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https://www.readbyqxmd.com/read/29199704/solitary-pulmonary-nodule-evaluation-in-regions-endemic-for-infectious-diseases-do-regional-variations-impact-the-effectiveness-of-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#1
N C Purandare, C S Pramesh, J P Agarwal, A Agrawal, S Shah, K Prabhash, G Karimundackal, S Jiwnani, S Tandon, V Rangarajan
BACKGROUND: Fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) has become a preferred imaging modality for the evaluation of solitary pulmonary nodule (SPN), particularly in the developed world. Since FDG can concentrate in infective/inflammatory lesions, the diagnostic utility of FDG-PET can be questioned, particularly in regions endemic for infectious decisions. AIM: To evaluate the accuracy of FDG-PET/CT in evaluation of SPNs in a population endemic for infectious disease and to assess if regional variations have an impact on its effectiveness...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29178216/diagnostic-utility-of-surgical-lung-biopsies-in-elderly-patients-with-indeterminate-interstitial-lung-disease
#2
Laszlo T Vaszar, Brandon T Larsen, Karen L Swanson, Jay H Ryu, Henry D Tazelaar
BACKGROUND AND OBJECTIVE: Idiopathic pulmonary fibrosis (IPF) is increasingly diagnosed by clinical and computed tomography (CT) criteria; however, surgical lung biopsy (SLB) may still be required in patients who lack definite CT features of usual interstitial pneumonia (UIP). We reviewed a cohort of elderly patients who underwent SLB, to evaluate the benefit of SLB in diagnosing idiopathic interstitial pneumonia (IIP). METHODS: We searched the pathology records of Mayo Clinic for ambulatory patients at least 75 years old, who underwent SLB between 2000 and 2012 for indeterminate IIP...
November 27, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29156147/electromagnetic-navigational-bronchoscopy-versus-ct-guided-percutaneous-sampling-of-peripheral-indeterminate-pulmonary-nodules-a-cohort-study
#3
Kavita M Bhatt, Yasmeen K Tandon, Ruffin Graham, Charles T Lau, Jason K Lempel, Joseph T Azok, Peter J Mazzone, Erika Schneider, Nancy A Obuchowski, Michael A Bolen
Purpose To compare the diagnostic yield and complication rates of electromagnetic navigational bronchoscopic (ENB)-guided and computed tomography (CT)-guided percutaneous tissue sampling of lung nodules. Materials and Methods Retrospectively identified were 149 patients sampled percutaneously with CT guidance and 146 patients who underwent ENB with transbronchial biopsy of a lung lesion between 2013 and 2015. Clinical data, incidence of complications, and nodule pathologic analyses were assessed through electronic medical record review...
November 20, 2017: Radiology
https://www.readbyqxmd.com/read/29154106/diagnostic-criteria-for-idiopathic-pulmonary-fibrosis-a-fleischner-society-white-paper
#4
REVIEW
David A Lynch, Nicola Sverzellati, William D Travis, Kevin K Brown, Thomas V Colby, Jeffrey R Galvin, Jonathan G Goldin, David M Hansell, Yoshikazu Inoue, Takeshi Johkoh, Andrew G Nicholson, Shandra L Knight, Suhail Raoof, Luca Richeldi, Christopher J Ryerson, Jay H Ryu, Athol U Wells
This Review provides an updated approach to the diagnosis of idiopathic pulmonary fibrosis (IPF), based on a systematic search of the medical literature and the expert opinion of members of the Fleischner Society. A checklist is provided for the clinical evaluation of patients with suspected usual interstitial pneumonia (UIP). The role of CT is expanded to permit diagnosis of IPF without surgical lung biopsy in select cases when CT shows a probable UIP pattern. Additional investigations, including surgical lung biopsy, should be considered in patients with either clinical or CT findings that are indeterminate for IPF...
November 15, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29056601/disagreement-of-diameter-and-volume-measurements-for-pulmonary-nodule-size-estimation-in-ct-lung-cancer-screening
#5
Marjolein A Heuvelmans, Joan E Walter, Rozemarijn Vliegenthart, Peter M A van Ooijen, Geertruida H De Bock, Harry J de Koning, Matthijs Oudkerk
We studied 2240 indeterminate solid nodules (volume 50-500mm(3)) to determine the correlation of diameter and semi-automated volume measurements for pulmonary nodule size estimation. Intra-nodular diameter variation, defined as maximum minus minimum diameter through the nodule's center, varied by 2.8 mm (median, IQR:2.2-3.7 mm), so above the 1.5 mm cutoff for nodule growth used in Lung CT Screening Reporting and Data System (Lung-RADS). Using mean or maximum axial diameter to assess nodule volume led to a substantial mean overestimation of nodule volume of 47...
October 22, 2017: Thorax
https://www.readbyqxmd.com/read/29052526/cardiac-magnetic-resonance-imaging-indeterminate-negative-cardiac-sarcoidosis-revealed-by-18-f-fluorodeoxyglucose-positron-emission-tomography-two-case-reports-and-a-review-of-the-literature
#6
S C Sasson, R Russo, T Chung, G Chu, I Hunyor, J Williamson, A Murad, A Kane, S Riminton, S Limaye
BACKGROUND: Sarcoidosis is an inflammatory disorder of immune dysregulation characterized by non-caseating granulomas that can affect any organ. Cardiac sarcoidosis is an under-recognized entity that has a heterogeneous presentation and may occur independently or with any severity of systemic disease. Diagnosing cardiac sarcoidosis remains problematic with endomyocardial biopsies associated with a high risk of complications. Several diagnostic algorithms are currently available that rely on histopathology or clinical and radiological measures...
October 20, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28969583/italian-tailored-assessment-of-lung-indeterminate-accidental-nodule-by-proposing-a-segmental-pet-computed-tomography-s-pet-ct-rationale-and-study-design-of-a-retrospective-multicenter-trial
#7
Laura Evangelista, Marco Spadafora, Leonardo Pace, Luigi Mansi, Alberto Cuocolo
BACKGROUND: The Italian Tailored Assessment of Lung Indeterminate Accidental Nodule (ITALIAN) is a retrospective, multicenter trial designed to compare the diagnostic information provided by segmental positron emission tomography (PET)/computed tomography (CT) (s-PET/CT) with those of whole body (wb)-PET/CT in patients with single pulmonary nodules (SPN). This report describes the details and implications of the ITALIAN trial design. METHODS AND RESULTS: Between September 2016 and May 2017, 502 consecutive patients (302 men, mean age 67±12 years) with SPN undergoing 18F-fluorodeoxyglucose (FDG) PET/CT were enrolled...
October 2, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28882668/performance-evaluation-of-the-cobas-taqman-mtb-assay-on-respiratory-specimens-according-to-clinical-application
#8
Jong Eun Park, Hee Jae Huh, Won-Jung Koh, Dong Joon Song, Chang-Seok Ki, Nam Yong Lee
OBJECTIVE: To evaluate the performance of the Cobas TaqMan MTB assay (Cobas assay) with respect to its clinical application. METHODS: This was a retrospective analysis of 1154 results from 1034 patients for whom mycobacterial cultures and the Cobas assay were performed simultaneously. Based on the patient medical records, two categories of clinical application were defined: (1) the diagnosis of patients with a high probability of pulmonary tuberculosis according to clinical and radiological features (n=128), and (2) the exclusion of tuberculosis in clinically indeterminate patients (n=1026)...
September 4, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28855041/-growth-evaluation-of-pulmonary-nodules-on-chest-ct
#9
REVIEW
Datong Su, Ying Wang
Computed tomography (CT) follow-up of indeterminate pulmonary nodules and the quantification of growth characteristics are the commonly adopted strategy in clinical setting. The volume/mass doubling time can be used to quantify the growth velocity based on exponential growth model. Therefore, we reviewed the followed aspects on growth evaluation of pulmonary nodules on chest CT, including the growth model of lung cancer, the methods used for nodule growth quantification and the growth characteristics of different types of pulmonary nodules...
August 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28855038/-effect-of-scanning-and-reconstruction-parameters-on-three-dimensional-volume-and-ct-value-measurement-of-pulmonary-nodules-a-phantom-study
#10
Datong Su, Lei Feng, Yingjian Jiang, Ying Wang
BACKGROUND: The computed tomography (CT) follow-up of indeterminate pulmonary nodules aiming to evaluate the change of the volume and CT value is the common strategy in clinic. The CT dose needs to considered on serious CT scans in addition to the measurement accuracy. The purpose of this study is to quantify the precision of pulmonary nodule volumetric measurement and CT value measurement with various tube currents and reconstruction algorithms in a phantom study with dual-energy CT...
August 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28821892/routine-staging-using-chest-computed-tomography-in-workup-of-treatment-na%C3%A3-ve-hepatocellular-carcinoma-prior-to-locoregional-therapy-is-there-a-need
#11
Po Wey Leong, Uei Pua, Kian Soon Lim
INTRODUCTION: The lung is the most common site of distal metastasis in patients with hepatocellular carcinoma (HCC), as seen in more than half of patients with extrahepatic disease. The incidence of pulmonary metastasis in all patients with HCC, however, remains low (between 4.5% to 20%). Their presence, nevertheless, contraindicates curative locoregional therapies. The role of staging chest computed tomography (CT) before locoregional treatment is not well defined. This study aimed to assess the utility of pre-treatment chest CT prior to locoregional therapy...
July 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/28796717/utility-of-flexible-bronchoscopic-cryobiopsy-for-diagnosis-of-diffuse-parenchymal-lung-diseases
#12
Robert J Lentz, Trevor M Taylor, Jonathan A Kropski, Kim L Sandler, Joyce E Johnson, Timothy S Blackwell, Fabien Maldonado, Otis B Rickman
BACKGROUND: Initial reports of transbronchial cryobiopsy for diffuse parenchymal lung disease (DPLD) suggest the diagnostic yield approaches that of surgical lung biopsy (SLB) with an excellent safety profile. Centers performing cryobiopsy differ significantly in procedure technique; an optimal technique minimizing complications but still capable of diagnosing a wide range of DPLDs has not been established. We evaluated our practice of flexible bronchoscopic cryobiopsy in a primarily outpatient setting for patients who required a tissue diagnosis for DPLD of uncertain etiology...
August 7, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28792116/management-of-indeterminate-pulmonary-nodules-1-cm-newly-detected-during-the-follow-up-of-nasopharyngeal-carcinoma-patients
#13
Chengrun Du, Caifeng Wan, Jianhui Ding, Guangyuan Zhang, Youwang Zhang, Chaosu Hu, Hongmei Ying
AIM: To investigate the management for the indeterminate pulmonary nodules newly detected during the follow-up for nasopharyngeal carcinoma (NPC) patients. METHODS: Indeterminate pulmonary lesions were identified by searching medical records of NPC patients, who were followed-up with thoracic CT between April 2008 and February 2014. Indeterminate pulmonary nodules were defined as opacities that may be solitary or multiple, which were <1 cm in size and not calcified...
August 9, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28634123/clinical-utility-of-chromosomal-aneusomy-in-individuals-at-high-risk-of-lung-cancer
#14
Anna E Barón, Severine Kako, William J Feser, Heather Malinowski, Daniel Merrick, Kavita Garg, Stephen Malkoski, Shannon Pretzel, Jill M Siegfried, Wilbur A Franklin, York Miller, Holly J Wolf, Marileila Varella-Garcia
INTRODUCTION: Low-dose computed tomography screening for lung cancer has a high false-positive rate with frequent discovery of indeterminate pulmonary nodules. Noninvasive biomarkers are needed to reduce false positives and improve risk stratification. A retrospective longitudinal evaluation was performed to assess chromosomal aneusomy in sputum by fluorescence in situ hybridization (CA-FISH) in four nested case-control studies. METHODS: Receiver operating characteristic analysis resulted in two grouped cohorts: a high-risk cohort (Colorado High-Risk Cohort and Colorado Nodule Cohort [68 case patients and 69 controls]) and a screening cohort (American College of Radiology Imaging Network/National Lung Screening Trial and Pittsburgh Lung Screening Study [97 case patients and 185 controls])...
October 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28633156/generalized-indeterminate-cell-histiocytosis-presenting-as-eroded-papules-and-crusts
#15
Yaping Li, Harrison Xiao Bai, Chang Su, Guiying Zhang
Indeterminate cell histiocytosis (ICH) is a very rare histiocytic disease. We reported a case of generalized ICH presenting as eroded papules and crusts, accompanied with intermittent fever, pulmonary disorder, lymphadenectasis in the mediastinum, and the retroperitoneum. The histopathology indicated a neoplasm that was composed of small nests of large cells with ample pale cytoplasm. Immunohistochemistry results and the absence of Birbeck granules led us to the diagnosis of ICH. Four months later, the patient died of anemia, ascites, and swelling of the limbs...
July 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28616240/metastatic-pancreatic-carcinoma-masquerading-as-cystic-lung-disease-a-rare-presentation
#16
Emily Stern, Taha Huseini, YiJin Kuok, Fiona Lake
This 52-year-old male ex-smoker presented with a six-month history of progressive breathlessness and weight loss. He deteriorated acutely, and was admitted with severe type 1 respiratory failure. Apart from diffuse coarse crackles on chest auscultation, physical examination was unremarkable. High-resolution computed tomography (HRCT) showed diffuse cystic changes throughout the lungs. A diagnosis of pulmonary Langerhans cell histiocytosis (PLCH) was considered. Further workup identified a coincidental pancreatic lesion of uncertain significance, which remained indeterminate on magnetic resonance imaging (MRI) and on positron emission tomography (PET)...
September 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28583632/alternative-imaging-strategy-of-solitary-pulmonary-nodule-by-fdg-pet-ct-can-be-imagined-a-tailored-pet
#17
Marco Spadafora, Laura Evangelista, Cesare Gridelli, Alberto Cuocolo
OBJECTIVE: Patients with solitary pulmonary nodule (SPN) are usually sent to total-body positron emission tomography/computed tomography (PET/CT) examination with 18F-fluorodeoxyglucose (FDG). However, a segmental scan strategy may improve cost/effectiveness in this category of patients. CONCLUSION: A segmental PET/CT scan only at the chest level could be performed in patients with indeterminate SPN. Limiting the PET/CT field to the thoracic region would greatly affect on radiobiology, department organization and health-care costs...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28580707/a-classifier-integrating-plasma-biomarkers-and-radiological-characteristics-for-distinguishing-malignant-from-benign-pulmonary-nodules
#18
Yanli Lin, Qixin Leng, Zhengran Jiang, Maria A Guarnera, Yun Zhou, Xueqi Chen, Heping Wang, Wenxian Zhou, Ling Cai, HongBin Fang, Jie Li, Hairong Jin, Linghui Wang, Shaoqiong Yi, Wei Lu, David Evers, Carol B Fowle, Yun Su, Feng Jiang
Lung cancer is primarily caused by cigarette smoking and the leading cancer killer in the USA and across the world. Early detection of lung cancer by low-dose CT (LDCT) can reduce the mortality. However, LDCT dramatically increases the number of indeterminate pulmonary nodules (PNs), leading to overdiagnosis. Having a definitive preoperative diagnosis of malignant PNs is clinically important. Using microarray and droplet digital PCR to directly profile plasma miRNA expressions of 135 patients with PNs, we identified 11 plasma miRNAs that displayed a significant difference between patients with malignant versus benign PNs...
September 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28562755/evaluating-respiratory-musculature-quality-of-life-anxiety-and-depression-among-patients-with-indeterminate-chronic-chagas-disease-and-symptoms-of-pulmonary-hypertension
#19
Alícia Cristina Suman, Érika Alessandra Pellison Nunes da Costa, Silméia Garcia Zanati Bazan, João Carlos Hueb, Fabio Cardoso de Carvalho, Luis Cuadrado Martin, Hugo Hyung Bok Yoo
INTRODUCTION: Chagas disease (CD) is progressive and incapacitating, especially when cardiopulmonary function is affected. For example, respiratory muscle weakness can cause dyspnea upon exertion and fatigue, which may be exacerbated when it is associated with pulmonary hypertension (PH). The present study aimed to evaluate respiratory musculature, quality of life, anxiety, and depression among patients with indeterminate chronic CD and symptoms of PH. METHODS: All individuals completed a clinical evaluation, spirometry, a 6-min walking test, respiratory musculature testing using maximum inspiratory pressure (PImax) and maximum expiratory pressure (PEmax), the Hospital Anxiety and Depression Scale, and the SF-36 questionnaire...
March 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28562376/ventilation-perfusion-single-photon-emission-computed-tomography-a-service-evaluation
#20
Amit Parekh, Richard Graham, Stewart Redman
OBJECTIVES: To identify the positive rate and negative predictive value (NPV) of our ventilation/perfusion (V/Q) single-photon emission computed tomography (SPECT) service as respective markers of overcalling (false positives) and undercalling (false negatives). We also identified the indeterminate rate as an indicator of the technical quality of the scans and reporter confidence. PATIENTS AND METHODS: V/Q SPECT studies carried out over 5 years were classified into positive, negative and indeterminate results...
August 2017: Nuclear Medicine Communications
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