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https://www.readbyqxmd.com/read/29785651/genetic-analysis-of-the-human-insulin-like-3-gene-in-pediatric-patients-with-testicular-torsion
#1
Anna Paola Capra, Elisa Ferro, Maria Angela La Rosa, Silvana Briuglia, Tiziana Russo, Salvatore Arena, Carmelo Salpietro Damiano, Carmelo Romeo, Pietro Impellizzeri
PURPOSE: Testicular torsion (TT) mainly affects boys under 18 years old. To avoid orchiectomy, TT requires an immediate operative management. The etiology of TT is still controversial. Observed familiar recurrence suggests the presence of a genetic involvement. The INSL3 gene consists of two exons, and it is specifically expressed in fetal and adult Leydig cells. In transgenic mice, deletion of this gene was observed an increased testicular mobility and testicular torsion. We have hypothesized the possible involvement of the INSL3 gene as a predisposing factor of human TT...
May 21, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29777790/effect-of-intratesticular-hematoma-on-testis-microstructure-spermatogenesis-and-testosterone-production-defining-a-cut-off-point-for-significant-intratesticular-hematoma
#2
Alireza Aminsharifi, Alireza Monsef, Ali Noorafshan, Saied Karbalay-Doust, Zahra Jafarinezhad, Omid Koohi, Afshin Molaei
OBJECTIVES: To evaluate the effect of different degrees of intratesticular hematoma (ITH), a major consequence of blunt testis trauma, on testis microstructure and function. We determined a cut-off point for significant vs. nonsignificant ITH. METHODS: Seventy male rats were divided into 7 equal groups. The control group (G) remained intact. Sham groups consisted of rats given an intratesticular injection of normal saline in both testicles with volumes equivalent to 40% of testis volume (G-II), 30% (G-III) and 10% (G-IV)...
May 16, 2018: Urology
https://www.readbyqxmd.com/read/29776745/anatomical-histological-and-immunohistochemical-study-of-testicular-development-in-columba-livia-aves-columbiformes
#3
G B Olea, M V Aguirre, D M Lombardo
In this work, testicular ontogeny is analyzed at the anatomical, histological and immunohistochemical levels; the latter through the detection of GnRHR and PCNA in the testicles of embryos, neonates and juveniles of Columba livia. We analyzed 150 embryos, 25 neonates and 5 juveniles by means of observations under a stereoscopic magnifying glass and scanning electron microscope (SEM). The histological analysis was performed using hematoxylin-eosin staining techniques and the PAS reaction. For the immunohistochemical analysis, the expression of GnRHR and PCNA in embryos corresponding to stages 41, 43 and in neonates of 2, 5, 7 and 75 days post-hatch was revealed in testicular histological preparations...
May 16, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29771299/at-the-crossroads-of-fate-somatic-cell-lineage-specification-in-the-fetal-gonad
#4
Emmi Rotgers, Anne Jørgensen, Humphrey Hung-Chang Yao
The reproductive endocrine systems are vastly different between male and female. This sexual dimorphism of endocrine milieu originates from sex-specific differentiation of the somatic cells in the gonads during fetal life. The majority of gonadal somatic cells arise from the adrenogonadal primordium. After separation of the adrenal and gonadal primordia, the gonadal somatic cells initiate sex-specific differentiation during gonadal sex determination with the specification of the supporting cell lineages: Sertoli cells in the testis vs...
May 15, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29770362/study-of-anti-m%C3%A3-llerian-hormone-levels-in-patients-with-myotonic-dystrophy-type-1-preliminary-results
#5
Manuela Ergoli, Massimo Venditti, Raffaele Dotolo, Esther Picillo, Sergio Minucci, Luisa Politano
Myotonic dystrophy type 1 is a multisystemic disorder characterized by myotonia, muscle weakness and involvement of several organs and apparatus such as heart, lungs, eye, brain and endocrine system. Hypogonadism and reproductive abnormalities are frequently reported. A progressive testicular atrophy occurs in about 80% in the affected males leading to Leydig cell hyperproliferation and elevated basal follicle stimulating hormone (FSH) levels. Anti-Müllerian hormone (AMH) - a dimeric glycoprotein belonging to the super-family of transforming grow factor beta (TGF-beta) - is the earliest Sertoli cell hormone secreted in males and, together with inhibin B and FSH, is an important indicator of Sertoli cell function...
December 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/29768980/enhanced-steroidogenic-and-altered-antioxidant-response-by-zno-nanoparticles-in-mouse-testis-leydig-cells
#6
Nisha Bara, Gautam Kaul
Zinc oxide nanoparticles (ZnO NPs) are important nanomaterials with myriad applications and in widespread use. The main aim of this study was to evaluate the direct effect of ZnO NPs on steroidogenesis by considering mouse testicular Leydig cells (TM3) as an in vitro model system. The uptake, intracellular behaviour, cytotoxicity and morphological changes induced by ZnO NPs (0-200 µg/ml) in a time-dependent manner in the TM3 were assessed. A significant ( p < 0.05) decrease in TM3 viability was observed at 2 µg/ml ZnO NP after a 1-h incubation time period...
January 1, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29763586/postnatal-testis-development-in-the-collared-peccary-tayassu-tajacu-with-emphasis-on-spermatogonial-stem-cells-markers-and-niche
#7
Nathália de Lima E Martins Lara, Guilherme Mattos Jardim Costa, Gleide Fernandes de Avelar, Diva Anelie Guimarães, Luiz Renato de França
Collared peccaries (Tayassu tajacu) present a unique testis cytoarchitecture, where Leydig cells (LC) are mainly located in cords around the seminiferous tubules (ST) lobes. This peculiar arrangement is very useful to better investigate and understand the role of LC in spermatogonial stem cells (SSCs) biology and niche. Recent studies from our laboratory using adult peccaries have shown that the undifferentiated type A spermatogonia (Aund or SSCs) are preferentially located in ST regions adjacent to the intertubular compartment without LC...
May 12, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29753783/nicotine-induced-autophagy-of-leydig-cells-rather-than-apoptosis-is-the-major-reason-of-the-decrease-of-serum-testosterone
#8
Xianglong Zhao, Wangjie Xu, Jiajie Wu, Dong Zhang, Abdelrahman Abou-Shakra, Ling Di, Zhaoxia Wang, Lianyun Wang, Fan Yang, Zhongdong Qiao
A new report has shown that nicotine exposure can decrease serum testosterone by apoptosis in Leydig cells; however, in our previous studies, we have almost never observed apoptosis there. The purpose of this study is to ensure whether apoptosis or autophagy in Leydig cells occurred. Our results confirmed again that the concentration of testosterone in the sera of nicotine-treated mice statistically decreased (P < 0.05). Furthermore, the data of single cell transcriptome indicated that the expression of autophagy-related genes was increased after nicotine exposure...
May 10, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29746863/bisphenol-a-elicited-mir-146a-5p-impairs-murine-testicular-steroidogenesis-through-negative-regulation-of-mta3-signaling
#9
Guo-Zheng Gao, Yong Zhao, Hong-Xin Li, Wei Li
The epigenetic effects on expression of non-coding RNAs (e.g. microRNAs) of environmental toxin bisphenol A (BPA) have extended our understanding of the etiology of human reproductive disorders including hypospermatogenesis and androgen deficiency. BPA-induced miR-146a-5p is a potent regulator of endocrine and immune homeostasis, but its role in testis remain unexplored. We show here that in murine testis, miR-146a-5p was exclusively expressed in interstitial Leydig cells (LCs). This expression was significantly induced by BPA exposure...
May 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29744903/effects-of-astaxanthin-on-biochemical-and-histopathological-parameters-related-to-oxidative-stress-on-testes-of-rats-on-high-fructose-regime
#10
E Dokumacioglu, H Iskender, G Yenice, K A T Kapakin, C Sevim, A Hayirli, S Saral, S Comakli
Astaxanthin (ASX) is a xanthophyll family of hydroxycarotenoids which contains several double bonds. It is produced by Haemococcus pluvialis, a microalgae and possesses antioxidant and anti-inflammatory properties. The aim of this study was to test whether ASX could protect against oxidative damage in the testicular tissues of rats receiving high fructose. The rats (n = 24) were randomly divided into two main groups: control and fructose (30%, via drinking water) and then each main group either not supplemented or supplemented with ASX (1 mg kg-1 day-1 , within 0...
May 9, 2018: Andrologia
https://www.readbyqxmd.com/read/29743498/calretinin-participates-in-regulating-steroidogenesis-by-plc-ca-2-pkc-pathway-in-leydig-cells
#11
Wendan Xu, Qian Zhu, Shan Liu, Xiaonan Dai, Bei Zhang, Chao Gao, Li Gao, Jiayin Liu, Yugui Cui
Calretinin, a Ca2+ -binding protein, participates in many cellular events. Our previous studies found the high expression of calretinin in testicular Leydig cells. In this study, (MLTC-1 cells were infected with LV-calb2, R2C cells with LV-siRNA-calb2. The primary mouse Leydig cells were also used to confirm those data from cell lines. Testosterone level was significantly higher in the MLTC-1 cells with over-expressed calretinin than in the control, while progesterone was lower in the R2C cells in which down-regulated calretinin...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29740335/amniotic-fluid-insl3-measured-during-the-critical-time-window-in-human-pregnancy-relates-to-cryptorchidism-hypospadias-and-phthalate-load-a-large-case-control-study
#12
Ravinder Anand-Ivell, Arieh Cohen, Bent Nørgaard-Pedersen, Bo A G Jönsson, Jens-Peter Bonde, David M Hougaard, Christian H Lindh, Gunnar Toft, Morten S Lindhard, Richard Ivell
The period of the first to second trimester transition in human pregnancy represents a sensitive window for fetal organogenesis, particularly in regard to the development of the male reproductive system. This is a time of relative analytical inaccessibility. We have used a large national biobank of amniotic fluid samples collected at routine amniocentesis to determine the impacts of exogenous endocrine disruptor load on specific fetal biomarkers at this critical time. While adrenal and testicular steroids are highly correlated, they are also mostly positively influenced by increasing phthalate load, represented by the metabolites 7cx-MMeHP and 5cx-MEPP, by perfluorooctane sulfonate (PFOS) exposure, and by smoking, suggesting an adrenal stress response...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29739732/inherited-deletion-of-1q-hyperparathyroidism-and-signs-of-y-chromosomal-influence-in-a-patient-with-turner-syndrome
#13
Alejandro F Siller, Alex Shimony, Marwan Shinawi, Ina Amarillo, Louis P Dehner, Katherine Semenkovich, Ana María Arbeláez
We report a detailed phenotypic, cytogenetic, and molecular characterization of a patient diagnosed prenatally with Turner syndrome (TS). In addition to having typical TS clinical characteristics such as a webbed neck, high arched palate, and coarctation of the aorta, the patient had features less frequently seen in TS, including recurrent parathyroid adenomas, growth along the 75th-90th centiles on the TS height curve despite a minimal treatment with growth hormone, behavioral problems, and evidence of gonadal dysgenesis with testicular-like structures, such as seminiferous tubules lined by Sertoli cells and a contiguous nodule of Leydig cells...
May 9, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29737216/thyroid-dysfunction-and-semen-quality
#14
Sandro La Vignera, Roberto Vita
Thyroid hormones act on testis in multiple ways and exert their effect on different cell types, including Leydig and Sertoli cells, and germ cells. An excess or deficit of thyroid hormones results in alterations of testis function, including semen abnormalities. More frequently, hyperthyroidism has been associated with reduced semen volume and reduced sperm density, motility, and morphology, whereas hypothyroidism is associated with reduced sperm morphology. Therefore, thyroid function tests should be part of the diagnostic workup of the infertile man...
January 2018: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29730010/g-protein-coupled-estrogen-receptor-gper-in-adult-boar-testes-epididymis-and-spermatozoa-during-epididymal-maturation
#15
Romana Krejčířová, Marie Maňasová, Veronika Sommerová, Eva Langhamerová, Radko Rajmon, Pavla Maňásková-Postlerová
The G protein-coupled estrogen receptor (GPER) is a transmembrane receptor considered as a mediator of rapid non-genomic responses. GPER has been found in the male reproductive tract of many mammalian species. However, in adult boars, GPER has been reported only in ejaculated spermatozoa. Therefore, we focused on GPER detection in testicular and epididymal tissues and sperm cells in adult boars. We found GPER in Leydig cells and seminiferous tubules of boar testes and in the secretory epithelium of epididymis...
May 3, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29727732/luffa-operculata-fruit-aqueous-extract-induces-motor-impairments-anxiety-like-behavior-and-testis-damage-in-rats
#16
Cinthia Dos S Alves, Humberto V Frias, Thiago B Kirsten, Flora Cordeiro, Maria M Bernardi, Ivana B Suffredini
ETHNOPHARMACOLOGICAL RELEVANCE: Luffa operculata (L.) Cogn., Cucurbitaceae (buchinha-do-norte), aqueous extract (EBN) is popularly used to relieve symptoms of sinusitis and as abortive. AIM OF THE STUDY: As neurotoxicity and toxicity studies on the male reproductive system are scarce, the present study aimed at quantitatively addressing the question. MATERIALS AND METHODS: Male adult rats were observed in the open field (OF) and in the light-dark box test (LDB) to evaluate locomotion and anxiety...
May 1, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29724155/nerve-growth-factor-improves-the-outcome-of-type-2-diabetes-induced-hypotestosteronemia-and-erectile-dysfunction
#17
Yixing Wu, Chuntao Yang, Fuhui Meng, Fenglian Que, Wenxia Xiao, Huying Rao, Yan Wan, Hugh S Taylor, Lingeng Lu
Hypotestosterone and erectile dysfunction (ED) occur frequently in males with type 2 diabetes. It is still clinically challenging to manage diabetes-induced ED. Here, we conducted a 2-arm randomized clinical study and in vitro cell line experiments to investigate the effects of nerve growth factor (NGF) on serum testosterone and ED in diabetic males with sensorimotor polyneuropathy and to identify its underlying mechanisms. The analyses of serum total testosterone (TT) and free testosterone (FT), and 5-item version of the International Index of Erectile Function (IIEF-5) score at baseline and after treatment show increases in TT (3...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29721586/corticosteroid-binding-globulin-induced-in-testicular-leydig-cells-by-perfluorooctanoic-acid-promotes-steroid-hormone-synthesis
#18
Sujie Sun, Jianshe Wang, Yin Lu, Jiayin Dai
Perfluorooctanoic acid (PFOA) is an abundant perfluoroalkyl substance widely applied in industrial and consumer products. It is a ubiquitous environmental pollutant and suspected endocrine disruptor. Corticosteroid-binding globulin (CBG) is a monomeric glycoprotein that can bind specifically to anti-inflammatory steroids, such as glucocorticoids and progesterone, in circulation. Our previous proteomic profile analysis revealed that CBG levels increased in testes after PFOA treatment. In the present study, we verified its increase in mouse testes following oral exposure to PFOA (0, 1...
May 2, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29721213/anabolic-androgenic-steroids-and-carcinogenicity-focusing-on-leydig-cell-a-literature-review
#19
REVIEW
Monica Salerno, Orazio Cascio, Giuseppe Bertozzi, Francesco Sessa, Antonietta Messina, Vincenzo Monda, Luigi Cipolloni, Antonio Biondi, Aurora Daniele, Cristoforo Pomara
Anabolic androgenic steroids (AAS) are some of the most common drugs used among athletes, frequently in combination with resistance training, to improve physical performance or for aesthetic purpose. A great number of scientific reports showed the detrimental effects of anabolic androgenic steroids on different organs and tissues. In this literature review, we analyzed the AAS-mediated carcinogenicity, focusing on Leydig cell tumor. AAS-induced carcinogenicity can affect DNA transcription through two pathways...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29713278/dehydroepiandrosterone-antagonizes-pain-stress-induced-suppression-of-testosterone-production-in-male-rats
#20
Qiqi Zhu, Fei Ge, Xiaoheng Li, Hou-Sheng Deng, Miao Xu, Tiao Bu, Jingyang Li, Yiyan Wang, Yuanyuan Shan, Ren-Shan Ge, Ming Yao
Background: Leydig cells secrete the steroid hormone, testosterone, which is essential for male fertility and reproductive health. Stress increases the secretion of glucocorticoid [corticosterone, (CORT) in rats] that decreases circulating testosterone levels in part through a direct action on its receptors in Leydig cells. Intratesticular CORT level is dependent on oxidative inactivation of CORT by 11β-hydroxysteroid dehydrogenase 1 (HSD11B1) in rat Leydig cells. Pain may cause the stress, thus affecting testosterone production in Leydig cells...
2018: Frontiers in Pharmacology
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