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https://www.readbyqxmd.com/read/28936298/the-role-of-leucocyte-rich-and-platelet-rich-fibrin-l-prf-in-the-treatment-of-the-medication-related-osteonecrosis-of-the-jaws-mronj
#1
REVIEW
Jorge A Cano-Durán, Juan-Francisco Peña-Cardelles, Daniel Ortega-Concepción, Víctor M Paredes-Rodríguez, Mariano García-Riart, Juan López-Quiles
BACKGROUND: For the treatment of the bisphosphonates and other drugs related osteonecrosis of the jaws, currently medication-related osteonecrosis of the jaws (MRONJ), have been established different conservative therapeutic approaches, avoiding surgery except in cases of extreme need. Given the controversy and lack of current consensus regarding MRONJ therapy in patients, new techniques have been developed among which the use of fibrin membranes rich in platelets and leukocytes (L-PRF)...
August 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28916324/in%C3%A2-vitro-investigation-of-the-antimicrobial-effect-of-three-bisphosphonates-against-different-bacterial-strains
#2
Michael A Ermer, Simon C Kottmann, Jörg-Elard Otten, Annette Wittmer, Philipp Poxleitner, Klaus Pelz
PURPOSE: Since the first descriptions of medication-related osteonecrosis of the jaw (MRONJ) in 2003, the pathogenesis has remained unanswered. Recent histomorphometric studies have found several microorganisms, including Actinomyces, Bacillus, Fusobacterium, Staphylococcus, Streptococcus, Selenomonas, Treponema, and Candida albicans in necrotic bone. Polymerase chain reaction studies have recently confirmed the occurrence of 48 genera. Only a few studies have examined the antimicrobial effect of bisphosphonates (BPs)...
August 31, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28877577/a-case-of-pentastomiasis-at-the-left-maxilla-bone-in-a-patient-with-thyroid-cancer
#3
Eunae Sandra Cho, Seung Wook Jung, Hwi-Dong Jung, In Yong Lee, Tai-Soon Yong, Su Jin Jeong, Hyun Sil Kim
Pentastomiasis, a zoonotic parasite infection, is typically found in the respiratory tract and viscera of the host, including humans. Here, we report for the first time an extremely rare case of intraosseous pentastomiasis in the human maxilla suffering from medication related osteonecrosis of the jaw (MRONJ). A 55-year-old male had continuously visited the hospital for MRONJ which had primarily developed after bisphosphonate and anti-neoplastic administration for previous bone metastasis of medullary thyroid cancer...
August 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28871814/osseous-changes-in-patients-with-medicationrelatedosteonecrosis-of-the-jaws
#4
Zeynep Burcin Gönen, Canay Yillmaz Asan, Gökmen Zararsiz, Erdem Kiliç, Alper Alkan
OBJECTIVES: Medication-Related Osteonecrosis of the Jaw (MRONJ) is a severe side effect of antiresorptive agents. The aim of this study was to investigate the osseous changes in patients with MRONJ. METHODS: Cone Beam Computed Tomography (CBCT) images of 25 patients with MRONJ and controls were retrospectively evaluated. Buccal, lingual, apical cortical bone thicknesses; buccal, lingual, apical intracortical and cancellous bone density; diameter of mental foramen and incisive canal, and width of mental foramen were measured...
September 5, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28857991/spontaneous-healing-of-clodronate-related-osteonecrosis-of-the-jaw
#5
Enrico Nastro Siniscalchi, Alessandro Allegra, Francesco Saverio De Ponte, Giacomo Oteri, Gabriele Cervino, Floriana Lauritano, Caterina Musolino, Marco Cicciù
Cases of medication-related osteonecrosis of the jaw (MRONJ) have been more commonly associated with aminobiphosphonate therapy than with alkylbiphosphonate treatment. Here, we report a case of MRONJ in a subject who received an alkylbiphosphonate, clodronate, for the treatment of osteoporosis, and discuss the pathogenic mechanisms of alkylbiphosphonates and the possible reasons for the spontaneous and rapid remission of MRONJ occurring in our patient.
August 28, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28854059/surgical-treatment-of-stage-2-medication-related-osteonecrosis-of-the-jaw-compared-to-osteomyelitis
#6
Sang-Hoon Kang, Yu-Jin Won, Moon-Key Kim
OBJECTIVE: To compare the characteristics and outcomes of patients who underwent surgical treatment for stage 2 medication-related osteonecrosis of the jaw (MRONJ) versus osteomyelitis. METHODS: This retrospective study compared the following variables in 73 patients with stage 2 MRONJ versus 89 patients with osteomyelitis: impaired wound healing after surgery, sex, age, the presence of actinomycosis, location of the jaw lesion, and involvement of the inferior alveolar nerve (IAN)...
August 30, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/28851496/diagnostic-dilemma-between-medication-related-osteonecrosis-and-oral-squamous-cell-carcinoma-in-a-mandibular-lytic-lesion
#7
S Tocaciu, O Breik, B Lim, C Angel, N Rutherford
Osteolytic lesions of the mandible are common, and there are two important differential diagnoses that must be considered: medication-related osteonecrosis of the jaws (MRONJ) and squamous cell carcinoma (SCC). In patients with a history of taking antiresorptive medication as well as risk factors for neoplasia it can be difficult to differentiate between the two. We describe two cases in both of which a mandibular osteolytic lesion was inadequately identified as either MRONJ or SCC because of confusing clinical and histopathological features...
August 26, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28838836/relevant-factors-for-treatment-outcome-and-time-to-healing-in-medication-related-osteonecrosis-of-the-jaws-a-retrospective-cohort-study
#8
Ana Silva Martins, João André Correia, Francisco Salvado, Cecília Caldas, Nuno Santos, António Capelo, Paulo Palmela
BACKGROUND: Risk factors for medication-related osteonecrosis of the jaw (MRONJ) are well known, although few studies evaluate the factors that influence treatment outcomes in MRONJ and whether discontinuing antiresorptive medication influences healing. PURPOSE: (1) Describe the characteristics of a population of patients with MRONJ. (2) Identify the factors associated with favourable outcomes. (3) Identify a temporal correlation between discontinuation of antiresorptives and healing time...
July 28, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28815779/short-term-teriparatide-and-recombinant-human-bone-morphogenetic-protein-2-for-regenerative-approach-to-medication-related-osteonecrosis-of-the-jaw-a-preliminary-study
#9
Junho Jung, Hee-Young Yoo, Gyu-Tae Kim, Jung-Woo Lee, Yeon-Ah Lee, Deog-Yoon Kim, Yong-Dae Kwon
Our objective was to examine whether adjunct teriparatide administration and local application of recombinant human bone morphogenetic protein-2 (rhBMP-2) is beneficial for the regeneration of jaw bone in patients with medication-related osteonecrosis of the jaw (MRONJ). This study enrolled 17 patients diagnosed with MRONJ. All patients received sequestrectomy under general or local anesthesia with suspension of bisphosphonate. The bone regeneration ratio was compared on cone beam computed tomography (CBCT) scans, acquired immediately post-operation and after 6 months...
August 16, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28803745/further-development-of-the-mronj-minipig-large-animal-model
#10
Sven Otto, Christoph Pautke, Olga Martin Jurado, Dirk Nehrbass, Martin J Stoddart, Michael Ehrenfeld, Stephan Zeiter
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious and potentially severe side effect of antiresorptive therapy with bisphosphonates or denosumab. Recently, a large animal minipig MRONJ model was introduced which led to early necrotic lesions in the majority of extraction sites after bisphosphonate administration. The aim of this project was to modify the preoperative cumulative bisphosphonate dose (zoledronate) and hereby firstly to demonstrate the reliability and reproducibility of the established model...
September 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28772087/selective-percutaneous-controlled-radiofrequency-thermocoagulation-of-the-gasserian-ganglion-to-control-facial-pain-due-to-medication-related-osteonecrosis-of-the-jaw
#11
Ayano Taniguchi, Keita Fukazawa, Toyoshi Hosokawa
BACKGROUND: Medication-related osteonecrosis of the jaw (MRONJ) is an important complication in patients treated with antiresorptive agents such as bisphosphonates and the receptor activator of nuclear factor κB ligand inhibitor (denosumab). Treatment of MRONJ is extremely difficult, which makes it a distressing long-term complication. OBJECTIVES: We report a case of intractable facial pain due to MRONJ that was successfully controlled with selective percutaneous controlled radiofrequency thermocoagulation of the Gasserian ganglion...
August 3, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28760314/medication-related-osteonecrosis-of-the-jaw-in-oncological-patients-with-skeletal-metastases-conservative-treatment-is-effective-up-to-stage-2
#12
R G Coropciuc, K Grisar, T Aerden, M Schol, J Schoenaers, C Politis
There is currently no widespread strategy for treating medication-related osteonecrosis of the jaw (MRONJ), so our aim was to evaluate retrospectively the outcome of a minimally invasive treatment protocol for patients with both MRONJ and cancer. We designed a retrospective cohort study of patients with cancer who had been diagnosed with MRONJ after treatment with denosumab or bisphosphonates given intravenously. Primary outcome measures were improvement in the clinical stage of MRONJ and the time course to its resolution...
July 28, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28699091/the-effects-of-ozone-application-on-genotoxic-damage-and-wound-healing-in-bisphosphonate-applied-human-gingival-fibroblast-cells
#13
Sıdıka Sinem Akdeniz, E Beyler, Y Korkmaz, E Yurtcu, U Ates, K Araz, F I Sahin, O Y Torun
OBJECTIVES: Medication-related osteonecrosis of the jaws (MRONJ) is an extremely therapy-resistant disease involving the jaws especially following bisphosphonate treatment. Bisphosphonates accumulate in bone in concentrations sufficient to be directly toxic to the oral epithelium. Current therapeutic options are inadequate for the prevention and treatment of MRONJ. The aim of this study was to investigate effects of ozone gas plasma therapy on wound healing in bisphosphonate-applied human fibroblasts...
July 11, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28697987/update-mronj-and-perspectives-of-its-treatment
#14
P J Voss, P Poxleitner, R Schmelzeisen, A Stricker, W Semper-Hogg
Antiresorptive agents are widely used in catabolic bone diseases. Not only bisphosphonates but also new drugs like Denosumab may induce osteonecrosis of the jaw as a side effect. The present review describes the current effect mechanisms of commonly used antiresorptives, pathogenetic theories for the development of antiresorptive-related osteonecrosis of the jaw (ARONJ), and potential risk factors. Furthermore, diagnostic modalities and treatment options as well as new and innovative strategies are discussed...
September 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28687467/what-is-the-effect-of-anti-resorptive-drugs-ards-on-the-development-of-medication-related-osteonecrosis-of-the-jaw-mronj-in-osteoporosis-patients-a-systematic-review
#15
Suad Aljohani, Riham Fliefel, Jacob Ihbe, Jan Kühnisch, Michael Ehrenfeld, Sven Otto
PURPOSE: To conduct a systematic review of the literature to detect the effect of anti-resorptive drugs (ARDs) and their administration characteristics in the development of medication-related osteonecrosis of the jaw (MRONJ) in osteoporosis patients. METHODS: Systematic search in PubMed, Web of Sciences and Cochrane Library was performed for relevant studies to July 2016. Population variables (age, gender, comorbidities, medications, preceding events, number of patients with MRONJ), ARDs and clinical variables were abstracted independently from these articles...
September 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28684826/aggressive-denosumab-related-jaw-necrosis-a-case-series
#16
M Badr, E Kyriakidou, A Atkins, S Harrison
Medication related osteonecrosis of the jaw is becoming a repeatedly seen complication in cancer patients. Stage 0 of the disease is more likely to be seen by the patients' general dental practitioners. We are presenting four cases of MRONJ related to denosumab treatment showing increasingly aggressive pictures of the disease. Nevertheless, we also present a good response to a drug holiday arranged by the patients' treating oncologists.
July 7, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28684074/the-impact-of-surgical-intervention-and-antibiotics-on-mronj-stage-ii-and-iii-retrospective-study
#17
Matthias Zirk, Matthias Kreppel, Johannes Buller, Julij Pristup, Franziska Peters, Timo Dreiseidler, Max Zinser, Joachim E Zöller
OBJECTIVES: Metastatic bone disease and osteoporosis are the main indications for bisphosphonates and anti-resorptive agent therapy. Inhibition of bone turnover and angiogenesis are mainly responsible for the development of Medication Related Osteonecrosis of Jaws (MRONJ) as therapeutic side-effect. Yet, the role of infection for the development and recurrence of MRONJ is not fully elucidated. The aim of this retrospective study is to explore if a difference in antibiotic regimes has an impact on the surgical intervention needed to achieve a painless stable stage of the disease...
June 4, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28675810/use-of-leukocyte-and-platelet-rich-fibrin-in-the-treatment-of-medication-related-osteonecrosis-of-the-jaws
#18
Gustavo Maluf, Rogério Jardim Caldas, Paulo Sérgio Silva Santos
Lesions associated with medication-related osteonecrosis of the jaws (MRONJ) are refractory to different treatment approaches. Hence, auxiliary approaches capable of improving patient outcomes should be explored. Leukocyte- and platelet-rich fibrin (LPRF) is a second-generation platelet concentrate (natural autologous fibrin matrix). It shows anti-infectious activity through immune regulation and accelerates the angiogenesis and multiplication of fibroblasts and osteoblasts; in consequence, it stimulates soft tissue healing and prevents exposure of the alveolar bone in the oral cavity...
June 12, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28656643/risk-factors-for-medication-related-osteonecrosis-of-the-jaws-a-systematic-review
#19
REVIEW
Kelly McGowan, Troy McGowan, Saso Ivanovski
OBJECTIVE: The purpose of this study was to identify the patient populations at risk of medication related osteonecrosis of the jaw (MRONJ) and determine which medical and dental comorbidities are significant risk factors for this disease. METHODS: An electronic search of Embase, MEDLINE, Cochrane Central Register of Controlled Trials, WHO International Clinical Trials Registry Platform and ProQuest Dissertations and Theses Global was conducted to identify all human studies that reported risk factors for MRONJ...
June 28, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28642516/oral-health-management-of-patients-at-risk-of-medication-related-osteonecrosis-of-the-jaw
#20
(no author information available yet)
The dentist should not be alarmist about the risk for the patient of developing medication-related osteonecrosis of the jaw (MRONJ).
June 23, 2017: British Dental Journal
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