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Takayasu Ito, Naoki Fujimoto, Eiji Ishikawa, Kaoru Dohi, Mika Fujimoto, Tomohiro Murata, Michiyo Kiyohara, Hideyuki Takeuchi, Sukenari Koyabu, Hiroyuki Nishimura, Toshiaki Takeuchi, Masaaki Ito
BACKGROUND: Intradialytic hypertension (HTN), which is one of the poor prognostic markers in patients undergoing hemodialysis, may be associated with sympathetic overactivity. The L/N-type calcium channel blocker, cilnidipine, has been reported to suppress sympathetic nerves activity in vivo. Therefore, we hypothesized that cilnidipine could attenuate intradialytic systolic blood pressure (SBP) elevation. METHODS: Fifty-one patients on chronic hemodialysis who had intradialytic-HTN (SBP elevation ≥10 mmHg during hemodialysis) and no fluid overload were prospectively randomized into two groups: control and cilnidipine groups...
March 27, 2018: Clinical and Experimental Hypertension: CHE
Rafael Campos, Fabíola Z Mónica, Renata Lopes Rodrigues, Julio Alejandro Rojas-Moscoso, Ronilson Agnaldo Moreno, José Carlos Cogo, Marco Antonio de Oliveira, Edson Antunes, Gilberto De Nucci
Reptiles are the first amniotes to develop an intromitent penis, however until now the mechanisms involved in the electrical field stimulation-induced contraction on corpora cavernosa isolated from Crotalus durissus terrificus were not investigated. Crotalus and rabbit corpora cavernosa were mounted in 10 mL organ baths for isometric tension recording. Electrical field stimulation (EFS)-induced contractions were performed in presence/absence of phentolamine (10 μM), guanethidine (30 μM), tetrodotoxin (1 μM and 1mM), A-803467 (10 μM), 3-iodo-L-Tyrosine (1 mM), salsolinol (3 μM) and a modified Krebs solution (equimolar substitution of NaCl by N-methyl-D-glucamine)...
2017: PloS One
I Bhorat, D P Naidoo, J Moodley
AIM: To establish alterations in maternal cardiac haemodynamics and function using electrocardiography and echocardiography in severe pre-eclampsia complicated by acute pulmonary oedema. METHODS: An extensive literature search including any research articles, randomised control trials, observational study, case report or expert or consensus statement pertaining to severe pre-eclampsia, eclampsia, hypertensive crises of pregnancy, pulmonary oedema, maternal cardiac haemodynamics, Holter monitoring and maternal echocardiography was done...
December 2017: Journal of Maternal-fetal & Neonatal Medicine
Maddalena Botti, Luisa Ragionieri, Antonio Cacchioli, Rino Panu, Ferdinando Gazza
Retrograde neuronal tracing and single labelling immunofluorescence methods were used to define the neurochemical content of the peripheral autonomic and sensitive neurons projecting to the male pig striated bulbospongiosus muscle (BSM). The retrograde fluorescent neuronal tracer Fast Blue (FB) was injected into the left bulbospongiosus muscle of four intact impuberal pigs. After a 10-day survival time, the ipsilateral sacral sympathetic trunk ganglia (STGs), the caudal mesenteric ganglion (CMG), and the sacral spinal ganglia (SGs) were collected from each animal...
September 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Niels Secher, Christian Lind Malte, Else Tønnesen, Leif Østergaard, Asger Granfeldt
Only one in ten patients survives cardiac arrest (CA), underscoring the need to improve CA management. Isoflurane has shown cardio- and neuroprotective effects in animal models of ischemia-reperfusion injury. Therefore, the beneficial effect of isoflurane should be tested in an experimental CA model. We hypothesize that isoflurane anesthesia improves short-term outcome following resuscitation from CA compared with a subcutaneous fentanyl/fluanisone/midazolam anesthesia. Male Sprague-Dawley rats were randomized to anesthesia with isoflurane (n = 11) or fentanyl/fluanisone/midazolam (n = 11)...
November 1, 2017: Journal of Applied Physiology
Ernesto Valero, Eva Rumiz, Mauricio Pellicer
OBJECTIVE: The aim of this case report was to highlight the importance of ruling out pheochromocytoma in a patient with Von Hippel-Lindau disease (VHL) and cardiovascular manifestations. CLINICAL PRESENTATION AND INTERVENTION: A 22-year-old woman with type IIb VHL presented with signs and symptoms of acute decompensated heart failure. Transthoracic echocardiography showed a dilated left ventricle with severely depressed ejection fraction, confirmed by MRI. Urinary catecholamine and metanephrine tests had elevated levels and an abdominal MRI showed the presence of two cystic masses at the left hypochondrium...
2016: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
P Pollesello, Z Papp, J Gy Papp
The use of inotropes for correcting hemodynamic dysfunction in patients with congestive heart failure has been described over many decades. Drugs such as cardiac glycosides, cathecolamines, phosphodiestherase inhibitors, and calcium sensitizers have been in turn proposed. However, the number of new chemical entities in this therapeutic field has been surprisingly low, and the current selection of drugs is limited. One of the paradigm shifts in the discovery for new inotropes was to focus on 'calcium sensitizers' instead of 'calcium mobilizers'...
January 15, 2016: International Journal of Cardiology
M Parasiliti Caprino, B Lucatello, C Bima, V D'Angelo, J Burrello, A Piovesan, A La Grotta, R Giordano, P Mulatero, F Veglio, E Arvat, E Ghigo, M Maccario
OBJECTIVE: Pheochromocytomas and paragangliomas (PPGLs) are rare neoplasms often releasing cathecolamines, mainly originating from adrenals but occasionally observed in sympathetic and parasympathetic ganglia, with a genetic base up to 25% of the cases. After radical surgery of these tumors, disease recurrence was believed to be under 10% but recent studies reported a higher rate even after many years. Apart from familiar forms, little evidence exist about predictors of disease relapse, so we aimed to research predictors of recurrence with a retrospective analysis on patients referred to our Centers from 2000...
June 2015: Journal of Hypertension
Maria Laura De Marchis, Piero Barbanti, Raffaele Palmirotta, Gabriella Egeo, Cinzia Aurilia, Luisa Fofi, Serena Piroso, Cristiano Ialongo, David Della-Morte, Giovanni D'Andrea, Patrizia Ferroni, Fiorella Guadagni
BACKGROUND: The study of COMT gene polymorphisms in migraine could be of particular interest since impaired catecholaminergic neurotransmission, namely chronic dopaminergic and noradrenergic hypofunction, is a peculiar migraine trait. In this study, for the first time, we focused on the role of COMT rs4818 genetic variant, the polymorphism most strongly affecting COMT activity, in migraine. This study was conducted in a cohort of carefully clinical characterized Caucasian migraineurs recruited in a specifically dedicated migraine biobank, providing also a replication study on rs4680 polymorphism...
2015: Journal of Headache and Pain
Michele Umbrello, Marco Gardinali, Davide Ottolina, Giancarlo Zanforlin, Gaetano Iapichino
Background. Systemic capillary leak syndrome (SCLS) is a rare disorder characterized by unexplained, recurrent episodes of transient, abrupt increase in endothelial permeability, leading to severe hypotension, generalized edema, and hemoconcentration. Case Report. We report the case of a patient suffering from systemic capillary leak syndrome and present a possible interpretation of the pathophysiology of this condition. Besides the classical triad of hypotension, edema, and hemoconcentration, we recorded increased levels of methemoglobin, an index of NO overproduction...
2014: Case Reports in Critical Care
Soraya F Habr, Daclé J Macrini, Jorge C Florio, Maria M Bernardi
Deltamethrin (DTM) is a type II pyrethroid insecticide that elicits autonomic and neuroendocrine responses that indicate high levels of stress, presumably caused by the neurotoxic effect of the insecticide. This study investigated the effect of DTM exposure (10 mg/kg, p.o.) and an additional stress induced in the forced swim test (FST) in behavioral tasks related to anxiety, serum corticosterone levels, and striatal neurotransmitter levels. Open field behavior and social interaction were evaluated after DTM administration (10 mg kg(-1), p...
November 2014: Neurotoxicology and Teratology
Ç Yildirim, Ö H Yüksel, A Ürkmez, N Özbay, A Verit
Pheochromocytomas are rarely seen cathecolamine-secreting neuroendocrine tumors. Diagnosis, treatment, and prognosis of this rarely seen condition have been discussed. In this study, a retroperitoneal paraganglioma with a diameter of 27 mm was detected in a 29-years old nephrectomized male patient. In our case, in reevaluations performed after definitive establishment of the diagnosis, any abnormal radiological signs suggesting a metastatic lesion were not detected. During the postoperative period the patient was referred to the clinics of endocrinology, and oncology for medical follow-up...
October 2014: Georgian Medical News
Antonio Noto, Vassilios Fanos, Luigi Barberini, Dmitry Grapov, Claudia Fattuoni, Marco Zaffanello, Andrea Casanova, Gianni Fenu, Andrea De Giacomo, Maria De Angelis, Corrado Moretti, Paola Papoff, Raffaella Ditonno, Ruggiero Francavilla
OBJECTIVE: A supervised multivariate model to classify the metabolome alterations between autistic spectrum disorders (ASD) patients and controls, siblings of autistic patients, has been realized and used to realize a network model of the ASD patients' metabolome. METHODS: In our experiment we propose a quantification of urinary metabolites with the Mass Spectroscopy technique couple to Gas Chromatography. A multivariate model has been used to extrapolate the variables of importance for a network model of interaction between metabolites...
October 2014: Journal of Maternal-fetal & Neonatal Medicine
Iván J Núñez-Gil, Esther Bernardo, Gisela Feltes, Javier Escaned, Hernán D Mejía-Rentería, José Alberto De Agustín, David Vivas, Luis Nombela-Franco, Pilar Jiménez-Quevedo, Carlos Macaya, Antonio Fernández-Ortiz
Takotsubo cardiomyopathy (TK) includes a transient left ventricular dysfunction without obstructive coronary disease, sometimes after stressful situations with elevated cathecolamines. Since catecholamines activate platelets we aimed to study the platelet influence in a TK setting. We included 32 patients with a TK diagnosis, 13 with an acute coronary syndrome (ACS) and 18 healthy volunteers. Once consent informed was obtained, blood samples were extracted and processed (at admission and after 3 months follow-up)...
May 2015: Journal of Thrombosis and Thrombolysis
Daisuke Nakatsuka, Kazuo Yamanaka, Takeshi Nishina, Keiichi Hirose, Jin Ikarashi, Yuki Hori, Daisuke Yasumizu, Yuichi Ueda
We report a case of aortic valve replacement (AVR) and mitral valve replacement (MVR) in a patient with severe left ventricular dysfunction who had undergone right pneumonectomy for lung cancer 14 years previously. A 64-year-old man had cathecolamine-dependent heart failure due to bicuspid aortic valve stenosis, functional mitral valve regurgitation and impaired left ventricular function (left ventricular ejection fraction 13%)because of dilated cardiomyopathy. AVR and MVR were performed using St. Jude Medical mechanical valves with right thoracotomy because the heart had shifted to the right side...
March 2014: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Nicola Ferrara, Klara Komici, Graziamaria Corbi, Gennaro Pagano, Giuseppe Furgi, Carlo Rengo, Grazia D Femminella, Dario Leosco, Domenico Bonaduce
Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle inotropic reserve related to increased vascular afterload, arterial-ventricular load mismatching, physical deconditioning and impaired autonomic regulation (the so called "β-adrenergic desensitization"). Adrenergic responsiveness is altered with aging and the age-related changes are limited to the β-adrenergic receptor density reduction and to the β-adrenoceptor-G-protein(s)-adenylyl cyclase system abnormalities, while the type and level of abnormalities change with species and tissues...
2014: Frontiers in Physiology
Johanna Paronen, Mika Väisänen, Helena Leijon
Pheochromocytoma is a tumor of the chromaffin tissue, originating from the suprarenal medulla and secreting cathecolamines, adrenalin and noradrenalin. Because the symptoms of this rare disease may deceptively resemble those of other diseases, its diagnosis may be delayed. Episodic symptoms are characteristic of pheochromocytoma. In most cases the tumor is curable with surgery, but untreated may lead to sudden death of the patient, or have time to spread. Alpha-blockade is started before the operation. The operations should be concentrated to units specialized in endocrine surgery...
2013: Duodecim; Lääketieteellinen Aikakauskirja
Matteo Lazzaretti, Dora Fabbro, Michela Sala, Kether Del Toso, Giulia de Vidovich, Elisa Marraffini, Niccolò Morandotti, Francesca Gambini, Francesco Barale, Matteo Balestrieri, Giuseppe Damante, Edgardo Caverzasi, Paolo Brambilla
The objective of the present study was to test the association between Borderline Personality Disorder (BPD) and the cathecolamine-O-methyl-transferase (COMT) low-activity (Met158) single nucleotide polymorphism (SNP). In this case-control study, DNA was obtained from venous blood of 19 BPD patients and 36 healthy subjects. COMT-Val158Met single-nucleotide polymorphism was genotyped by predesigned SNP assay. The COMT Met158 allele was over-represented in patients with BPD in comparison to normal subjects (68...
2013: Behavioral Medicine
Carlo Pancaro, Viviane G Nasr, Jessica K Paulus, Iwona Bonney, Alejandro F Flores, Jonas B Galper, Iqbal Ahmed
BACKGROUND: A test dose is used to detect intravascular injection during neuraxial block in pediatrics. Accidental intravascular epidural local anesthetic injection might be unrecognized in anesthetized children leading to potential life-threatening complications. In children, sevoflurane anesthesia blunts the hemodynamic response when intravascular cathecolamines are administered. No studies have explored the hemodynamics and the criteria for a positive test dose result following phenylephrine in sevoflurane anesthetized children...
June 2013: Paediatric Anaesthesia
Giovanni Conzo, Mario Musella, Francesco Corcione, Maurizio De Palma, Fausto Ferraro, Antonietta Palazzo, Salvatore Napolitano, Marco Milone, Daniela Pasquali, Antonio Agostino Sinisi, Vittorio Colantuoni, Luigi Santini
BACKGROUND: Minimally invasive adrenalectomy for pheochromocytoma (PCC) is a complex surgical procedure especially because of the haemodynamic instability due to the excessive secretion of cathecolamines, which may result in a considerable risk of conversion and complications. AIM: By a multicentric retrospective study, the authors reported the results of laparoscopic adrenalectomies in patients operated for adrenal pheochromocytomas with the aim of investigating the role of the laparoscopic approach in managing adrenal disease...
2013: International Journal of Surgery
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