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Indeterminate pulmonary

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https://www.readbyqxmd.com/read/29877715/ct-bronchus-sign-and-the-diagnostic-yield-of-guided-bronchoscopy-for-peripheral-pulmonary-lesions-a-systematic-review-and-meta-analysis
#1
Muhammad S Ali, Jaskaran Sethi, Amit Taneja, Ali Musani, Fabien Maldonado
RATIONALE: Indeterminate peripheral pulmonary lesions often require tissue diagnosis. If non-surgical biopsy techniques are considered, deciding between bronchoscopic transbronchial vs. CT guided transthoracic biopsy can be difficult. The former has a low diagnostic yield with a low complication risk, while the latter has a better diagnostic yield but a higher complication rate. Investigators have looked at various lesion characteristics that can predict the diagnostic yield of guided bronchoscopic biopsies...
June 7, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29769130/diagnostic-accuracy-of-low-dose-dual-source-cardiac-computed-tomography-as-compared-to-surgery-in-univentricular-heart-patients
#2
Narumol Chaosuwannakit, Pattarapong Makarawate
BACKGROUND: To evaluate the ability of low radiation dose dual-source computed tomography (DSCT) to depict the features of morphological univentricular heart and to define accuracy by comparing findings with surgery. METHODS: Low radiation dose dual-source cardiac computed tomography (CCT) of 33 cases of functional univentricular heart preliminary diagnosis by echocardiography compared with the results of surgery were retrospectively analyzed (aged 1 day to 4 years, median 5 months)...
May 16, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29758038/novel-high-resolution-computed-tomography-based-radiomic-classifier-for-screen-identified-pulmonary-nodules-in-the-national-lung-screening-trial
#3
Tobias Peikert, Fenghai Duan, Srinivasan Rajagopalan, Ronald A Karwoski, Ryan Clay, Richard A Robb, Ziling Qin, JoRean Sicks, Brian J Bartholmai, Fabien Maldonado
PURPOSE: Optimization of the clinical management of screen-detected lung nodules is needed to avoid unnecessary diagnostic interventions. Herein we demonstrate the potential value of a novel radiomics-based approach for the classification of screen-detected indeterminate nodules. MATERIAL AND METHODS: Independent quantitative variables assessing various radiologic nodule features such as sphericity, flatness, elongation, spiculation, lobulation and curvature were developed from the NLST dataset using 726 indeterminate nodules (all ≥ 7 mm, benign, n = 318 and malignant, n = 408)...
2018: PloS One
https://www.readbyqxmd.com/read/29736699/performance-of-fdg-pet-ct-in-solitary-pulmonary-nodule-based-on-pre-test-likelihood-of-malignancy-results-from-the-italian-retrospective-multicenter-trial
#4
Laura Evangelista, Alberto Cuocolo, Leonardo Pace, Luigi Mansi, Silvana Del Vecchio, Paolo Miletto, Silvia Sanfilippo, Sara Pellegrino, Luca Guerra, Giovanna Pepe, Giuseppina Peluso, Marco Salvatore, Rosj Galicchio, Michele Zuffante, Salvatore Annunziata, Mohsen Farsad, Agostino Chiaravalloti, Marco Spadafora
PURPOSE: The aim of this study was to determine the performance of 18 F-FDG-PET/CT in patients with solitary pulmonary nodule (SPN), stratifying the risk according to the likelihood of pulmonary malignancy. METHODS: FDG-PET/CT of 502 patients, stratified for pre-test cancer risk, were retrospectively analyzed. FDG uptake in SPN was assessed by a 4-point scoring system and semiquantitative analysis using the ratio between SUVmax in SPN and SUVmean in mediastinal blood pool (BP) and between SUVmax in SPN and SUVmean in liver (L)...
May 7, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29730697/risk-related-18-f-fdg-pet-ct-and-new-diagnostic-strategies-in-patients-with-solitary-pulmonary-nodule-the-italian-multicenter-trial
#5
Marco Spadafora, Leonardo Pace, Laura Evangelista, Luigi Mansi, Francesco Del Prete, Giorgio Saladini, Paolo Miletto, Stefano Fanti, Silvana Del Vecchio, Luca Guerra, Giovanna Pepe, Giuseppina Peluso, Emanuele Nicolai, Giovanni Storto, Marco Ferdeghini, Alessandro Giordano, Mohsen Farsad, Orazio Schillaci, Cesare Gridelli, Alberto Cuocolo
PURPOSE: Diagnosis of solitary pulmonary nodule (SPN) is an important public health issue and 18 F-FDG PET/CT has proven to be more effective than CT alone. Pre-test risk stratification and clinical presentation of SPN could affect the diagnostic strategy. A relevant issue is whether thoracic segmental (s)-PET/CT could be implemented in patients with SPN. This retrospective multicenter study compared the results of FDG whole-body (wb)-PET/CT to those of s-PET/CT. METHODS: 18 F-FDG PET/CT of 502 patients, stratified for pre-test cancer risk, were retrospectively analyzed...
May 5, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29727820/main-components-of-pm-10-in-an-area-influenced-by-a-cement-plant-in-catalonia-spain-seasonal-and-daily-variations
#6
Joaquim Rovira, Jordi Sierra, Martí Nadal, Marta Schuhmacher, José L Domingo
Particulate matter (PM) composition has a key role in a wide range of health outcomes, such as asthma, chronic obstructive pulmonary disease, lung cancer, cardiovascular disease, and death, among others. Montcada i Reixac, a municipality located in the Barcelona metropolitan area (Catalonia, Spain), for its location and orography, is an interesting case- study to investigate air pollution. The area is also characterized by the presence of different industrial emission sources, including a cement factory and a large waste management plant, as well as an intense traffic...
May 1, 2018: Environmental Research
https://www.readbyqxmd.com/read/29674403/unexpected-case-of-pneumomediastinum-and-subcutaneous-emphysema-primary-or-secondary-aetiology
#7
Amanda J L Cheng, Timothy J Sadler
A 77-year-old man was admitted with a relapse of antineutrophil cytoplasmic antibody-positive vasculitis with pulmonary involvement and acute kidney injury. There was a background of pulmonary fibrosis (non-specific interstitial pneumonia type pattern) and superadded pulmonary haemorrhage, acute pulmonary oedema and sepsis. The patient was intubated for 4 days and remained dependent on high flow oxygen and continuous positive airway pressure after extubation. A chest radiograph performed 2 weeks after extubation demonstrated unexpected, extensive pneumomediastinum and subcutaneous emphysema...
April 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29656111/circulating-histocompatibility-antigen-hla-gene-products-may-help-differentiate-benign-from-malignant-indeterminate-pulmonary-lesions
#8
Smriti Kanangat, Christopher W Seder, Melissa R Pergande, Gabriela C Lobato, Cristina L Fhied, Maryam F Raouf, Michael J Liptay, Jeffrey A Borgia
BACKGROUND: This study explores the potential diagnostic utility of soluble Human Leukocyte Antigen (sHLA) molecules differentially released by lung adenocarcinoma and benign lung lesions. METHODS: Conditioned media from the NSCLC cell lines H358 and H1703 were immunoblotted for soluble isoforms of major histocompatibility complex (MHC) class I (ABC) and II (DRB1, DMB, and DQ) antigens. Sera from 25 patients with benign and 25 patients with malignant lesions were similarly evaluated to appraise the potential diagnostic value...
April 12, 2018: Human Immunology
https://www.readbyqxmd.com/read/29651163/prospective-comparison-of-qft-git-and-t-spot-tb-assays-for-diagnosis-of-active-tuberculosis
#9
Fengjiao Du, Li Xie, Yonghong Zhang, Fei Gao, Huibin Zhang, Wei Chen, Bingqi Sun, Wei Sha, Yong Fang, Hongyan Jia, Aiying Xing, Boping Du, Li Zheng, Mengqiu Gao, Zongde Zhang
T-SPOT.TB and QuantiFERON-TB Gold In-Tube (QFT-GIT) tests, as two commercial blood assays for diagnosing active tuberculosis (ATB), are not yet fully validated. Especially, there are no reports on comparing the efficacy between the two tests in the same population in China. A multicenter, prospective comparison study was undertaken at four hospitals specializing in pulmonary diseases. A total of 746 suspected pulmonary TB were enrolled and categorized, including 185 confirmed TB, 298 probable TB and 263 non-TB...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29622073/lung-cancer-biopsies
#10
REVIEW
Amita Sharma, Jo-Anne O Shepard
Image-guided percutaneous transthoracic needle biopsy (PTNB) is a well-established and minimally invasive technique for evaluating pulmonary nodules. Implementation of a national lung screening program and increased use of chest computed tomography have contributed to the frequent identification of indeterminate pulmonary nodules that may require tissue sampling. The advent of biomarker-driven lung cancer therapy has led to increased use of repeat PTNB after diagnosis. Percutaneous insertion of markers for preoperative localization of small nodules can aid in minimally invasive surgery and radiation treatment planning...
May 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/29571806/pulmonary-nodules-assessing-the-imaging-biomarkers-of-malignancy-in-a-coffee-break
#11
A Talwar, J M Y Willaime, L C Pickup, M Enescu, D Boukerroui, W Hickes, N M Rahman, M J Gooding, T Kadir, F V Gleeson
INTRODUCTION: Although nodule volumetry is a recognized biomarker of malignancy in pulmonary nodules (PNs), caution is needed in its interpretation because of variables such as respiratory volume variation and inter-scan variability of up to 25%. CT Texture Analysis (CTTA) is a potential independent biomarker of malignancy but inter-scan variability and respiratory volume variation has not been assessed. METHODS: In this prospective cohort study, 40 patients (20 with an indeterminate PN and 20 with pulmonary metastases) underwent two LDCTs within a 60-min period (the "Coffee-break") with the aim of assessing the repeatability of CTTA and semi-automated volume measurements...
April 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29547052/ct-pathologic-correlation-of-major-types-of-pulmonary-fibrosis-insights-for-revisions-to-current-guidelines
#12
Jonathan H Chung, Justin M Oldham, Steven M Montner, Rekha Vij, Ayodeji Adegunsoye, Aliya N Husain, Imre Noth, David A Lynch, Mary E Strek
OBJECTIVE: The purpose of this study was to assess the diagnostic significance of CT patterns that cannot be classified according to current idiopathic pulmonary fibrosis (IPF) guidelines and of specific findings of the inconsistent with usual interstitial pneumonitis (UIP) pattern. MATERIALS AND METHODS: Subjects with a multidisciplinary diagnosis of interstitial lung disease who had undergone surgical lung biopsy and chest CT within 1 year of each other were included in the study...
May 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29525458/ultrasound-guided-percutaneous-needle-biopsy-for-peripheral-pulmonary-lesions-diagnostic-accuracy-and-influencing-factors
#13
Yu-Qing Guo, Xin-Hong Liao, Zhi-Xian Li, Yuan-Yuan Chen, Si-Da Wang, Ji-Han Wang, Xian-Shan Liao, Yuan Luo
A retrospective study was carried out to evaluate the diagnostic accuracy and the factors influencing the diagnostic accuracy of 648 procedures of ultrasound-guided percutaneous needle biopsy (PNB) for peripheral pulmonary lesions (PPLs). We reviewed the histopathology results, the clinical records and the procedure reports of these 648 biopsies and the final diagnoses of 637 PPLs to determine the diagnostic accuracy of ultrasound-guided PNB. Factors that influenced the diagnostic accuracy were assessed by analysis of the biopsy procedures, which were classified as diagnostic cases (true-positive and true-negative) and non-diagnostic cases (false-positive, false-negative and indeterminate)...
May 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29464077/complement-c4d-specific-antibodies-for-the-diagnosis-of-lung-cancer
#14
Daniel Ajona, Marcin Okrój, María J Pajares, Jackeline Agorreta, María D Lozano, Javier J Zulueta, Carla Verri, Luca Roz, Gabriella Sozzi, Ugo Pastorino, Pierre P Massion, Luis M Montuenga, Anna M Blom, Ruben Pio
Development of molecular markers that help to identify high-risk individuals or diagnose indeterminate pulmonary nodules could have a major impact on lung cancer clinical management. In this study, we evaluated the diagnostic potential of a newly-developed ELISA that specifically detects complement C4d. We measured this marker in five independent cohorts of plasma and bronchoalveolar lavage samples from lung cancer patients and controls. In case-control studies, the area under the ROC curve for the diagnosis of lung cancer was 0...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29457270/clinical-and-echocardiographic-characteristics-of-patients-in-sinus-rhythm-normal-left-ventricular-function-and-indeterminate-diastolic-function
#15
Matan Shimron, Lynne Williams, Yevgeni Hazanov, Diab Ghanim, Wadia Kinany, Offer Amir, Shemy Carasso
BACKGROUND: Diastolic dysfunction (DDFx) is the major underlying mechanism of heart failure with preserved left ventricular ejection fraction (EF). Yet, the echocardiographic diagnosis of DDFx in patients in sinus rhythm is challenging and up to 25% of studies have discrepant measures making assessment of DDFx indeterminate. We aimed to describe the clinical and echocardiographic characteristics of patients with indeterminate diastolic function compared to patients with definite normal and abnormal diastolic function...
February 19, 2018: Echocardiography
https://www.readbyqxmd.com/read/29432343/clinical-impact-of-radioguided-localization-in-the-treatment-of-solitary-pulmonary-nodule-a-20-year-retrospective-analysis
#16
Gianpiero Manca, Federico Davini, Elisa Tardelli, Annalisa De Liperi, Fabio Falaschi, Franca Melfi, Patrick M Colletti, Domenico Rubello, Duccio Volterrani, Giuseppe Boni
PURPOSE: Incidental solitary pulmonary nodules (SPNs) have become an increasingly common CT finding worldwide. Although there are currently many imaging strategies for evaluating SPNs, the differential diagnosis and management of SPNs remains complex because of overlap between benign and malignant processes. Moreover, transbronchial or percutaneous CT-guided biopsies do not always allow definitive diagnoses. In such cases, video-assisted thoracic surgery (VATS) has become the preferred surgical procedure for diagnosis and, in selected cases, for treatment of indeterminate SPNs...
May 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29419477/imaging-for-pulmonary-embolism-in-sickle-cell-disease-a-17-year-experience
#17
Patrick Tivnan, Henny H Billett, Leonard M Freeman, Linda B Haramati
Sickle cell disease, a complex disorder with known pulmonary complications, has the potential to confound the diagnosis of pulmonary embolism. We hypothesized that when the choice of imaging is guided by chest radiographic results, CT pulmonary angiography (CTPA) and Ventilation-Perfusion (V/Q) scintigraphy have comparable diagnostic performance in sickle cell disease. Methods: A retrospective cohort of adults with sickle cell disease who were imaged for suspected pulmonary embolism with either CTPA or V/Q, from 2000-2016, at our institution, was established...
February 1, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29381684/indeterminate-nodules-in-osteosarcoma-what-s-the-follow-up
#18
K M Ghosh, L H Lee, T B Beckingsale, C H Gerrand, K S Rankin
BACKGROUND: Indeterminate pulmonary nodules in patients diagnosed with osteosarcoma present a challenge for accurate staging and prognosis. The aim of this study was to explore the significance of this finding. METHODS: A retrospective cohort study of 120 patients with osteosarcoma was performed in the North East of England. Chest computed tomographies (CTs) at presentation were reviewed and the incidence of 'indeterminate' nodules recorded. Follow-up scans were reviewed and survival as well as prognostic features were analysed...
March 6, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29337091/a-clinically-meaningful-interpretation-of-the-prospective-investigation-of-pulmonary-embolism-diagnosis-pioped-ii-and-iii-data
#19
Paul Cronin, Ben A Dwamena
RATIONALE AND OBJECTIVES: This study aimed to calculate the multiple-level likelihood ratios (LRs) and posttest probabilities for a positive, indeterminate, or negative test result for multidetector computed tomography pulmonary angiography (MDCTPA) ± computed tomography venography (CTV) and magnetic resonance pulmonary angiography (MRPA) ± magnetic resonance venography (MRV) for each clinical probability level (two-, three-, and four-level) for the nine most commonly used clinical prediction rules (CPRs) (Wells, Geneva, Miniati, and Charlotte)...
January 11, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29337086/incidental-pulmonary-nodules-are-common-on-ct-coronary-angiogram-and-have-a-significant-cost-impact
#20
James Robertson, Sandra Nicholls, Philip Bardin, Ronnie Ptasznik, Daniel Steinfort, Alistair Miller
BACKGROUND: Computed tomography (CT) coronary angiogram (CTCA) is commonly used for diagnostic evaluation of low-moderate risk patients due to its excellent performance and cost-effectiveness. However, previous cost analyses have not factored in the burden of management of pulmonary nodules, which are a common occurrence. We sought to describe the frequency and characteristics of lung nodules on CTCA in an Australian tertiary hospital, and to assess cost impacts. METHODS: Consecutive CTCAs performed in the calendar year 2012 were retrospectively identified from the imaging department database...
December 5, 2017: Heart, Lung & Circulation
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