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https://www.readbyqxmd.com/read/29457518/surface-modification-of-doxorubicin-loaded-nanoparticles-based-on-polydopamine-with-ph-sensitive-property-for-tumor-targeting-therapy
#1
Dongdong Bi, Lei Zhao, Runqi Yu, Haowen Li, Yifei Guo, Xiangtao Wang, Meihua Han
One major challenge of current surface modification of nanoparticles is the demand for chemical reactive polymeric layers, such modification is always complicated, inefficient, and may lead the polymer lose the ability to encapsulate drug. To overcome this limitation, we adopted a pH-sensitive platform using polydopamine (PDA) as a way of functionalizing nanoparticles (NPs) surfaces. All this method needed to be just a brief incubation in weak alkaline solution of dopamine, which was simple and applicable to a variety of polymer carriers regardless of their chemical reactivity...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29457449/catalytically-active-single-chain-polymeric-nanoparticles-exploring-their-functions-in-complex-biological-media
#2
Yiliu Liu, Silvia Pujals, Patrick J M Stals, Thomas Pauloehrl, Stanislav I Presolski, E W Meijer, Lorenzo Albertazzi, Anja R A Palmans
Dynamic single-chain polymeric nanoparticles (SCPNs) are intriguing, bioinspired architectures that result from the collapse or folding of an individual polymer chain into a nanometer-sized particle. Here we present a detailed biophysical study on the behavior of dynamic SCPNs in living cells and an evaluation of their catalytic functionality in such a complex medium. We first developed a number of delivery strategies that allowed the selective localization of SCPNs in different cellular compartments. Live/dead tests showed that the SCPNs were not toxic to cells while spectral imaging revealed that SCPNs provide a structural shielding and reduced the influence from the outer biological media...
February 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29454929/hur-mediated-scn5a-mrna-stability-reduces-arrhythmic-risk-in-heart-failure
#3
Anyu Zhou, An Xie, Tae Yun Kim, Hong Liu, Guangbin Shi, Gyeoung-Jin Kang, Ning Jiang, Man Liu, Euy-Myoung Jeong, Bum-Rak Choi, Samuel C Dudley
BACKGROUND: Downregulated sodium currents in heart failure (HF) has been linked to increased arrhythmic risk. Reduced expression of mRNA stabilizing protein ELAVL1/HuR may be responsible for the downregulation of sodium channel gene SCN5A mRNA. OBJECTIVE: To investigate whether HuR regulates SCN5A mRNA expression and whether manipulation of HuR benefits arrhythmia control in HF. METHODS: Quantitative real-time reverse-transcriptase PCR (qRT-PCR) were used to investigate the expression of SCN5A...
February 15, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29453535/toxicity-of-metal-oxide-nanoparticles
#4
Koyeli Girigoswami
In the recent times, nanomaterials are used in many sectors of science, medicine and industry, without revealing its toxic effects. Thus, it is in urgent need for exploring the toxicity along with the application of such useful nanomaterials. Nanomaterials are categorized with a particle size of 1-100 nm. They have gained increasing attention because of their novel properties, including a large specific surface area and high reaction activity. The various fundamental and practical applications of nanomaterials include drug delivery, cell imaging, and cancer therapy...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29448602/preparation-of-silica-coated-magnetic-nanoparticles-for-bioseparation
#5
Dae-Won Lee, Hira Fatima, Kyo-Seon Kim
Magnetic nanoparticles have been intensively developed and applied in several biomedical applications such as targeted delivery, drug therapy, hyperthermia, magnetic resonance imaging and bioseparation etc. This work describes a simple and convenient method to synthesize silica coated Fe3O4 nanoparticles which have the potential to be used in the bioseparation of fetuin from fetal bovine serum and albumin from the egg. In this work, uniform Fe3O4 particles were prepared through the one-pot solvothermal process at 200 °C for 12 h using a sole iron precursor (FeCl3 · 6H2O) and then were coated with SiO2 to prepare silica coated Fe3O4 nanoparticles by hydrolysis and condensation of tetraethyl orthosilicate in ethanol and H2O medium...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448218/polymer-adhesion-predictions-for-oral-dosage-forms-to-enhance-drug-administration-safety-part-1-in-vitro-approach-using-particle-interaction-methods
#6
Nélio Drumond, Sven Stegemann
Solid oral dosage forms (SODF) are drug vehicles commonly prescribed by physicists in primary and secondary cares, as they are the most convenient for the patient and facilitate therapy management. Concerns regarding unintended adhesion of SODF during oro-esophageal transit remain, especially in multimorbid patients, bedridden patients and patients suffering from dysphagia. Hence, this factor should be considered during the development of SODF, and more attention should be given on the design of appropriate surface conditions considering patients with swallowing problems...
February 9, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29448116/immunoliposomes-in-clinical-oncology-state-of-the-art-and-future-perspectives
#7
REVIEW
María Merino, Sara Zalba, María J Garrido
Liposomal formulations entrapping a vast number of molecules have improved cancer therapies overcoming certain pharmacokinetic (PK) and pharmacodynamic limitations, many of which are associated with tumor characteristics. In this context, immunoliposomes represent a new strategy that has been widely investigated in preclinical cancer models with promising results, although few have reached the stage of clinical trials. This contrasts with the emerging clinical application of monoclonal antibodies (mAbs). This formulation allows the conjugation of different mAbs or antibody derivatives, such as monovalent variable fragments Fab', to the polymers covering the surface of liposomes...
February 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29445728/radiation-induced-cardiovascular-disease-mechanisms-and-importance-of-linear-energy-transfer
#8
REVIEW
Christopher B Sylvester, Jun-Ichi Abe, Zarana S Patel, K Jane Grande-Allen
Radiation therapy (RT) in the form of photons and protons is a well-established treatment for cancer. More recently, heavy charged particles have been used to treat radioresistant and high-risk cancers. Radiation treatment is known to cause cardiovascular disease (CVD) which can occur acutely during treatment or years afterward in the form of accelerated atherosclerosis. Radiation-induced cardiovascular disease (RICVD) can be a limiting factor in treatment as well as a cause of morbidity and mortality in successfully treated patients...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29442906/amine-functionalized-silica-nanoparticles-with-drug-and-gene-co-delivery-for-anti-angiogenesis-therapy-of-breast-cancer
#9
Xiaojin Gong, Qian Zhao, Mu Song, Feng Xue
In our study, we report on the design and characterization of a combined angiogenesis therapy for breast cancer based on well-formed amine-functionalized silica nanoparticles (SLNs). The aminefunctionalized SLNs was employed to simultaneously deliver angiostatin (ANG) plasmid and candesartan (CD) to the same cancer cell. The well-formed ANG/CD/SLNs exhibited small particle size, reasonable positive charges, excellent loading of drug and gene in vitro. Moreover, aminefunctionalized SLNs were almost no cytotoxicity...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442900/doxorubicin-loaded-silica-nanoparticles-with-dual-modification-as-a-tumor-targeted-drug-delivery-system-for-colon-cancer-therapy
#10
Yong-Quan Lin, Jing Zhang, Shi-Jiang Liu, Hui Ye
In the following study, we describe the preparation and characterization of poly(ethylene glycol) (PEG) and biotin modified, doxorubicin (DOX) loaded silica nanoparticles (Dox/SLN-PEG-Biotin), which was employed as a drug delivery system for colon cancer therapy. The DOX/SLN-PEG-Biotin exhibited small particle size and low cytotoxicity in vitro. Moreover, the Dox releases from DOX/SLN-PEG-Biotin followed a redox-sensitive behavior. Biotin functionalized Dox/SLN-PEG-Biotin demonstrated tumor-targeted delivery of their payload, resulting in enhanced cellular uptake in HCT116 tumor cells and potentiated tumor accumulation in HCT116 tumor-bearing mice...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442622/chitosan-stabilized-gold-folate-poly-lactide-co-glycolide-nanoplexes-facilitate-efficient-gene-delivery-in-hepatic-and-breast-cancer-cells
#11
Jude Akinyelu, Moganavelli Singh
The biodegradable polymer, poly(lactide-co-glycolide) is a popular polymer of choice in many nanotherapeutic studies. Herein, we report on the synthesis and evaluation of four chitosan stabilized poly(lactide-co-glycolide) nanoparticles with and without coating with gold, and the targeting ligand, folic acid, as potential non-viral gene delivery vectors. The poly(lactide-co-glycolide) nanoparticles were synthesized via nanoprecipitation/solvent evaporation method in conjunction with the surface functionalizing folic acid and chitosan...
July 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442050/inhibiting-the-proliferation-migration-and-invasion-of-triple-negative-breast-cancer-cells-through-anti-tumor-human-serum-albumin-nanoparticles-loading-aziditaxel-as-a-novel-taxane-derivative
#12
Li-Qing Chen, Zhe-Ming Zhang, Wei Huang, Zhong-Gao Gao, Wei-Shuo Fang, Ming-Ji Jin, Lian Yu
Triple negative breast cancer (TNBC) is a severe breast cancer subtype with the high mortality rate, and still is lack of effective therapeutic means so far. Aziditaxel, a water-insoluble compound, is a novel taxane derivative with strong anti-tumor activity. In this study, we constructed an aziditaxel-loaded nano drug delivery system using human serum albumin as a carrier, and further investigated its anti-tumor effect on TNBC in vitro. An emulsion solvent evaporation method was employed to prepare aziditaxel-loaded human serum albumin nanoparticles (AT-NPs)...
March 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441958/preparation-and-in-vivo-evaluation-of-cytochrome-c-containing-liposomes
#13
O G Katsai, O A Ruban, Y M Krasnopolskyi
This study investigates the development of a method for obtaining cytochrome C-containing liposomes (LS-Cyt), and evaluates their stability and specific activity. LS-Cyt were intended for the therapy of ophthalmic diseases. LS-Cyt were prepared by high pressure homogenization technique and lyophilized to obtain freeze-dried LS-Cyt. It was proposed to use anionic phospholipid- dipalmitoylphosphatidylglycerol (DPPG-Na) and phosphatidylcholine (PC) in a nanoparticulate composition. Were investigated various concentrations of lactose and trehalose as cryoprotectants...
December 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29440896/intranasal-delivery-of-huperzine-a-to-the-brain-using-lactoferrin-conjugated-n-trimethylated-chitosan-surface-modified-plga-nanoparticles-for-treatment-of-alzheimer-s-disease
#14
Qingqing Meng, Aiping Wang, Hongchen Hua, Ying Jiang, Yiyun Wang, Hongjie Mu, Zimei Wu, Kaoxiang Sun
Background: Safe and effective delivery of therapeutic drugs to the brain is important for successful therapy of Alzheimer's disease (AD). Purpose: To develop Huperzine A (HupA)-loaded, mucoadhesive and targeted polylactide-co-glycoside (PLGA) nanoparticles (NPs) with surface modification by lactoferrin (Lf)-conjugated N-trimethylated chitosan (TMC) (HupA Lf-TMC NPs) for efficient intranasal delivery of HupA to the brain for AD treatment. Methods: HupA Lf-TMC NPs were prepared using the emulsion-solvent evaporation method and optimized using the Box-Behnken design...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29440875/experimental-and-molecular-modeling-approach-to-optimize-suitable-polymers-for-fabrication-of-stable-fluticasone-nanoparticles-with-enhanced-dissolution-and-antimicrobial-activity
#15
Shaimaa Ahmed, Thirumala Govender, Inamullah Khan, Nisar Ur Rehman, Waqar Ali, Syed Muhammad Hassan Shah, Shahzeb Khan, Zahid Hussain, Riaz Ullah, Mansour S Alsaid
Background and aim: The challenges with current antimicrobial drug therapy and resistance remain a significant global health threat. Nanodrug delivery systems are playing a crucial role in overcoming these challenges and open new avenues for effective antimicrobial therapy. While fluticasone (FLU), a poorly water-soluble corticosteroid, has been reported to have potential antimicrobial activity, approaches to optimize its dissolution profile and antimicrobial activity are lacking in the literature...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29440626/upper-bound-dose-values-for-meson-radiation-in-heavy-ion-therapy
#16
Carolina Rabin, Marcello Gomes Gonçalves, Sergio Barbosa Duarte, Gabriel Gonzalez Sprinberg
Radiation treatments of cancer have evolved to include massive particle beams, instead of traditional irradiation procedures. Thus patient doses and workers radiological protection became issues of constant concern for these new technologies, especially for proton- and heavy-ion-therapy. In beam energies of interest of heavy-ion-therapy, secondary particle radiation comes from proton, neutron and neutral and charged pions produced in the nuclear collisions of the beam with human tissue atoms. This work, for the first time, offers the upper bound of meson radiation dose in organic tissues due to secondary meson radiation in heavy-ion therapy...
February 14, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29439305/strategic-application-of-radiotherapy-for-hepatocellular-carcinoma
#17
Seo Hee Choi, Jinsil Seong
With increasing clinical use, radiotherapy (RT) has been considered reliable and effective method for hepatocellular carcinoma (HCC) treatment, depending on extent of disease and patient characteristics. RT for HCC can improve therapeutic outcomes through excellent local control, downstaging, conversion from unresectable to resectable status, and treatments of unresectable HCCs with vessel invasion or multiple intrahepatic metastases. In addition, further development of modern RT technologies, including image-guided radiotherapy (IGRT), intensity-modulated radiotherapy (IMRT), and stereotactic body radiotherapy, has expanded the indication of RT...
February 14, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29436756/alirocumab-versus-usual-lipid-lowering-care-as-add-on-to-statin-therapy-in-individuals-with-type-2-diabetes-and-mixed-dyslipidaemia-the-odyssey-dm-dyslipidemia-randomized-trial
#18
Kausik K Ray, Lawrence A Leiter, Dirk Müller-Wieland, Bertrand Cariou, Helen M Colhoun, Robert R Henry, Francisco J Tinahones, Maja Bujas-Bobanovic, Catherine Domenger, Alexia Letierce, Rita Samuel, Stefano Del Prato
AIMS: Individuals with type 2 diabetes (T2DM) and mixed dyslipidaemia represent a high-risk and difficult-to-treat population. ODYSSEY DM-DYSLIPIDEMIA (NCT02642159) compared alirocumab, a proprotein convertase subtilisin-kexin type 9 inhibitor, with usual care (UC) in individuals with T2DM and mixed dyslipidaemia not optimally managed by maximally-tolerated statins. MATERIALS AND METHODS: UC options (no additional lipid-lowering therapy; fenofibrate; ezetimibe; omega-3 fatty acid; nicotinic acid) were selected prior to stratified randomization to open-label alirocumab 75 mg every 2 weeks (Q2W; with increase to 150 mg Q2W at Week [W]12 if W8 non-high-density lipoprotein cholesterol [non-HDL-C] was ≥2...
February 13, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29435410/comparison-of-a-new-nanoform-of-the-photosensitizer-chlorin-e6-based-on-plant-phospholipids-with-its-free-form
#19
Lyubov V Kostryukova, Vladimir N Prozorovskiy, Natalya V Medvedeva, Olga M Ipatova
Photodynamic therapy is an advanced method of treating cancer and various benign diseases, including infections. It uses light-activated molecules [photosensitizers (PSs)] to generate reactive oxygen species (ROS) when irradiated with light of a specific wavelength. This study examined the photophysical and photosensitizing activity of the PS chlorin e6 incorporated in a delivery system based on plant phospholipids. This new nanoform of chlorin e6 comprised particles with a diameter of 18.4 ± 2.5 nm and zeta potential of -34...
February 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29433876/autogenous-hepatic-tissue-transplantation-into-the-omentum-in-a-novel-ectopic-liver-regeneration-murine-model
#20
Francisco Igor Macedo, Joseph J Eid, Milessa Decker, Barry Herschman, Edsa Negussie, Vijay K Mittal
BACKGROUND: Liver regeneration involves hyperplasia and hypertrophy of hepatic cells. The capacity of macroscopic liver tissue to regenerate in ectopic sites is unknown. We aim to develop a novel in vivo model of ectopic liver survivability and regeneration and assess its functionality. METHODS: Adult male Sprague-Dawley rats (n = 23) were divided into four groups: (1) single-stage (SS) group, wedge liver resection was performed, and the parenchyma was directly implanted into the omentum; (2) double-stage (DS) group, omentum pedicle was transposed over the left hepatic lobe followed by wedge liver resection along with omental flap; (3) Biogel + DS group, rats received intraperitoneal injection of inert polymer particles prior to DS; (4) Biogel + DS + portal vein ligation (PVL) group, Biogel + DS rats underwent subsequent PVL...
March 2018: Journal of Surgical Research
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