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Carbon ion radiotherapy

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https://www.readbyqxmd.com/read/28212708/development-and-performance-evaluation-of-a-three-dimensional-clinostat-synchronized-heavy-ion-irradiation-system
#1
Hiroko Ikeda, Hikaru Souda, Anggraeini Puspitasari, Kathryn D Held, Jun Hidema, Takeshi Nikawa, Yukari Yoshida, Tatsuaki Kanai, Akihisa Takahashi
Outer space is an environment characterized by microgravity and space radiation, including high-energy charged particles. Astronauts are constantly exposed to both microgravity and radiation during long-term stays in space. However, many aspects of the biological effects of combined microgravity and space radiation remain unclear. We developed a new three-dimensional (3D) clinostat synchronized heavy-ion irradiation system for use in ground-based studies of the combined exposures. Our new system uses a particle accelerator and a respiratory gating system from heavy-ion radiotherapy to irradiate samples being rotated in the 3D clinostat with carbon-ion beams only when the samples are in the horizontal position...
February 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/28190704/high-risk-prostate-cancer-and-radiotherapy-the-past-and-the-future-a-benchmark-for-a-new-mixed-beam-radiotherapy-approach
#2
Giulia Marvaso, Barbara A Jereczek-Fossa, Giulia Riva, Camilla Bassi, Cristiana Fodor, Delia Ciardo, Raffaella Cambria, Floriana Pansini, Dario Zerini, Paolo De Marco, Federica Cattani, Ottavio De Cobelli, Roberto Orecchia
BACKGROUND: The prognosis for patients with high-risk prostate cancer is poor. No consensus exists on the most effective treatment. The aim of this retrospective study was to identify the biochemical progression-free survival and the toxicity profile of patients with localized high-risk prostate cancer treated with external beam radiation therapy. These results will constitute a benchmark for a prospective "mixed beam" trial: a boost with carbon ions followed by a pelvic photon intensity-modulated radiotherapy (NCT02672449 [clinicaltrials...
January 18, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28181819/dose-escalation-study-with-respiratory-gated-carbon-ion-scanning-radiotherapy-using-a-simultaneous-integrated-boost-for-pancreatic-cancer-simulation-with-four-dimensional-computed-tomography
#3
Shohei Kawashiro, Shinichiro Mori, Shigeru Yamada, Kentaro Miki, Kenji Nemoto, Hiroshi Tsuji, Tadashi Kamada
OBJECTIVES: Pancreatic cancer is a difficult-to-treat disease with a persistently high mortality rate. We evaluated dose distribution simulation with respiratory-gated carbon-ion pencil beam scanning (C-PBS) with a simultaneous integrated boost (SIB) to increase tumor dose, sparing organs at risk (OARs). METHODS: Using four-dimensional computed tomography (4DCT) data of 12 patients, we delineated gross tumor volume (GTV) and two clinical target volumes (CTVs). To consider beam range intrafractional uncertainty, we calculated field-specific target volumes (FTVs), from which two planning target volumes (PTVs) were generated...
February 9, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28152251/diffusion-weighted-mri-treatment-monitoring-of-primary-hypofractionated-proton-and-carbon-ion-prostate-cancer-irradiation-using-raster-scan-technique
#4
Maya B Wolf, Christopher Edler, Diana Tichy, Matthias C Röthke, Heinz-Peter Schlemmer, Klaus Herfarth, David Bonekamp
PURPOSE: To investigate parametric changes in the apparent diffusion coefficient (ADC) at multiple timepoints during and after completion of primary proton and carbon ion irradiation of prostate cancer (PCa) as compared with normal-appearing prostate parenchyma. MATERIALS AND METHODS: In all, 92 patients with histologically confirmed PCa received either proton or carbon ion hypofractionated radiotherapy (RT). All were prospectively evaluated with diffusion-weighted magnetic resonance imaging (DWI-MRI) at five timepoints: baseline, day 10 during therapy and 6 weeks, 6 months, and 18 months after treatment...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28133196/-a-case-of-remnant-pancreatic-cancer-after-pancreatoduodenectomy-successfully-treated-using-chemotherapy-and-carbon-ion-radiotherapy
#5
Tatsuhito Yamamoto, Kazuhisa Tokunou, Hisato Yamamoto, Ryoji Kamei, Yoshinori Kitamura, Seiichirou Ando
We report a case of remnant pancreatic cancer after pancreatoduodenectomy that was successfully treated using chemotherapy and carbon-ion radiotherapy. A 68-year-old woman received SSPPD for pancreatic head cancer. Gemcitabine(GEM) was administered for a year as postoperative chemotherapy. One year 8 months after surgery, abdominal CT showed a 20 mm solid mass in the stump of the remnant pancreas and dilation of the distal pancreatic duct. FDG-PET revealed a solitary tumor without any recurrence. We diagnosed the patient with a solitary recurrence of pancreatic cancer...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133027/-an-85-year-old-man-with-lymph-node-metastasis-of-recurrent-rectal-cancer-treated-usingproton-beam-therapy
#6
Kohei Murata, Tomohiro Kitahara, Yoichiro Nushijima, Shu Okamura, Takayuki Minoji, Rie Hamano, Nariaki Fukuchi, Chikara Ebisui, Tetsu Yanagisawa, Hideoki Yokouchi, Masakatsu Kinuta, Yusuke Demizu, Tomoaki Okimoto
There are few reports that describe the efficacy of proton beam therapy for lymph node metastasis of recurrent rectal cancer, and carbon ion radiotherapy yields higher local tumor control rates. Proton beam therapy needs a longer treatment period but is less toxic to adjacent healthy organs compared to carbon ion radiotherapy. Here we report an 85-year-old man who underwent curative surgery for rectal and sigmoid cancer at the age of 76 years. After 4 years and 2 months, he had liver metastases at S3 and S8, both of which were resected...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28114112/secondary-radiation-measurements-for-particle-therapy-applications-prompt-photons-produced-by-4-he-12-c-and-16-o-ion-beams-in-a-pmma-target
#7
I Mattei, F Bini, F Collamati, E De Lucia, P M Frallicciardi, E Iarocci, C Mancini-Terracciano, M Marafini, S Muraro, R Paramatti, V Patera, L Piersanti, D Pinci, A Rucinski, A Russomando, A Sarti, A Sciubba, E Solfaroli Camillocci, M Toppi, G Traini, C Voena, G Battistoni
Charged particle beams are used in particle therapy (PT) to treat oncological patients due to their selective dose deposition in tissues with respect to the photons and electrons used in conventional radiotherapy. Heavy (Z  >  1) PT beams can additionally be exploited for their high biological effectiveness in killing cancer cells. Nowadays, protons and carbon ions are used in PT clinical routines. Recently, interest in the potential application of helium and oxygen beams has been growing. With respect to protons, such beams are characterized by their reduced multiple scattering inside the body, increased linear energy transfer, relative biological effectiveness and oxygen enhancement ratio...
February 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28091564/mitotic-catastrophe-is-a-putative-mechanism-underlying-the-weak-correlation-between-sensitivity-to-carbon-ions-and-cisplatin
#8
Daijiro Kobayashi, Takahiro Oike, Atsushi Shibata, Atsuko Niimi, Yoshiki Kubota, Makoto Sakai, Napapat Amornwhichet, Yuya Yoshimoto, Yoshihiko Hagiwara, Yuka Kimura, Yuka Hirota, Hiro Sato, Mayu Isono, Yukari Yoshida, Takashi Kohno, Tatsuya Ohno, Takashi Nakano
In cancer therapy today, carbon ion radiotherapy is used mainly as monotherapy, whereas cisplatin is used concomitantly with X-ray radiotherapy. The effectiveness of concomitant carbon ions and cisplatin is unclear. To obtain the information on the mechanisms potentially shared between carbon ions or X-rays and cisplatin, we assessed the correlation of sensitivity to the single treatments. In 20 human cancer cell lines, sensitivity to X-rays strongly correlated with sensitivity to cisplatin, indicating the presence of potentially shared target mechanisms...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28081010/biological-dose-representation-for-carbon-ion-radiotherapy-of-unconventional-fractionation
#9
Nobuyuki Kanematsu, Taku Inaniwa
In carbon-ion radiotherapy, single-beam delivery each day in alternate directions has been common practice for efficient operation, taking advantage of the Bragg peak and the relative biological effectiveness (RBE) for uniform dose conformation to a tumor. Treatments are usually fractionated and treatment plans are evaluated with the total RBE-weighted dose; however, this is of limited relevance to the biological effect. In this study, we reformulate the biologically effective dose (BED) to normalize the dose-fractionation and cell-repopulation effects as well as the RBE of treating radiation, based on inactivation of a reference cell line by a reference carbon-ion radiation...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28070729/inhibiting-autophagy-with-chloroquine-enhances-the-anti-tumor-effect-of-high-let-carbon-ions-via-er-stress-related-apoptosis
#10
Xiaogang Zheng, Xiaodong Jin, Feifei Li, Xiongxiong Liu, Yan Liu, Fei Ye, Ping Li, Ting Zhao, Qiang Li
Energetic carbon ions (CI) offer great advantages over conventional radiations such as X- or γ-rays in cancer radiotherapy. High linear energy transfer (LET) CI can induce both endoplasmic reticulum (ER) stress and autophagy in tumor cells under certain circumstances. The molecular connection between ER stress and autophagy in tumor exposed to high-LET radiation and how these two pathways influence the therapeutic effect against tumor remain poorly understood. In this work, we studied the impact of autophagy and apoptosis induced by ER stress following high-LET CI radiation on the radiosensitivity of S180 cells both in vitro and in vivo...
February 2017: Medical Oncology
https://www.readbyqxmd.com/read/28062703/tas-116-a-novel-hsp90-inhibitor-selectively-enhances-radiosensitivity-of-human-cancer-cells-to-x-rays-and-carbon-ion-radiation
#11
Younghyun Lee, Shigeaki Sunada, Hirokazu Hirakawa, Akira Fujimori, Jac A Nickoloff, Ryuichi Okayasu
Hsp90 inhibitors have been investigated as cancer therapeutics in monotherapy and to augment radiotherapy; however, serious adverse effects of early-generation Hsp90 inhibitors limited their development. TAS-116 is a novel Hsp90 inhibitor with lower adverse effects than other Hsp90 inhibitors, and here, we investigated the radiosensitizing effects of TAS-116 in low linear energy transfer (LET) X-ray and high LET carbon ion-irradiated human cancer cells and mouse tumor xenografts. TAS-116 decreased cell survival of both X-ray and carbon ion-irradiated human cancer cell lines (HeLa and H1299 cells), and similar to other Hsp90 inhibitors, it did not affect radiosensitivity of noncancerous human fibroblasts...
January 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28057427/fiducial-marker-matching-versus-vertebral-body-matching-dosimetric-impact-of-patient-positioning-in-carbon-ion-radiotherapy-for-primary-hepatic-cancer
#12
Satoshi Abe, Yoshiki Kubota, Kei Shibuya, Yoshinori Koyama, Takanori Abe, Tatsuya Ohno, Takashi Nakano
PURPOSE: The aim of this study was to compare the dose-volume parameters of fiducial marker matching (MM) with vertebral body matching (VM) in patient positioning for carbon ion radiotherapy for primary hepatic cancer. MATERIALS AND METHODS: Twenty patients with primary hepatic cancer were retrospectively studied to assess changes in reproducibility of tumor position and dose distribution on two CT scans. One was for treatment planning and another was for dose confirmation, acquired the day before the first treatment day...
January 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28048697/su-f-t-199-a-new-strategy-for-integrating-photon-with-proton-and-carbon-ion-in-the-treatment-planning
#13
Z Chen, J Wang, W Hu
PURPOSE: The aim of this study was to develop a viable strategy to integrate photon plan and proton/carbon ion plan based on deformable registration. METHODS: Two prostate cancer patients were enrolled in this study. Each patient has 2 CTs, which were input in the Raystation radiotherapy treatment planning system (TPS). CT1 was deformed to the second CT2 using the Hybrid deformation method. The dice similarity coefficient (DSC) parameter was used to evaluate the difference between the actual structures (bladder, rectum and CTV) and the corresponding deformed structures on CT2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047357/su-f-t-190-homogeneity-study-of-proton-and-heavy-ion-scanning-beams-based-on-different-compositions-of-spot-sizes-fwhm-and-grid-sizes
#14
J Zhao, W Hu, Y Xing, X Wu, Y Li
PURPOSE: Different particle scanning beam delivery systems have different delivery accuracies. This study was performed to determine, for our particle treatment system, an appropriate composition (n=FWHM/GS) of spot size(FWHM) and grid size (GS), which can provide homogenous delivered dose distributions for both proton and heavy ion scanning beam radiotherapy. METHODS: We analyzed the delivery errors of our beam delivery system using log files from the treatment of 28 patients...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047315/su-f-t-124-radiation-biological-equivalent-presentations-oflem-1-and-mkm-approaches-in-the-carbon-ion-radiotherapy
#15
W Hsi, G Jiang, Y Sheng
PURPOSE: To study the correlations of the radiation biological equivalent doses (BED) along depth and lateral distance between LEM-1 and MKM approaches. METHODS: In NIRS-MKM (Microdosimetric Kinetic Model) approach, the prescribed BED, referred as C-Eq, doses aims to present the relative biological effectiveness (RBE) for different energies of carbon-ions on a fixed 10% survival value of HCG cell with respect to convention X-ray. Instead of a fixed 10% survival, the BED doses of LEM-1 (Local Effect Model) approach, referred as X-Eq, aims to present the RBE over the whole survival curve of chordoma-like cell with alpha/beta ratio of 2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047192/su-c-204-04-irradiation-of-human-cell-lines-using-various-ions
#16
Y Lin, C Tessa, A Rusek, S McMahon, T Kaminuma, K Held
PURPOSE: The purpose of this study is to investigate and quantify the biological effects of ion radiation using several human cell lines. We aim to answer the question of whether carbon ion the most ideal ion species for heavy ion radiotherapy. METHODS: The cells were irradiated at different positions along the pristine Bragg peak of several ions with different atomic number. The biological effectiveness was evaluated using the clonogenic cell survival assay. Irradiation of three human lung cancer cell lines and a fibroblast cell line were undertaken using the charged particle beam at the NASA Space Radiation Laboratory at Brookhaven National Lab...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043947/five-year-quality-of-life-assessment-after-carbon-ion-radiotherapy-for-prostate-cancer
#17
Katsuya Maruyama, Hiroshi Tsuji, Takuma Nomiya, Hiroyuki Katoh, Hitoshi Ishikawa, Tadashi Kamada, Masaru Wakatsuki, Koichiro Akakura, Jun Shimazaki, Hidefumi Aoyama, Hirohiko Tsujii
The aim of this study was to prospectively assess 5-year health-related quality of life (HRQOL) of patients treated with carbon ion radiotherapy (C-ion RT) for clinically localized prostate cancer. A total of 417 patients received carbon ion radiotherapy at a total dose of 63-66 Gray-equivalents (GyE) in 20 fractions over 5 weeks, and neoadjuvant and adjuvant androgen deprivation therapy (ADT) were administered for intermediate and high-risk patients. A HRQOL assessment was performed at five time points (immediately before the initiation of C-ion RT, immediately after, and at 12, 36 and 60 months after completion of C-ion RT) using Functional Assessment of Cancer Therapy (FACT) questionnaires...
January 1, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28028129/long-term-outcomes-after-carbon-ion-radiotherapy-for-oral-mucosal-malignant-melanoma
#18
Kensuke Naganawa, Masashi Koto, Ryo Takagi, Azusa Hasegawa, Hiroaki Ikawa, Kazuo Shimozato, Tadashi Kamada, Yoshitaka Okamoto
Oral mucosal malignant melanoma (OMM) is extremely rare and has a poor prognosis. Owing to its rarity, it has not yet been possible to establish an optimal treatment modality. The objective of this study was to evaluate the long-term efficacy of carbon-ion radiotherapy (C-ion RT) for OMM. Between 1997 and 2013, 19 patients with OMM were treated with C-ion RT alone. Patient ages ranged from 44 to 84 years (median, 69 years). Nine men and 10 women were included. OMMs were restaged in accordance with the seventh edition of the tumour/node/metastasis (TNM) Staging System of the International Union Against Cancer...
December 26, 2016: Journal of Radiation Research
https://www.readbyqxmd.com/read/28009421/phase-ii-multi-institutional-clinical-trial-on-a-new-mixed-beam-rt-scheme-of-imrt-on-pelvis-combined-with-a-carbon-ion-boost-for-high-risk-prostate-cancer-patients
#19
Giulia Marvaso, Barbara A Jereczek-Fossa, Barbara Vischioni, Delia Ciardo, Tommaso Giandini, Azusa Hasegawa, Federica Cattani, Mauro Carrara, Mario Ciocca, Nice Bedini, Sergio Villa, Sara Morlino, Stefania Russo, Dario Zerini, Sarah Pia Colangione, Costanza Maria Vittoria Panaino, Cristiana Fodor, Luigi Santoro, Emanuele Pignoli, Francesca Valvo, Riccardo Valdagni, Ottavio De Cobelli, Roberto Orecchia
PURPOSE: Definition of the optimal treatment schedule for high-risk prostate cancer is under debate. A combination of photon intensity modulated radiotherapy (IMRT) on pelvis with a carbon ion boost might be the optimal treatment scheme to escalate the dose on prostate and deliver curative dose with respect to normal tissue and quality of dose distributions. In fact, carbon ion beams offer the advantage to deliver hypofractionated radiotherapy (RT) using a significantly smaller number of fractions compared to conventional RT without increasing risks of late effects...
December 2, 2016: Tumori
https://www.readbyqxmd.com/read/28007628/a-dose-escalation-clinical-trial-of-single-fraction-carbon-ion-radiotherapy-for-peripheral-stage-i-non-small-cell-lung-cancer
#20
Naoyoshi Yamamoto, Tadaaki Miyamoto, Mio Nakajima, Masataka Karube, Kazuhiko Hayashi, Hiroshi Tsuji, Hirohiko Tsujii, Tadashi Kamada, Takehiko Fujisawa
PURPOSE: To report initial results ofadose escalation trial of single-fraction carbon-ion radiotherapy (CIRT) for peripheralstage I non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: Between April, 2003 and February, 2012, 218 patients were treated. The total dose was raised from 28to 50Gy RBE. The patients were 157 males and 61 females with a median age of 75 years. The tumors were 123 T1 and 95 T2. One hundred thirty-four of these patients (61.5%) were medically inoperable...
December 19, 2016: Journal of Thoracic Oncology
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