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computed Tomography systemic sclerosis

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https://www.readbyqxmd.com/read/27911673/genetic-syndromes-associated-with-central-nervous-system-tumors
#1
Charmi Vijapura, Ehab Saad Aldin, Aristides A Capizzano, Bruno Policeni, Yutaka Sato, Toshio Moritani
Several genetic tumor syndromes have associated central nervous system (CNS) neoplasms. The spectrum of syndromes that have intracranial tumor manifestations includes ataxia telangiectasia, Cowden syndrome, familial adenomatous polyposis, hereditary non-polyposis-related colorectal cancer, Li-Fraumeni syndrome, Gorlin syndrome, neurofibromatosis types 1 and 2, multiple endocrine neoplasia type 1, tuberous sclerosis complex, von Hippel-Lindau disease, and Turcot syndrome. Many of these disorders are inherited in an autosomal dominant fashion, and identification of the associated genetic defects has led to improved understanding of the molecular pathways involved in tumorigenesis, helping pave the way to the emergence of molecularly targeted therapeutics...
December 2, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27818558/is-computed-tomography-the-ideal-method-for-the-identification-and-management-of-lung-disease-in-systemic-sclerosis
#2
EDITORIAL
Agnaldo José Lopes
No abstract text is available yet for this article.
September 2016: Radiologia Brasileira
https://www.readbyqxmd.com/read/27818546/tomography-patterns-of-lung-disease-in-systemic-sclerosis
#3
REVIEW
Andréa de Lima Bastos, Ricardo de Amorim Corrêa, Gilda Aparecida Ferreira
Currently, lung impairment is the leading factor responsible for the morbidity and mortality associated with systemic sclerosis. Therefore, the recognition of the various tomography patterns becomes decisive in the clinical management of these patients. In high-resolution computed tomography studies, the most common pattern is that of nonspecific interstitial pneumonia. However, there are other forms of lung involvement that must also be recognized. The aim of this study was to review the literature on the main changes resulting from pulmonary involvement in systemic sclerosis and the corresponding radiological findings, considering the current classification of interstitial diseases...
September 2016: Radiologia Brasileira
https://www.readbyqxmd.com/read/27733938/serum-soluble-cd163-and-its-association-with-various-disease-parameters-in-patients-with-systemic-sclerosis
#4
Waleed Ahmed Salah Eldeen Hassan, Eman Abd Elaleem Baraka, Basant Mohammed Elnady, Tahany Mahmoud Gouda, Nehad Fouad
OBJECTIVE: Cluster of differentiation 163 (CD163) is a receptor that binds haptoglobin-hemoglobin complexes and is mainly expressed on macrophages and monocytes. As a result of shedding, the extracellular portion of CD163 circulates in the blood as a soluble CD163 (sCD163). This study aimed to measure serum sCD163 levels in patients with systemic sclerosis (SSc) and to assess its association with the clinical, laboratory, and radiological features of the disease. MATERIAL AND METHODS: We measured serum sCD163 levels in 24 patients with SSc and in 30 healthy controls...
September 2016: Eur J Rheumatol
https://www.readbyqxmd.com/read/27709074/correlation-of-delta-high-resolution-computed-tomography-hrct-score-with-delta-clinical-variables-in-early-systemic-sclerosis-ssc-patients
#5
Suparaporn Wangkaew, Juntima Euathrongchit, Pittaporn Wattanawittawas, Nuntana Kasitanon
BACKGROUND: The correlation of changes (delta: Δ) of high-resolution computed tomography (HRCT) score with the Δ of other clinical variables has not been well studied. The purpose of this study was to determine the correlation of Δ HRCT score with Δ percent predicted forced vital capacity (%pFVC), Δ modified Rodnan Skin Score (mRSS), Δ erythrocyte sedimentation rate (ESR), and Δ percent of oxygen saturation at room air (%SpO2) in patients with early systemic sclerosis (SSc). METHODS: We used an inception cohort of early-SSc patients seen at the Rheumatology Clinic, Chiang Mai University, Thailand, between January 2010 and June 2014...
August 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/27638998/fixing-the-jugular-flow-reduces-ventricle-volume-and-improves-brain-perfusion
#6
Paolo Zamboni, Erica Menegatti, Corrado Cittanti, Francesco Sisini, Sergio Gianesini, Fabrizio Salvi, Francesco Mascoli
OBJECTIVE: Increased ventricle volume and brain hypoperfusion are linked to neurodegeneration. We hypothesized that in patients with restricted jugular flow, surgical restoration may reduce brain ventricle volume, because it should improve the pressure gradient, hence promoting cerebrospinal fluid reabsorption into the venous system. METHODS: The effects of restoring the jugular flow were assessed by means of a validated echocardiography with color Doppler (ECD) protocol of flow quantification, magnetic resonance venography, and single-photon emission computed tomography combined with computed tomography (SPECT-CT)...
October 2016: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/27638345/pneumatosis-intestinalis-during-chemotherapy-with-nilotinib-in-a-patient-with-chronic-myeloid-leukemia-who-tested-positive-for-anti-topoisomerase-i-antibodies
#7
Akihito Fujimi, Hiroki Sakamoto, Yuji Kanisawa, Shinya Minami, Yasuhiro Nagamachi, Naofumi Yamauchi, Soushi Ibata, Junji Kato
A 55-year-old man with several comorbidities including idiopathic interstitial pneumonia under long-term corticosteroid therapy, longstanding myocardial infarction, chronic heart failure, paroxysmal atrial fibrillation, gastro-esophageal reflux disease, constipation, and history of paralytic ileus, was diagnosed with chronic myelogenous leukemia (CML) in the chronic phase. He also tested positive for anti-topoisomerase I antibodies without clinical diagnosis of any connective tissue disease, including systemic sclerosis...
December 2016: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/27635465/prevalence-and-risk-factors-for-left-ventricular-diastolic-dysfunction-in-a-scleroderma-cohort
#8
S Vemulapalli, L Cohen, V Hsu
OBJECTIVES: Left ventricular diastolic dysfunction (LVDD) is more common in systemic sclerosis (SSc) compared to the general population. Focal myocardial ischaemia and fibrosis may be important in its pathogenesis. LVDD is associated with increased mortality and little is known about the risk factors. Advanced SSc lung complications may accompany LVDD. METHOD: We conducted a cross-sectional study of 300 SSc outpatients with and without LVDD, seen between May 2012 and May 2014, and performed univariate and multivariate regression analyses to determine clinical factors associated with LVDD...
September 16, 2016: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/27586891/the-5-ht1a-receptor-agonist-buspirone-improves-esophageal-motor-function-and-symptoms-in-systemic-sclerosis-a-4-week-open-label-trial
#9
George P Karamanolis, Stylianos Panopoulos, Konstantinos Denaxas, Anastasios Karlaftis, Alexandra Zorbala, Dimitrios Kamberoglou, Spiros D Ladas, Petros P Sfikakis
BACKGROUND: Acute administration of the oral 5-HT1A receptor agonist buspirone, which is commonly used as an anxiolytic drug, may improve compromised lower esophageal sphincter function. In an open-label trial we assessed the effects of buspirone on esophageal motor function and symptoms in patients with esophageal involvement associated with systemic sclerosis (SSc). METHODS: Thirty consecutive patients with SSc and symptomatic esophageal involvement, despite treatment with proton pump inhibitors, underwent high resolution manometry and chest computed tomography for assessment of motor function and esophageal dilatation, respectively...
2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27564852/clinical-features-of-idiopathic-interstitial-pneumonia-with-systemic-sclerosis-related-autoantibody-in-comparison-with-interstitial-pneumonia-with-systemic-sclerosis
#10
Hideaki Yamakawa, Eri Hagiwara, Hideya Kitamura, Yumie Yamanaka, Satoshi Ikeda, Akimasa Sekine, Tomohisa Baba, Shinichiro Iso, Koji Okudela, Tae Iwasawa, Tamiko Takemura, Kazuyoshi Kuwano, Takashi Ogura
BACKGROUND: Patients with idiopathic interstitial pneumonias sometimes have a few features of connective tissue disease (CTD) and yet do not fulfil the diagnostic criteria for any specific CTD. OBJECTIVE: This study was conducted to elucidate the characteristics, prognosis, and disease behavior in patients with interstitial lung disease (ILD) associated with systemic sclerosis (SSc)-related autoantibodies. METHODS: We retrospectively analyzed medical records of 72 ILD patients: 40 patients with SSc (SSc-ILD) and 32 patients with SSc-related autoantibody-positive ILD but not with CTD (ScAb-ILD), indicating lung-dominant CTD with SSc-related autoantibody...
2016: PloS One
https://www.readbyqxmd.com/read/27518784/the-ivory-vertebra-sign
#11
Greg Matthews, Raymond B Dyer
The ivory verterba sign is indicative of diffuse sclerosis of a vertebral body. Though classically associated with osteoblastic metastatic disease, the appearance has also been described with multiple other conditions. Observable on Compute tomography or standard radiography, this sign can serve as a important clue to a systemic disease process.
August 12, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27497912/pulmonary-involvement-in-systemic-sclerosis
#12
Adriana Morales-Cárdenas, Camila Pérez-Madrid, Liliana Arias, Paulina Ojeda, María Paula Mahecha, Adriana Rojas-Villarraga, Jorge A Carrillo-Bayona, Juan-Manuel Anaya
Systemic sclerosis (SSc) is a multi-systemic autoimmune disease that mainly affects the skin, lungs, gastrointestinal tract, heart and kidneys. Pulmonary disease in patients with SSc is strongly associated with mortality. The mechanisms involved into its pathophysiology include the activation of autoimmune cells and hyperplasia of fibroblasts with an increased capacity to produce collagen and diminished collagen breakdown. Although pulmonary biopsy is the gold standard for the diagnosis of interstitial lung disease in SSc, the most commonly used method is high-resolution computed tomography due to its high sensitivity and specificity...
November 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27494629/safety-and-efficacy-of-extracorporeal-shock-wave-therapy-eswt-in-calcinosis-cutis-associated-with-systemic-sclerosis
#13
Sandra Blumhardt, Diana P Frey, Martin Toniolo, Hatem Alkadhi, Ulrike Held, Oliver Distler
OBJECTIVES: Calcinosis cutis is a frequent, difficult to treat manifestation of systemic sclerosis (SSc) associated with high morbidity. The aim of this prospective, controlled, monocentric study was to assess safety and efficacy of extracorporeal shock wave therapy (ESWT) for calcinosis cutis of the finger in SSc patients. METHODS: A 12-week proof of concept study in which 4 SSc patients with calcinosis cutis were treated at one painful finger with high-energy, focused ESWT, in 3 sessions with one-week interval between each session...
September 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27476623/serum-clara-cell-16-kda-protein-levels-and-lung-impairment-in-systemic-sclerosis-patients
#14
Anna Olewicz-Gawlik, Dorota Trzybulska, Barbara Kuznar-Kaminska, Katarzyna Katulska, Aleksandra Danczak-Pazdrowska, Halina Batura-Gabryel, Pawel Hrycaj
OBJECTIVE: To assess clinical utility of serum Clara cell 16-kDa protein measurements in relation with staging system for systemic sclerosis associated interstitial lung disease. MATERIALS AND METHODS: Serum levels of Clara cell 16-kDa protein were determined by ELISA in 28 systemic sclerosis patients and 30 healthy controls, and correlated with staging system for systemic sclerosis associated interstitial lung disease in systemic sclerosis patients. Lung involvement was assessed functionally (body plethysmography, diffusing capacity of the lung for carbon monoxide) and radiologically (an average disease extent on high resolution computed tomography of the lungs) in SSc patients...
July 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27465340/tuberous-sclerosis-complex-imaging-characteristics-in-11-cases-and-review-of-the-literature
#15
Shan Hu, Dao-Yu Hu, Wen-Zhen Zhu, Liang Wang, Zi Wang
Tuberous sclerosis complex (TSC) is an uncommon multiorgan disorder that may present many and different manifestations on imaging. Radiology plays an important role in diagnosis and management, and can substantially improve the clinical outcome of TSC. Therefore, a comprehensive understanding of this disease is essential for the radiologist. The manifestations of TSC on computer tomography (CT) and magnetic resonance (MR) images were analyzed. Eleven patients with a clinical diagnosis of TSC were retrospectively reviewed...
August 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27432675/infection
#16
Gaurav Saigal, Natalya Nagornaya, M Judith D Post
Imaging is useful in the diagnosis and management of infections of the central nervous system. Typically, imaging findings at the outset of the disease are subtle and nonspecific, but they often evolve to more definite imaging patterns in a few days, with less rapidity than for stroke but faster than for neoplastic lesions. This timing is similar to that of noninfectious inflammatory brain disease, such as multiple sclerosis. Fortunately, imaging patterns help to distinguish the two kinds of processes. Other than for sarcoidosis, the meninges are seldom involved in noninfectious inflammation; in contrast, many infectious processes involve the meninges, which then enhance with contrast on computed tomography (CT) or magnetic resonance imaging (MRI)...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27422431/imaging-features-of-medicine-related-osteonecrosis-of-the-jaws-comparison-between-panoramic-radiography-and-computed-tomography
#17
Yuxing Guo, Diancan Wang, Yang Wang, Xin Peng, Chuanbin Guo
OBJECTIVE: The current staging system of medicine-related osteonecrosis of the jaws (MRONJ) assigns patients to different stages based on clinical manifestations. The extent of bone disease cannot be fully determined without radiologic evaluation. Missing radiologic information may lead to incorrect classification of MRONJ, resulting in poor outcomes of treatment. The objective of this study was to compare computed tomography (CT) and panoramic radiography (PR) features of MRONJ in different stages to achieve accurate staging on the basis of combined findings from clinical staging and imaging...
August 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27399114/a-case-report-the-efficacy-of-pirfenidone-in-a-chinese-patient-with-progressive-systemic-sclerosis-associated-interstitial-lung-disease-a-care-compliant-article
#18
Hui Huang, Rui E Feng, Shan Li, Kai Xu, Ya Lan Bi, Zuo Jun Xu
Systemic sclerosis (SSc)-associated interstitial lung disease (SSc-ILD) has become the leading SSc-related cause of death. Although various types of immunosuppressive therapy have been attempted for patients with SSc-ILD, no curative or effective treatment strategies for SSc-ILD have been developed. Therefore, management of patients with SSc-ILD remains a challenge. Here, we report a Chinese, female, SSc-ILD patient who was negative for Scl-70 and showed an excellent response to pirfenidone without obvious adverse effects...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27387267/interstitial-lung-disease-in-systemic-sclerosis-progress-in-screening-and-early-diagnosis
#19
Øyvind Molberg, Anna-Maria Hoffmann-Vold
PURPOSE OF REVIEW: Interstitial lung disease (ILD) is the major determinant of morbidity and mortality in systemic sclerosis (SSc). In highly selected SSc patients, it was recently shown that stem cell therapy early in the disease course improved survival and reduced the extent of ILD, providing a rationale for early ILD detection strategies in this disease. Here, we review recent progress on ILD screening and early diagnosis in SSc. RECENT FINDINGS: Two studies showed that over 60% of unselected SSc cases with ILD by high-resolution computer tomography (HRCT) had normal range pulmonary function tests (PFTs); indicating poor performance of PFTs for ILD screening purposes...
November 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27377409/mir-155-in-the-progression-of-lung-fibrosis-in-systemic-sclerosis
#20
Romy B Christmann, Alicia Wooten, Percival Sampaio-Barros, Claudia L Borges, Carlos R R Carvalho, Ronaldo A Kairalla, Carol Feghali-Bostwick, Jessica Ziemek, Yu Mei, Salma Goummih, Jiangning Tan, Diana Alvarez, Daniel J Kass, Mauricio Rojas, Thiago Lemos de Mattos, Edwin Parra, Giuseppina Stifano, Vera L Capelozzi, Robert W Simms, Robert Lafyatis
BACKGROUND: MicroRNA (miRNA) control key elements of mRNA stability and likely contribute to the dysregulated lung gene expression observed in systemic sclerosis associated interstitial lung disease (SSc-ILD). We analyzed the miRNA gene expression of tissue and cells from patients with SSc-ILD. A chronic lung fibrotic murine model was used. METHODS: RNA was isolated from lung tissue of 12 patients with SSc-ILD and 5 controls. High-resolution computed tomography (HRCT) was performed at baseline and 2-3 years after treatment...
July 5, 2016: Arthritis Research & Therapy
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