Read by QxMD icon Read


Tyler Fick, Julie Jack, Amy L Pyle-Eilola, Rohan K Henry
BACKGROUND: Severe hypertriglyceridemia (HTG) as well as diabetic ketoacidosis (DKA) are complications of type 1 diabetes (T1DM). HTG is an exceedingly rare complication in the pediatric population and herein we report a case of HTG at new-onset T1DM in DKA and discuss management and potential complications. CASE PRESENTATION: An 11-year-old previously well patient with a history of fatigue and weight loss presented with: glucose >600 mg/dL, venous blood gas: pH 7...
July 25, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
Michael D Seckeler, Katri Typpo, Jendar Deschenes, Ruth Higgins, Ricardo Samson, Peter Lichtenthal
OBJECTIVE: To determine the accuracy of a continuous cardiac output monitor (FloTrac sensor) for measuring cardiac index in children with congenital heart disease undergoing cardiac catheterization. Cardiac index is a critical hemodynamic parameter measured during catheterizations in children with congenital heart disease. This has been challenging to measure accurately and many clinicians rely on predictive equations for calculating cardiac index. DESIGN: Prospective, nonrandomized trial...
July 18, 2017: Congenital Heart Disease
Marina Kolbina, Roland Bodmeier, Martin Körber
The aim of this study was to evaluate the suitability of saturated phosphatidylcholine (Phospholipon® 90H) as extended release excipient in matrix tablets for three model drugs with different aqueous solubility (theophylline, caffeine and diprophylline). The tablets could be prepared by direct compression because of the favorable phospholipid powder flow properties (Carr's index: 12.64 and angle of repose: 28.85) and good compactibility. Tablets of low porosity were formed already at low pressure of 40MPa and with drug loadings up to 70% due to high plasticity of the phospholipid...
July 14, 2017: European Journal of Pharmaceutical Sciences
S A Berzins, A G Bulloch, J M Burton, K S Dobson, G H Fick, S B Patten
OBJECTIVE: To estimate the incidence and explore potential determinants of incidence of depression in MS. METHODS: A prospective cohort study used a sample of 192 patients from the southern Alberta MS clinic registry. Participants completed baseline risk factor assessment questionnaires using either online, mail or telephone surveys, and completed the Patient Health Questionnaire every 2weeks for 6months to assess depressive symptoms in real time. Risk factors assessed included biopsychosocial variables such as socioeconomic status, illness-related factors, childhood risk factors, psychosocial factors, and health behaviors...
August 2017: Journal of Psychosomatic Research
Haixiang Hu, Yanfei Xing, Xiaochun Li
Storing CO2 in underground saline aquifers is an important way to reduce CO2 emission in atmosphere, where gas/fluid diffusion in clay plays a key role in CO2 leakage and migration. Various diffusivities, self-diffusivity, Maxwell-Stefan (M-S) diffusivity and Fick diffusivity, in clay interlayer are investigated by molecular dynamics (MD). Self-diffusivity varies with CO2 concentration, and reaches the maximum value at 2 molecules/unit-cell. High fluid concentration leads to clay swelling, thereby increasing self-diffusivity...
July 14, 2017: Scientific Reports
Michele Caputo, Cesare Cametti
In this note, we present a simple mathematical model of drug delivery through transdermal patches by introducing a memory formalism in the classical Fick diffusion equation based on the fractional derivative. This approach is developed in the case of a medicated adhesive patch placed on the skin to deliver a time released dose of medication through the skin towards the bloodstream.The main resistance to drug transport across the skin resides in the diffusion through its outermost layer (the stratum corneum)...
July 11, 2017: Mathematical Biosciences
Silvia Tavazzi, Alessandra Rossi, Sara Picarazzi, Miriam Ascagni, Stefano Farris, Alessandro Borghesi
Soft contact lenses used for the correction of ametropia are often made of hydrogel and silicone-hydrogel materials. Since they are placed directly on the surface of the eye and they are hydrated by tears, eye cosmetics can compromise the lens performance and, even worse, can be transported from an external environment to the ocular surface through the contact lens. The diffusion of the dye component of a purple eyeshadow in soft contact lenses of different materials is here evaluated. Diffusivity is found to be typically higher in silicone-hydrogels than in hydrogels...
July 7, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
Steven Hsu, Samuel B Brusca, Parker S Rhodes, Todd M Kolb, Stephen C Mathai, Ryan J Tedford
Two new definitions of exercise-induced pulmonary hypertension (EIPH) have emerged. Both rely on measuring cardiac output (CO), yet this remains unstandardized. In our cohort of patients undergoing invasive cardiopulmonary exercise testing, we found that using thermodilution CO rather than direct Fick CO led to a significant excess of EIPH diagnoses.
March 2017: Pulmonary Circulation
Tomohiko Kisaka, William W Stringer, Akira Koike, Piergiuseppe Agostoni, Karlman Wasserman
Oxygen uptake (V̇O2) measured at the mouth, which is equal to the cardiac output (C.O.) times the arterial-venous oxygen content difference [C(a-v)O2) ], increases over 10-20 fold in normal subjects during exercise. To achieve this substantial increase in oxygen uptake (V̇O2) = C.O. x C(a-v)O2) ) both cardiac output and arterial-venous difference must simultaneously increase. While this occurs in normal subjects, patients with heart failure cannot achieve significant increases in cardiac output and must rely primarily on changes in arterial-venous difference to increase V̇O2) during exercise...
July 5, 2017: Annals of the American Thoracic Society
Erin S McCallum, Emily Krutzelmann, Tomas Brodin, Jerker Fick, Anna Sundelin, Sigal Balshine
Pharmaceutical active compounds (PhACs) are increasingly being reported in wastewater effluents and surface waters around the world. The presence of these products, designed to modulate human physiology and behaviour, has created concern over whether PhACs similarly affect aquatic organisms. Though laboratory studies are beginning to address the effects of individual PhACs on fish behaviour, few studies have assessed the effects of exposure to complex, realistic wastewater effluents on fish behaviour. In this study, we exposed a wild, invasive fish species-the round goby (Neogobius melanostomus)-to treated wastewater effluent (0%, 50% or 100% effluent dilutions) for 28days...
June 30, 2017: Science of the Total Environment
Lisa Racine, Aynur Guliyeva, Irène Wang, Véronique Larreta-Garde, Rachel Auzély-Velty, Isabelle Texier
A hybrid hydrogel composed of solid lipid nanoparticles (LNPs) entrapped within chemically cross-linked carboxymethylcellulose (CMC) is developed to achieve localized and sustained release of lipophilic drugs. The analysis of LNP stability as well as the hydrogel swelling and mechanical properties confirm the successful incorporation of particles up to a concentration of 50% w/wCMC . The initial LNP release rate can be prolonged by increasing the particle diameter from 50 to 120 nm, while the amount of long-term release can be adjusted by tailoring the particle surface charge or the cross-linking density of the polymer...
July 3, 2017: Macromolecular Bioscience
Andrea Yevchak, Donna M Fick, Ann M Kolanowski, Jane McDowell, Todd Monroe, Anna LeViere, Lorraine Mion
Little is understood about the use of person-centered care (PCC) for individuals with delirium superimposed on dementia (DSD), especially in the acute care setting. As part of a larger clinical trial, the purpose of the current exploratory study was to describe examples and qualitatively derived themes of nurse-facilitated PCC for hospitalized older adults with dementia and delirium. A total of 750 delirium rounds were analyzed across three diverse acute care sites. Qualitative derived themes of PCC included: (a) Knowing the Patient's Baseline; (b) Knowing the Patient's Interests and Values; (c) Enhancing Sensory Abilities to Communicate; (d) Individualizing Cognitive Stimulation; and (e) Enhancing Behavioral Approaches to Comfort and Sleep...
June 26, 2017: Journal of Gerontological Nursing
Christine Peters, Ludger Wolff, Sandra Haase, Julia Thien, Thorsten Brands, Hans-Jürgen Koß, André Bardow
Diffusion is slow. Thus, diffusion experiments are intrinsically time-consuming and laborious. Additionally, the experimental effort is multiplied for multicomponent systems as the determination of multicomponent diffusion coefficients typically requires several experiments. To reduce the experimental effort, we present the first microfluidic diffusion measurement method for multicomponent liquid systems. The measurement setup combines a microfluidic chip with Raman microspectroscopy. Excellent agreement between experimental results and literature data is achieved for the binary system cyclohexane + toluene and the ternary system 1-propanol + 1-chlorobutane + heptane...
June 29, 2017: Lab on a Chip
Ronja Wonneberger, Andrea Ficke, Morten Lillemo
Association mapping of resistance to Pyrenophora teres f. teres in a collection of Nordic barley germplasm at different developmental stages revealed 13 quantitative loci with mostly small effects. Net blotch, caused by the necrotrophic fungus Pyrenophora teres, is one of the major diseases in barley in Norway causing quantitative and qualitative yield losses. Resistance in Norwegian cultivars and germplasm is generally insufficient and resistance sources have not been extensively explored yet. In this study, we mapped quantitative trait loci (QTL) associated with resistance to net blotch in Nordic germplasm...
June 26, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Serge Savary, Annika Djurle, Jonathan Yuen, Andrea Ficke, Vittorio Rossi, Paul Esker, Jose M Fernandes, Emerson Del Ponte, Jatindra Kumar, Laurence V Madden, Pierce A Paul, Neil McRoberts, Pawan Kumar Singh, Laurent Huber, Claude Pope de Vallavieille, Sébastien Saint-Jean, Laetitia Willocquet
Scenario analysis constitutes a useful approach to synthesize knowledge and derive hypotheses in the case of complex systems which are documented with mainly qualitative or very diverse information. In this article, a framework for scenario analysis is designed and then, applied to global wheat health within a timeframe from today to 2050. Scenario analysis entails the choice of settings, the definition of scenarios of change, and the analysis of outcomes of these scenarios in the chosen settings. Three idealized agrosystems, representing a large fraction of the global diversity of wheat-based agrosystems, are considered, which represent the settings of the analysis...
June 23, 2017: Phytopathology
Uran Ferizi, Benoit Scherrer, Torben Schneider, Mohammad Alipoor, Odin Eufracio, Rutger H J Fick, Rachid Deriche, Markus Nilsson, Ana K Loya-Olivas, Mariano Rivera, Dirk H J Poot, Alonso Ramirez-Manzanares, Jose L Marroquin, Ariel Rokem, Christian Pötter, Robert F Dougherty, Ken Sakaie, Claudia Wheeler-Kingshott, Simon K Warfield, Thomas Witzel, Lawrence L Wald, José G Raya, Daniel C Alexander
A large number of mathematical models have been proposed to describe the measured signal in diffusion-weighted (DW) magnetic resonance imaging (MRI). However, model comparison to date focuses only on specific subclasses, e.g. compartment models or signal models, and little or no information is available in the literature on how performance varies among the different types of models. To address this deficiency, we organized the 'White Matter Modeling Challenge' during the International Symposium on Biomedical Imaging (ISBI) 2015 conference...
June 23, 2017: NMR in Biomedicine
Diego Caccavo, Gaetano Lamberti, Anna Angela Barba, Susanna Abrahmsén-Alami, Anna Viridén, Anette Larsson
The purpose of this study was to investigate the hydration behavior of two matrix formulations containing the cellulose derivative hydroxypropyl methylcellulose (HPMC). The two HPMC batches investigated had different substitution pattern along the backbone; the first one is referred to as heterogeneous and the second as homogenous. The release of both the drug molecule theophylline and the polymer was determined. Additionally, the water concentrations at different positions in the swollen gel layers were determined by Magnetic Resonance Imaging...
June 19, 2017: International Journal of Pharmaceutics
Donna M Fick, Andrew D Auerbach, Michael S Avidan, Jan Busby-Whitehead, E Wesley Ely, Richard N Jones, Edward R Marcantonio, Dale M Needham, Pratik Pandharipande, Thomas N Robinson, Eva M Schmitt, Thomas G Travison, Sharon K Inouye
No abstract text is available yet for this article.
June 20, 2017: Journal of the American Geriatrics Society
P V Hunter, M Delbaere, M E O'Connell, A Cammer, J X Seaton, T Friedrich, F Fick
BACKGROUND: One of the most common uses of the Internet is to search for health-related information. Although scientific evidence pertaining to cognitive health promotion has expanded rapidly in recent years, it is unclear how much of this information has been made available to Internet users. Thus, the purpose of our study was to assess the reliability and quality of information about cognitive health promotion encountered by typical Internet users. METHODS: To generate a list of relevant search terms employed by Internet users, we entered seed search terms in Google Trends and recorded any terms consistently used in the prior 2 years...
June 15, 2017: BMC Geriatrics
Aldo Ledesma-Durán, S I Hernández, Iván Santamaría-Holek
In this work, we provide a theoretical relationship between the spatial-dependent diffusion coefficient derived in the Fick-Jacobs (FJ) approximation and the macroscopic diffusion coefficient of a membrane that depends on the porosity, tortuosity, and the constriction factors. Based on simple mass conservation arguments under equilibrium as well as in nonequilibrium conditions, we generalize previous expressions for the effective diffusion coefficient of an irregular pore, originally obtained by Festa and d'Agliano for horizontal and periodic pores, and then extended by Bradley for tortuous periodic pores, to the case of pores with arbitrary geometry...
May 2017: Physical Review. E
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"