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https://www.readbyqxmd.com/read/29135723/oral-health-related-quality-of-life-after-surgical-treatment-of-osteonecrosis-of-the-jaws
#1
Giacomo Oteri, Francesco Saverio De Ponte, Michele Runci, Matteo Peditto, Antonia Marcianò, Marco Cicciù
The aim of this study is to analyze the clinical outcome and the change in oral-health-related quality of life (QoL) of osteoporotic patients affected by medication-related osteonecrosis of the jaws (MRONJ). Forty-one patients, consecutively treated for a 10-year period, were retrospectively analyzed. All the patients underwent a marginal osseous resective jaw surgery. A clinical 12 months postoperative evaluation has been performed and the complete mucosal healing, the absence of swelling and suppuration, and no signs of disease recurrence were defined like success parameters...
November 9, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29133970/laser-and-platelet-rich-plasma-to-treat-medication-related-osteonecrosis-of-the-jaws-mronj-a-case-report
#2
Carlo Fornaini, Luigi Cella, Aldo Oppici, Anna Parlatore, Fabio Clini, Matteo Fontana, Giuseppe Lagori, Elisabetta Merigo
Aims: The appropriate management of Medication-Related OsteoNecrosis of the Jaw (MRONJ) is still a challenge for dentists and oral surgeons and in these last years high-technology instruments have been proposed at the different steps of interventions, also combined with promoters of tissue repair.The aim of this report is to show the advantages of a combined approach (laser and PRP) for the treatment of MRONJ. Methods: It is described the case of a patient positive for MRONJ observed at the Odontostomatology and Maxillo-Facial Surgery Unit of the Hospital of Piacenza where surgical approach was performed by using different devices: Er:YAG laser (2940 nm) to remove and vaporize necrotic hard tissue until bleeding bone; Platelet-Rich Plasma (PRP) to stimulate hard and soft tissue healing; diode laser (808 nm) to biostimulate the surgical site...
September 30, 2017: Laser Therapy
https://www.readbyqxmd.com/read/29109954/role-of-periapical-diseases-in-medication-related-osteonecrosis-of-the-jaws
#3
Nian Jing Rao, Jing Yi Wang, Ru Qing Yu, Yiu Yan Leung, Li Wu Zheng
Objective: The present study aimed to investigate the role of periapical diseases in inducing medication-related osteonecrosis of the jaws (MRONJ) using an ovariectomized (OVX) mice model. Materials and Methods: Twenty C57BL/6N female mice were randomly assigned to two groups. All mice were subjected to bilateral ovariectomy and then treated with oncologic dose of zoledronic acid (ZA) or vehicle for twelve weeks. Eight weeks after commence of drug administration, a pulpal exposure (PE) operation was performed on the first right lower molar to induce periapical periodontitis; the contralateral non-PE tooth was used as control...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29104029/nasolabial-flap-improves-healing-in-medication-related-osteonecrosis-of%C3%A2-the-jaw
#4
Juliana Lemound, Thomas Muecke, Alexander-Nicolai Zeller, Jürgen Lichtenstein, André Eckardt, Nils-Claudius Gellrich
PURPOSE: Medication-related osteonecrosis of the jaw (MRONJ) is an adverse side effect of antiresorptive and antiangiogenic therapeutic agents that is difficult to treat owing to its high relapse rate. The aim of the present study was to determine whether patients with MRONJ treated using decortication and a nasolabial flap compared with those who underwent decortication with mucoperiosteal flaps have better outcomes regarding stable wound closure. MATERIALS AND METHODS: Two groups of patients with MRONJ and intraoral exposed bone were evaluated in a cohort clinical study retrospectively...
October 13, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29102331/vitamin-d-25-ohd-deficiency-may-increase-the-prevalence-of-medication-related-osteonecrosis-of-the-jaw
#5
Nils Heim, Felix Benjamin Warwas, Christian Timm Wilms, Rudolf H Reich, Markus Martini
INTRODUCTION: Osteonecrosis of the jaw (ONJ) is a severe complication of antiresorptive medication (AM) in the treatment of bone-affecting cancer-related conditions and osteoporosis. Aim of this study was to reveal whether patients treated with AM and show Medication Related OsteoNecrosis of the Jaw (MRONJ) are vitamin D deficient or not. MATERIALS AND METHODS: A 2 year retrospective study evaluated hospital records of 63 patients who received AM. Patients were divided into two groups...
September 23, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29101872/evaluation-of-the-bisphosphonate-effect-on-stem-cells-derived-from-jaw-bone-and-long-bone-rabbit-models-a-pilot-study
#6
Jun-Beom Park, Seung-Hyun Cho, InSoo Kim, Won Lee, Seung-Hwan Kang, Heesung Kim
BACKGROUND AND OBJECTIVE: Bisphosphonates have been widely used and the number of patients experiencing medication-related osteonecrosis of the jaw (MRONJ) has been increasing. This study was designed to evaluate the effect of zoledronate on stem cells derived from different tissues. DESIGN: Stem cells derived from four different tissues were compared using rabbit models (JPO: periosteum from the jaw bone (mandible), JBM: bone marrow from the jaw bone, LPO: periosteum from long bone (tibia), and LBM: bone marrow from long bone)...
October 31, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29071028/successful-use-of-lower-level-laser-therapy-in-the-treatment-of-medication-related-osteonecrosis-of-the-jaw
#7
Gustavo Antonio Correa Momesso, Fábio Roberto de Souza Batista, Cecília Alves de Sousa, Valthierre Nunes de Lima, Tárik Ocon Braga Polo, Jaqueline Suemi Hassumi, Idelmo Rangel Garcia Júnior, Leonardo Perez Faverani
Case Presentation: This study aimed to report a case of medication related osteonecrosis of the jaw (MRONJ) of a 65-year-old female patient referred to the Oral and Maxillofacial Surgery team from Araçatuba Dental School, complaining about mobility of a previously dental implant placed on the posterior maxillary region. Clinical examination revealed an extensive necrosis area around the implant region. The patient reported bisphosphonate therapy with sodium alendronate for prevention of osteoporosis 5 years ago...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29056286/methotrexate-associated-osteonecrosis-of-the-jaw-a-report-of-two-cases
#8
Marianne Henien, Barbara Carey, Esther Hullah, Chris Sproat, Vinod Patel
There has been a rise in medication-related osteonecrosis of the jaw (MRONJ) predominantly related to antiresorptive and antiangiogenic medications. More evidence is revealing that MRONJ is not limited to these drug groups. With the introduction of newer and varied medications used in the treatment of cancer and autoimmune diseases, reports of possible related osteonecrosis of the jaw (ONJ) are also on the rise. We present 2 cases of ONJ in patients with long-standing arthritis treated with methotrexate in the absence of a lymphoproliferative disorder and antiresorptive or antiangiogenic medications...
September 21, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29053660/the-assessment-of-surgical-and-non-surgical-treatment-of-stage-ii-medication-related-osteonecrosis-of-the-jaw
#9
T Eguchi, I Kanai, A Basugi, Y Miyata, M Inoue, Y Hamada
BACKGROUND: Non-surgical treatment has generally been recommended for stage II medication-related osteonecrosis of the jaw (MRONJ) in preference to surgery. However, non-surgical treatment is not empirically effective. The aim of this study was to evaluate whether surgical or non-surgical treatment leads to better outcomes for stage II MRONJ. MATERIAL AND METHODS: In this retrospective study, surgery was performed in a total of 28 patients while 24 patients underwent non-surgical treatment...
November 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28983908/interventions-for-managing-medication-related-osteonecrosis-of-the-jaw
#10
REVIEW
Natalie H Beth-Tasdogan, Benjamin Mayer, Heba Hussein, Oliver Zolk
BACKGROUND: Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse reaction experienced by some individuals to certain medicines commonly used in the treatment of cancer and osteoporosis (e.g. bisphosphonates, denosumab and antiangiogenic agents) and involves the progressive destruction of bone in the mandible or maxilla. Depending on the drug, its dosage, and the duration of exposure, the occurrence of this adverse drug reaction may be rare (e.g. following the oral administration of bisphosphonate or denosumab treatments for osteoporosis, or antiangiogenic agent-targeted cancer treatment) or common (e...
October 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28981207/medication-related-osteonecrosis-of-the-posterior-maxilla-surgical-treatment-using-a-combined-transnasal-endoscopic-and-intraoral-approach-our-experience-with-seven-consecutive-patients
#11
Pasquale Procacci, Massimo Albanese, Lorenzo Trevisiol, Vittorio Favero, Dario Bertossi, Fabio Lonardi, Antonio D'Agostino, Erminia Manfrin, Pier Francesco Nocini
Upper jaw MRONJ if not correctly treated can lead to serious complication. Upper jaw MRONJ is frequently associated with maxillary sinusitis, the disease can spread to other paranasal sinuses. Combined approach is the most reliable procedure to treat odontogenic sinusitis; although MRONJ associated sinusitis is considered odontogenic there is no report in literature describing combined approach to treat MRONJ-induced sinusitis. Buccal fat pad represents the best reconstructive option to close the bony defect...
October 5, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28963584/incidence-of-medication-related-osteonecrosis-of-the-jaw-in-patients-treated-with-both-bone-resorption-inhibitors-and-vascular-endothelial-growth-factor-receptor-tyrosine-kinase-inhibitors
#12
T van Cann, T Loyson, A Verbiest, P M Clement, O Bechter, L Willems, I Spriet, R Coropciuc, C Politis, R O Vandeweyer, J Schoenaers, P R Debruyne, H Dumez, P Berteloot, P Neven, K Nackaerts, F J S H Woei-A-Jin, K Punie, H Wildiers, B Beuselinck
BACKGROUND: Several case reports and small case series have suggested a higher incidence of medication-related osteonecrosis of the jaw (MRONJ) in patients treated concomitantly with bone resorption inhibitors (BRIs) and vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs), as compared to patients treated with BRIs alone. We aimed to assess ONJ-incidence in patients exposed concomitantly to BRIs and VEGFR-TKIs. PATIENTS AND METHODS: We reviewed the records of all patients who received VEGFR-TKIs concomitantly with BRIs...
September 30, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28958140/platelet-rich-fibrin-in-the-management-of-medication-related-osteonecrosis-of-the-jaw-a-clinical-and-histopathological-evaluation
#13
F Inchingolo, S Cantore, G Dipalma, I Georgakopoulos, M Almasri, E Gheno, A Motta, M Marrelli, D Farronato, A Ballini, A Marzullo
Bisphosphonates are antiresorptive pharmacological agents used in the treatment of osteoporosis. Recently, osteonecrosis of the jaw has been recognized as a potential side effect in patients on long-term bisphosphonate therapy. This condition, popularly called bisphosphonate-related osteonecrosis of the jaw (BRONJ), has been rechristened as MRONJ (medication-related osteonecrosis of the jaw) to accommodate the increasing number of cases of osteonecrosis of jaws associated with various other antiresorptive and antigiogenic pharmacological therapies...
July 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28936298/the-role-of-leucocyte-rich-and-platelet-rich-fibrin-l-prf-in-the-treatment-of-the-medication-related-osteonecrosis-of-the-jaws-mronj
#14
REVIEW
Jorge A Cano-Durán, Juan-Francisco Peña-Cardelles, Daniel Ortega-Concepción, Víctor M Paredes-Rodríguez, Mariano García-Riart, Juan López-Quiles
BACKGROUND: For the treatment of the bisphosphonates and other drugs related osteonecrosis of the jaws, currently medication-related osteonecrosis of the jaws (MRONJ), have been established different conservative therapeutic approaches, avoiding surgery except in cases of extreme need. Given the controversy and lack of current consensus regarding MRONJ therapy in patients, new techniques have been developed among which the use of fibrin membranes rich in platelets and leukocytes (L-PRF)...
August 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28916324/in%C3%A2-vitro-investigation-of-the-antimicrobial-effect-of-three-bisphosphonates-against-different-bacterial-strains
#15
Michael A Ermer, Simon C Kottmann, Jörg-Elard Otten, Annette Wittmer, Philipp Poxleitner, Klaus Pelz
PURPOSE: Since the first descriptions of medication-related osteonecrosis of the jaw (MRONJ) in 2003, the pathogenesis has remained unanswered. Recent histomorphometric studies have found several microorganisms, including Actinomyces, Bacillus, Fusobacterium, Staphylococcus, Streptococcus, Selenomonas, Treponema, and Candida albicans in necrotic bone. Polymerase chain reaction studies have recently confirmed the occurrence of 48 genera. Only a few studies have examined the antimicrobial effect of bisphosphonates (BPs)...
August 31, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28877577/a-case-of-pentastomiasis-at-the-left-maxilla-bone-in-a-patient-with-thyroid-cancer
#16
Eunae Sandra Cho, Seung Wook Jung, Hwi-Dong Jung, In Yong Lee, Tai-Soon Yong, Su Jin Jeong, Hyun Sil Kim
Pentastomiasis, a zoonotic parasite infection, is typically found in the respiratory tract and viscera of the host, including humans. Here, we report for the first time an extremely rare case of intraosseous pentastomiasis in the human maxilla suffering from medication related osteonecrosis of the jaw (MRONJ). A 55-year-old male had continuously visited the hospital for MRONJ which had primarily developed after bisphosphonate and anti-neoplastic administration for previous bone metastasis of medullary thyroid cancer...
August 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28871814/osseous-changes-in-patients-with-medication-related-osteonecrosis-of-the-jaws
#17
Zeynep Burcin Gönen, Canay Yillmaz Asan, Gökmen Zararsiz, Erdem Kiliç, Alper Alkan
OBJECTIVES: Medication-related osteonecrosis of the jaw (MRONJ) is a severe side effect of antiresorptive agents. The aim of this study was to investigate the osseous changes in patients with MRONJ. METHODS: Cone beam CT (CBCT) images of 25 patients with MRONJ and controls were retrospectively evaluated. Buccal, lingual, apical cortical bone thicknesses; buccal, lingual, apical intracortical and cancellous bone density; diameter of mental foramen and incisive canal, and width of mental foramen were measured...
November 1, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28857991/spontaneous-healing-of-clodronate-related-osteonecrosis-of-the-jaw
#18
Enrico Nastro Siniscalchi, Alessandro Allegra, Francesco Saverio De Ponte, Giacomo Oteri, Gabriele Cervino, Floriana Lauritano, Caterina Musolino, Marco Cicciù
Cases of medication-related osteonecrosis of the jaw (MRONJ) have been more commonly associated with aminobiphosphonate therapy than with alkylbiphosphonate treatment. Here, we report a case of MRONJ in a subject who received an alkylbiphosphonate, clodronate, for the treatment of osteoporosis, and discuss the pathogenic mechanisms of alkylbiphosphonates and the possible reasons for the spontaneous and rapid remission of MRONJ occurring in our patient.
October 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28854059/surgical-treatment-of-stage-2-medication-related-osteonecrosis-of-the-jaw-compared-to-osteomyelitis
#19
Sang-Hoon Kang, Yu-Jin Won, Moon-Key Kim
OBJECTIVE: To compare the characteristics and outcomes of patients who underwent surgical treatment for stage 2 medication-related osteonecrosis of the jaw (MRONJ) versus osteomyelitis. METHODS: This retrospective study compared the following variables in 73 patients with stage 2 MRONJ versus 89 patients with osteomyelitis: impaired wound healing after surgery, sex, age, the presence of actinomycosis, location of the jaw lesion, and involvement of the inferior alveolar nerve (IAN)...
August 30, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/28851496/diagnostic-dilemma-between-medication-related-osteonecrosis-and-oral-squamous-cell-carcinoma-in-a-mandibular-lytic-lesion
#20
S Tocaciu, O Breik, B Lim, C Angel, N Rutherford
Osteolytic lesions of the mandible are common, and there are two important differential diagnoses that must be considered: medication-related osteonecrosis of the jaws (MRONJ) and squamous cell carcinoma (SCC). In patients with a history of taking antiresorptive medication as well as risk factors for neoplasia it can be difficult to differentiate between the two. We describe two cases in both of which a mandibular osteolytic lesion was inadequately identified as either MRONJ or SCC because of confusing clinical and histopathological features...
August 26, 2017: British Journal of Oral & Maxillofacial Surgery
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