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Hanqiu Chen, Wen Zhang, Ning Yang, Chongmin Chen, Mingliang Zhang
The surface molecular imprinting technique has been proposed as a prospective strategy for template molecule recognition and separation by devising the recognition sites on the surface of imprinted materials. The purpose of this study was to establish a novel drug delivery system which was developed by surface molecular imprinting method using β-cyclodextrin (β-CD)-grafted chitosan (CS) (CS-g-β-CD) microspheres as matrix and sinomenine hydrochloride (SM) as the template molecule. By adjusting the amount of functional monomer and cross-linking agent, we got the more excellent adsorption of CS-g-β-CD molecularly imprinted polymers (MIPs-CS-g-β-CD)...
November 20, 2017: Applied Biochemistry and Biotechnology
Kevser Sevim, Jingzhe Pan
For aliphatic polyesters such as PLAs and PGAs, there is a strong interplay between the hydrolytic degradation and erosion - degradation leads to a critically low molecular weight at which erosion starts. This paper considers the underlying physical and chemical processes of hydrolytic degradation and erosion. Several kinetic mechanisms are incorporated into a mathematical model in an attempt to explain different behaviours of mass loss observed in experiments. In the combined model, autocatalytic hydrolysis, oligomer production and their diffusion are considered together with surface and interior erosion using a set of differential equations and Monte Carlo technique...
November 8, 2017: Acta Biomaterialia
Ahmad Alsarah, Osama Alsara, Heather S Laird-Fick
Familial Mediterranean fever (FMF) is autoinflammatory disorder characterized by sporadic attacks of fever, peritonitis, pleuritis, and arthritis. It is mainly seen in patients from Mediterranean origins, but it is now reported more frequently in Europe and North America due to immigration. To analyze the data on the cardiovascular manifestations in FMF patients, we searched PubMed using the terms "Familial Mediterranean Fever" or "FMF" in combination with other key words including "cardiovascular diseases" "pericardial diseases" "atherosclerosis" "coronary artery diseases" "cardiomyopathy" "pulmonary hypertension" or "valvular diseases...
October 2017: Avicenna Journal of Medicine
Menghua Li, Guilin Shan, Haiyang Zhou, Wolfgang Buescher, Christian Maack, Kerstin H Jungbluth, André Lipski, David A Grantz, Youheng Fan, Daokun Ma, Zhongyi Wang, Qiang Cheng, Yurui Sun
Silage is a critical global feedstock, but is prone to aerobic deterioration. The dominant mechanism of O2 transport into silage remains unresolved. Here, multiple sensors tracked O2 and CO2, gas pressure (ΔP) between internal silage and ambient air, pH and silage temperature (Tsi) during the ensilage of maize and ryegrass. We report the first observation that CO2 produced from microbial respiration was partially dissolved in silage water, with evidence of negative or positive ΔP depending on the changing balance between CO2 production and dissolution...
November 7, 2017: Scientific Reports
Nikki L Hill, Jacqueline Mogle, Rachel Wion, Ann M Kolanowski, Donna Fick, Liza Behrens, Paula Muhall, Jane McDowell
BACKGROUND: Research assistants (RAs) are critical members of all research teams. When a study involves vulnerable populations, it is particularly important to have the right team members. AIM: To describe the motivations, personal characteristics and team characteristics that promoted the job satisfaction of RAs who worked on two multi-year, randomised clinical trials involving older adults with dementia. DISCUSSION: A survey was conducted with 41 community members who worked as RAs for up to five years...
September 19, 2017: Nurse Researcher
Lilit Karapetyan, Manoj Rai, Om Dawani, Heather S Laird-Fick
BACKGROUND: Sarcomatoid squamous cell carcinoma is a rare and aggressive form of cervical cancer. We report a case of metastatic sarcomatoid squamous cell carcinoma (SSCC) of cervix that presented with an anterior chest wall mass. CASE: A 43-year-old Hispanic female presented with a two-month history of a central chest wall mass. The patient's only past medical history was SSCC of the cervix, stage IIB, diagnosed two years priorly. She underwent neoadjuvant chemoradiation therapy (CRT) with cisplatin followed by radical hysterectomy...
2017: Case Reports in Oncological Medicine
Daniel L Christensen, Kyle E Nappo, Benjamin Ficke, Scott M Tintle
PURPOSE: The purpose of this study was to determine the frequency with which osteoporosis topics (screening, medical treatment, and fracture prevention) are presented at national hand surgery meetings. This was compared with the frequency of the same topics presented at the Orthopaedic Trauma Association (OTA) annual meetings. METHODS: The annual meeting programs for the American Society for Surgery of the Hand (ASSH), the American Association for Hand Surgery (AAHS), and the OTA from the previous 10 years (2007-2016) were searched for presentations that covered bone health at each of these meetings...
October 18, 2017: Journal of Hand Surgery
GwangSik Park, Dongsik Han, GwangSu Kim, Seungwoo Shin, Kyoohyun Kim, Je-Kyun Park, YongKeun Park
Microfluidic mixing plays a key role in various fields, including biomedicine and chemical engineering. To date, although various approaches for imaging microfluidic mixing have been proposed, they provide only quantitative imaging capability and require exogenous labeling agents. Quantitative phase imaging techniques, however, circumvent these problems and offer label-free quantitative information about concentration maps of microfluidic mixing. We present the quantitative phase imaging of microfluidic mixing in various types of polydimethylsiloxane microfluidic channels with different geometries; the feasibility of the present method was validated by comparing it with the results obtained by theoretical calculation based on Fick's law...
August 1, 2017: Applied Optics
Michal Schäfer, Uyen Truong, Lorna P Browne, Gareth J Morgan, Michael Ross, Richard Ing, Kendall S Hunter, Vitaly O Kheyfets, Steven H Abman, D Dunbar Ivy, Neil Wilson
We sought to compare pulmonary flow hemodynamic indices obtained by Fick and thermodilution catheterization techniques with phase-contrast MRI (PC-MRI) in children with diverse etiologies of pulmonary arterial hypertension (PAH). Calculation of pulmonary flow ([Formula: see text]) using the Fick principle in most catheter laboratories relies on an estimate of oxygen consumption which may limit its reliability. Flow hemodynamic indices acquired from thirty patients with PAH who underwent successful same-day PC-MRI and catheterization were evaluated for absolute and percent bias...
October 17, 2017: Pediatric Cardiology
A Lagesson, T Brodin, J Fahlman, J Fick, M Jonsson, J Persson, P Byström, J Klaminder
An increasing number of short-term laboratory studies on fish reports behavioral effects from exposure to aquatic contaminants or raised carbon dioxide levels affecting the GABAA receptor. However, how such GABAergic behavioral modifications (GBMs) impact populations in more complex natural systems is not known. In this study, we induced GBMs in European perch (Perca fluviatilis) via exposure to a GABA agonist (oxazepam) and followed the effects on growth and survival over one summer (70days) in replicated pond ecosystems...
February 15, 2018: Science of the Total Environment
Alexander M Berezhkovskii, Leonardo Dagdug, Sergey M Bezrukov
We study transitions of diffusing particles between the left and right ends of expanding and narrowing conical tubes. In an expanding tube, such transitions occur faster than in the narrowing tube of the same length and radius variation rate. This happens because the entropy potential pushes the particle towards the wide tube end, thus accelerating the transitions in the expanding tube and slowing them down in the narrowing tube. To gain deeper insight into how the transitions occur, we divide each trajectory into the direct-transit and looping segments...
October 7, 2017: Journal of Chemical Physics
Barbara Wiśniowska, Zofia Tylutki, Sebastian Polak
The utilization of mathematical modeling and simulation in drug development encompasses multiple mathematical techniques and the location of a drug candidate in the development pipeline. Historically speaking they have been used to analyze experimental data (i.e., Hill equation) and clarify the involved physical and chemical processes (i.e., Fick laws and drug molecule diffusion). In recent years the advanced utilization of mathematical modeling has been an important part of the regulatory review process. Physiologically based pharmacokinetic (PBPK) models identify the need to conduct specific clinical studies, suggest specific study designs and propose appropriate labeling language...
2017: Frontiers in Physiology
Rutger H J Fick, Alexandra Petiet, Mathieu Santin, Anne-Charlotte Philippe, Stephane Lehericy, Rachid Deriche, Demian Wassermann
Effective representation of the four-dimensional diffusion MRI signal - varying over three-dimensional q-space and diffusion time τ - is a sought-after and still unsolved challenge in diffusion MRI (dMRI). We propose a functional basis approach that is specifically designed to represent the dMRI signal in this qτ-space. Following recent terminology, we refer to our qτ-functional basis as "qτ-dMRI". qτ-dMRI can be seen as a time-dependent realization of q-space imaging by Paul Callaghan and colleagues. We use GraphNet regularization - imposing both signal smoothness and sparsity - to drastically reduce the number of diffusion-weighted images (DWIs) that is needed to represent the dMRI signal in the qτ-space...
September 14, 2017: Medical Image Analysis
Mengyue Gong, Yuruihan Wang, Amarjeet Bassi
Lutein is a commercial carotenoid with potential health benefits. Microalgae are alternative sources for the lutein production in comparison to conventional approaches using marigold flowers. In this study, a process analysis of a single-step simultaneous extraction, saponification, and primary purification process for free lutein production from wet microalgae biomass was carried out. The feasibility of binary solvent mixtures for wet biomass extraction was successfully demonstrated, and the extraction kinetics of lutein from chloroplast in microalgae were first evaluated...
September 30, 2017: Applied Microbiology and Biotechnology
Randall P Wagner, Steven E Fick
This article reports the first use of the pressure reciprocity technique to calibrate a micro-electromechanical system (MEMS) microphone. This standardized primary calibration method is conventionally used to calibrate laboratory standard microphones. Results for the pressure reciprocity calibration of a MEMS microphone and two laboratory standard microphones are presented for the frequency range 100-10 000 Hz. Because the amplifier in the MEMS microphone package prevents reciprocal operation, this microphone was used only as a receiver of sound...
September 2017: Journal of the Acoustical Society of America
Vy Anh Tran, Sang-Wha Lee
This work demonstrated kinetically controlled release of model drugs (ibuprofen, FITC) from well-tailored mesoporous silica nanoparticles (MSNs) depending on the surface charges and molecular sizes of the drugs. The molecular interactions between entrapped drugs and the pore walls of MSNs controlled the release of the drugs through the pore channels of MSNs. Also, polydopamine (PDA) layer-coated MSNs (MSNs@PDA) was quite effective to retard the release of large FITC, in contrast to a slight retardation effect on relatively small Ibuprofen...
January 15, 2018: Journal of Colloid and Interface Science
Catie Christensen, Lori Fickes
No abstract text is available yet for this article.
October 2017: Pediatric Physical Therapy
Suyun Li, Haile Ma, Yiting Guo, Ayobami Olayemi Oladejo, Xue Yang, Qiufang Liang, Yuqing Duan
The aim of this study was to establish a new model to reflect the real ultrasound pretreatment process on rice protein (RP). In this study, ultrasound treatment affected the yield of soluble protein of RP significantly and also improved the enzymatic hydrolysis efficiently. However, the aggregation of soluble protein occurred when ultrasonic power density and temperature reached a high level. The traditional model cannot reflect the real pretreatment process on RP due to the aggregation of protein. In this paper, a modified kinetic model was thus established by introducing a parameter of aggregation coefficient based on the Fick's second law, suggesting the two coefficients were highly dependent on the ultrasonic power density and temperature...
January 2018: Ultrasonics Sonochemistry
Ciara K McDonnell, Paul Allen, Gearoid Duane, Charlotte Morin, Eoin Casey, James G Lyng
A one-directional modelling method for the assessment of the influence of power ultrasound (US) (4-19Wcm(-2), 25-40min) on NaCl diffusion in pork is presented. In doing so, the mechanistic actions of US salting in meat are elucidated. Temperature controls (4-21°C) were generated according to each US treatment. NaCl concentration profiles were fitted to Fick's second law, generating the effective NaCl diffusion coefficient (Dseff). Dseff ranged from 1.34×10(-10) to 4.01×10(-10)m(2)s(-1), which is in agreement with the literature...
January 2018: Ultrasonics Sonochemistry
Amit Tripathi, Chunxiang Wei, Klaus Tauer
The assumption that during emulsion polymerization, the monomer molecules simply diffuse through the aqueous phase into the latex particles is a commonplace. However, there are experimental hints that this might not be that easy. Here, simulation results are discussed based on Fick's diffusion laws regarding the swelling of latex particles. The results of quantitative application of these laws for swelling of latex particles allow the conclusion that the instantaneous replenishment of the consumed monomer during emulsion polymerization requires a close contact between the monomer and the polymer particles...
2017: Colloid and Polymer Science
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