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https://www.readbyqxmd.com/read/28182730/68ga-dotatate-pet-ct-imaging-of-indeterminate-pulmonary-nodules-and-lung-cancer
#1
Ronald Walker, Stephen Deppen, Gary Smith, Chanjuan Shi, Jonathan Lehman, Jeff Clanton, Brandon Moore, Rena Burns, Eric L Grogan, Pierre P Massion
PURPOSE: 18F-FDG PET/CT is widely used to evaluate indeterminate pulmonary nodules (IPNs). False positive results occur, especially from active granulomatous nodules. A PET-based imaging agent with superior specificity to 18F-FDG for IPNs, is badly needed, especially in areas of endemic granulomatous nodules. Somatostatin receptors (SSTR) are expressed in many malignant cells including small cell and non-small cell lung cancers (NSCLCs). 68Ga-DOTATATE, a positron emitter labeled somatostatin analog, combined with PET/CT imaging, may improve the diagnosis of IPNs over 18F-FDG by reducing false positives...
2017: PloS One
https://www.readbyqxmd.com/read/28126538/rethinking-autoantibody-signature-panels-for-cancer-diagnosis-a-brief-report
#2
Michael J Campa, Elizabeth B Gottlin, James E Herndon, Edward F Patz
INTRODUCTION: Most pulmonary nodules found on imaging studies are indeterminate, but because of the concern for lung cancer, all patients require further evaluation with resultant radiation risk, significant cost and delays in diagnosis. We hypothesized that a diagnostic blood test based on detection of autoantibodies against cancer antigens would be able to distinguish a benign nodule from lung cancer. METHODS: We identified a panel of 25 serum autoantibodies associated with NSCLC and constructed a protein microarray containing the autoantigens...
January 23, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28125150/phenotypes-of-asthma-in-low-income-children-and-adolescents-cluster-analysis
#3
Anna Lucia Barros Cabral, Andrey Wirgues Sousa, Felipe Augusto Rodrigues Mendes, Celso Ricardo Fernandes de Carvalho
Objective: Studies characterizing asthma phenotypes have predominantly included adults or have involved children and adolescents in developed countries. Therefore, their applicability in other populations, such as those of developing countries, remains indeterminate. Our objective was to determine how low-income children and adolescents with asthma in Brazil are distributed across a cluster analysis. Methods: We included 306 children and adolescents (6-18 years of age) with a clinical diagnosis of asthma and under medical treatment for at least one year of follow-up...
January 23, 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28079759/the-quantiferon-tb-gold-in-tube-assay-in-neuro-ophthalmology
#4
Leanne M Little, Mohammed Rigi, Ayman Suleiman, Stacy V Smith, Edward A Graviss, Rod Foroozan, Andrew G Lee
BACKGROUND: Although QuantiFERON-TB Gold In-Tube (QFT-GIT) testing is regularly used to detect infection with Mycobacterium tuberculosis, its utility in a patient population with a low risk for tuberculosis (TB) has been questioned. The following is a cohort study analyzing the efficacy of QFT-GIT testing as a method for detection of active TB disease in low-risk individuals in a neuro-ophthalmologic setting. METHODS: Ninety-nine patients from 2 neuro-ophthalmology centers were identified as having undergone QFT-GIT testing between January 2012 and February 2016...
January 11, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28066672/intraoperative-molecular-imaging-to-identify-lung-adenocarcinomas
#5
REVIEW
Andrew D Newton, Gregory T Kennedy, Jarrod D Predina, Philip S Low, Sunil Singhal
Intraoperative molecular imaging is a promising new technology with numerous applications in lung cancer surgery. Accurate identification of small nodules and assessment of tumor margins are two challenges in pulmonary resections for cancer, particularly with increasing use of video-assisted thoracoscopic surgery (VATS). One potential solution to these problems is intraoperative use of a fluorescent contrast agent to improve detection of cancer cells. This technology requires both a targeted fluorescent dye that will selectively accumulate in cancer cells and a specialized imaging system to detect the cells...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28042893/the-experiences-of-myocardial-infarction-patients-readmitted-within-six-months-of-primary-percutaneous-coronary-intervention
#6
H Iles-Smith, C Deaton, M Campbell, C Mercer, L McGowan
AIM AND OBJECTIVES: This study explored the experiences of patients readmitted due to potential ischaemic heart disease (p-IHD) symptoms within 6 months of Primary Percutaneous Coronary Intervention (PPCI). BACKGROUND: Following myocardial infarction (MI) and PPCI, some patients experience p-IHD symptoms that may lead to readmission. Symptoms may be related to cardiac ischaemia, reduced psychological health or a comorbid condition. DESIGN: A qualitative study involving semi-structured, in-depth interviews conducted once, mean 196 (50 to 384) days following readmission (at least 6 months following original STEMI and PPCI)...
January 2, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28024694/the-diagnostic-performance-of-routinely-acquired-and-reported-computed-tomography-imaging-in-patients-presenting-with-suspected-pleural-malignancy
#7
Selina Tsim, David B Stobo, Laura Alexander, Caroline Kelly, Kevin G Blyth
OBJECTIVES: Contrast-enhanced computed tomography (CT) provides essential cross-sectional imaging data in patients with suspected pleural malignancy (PM). The performance of CT in routine practice may be lower than in previously reported research. We assessed this relative to 'real-life' factors including use of early arterial-phase contrast enhancement (by CT pulmonary angiography (CTPA)) and non-specialist radiology reporting. MATERIALS AND METHODS: Routinely acquired and reported CT scans in patients recruited to the DIAPHRAGM study (a prospective, multi-centre observational study of mesothelioma biomarkers) between January 2014 and April 2016 were retrospectively reviewed...
January 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27977536/incidence-of-a-single-subsegmental-mismatched-perfusion-defect-in-single-photon-emission-computed-tomography-and-planar-ventilation-perfusion-scans
#8
Matthew Stubbs, Kenneth Chan, Helena McMeekin, Shaunak Navalkissoor, Thomas Wagner
OBJECTIVE: This study aims to compare the incidence of ventilation/perfusion (V/Q) scans interpreted as indeterminate for the diagnosis of pulmonary embolism (PE) using single-photon emission computed tomography (SPECT) versus planar scintigraphy and to consider the effect of variable interpretation of single subsegmental V/Q mismatch (SSM). METHODS: A total of 1300 consecutive V/Q scans were retrospectively reviewed. After exclusion and matching for age and sex, 542 SPECT and 589 planar scans were included in the analysis...
February 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27957506/use-of-nucleic-acid-amplification-tests-in-tuberculosis-patients-in-california-2010-2013
#9
Gianna Peralta, Pennan Barry, Lisa Pascopella
BACKGROUND: Nucleic acid amplification tests (NAATs) have been used as a diagnostic tool for tuberculosis (TB) in the United States for many years. We sought to assess NAAT use in TB patients in California during a period of time when NAAT availability increased throughout the world. METHODS: We conducted a retrospective review of surveillance data from 6051 patients with culture-confirmed pulmonary TB who were reported to the California TB registry during 2010-2013...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27942595/single-cell-rna-sequencing-identifies-diverse-roles-of-epithelial-cells-in-idiopathic-pulmonary-fibrosis
#10
Yan Xu, Takako Mizuno, Anusha Sridharan, Yina Du, Minzhe Guo, Jie Tang, Kathryn A Wikenheiser-Brokamp, Anne-Karina T Perl, Vincent A Funari, Jason J Gokey, Barry R Stripp, Jeffrey A Whitsett
Idiopathic pulmonary fibrosis (IPF) is a lethal interstitial lung disease characterized by airway remodeling, inflammation, alveolar destruction, and fibrosis. We utilized single-cell RNA sequencing (scRNA-seq) to identify epithelial cell types and associated biological processes involved in the pathogenesis of IPF. Transcriptomic analysis of normal human lung epithelial cells defined gene expression patterns associated with highly differentiated alveolar type 2 (AT2) cells, indicated by enrichment of RNAs critical for surfactant homeostasis...
December 8, 2016: JCI Insight
https://www.readbyqxmd.com/read/27911922/nucleic-acid-amplification-testing-and-sequencing-combined-with-acid-fast-staining-in-needle-biopsy-lung-tissues-for-the-diagnosis-of-smear-negative-pulmonary-tuberculosis
#11
Faming Jiang, Weiwei Huang, Ye Wang, Panwen Tian, Xuerong Chen, Zongan Liang
BACKGROUND: Smear-negative pulmonary tuberculosis (PTB) is common and difficult to diagnose. In this study, we investigated the diagnostic value of nucleic acid amplification testing and sequencing combined with acid-fast bacteria (AFB) staining of needle biopsy lung tissues for patients with suspected smear-negative PTB. METHODS: Patients with suspected smear-negative PTB who underwent percutaneous transthoracic needle biopsy between May 1, 2012, and June 30, 2015, were enrolled in this retrospective study...
2016: PloS One
https://www.readbyqxmd.com/read/27889655/a-prediction-model-based-on-biomarkers-and-clinical-characteristics-for-detection-of-lung-cancer-in-pulmonary-nodules
#12
Jie Ma, Maria A Guarnera, Wenxian Zhou, HongBin Fang, Feng Jiang
Lung cancer early detection by low-dose computed tomography (LDCT) can reduce the mortality. However, LDCT increases the number of indeterminate pulmonary nodules (PNs), whereas 95% of the PNs are ultimately false positives. Modalities for specifically distinguishing between malignant and benign PNs are urgently needed. We previously identified a panel of peripheral blood mononucleated cell (PBMC)-miRNA (miRs-19b-3p and -29b-3p) biomarkers for lung cancer. This study aimed to evaluate efficacy of integrating biomarkers and clinical and radiological characteristics of smokers for differentiating malignant from benign PNs...
February 2017: Translational Oncology
https://www.readbyqxmd.com/read/27870823/diagnostic-yield-for-cancer-and-diagnostic-accuracy-of-computed-tomography-guided-core-needle-biopsy-of-subsolid-pulmonary-lesions
#13
Sohaib Munir, Sahil Koppikar, Wilma M Hopman, Alexander H Boag, Gurmohan Dhillon, Shafeequr Rahman Salahudeen, Robert L Nolan, Justin Flood
PURPOSE: We aimed to determine the diagnostic yield for cancer and diagnostic accuracy of computed tomography-guided core needle biopsy (CTNB) in subsolid pulmonary lesions. MATERIALS AND METHODS: Fifty-two biopsies of 52 subsolid lesions in 51 patients were identified from a database of 912 lung biopsies and analyzed for the diagnostic yield for cancer and diagnostic accuracy of core CTNB diagnosis as well as complication rates. RESULTS: When indeterminate biopsy results were included in the analysis, the diagnostic yield for cancer was 80...
January 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/27776653/follow-up-of-ct-derived-airway-wall-thickness-correcting-for-changes-in-inspiration-level-improves-reliability
#14
Esther Pompe, Eva M van Rikxoort, Onno M Mets, Jean-Paul Charbonnier, Jan-Martin Kuhnigk, Harry J de Koning, Matthijs Oudkerk, Rozemarijn Vliegenthart, Pieter Zanen, Jan-Willem J Lammers, Bram van Ginneken, Pim A de Jong, Firdaus A A Mohamed Hoesein
OBJECTIVES: Airway wall thickness (AWT) is affected by changes in lung volume. This study evaluated whether correcting AWT on computed tomography (CT) for differences in inspiration level improves measurement agreement, reliability, and power to detect changes over time. METHODS: Participants of the Dutch-Belgian lung cancer screening trial who underwent 3-month repeat CT for an indeterminate pulmonary nodule were included. AWT on CT was calculated by the square root of the wall area at a theoretical airway with an internal perimeter of 10mm (Pi10)...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27732991/indeterminate-pulmonary-nodules-how-to-minimize-harm
#15
Igor Barjaktarevic, Doug Arenberg, Brandon S Grimes, Kathleen Ruchalski, Denise R Aberle
Each year, more than 1 million persons worldwide are found to have a lung nodule that carries a risk of being malignant. In reality, the vast majority of lung nodules are benign, whether identified by screening or incidentally. The consequences of delaying or missing the diagnosis of lung cancer can be substantial, as can be the consequences of invasive procedures on patients with benign lung nodules. The challenge for the clinician caring for these patients is to differentiate between benign and malignant nodules with the least harm possible...
October 2016: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27689922/yield-of-ct-pulmonary-angiography-in-the-emergency-department-when-providers-override-evidence-based-clinical-decision-support
#16
Zihao Yan, Ivan K Ip, Ali S Raja, Anurag Gupta, Joshua M Kosowsky, Ramin Khorasani
Purpose To determine the frequency of, and yield after, provider overrides of evidence-based clinical decision support (CDS) for ordering computed tomographic (CT) pulmonary angiography in the emergency department (ED). Materials and Methods This HIPAA-compliant, institutional review board-approved study was performed at a tertiary care, academic medical center ED with approximately 60 000 annual visits and included all patients who were suspected of having pulmonary embolism (PE) and who underwent CT pulmonary angiography between January 1, 2011, and August 31, 2013...
March 2017: Radiology
https://www.readbyqxmd.com/read/27648166/enhanced-characterization-of-solid-solitary-pulmonary-nodules-with-bayesian-analysis-based-computer-aided-diagnosis
#17
REVIEW
Simone Perandini, Gian Alberto Soardi, Massimiliano Motton, Raffaele Augelli, Chiara Dallaserra, Gino Puntel, Arianna Rossi, Giuseppe Sala, Manuel Signorini, Laura Spezia, Federico Zamboni, Stefania Montemezzi
The aim of this study was to prospectively assess the accuracy gain of Bayesian analysis-based computer-aided diagnosis (CAD) vs human judgment alone in characterizing solitary pulmonary nodules (SPNs) at computed tomography (CT). The study included 100 randomly selected SPNs with a definitive diagnosis. Nodule features at first and follow-up CT scans as well as clinical data were evaluated individually on a 1 to 5 points risk chart by 7 radiologists, firstly blinded then aware of Bayesian Inference Malignancy Calculator (BIMC) model predictions...
August 28, 2016: World Journal of Radiology
https://www.readbyqxmd.com/read/27616155/diagnostic-and-clinical-utility-of-dynamic-contrast-enhanced-mr-imaging-in-indeterminate-pulmonary-nodules-a-metaanalysis
#18
Binghu Jiang, Huaijun Liu, Dan Zhou
OBJECTIVE: This study aims to perform a metaanalysis to assess the diagnostic performance and clinical utility of the dynamic magnetic resonance imaging (MRI) in discrimination of benign and malignant pulmonary nodules. MATERIALS AND METHODS: We searched PubMed, EMBASE, and Cochrane Library from January 1995 to May 2015 for studies evaluating the diagnostic accuracy of dynamic MRI in discriminating benign from malignant pulmonary nodules. Methodological quality was assessed by the Quality Assessment of Diagnostic Accuracy Studies-2...
November 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27615397/autoantibody-signature-enhances-the-positive-predictive-power-of-computed-tomography-and-nodule-based-risk-models-for-detection-of-lung%C3%A2-cancer
#19
Pierre P Massion, Graham F Healey, Laura J Peek, Lynn Fredericks, Herb F Sewell, Andrea Murray, John F R Robertson
INTRODUCTION: The incidence of pulmonary nodules is increasing with the movement toward screening for lung cancer by low-dose computed tomography. Given the large number of benign nodules detected by computed tomography, an adjunctive test capable of distinguishing malignant from benign nodules would benefit practitioners. The ability of the EarlyCDT-Lung blood test (Oncimmune Ltd., Nottingham, United Kingdom) to make this distinction by measuring autoantibodies to seven tumor-associated antigens was evaluated in a prospective registry...
March 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27610265/the-diagnostic-value-of-serum-c-reactive-protein-for-identifying-pneumonia-in-hospitalized-patients-with-acute-respiratory-symptoms
#20
Agustín Ruiz-González, Laia Utrillo, Silvia Bielsa, Miquel Falguera, José M Porcel
Background. The clinical diagnosis of pneumonia is sometimes difficult since chest radiographs are often indeterminate. In this study, we aimed to assess whether serum C-reactive protein (CRP) could assist in identifying patients with pneumonia. Methods. For one winter, all consecutive patients with acute respiratory symptoms admitted to the emergency ward of a single center were prospectively enrolled. In addition to chest radiographs, basic laboratory tests, and microbiology, serum levels of CRP were measured at entry...
2016: Journal of Biomarkers
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