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https://www.readbyqxmd.com/read/29332128/pharmacologic-characterization-of-omidenepag-isopropyl-a-novel-selective-ep2-receptor-agonist-as-an-ocular-hypotensive-agent
#1
Tomoko Kirihara, Takazumi Taniguchi, Kenzo Yamamura, Ryo Iwamura, Kenji Yoneda, Noriko Odani-Kawabata, Atsushi Shimazaki, Takeshi Matsugi, Naveed Shams, Jin-Zhong Zhang
Purpose: The objective of this study was to investigate the pharmacologic characteristics of omidenepag isopropyl (OMDI), a compound developed as a novel intraocular pressure (IOP)-lowering agent, with better IOP control and fewer side effects than other prostanoid receptor agonists such as prostaglandin F receptor (FP) agonists. Methods: Binding activities of OMDI and its hydrolyzed form, omidenepag (OMD), to human recombinant prostanoid receptors (DP1-2, EP1-4, FP, and IP) were evaluated...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29331829/additional-small-dose-of-prostaglandin-f2%C3%AE-at-timed-artificial-insemination-failed-to-improve-pregnancy-risk-of-lactating-dairy-cows
#2
J A Sauls, B E Voelz, L G D Mendonça, J S Stevenson
Two experiments were performed to test the hypothesis that administering PGF2α concurrent with timed artificial insemination (AI) in lactating dairy cows would enhance pregnancy per AI (P/AI). In experiment 1, lactating Holstein cows (n = 289) in one herd were enrolled after a non-pregnancy diagnosis (30-36 d after AI) to synchronize subsequent ovulation before AI. Cows were assigned randomly to receive (im) 10 mg of PGF2α concurrent with timed AI (Day 0; treatment) or no injection (control). Blood samples were collected on Days -3, 0, and 13 to determine serum concentrations of progesterone...
January 3, 2018: Theriogenology
https://www.readbyqxmd.com/read/29329790/plant-derived-mpges-1-inhibitors-or-suppressors-a-new-emerging-trend-in-the-search-for-small-molecules-to-combat-inflammation
#3
REVIEW
Haroon Khan, Kannan R R Rengasamy, Aini Pervaiz, Seyed Mohammad Nabavi, Atanas G Atanasov, Mohammad A Kamal
Inflammation comprises the reaction of the body to injury, in which a series of changes of the terminal vascular bed, blood, and connective tissue tends to eliminate the injurious agent and to repair the damaged tissue. It is a complex process, which involves the release of diverse regulatory mediators. The current anti-inflammatory agents are challenged by multiple side effects and thus, new effective therapies are highly needed. The aim of this review is to summarize the described microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors or transcriptional suppressors from medicinal plants, which could be an ideal approach in the management of inflammatory disorders, but need further clinical trials in order to be ultimately validated...
December 23, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29329642/mesenchymal-stem-cell-macrophage-crosstalk-and-bone-healing
#4
Jukka Pajarinen, Tzuhua Lin, Emmanuel Gibon, Yusuke Kohno, Masahiro Maruyama, Karthik Nathan, Laura Lu, Zhenyu Yao, Stuart B Goodman
Recent research has brought about a clear understanding that successful fracture healing is based on carefully coordinated cross-talk between inflammatory and bone forming cells. In particular, the key role that macrophages play in the recruitment and regulation of the differentiation of mesenchymal stem cells (MSCs) during bone regeneration has been brought to focus. Indeed, animal studies have comprehensively demonstrated that fractures do not heal without the direct involvement of macrophages. Yet the exact mechanisms by which macrophages contribute to bone regeneration remain to be elucidated...
January 2, 2018: Biomaterials
https://www.readbyqxmd.com/read/29328471/prostaglandin-e2-receptor-ep4-is-involved-in-the-cell-growth-and-invasion-of-prostate-cancer-via-the-camp%C3%A2-pka-pi3k%C3%A2-akt-signaling-pathway
#5
Song Xu, Wenquan Zhou, Jingping Ge, Zhengyu Zhang
Prostate cancer (PCa) is one of the most prevalent diagnosed malignancies globally. Previous studies have demonstrated that prostaglandin E2 (PGE2) is closely associated with the tumorigenesis and progression of PCa. However, the underlying molecular mechanisms remain unclear and require further investigation. Matrix metalloproteinases (MMPs), receptor activator of nuclear factor‑κB ligand (RANKL) and runt‑related transcription factor 2 (RUNX2), which are involved in cell growth and bone metastasis, are frequently activated or overexpressed in various types of cancer, including PCa...
January 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29328467/aspirin-and-metformin-exhibit-antitumor-activity-in-murine-breast-cancer
#6
Maoyuan Zhao, Yuyi Wang, Chi Du, Yanyang Liu, Nan Zhang, Feng Luo
Studies have shown that aspirin and metformin play important roles in chemoprevention and repression of breast cancers, even though the exact mechanism remains unclear. Aspirin is capable of stimulating apoptosis through prostaglandin-dependent or prostaglandin-independent pathways. Metformin inhibits cell growth by enhancing the tumor suppressive function of transforming growth factor (TGF-β). In the present study, we report a new link between aspirin, metformin, TGF-β1 and murine breast cancer inhibition...
January 4, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29328440/methanol-extract-of-guettarda-speciosa-linn-inhibits-the-production-of-inflammatory-mediators-through-the-inactivation-of-syk-and-jnk-in-macrophages
#7
Hien Thi Thu Le, Young-Chang Cho, Sayeon Cho
Guettarda speciosa Linn. (G. speciosa, Rubiaceae) has been used as a traditional medicinal plant in Asia for the treatment of various inflammatory conditions, including cough, fever and maternal postpartum infection. However, the mechanisms underlying the anti‑inflammatory action of G. speciosa extracts have remained elusive. In the present study, the anti‑inflammatory effects of the methanol extract of G. speciosa (MGS) were investigated in murine macrophages by measuring the production of inflammatory mediators and the underlying mechanisms of action by performing immunoblotting analysis of proteins that are potentially involved...
January 10, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29328022/-endometriosis-a-new-approach-to-etiology-and-pathogenesis-review
#8
A Solopova, A Makacarya, E Chukanova
Endometriosis is a dyshormonal immune-dependent genetically determined disease, which appears as an endometrioid tissue that grows outside the uterine. Endometriosis is one of the most urgent problems of medicine. To date, new concepts of the endometriosis etiology and pathogenesis have been developed, but, despite their abundance, there is no unified theory. Genetic and epigenetic factors result in changes in an expression of aromatase, steroidogenic factor 1, and estrogen receptors are suggested to be the main cause of endometriosis...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29326169/dual-cyclooxygenase-fatty-acid-amide-hydrolase-inhibitor-exploits-novel-binding-interactions-in-the-cyclooxygenase-active-site
#9
Michael C Goodman, Shu Xu, Carol A Rouzer, Surajit Banerjee, Kebreab Ghebreselasie, Marco Migliore, Daniele Piomelli, Lawrence J Marnett
The cyclooxygenases COX-1 and COX-2 oxygenate arachidonic acid (AA) to prostaglandin H2 (PGH2). COX-2 also oxygenates the endocannabinoids, 2-arachidonoylglycerol (2-AG) and arachidonoylethanolamide (AEA), to the corresponding PGH2 analogs. Both enzymes are targets of nonsteroidal anti-inflammatory drugs (NSAIDs), but NSAID-mediated COX inhibition is associated with gastrointestinal toxicity. One potential strategy to counter this toxicity is to also inhibit fatty acid amide hydrolase (FAAH), which hydrolyzes bioactive fatty acid ethanolamides (FAEs) into fatty acids and ethanolamine...
January 11, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29326060/ovulation-is-associated-with-the-lh-dependent-induction-of-pla2g4aa-in-zebrafish
#10
Haipei Tang, Le Wang, Yu Chen, Jianan He, Ling Qu, Yin Guo, Yun Liu, Xiaochun Liu, Haoran Lin
The effects of the preovulatory luteinizing hormone (LH) surge on the ovulatory process are mediated by prostaglandins (PGs), the synthesis of which involves prostaglandin synthetase and cytosolic phospholipase A2 (cPLA2). In our previous study, we systematically investigated the function of prostaglandin endoperoxide synthase (ptgs) genes on ovulation in zebrafish. However, the role of cPLA2 in ovulation was not determined in zebrafish. In this study, we investigated the function of cpla2α in PGs production and ovulation in periovulatory follicles...
January 8, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29325908/corrigendum-to-rosuvastatin-inhibits-pressure-induced-fibrotic-responses-via-the-expression-regulation-of-prostacyclin-and-prostaglandin-e-2-in-rat-renal-tubular-cells-european-journal-of-pharmacology-700-2013-65-73
#11
Cheng-Hsien Chen, Chung-Yi Cheng, Yen-Cheng Chen, Yuh-Mou Sue, Yung-Ho Hsu, Wei-Lun Tsai, Tso-Hsiao Chen
No abstract text is available yet for this article.
January 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29324978/effect-of-fish-meal-supplementation-on-luteal-sensitivity-to-intrauterine-infusions-of-prostaglandin-f2alpha-in-the-bovine
#12
Michele R Plewes, Jessica C Cedillo, Patrick D Burns, Peter E Graham, Jason E Bruemmer, Terry E Engle
Progesterone is a steroid hormone secreted from the corpus luteum (CL), which is responsible for establishment and maintenance of pregnancy. Early embryonic mortality often occurs due to inadequate regulation of uterine prostaglandin (PG) F2alpha secretion, leading to decrease in progesterone and loss of pregnancy. The objective of the current study was to determine the effects of fish meal supplementation on luteal sensitivity to intrauterine infusions of PGF2alpha. Non-lactating beef cows received corn gluten meal or fish meal supplementation for 60-days...
January 9, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29324448/the-expression-of-hsd17b12-is-associated-with-cox-2-expression-and-is-increased-in-high-grade-epithelial-ovarian-cancer
#13
Heidi Kemiläinen, Kaisa Huhtinen, Annika Auranen, Olli Carpén, Leena Strauss, Matti Poutanen
OBJECTIVE: The aim of this study was to characterize the expression of hydroxysteroid (17β) dehydrogenase type 12 (HSD17B12), an enzyme involved in the synthesis of arachidonic acid (AA), in ovarian cancer, and to study its coexpression with its upstream and downstream enzymes in the AA pathway, namely elongation of very long chain fatty acids protein 5 (ELOVL5) and cyclooxygenase-2 (COX-2), respectively. MATERIALS AND METHODS: Samples from benign and malignant ovarian neoplastic lesions were immunohistochemically stained with HSD17B12, ELOVL5, and COX-2...
January 12, 2018: Oncology
https://www.readbyqxmd.com/read/29318710/evaluation-of-three-hormonal-protocols-for-anovulatory-lactating-cows-under-regulations-restricting-the-use-of-estrogenic-compounds
#14
Guang-Min Yu, Yue Wu, Xian-Long Wang, Shuan Zhao, Teruo Maeda, Shen-Ming Zeng
When European Union regulations restricted the use of estrogenic compounds in food-producing animals, refined hormonal protocols were no longer applicable for anovulatory cows. However, Ovsynch and its adaptations are routinely and uniformly applied to all cows regardless of ovarian function. To evaluate their efficacy on anovulatory cows, 143, 147 and 144 anovulatory cows received Ovsynch, Presynch and G6G protocols, respectively. In comparison, 150 cyclic cows were bred without using a synchronized protocol...
January 9, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29317280/post-diagnosis-aspirin-use-and-overall-survival-in-patients-with-melanoma
#15
Saleh Rachidi, Kristin Wallace, Hong Li, Tim Lautenschlaeger, Zihai Li
BACKGROUND: Mouse studies show that tumor-derived prostaglandins and platelets promote melanoma progression and immune-evasion. OBJECTIVE: Determine if aspirin confers longer survival in patients with melanoma. METHSODS: A retrospective cohort study of 1,522 patients at Indiana University Health (IUH) diagnosed with melanoma between 2000 and 2014 and followed up through September, 2016. RESULTS: Aspirin use was associated with longer overall survival in univariate analysis and after controlling for age, sex, stage, and treatment modalities (HR 0...
January 6, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29315797/high-luteinizing-hormone-weakens-urinary-continence-mechanisms-in-association-with-prostaglandin-e2-elevation-in-a-postmenopausal-rat-model
#16
Tomohiro Eriguchi, Naoki Kawamorita, Natsuho Hayashi, Yohei Satake, Hideaki Izumi, Yasuhiro Kaiho, Yoichi Arai
AIMS: To explore the role of luteinizing hormone (LH) in the urinary continence mechanism, urethral function was investigated using a postmenopausal rat model with high serum LH concentrations and the postmenopausal rat model given a gonadotropin releasing hormone (GnRH) antagonist to lower LH concentrations. METHODS: Adult female rats were divided into: 1) sham group; 2) ovariectomy group (OVX) with removal of bilateral ovaries; 3) OVX and GnRH-antagonist administered group (OVX + G); and 4) sham and GnRH-antagonist administered group (Sham + G)...
January 9, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29315006/the-role-of-iloprost-on-bone-oedema-and-osteonecrosis-review-of-current-evidence
#17
Ippokratis Pountos, Peter V Giannoudis
Iloprost is a commercially available prostaglandin I2 (PGI2) analogue that is shown to have antithrombotic, vasodilatative and antiproliferative effects. A number of clinical studies have shown that Iloprost can be effective in the management of bone marrow oedema and the treatment of avascular necrosis. The aim of this manuscript is to present our current understanding on the effect of Iloprost on the treatment of these conditions. Areas covered: The authors offer a comprehensive review of the existing literature on the experimental and clinical studies analysing the effect of Iloprost on bone, bone marrow oedema and avascular necrosis...
January 9, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29313164/treatment-of-nonocclusive-mesenteric-ischemia-with-type-b-aortic-dissection-using-intra-arterial-catheterization-after-trauma-surgery-case-report
#18
Sho Fujiwara, Yuki Sekine, Ryuichi Nishimura, Kazuya Tadasa, Shukichi Miyazaki
BACKGROUND: Nonocclusive mesenteric ischemia (NOMI) is a mesenteric arterial spasm and intestinal ischemia. This disease is a highly lethal disease because diagnosis and decision of appropriate treatments are often difficult. Operations cannot resolve the spasms and may worsen the situation. However, the safety and effectiveness of catheterization for NOMI with aortic dissection (AD) have not yet been elucidated. Here, we report a successful case of early diagnosis and treatment of NOMI with type B AD involving the superior mesenteric artery (SMA) using the intra-arterial infusion of a vasodilator via the SMA...
January 8, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29311680/inhibition-of-insulin-resistance-by-pge1-via-autophagy-dependent-fgf21-pathway-in-diabetic-nephropathy
#19
Wei Wei, Xing-Rong An, Shi-Jie Jin, Xiao-Xue Li, Ming Xu
Insulin resistance is a critical process in the initiation and progression of diabetic nephropathy (DN). Alprostadil (Prostaglandin E1, PGE1) had protective effects on renal function. However, it is unknown whether PGE1 inhibited insulin resistance in renal tubule epithelial cells via autophagy, which plays a protective role in DN against insulin resistance. Insulin resistance was induced by palmitic acid (PA) in human HK-2 cells, shown as the decrease of insulin-stimulated AKT phosphorylation, glucose transporter-4 (GLUT4), glucose uptake and enhanced phosphorylation of insulin receptor substrate 1(IRS-1) at site serine 307 (pIRS-1ser307) and downregulated expression of IRS-1...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311520/validation-of-a-novel-timed-artificial-insemination-protocol-in-beef-cows-with-a-functional-corpus-luteum-detected-by-ultrasonography
#20
Hisashi Funakura, Ayumi Shiki, Yuji Tsubakishita, Shogo Mido, Hiromu Katamoto, Go Kitahara, Takeshi Osawa
This study aimed to clarify the feasibility of a novel timed artificial insemination (TAI) protocol using ultrasonography, and to determine the associations between the ovarian component and fertility. In Experiment 1,272 Japanese Black cows with a corpus luteum (CL) ≥ 18 mm in diameter were divided randomly into either the TRT group (134 cows that were administered gonadotropin-releasing hormone [GnRH] 56 h [day 2] after prostaglandin F2α [PGF] administration [day 0], followed by TAI 16-20 h later) or the CN-1 group (138 cows that were administered PGF followed by AI after estrus detection)...
January 5, 2018: Journal of Reproduction and Development
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