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https://www.readbyqxmd.com/read/28531109/physical-activity-and-quality-of-life-in-cancer-survivors-a-meta-synthesis-of-qualitative-research
#1
REVIEW
Shaunna Burke, Amanda Wurz, Andrew Bradshaw, Stephanie Saunders, Malcolm A West, Jennifer Brunet
Qualitative research on the impact of physical activity on quality of life (QoL) in adults diagnosed with cancer is accumulating. However, the field of physical activity and cancer survivorship lack a synthesis of this research to reliably understand the implications for future research and practice. The aim of this meta-synthesis was to identify, appraise, and synthesize qualitative research on cancer survivors' perspectives of the impact of physical activity on their QoL. Seven electronic databases were searched for original studies published in English, and reference lists of relevant studies were hand-searched to identify additional studies...
May 20, 2017: Cancers
https://www.readbyqxmd.com/read/28530543/using-properties-of-tumor-microenvironments-for-controlling-local-on-demand-delivery-from-biopolymer-based-nanocarriers
#2
Abdullah K Alshememry, Suleiman S El-Tokhy, Larry D Unsworth
BACKGROUND: The 'tumor microenvironment' comprised of tumor cells, non-malignant stromal tissues, signaling molecules and the extracellular matrix. Tumor microenvironment has unique physical and physiological characteristics including vascular abnormalities, hypoxia, acidic pH, specific enzymes and growth factors upregulation and high reducing potential. It is these endogenous properties of the tumor environment that can be used to trigger the release of cancer therapeutics both locally and as a function of disease state...
May 21, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28530194/solvent-effect-in-the-synthesis-of-hydrophobic-drug-loaded-polymer-nanoparticles
#3
Sandip Pal, Chabita Saha
Quercetin is an abundant flavonoid in fruits, vegetables such as onion, tea leaves, cranberry, radish leaves etc. with numerous biological activities and widely used as an effective antioxidant. Its low solubility in water and chemical decomposition in intestinal environment are predicaments in delivery through dietary or oral intake. Noble polymeric nanoparticles are of particular interest today because of their applications in many areas. Polymer nanoparticles have attracted the interest of many research groups and have been utilised in an increasing number of fields such as site targeted drug delivery in cancer research during the last decades...
June 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28528727/sexual-inactivity-in-partnered-female-cancer-survivors
#4
Jennifer L Marino, Christobel M Saunders, Martha Hickey
OBJECTIVE: To measure sexual activity in a clinic population of partnered female cancer survivors, and to better understand reasons for sexual inactivity in this population. MATERIALS AND METHODS: Partnered peri- or post-menopausal cancer survivors seen at a specialty clinic for menopause symptoms after cancer completed Fallowfield's Sexual Activity Questionnaire, quality of life measures (the Functional Assessment of Cancer Therapy General, Breast Cancer, and Endocrine Symptom Scales), and the Greene Climacteric Scale...
May 9, 2017: Maturitas
https://www.readbyqxmd.com/read/28528692/insulin-like-growth-factor-igf-axis-in-cancerogenesis
#5
REVIEW
Aldona Kasprzak, Wojciech Kwasniewski, Agnieszka Adamek, Anna Gozdzicka-Jozefiak
Determination of the role of insulin-like growth factor (IGF) family components in carcinogenesis of several human tumors is based on numerous epidemiological and pre-clinical studies, experiments in vivo and in vitro and on attempts at application of drugs affecting the IGF axis. Investigative hypotheses in original studies were based on biological functions manifested by the entire family of IGF (ligands, receptors, linking proteins, adaptor molecules). In the context of carcinogenesis the most important functions of IGF family involve intensification of proliferation and inhibition of cell apoptosis and effect on cell transformation through synthesis of several regulatory proteins...
April 2017: Mutation Research
https://www.readbyqxmd.com/read/28528421/end-of-life-care-for-glioblastoma-patients-at-a-large-academic-cancer-center
#6
Kamini E Kuchinad, Roy Strowd, Anne Evans, W Anthony Riley, Thomas J Smith
Glioblastoma (GBM) is a universally fatal disease, complicated by significant cognitive and physical disabilities, inherent to the disease course. The purpose of this study was to retrospectively analyze end-of-life care for GBM patients at an academic center and compare utilization of these services to national quality of care guidelines, with the goal of identifying opportunities to improve end-of-life care. Single center retrospective cohort study of GBM patients at Johns Hopkins Hospital (JHH) between 2009 and 2014, using electronic medical records and hospice records...
May 20, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28528291/the-association-of-lifetime-physical-inactivity-with-bladder-and-renal-cancer-risk-a-hospital-based-case-control-analysis
#7
Rikki Cannioto, John Lewis Etter, Lauren Beryl Guterman, Janine M Joseph, Nicholas R Gulati, Kristina L Schmitt, Michael J LaMonte, Ryan Nagy, Albina Minlikeeva, James Brian Szender, Kirsten B Moysich
OBJECTIVES: Recreational physical inactivity has been gaining recognition as an independent epidemiological exposure of interest in relation to cancer endpoints due to evidence suggesting that it may associate with cancer independent of obesity. In the current analyses, we examined the associations of lifetime recreational physical inactivity with renal and bladder cancer risk. METHODS: In this hospital-based case-control study, we identified N=160 renal cancer patients, N=208 bladder cancer patients, and N=766 age frequency-matched controls without cancer...
May 18, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28527672/quality-of-life-among-long-term-survivors-of-advanced-stage-ovarian-cancer-a-cross-sectional-approach
#8
Susan K Lutgendorf, Eileen Shinn, Jeanne Carter, Susan Leighton, Keith Baggerly, Michele Guindani, Bryan Fellman, Marianne Matzo, George M Slavich, Marc T Goodman, William Tew, Jenny Lester, Kathleen M Moore, Beth Y Karlan, Douglas A Levine, Anil K Sood
PURPOSE: Long-term survival of women with advanced-stage ovarian cancer is relatively rare. Little is known about quality of life (QOL) and survivorship concerns of these women. Here, we describe QOL of women with advanced-stage ovarian cancer surviving for 8.5 years or longer and compare women with 0-1 recurrence to those with multiple recurrences. METHODS: Participants (n=56) recruited from 5 academic medical centers and the Ovarian Cancer Research Fund Alliance completed surveys regarding QOL (FACT-O), mood (CESD), social support (SPS), physical activity (IPAQ-SF), diet, and clinical characteristics...
May 17, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28527621/physical-activity-patterns-and-associations-with-health-related-quality-of-life-in-bladder-cancer-survivors
#9
Ajay Gopalakrishna, Thomas A Longo, Joseph J Fantony, Michael R Harrison, Brant A Inman
INTRODUCTION: Physical activity has been shown to significantly improve health-related quality of life (HRQOL) and survivorship in a variety of patients with cancer . However, little is known about the physical activity patterns of bladder cancer survivors and how these are related to HRQOL in the United States. Our objective was to describe self-reported physical activity patterns and HRQOL and examine the association between these measures in a large cohort of bladder cancer survivors...
May 17, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28527256/-stat3-activation-by-hypoxia-in-in-vitro-models-of-cervix-cancer-and-endothelial-cells
#10
Óscar Ortega, Alejandro Ondo-Méndez, Ruth Garzón
INTRODUCTION: The biological behavior of cancer cells is influenced by the tumor microenvironment in which they develop. In this context, stressor stimuli such as hypoxia are considered critical for tumor development and therapeutic management. Cellular response to various stimuli is evidenced in the activation of intracellular signaling pathways such as JAK/STAT, which is one of the most important for its effects in differentiation and cell proliferation. OBJECTIVE: To evaluate the condition of the JAK/STAT pathway through the expression/activation of the STAT3 protein in cervix cancer cells (HeLa) and endothelial cells (EA...
January 24, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28526365/calibration-and-validation-of-the-youth-activity-profile-the-flashe-study
#11
Pedro F Saint-Maurice, Youngwon Kim, Paul Hibbing, April Y Oh, Frank M Perna, Gregory J Welk
INTRODUCTION: This study describes the calibration and validity of the Youth Activity Profile (YAP) for use in the National Cancer Institute's Family Life, Activity, Sun, Health, and Eating (FLASHE) study. The calibrated YAP was designed to estimate minutes of moderate to vigorous physical activity (MVPA) and sedentary behavior (SB). METHODS: The YAP was calibrated/validated in adolescents (aged 12-17 years) using cross-sectional data from the FLASHE study. Participants wore a GT3X+ ActiGraph on the dominant wrist for 7 days and then completed the YAP...
June 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28526364/surveillance-of-youth-physical-activity-and-sedentary-behavior-with-wrist-accelerometry
#12
Youngwon Kim, Paul Hibbing, Pedro F Saint-Maurice, Laura D Ellingson, Erin Hennessy, Dana L Wolff-Hughes, Frank M Perna, Gregory J Welk
INTRODUCTION: Accurate tracking of physical activity (PA) and sedentary behavior (SB) is important to advance public health, but little is known about how to interpret wrist-worn accelerometer data. This study compares youth estimates of SB and moderate to vigorous PA (MVPA) obtained using raw and count-based processing methods. METHODS: Data were collected between April and October 2014 for the National Cancer Institute's Family Life, Activity, Sun, Health, and Eating Study: a cross-sectional Internet-based study of youth/family cancer prevention behaviors...
June 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28526361/recruitment-enrollment-and-response-of-parent-adolescent-dyads-in-the-flashe-study
#13
April Y Oh, Terisa Davis, Laura A Dwyer, Erin Hennessy, Tiandong Li, Amy L Yaroch, Linda C Nebeling
INTRODUCTION: In 2014, the National Cancer Institute conducted the Family Life, Activity, Sun, Health, and Eating Study (FLASHE). This parent and adolescent survey examines psychosocial; generational (parent-adolescent); and environmental (home and neighborhood) correlates of cancer-preventive behaviors, with a particular emphasis on diet and physical activity. This paper describes the FLASHE data collection methods and enrollment and response rates. METHODS: FLASHE data collection methods included web-based surveys delivered to dyads of parents and their adolescent children, and deployment of accelerometers to a subset of adolescents, to achieve study goals in a nationwide study sample...
June 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28526360/the-flashe-study-survey-development-dyadic-perspectives-and-participant-characteristics
#14
Linda C Nebeling, Erin Hennessy, April Y Oh, Laura A Dwyer, Heather Patrick, Heidi M Blanck, Frank M Perna, Rebecca A Ferrer, Amy L Yaroch
The National Cancer Institute developed the Family Life, Activity, Sun, Health, and Eating (FLASHE) Study to examine multiple cancer preventive behaviors within parent-adolescent dyads. The purpose of creating FLASHE was to enable the examination of physical activity, diet, and other cancer preventive behaviors and potential correlates among parent-adolescent dyads. FLASHE surveys were developed from a process involving literature reviews, scientific input from experts in the field, cognitive testing, and usability testing...
June 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28526031/breast-cancer-relatives-physical-activity-intervention-needs-and-preferences-qualitative-results
#15
Sheri J Hartman, Rochelle K Rosen
BACKGROUND: While many risk factors for breast cancer, such as family history, are not modifiable, some, however, can be modified. The study used formative qualitative research to learn about the physical activity intervention preferences and needs of first-degree female relatives (FDFRs) of breast cancer patients; that information was then used to develop a targeted physical activity intervention. METHODS: Twenty FDFRs first completed a 12-week physical activity intervention and then attended two sequential focus groups (7 groups total)...
May 19, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28525464/the-cardiac-rehabilitation-model-improves-fitness-quality-of-life-and-depression-in-breast-cancer-survivors
#16
Lianne B Dolan, Danielle Barry, Teresa Petrella, Lindsay Davey, Ann Minnes, Allison Yantzi, Susan Marzolini, Paul Oh
PURPOSE: Exercise is a demonstrated, therapeutic strategy for cancer survivors to minimize many treatment-induced side effects and may decrease risk of recurrence. Nonetheless, structured programs that combine exercise and education are not yet standardized within cancer care. The Health, Exercise, Active Living, Therapeutic lifestyle (HEALTh) program is a clinical exercise program based on the established cardiac rehabilitation model, but customized for female breast cancer survivors...
May 18, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28523941/lifestyle-as-medicine-the-case-for-a-true-health-initiative
#17
David L Katz, Elizabeth P Frates, Jonathan P Bonnet, Sanjay K Gupta, Erkki Vartiainen, Richard H Carmona
The power of lifestyle as medicine was perceived thousands of years ago. There is now consistent and compelling science to support the important influence of lifestyle on health. Approximately 80% of chronic disease and premature death could be prevented by not smoking, being physically active, and adhering to a healthful dietary pattern. Cardiovascular disease, diabetes, stroke, dementia, and cancer are all influenced by lifestyle choices. Despite the ample evidence about what behaviors promote health, confusion still prevails among the general population...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28523723/patient-characteristics-and-surgery-related-factors-associated-with-patient-reported-recovery-at-1-and-6%C3%A2-months-after-colorectal-cancer-surgery
#18
J Jakobsson, E Idvall, C Kumlien
Predictors for postoperative recovery after colorectal cancer surgery are usually investigated in relation to length of stay (LoS), readmission, or 30-day morbidity. This study describes patient characteristics and surgery-related factors associated with patient-reported recovery 1 and 6 months after surgery. In total, 153 consecutively included patients who were recovering from colorectal cancer surgery reported their level of recovery using the Postoperative Recovery Profile. Multiple logistic regression analysis was used to calculate associations with recovery, defined as good or poor, divided into five recovery dimensions: physical symptoms, physical functions, psychological, social and activity...
May 19, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28522599/engineering-macrophages-to-eat-cancer-from-marker-of-self-cd47-and-phagocytosis-to-differentiation
#19
REVIEW
Cory Alvey, Dennis E Discher
The ability of a macrophage to engulf and break down invading cells and other targets provides a first line of immune defense in nearly all tissues. This defining ability to "phagos" or devour can subsequently activate the entire immune system against foreign and diseased cells, and progress is now being made on a decades-old idea of directing macrophages to phagocytose specific targets, such as cancer cells. Engineered T cells provide precedence with recent clinical successes against liquid tumors, but solid tumors remain a challenge, and a handful of clinical trials seek to exploit the abundance of tumor-associated macrophages instead...
May 18, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28521815/proportion-of-cancer-in-a-middle-eastern-country-attributable-to-established-risk-factors
#20
Maya A Charafeddine, Sara H Olson, Deborah Mukherji, Sally N Temraz, Ghassan K Abou-Alfa, Ali I Shamseddine
BACKGROUND: Providing an estimate of the percentage of cancer in Lebanon by 2018 that is due to the exposure to risk factors in 2008. Factors include: smoking, body mass index (BMI), physical inactivity, dietary factors, alcohol consumption, infections, and air pollution in adults. METHOD: Population Attributable Fraction (PAF) was calculated using the proportion of the population exposed and relative risks for each risk factor from meta-analyses. The PAF estimates the proportion of cases in which exposure may have played a causal role...
May 18, 2017: BMC Cancer
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