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https://www.readbyqxmd.com/read/29040803/synthesis-and-characterization-of-fatty-acid-grafted-chitosan-polymer-and-their-nanomicelles-for-non-viral-gene-delivery-applications
#1
Divya Sharma, Jagdish Singh
The aim of this study was to synthesize and characterize fatty acid-grafted-chitosan (fatty acid-g-CS) polymer and their nanomicelles for using as carriers for gene delivery. CS was hydrophobically modified using saturated fatty acids of increasing fatty acyl chain length. Carbodiimide along with N-hydroxysuccinimide was used for coupling carboxyl group of fatty acids with amine groups of CS. Proton nuclear magnetic resonance and Fourier transform-infrared spectroscopy were used to quantify fatty acyl substitution onto CS backbone...
October 17, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29036931/mass-spectrometric-studies-of-apolipoprotein-proteoforms-and-their-role-in-lipid-metabolism-and-type-2-diabetes
#2
REVIEW
Dobrin Nedelkov
Apolipoproteins function as structural components of lipoprotein particles, cofactors for enzymes, and ligands for cell-surface receptors. Most of the apoliporoteins exhibit proteoforms, arising from single nucleotide polymorphisms (SNPs) and post-translational modifications such as glycosylation, oxidation, and sequence truncations. Reviewed here are recent studies correlating apolipoproteins proteoforms with the specific clinical measures of lipid metabolism and cardiometabolic risk. Targeted mass spectrometric immunoassays toward apolipoproteins A-I, A-II, and C-III were applied on large cross-sectional and longitudinal clinical cohorts...
October 15, 2017: Proteomes
https://www.readbyqxmd.com/read/29035738/thrombin-activatable-fluorescent-peptide-incorporated-gold-nanoparticles-for-dual-optical-computed-tomography-thrombus-imaging
#3
Sung-Pil Kwon, Sangmin Jeon, Sung-Hoon Lee, Hong Yeol Yoon, Ju Hee Ryu, Dayil Choi, Jeong-Yeon Kim, Jiwon Kim, Jae Hyung Park, Dong-Eog Kim, Ick Chan Kwon, Kwangmeyung Kim, Cheol-Hee Ahn
Thrombosis is an important pathophysiologic phenomenon in various cardiovascular diseases, which can lead to oxygen deprivation and infarction of tissues by generation of a thrombus. Thus, direct thrombus imaging can provide beneficial in diagnosis and therapy of thrombosis. Herein, we developed thrombin-activatable fluorescent peptide (TAP) incorporated silica-coated gold nanoparticles (TAP-SiO2@AuNPs) for direct imaging of thrombus by dual near-infrared fluorescence (NIRF) and micro-computed tomography (micro-CT) imaging, wherein TAP molecules were used as targeted thrombin-activatable peptide probes for thrombin-specific NIRF imaging...
October 9, 2017: Biomaterials
https://www.readbyqxmd.com/read/29032674/doxorubicin-loaded-unimolecular-micelles-stabilized-gold-nanoparticles-as-a-theranostic-nanoplatform-for-tumor-targeted-chemotherapy-and-ct-imaging
#4
Wenjing Lin, Xiaofang Zhang, Long Qian, Na Yao, Ya Pan, Lijuan Zhang
Current researches are mainly trend to address the development of multi-functional nanocarriers which could precisely reach the disease sites, release drugs in a controlled-manner and act as an imaging agent for both diagnosis and targeted therapy. In this study, a pH-sensitive theranostic nanoplatform as a promising dual-functional nanovector for tumor therapy and CT imaging was developed. 21-arm star like triblock polymerof β-cyclodextrin-{poly(-caprolactone)-poly(2-aminoethyl methacrylate)-poly[poly(ethylene glycol) methyl ether methacrylate]}21 [β-CD-(PCL-PAEMA-PPEGMA)21] with stable unimolecular micelles formed in aqueous solution was firstly synthesized by combined ROP with ARGET ATRP techniques, and then were used as template for fabrication of gold nanoparticles (AuNPs) with uniform sizes and excellent colloidal stability in situ, followed by the encapsulation of doxorubicin (DOX) with maximum entrapment efficiency up to 60% to generate the final product β-CD-(PCL-PAEMA-PPEGMA)21/AuNPs/DOX...
October 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29031927/particle-radiotherapy-a-novel-external-radiation-therapy-versus-liver-resection-for-hepatocellular-carcinoma-accompanied-with-inferior-vena-cava-tumor-thrombus-a-matched-pair-analysis
#5
Shohei Komatsu, Masahiro Kido, Sadaki Asari, Hirochika Toyama, Tetsuo Ajiki, Yusuke Demizu, Kazuki Terashima, Tomoaki Okimoto, Ryohei Sasaki, Takumi Fukumoto
BACKGROUND: Hepatocellular carcinoma accompanied with inferior vena cava tumor thrombus carries a dismal prognosis, and the feasibility of local treatment has remained controversial. The present study aimed to compare the outcomes of particle radiotherapy and liver resection in patients with hepatocellular carcinoma with inferior vena cava tumor thrombus. METHODS: Thirty-one and 19 patients, respectively, underwent particle radiotherapy and liver resection for hepatocellular carcinoma with inferior vena cava tumor thrombus...
October 11, 2017: Surgery
https://www.readbyqxmd.com/read/29031203/local-anaesthetic-pain-relief-therapy-in-vitro-and-in-vivo-evaluation-of-a-nanotechnological-formulation-co-loaded-with-ropivacaine-and-dexamethasone
#6
Yongxin Zhang, Yaocun Yue, Meng Chang
Combination therapy is frequently applied to anesthesia and analgesia for its benefits, which includes prolonged analgesia following peripheral nerve blockade, and reduced side effects. The aim of this study was to develop chitosan (CH) coated poly(ε-caprolactone) (PCL) nanoparticles to co-deliver ropivacaine (RPV) and dexamethasone (DEM) (RPV/DEM CH-PCL NPs) for the prolongation of anesthesia and pain relief. In the present study, RPV/DEM CH-PCL NPs were fabricated. The properties of CH-PCL NPs were evaluated for their particle sizes, zeta potential, drug loading capacity and in vitro drug release profile...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29029165/depicting-new-pharmacological-strategies-for-familial-hypercholesterolaemia-involving-lipoprotein-a
#7
Alpo Vuorio, Gerald F Watts, Petri T Kovanen
Approximately 35 million people worldwide suffer from heterozygous familial hypercholesterolaemia (HeFH), a condition characterized by genetically determined life-long elevation of plasma low-density lipoprotein cholesterol (LDL-C). One in three of these patients also inherit an elevated plasma concentration of lipoprotein (a) [Lp(a)], a lipoprotein particle with atherogenic, inflammatory and prothrombotic properties. Accordingly, the combination of high plasma LDL-C and Lp(a) can markedly accelerate premature atherosclerotic cardiovascular disease (ASCVD)...
October 3, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29027985/triterpenoids-from-ocimum-labiatum-activates-latent-hiv-1-expression-in-vitro-potential-for-use-in-adjuvant-therapy
#8
Petrina Kapewangolo, Justin J Omolo, Pascaline Fonteh, Martha Kandawa-Schulz, Debra Meyer
Latent HIV reservoirs in infected individuals prevent current treatment from eradicating infection. Treatment strategies against latency involve adjuvants for viral reactivation which exposes viral particles to antiretroviral drugs. In this study, the effect of novel triterpenoids isolated from Ocimum labiatum on HIV-1 expression was measured through HIV-1 p24 antigen capture in the U1 latency model of HIV-1 infection and in peripheral blood mononuclear cells (PBMCs) of infected patients on combination antiretroviral therapy (cART)...
October 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29026613/a-case-of-generalized-argyria-presenting-with-muscle-weakness
#9
Inha Jung, Eun-Jeong Joo, Byung Seong Suh, Cheol-Bae Ham, Ji-Min Han, You-Gyung Kim, Joon-Sup Yeom, Ju-Yeon Choi, Ji-Hye Park
BACKGROUND: Argyria is a rare irreversible cutaneous pigmentation disorder caused by prolonged exposure to silver. Herein, we report a case of generalized argyria that developed after chronic ingestion of soluble silver-nano particles and presented with muscle weakness. CASE PRESENTATION: A 74-year-old woman visited our emergency room, complaining of fever and mental deterioration. She was diagnosed with acute pyelonephritis and recovered after antibiotic therapy...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29025661/low-systemic-toxicity-nanocarriers-fabricated-from-heparin-mpeg-and-pamam-dendrimers-for-controlled-drug-release
#10
Vu Minh Thanh, Thi Hiep Nguyen, Tuong Vi Tran, Uyen-Thi Phan Ngoc, Minh Nhat Ho, Thi Thinh Nguyen, Yen Nguyen Tram Chau, Van Thu Le, Ngoc Quyen Tran, Cuu Khoa Nguyen, Dai Hai Nguyen
In this report, poly(amide amine) (PAMAM) dendrimer and Heparin-grafted-monomethoxy polyethylene glycol (HEP-mPEG) were synthesized and characterized. In aqueous solution, the generation 4 PAMAM dendrimers (G4.0-PAMAM) existed as nanoparticles with particle size of 5.63nm. However, after electrostatic complexation with HEP-mPEG to form a core@shell structure G4.0-PAMAM@HEP-mPEG, the size of nanoparticles was significantly increased (73.82nm). The G4.0-PAMAM@HEP-mPEG nanoparticles showed their ability to effectively encapsulate doxorubicin (DOX) for prolonged and controlled release...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025645/enhancing-the-anti-gastric-cancer-activity-of-curcumin-with-biocompatible-and-ph-sensitive-pmma-aa-zno-nanoparticles
#11
Raman Dhivya, Jothi Ranjani, Jeyaprakash Rajendhran, Jeyanthinath Mayandi, Jamespandi Annaraj
Curcumin loaded ZnO nanoparticles were successfully synthesised and encapsulated with co-polymer PMMA-AA (Cur/PMMA-AA/ZnO NPs). The ZnO nanoparticles have been converted as good cargo materials to carry the well-known hydrophobic drug curcumin by surface functionalization. Physical characteristics of these novel nanomaterials have been studied with transmission electron microscopy (TEM) and powder X-ray diffraction (XRD) in conjunction with spectral techniques. A narrow particle size distribution with an average value of 42nm was found via TEM...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29023595/actinide-bioimaging-in-tissues-comparison-of-emulsion-and-solid-track-autoradiography-techniques-with-the-iqid-camera
#12
Stephanie Lamart, Brian W Miller, Anne Van der Meeren, Anissa Tazrart, Jaime F Angulo, Nina M Griffiths
This work presents a comparison of three autoradiography techniques for imaging biological samples contaminated with actinides: emulsion-based, plastic-based autoradiography and a quantitative digital technique, the iQID camera, based on the numerical analysis of light from a scintillator screen. In radiation toxicology it has been important to develop means of imaging actinide distribution in tissues as these radionuclides may be heterogeneously distributed within and between tissues after internal contamination...
2017: PloS One
https://www.readbyqxmd.com/read/29023522/microencapsulation-of-clostridium-difficile-specific-bacteriophages-using-microfluidic-glass-capillary-devices-for-colon-delivery-using-ph-triggered-release
#13
Gurinder K Vinner, Goran T Vladisavljević, Martha R J Clokie, Danish J Malik
The prevalence of pathogenic bacteria acquiring multidrug antibiotic resistance is a global health threat to mankind. This has motivated a renewed interest in developing alternatives to conventional antibiotics including bacteriophages (viruses) as therapeutic agents. The bacterium Clostridium difficile causes colon infection and is particularly difficult to treat with existing antibiotics; phage therapy may offer a viable alternative. The punitive environment within the gastrointestinal tract can inactivate orally delivered phages...
2017: PloS One
https://www.readbyqxmd.com/read/29023105/specific-detection-of-carcinoembryonic-antigen-based-on-fluorescence-quenching-of-hollow-porous-gold-nanoshells-with-roughened-surface
#14
Ting-Yang Xing, Jing Zhao, Guo-Jun Weng, Jian Zhu, Jian-Jun Li, Jun-Wu Zhao
The detection of tumor biomarkers in the early stage is highly desirable for the therapy of cancer. However, rapid, low-cost, sensitive, and selective detection of biomarkers remains a challenge owing to the sequence homology, short length, and low abundance. This Research Article describes the synthesis of a novel carcinoembryonic antigen (CEA) probe using hollow porous gold nanoparticles (HPGNPs) with roughened surface based on fluorescence quenching. For specific detection of CEA, the surface of HPGNP is modified by carboxyl modification, carboxyl activation, and antibody conjugation...
October 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29021325/high-density-lipoprotein-subclasses-coronary-artery-disease-and-cardiovascular-mortality
#15
Günther Silbernagel, Philipp Pagel, Volker Pfahlert, Bernd Genser, Hubert Scharnagl, Marcus E Kleber, Graciela Delgado, Haruna Ohrui, Andreas Ritsch, Tanja B Grammer, Wolfgang Koenig, Winfried März
BACKGROUND: The inverse relationship between HDL cholesterol and cardiovascular mortality is weakened in coronary artery disease (CAD). We aimed to investigate the associations of HDL particle concentrations with cardiovascular mortality and the impact of CAD on these associations. We also sought to comparatively evaluate HDL cholesterol and HDL particle concentrations in predicting cardiovascular mortality. METHODS: Total and subclass HDL particle concentrations were measured by nuclear magnetic resonance spectroscopy in 2290 participants of the LUdwigshafen RIsk and Cardiovascular Health study referred for coronary angiography...
October 11, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29019337/monte-carlo-simulation-of-beta-particle-induced-bremsstrahlung-doses
#16
Dusan Mrdja, Kristina Bikit, Istvan Bikit, Jaroslav Slivka, Sofija Forkapic, Jovana Knezevic
It is well known that the protection from external irradiation produced by beta emitters is simpler than the corresponding shielding of radioactive sources that emit gamma radiation. This is caused by relatively strong absorption (i.e. short range) of electrons in different materials. However, for strong beta sources specific attention should be devoted to the bremsstrahlung radiation induced in the source encapsulation (matrix), especially for emitters with relatively high beta-endpoint energy (1 MeV), that are frequently used in nuclear medicine...
October 11, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29019240/ph-dependent-assembly-of-porphyrin-silica-nanocomposites-and-their-application-in-targeted-photodynamic-therapy
#17
Jiefei Wang, Yong Zhong, Xiao Wang, Weitao Yang, Feng Bai, Bingbo Zhang, Leanne Alarid, Kaifu Bian, Hongyou Fan
Structurally controlled nanoparticles, such as core-shell nanocomposite particles by combining two or more compositions possess enhanced or new functionalities that benefited from synergistic coupling of the two components. Here we report new nanocomposite particles with self-assembled porphyrin arrays as the core surrounded by amorphous silica as the shell. Synthesis of such nanocomposite nanoparticles was conducted through a combined surfactant micelle confined self-assembly and silicate sol-gel process using optically active porphyrin as a functional building block...
October 11, 2017: Nano Letters
https://www.readbyqxmd.com/read/29019170/drug-delivery-from-an-innovative-lama-laba-co-suspension-delivery-technology-fixed-dose-combination-mdi-evidence-of-consistency-robustness-and-reliability
#18
Amber Doty, Jon Schroeder, Kou Vang, Mark Sommerville, Mervin Taylor, Brad Flynn, David Lechuga-Ballesteros, Peter Mack
To ensure consistency of clinical outcomes, orally inhaled therapies must exhibit consistent delivered dose and aerosol properties at the time of manufacturing, throughout storage, and during various patient-use conditions. Achieving consistency across these scenarios has presented a significant challenge, especially for combination products that contain more than one drug. This study characterized the delivered dose and aerosol properties of glycopyrrolate/formoterol fumarate metered dose inhaler (GFF MDI; Bevespi Aerosphere™)...
October 10, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29018443/extracellular-vesicles-arising-from-apoptotic-cells-in-tumors-roles-in-cancer-pathogenesis-and-potential-clinical-applications
#19
REVIEW
Catherine Lynch, Maria Panagopoulou, Christopher D Gregory
It is known that apoptotic cells can have diverse effects on the tumor microenvironment. Emerging evidence indicates that, despite its renowned role in tumor suppression, apoptosis may also promote oncogenic evolution or posttherapeutic relapse through multiple mechanisms. These include immunomodulatory, anti-inflammatory, and trophic environmental responses to apoptosis, which drive tumor progression. Our group has introduced the term "onco-regenerative niche (ORN)" to describe a conceptual network of conserved cell death-driven tissue repair and regeneration mechanisms that are hijacked in cancer...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29017974/vectofusin-1-a-potent-peptidic-enhancer-of-viral-gene-transfer-forms-ph-dependent-%C3%AE-helical-nanofibrils-concentrating-viral-particles
#20
Louic S Vermeer, Loic Hamon, Alicia Schirer, Michel Schoup, Jérémie Cosette, Saliha Majdoul, David Pastré, Daniel Stockholm, Nathalie Holic, Petra Hellwig, Anne Galy, David Fenard, Burkhard Bechinger
Gene transfer using lentiviral vectors has therapeutic applications spanning from monogenic and infectious diseases to cancer. Such gene therapy has to be improved by enhancing the levels of viral infection of target cells and/or reducing the amount of lentivirus for greater safety and reduced costs. Vectofusin-1, a recently developed cationic amphipathic peptide with a pronounced capacity to enhance such viral transduction, strongly promotes the entry of several retroviral pseudotypes into target cells when added to the culture medium...
October 7, 2017: Acta Biomaterialia
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