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Prostaglandins

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https://www.readbyqxmd.com/read/28538979/stanniocalcin-1-is-an-ocular-hypotensive-agent-and-a-downstream-effector-molecule-that-is-necessary-for-the-intraocular-pressure-lowering-effects-of-latanoprost
#1
Gavin W Roddy, Kimberly B Viker, Nelson S Winkler, Cindy K Bahler, Bradley H Holman, David Sheikh-Hamad, Uttio Roy Chowdhury, W Daniel Stamer, Michael P Fautsch
Purpose: To identify downstream signaling molecules through which intraocular pressure (IOP) is lowered following treatment with the prostaglandin analog latanoprost. Methods: Total RNA and protein isolated from primary human Schlemm's canal cells (n = 3) treated with latanoprost (free acid; 100 nM) were processed for quantitative PCR and Western blot analysis. IOP was evaluated in stanniocalcin-1 (STC-1-/-) and wild-type mice following treatment with latanoprost or Rho kinase inhibitor Y27632...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28538876/combination-therapy-with-butyrate-and-docosahexaenoic-acid-for-keloid-fibrogenesis-an-in-vitro-study
#2
Kazuhiro Torii, Noriaki Maeshige, Michiko Aoyama-Ishikawa, Makoto Miyoshi, Hiroto Terashi, Makoto Usami
Background: A single, effective therapeutic regimen for keloids has not been established yet, and the development of novel therapeutic approaches is expected. Butyrate, a short-chain fatty acid, and docosahexaenoic acid (DHA), a ω-3 polyunsaturated fatty acid, play multiple anti-inflammatory and anticancer roles via their respective mechanisms of action. Objective: In this study, we evaluated the antifibrogenic effects of their single and combined use on keloid fibroblasts...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28533546/prostaglandin-e2-inhibits-matrix-mineralization-by-human-bone-marrow-stromal-cell-derived-osteoblasts-via-epac-dependent-camp-signaling
#3
Ali Mirsaidi, André N Tiaden, Peter J Richards
The osteoinductive properties of prostaglandin E2 (PGE2) and its signaling pathways have led to suggestions that it may serve as a potential therapeutic strategy for bone loss. However, the prominence of PGE2 as an inducer of bone formation is attributed primarily to findings from studies using rodent models. In the current study, we investigated the effects of PGE2 on human bone marrow stromal cell (hBMSC) lineage commitment and determined its mode of action. We demonstrated that PGE2 treatment of hBMSCs significantly altered the expression profile of several genes associated with osteoblast differentiation (RUNX2 and ALP) and maturation (BGLAP and MGP)...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28533326/prostaglandin-e-receptor-subtype-4-regulates-lipid-droplet-size-and-mitochondrial-activity-in-murine-subcutaneous-white-adipose-tissue
#4
Fan Ying, Yin Cai, Yu Cai, Yu Wang, Eva Hoi Ching Tang
The purpose of this study was to investigate whether genetic ablation of prostaglandin E receptor subtype 4 (EP4) affects white adipose tissue (WAT) remodeling mediated by β3-adrenergic stimulation. The selective β3-adrenergic agonist, CL316243 (1 mg/kg/d, i.p.) caused a greater increase in metabolic rate in EP4-knockout mice. CL316243 fragmented the unilocular lipid droplet into multilocular lipid vacuoles and increased mitochondrial biogenesis and its activity. These changes were amplified in mice with EP4 deficiency and were selectively seen in subcutaneous WAT...
May 22, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28532944/effect-of-prostaglandin-analogue-use-on-the-development-of-cystoid-macular-edema-after-phacoemulsification-using-strobe-statement-methodology
#5
REVIEW
David J Hernstadt, Rahat Husain
Cataract surgery is a common procedure, and cystoid macular edema (CME) is a sight-threatening complication. Prostaglandin analogues are the first-line therapy for glaucoma, but their effect on the risk for CME after phacoemulsification is unknown. A systematic search of Medline and PubMed was performed to determine the effect of the use of prostaglandin analogues (PGA) on the development of CME after cataract surgery. A total of 412 articles were identified. Thirteen articles met inclusion criteria and were analyzed using Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28532934/effects-of-topical-ketorolac-tromethamine-0-45-on-intraoperative-miosis-and-prostaglandin-e2-release-during-femtosecond-laser-assisted-cataract-surgery
#6
Jong Hwa Jun, Young-Sik Yoo, Sung A Lim, Choun-Ki Joo
PURPOSE: To determine the effects of topical 0.45% ketorolac tromethamine on intraoperative miosis and prostaglandin E2 (PGE2) release during femtosecond laser-assisted cataract surgery. SETTING: Seoul St. Mary's Hospital, Seoul, Korea. DESIGN: Prospective case series. METHODS: The study comprised the following 3 groups: conventional cataract surgery without topical NSAIDs (conventional group); femtosecond laser-assisted cataract surgery with preoperative topical ketorolac tromethamine 0...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28532844/effects-of-d-cloprostenol-on-different-layers-and-regions-of-the-bovine-uterus-during-the-follicular-and-luteal-phases
#7
M Piccinno, R L Sciorsci, V Masciopinto, M De Rosa, A Rizzo
INTRODUCTION: D-cloprostenol is a synthetic PGF2α, commonly used in bovine reproduction, that increases myometral contractility. However, little is known regarding its contractile behaviour and how it depends on the reproductive state and uterine topography (regions and muscular layers). HYPOTHESIS AND OBJECTIVES: These aspects would affect the action of d-cloprostenol on the uterus. Therefore, we hypothesize a possible use of this drug at the time of artificial insemination, to improve conception rates and, in the post-partum, in order to accelerate uterine involution in dairy cattle...
July 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28532683/the-essential-oil-from-the-twigs-of-cinnamomum-cassia-presl-inhibits-oxytocin-induced-uterine-contraction-in-vitro-and-in-vivo
#8
Lan Sun, Li-Na Liu, Jia-Chun Li, Yao-Zhong Lv, Shao-Bo Zong, Jun Zhou, Zheng-Zhong Wang, Jun-Ping Kou, Wei Xiao
ETHNOPHARMACOLOGICAL RELEVANCE: The twigs and bark of Cinnamomum cassia Presl (Lauraceae) are widely used in traditional Chinese medicine in the treatment of tumor, abdominal pain, dysmenorrhea, digestive system disease and inflammatory diseases. The aim of this study was to determine the inhibitory effect of the essential oil from the twigs of Cinnamomum cassia Presl (EOCC) on uterine contraction in vitro and in vivo. MATERIALS AND METHODS: The Institute of Cancer Research (ICR) mouse uterine contraction was induced by oxytocin (OT) exposure following estradiol benzoate pretreatment...
May 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28531997/sustained-release-of-growth-hormone-and-sodium-nitrite-from-biomimetic-collagen-coating-immobilized-on-silicone-tubes-improves-endothelialization
#9
Nasim Salehi-Nik, Zahra Malaie-Balasi, Ghassem Amoabediny, Seyedeh Parnian Banikarimi, Behrouz Zandieh-Doulabi, Jenneke Klein-Nulend
Biocompatibility of biomedical devices can be improved by endothelialization of blood-contacting parts mimicking the vascular endothelium's function. Improved endothelialization might be obtained by using biomimetic coatings that allow local sustained release of biologically active molecules, e.g. anti-thrombotic and growth-inducing agents, from nanoliposomes. We aimed to test whether incorporation of growth-inducing nanoliposomal growth hormone (nGH) and anti-thrombotic nanoliposomal sodium nitrite (nNitrite) into collagen coating of silicone tubes enhances endothelialization by stimulating endothelial cell proliferation and inhibiting platelet adhesion...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28529269/possible-role-of-ppar%C3%AE-in-the-negative-regulation-of-ovulatory-cascade-and-luteal-development-in-rats
#10
Ryohei Funahashi, Takanobu Sakamoto, Norihito Taguchi, Ryosuke Naiki, Ryota Terashima, Mitsumori Kawaminami, Shiro Kurusu
Peroxisome proliferator-activated receptor γ (PPARγ), a member of a nuclear receptor family, has been shown to be implicated in various reproductive processes. Here, we evaluated possible roles of PPARγ in ovulation and luteal development in a gonadotropins-primed immature rat model. Immunoreactive PPARγ was expressed in granulosa cells of eCG-stimulated mature follicles, and its expression level decreased following ovulatory hCG stimulus. Intra-bursal treatment with rosiglitazone (a PPARγ agonist) simultaneously with subcutaneously administered hCG blocked the induction of cyclooxygenase-2 and steroidogenic acute regulatory protein (StAR) in preovulatory follicles...
May 19, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28528506/exposure-of-marine-mussels-to-diclofenac-modulation-of-prostaglandin-biosynthesis
#11
Frédérique Courant, Lauren Arpin-Pont, Bénilde Bonnefille, Sébastien Vacher, Marina Picot-Groz, Elena Gomez, Hélène Fenet
Human pharmaceuticals, such as nonsteroidal anti-inflammatory drugs (NSAIDs), are an emerging threat to marine organisms. NSAIDs act through inhibition of cyclooxygenase (COX) conversion of arachidonic acid into prostaglandins. One experiment was carried out whereby marine mussels were exposed for 72 h to 1 and 100 μg/L diclofenac (DCF). A specific and sensitive method using liquid chromatography high-resolution tandem mass spectrometry was developed to quantify DCF in mussel tissues. The developed method could also clearly identify and quantify COX products, i...
May 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28527691/food-and-water-intake-body-temperature-and-metabolic-consequences-of-interleukin-1%C3%AE-microinjection-into-the-cingulate-cortex-of-the-rat
#12
B Csetényi, E Hormay, I Szabó, G Takács, B Nagy, K László, Z Karádi
In order to elucidate whether cytokine mechanisms of the cingulate cortex (cctx) are important in the central regulation of homeostasis, in the present study, feeding-metabolic effects of direct bilateral microinjection of interleukin-1β (IL-1β) into the cctx of the rat have been investigated. Short- (2h), medium (12h) and long-term (24h) food and water intakes and body temperature were measured after the intracerebral administration of this primary cytokine or vehicle solution, with or without paracetamol pretreatment...
May 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28526157/pharmacology-of-acetaminophen-nonsteroidal-antiinflammatory-drugs-and-steroid-medications-implications-for-anesthesia-or-unique-associated-risks
#13
REVIEW
Kenneth D Candido, Oscar J Perozo, Nebojsa Nick Knezevic
Acetaminophen, nonsteroidal antiinflammatory drugs (NSAIDs), and corticosteroids, historically used in perioperative management, are potent analgesic medications. They primarily inhibit the cyclooxygenase (COX) enzyme, decreasing the synthesis of prostaglandins, and modulating pain and temperature. Acetaminophen does not inhibit this synthesis at the inflammatory site. The primary mechanism of action of corticosteroids involves regulation of nuclear expression of genes involved in inflammatory pathways and other systemic effects...
June 2017: Anesthesiology Clinics
https://www.readbyqxmd.com/read/28526097/abundance-of-active-ingredients-in-sea-buckthorn-oil
#14
REVIEW
Aleksandra Zielińska, Izabela Nowak
Vegetable oils are obtained by mechanical extraction or cold pressing of various parts of plants, most often: seeds, fruits, and drupels. Chemically, these oils are compounds of the ester-linked glycerol and higher fatty acids with long aliphatic chain hydrocarbons (min. C14:0). Vegetable oils have a variety of properties, depending on their percentage of saturation. This article describes sea-buckthorn oil, which is extracted from the well characterized fruit and seeds of sea buckthorn. The plant has a large number of active ingredients the properties of which are successfully used in the cosmetic industry and in medicine...
May 19, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28525343/changes-of-hematological-and-biochemical-parameters-and-levels-of-pepsinogen-histamine-and-prostaglandins-in-dairy-cows-affected-with-left-displacement-of-the-abomasum
#15
O Al-Rawashdeh, Z Bani Ismail, A Talafha, A Al-Momani
The aims of this study were to determine the serum levels of pepsinogen, histamine, and prostaglandins F2α and E2 in lactating dairy cows affected with left displacement of the abomasum (LDA). In addition, the hematological and serum biochemical parameters were also determined in cows affected with LDA. A total of 52 adult lactating Holstein-Friesian cows affected with LDA and 30 normal cows (control) were used. In LDA cows, the average age, BCS and body weight were 4.9 ± 1.2 years, 2.5 ± 0.75, and 525 ± 150kg respectively...
March 28, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28524718/placental-protein-13-pp13-induced-vasodilation-of-resistance-arteries-from-pregnant-and-nonpregnant-rats-occurs-via-endothelial-signaling-pathways
#16
Tijana Drobnjak, Sveinbjörn Gizurarson, Natalia I Gokina, Hamutal Meiri, Maurizio Mandalá, Berthold Huppertz, George Osol
Placental protein 13 (PP13) induces hypotension in rats. This study aims to evaluate PP13 effects on isolated uterine arteries from nonpregnant and mid-pregnant rats. Vessels were isolated, cannulated, and pressurized to 50 mmHg within an arteriograph, preconstricted and exposed to increasing PP13 concentrations (10(-13)-10(-8) M). PP13 elicited 38-50% arterial vasodilation with half-maximum response (EC50) = 1 pM. The relaxation was mediated by activating the endothelial-signaling pathways of prostaglandin and nitric oxide (NO)...
May 19, 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/28524139/-ocular-hypotensive-effect-of-systemic-beta-blockers-in-patients-with-primary-glaucoma-and-arterial-hypertension
#17
A L Onishchenko, A V Kolbasko, A V Zakharova, E G Onishchenko, N M Zhilina
AIM: to evaluate the ocular hypotensive efficacy of systemic beta-blockers in primary glaucoma patients suffering from arterial hypertension (AH). MATERIAL AND METHODS: The study included 29 patients with POAG (58 eyes) aged from 47 to 83 years. Patients with stage I-III POAG received instillations of prostaglandin analogs and carbonic anhydrase inhibitors. All POAG patients also suffered from arterial hypertension and were prescribed selective beta-blockers (metoprolol, bisoprolol, or nebivalol) as monotherapy or as part of combination therapy (if the target arterial pressure had not been achieved under the initial treatment)...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28524136/-clinical-evaluation-of-the-effectiveness-of-cholinesterase-inhibition-with-neuromidin-in-the-treatment-of-primary-glaucoma-patients
#18
I A Zakharova, R V Avdeev, V A Pristavka, S N Surnin, V Yu Makhmutov, I I Savrasova
AIM: to investigate neuromidin effectiveness in the treatment of patients with primary glaucoma and compensated intraocular pressure (IOP). MATERIAL AND METHODS: A total of 40 patients (80 eyes) were examined. Of them, 10 eyes with early glaucoma, 36 eyes with moderate-stage glaucoma, 33 eyes with advanced glaucoma, and 1 eye with end-stage glaucoma. In 19 eyes, IOP was controlled through beta-blockers, in 11 eyes - through carbonic anhydrase inhibitors, in 10 eyes - through prostaglandin analogues, and in 39 eyes - through combination drugs...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28515743/acute-phase-proteins-and-oxidative-stress-in-patients-undergoing-coronary-artery-bypass-graft-comparison-of-cardioplegia-strategy
#19
Dariusz Plicner, Jarosław Stoliński, Anna Rzucidło-Hymczak, Bogusław Kapelak, Anetta Undas
INTRODUCTION: Several strategies are still being introduced to cardiac surgery techniques to reduce the signs of the inflammatory response and oxidative stress. Many efforts have been made to develop the best possible method for myocardial protection. AIM: To assess the effect of the cardioplegia strategy on the systemic inflammatory response and oxidative stress. MATERIAL AND METHODS: A group of 238 consecutive, elective on-pump coronary artery bypass graft patients (CABG; 183 men, aged 64...
March 2017: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28514385/-the-effects-of-diosmin-and-hesperidin-on-capillary-blood-flow-of-upper-limbs-in-patients-with-secondary-raynaud-s-syndrome
#20
A M Zudin, A G Gritsenko, I T Hadzhishvili
The article discusses the effects of diosmin and hesperidin on capillary blood flow in patients with secondary Raynaud's syndrome (RS). Raynaud's syndrome a difficult problem of modern angiology, since in its development there is a large range of disorders of the capillary blood flow of the limbs. Currently, the main way of therapy in patients with secondary Raynaud's syndrome is the use of either calcium channel blockers (if angiospastic stage of the disease), or prostaglandins of group E1 (with tropho-paralytic stage of secondary RS)...
2017: Khirurgiia
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