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Carbon ion radiotherapy

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https://www.readbyqxmd.com/read/28730646/prospective-observational-study-of-carbon-ion-radiotherapy-for-non-squamous-cell-carcinoma-of-the-head-and-neck
#1
Katsuyuki Shirai, Jun-Ichi Saitoh, Atsushi Musha, Takanori Abe, Daijiro Kobayashi, Takeo Takahashi, Tomoaki Tamaki, Hidemasa Kawamura, Yukihiro Takayasu, Masato Shino, Minoru Toyoda, Katsumasa Takahashi, Junko Hirato, Satoshi Yokoo, Kazuaki Chikamatsu, Tatsuya Ohno, Takashi Nakano
To evaluate the efficacy and safety of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck. Thirty-five patients were enrolled in this prospective study. The primary endpoint was the 3-year local control rate, while secondary endpoints included the 3-year overall survival rate and adverse events. Acute and late adverse events were evaluated according to the Common Terminology Criteria for Adverse Events, version 4.0. The median follow-up time for all patients was 39 months. Thirty-two and 3 patients received 64...
July 21, 2017: Cancer Science
https://www.readbyqxmd.com/read/28727901/carbon-ion-radiotherapy-for-isolated-para-aortic-lymph-node-recurrence-from-colorectal-cancer
#2
Yuka Isozaki, Shigeru Yamada, Shohei Kawashiro, Shigeo Yasuda, Naomi Okada, Daniel Ebner, Hiroshi Tsuji, Tadashi Kamada, Hisahiro Matsubara
BACKGROUND: The safety and effectiveness of carbon-ion radiotherapy (CIRT) for isolated para-aortic lymph node (PALN) metastasis was evaluated retrospectively. METHODS: CIRT for isolated PALN metastasis from CRC was performed in 34 cases from June 2006 to August 2015 in our institute. A median dose of 52.8 Gy(RBE) (range, 48-52.8 Gy(RBE)) was delivered with a median daily dose of 4.4 Gy(RBE) (range, 4.0-4.4 Gy(RBE)). RESULTS: The median follow-up duration for all patients was 24...
July 20, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28662297/progressive-hypofractionated-carbon-ion-radiotherapy-for-hepatocellular-carcinoma-combined-analyses-of-2-prospective-trials
#3
Goro Kasuya, Hirotoshi Kato, Shigeo Yasuda, Hiroshi Tsuji, Shigeru Yamada, Yasuo Haruyama, Gen Kobashi, Daniel K Ebner, Naomi Nagatake Okada, Hirokazu Makishima, Masaru Miyazaki, Tadashi Kamada, Hirohiko Tsujii
BACKGROUND: The objective of this study was to evaluate the safety and efficacy of carbon-ion radiotherapy (CIRT) in patients with hepatocellular carcinoma (HCC) with stepwise dose escalation and hypofractionation in 2 combined prospective trials. METHODS: Sequential phase 1/2 (protocol 9603) and phase 2 (protocol 0004) trials were conducted for patients with histologically proven HCC. The phase 1 component of protocol 9603 was a dose-escalation study; CIRT was delivered in 12, 8, or 4 fractions...
June 29, 2017: Cancer
https://www.readbyqxmd.com/read/28644151/ecg-based-4d-dose-reconstruction-of-cardiac-arrhythmia-ablation-with-carbon-ion-beams-application-in-a-porcine-model
#4
Daniel Richter, H Immo Lehmann, Anna Eichhorn, Anna M Constantinescu, Robert Kaderka, Matthias Prall, Patrick Lugenbiel, Mitsuru Takami, Dierk Thomas, Christoph Bert, Marco Durante, Douglas L Packer, Christian Graeff
Noninvasive ablation of cardiac arrhythmia by scanned particle radiotherapy is highly promising, but especially challenging due to cardiac and respiratory motion. Irradiations for catheter-free ablation in intact pigs were carried out at the GSI Helmholtz Center in Darmstadt using scanned carbon ions. Here, we present real-time electrocardiogram (ECG) data to estimate time-resolved (4D) delivered dose. For 11 animals, surface ECGs and temporal structure of beam delivery were acquired during irradiation. R waves were automatically detected from surface ECGs...
June 23, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28638385/intercellular-communication-of-tumor-cells-and-immune-cells-after-exposure-to-different-ionizing-radiation-qualities
#5
REVIEW
Sebastian Diegeler, Christine E Hellweg
Ionizing radiation can affect the immune system in many ways. Depending on the situation, the whole body or parts of the body can be acutely or chronically exposed to different radiation qualities. In tumor radiotherapy, a fractionated exposure of the tumor (and surrounding tissues) is applied to kill the tumor cells. Currently, mostly photons, and also electrons, neutrons, protons, and heavier particles such as carbon ions, are used in radiotherapy. Tumor elimination can be supported by an effective immune response...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28624428/undifferentiated-sarcoma-of-the-sphenoid-sinus
#6
Masaya Nagaishi, Kensuke Suzuki, Yoshiki Sugiura, Issei Takano, Yoshihiro Tanaka, Akio Hyodo
Paranasal sinuses sarcomas are rare and no treatments have been established. We report a young-adult case of sphenoid sinus sarcoma treated by carbon-ion radiotherapy. The patient presented with progressive left-sided visual impairment. A tumor was then identified and partial resection by transnasal approach was performed. The resected mass showed typical morphology of mesenchymal tumor, and morphological and molecular analyses ruled out a predominant-differentiation phenotype. The pathological diagnosis was undifferentiated sarcoma...
June 14, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28598362/carbon-ion-radiotherapy-a-review-of-clinical-experiences-and-preclinical-research-with-an-emphasis-on-dna-damage-repair
#7
REVIEW
Osama Mohamad, Brock J Sishc, Janapriya Saha, Arnold Pompos, Asal Rahimi, Michael D Story, Anthony J Davis, D W Nathan Kim
Compared to conventional photon-based external beam radiation (PhXRT), carbon ion radiotherapy (CIRT) has superior dose distribution, higher linear energy transfer (LET), and a higher relative biological effectiveness (RBE). This enhanced RBE is driven by a unique DNA damage signature characterized by clustered lesions that overwhelm the DNA repair capacity of malignant cells. These physical and radiobiological characteristics imbue heavy ions with potent tumoricidal capacity, while having the potential for simultaneously maximally sparing normal tissues...
June 9, 2017: Cancers
https://www.readbyqxmd.com/read/28595643/planning-strategies-for-inter-fractional-robustness-in-pancreatic-patients-treated-with-scanned-carbon-therapy
#8
Vania Batista, Daniel Richter, Stephanie E Combs, Oliver Jäkel
BACKGROUND: Managing inter-fractional anatomy changes is a challenging task in radiotherapy of pancreatic tumors, especially in scanned carbon-ion delivery. This treatment planning study aims to focus on clinically feasible solutions, such as the beam angle selection and margin design to increase the robustness against inter-fractional uncertainties. METHODS: This study included 10 patients with weekly 3D-CT imaging and physician-approved Clinical Target Volume (CTV)...
June 8, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28590042/changes-in-arrhythmogenic-properties-and-five-year-prognosis-after-carbon-ion-radiotherapy-in-patients-with-mediastinum-cancer
#9
Mari Amino, Koichiro Yoshioka, Makiyoshi Shima, Tohru Okada, Mio Nakajima, Yoshiya Furusawa, Shigetaka Kanda, Sadaki Inokuchi, Teruhisa Tanabe, Yuji Ikari, Tadashi Kamada
INTRODUCTION: Carbon-ion irradiation of rabbit hearts has improved left ventricular conduction abnormalities through upregulation of gap junctions. However, to date, there has been no investigation on the effect of carbon-ion irradiation on electrophysiological properties in human. We investigated this effect in patients with mediastinum extra-cardiac cancer treated with carbon-ion radiotherapy that included irradiating the heart. METHODS AND RESULTS: In April-December 2009, eight patients were prospectively enrolled (including two male, aged 72...
June 7, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28588712/maximum-standardized-uptake-value-on-fdg-pet-predicts-survival-in-stage-i-non-small-cell-lung-cancer-following-carbon-ion-radiotherapy
#10
Katsuyuki Shirai, Takanori Abe, Jun-Ichi Saitoh, Tatsuji Mizukami, Daisuke Irie, Yosuke Takakusagi, Shintaro Shiba, Naoko Okano, Takeshi Ebara, Tatsuya Ohno, Takashi Nakano
The present study (University Hospital Medical Information Network study no. UMIN000003797) aimed to evaluate whether the maximum standardized uptake value (SUVmax) of pretreatment (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) is prognostic factor for stage I non-small cell lung cancer (NSCLC) treated with carbon ion radiotherapy (C-ion RT). Patients treated between June 2010 and June 2013 at Gunma University Heavy Ion Medical Center (Maebashi, Japan) on a prospective protocol were included in the present study...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28576582/visualization-of-air-and-metal-inhomogeneities-in-phantoms-irradiated-by-carbon-ion-beams-using-prompt-secondary-ions
#11
T Gaa, M Reinhart, B Hartmann, J Jakubek, P Soukup, O Jäkel, M Martišíková
PURPOSE: Non-invasive methods for monitoring of the therapeutic ion beam extension in the patient are desired in order to handle deteriorations of the dose distribution related to changes of the patient geometry. In carbon ion radiotherapy, secondary light ions represent one of potential sources of information about the dose distribution in the irradiated target. The capability to detect range-changing inhomogeneities inside of an otherwise homogeneous phantom, based on single track measurements, is addressed in this paper...
May 30, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28566628/histone-deacetylase-inhibitors-sensitize-murine-b16f10-melanoma-cells-to-carbon-ion-irradiation-by-inducing-g1-phase-arrest
#12
Katsuyo Saito, Tomoo Funayama, Yuichiro Yokota, Takashi Murakami, Yasuhiko Kobayashi
Epigenetic processes, in addition to genetic abnormalities, play a critical role in refractory malignant diseases and cause the unresponsiveness to various chemotherapeutic regimens and radiotherapy. Herein we demonstrate that histone deacetylase inhibitors (HDACis) can be used to sensitize malignant melanoma B16F10 cells to carbon ion irradiation. The cells were first treated with HDACis (romidepsin [FK228, depsipeptide], trichostatin A [TSA], valproic acid [VPA], and suberanilohydroxamic acid [SAHA, vorinostat]) and were then exposed to two types of radiation (carbon ions and gamma-rays)...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28558766/prognostic-analysis-of-radiation-pneumonitis-carbon-ion-radiotherapy-in-patients-with-locally-advanced-lung-cancer
#13
Kazuhiko Hayashi, Naoyoshi Yamamoto, Masataka Karube, Mio Nakajima, Naruhiro Matsufuji, Hiroshi Tsuji, Kazuhiko Ogawa, Tadashi Kamada
BACKGROUND: Carbon-ion radiotherapy (CIRT) is a promising treatment for locally advanced non-small-cell lung cancer, especially for patients with inoperable lung cancer. Although the incidence of CIRT-induced radiation pneumonitis (RP) ≥ grade 2 ranges from 2.5 to 9.9%, the association between CIRT-induced RP and dosimetric parameters is not clear. Herein, we identified prognostic factors associated with symptomatic RP after CIRT for patients with non-small-cell lung cancer. METHODS: Clinical results of 65 patients treated with CIRT between 2000 and 2015 at the National Institute of Radiological Sciences were retrospectively analyzed...
May 30, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28528680/prognostic-factors-of-adenoid-cystic-carcinoma-of-the-head-and-neck-in-carbon-ion-radiotherapy-the-impact-of-histological-subtypes
#14
Hiroaki Ikawa, Masashi Koto, Ryo Takagi, Daniel K Ebner, Azusa Hasegawa, Kensuke Naganawa, Toshinao Takenouchi, Toshitaka Nagao, Takeshi Nomura, Takahiko Shibahara, Hiroshi Tsuji, Tadashi Kamada
PURPOSE: The aim of this study was to evaluate the effect of histological subtypes of head and neck adenoid cystic carcinoma (ACC) on the results of carbon-ion radiotherapy (CIRT). MATERIAL AND METHODS: Of the 113 patients with ACC who were treated with CIRT between December 2006 and July 2013, 100 patients with identified histological subtypes were enrolled in this study. CIRT at a total dose of 57.6 or 64.0Gy (RBE) was administered in 16 fractions. Histological grading was defined as the presence or absence of a solid growth pattern...
May 18, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28500630/e2f-is-involved-in-radioresistance-of-carbon-ion-induced-apoptosis-via-bax-caspase-3-signal-pathway-in-human-hepatoma-cell
#15
Xie Yi, S I Jing, Wang Yu-Pei, L I Hong-Yan, D I Cui-Xia, Yan Jun-Fang, Y E Yan-Cheng, Zhang Yan-Shan, Zhang Hong
Deletion of p53, most common genetic alteration, is observed in human tumors and reported to lead to improve in cell radioresistance. Heavy-ion irradiation (IR) could induce p53-/- cancer cells apoptosis. However, little is known regarding the molecular mechanism in this type of cell apoptosis. The present studies have focused on mechanisms state of signaling pathways as an activator of the cell fate decisions induced by heavy ion IR without p53. Carbon ion IR could induce up-regulation of E2F1 expression in cancer cells...
May 13, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28482173/evaluation-of-a-combination-tumor-treatment-using-thermo-triggered-liposomal-drug-delivery-and-carbon-ion-irradiation
#16
Daisuke Kokuryo, Ichio Aoki, Eiji Yuba, Kenji Kono, Sadahito Aoshima, Jeff Kershaw, Tsuneo Saga
The combination of radiotherapy with chemotherapy is one of the most promising strategies for cancer treatment. Here, a novel combination strategy utilizing carbon ion irradiation as a high-linear energy transfer (LET) radiotherapy and a thermo-triggered nanodevice is proposed, and drug accumulation in the tumor and treatment effects are evaluated using magnetic resonance imaging relaxometry and immunohistology (Ki-67, n = 15). The thermo-triggered liposomal anticancer nanodevice was administered into colon-26 tumor-grafted mice, and drug accumulation and efficacy was compared for 6 groups (n = 32) that received or did not receive the radiotherapy and thermo trigger...
April 21, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28474791/multi-institutional-retrospective-study-of-mucoepidermoid-carcinoma-treated-with-carbon-ion-radiotherapy
#17
Katsuyuki Shirai, Masashi Koto, Yusuke Demizu, Hiroaki Suefuji, Tatsuya Ohno, Hiroshi Tsuji, Tomoaki Okimoto, Yoshiyuki Shioyama, Jun-Ichi Saitoh, Kenji Nemoto, Takashi Nakano, Tadashi Kamada
This study aimed to evaluate the clinical outcomes of patients with mucoepidermoid carcinomas in the head and neck treated with carbon-ion radiotherapy. Data from 26 patients who underwent carbon-ion radiotherapy in four facilities were analyzed in this multi-institutional retrospective study: the Japan Carbon-ion Radiation Oncology Study Group. The median follow-up time was 34 months. One patient experienced local recurrence, and the 3-year local control rate was 95%. One patient developed lymph node recurrence and five developed distant metastases...
July 2017: Cancer Science
https://www.readbyqxmd.com/read/28468632/erratum-to-carbon-ion-radiotherapy-for-desmoid-tumor-of-the-abdominal-wall-a-case-report
#18
Takuya Nagata, Yusuke Demizu, Tomoyuki Okumura, Shinichi Sekine, Naoki Hashimoto, Nobukazu Fuwa, Tomoaki Okimoto, Yutaka Shimada
No abstract text is available yet for this article.
May 3, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28399182/clinical-outcomes-using-carbon-ion-radiotherapy-and-dose-volume-histogram-comparison-between-carbon-ion-radiotherapy-and-photon-therapy-for-t2b-4n0m0-non-small-cell-lung-cancer-a-pilot-study
#19
Katsuyuki Shirai, Motohiro Kawashima, Jun-Ichi Saitoh, Takanori Abe, Kyohei Fukata, Yuka Shigeta, Daisuke Irie, Shintaro Shiba, Naoko Okano, Tatsuya Ohno, Takashi Nakano
The safety and efficacy of carbon-ion radiotherapy for advanced non-small cell lung cancer have not been established. We evaluated the clinical outcomes and dose-volume histogram parameters of carbon-ion radiotherapy compared with photon therapy in T2b-4N0M0 non-small cell lung cancer. Twenty-three patients were treated with carbon-ion radiotherapy between May 2011 and December 2015. Seven, 14, and 2 patients had T2b, T3, and T4, respectively. The median age was 78 (range, 53-91) years, with 22 male patients...
2017: PloS One
https://www.readbyqxmd.com/read/28368853/three-dimensional-reconstruction-of-therapeutic-carbon-ion-beams-in-phantoms-using-single-secondary-ion-tracks
#20
Anna Merle Reinhart, Claudia Katharina Spindeldreier, Jan Jakubek, Mária Martišíková
Carbon ion beam radiotherapy enables a very localised dose deposition. However, even small changes in the patient geometry or positioning errors can significantly distort the dose distribution. A live, non-invasive monitoring system of the beam delivery within the patient is therefore highly desirable, and could improve patient treatment. We present a novel three-dimensional method for imaging the beam in the irradiated object, exploiting the measured tracks of single secondary ions emerging under irradiation...
April 3, 2017: Physics in Medicine and Biology
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