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https://www.readbyqxmd.com/read/29235567/alcohol-and-oestrogen-metabolites-in-postmenopausal-women-in-the-women-s-health-initiative-observational-study
#1
Mary C Playdon, Sally B Coburn, Steven C Moore, Louise A Brinton, Nicolas Wentzensen, Garnet Anderson, Robert Wallace, Roni T Falk, Ruth Pfeiffer, Xia Xu, Britton Trabert
BACKGROUND: Alcohol consumption is associated with an increased risk of several cancers. Potential mechanisms include altered oestrogen metabolism. Parent oestrogens metabolise into alternate pathways of oestrogen metabolites that may have variable effects on cancer pathogenesis. We examined associations of alcohol consumption with circulating oestrogen/oestrogen metabolites in postmenopausal women in the Women's Health Initiative (WHI)-Observational Study (OS). METHODS: We conducted a cross-sectional analysis of prediagnosis ovarian/endometrial cancer case-control data within WHI-OS (N=1864)...
December 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29235293/-chemical-constituents-from-petroleum-ether-fraction-of-swertia-chirayita-and-their-activities-in-vitro
#2
Rong-Rong You, Xue-Qing Chen, Dan-Dan He, Chang-Gao Huang, Yang Jin, Shi-Hui Qian, Jian-Ming Ju, Jun-Ting Fan
The present work is to study the chemical constituents from petroleum ether fraction of Tibetan medicine Swertia chirayita by column chromatography and recrystallization. The structures were identified by physical and chemical properties and spectral data as swerchirin (1), decussatin (2), 1,8-dihydroxy-3,5,7-trimethoxyxanthone (3), 1-hydroxy-3,5,7,8-tetramethoxyxanthone (4), bellidifolin (5), 1-hydroxy-3, 7-dimethoxyxanthone (6), methylswertianin (7), 1-hydroxy-3,5-dimethoxyxanthone (8), erythrodiol (9), oleanolic acid (10), gnetiolactone (11), scopoletin (12), sinapaldehyde (13), syringaldehyde (14), and β-sitosterol (15)...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29234262/physical-activity-decreases-kidney-cancer-mortality
#3
Michael Liss, Loki Natarajan, Aws Hasan, Jonathan L Noguchi, Martha White, J Kellogg Parsons
Background: To investigate associations of kidney cancer mortality with modifiable risk factors of obesity, physical activity, and smoking. Methods: We evaluate baseline data from US National Health Information Survey from 1998 through 2004 linked to mortality data reporting deaths through 2006. The primary outcome variable was kidney cancer-specific mortality and primary exposure variables were self-reported physical activity and body mass index (BMI). We utilized multivariable adjusted Cox proportional hazards regression models, with delayed entry to account for age at survey interview...
November 2017: Current Urology
https://www.readbyqxmd.com/read/29231755/pharmaceutical-aspects-of-silver-nanoparticles
#4
Prateek Mathur, Swati Jha, Suman Ramteke, N K Jain
Silver nanoparticles are particles in the size ranging between 1 and 100 nm. The two major methods used for synthesis of silver nanoparticle are the physical and chemical methods with the disadvantage that they are expensive and can also have toxicity. Biological method is being used as an expedient alternative, as this approach is environment-friendly and less toxic and it includes plant extracts, microorganism, fungi, etc. The major applications of silver nanoparticles in the medical field include diagnostic applications and therapeutic applications, apart from its antimicrobial activity...
December 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29231044/a-systematic-review-of-exercise-and-psychosocial-rehabilitation-interventions-to-improve-health-related-outcomes-in-patients-with-bladder-cancer-undergoing-radical-cystectomy
#5
Elke Rammant, Karel Decaestecker, Renée Bultijnck, Nora Sundahl, Piet Ost, Nele S Pauwels, Benedicte Deforche, Ronny Pieters, Valérie Fonteyne
OBJECTIVE: Summarizing the evidence on the effects of pre- and postoperative exercise and psychosocial rehabilitation interventions on patient-reported outcomes (PROs) and physical fitness in bladder cancer patients undergoing radical cystectomy. DATA SOURCES: The Cochrane Central Register of Controlled Trials, MEDLINE, Embase, Web of Science and the Physiotherapy Evidence Database were searched independently by two authors from inception until 10 November 2017...
December 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29229759/jmjd6-induces-hotair-an-oncogenic-lincrna-by-physically-interacting-with-its-proximal-promoter
#6
Antara Biswas, Abhijith Shettar, Geetashree Mukherjee, Paturu Kondaiah, Kartiki V Desai
<span style="color: black;">Using microarray analysis we found that HOX transcript antisense intergenic RNA (HOTAIR) is upregulated by Jumonji domain containing-6 (JMJD6), a bifunctional lysyl hydroxylase and arginine demethylase. In breast cancer, JMJD6 and HOTAIR RNAs increase tumor growth and associate with poor prognosis but no molecular relationship between them is known. We show that overexpression of JMJD6 increased HOTAIR expression and JMJD6 siRNAs suppressed it in ER+ MCF-7, triple negative MDA-MB-231 and non-breast cancer HEK 293 cells...
December 11, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29228614/dual-effects-of-radiation-bystander-signaling-in-urothelial-cancer-purinergic-activation-of-apoptosis-attenuates-survival-of-urothelial-cancer-and-normal-urothelial-cells
#7
Malgorzata A Bill, Kirtiman Srivastava, Conor Breen, Karl T Butterworth, Stephen J McMahon, Kevin M Prise, Karen D McCloskey
Radiation therapy (RT) delivers tumour kill, directly and often via bystander mechanisms. Bladder toxicity is a dose limiting constraint in pelvic RT, manifested as radiation cystitis and urinary symptoms. We aimed to investigate the impact of radiation-induced bystander signaling on normal/cancer urothelial cells. Human urothelial cancer cells T24, HT1376 and normal urothelial cells HUC, SV-HUC were used. Cells were irradiated and studied directly, or conditioned medium from irradiated cells (CM) was transferred to naïve, cells...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228091/a-randomized-phase-ii-study-evaluating-different-maintenance-schedules-of-nab-paclitaxel-in-the-first-line-treatment-of-metastatic-breast-cancer-final-results-of-the-ibcsg-42-12-big-2-12-snap-trial
#8
A Gennari, Z Sun, U Hasler-Strub, M Colleoni, M J Kennedy, R Von Moos, J Cortés, M J Vidal, B Hennessy, J Walshe, K Amillano Parraga, K Ribi, J Bernhard, S Murillo Morales, O Pagani, A Barbeaux, S Borstnar, M Rabaglio-Poretti, R Maibach, M M Regan, G Jerusalem
Background: The phase II SNAP trial was designed to evaluate the efficacy of alternative chemotherapy schedules for prolonged administration in HER2-negative metastatic breast cancer (MBC), after a short induction at conventional doses. Methods: Between April 2013 and August 2015, 258 women untreated with chemotherapy for MBC were randomly assigned to receive three different maintenance chemotherapy schedules after three cycles of identical induction chemotherapy: Arm A, nab-Paclitaxel 150 mg/m2 days 1,15 Q28; Arm B, nab-Paclitaxel 100 mg/m2 days 1,8,15 Q28; Arm C, nab-Paclitaxel 75 mg/m2 days 1,8,15,22 Q28...
December 8, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29227545/overexpression-of-sirt6-is-a-novel-biomarker-of-malignant-human-colon-carcinoma
#9
Chang-Hui Geng, Chun-Ling Zhang, Jing-Yan Zhang, Ping Gao, Miao He, Yan-Lin Li
Sirt family has been reported playing a significant role in the cancer develop, special its deacetylase activity plays a key function, but whether SIRT6 plays a role in mediating tumor EMT and metastasis in colon cancer has not been explored. Here, the mass spectrometry and co-immunoprecipitation assays were utilized to detect that SIRT6 was physically associated with transcription factor snail. Most important, HCT116 cells transfected with SIRT6 shRNA reversed EMT, while increased the expression of TET1, and the HCT116 cells transfected with SIRT6 displayed the contrary tendency...
December 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29226994/demographic-and-clinical-correlates-of-accelerometer-assessed-physical-activity-and-sedentary-time-in-lung-cancer-survivors
#10
Adrijana D'Silva, Gwyn D Bebb, Terry Boyle, Steven T Johnson, Jeff K Vallance
OBJECTIVE: To determine demographic and clinical correlates of accelerometer assessed physical activity and sedentary time among a population-based sample of lung cancer survivors. METHODS: Lung cancer survivors in Southern Alberta, Canada (N=527) were invited to complete a mailed survey assessing socio-demographics and wear an Actigraph® GT3X+ accelerometer for seven days. Average daily minutes of physical activity and sedentary time were derived from the accelerometer data...
December 11, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29225941/beyond-menstrual-hygiene-addressing-vaginal-bleeding-throughout-the-life-course-in-low-and-middle-income-countries
#11
REVIEW
Marni Sommer, Penelope A Phillips-Howard, Therese Mahon, Sasha Zients, Meredith Jones, Bethany A Caruso
Girls and women experience numerous types of vaginal bleeding. These include healthy reproductive processes, such as menstruation and bleeding after childbirth, but also bleeding related to health conditions, such as fibroids or cancer. In most societies, the management of menstruation is handled covertly, something girls are often instructed about at menarche. The management of other vaginal bleeding is often similarly discreet, although behaviours are not well documented. In many societies, cultural taboos frequently hinder open discussion around vaginal bleeding, restricting information and early access to healthcare...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29224095/sex-differences-in-muscle-wasting
#12
Lindsey J Anderson, Haiming Liu, Jose M Garcia
With aging and other muscle wasting diseases, men and women undergo similar pathological changes in skeletal muscle: increased inflammation, enhanced oxidative stress, mitochondrial dysfunction, satellite cell senescence, elevated apoptosis and proteasome activity, and suppressed protein synthesis and myocyte regeneration. Decreased food intake and physical activity also indirectly contribute to muscle wasting. Sex hormones also play important roles in maintaining skeletal muscle homeostasis. Testosterone is a potent anabolic factor promoting muscle protein synthesis and muscular regeneration...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29223719/physical-activity-and-weight-loss-reduce-the-risk-of-breast-cancer-a-meta-analysis-of-139-prospective-and-retrospective-studies
#13
Prue J Hardefeldt, Ross Penninkilampi, Senarath Edirimanne, Guy D Eslick
BACKGROUND: Physical activity and weight loss have been shown to reduce breast cancer incidence in numerous observational studies. The aim of this meta-analysis was to assess the effect of both physical activity and weight loss on breast cancer incidence. Specifically, we aimed to complete subgroup analyses by the intensity of physical activity and menopausal status at breast cancer diagnosis to further elucidate the relationship between physical activity, weight loss, and breast cancer incidence...
October 17, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29222878/non-communicable-diseases-food-and-nutrition-in-vietnam-from-1975-to-2015-the-burden-and-national-response
#14
Tuan T Nguyen, Minh V Hoang
BACKGROUND AND OBJECTIVES: This review manuscript examines the burden and national response to non-communicable diseases (NCDs), food and nutrition security in Vietnam from 1975 to 2015. METHODS AND STUDY DESIGN: We extracted data from peer-reviewed manuscripts and reports of nationally representative surveys and related policies in Vietnam. RESULTS: In 2010, NCDs accounted for 318,000 deaths (72% of total deaths), 6.7 million years of life lost, and 14 million disability-adjusted life years in Vietnam...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222610/characterizing-the-neighborhood-obesogenic-environment-in-the-multiethnic-cohort-a-multi-level-infrastructure-for-cancer-health-disparities-research
#15
Shannon M Conroy, Salma Shariff-Marco, Juan Yang, Andrew Hertz, Myles Cockburn, Yurii B Shvetsov, Christina A Clarke, Cheryl L Abright, Christopher A Haiman, Loïc Le Marchand, Laurence N Kolonel, Kristine R Monroe, Lynne R Wilkens, Scarlett Lin Gomez, Iona Cheng
PURPOSE: We characterized the neighborhood obesogenic environment in the Multiethnic Cohort (MEC) by examining the associations of obesity with attributes of the social and built environment, establishing a multi-level infrastructure for future cancer research. METHODS: For 102,906 African American, Japanese American, Latino, and white MEC participants residing predominately in Los Angeles County, baseline residential addresses (1993-1996) were linked to census and geospatial data, capturing neighborhood socioeconomic status (nSES), population density, commuting, food outlets, amenities, walkability, and traffic density...
December 8, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29219783/diet-and-other-lifestyle-factors-associated-with-prostate-cancer-differ-between-the-german-and-italian-region-of-switzerland
#16
Aline Richard, David Faeh, Matthias Bopp, Sabine Rohrmann
PURPOSE: In Switzerland, prostate cancer mortality is higher in the German than in the Italian-speaking region. We aimed at exploring the association of living in one of the two regions with lifestyle factors presumably lowering the risk of prostate cancer. METHODS: We pooled data from the Swiss Health Survey, conducted every 5 years 1992 - 2012. Information on diet (meat, fish, dairy, fruits and vegetables), alcohol, smoking, physical activity and body mass index were dichotomized into "risky" and "risk-reducing" lifestyle behaviour with respect to prostate cancer...
December 8, 2017: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/29218257/pulmonary-tuberculosis-versus-recurrent-chemotherapy-induced-pneumonitis-a-clinical-dilemma
#17
Gulrayz Ahmed, Muhammad W Saif
Chemotherapy-induced lung toxicity can affect pulmonary parenchyma, pleura, airways, pulmonary vascular system, mediastinum or the neuromuscular system that is responsible for respiration. Chemotherapy-induced pulmonary toxicity is a diagnosis of exclusion. When the patients with malignancies develop pulmonary toxicity such as pneumonitis and distinguishing it from alternative diseases such as infectious, thrombotic, cardiac, malignant or exacerbation of chronic lung conditions can be difficult. Moreover, such patients are often immunosuppressed, physically stressed from the underlying disease and the cancer treatment and hence, more susceptible to usual and unusual or opportunistic infections...
October 4, 2017: Curēus
https://www.readbyqxmd.com/read/29217211/mediating-effects-of-cancer-risk-factors-on-the-association-between-race-and-cancer-incidence-analysis-of-the-nih-aarp-diet-and-health-study
#18
Tomi Akinyemiju, Justin Xavier Moore, Maria Pisu
PURPOSE: Racial disparities exist in the prevalence of cancer-related risk factors and incidence of cancer. The objective of this study is to determine if cancer-related risk factors mediate the association between race and cancer incidence. METHODS: We performed prospective analysis of data from the National Institutes of Health-American Association of Retired Persons Diet and Health Study, years 1995 through 2011. We compared differences in baseline characteristics between black and white participants using χ2 tests and Wilcoxon tests, as appropriate...
November 23, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/29216311/amelioration-of-sexual-behavior-and-motor-activity-deficits-in-a-castrated-rodent-model-with-a-selective-androgen-receptor-modulator-sarm-2f
#19
Megumi Morimoto, Yuichiro Amano, Masahiro Oka, Ayako Harada, Hisashi Fujita, Yukiko Hikichi, Ryuichi Tozawa, Masuo Yamaoka, Takahito Hara
Sarcopenia and cachexia present characteristic features of a decrease in skeletal muscle mass and strength, anorexia, and lack of motivation. Treatments for these diseases have not yet been established, although selective androgen receptor modulators (SARMs) are considered as therapeutic targets. We previously reported that a novel SARM compound, SARM-2f, exhibits anabolic effect on muscles, with less stimulatory effect on prostate weight compared with testosterone, in rat Hershberger assays and cancer cachexia models...
2017: PloS One
https://www.readbyqxmd.com/read/29214834/source-and-size-of-social-support-network-on-sedentary-behavior-among-older-adults
#20
Paul D Loprinzi, Elizabeth A Crush
PURPOSE: To examine the association of source of social support and size of social support network on sedentary behavior among older adults. DESIGN: Cross-sectional. SETTING: National Health and Nutrition Examination Survey 2003 to 2006. PARTICIPANTS: 2519 older adults (60+ years). MEASURES: Sedentary behavior was assessed via accelerometry over a 7-day period. Social support was assessed via self-report...
January 1, 2017: American Journal of Health Promotion: AJHP
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