbiological culture and polymerase chain reactions (PCR). A retrospective analysis was performed on MRONJ patients from 2008 to 2014. The bacterial profile from MRONJ bone samples was determined using microbiological culture and PCR...
March 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28159588/bacterial-diversity-in-medication-related-osteonecrosis-of-the-jaw
#18
Fredrik Hallmer, Tore Bjørnland, Gunilla Andersson, Jonas P Becktor, Anne K Kristoffersen, Morten Enersen
OBJECTIVE: The aim was to study the association between microflora and medication-related osteonecrosis of the jaw (MRONJ) by using culture-independent molecular techniques to detect bacteria in necrotic bone lesions. STUDY DESIGN: Included were 18 consecutive patients with MRONJ, 10 with osteoporosis and 8 cancer patients. Bone biopsies were retrieved from the center of the necrotic bone and from visually healthy bone, and 16 S rRNA gene fragments from bacterial DNA were amplified with polymerase chain reaction...
December 7, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28149479/prophylaxis-and-antibiotic-therapy-in-management-protocols-of-patients-treated-with-oral-and-intravenous-bisphosphonates
#19
REVIEW
Elena-Beatriz Bermúdez-Bejarano, María-Ángeles Serrera-Figallo, Aida Gutiérrez-Corrales, Manuel-María Romero-Ruiz, Raquel Castillo-de-Oyagüe, José-Luis Gutiérrez-Pérez, Daniel Torres-Lagares
INTRODUCTION: Osteonecrosis of the jaw (MRONJ) linked to bisphosphonate treatment has specific characteristics that render its therapeutic management challenging for clinicians. Poor response to standard treatment makes it essential to take special precautions when treating this type of disease; therefore, antibiotic prophylaxis and/or antibiotic therapy have been proposed as effective and helpful tools in these situations. OBJECTIVES: This article seeks to assess published evidence in order to evaluate the different protocols used for antibiotic prophylaxis and/or antibiotic therapy in the general context of patients treated with bisphosphonates...
January 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28126996/awareness-of-medication-related-osteonecrosis-of-the-jaws-mronj-amongst-general-dental-practitioners
#20
N Tanna, C Steel, S Stagnell, E Bailey
Background Recent evidence suggests that medication-related osteonecrosis of the jaw (MRONJ) can be caused by a number of anti-resorptive and anti-angiongenic agents not limited to bisphosphonates. A working knowledge of these medications is important for dental practitioners.Methods A total of 129 general dental practitioners (GDPs) were surveyed regarding their awareness of MRONJ and its causes.Results More than 90% of the GDPs sampled were unaware of anti-resorptive and anti-angiogenic medications other than bisphosphonates that had the potential to cause MRONJ...
January 27, 2017: British Dental Journal
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